CN111514249A - Composition for improving immunity and preparation method thereof - Google Patents

Composition for improving immunity and preparation method thereof Download PDF

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Publication number
CN111514249A
CN111514249A CN202010446965.9A CN202010446965A CN111514249A CN 111514249 A CN111514249 A CN 111514249A CN 202010446965 A CN202010446965 A CN 202010446965A CN 111514249 A CN111514249 A CN 111514249A
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composition
selenium
extract
parts
rich
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CN202010446965.9A
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Chinese (zh)
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肖志龙
米长江
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Beijing Xige Selenium Biotechnology Co ltd
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Beijing Xige Selenium Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a composition for improving immunity and a preparation method thereof, and relates to the field of functional foods. The present invention provides a composition comprising: organic selenium, astragalus root, corn stigma and other components. The invention obviously improves the immunity of the organism by adjusting the proportion of the organic selenium and the corn stigma. The composition has simple components, and no adverse side effect after long-term administration. The preparation method of the composition is simpler in process, and saves a large amount of time and cost.

Description

Composition for improving immunity and preparation method thereof
The technical field is as follows:
the invention relates to the field of functional foods, in particular to a composition for improving immunity and a preparation method thereof.
Background art:
selenium is a trace element necessary for human bodies, is an active component of glutathione peroxidase, and can enhance the activity of GPX by supplementing selenium, thereby enhancing the capacity of removing free radicals and oxidation resistance and protecting the normal structure and function of cell membranes, nucleic acid and proteins of organisms. Research shows that selenium affects body immunity and mainly comprises 3 immunity modes, namely cellular immunity, humoral immunity and non-specific immunity. Selenium can promote the production of interferon, increase the activity of gamma-interferon in vitro, and enhance the cytotoxic effect of human NK cells without damaging target cell membranes. Selenium can also promote the secretion capacity of lymphocytes IL-1 and IL-2 to be obviously enhanced, stimulate the formation of immunoglobulin and improve the capacity of an organism for synthesizing antibodies such as IgG, IgM and the like. In addition, selenium has varying degrees of influence on the chemotaxis, phagocytosis and killing process of virions by phagocytes. Research shows that selenium and macrophage activating factor can cooperate to activate macrophage, so as to enhance antitumor activity and reduce the inhibition of macrophage on lymphocyte.
Radix astragali contains various microelements such as sucrose, polysaccharide, amino acids, folic acid and copper, and has effects of enhancing organism immunity, protecting liver, promoting urination, resisting aging, resisting stress, regulating blood sugar content, lowering blood pressure and broad antibacterial effect. The stigma Maydis has effects of reducing blood lipid, lowering blood pressure, reducing blood sugar, promoting urination, promoting bile flow, and stopping bleeding.
In order to solve the technical problems, the invention provides a composition with immunity enhancing effect and a preparation method thereof.
The invention content is as follows:
the invention aims to provide a composition for improving immunity and a preparation method thereof. The composition provided by the invention has the effect of enhancing immunity; the preparation method of the invention has simpler process and saves time and cost.
The composition for improving the immunity comprises the following components in parts by weight: 15-40 parts of organic selenium, 10-35 parts of astragalus extract and 10-35 parts of corn stigma extract.
The weight ratio of the organic selenium to the corn stigma is 1-2: 1;
the organic selenium is one of selenium-rich yeast, selenium carrageenan, selenium-rich shepherd's purse powder extract, selenium-rich cardamine powder extract, selenium-rich Chinese cabbage powder extract, selenium-rich cabbage powder extract and selenium-rich malt powder extract.
The preparation method comprises the following steps:
(1) respectively pulverizing organic selenium, radix astragali extract and stigma Maydis extract, and sieving with 100 mesh sieve to obtain corresponding raw material powder;
(2) mixing the raw material powder, and stirring to obtain the composition for improving immunity.
The composition can be used for preparing powder, granules, tablets or capsules.
The invention has the beneficial effects that:
the invention provides a composition for improving immunity and a preparation method thereof, and the composition has simple components, has no side effect after long-term administration, and has the effect of enhancing the immunity of organisms. The invention obviously improves the effect of improving the immunity by adjusting the proportion of the organic selenium and the corn stigma. The preparation method of the composition is simpler in process, and saves a large amount of time and cost.
Detailed Description
In order to make the technical means, the original characteristics, the achieved purposes and the effects of the invention easily understood, the invention is further explained with the following embodiments, but the following embodiments are only the preferred embodiments of the invention, and not all embodiments. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention.
The experimental methods in the following examples are conventional methods unless otherwise specified, and materials, reagents and the like used in the following examples are commercially available unless otherwise specified.
Example 1
The composition for improving the immunity comprises the following components in parts by weight: 15 parts of organic selenium, 35 parts of astragalus extract and 10 parts of corn stigma extract. The organic selenium is selenium-rich malt powder extract.
The preparation method of the composition for improving immunity comprises the following steps:
(1) respectively pulverizing organic selenium, radix astragali extract and stigma Maydis extract, and sieving with 100 mesh sieve to obtain corresponding raw material powder;
(2) and (3) taking the raw material powder, mixing and uniformly stirring to obtain the composition for improving the immunity. The composition can be made into powder, granule, tablet, and capsule by conventional method.
Example 2
The composition for improving the immunity comprises the following components in parts by weight: 25 parts of organic selenium, 30 parts of astragalus extract and 25 parts of corn stigma extract. The organic selenium is selenium-rich malt powder extract.
The preparation method of the composition for improving immunity is the same as that of the embodiment 1.
Example 3
The composition for improving the immunity comprises the following components in parts by weight: 40 parts of organic selenium, 10 parts of astragalus root for improving immunity and 35 parts of corn stigma for improving immunity. The organic selenium is selenium-rich shepherd's purse powder extract.
