CN104431686A - Selenium-enriched colla corii asini inulin chewable tablet and preparation method thereof - Google Patents
Selenium-enriched colla corii asini inulin chewable tablet and preparation method thereof Download PDFInfo
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- CN104431686A CN104431686A CN201410728877.2A CN201410728877A CN104431686A CN 104431686 A CN104431686 A CN 104431686A CN 201410728877 A CN201410728877 A CN 201410728877A CN 104431686 A CN104431686 A CN 104431686A
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- inulin
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- hide gelatin
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- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 42
- 239000011669 selenium Substances 0.000 title claims abstract description 42
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 37
- 229940057701 inulin chewable tablet Drugs 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 108010052008 colla corii asini Proteins 0.000 title abstract 8
- 239000002994 raw material Substances 0.000 claims abstract description 35
- 229920001202 Inulin Polymers 0.000 claims abstract description 20
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 20
- 229940029339 inulin Drugs 0.000 claims abstract description 20
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
- 239000000811 xylitol Substances 0.000 claims description 6
- 235000010447 xylitol Nutrition 0.000 claims description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
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- XYUNNDAEUQFHGV-UHFFFAOYSA-N [Se].[Se] Chemical compound [Se].[Se] XYUNNDAEUQFHGV-UHFFFAOYSA-N 0.000 claims description 5
- 235000009508 confectionery Nutrition 0.000 claims description 5
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 4
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 235000020985 whole grains Nutrition 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000019634 flavors Nutrition 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 240000009088 Fragaria x ananassa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
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- 206010012601 diabetes mellitus Diseases 0.000 abstract description 8
- 229920001282 polysaccharide Polymers 0.000 abstract description 7
- 239000005017 polysaccharide Substances 0.000 abstract description 7
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 4
- 239000008103 glucose Substances 0.000 abstract description 4
- 230000007812 deficiency Effects 0.000 abstract description 2
- 229940068682 chewable tablet Drugs 0.000 abstract 1
- 235000013409 condiments Nutrition 0.000 abstract 1
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- 241000699666 Mus <mouse, genus> Species 0.000 description 6
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- 238000000034 method Methods 0.000 description 3
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- 108700016172 Glutathione peroxidases Proteins 0.000 description 2
- 206010018473 Glycosuria Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 240000005373 Panax quinquefolius Species 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
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- 208000024891 symptom Diseases 0.000 description 2
- RFSUNEUAIZKAJO-VRPWFDPXSA-N D-Fructose Natural products OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-VRPWFDPXSA-N 0.000 description 1
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
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- 208000005374 Poisoning Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
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- 235000008434 ginseng Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
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- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a selenium-enriched colla corii asini inulin chewable tablet and a preparation method thereof. The selenium-enriched colla corii asini inulin chewable tablet is prepared by the following steps: sequentially pre-treating raw materials; uniformly mixing; granulating; drying; straightening and tabletting by taking organic selenium, colla corii asini and inulin as main effective components which are assisted by a condiment, a filler, a lubricant and the like. The selenium-enriched colla corii asini inulin chewable tablet specifically comprises the following components in percentage by mass: 5-15% of colla corii asini, 25-40% of inulin, 0.1-0.5% of organic selenium (the content of selenium in the organic selenium is 1%), 10-35% of a corrigent, 5-20% of the filler, 5-20% of a sweetening agent and 0.3-2% of a lubricant. The preparation method comprises the following steps: pre-treating the raw materials; granulating; straightening; and tabletting. The selenium-enriched colla corii asini inulin chewable tablet disclosed by the invention has the beneficial effects that (1) the chewable tablet which serves as a common preparation has the advantages of being accurate to meter, good in stability, convenient to carry and eat and the like; (2) not only are the functions of original components retained, but also the deficiency that the raw materials are independently eaten is overcome; and (3) as the raw materials contain se-polysaccharide and inulin, the product disclosed by the invention not only can exert the function of colla corii asini, but also can achieve a better effect of reducing the blood glucose, thereby being beneficial for the diabetes to take.
Description
Technical field
The present invention relates to a kind of chewable tablets, is a kind of donkey-hide gelatin inulin chewable tablet and preparation method thereof specifically.
