CN105233223A - Blood sugar reducing dissolved medicine and preparation method thereof - Google Patents
Blood sugar reducing dissolved medicine and preparation method thereof Download PDFInfo
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- CN105233223A CN105233223A CN201510752284.4A CN201510752284A CN105233223A CN 105233223 A CN105233223 A CN 105233223A CN 201510752284 A CN201510752284 A CN 201510752284A CN 105233223 A CN105233223 A CN 105233223A
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Abstract
The invention discloses blood sugar reducing dissolved medicine and a preparation method thereof. The blood sugar reducing dissolved medicine is prepared from, by weight, 10-20 parts of milkvetch roots, 10-15 parts of pericarpium citri reticulatae, 10-12 parts of corn stigma, 8-10 parts of lotus leaves, 3-5 parts of cape jasmine, 1-5 parts of white hyacinth beans, 1-2 parts of fresh ginger and 3-5 parts of liquorice through the steps of extracting, filtering, concentration and drying. The blood sugar reducing dissolved medicine is reasonable in component and high in synergistic interaction function, and the prepared blood sugar reducing dissolved medicine is remarkable in blood sugar reducing function, has obvious relieving effects on polydipsia, dieresis, polyphagia, emaciation, lassitude and other symptoms caused by diabetes, and can be independently taken to maintain daily blood sugar or used with the assistance of blood sugar reducing western medicine.
Description
Technical field
The invention belongs to Medicines and Health Product technical field, be specifically related to a kind of blood sugar lowering electuary and preparation method thereof.
Background technology
Diabetes be one group caused by body defect of insulin secretion and/or insulin action obstacle, take hyperglycemia as the metabolic disease of principal character.Persistent high blood sugar and long-term metabolic disorder etc. can cause body tissue's organ, particularly to eye, kidney, cardiovascular and neural infringement and dysfunction thereof and exhaustion, severe patient can cause dehydration, the acute complications such as electrolyte disturbance and acid base imbalance, ketoacidosis and Hyperosmotic coma.In addition, no matter be type Ⅰ diabetes mellitus or type Ⅱdiabetes mellitus, all need long-term treatment, bring huge misery and heavy financial burden to patient and family members thereof.
China is one of diabetes country occurred frequently, has diabetics about 100,000,000, therefore how to reduce blood glucose, controls and one of problem that the various symptoms that diabetes-alleviating causes are modern people to be paid close attention to the most.Much prevent, treat diabetes or fall hypoglycemic medicines and health protection product although existing on market, great majority are chemicals or insulin type hormone, all have untoward reaction in various degree, and little with the compound antihypelipidemic product of pure natural medical compatibility.
Summary of the invention
The object of the present invention is to provide a kind of blood sugar lowering electuary and preparation method thereof, gained electuary blood sugar reducing function is remarkable, and the polydipsia, polyuria, the polyphagia that cause diabetes, to become thin and the symptom such as fatigue and weak all has obvious mitigation.
For achieving the above object, the present invention adopts following technical scheme:
A kind of blood sugar lowering electuary, its medicinal raw material used is counted by weight: Radix Astragali 10-20 part, Pericarpium Citri Reticulatae 10-15 part, Stigma Maydis 10-12 part, Folium Nelumbinis 8-10 part, Fructus Gardeniae 3-5 part, Semen Lablab Album 1-5 part, Rhizoma Zingiberis Recens 1-2 part, Radix Glycyrrhizae 3-5 part.