The preparation method of the composition for improving immunity is the same as that of the embodiment 1.
Example 4
The composition for improving the immunity comprises the following components in parts by weight: 25 parts of organic selenium, 20 parts of astragalus and 35 parts of corn stigma. The organic selenium is selenium-rich shepherd's purse powder extract.
The preparation method of the composition for improving immunity is the same as that of the embodiment 1.
Example 5
The composition for improving the immunity comprises the following components in parts by weight: 40 parts of organic selenium, 35 parts of astragalus extract and 20 parts of corn stigma extract. The organic selenium is selenium-rich shepherd's purse powder extract.
The preparation of the above composition was the same as in example 1.
Example 6
The composition for improving the immunity comprises the following components in parts by weight: 30 parts of organic selenium, 20 parts of astragalus extract and 35 parts of corn stigma extract. The organic selenium is selenium-rich shepherd's purse powder extract.
The preparation of the above composition was the same as in example 1.
Example 7
The composition for improving the immunity comprises the following components in parts by weight: 35 parts of organic selenium, 30 parts of astragalus extract and 25 parts of corn stigma extract. The organic selenium is selenium-rich shepherd's purse powder extract.
The preparation of the above composition was the same as in example 1.
Example 8
A composition for improving immunity, which is different from the composition in example 7 only in that 30 parts of organic selenium and 30 parts of corn stigma extract; namely, the weight ratio of the organic selenium to the corn stigma is 1: 1.
The preparation of the above composition was the same as in example 1.
Example 9
A composition for improving immunity, which is different from the composition in example 7 only in that 40 parts of organic selenium and 20 parts of corn stigma extract; namely, the weight ratio of the organic selenium to the corn stigma is 2: 1.
The preparation of the above composition was the same as in example 1.
Comparative example 1
A composition for improving immunity is different from the composition of example 7 only in that organic selenium is not added.
The preparation of the above composition was the same as in example 1.
Comparative example 2
A composition for improving immunity, which is different from example 7 only in that no Astragalus membranaceus extract was added.
The preparation of the above composition was the same as in example 1.
Comparative example 3
An immunity enhancing composition differing from example 7 only in that no extract of corn silk was added.
The preparation of the above composition was the same as in example 1.
Test 1
Experiment for enhancing immunity of organism:
the experimental animals select 150 SPF Kunming white mice with the weight of 18-22 g.
The test samples were powders of the compositions prepared according to the formulations of examples 1 to 9 of the present invention and comparative examples 1 to 3, and the mouse was administered at a dose of 1.5 g/kg. Freely drinking water and eating, observing and adapting for 5 days before animal experiment, and entering into formal experiment after reexamination is qualified.
(1) Grouping experiments: the mice were randomly and evenly divided into groups, i.e., 10 mice each of which was perfused with the mice of examples 1-9 and comparative examples 1-3 and the mice of the control group, which was perfused with physiological saline. The compositions of examples 1-9 and comparative examples 1-3 were administered to groups of mice of examples 1-9 and comparative examples 1-3 daily with 1mL of physiological saline at a dose of 1.5g/kg BW/day for the entire experimental period; the saline control group was administered 1mL of saline daily. The mice freely eat and drink water, water is changed every day in the breeding process, and wood chip padding in the cage is changed every other day to keep cleanness. The ambient temperature is 20-25 ℃ and the total 15 days from the beginning of the gavage to the end of the experiment.
(2) Preparation of mouse serum: 24 hours after the last gastric lavage, 1-2mL of blood is collected from the eye socket after the eyeballs of the mice in each group are removed, the mice are placed in a test tube with anticoagulation in advance and are centrifuged at 3000rpm for 10min, and the supernatant is taken as the serum to be detected for later use.
(3) Measurement indexes and methods: lysozyme is a component of the immune defense mechanism of normal organisms, exists in neutrophils, monocytes and macrophages, and also exists in mucosal secretion, and is one of the body surface defense factors. The lysozyme content in the serum of each group of mice was measured using a Lysozyme (LZM) test kit (with standards), and the average value was calculated, and the measurement results are shown in Table 1.
Table 1: serum lysozyme content of each group of mice
Figure BDA0002506194250000051
Figure BDA0002506194250000061
As can be seen from Table 3, the serum lysozyme content of the mice gavaged with the compositions of examples 1-9 in Table 3 is higher than that of the mice of the normal saline control group, which indicates that the compositions of examples 1-9 of the present invention have the effect of enhancing the immunity of the organism, and the appropriate amount of the radix astragali extract and the corn silk extract are used in combination, so that the effect of enhancing the immunity can be significantly improved. In particular, the composition described in example 7 was most effective in enhancing immunity.
The raw material composition of the present invention, which is neither random nor any combination, is a composition that has been determined by the applicant through years of clinical application and research in combination with animal experiments, and cannot be considered as a simple superposition of raw materials having the same or similar effects; the pharmaceutical composition or the composition with the health care function is not simply combined and cannot be naturally compounded, but can be determined by scientific and creative tests; it has been proved by research that researchers who consider such ideas or practices as simple overlays, etc., have shown various problems in later development, production, application, and various adverse evaluations given by patients, including but not limited to various adverse reactions, etc., which are well-documented.
The foregoing is a preferred embodiment of the present invention, and is not intended to limit the invention in any way, so that modifications and equivalents may be made thereto without departing from the spirit and scope of the invention.
The selenium content in the selenium-rich extract is 50-4000 mug/g.
The sources of the raw materials of the invention are shown in table 2.
Table 2 sources of the invention
Figure BDA0002506194250000071
The foregoing is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification and equivalent changes made to the above embodiment according to the technical spirit of the present invention, without departing from the content of the technical solution of the present invention, are within the scope of the technical solution of the present invention.

