CN104606659A - Antimicrobial and antiviral oral liquid for regulating metabolism and enhancing immunity - Google Patents
Antimicrobial and antiviral oral liquid for regulating metabolism and enhancing immunity Download PDFInfo
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- CN104606659A CN104606659A CN201510062479.6A CN201510062479A CN104606659A CN 104606659 A CN104606659 A CN 104606659A CN 201510062479 A CN201510062479 A CN 201510062479A CN 104606659 A CN104606659 A CN 104606659A
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Abstract
The invention discloses an antimicrobial and antiviral oral liquid for regulating metabolism and enhancing immunity. The oral liquid is prepared from cordyceps militaris, carrageenan-derived oligosaccharides, sea-fish collagen oligopeptide powder, fresh ginger, jujube, liquorice, astragalus membranaceus, honey, citric acid, aspartame, potassium sorbate and water. The preparation technology comprises the following steps: crushing cordyceps militaris through an 80-mesh sieve, and putting into an enzymatic vessel according to the formula ratio; adding 20fold water, adding 1.5-3.0 parts of 500,000U/g cellulase, and carrying out enzymolysis for 4 hours at 38-43 DEG C; adding carrageenan-derived oligosaccharides and mixing with aspartame evenly; carrying out enzyme deactivation at 90-100 DEG C for 30 minutes, and simultaneously, continuously stirring; extracting fresh ginger, jujube, liquorice and astragalus membranaceus with 6-8fold water for 90 minutes, and filtering; mixing enzymatic hydrolysate with a traditional Chinese medicine extract liquid, adding sea-fish collagen oligopeptide powder, honey, citric acid and potassium sorbate, heating to 60 DEG C, and simultaneously, continuously stirring to mix evenly; and filtering through a 0.22micron filter membrane, and filling to obtain the antimicrobial and antiviral oral liquid. The preparation disclosed by the invention can be applied to prevention of hypertension, hyperglycemia, tumor and the like caused by metabolic disturbance, and cough, infection, fatigue and the like caused by hypoimmunity.
Description
Technical field
The present invention relates to a kind of combination formula, for antibacterial, antiviral, adjustment metabolism, strengthen immunity.
Background technology
In society's development process, air pollution is also more and more serious, and industrial discharge, vehicle exhaust, building airborne dust, waste incineration etc. make air quality worse and worse, and the frequency that haze weather is occurred is more and more higher.Kind more than 20 is reached containing various harmful fine grained, noxious substance inside haze, include acid, alkali, dust, influenza virus, tubercule bacillus, streptococcus pneumoniae etc., they invade in human respiratory tract and the lobe of the lung when people have no to take precautions against, thus cause the diseases such as respiratory system disease, cardiovascular system diseases, blood system, reproductive system, the inflammation such as such as pharyngolaryngitis, emphysema, asthma, rhinitis, bronchitis, are in this environment for a long time and also can bring out pulmonary carcinoma, myocardial ischemia and damage.Simultaneously along with the change of people life style, rhythm of life is also more and more faster, body metabolism disorder becomes the key factor affecting people's orthobiosis, the sickness rate of hypertension, diabetes and tumor increases considerably, for solving the problem, being necessary to develop a kind of antibacterial, antiviral, adjustment metabolism, strengthening the comprehensive preparation of immunity, to improving the quality of life of people, reducing the generation of disease.
Summary of the invention
The invention provides a kind of antibacterial, antiviral, adjustment metabolism, strengthen the oral liquid of immunity, not only effective, and also cheap, taking convenience.
The technical solution adopted for the present invention to solve the technical problems is: a kind of antibacterial, antiviral, regulate metabolism, strengthen the oral liquid of immunity, it adopts Cordyceps militaris (L.) Link., Carrageenan sugar, marine fish collagen oligopeptide powder, Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Glycyrrhizae, the Radix Astragali, Mel, citric acid, aspartame, potassium sorbate, water is raw material, by following quality proportioning: Cordyceps militaris (L.) Link. 50 ~ 500 parts, Carrageenan sugar 5 ~ 50 parts, marine fish collagen oligopeptide powder 5 ~ 50 parts, 60 ~ 600 parts, Rhizoma Zingiberis Recens, 300 ~ 1500 parts, Fructus Jujubae, 200 ~ 1000 parts, Radix Glycyrrhizae, the Radix Astragali 200 ~ 1000 parts, Mel 30 ~ 200 parts, citric acid 10 ~ 30 parts, aspartame 5 ~ 10 parts, potassium sorbate 3 ~ 5 parts, 10000 ~ 50000 parts, water is made, and its preparation technology is: Cordyceps militaris (L.) Link. was pulverized 80 mesh sieves, and put into enzymatic vessel by formula ratio, adds the water of 20 times, adds 500,000 U/g cellulase 1.5 ~ 3.0 parts enzymolysis 4h under the condition of 38 ~ 43 DEG C, adds Carrageenan sugar, after aspartame mixing, enzyme denaturing 30min under 90 ~ 100 DEG C of conditions, constantly stirs simultaneously, by Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Glycyrrhizae, the Radix Astragali 6 ~ 8 times of water extraction 90 minutes, filter, enzymolysis solution is mixed with Chinese medicine extraction liquid, adds marine fish collagen oligopeptide powder, Mel, citric acid, potassium sorbate, be warming up to 60 DEG C, stir simultaneously constantly and make it mix homogeneously, then through 0.22 μm of membrane filtration, fill and get final product.