The preparation method of described blood sugar lowering electuary comprises the steps:
1), after the Radix Astragali, Pericarpium Citri Reticulatae, Folium Nelumbinis, Radix Glycyrrhizae being pulverized, decoct with water 50 ~ 80min by mass volume ratio 1:2 ~ 3, after cooling, collect cooking liquor, obtain extracting solution A;
2) Stigma Maydis is decocted with water 40 ~ 60min by mass volume ratio 1:1 ~ 2, after cooling, collect cooking liquor, obtain extracting solution B;
3) in Fructus Gardeniae, add water infiltration 1-1.5h by mass volume ratio 1:1.2 ~ 1.6, then the Fructus Gardeniae of infiltration is pulled out, add by mass volume ratio 1:1-2 the alcoholic solution that mass concentration is 70 ~ 90%, supersound extraction 20-40min, collect ethanol extract; Then in residue, decoct with water 40 ~ 60min by mass volume ratio 1:2-3, after cooling, collect cooking liquor, gained cooking liquor and ethanol extract are merged, obtains extracting solution C;
4) mash after being cleaned by fresh ginger, strand gets its juice, obtains Rhizoma Zingiberis Recens juice;
4) extracting solution A, B, C are mixed with Rhizoma Zingiberis Recens juice, through ultrafiltration, concentrate to obtain medical material dope;
5) in medical material dope, add the dextrin of its weight 2-5%, after stirring, spraying dry 30 ~ 40min at 90-95 DEG C, 60-80 mesh sieve crossed by gained powder, to obtain final product.
The Radix Astragali is warm in nature, sweet in the mouth; Return lung, spleen channel; Have the effect such as invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis weak for the deficiency of vital energy, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, blood deficiency dull yellowish colored skin, interior-heat such as to be quenched one's thirst the disease.Modern study shows, the Radix Astragali by increasing glycogen synthase activity, IRS activity, protein kinase B and protein kinase C activity, thus playing increase body insulin sensitivity, falling hypoglycemic effect.
Pericarpium Citri Reticulatae bitter in the mouth, pungent, warm in nature, return lung, spleen channel; Be the Chinese medicine of traditional regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, there is the multiple efficacies such as antioxidation, antiinflammatory, antitumor, blood fat reducing.Show, with Pericarpium Citri Reticulatae feeding hyperglycemia model mice, to there is extremely remarkable hypoglycemic effect after deliberation.
Stigma Maydis sweet in the mouth, property is put down, and has effect of calming liver and clearing heat, diuresis damp eliminating, can be used for disease such as treatment hypertension, diabetes etc.The effect can played and reduce blood fat, blood pressure and blood glucose is taken by boil water for Stigma Maydis.
Folium Nelumbinis is put down, bitter in the mouth, puckery; GUIXIN, liver, spleen, gallbladder, lung meridian; There is the effect such as clearing away summer-heat, sending up the lucid YANG, dissipating blood stasis hemostasis, for diseases such as heat-damp in summer excessive thirst, dizzy, the splenasthenic abdominal distentions of having a headache.Modern study shows, the flavone aglycone in Folium Nelumbinis has good hypoglycemic activity, and can improve diabetic complication.
Fructus Gardeniae is cold in nature, the micro-acid of taste, hardship, GUIXIN, lung, tri-jiao channel; Have effect of pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis and removing pathogenic heat from blood and toxic substance from the body, modern pharmacology research shows, jasminoidin contained in Fructus Gardeniae has the effects such as hepatic cholagogic, anti-inflammatory and antalgic, antioxidation, blood pressure lowering, blood sugar lowering, antitumor.
Semen Lablab Album slightly warm in nature, sweet in the mouth; Return spleen, stomach warp; Have invigorating the spleen for eliminating dampness and in the effect such as to relieve summer heat, for diseases such as weakness of the spleen and stomach, inappetence, diarrhea, heat-damp in summer vomiting and diarrhoea, abdominal distention uncomfortable in chest.Modern study shows, long-term edible Semen Lablab Album is conducive to insulin normal secretions, has significant preventive and therapeutic effect to type Ⅱdiabetes mellitus complicated hypertension disease.
Rhizoma Zingiberis Recens acrid in the mouth, slightly warm in nature, return lung, spleen channel; It not only has effect of Tumor suppression, appetite promoting and the spleen strengthening, preventing heatstroke, disinfecting detoxifying, modern medicine study also proves, piquancy component 6-gingerol contained in Rhizoma Zingiberis Recens can promote that adipose cell increases, thus the dextrose components in absorbing blood, play the effect reducing blood glucose value.