Background technology
Donkey-hide gelatin is the solid gum that the dry hide of donkey or fresh hide are made through decocting and concentrating, with ginseng, pilose antler being called " nourishing Triratna ".The sweet property of donkey-hide gelatin taste is put down, and returns lung liver kidney channel, is respectfully called enrich blood " panacea " by ancient Chinese medicine doctor.Donkey-hide gelatin contains 18 seed amino acids, wherein the amino acid of 8 kinds of needed by human.Modern study confirms, donkey-hide gelatin has good blood tonification effect to deficiency of blood animal, is better than chalybeate to the curative effect of hemoglobin and red blood cell growth rate, has the effect promoting immune function of human body, improve the health.In addition, donkey-hide gelatin can also antiabortive, the strengthening the muscles and bones of menstruation regulating, improving water flood, raising immunity.But due to the limitation of existing manufacture craft, newly formed donkey-hide gelatin always with some fire poison, thus enters to take new fresh Donkey-hide Glue and people can be made to produce the high Sheng of internal heat and various poisoning symptom, cause the dry pain of throat and the symptom such as constipation or stool band blood.In addition, in order to be in harmonious proportion the mouthfeel of donkey-hide gelatin, generally needing to add a large amount of sucrose or other carbohydrates that blood sugar for human body can be caused to raise, make diabetes patient or cannot take the crowd of glucose sensitive, limiting the scope of application of donkey-hide gelatin.Current donkey-hide gelatin has had the multiple formulation such as oral liquid, granule to appear at health products ranks, does not also have chewable tablets of donkey-hide gelatin to occur.
Summary of the invention
The object of this invention is to provide a kind of rich selenium donkey-hide gelatin inulin chewable tablet and preparation method, for achieving the above object, adopt following technical scheme:
A kind of rich selenium donkey-hide gelatin inulin chewable tablet, with Organic Selenium, donkey-hide gelatin, inulin for mainly containing effective constituent, being aided with flavor enhancement, filler, lubricant etc., obtaining rich selenium chewable tablets of donkey-hide gelatin successively through pretreatment of raw material, mixing, granulation, drying, whole grain, compressing tablet; Concrete formula (mass fraction) is as follows: donkey-hide gelatin: 5-15%; Inulin: 25-40%; Organic Selenium: 0.1-0.5%, described Organic Selenium selenium content: 0.8-1.2%; Flavouring: 10-35%; Filler: 5-20%; Sweetener: 5-20%; Lubricant: 0.3-2%.
Described flavouring be fruit powder, as the one in apple powder, lemon powder, strawberry powder etc. and more than;
Described filler be one in pregelatinized starch, lactose, dextrin etc. and more than;
Described sweetener be one in xylitol, sweet mellow wine, maltose etc. and more than;
Described lubricant be one in dolomol, talcum powder, microcrystalline cellulose etc. and more than.
The present invention further discloses a kind of method preparing described rich selenium donkey-hide gelatin inulin chewable tablet, concrete operation step is:
(1) pretreatment of raw material
By raw materials used under the condition of 40-50 DEG C, drying is no less than 24h, and the moisture in control raw material is below 5%, and the environment being placed in hermetically drying is for subsequent use;
(2) granulation
Mixed according to proportioning by raw material, spray into the alcohol that volume fraction is 95% while stirring, alcoholic solution addition is the 20-30% of quality of material, is stirred to grain forming;
(3) whole grain
The granular product obtained in step (2) is placed in constant temperature oven, dry 2-4h at 25-45 DEG C, to the water content in product not higher than 5%.First dried product crosses 20 object sieves, removes larger caking, after 80 object sieves, removes the powder of non-granulating;
(4) compressing tablet
In the product in step (3), add lubricant, after mixing, carry out compressing tablet.The chewable tablets obtained is placed in dry environment sealing and preserves.
Selenium is the coenzyme of glutathione peroxidase, plays vital effect to maintaining the activity of glutathione peroxidase, and selenium polysaccharide has hypoglycemic, to improve immunity of organisms, antitumor, anti-ageing and removing toxic substances effect.