Claims (5)

1. The composition for improving immunity is characterized by comprising the following components in parts by weight: 15-40 parts of organic selenium, 10-35 parts of astragalus extract and 10-35 parts of corn stigma extract.
2. The composition for improving immunity according to claim 1, wherein the weight ratio of the organic selenium to the corn silk is 1-2: 1.
3. The composition for improving immunity according to claim 1, wherein the organic selenium is one of selenium-rich yeast, selenium-rich carrageenan, selenium-rich shepherd's purse powder extract, selenium-rich cardamine powder extract, selenium-rich Chinese cabbage powder extract, selenium-rich cabbage powder extract and selenium-rich malt powder extract.
4. A method of preparing the composition for enhancing immunity according to claim 1, wherein the method comprises the steps of:
(1) respectively pulverizing organic selenium, radix astragali extract and stigma Maydis extract, and sieving with 100 mesh sieve to obtain corresponding raw material powder;
(2) mixing the raw material powder, and stirring to obtain the composition for improving immunity.
5. Use of a composition according to any of claims 1-4, wherein the composition is used to form a powder, granules, tablets or capsules.
CN202010446965.9A 2020-05-25 2020-05-25 Composition for improving immunity and preparation method thereof Pending CN111514249A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1237433A (en) * 1998-06-03 1999-12-08 杨学忠 Chinese medicine prescription and its preparation method
CN104082820A (en) * 2014-06-10 2014-10-08 秋实草业有限公司 Hypoglycemic soluble granules containing alfalfa
CN104799067A (en) * 2015-04-08 2015-07-29 辽宁禾丰牧业股份有限公司 Climbing feed for improving reproductive performance of commodity laying hens and preparation method of climbing feed

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1237433A (en) * 1998-06-03 1999-12-08 杨学忠 Chinese medicine prescription and its preparation method
CN104082820A (en) * 2014-06-10 2014-10-08 秋实草业有限公司 Hypoglycemic soluble granules containing alfalfa
CN104799067A (en) * 2015-04-08 2015-07-29 辽宁禾丰牧业股份有限公司 Climbing feed for improving reproductive performance of commodity laying hens and preparation method of climbing feed

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
李升和，等: "有机硒在人和动物应用方面的研究进展", 《安徽科技学院学报》 *
陈长兰，等: "硒对人体的作用机理及科学补硒方法 ", 《辽宁大学学报(自然科学版)》 *

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