Radix Glycyrrhizae property is put down, and taste is put down; GUIXIN, lung, spleen, stomach warp; There are the effects such as invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for diseases such as weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, and can cushion toxicity, strong.Modern study shows, Radix Glycyrrhizae contains the material that some have anti-diabetic effect, and these materials not only can reduce blood glucose, can also antiinflammatory, and toleration is fabulous.
remarkable advantage of the present invention is: the present invention uses tradition and modern Chinese medicine theory, utilize the medicinal raw material of multiple medicine-food two-purpose, the compound granules with good blood sugar reducing function is developed through scientific composition, its reasonable recipe, synergistic function are strong, and its polydipsia that diabetes are caused, polyuria, polyphagia, to become thin and the symptom such as fatigue and weak all has obvious mitigation, can take separately the maintenance for daily blood glucose, or assistant hypoglycemic Western medicine uses.
Detailed description of the invention
More being convenient to make content of the present invention understand, below in conjunction with detailed description of the invention, technical solutions according to the invention are described further, but the present invention being not limited only to this.
Embodiment 1
A kind of blood sugar lowering electuary, its medicinal raw material used is counted by weight: the Radix Astragali 10 parts, Pericarpium Citri Reticulatae 10 parts, Stigma Maydis 10 parts, 8 parts, Folium Nelumbinis, Fructus Gardeniae 3 parts, Semen Lablab Album 1 part, 1 part, Rhizoma Zingiberis Recens, 3 parts, Radix Glycyrrhizae.
Its preparation method comprises the steps:
1), after the Radix Astragali, Pericarpium Citri Reticulatae, Folium Nelumbinis, Radix Glycyrrhizae being pulverized, decoct with water 80min by mass volume ratio 1:2, after cooling, collect cooking liquor, obtain extracting solution A;
2) Stigma Maydis is decocted with water 60min by mass volume ratio 1:1, after cooling, collect cooking liquor, obtain extracting solution B;
3) in Fructus Gardeniae, add water infiltration 1.5h by mass volume ratio 1:1.2, then the Fructus Gardeniae of infiltration is pulled out, add by mass volume ratio 1:2 the alcoholic solution that mass concentration is 70%, supersound extraction 40min, collect ethanol extract; Then in residue, decoct with water 60min by mass volume ratio 1:2, after cooling, collect cooking liquor, gained cooking liquor and ethanol extract are merged, obtains extracting solution C;
4) mash after being cleaned by fresh ginger, strand gets its juice, obtains Rhizoma Zingiberis Recens juice;
4) extracting solution A, B, C are mixed with Rhizoma Zingiberis Recens juice, through ultrafiltration, concentrate to obtain medical material dope;
5) in medical material dope, add the dextrin of its weight 2%, after stirring, spraying dry 40min at 90 DEG C, 60 mesh sieves crossed by gained powder, to obtain final product.
Embodiment 2
A kind of blood sugar lowering electuary, its medicinal raw material used is counted by weight: the Radix Astragali 14 parts, Pericarpium Citri Reticulatae 12 parts, Stigma Maydis 11 parts, 9 parts, Folium Nelumbinis, Fructus Gardeniae 4 parts, Semen Lablab Album 2 parts, 1 part, Rhizoma Zingiberis Recens, 4 parts, Radix Glycyrrhizae.
Its preparation method comprises the steps:
1), after the Radix Astragali, Pericarpium Citri Reticulatae, Folium Nelumbinis, Radix Glycyrrhizae being pulverized, decoct with water 70min by mass volume ratio 1:2, after cooling, collect cooking liquor, obtain extracting solution A;
2) Stigma Maydis is decocted with water 50min by mass volume ratio 1:2, after cooling, collect cooking liquor, obtain extracting solution B;
3) in Fructus Gardeniae, add water infiltration 1.2h by mass volume ratio 1:1.4, then the Fructus Gardeniae of infiltration is pulled out, add by mass volume ratio 1:1.5 the alcoholic solution that mass concentration is 80%, supersound extraction 30min, collect ethanol extract; Then in residue, decoct with water 50min by mass volume ratio 1:2, after cooling, collect cooking liquor, gained cooking liquor and ethanol extract are merged, obtains extracting solution C;
4) mash after being cleaned by fresh ginger, strand gets its juice, obtains Rhizoma Zingiberis Recens juice;
4) extracting solution A, B, C are mixed with Rhizoma Zingiberis Recens juice, through ultrafiltration, concentrate to obtain medical material dope;
5) in medical material dope, add the dextrin of its weight 3%, after stirring, spraying dry 35min at 92 DEG C, 60 mesh sieves crossed by gained powder, to obtain final product.