Inulin, has another name called synanthrin, is the chain polysaccharide be formed by connecting through β (1 → 2) glycosidic bond by D-Fructose, and end is often containing a glucosyl group.Inulin is present in many plants as a kind of energy reserve material except starch, is hydrolyzed hardly and digests by hydrochloric acid in gastric juice, is used as nutriment, has the feature of probiotic in colon by a large amount of beneficial microbe.Meanwhile, inulin also has control blood fat, does not cause blood glucose fluctuation, promotes mineral absorption, prevents physiological functions such as treating constipation.
Beneficial effect of the present invention: (1) chewable tablets, as a kind of common dosage forms, has accurate measurement, good stability, easy to carry, be convenient to advantages such as eating.(2) formula of the present invention, had both remained effect of original composition, reasonably combined again by between raw material, overcome raw material edible separately time shortcoming, such as, have fishy smell when donkey-hide gelatin is edible separately, products taste of the present invention is then better; For the crowd that some physique are more weak, edible donkey-hide gelatin easily causes constipation separately, and inulin has the effect for the treatment of constipation.(3) mouse test results shows, due in raw material containing selenium polysaccharide and inulin, the function that product of the present invention can either play donkey-hide gelatin can reach again falls hypoglycemic effect preferably, is beneficial to diabetic to take.
Detailed description of the invention:
Embodiment 1:
By the raw material dry 24h in the thermostatic drying chamber of 40 DEG C required for production, be then placed in dry environment sealing and preserve with for subsequent use.According to 5 grams, donkey-hide gelatin, inulin 40 grams, Organic Selenium 0.1 gram (described Organic Selenium selenium content: 0.8%), raw material mixes by the ratio of apple powder 10 grams, xylitol 5 grams, pregelatinized starch 20 grams, the ethanol that volume fraction is 95% is sprayed in mixture, alcohol addition is 20% of raw material gross mass, is stirred to grain forming.Granular product is placed in the dry 2h of drying box of 25 DEG C.First dried mixture crosses 20 object sieves, removes larger caking, after 80 object sieves, removes the powder of non-granulating.In dried particle, add the dolomol of 0.5g, carry out compressing tablet after mixing, the rich selenium chewable tablets of donkey-hide gelatin obtained is faint yellow, uniform color, and form is complete, smooth surface, and chewiness is good, and the quality of monolithic is 0.25g, and hardness is 50N.
Embodiment 2:
By the raw material dry 24h in the thermostatic drying chamber of 45 DEG C required for production, be then placed in dry environment sealing and preserve with for subsequent use.According to 10 grams, donkey-hide gelatin, inulin 35 grams, Organic Selenium 0.2 gram (described Organic Selenium selenium content is 1.2%), raw material mixes by the ratio of lemon powder 25 grams, 10 grams, sweet mellow wine, lactose 5 grams, the ethanol that volume fraction is 95% is sprayed in mixture, alcohol addition is 30% of raw material gross mass, is stirred to grain forming.Granular product is placed in the dry 3h of drying box of 30 DEG C.First dried mixture crosses 20 object sieves, removes larger caking, after 80 object sieves, removes the powder of non-granulating.In dried particle, add the talcum powder of 1g, carry out compressing tablet after mixing, the rich selenium chewable tablets of donkey-hide gelatin obtained is faint yellow, uniform color, and form is complete, smooth surface, and chewiness is good, and the quality of monolithic is 0.28g, and hardness is 52N.
Embodiment 3:
By the raw material dry 24h in the thermostatic drying chamber of 50 DEG C required for production, be then placed in dry environment sealing and preserve with for subsequent use.According to the ratio of 15 grams, donkey-hide gelatin, inulin 25 grams, Organic Selenium 0.5 gram, strawberry powder 35 grams, xylitol 20 grams, pregelatinized starch 15 grams, raw material is mixed, the ethanol that volume fraction is 95% is sprayed in mixture, alcohol addition is 25% of raw material gross mass, is stirred to grain forming.Granular product is placed in the dry 4h of drying box of 45 DEG C.First dried mixture crosses 20 object sieves, removes larger caking, after 80 object sieves, removes the powder of non-granulating.In dried particle, add the dolomol of 2g, carry out compressing tablet after mixing, the rich selenium chewable tablets of donkey-hide gelatin obtained is faint yellow, uniform color, and form is complete, smooth surface, and chewiness is good, and the quality of monolithic is 0.3g, and hardness is 52N.
