CN1237433A - Chinese medicine prescription and its preparation method - Google Patents

Abstract

The present invention discloses a Chinese medicine prescription and its preparation process. Said invention uses corn silk and astragalus root as main raw material, and adopts a scientific preparation process to obtain the invented oral liquor and injection. It possesses the functions of inducing diuresis, purging away heat, reducing blood pressure, strengthening the kidney, calming the liver and normalizing functioning of the gall bladder, and can be used for curing the diseases of hypertension, edema, nephritis, icterohepatitis, cholecystitis, apostaxis and diabetes, etc..

Description

A kind of Chinese medicine preparation and processing technology thereof

The present invention relates to a kind of Chinese medicine preparation and processing technology thereof.

Diuretic life-time service such as the hydrochlorothiazide that existing market is sold, spironolactone disturb the uric acid secretion, suppress side effect such as beta Cell of islet function, and patients such as cirrhotic ascites, gout history, diabetes, yellow pox, allergic dermatitis are had the shortcoming that should not obey; That depressor such as clonidine have been taken is drowsiness, xerostomia, constipation, weak, bradycardia, dizziness, feel sick, side effect such as inappetence.

The objective of the invention is to utilize a kind of Chinese medicine preparation to be mixed with oral liquid and injection, body is had the effect that diuresis expels the heat-evil, kidney, suppressing the hyperactive liver function of gallbladder promoting are good in blood pressure lowering by the processing method of science.

Extract oral formula of liquid of the present invention is made up of Stigma Maydis, the Radix Astragali, vitamin c, potassium sorbate, sweeting agent, citric acid.

The processing technology of Chinese medicine oral liquid of the present invention is: (1) gets Stigma Maydis 600 grams, adds under the ultrafiltration water room temperature and soaks 30 minutes, decocts 2 times, decoct 1.2 hour after 14 times of ultrafiltration water boil each the adding, merge 2 times filtrate, supernatant is got in centrifugalize, filters by the 0.2um defecator, concentrating under reduced pressure becomes flowing soaking paste, add 3 times of methanol, left standstill behind the mix homogeneously 24 hours, leave and take the insoluble part of methanol, cold preservation is standby, separates and recovery methanol; (2) get the Radix Astragali 200 grams, section adds ultrafiltration water soak at room temperature 60 minutes, decocts 3 times, the difference lixiviate was 1.5 hours, 1.2 hours, 1 hour after 14 times of ultrafiltration water of each adding boiled, and merged 3 times filtrate, added an amount of potassium sorbate, citric acid, supernatant is got in centrifugalize, and cold preservation is standby; (3) get Stigma Maydis system liquid and Radix Astragali decocting liquid mix homogeneously, add vitamin c 5000mg, add an amount of sweeting agent, through 0.5um just filter, the sub-very much interception ultrafiltration of 0.2um fine straining, 6.7 gets pure clear liquid, adds spice, concentrating under reduced pressure is to 1000ml, 100 ℃, sterilization in 30 minutes promptly gets Chinese medicine oral liquid.

Chinese medicine oral liquid of the present invention is yellow clear liquid, and it is fragrant and sweet to distinguish the flavor of, and little have a corn abnormal smells from the patient; PH is between 6-6.5, and proportion is 1.1-1.2, functional component content: astragaloside 20-40mg/l, effect polysaccharide 1800-2000mg/l; Usage and dosage: oral, every day 2 times, each 20ml.

Oral liquid of the present invention has that diuresis expels the heat-evil, the effect of suppressing the hyperactive liver function of gallbladder promoting, strong kidney spleen reinforcing, blood sugar lowering, hemostasis, defying age, enhancing immunity, is used for the treatment of diseases such as hypertension, nephritis, hepatitis, yellow pox type hepatitis, cholecystitis, edema, diabetes, epistaxis, mastalgia.

Chinese medicine injection formula of liquid of the present invention is made up of Stigma Maydis, the Radix Astragali, vitamin c, benzyl alcohol.

The processing technology of Chinese medicine injection of the present invention is: (1) gets Stigma Maydis 5000g, adds ultrafiltration water and soaks at normal temperatures 30 minutes, high-temp extracting 2 times, add 14 times of ultrafiltration water, the back of boiling decocted 1 hour, merged 2 times filtrate at every turn, supernatant is collected in centrifugalize, successively by 0.5um, 0.2um defecator, concentrating under reduced pressure becomes flowing soaking paste then, adds 4 times of methanol, left standstill behind the mix homogeneously 24 hours, Separation and Recovery methanol is left and taken the insoluble part of methanol, and cold preservation is standby; (2) get Radix Astragali 500g, section adds ultrafiltration water soak at room temperature 60 minutes, and high-temp extracting 3 times adds 12 times of ultrafiltration water at every turn, and the back difference lixiviate 1.5 hours, 1.2 hours, 1 hour of boiling merges 3 times filtrate, and factor is the centrifugal supernatant of collecting more than 1.2 ten thousand; (3) the insoluble extractum of cold preservation Stigma Maydis methanol is fully mixed in Radix Astragali centrifuged supernatant, stay in the 6.7 ten thousand molecular weight ultrafiltration apparatus in the Tibetan and to filter, the filtration later stage ejects contained effective component with distilled water, gets pure clear liquid, and concentrating under reduced pressure is to 1000g, add 2 times of amount 90% ethanol, the cold preservation precipitation was filtered in 24 hours, and filtrate concentrating reclaimed ethanol, and concentrated solution adds 2 times of amount 90% ethanol again, precipitate filtration in 24 hours, filtrate concentrates and reclaims ethanol, to there not being alcohol fully, adds the 10ml benzyl alcohol, and add distilled water to full dose, adjusting pH value is 7.5, adds the 6000mg vitamin c, and fine straining is to 1000ml, 100 ℃, sterilization in 30 minutes promptly gets Chinese medicine injection.