Embodiment 3
A kind of blood sugar lowering electuary, its medicinal raw material used is counted by weight: the Radix Astragali 20 parts, Pericarpium Citri Reticulatae 15 parts, Stigma Maydis 12 parts, 10 parts, Folium Nelumbinis, Fructus Gardeniae 5 parts, Semen Lablab Album 5 parts, 2 parts, Rhizoma Zingiberis Recens, 5 parts, Radix Glycyrrhizae.
Its preparation method comprises the steps:
1), after the Radix Astragali, Pericarpium Citri Reticulatae, Folium Nelumbinis, Radix Glycyrrhizae being pulverized, decoct with water 50min by mass volume ratio 1:3, after cooling, collect cooking liquor, obtain extracting solution A;
2) Stigma Maydis is decocted with water 40min by mass volume ratio 1:2, after cooling, collect cooking liquor, obtain extracting solution B;
3) in Fructus Gardeniae, add water infiltration 1h by mass volume ratio 1:1.6, then the Fructus Gardeniae of infiltration is pulled out, add by mass volume ratio 1:1 the alcoholic solution that mass concentration is 90%, supersound extraction 20min, collect ethanol extract; Then in residue, decoct with water 40min by mass volume ratio 1:3, after cooling, collect cooking liquor, gained cooking liquor and ethanol extract are merged, obtains extracting solution C;
4) mash after being cleaned by fresh ginger, strand gets its juice, obtains Rhizoma Zingiberis Recens juice;
4) extracting solution A, B, C are mixed with Rhizoma Zingiberis Recens juice, through ultrafiltration, concentrate to obtain medical material dope;
5) in medical material dope, add the dextrin of its weight 5%, after stirring, spraying dry 30min at 95 DEG C, 80 mesh sieves crossed by gained powder, to obtain final product.
model case
Example 1: patient, female, 52 years old, suffers from more than 10 years of diabetes.Often blood glucose can be controlled with the medicine such as glyburide, metformin.Glycemic control is undesirable in recent years, and blood glucose is everlasting between 9 ~ 11mmol/L and is fluctuated, and with symptoms such as polydipsia, polyuria, polyphagia and fatigue and weaks, uses the medicines such as hydrochloric acid pioglitazone, acarbose instead, be aided with hypoglycemic instant powder of the present invention and carry out auxiliary treatment.After serveing on 15 days, the symptoms such as polydipsia, polyphagia, polyuria are alleviated to some extent, and feeling of fatigue alleviates, and check glucostasis is at 6.2-7.0mmol/L.Take after 2 months and attempt withdrawing blood sugar lowering Western medicine, only take hypoglycemic instant powder of the present invention, and take diet and exercise therapy, check the ideal range of glycemic control at about 6mmol/L after 1 month, simultaneously the symptom such as polydipsia, polyphagia, polyuria disappears completely.
Example 2: patient, man, 46 years old, because of thirsty polydipsia, through hospital diagnosis, it suffered from type 2 diabetes mellitus.Patient is reluctant to take Western medicine antidiabetic drug, selects to take hypoglycemic instant powder of the present invention, after serveing on 3 days, thirsty polydipsia symptom is obviously alleviated, for consolidate curative effect continues to take for 5 week, and check blood glucose per week 1 time, all belong in normal range, the ill front level of weight recovery after 1 month.