Embodiment 4:
By the raw material dry 24h in the thermostatic drying chamber of 40 DEG C required for production, be then placed in dry environment sealing and preserve with for subsequent use.According to 5 grams, donkey-hide gelatin, inulin 40 grams, Organic Selenium 0.1 gram (described Organic Selenium selenium content: 1%), raw material mixes by the ratio of lemon powder 10 grams, strawberry powder 20 grams, maltose 20 grams, pregelatinized starch, lactose, each 5 grams of dextrin, the ethanol that volume fraction is 95% is sprayed in mixture, alcohol addition is 20% of raw material gross mass, is stirred to grain forming.Granular product is placed in the dry 2h of drying box of 25 DEG C.First dried mixture crosses 20 object sieves, removes larger caking, after 80 object sieves, removes the powder of non-granulating.In dried particle, add the microcrystalline cellulose of 0.3g, carry out compressing tablet after mixing, the rich selenium chewable tablets of donkey-hide gelatin obtained is faint yellow, uniform color, and form is complete, smooth surface, and chewiness is good, and the quality of monolithic is 0.25g, and hardness is 50N.
Embodiment 5:
By the raw material dry 24h in the thermostatic drying chamber of 40 DEG C required for production, be then placed in dry environment sealing and preserve with for subsequent use.According to the ratio of 5 grams, donkey-hide gelatin, inulin 40 grams, Organic Selenium 0.1 gram, apple powder 15 grams, lemon powder 5 grams, strawberry powder 5 grams, xylitol, sweet mellow wine, each 5 grams of maltose, pregelatinized starch, each 10 grams of lactose, raw material is mixed, the ethanol that volume fraction is 95% is sprayed in mixture, alcohol addition is 20% of raw material gross mass, is stirred to grain forming.Granular product is placed in the dry 2h of drying box of 25 DEG C.First dried mixture crosses 20 object sieves, removes larger caking, after 80 object sieves, removes the powder of non-granulating.In dried particle, add the dolomol of 0.3g, 0.2g talcum powder, 0.1g microcrystalline cellulose, carry out compressing tablet after mixing, the rich selenium chewable tablets of donkey-hide gelatin obtained is faint yellow, uniform color, form is complete, smooth surface, chewiness is good, and the quality of monolithic is 0.25g, and hardness is 50N.
Comparative example
By the raw material dry 24h in the thermostatic drying chamber of 40 DEG C required for production, be then placed in dry environment sealing and preserve with for subsequent use.According to the ratio of 8 grams, donkey-hide gelatin, apple powder 15 grams, xylitol 15 grams, pregelatinized starch, each 10 grams of lactose, raw material is mixed, the ethanol that volume fraction is 95% is sprayed in mixture, alcohol addition is 20% of raw material gross mass, is stirred to grain forming.Granular product is placed in the dry 2h of drying box of 25 DEG C.First dried mixture crosses 20 object sieves, removes larger caking, after 80 object sieves, removes the powder of non-granulating.In dried particle, add the dolomol of 0.3g, 0.2g talcum powder, 0.1g microcrystalline cellulose, carry out compressing tablet after mixing, the rich selenium chewable tablets of donkey-hide gelatin obtained is faint yellow, uniform color, and form is complete,
Supplement herein and prepare example into donkey-hide gelatin group, such as, donkey-hide gelatin group is only donkey-hide gelatin, not containing selenium polysaccharide and inulin.Prove to invention increases with this effect that selenium polysaccharide and inulin have 1+1 > 2, thus creative.
Using the product of embodiment 1 as sample sets, comparative example is donkey-hide gelatin group, and mouse test results is as follows:
Table 1 is the impact that inventive samples changes Mouse Weight
Table 1
▲ p<0.05, compares with diabetic model group
Sample sets Mouse Weight, in gavage process visible obviously increase afterwards in 30 days, compares with glycosuria model group and has statistical significance, infer that sample sets has the effect slowing down diabetic mice body weight and alleviate.