Chinese medicine injection of the present invention is conspicuous color clear liquid, and pH value is 7.5, more than the effective component content astragaloside 0.1mg/ml, more than the effect polysaccharide 10mg/ml; Usage and dosage: intramuscular injection, a 2-4ml, every day 2 times; Each 10-20ml that infuses, every day 1 time.

Injection of the present invention has diuresis, blood pressure lowering, suppressing the hyperactive liver, function of gallbladder promoting, strong kidney, and the effect of enhancing human body immunity power is used for the treatment of diseases such as hypertension, edema, nephritis, yellow pox type hepatitis, hepatitis, cholecystitis.

Radix Astragali benefiting QI for strengthening the superficies, inducing diuresis to remove edema, poison holding, granulation promoting; The Stigma Maydis diuresis, expel the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting.Show that according to modern pharmacology the Radix Astragali has diuresis, protection myocardial ischemia, antagonism B _aCl ₂The rat ventricular that brings out, blood pressure regulation, blood sugar lowering, enhancing human body immunity, anti-aging effects; Stigma Maydis has diuresis, blood pressure lowering, blood sugar lowering, function of gallbladder promoting anastalsis, the two has promoting diuresis to eliminate damp pathogen, blood pressure lowering from Chinese medicine to the modern pharmacology, regulate renal function, the synergism of blood sugar lowering, the invigorating the spleen and replenishing QI of the Radix Astragali, invigorating the spleen and regulating the stomach have remedied the long-term medical deficiency of body fluid that is caused by promoting diuresis to eliminate damp pathogen of Stigma Maydis, Stigma Maydis expels the heat-evil, the profit of suppressing the hyperactive liver, function of gallbladder promoting is oozed and corrected Radix Astragali overabundance of YANG leading to deficiency of YIN person and avoid, and how angry patient is, and the disharmony in liver-QI person is the taboo of usefulness not.This prescription is main in order to oozing, ooze and not empty, mend and only, make the circulation of body body fluid unimpeded, reach equilibrium between yin and yang, the two collaborative and complementation make this product have no side effect to human body, and diseases such as treatment hypertension, edema, nephritis, jaundice type hepatitis, cholecystitis, edema, diabetes, epistaxis, mastalgia are reached significant curative effect.

Claims (4)

1, a kind of extract oral formula of liquid is characterized in that: be made up of Stigma Maydis, the Radix Astragali, vitamin c, potassium sorbate, sweeting agent, citric acid.

2, a kind of extract oral formula of liquid according to claim 1, the processing technology that it is characterized in that this oral liquid is: (1) is got Stigma Maydis and is added ultrafiltration water and soaked at normal temperatures 30 minutes, decoct 2 times, each 1.2 hours, merge 2 times filtrate, supernatant liquid filtering is collected in centrifugalize, concentrating under reduced pressure becomes flowing soaking paste, adds 3 times of methanol, leaves standstill behind the mix homogeneously 24 hours, leave and take the insoluble part of methanol, cold preservation is standby; (2) get the Radix Astragali and add ultrafiltration water soak at room temperature 60 minutes, decoct 3 times, each lixiviate 1.5 hours, 1.2 hours, 1 hour merges 3 times filtrate, adds an amount of potassium sorbate, citric acid, and supernatant is got in centrifugalize, and cold preservation is standby; (3) get Stigma Maydis system liquid and Radix Astragali medicinal liquid mix homogeneously and add appropriate vitamin c, sweeting agent through filter just, fine straining, ultrafiltration, gets pure clear liquid, adds spice, and concentrating under reduced pressure is to 1000m1, and 100 ℃, sterilization in 30 minutes promptly gets Chinese medicine oral liquid.

3, a kind of Chinese medicine injection formula of liquid is characterized in that: be made up of Stigma Maydis, the Radix Astragali, vitamin c, benzyl alcohol.

4, a kind of Chinese medicine injection formula of liquid according to claim 3, the processing technology that it is characterized in that this injection is: (1) is got Stigma Maydis and is added ultrafiltration water soak at room temperature 30 minutes, high-temp extracting 2 times, and the back of boiling decocted 1 hour, merge 2 times filtrate, supernatant liquid filtering is collected in centrifugalize, and concentrating under reduced pressure becomes flowing soaking paste, adds 3 times of methanol, left standstill behind the mix homogeneously 24 hours, Separation and Recovery methanol is left and taken the insoluble part of methanol, and cold preservation is standby; (2) get the Radix Astragali and add ultrafiltration water soak at room temperature 60 minutes, high-temp extracting 3 times, each lixiviate 1.5 hours, 1.2 hours, 1 hour merges 3 times filtrate, the centrifugal supernatant of collecting; (3) the insoluble extractum of cold preservation Stigma Maydis methanol is fully mixed in Radix Astragali centrifuged supernatant, filter pure clear liquid, concentrating under reduced pressure is to 1000g, add 2 times of 90% ethanol, the cold preservation precipitation was filtered in 24 hours, filtrate concentrating reclaimed ethanol, concentrated solution adds 2 times of amount 90% ethanol again, the cold preservation precipitation was filtered in 24 hours, and filtrate concentrates and reclaim ethanol, to there not being alcohol fully, add the 10ml benzyl alcohol, and add distilled water to full dose, and adding vitamin c, fine straining promptly gets Chinese medicine injection to 1000ml, sterilization in 100 ℃, 30 minutes.