Example 3: patient, man, 75 years old, suffers from more than 20 years of diabetes.Often control blood glucose with medicines such as glyburide, metformin, acarbose, glycemic control is undesirable in recent years, is everlasting between 8 ~ 10mmol/L to fluctuate, conscious thirsty, hyperhidrosis, frequent urination at night and fatigue and weak, is aided with hypoglycemic instant powder of the present invention and treats.After serveing on 7 days, the symptoms such as polydipsia, polyphagia, polyuria are alleviated to some extent, feeling of fatigue alleviates, and checks glucostasis at 7.0-8.0mmol/L, after continuing to take 20 days, the symptoms such as polydipsia, polyphagia, polyuria obviously disappear, take after 2 months and attempt withdrawing blood sugar lowering Western medicine, only take hypoglycemic instant powder of the present invention, and take diet and exercise therapy, take after 2 months and check the ideal range of glycemic control at about 6mmol/L, simultaneously the symptom such as polydipsia, polyphagia, polyuria disappears completely.
The foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (3)
1. a blood sugar lowering electuary, is characterized in that: medicinal raw material used is counted by weight: Radix Astragali 10-20 part, Pericarpium Citri Reticulatae 10-15 part, Stigma Maydis 10-12 part, Folium Nelumbinis 8-10 part, Fructus Gardeniae 3-5 part, Semen Lablab Album 1-5 part, Rhizoma Zingiberis Recens 1-2 part, Radix Glycyrrhizae 3-5 part.
2. a preparation method for blood sugar lowering electuary as claimed in claim 1, is characterized in that: it comprises the steps:
1), after the Radix Astragali, Pericarpium Citri Reticulatae, Folium Nelumbinis, Radix Glycyrrhizae being pulverized, decoct with water 50 ~ 80min by mass volume ratio 1:2 ~ 3, after cooling, collect cooking liquor, obtain extracting solution A;
2) Stigma Maydis is decocted with water 40 ~ 60min by mass volume ratio 1:1 ~ 2, after cooling, collect cooking liquor, obtain extracting solution B;
3) in Fructus Gardeniae, add water infiltration 1-1.5h by mass volume ratio 1:1.2 ~ 1.6, then the Fructus Gardeniae of infiltration is pulled out, add by mass volume ratio 1:1-2 the alcoholic solution that mass concentration is 70 ~ 90%, supersound extraction 20-40min, collect ethanol extract; Then in residue, decoct with water 40 ~ 60min by mass volume ratio 1:2-3, after cooling, collect cooking liquor, gained cooking liquor and ethanol extract are merged, obtains extracting solution C;
4) mash after being cleaned by fresh ginger, strand gets its juice, obtains Rhizoma Zingiberis Recens juice;
4) extracting solution A, B, C are mixed with Rhizoma Zingiberis Recens juice, through ultrafiltration, concentrate to obtain medical material dope;
5) in medical material dope, add the dextrin of its weight 2-5%, carry out spraying dry after stirring, 60-80 mesh sieve crossed by gained powder, to obtain final product.
3. the preparation method of blood sugar lowering electuary according to claim 2, it is characterized in that: spray-dired temperature described in step 5) is 90-95 DEG C, drying time is 30 ~ 40min.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107811185A (en) * | 2017-11-01 | 2018-03-20 | 西安天生物技术股份有限公司 | A kind of raw material of corn stigma beverage and preparation method thereof |
| CN114145374A (en) * | 2021-12-08 | 2022-03-08 | 山西振东五和医养堂股份有限公司 | Astragalus membranaceus and corn stigma composite tea and preparation method and application thereof |
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| CN103768407A (en) * | 2014-01-25 | 2014-05-07 | 福建省农业科学院农业生态研究所 | Compound blood glucose reducing capsules and preparation method thereof |
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| CN1237433A (en) * | 1998-06-03 | 1999-12-08 | 杨学忠 | Chinese medicine prescription and its preparation method |
| CN103768407A (en) * | 2014-01-25 | 2014-05-07 | 福建省农业科学院农业生态研究所 | Compound blood glucose reducing capsules and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107811185A (en) * | 2017-11-01 | 2018-03-20 | 西安天生物技术股份有限公司 | A kind of raw material of corn stigma beverage and preparation method thereof |
| CN114145374A (en) * | 2021-12-08 | 2022-03-08 | 山西振东五和医养堂股份有限公司 | Astragalus membranaceus and corn stigma composite tea and preparation method and application thereof |
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