Table 2 is the impact that inventive samples changes mouse blood sugar
Table 2
P<0.05, compares with diabetic model group
Compare with glycosuria model group, donkey-hide gelatin group, sample sets and melbine group mouse gavage process after 30 days random blood sugar all have reduction, difference has statistical significance, and the effect that sample sets reduction blood glucose in diabetic mice and the diabetic mice body weight that slows down alleviate is remarkable, suitable with melbine effect.
From Table 1 and Table 2, in donkey-hide gelatin, add selenium polysaccharide and inulin, there is the effect of 1+1 > 2.
Claims (6)
1. a rich selenium donkey-hide gelatin inulin chewable tablet, it is characterized in that: with Organic Selenium, donkey-hide gelatin, inulin for mainly containing effective constituent, be aided with flavor enhancement, filler, lubricant etc., obtain rich selenium chewable tablets of donkey-hide gelatin through pretreatment of raw material, mixing, granulation, drying, whole grain, compressing tablet successively; Concrete formula (mass fraction) is as follows: donkey-hide gelatin: 5-15%; Inulin: 25-40%; Organic Selenium: 0.1-0.5%, described Organic Selenium selenium content: 0.8-1.2%; Flavouring: 10-35%; Filler: 5-20%; Sweetener: 5-20%; Lubricant: 0.3-2%.
2. rich selenium donkey-hide gelatin inulin chewable tablet according to claim 1, is characterized in that: described flavouring for fruit powder, as the one in apple powder, lemon powder, strawberry powder etc. and more than.
3. rich selenium donkey-hide gelatin inulin chewable tablet according to claim 1, is characterized in that: described filler be one in pregelatinized starch, lactose, dextrin etc. and more than.
4. rich selenium donkey-hide gelatin inulin chewable tablet according to claim 1, is characterized in that: described sweetener be one in xylitol, sweet mellow wine, maltose etc. and more than.
5. rich selenium donkey-hide gelatin inulin chewable tablet according to claim 1, is characterized in that: described lubricant be one in dolomol, talcum powder, microcrystalline cellulose etc. and more than.
6. a preparation method for rich selenium donkey-hide gelatin inulin chewable tablet according to claim 1, is characterized in that: concrete operation step is:
(1) pretreatment of raw material
By raw materials used under the condition of 40-50 DEG C, drying is no less than 24h, and the moisture in control raw material is below 5%, and the environment being placed in hermetically drying is for subsequent use;
(2) granulation
Mixed according to proportioning by raw material, spray into the alcohol that volume fraction is 95% while stirring, alcoholic solution addition is the 20-30% of quality of material, is stirred to grain forming;
(3) whole grain
The granular product obtained in step (2) is placed in constant temperature oven, dry 2-4h at 25-45 DEG C, to the water content in product not higher than 5%.First dried product crosses 20 object sieves, removes larger caking, after 80 object sieves, removes the powder of non-granulating;
(4) compressing tablet
In the product in step (3), add lubricant, after mixing, carry out compressing tablet.The chewable tablets obtained is placed in dry environment sealing and preserves.
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| CN106616966A (en) * | 2016-09-07 | 2017-05-10 | 烟台康美生物科技有限公司 | Lipid-lowering chewable tablets and preparation method thereof |
| CN106666752A (en) * | 2016-12-23 | 2017-05-17 | 南京糖防生物科技有限公司 | Donkey-hide gelatin composition and preparation method thereof |
| CN106805065A (en) * | 2017-01-24 | 2017-06-09 | 北京首诚航天农业生物科技有限公司 | A kind of inulin selenium-rich solid beverage |
| CN106962901A (en) * | 2017-04-26 | 2017-07-21 | 明松 | A kind of product formula and its technique rich in Organic Selenium |
| CN107897875A (en) * | 2017-11-16 | 2018-04-13 | 广州市健鸣春生物科技有限公司 | It is a kind of to be used to improve Se-enriched yeast zinc metal sheet of sperm quality and vigor and preparation method thereof |
| CN109275907A (en) * | 2018-08-09 | 2019-01-29 | 福建农林大学 | A kind of lemon tea polyphenols chewable tablets and preparation method thereof |
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Application publication date: 20150325 |