Part of the present invention is mass parts, is the mass unit such as microgram, milligram, gram, kilogram that this area is conventional.
It is 20 ~ 40ml that invention formulation suggestion takes effective dose day, divides and takes for 2 times.
The invention has the beneficial effects as follows: in this preparation, Cordyceps militaris (L.) Link., Carrageenan sugar, the Radix Astragali reach antibacterial and antiviral effect by suppressing virus and harmful bacteria to the infringement of human body; Cordyceps militaris (L.) Link., Carrageenan sugar, marine fish collagen oligopeptide powder, Fructus Jujubae, Rhizoma Zingiberis Recens have enhancing human body immunity power, regulate the effect of metabolism, slow down aging; Simultaneously by the invigorating the spleen and replenishing QI of Radix Glycyrrhizae, dispel and cough the effect of reducing phlegm and can reduce the injury that air pollution on human causes.Invention formulation can be used for the symptom such as hypertension, hyperglycemia, tumor of preventing metabolism disorder to cause, and the symptom such as flu, infection, fatigue that hypoimmunity causes.
Compound basis:
Cordyceps militaris (L.) Link. has another name called Cordyceps militaris (L.) Link., northern Cordyceps militaris (L.) Link. etc., by Stroma and sclerotium complex dimerous.The compositions such as cordycepin, cordycepic acid, adenosine, polysaccharide, selenium are rich in Cordyceps militaris (L.) Link..Wherein cordycepin can antiviral, the growth of antibacterial, obvious Tumor suppression, interference human body RNA and DNA synthesis; Cordycepic acid can effectively prophylactic treatment cerebral thrombosis, cerebral hemorrhage, renal failure, also has diuresis simultaneously; Adenosine can antiviral, antibacterial, suppresses Platelet congregation to prevent and treat thrombosis, also can eliminate speckle, anti-ageing wrinkle resistant; Cordyceps polysaccharide is improved immunity, slow down aging, strengthening the body resistance, cardioprotection, liver, the effect of spasmolytic; Ergosterol, superoxide dismutase, to suppression or eliminate and urge the superoxide radical of people's aging to be formed and anticancer, health care, attenuation have good action; Selenium can the growth of anticancer significantly, the generation of immune stimulatory globulin and antibody, enhancing human body immunity and oxidation resistance.
Carrageenan sugar utilizes carrageenase degraded carrageenan to obtain, relative carrageenan, Carrageenan sugar molecular weight, dissolubility are better, stability and safety all make moderate progress, simultaneously because the active group on strand fully exposes, its original activity is improved, and even creates new activity.Carrageenan sugar has the effects such as immunity moderation, antitumor, radioprotective, antibacterial and antiviral.The gelling of Carrageenan sugar and thicken the weight that effect significantly can increase immune organ, improves the content of immunity of organism IL-2 (interleukin) and TNF-α (tumor necrosis factor); Carrageenan sugar obviously can alleviate the reduction of radiation-induced spleen nk cell activity, the symptoms such as hemopoietic function is suppressed, blood cell source minimizing, improves body's immunity, has obvious protective action to radiation damage; Carrageenan sugar is adsorbed with inhibitory action to herpes simplex virus type 1 (HSV-1), and present obvious dose-effect relationship, find in the inhibitory action that Carrageenan sugar is bred broiler chicken intestinal, the experiment that promotes intestinal microvillus growth promoter and improve immunoreation and fertility performance, Carrageenan sugar has inhibitory action to escherichia coli in broiler chicken cecal content.
Marine fish collagen oligopeptide powder is that refine and process, relative molecular weight more than 85% is less than 1000U, is the food ingredient of novel nutrient health with the skin of pollution-free or that pollution is relatively little bathypelagic fish, bone for raw material.Can effectively keep skin young, slow down aging, and can endocrine regulation, protection and strengthening viscera function, binding domain-immunoglobulin, increases immunity.
The nutritional labelings such as Fructus Jujubae rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum and cyclic adenosine monophosphate.There is invigorating the spleen and replenishing QI, effect of nourishing blood to tranquillize the mind.Can be used for weakness of the spleen and stomach, deficiency of QI in middle-JIAO, fatigue and lack of strength, anorexia and loose stool; Blood deficiency fistula is yellow, become thin, the symptoms such as spirit is uneasy.Pharmacological research finds, containing various bioactivators in Fructus Jujubae, as jujube polysaccharide, flavonoid, saponins, triterpenes etc., has plurality kinds of health care to cure the disease effect to human body.Jujube polysaccharide has obvious complement activity and promotes Proliferation of lymphocytes, can improve immunity of organisms.Soap-like matter contained in Fructus Jujubae, has effects such as regulating body metabolism, enhancing immunity, antiinflammatory, antiallergic action.
Radix Glycyrrhizae main chemical compositions is glycyrrhizic acid, liquirtin etc., has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of relieving spasm to stop pain.Can be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the symptoms such as gastral cavity abdomen.Rhizoma Zingiberis Recens is warm in nature, acrid in the mouth.
Gingerol contained in Rhizoma Zingiberis Recens and the structure of diarylheptanoids all have very strong antioxidation and effect of scavenging radical; Function of tumor inhibition; Eat Rhizoma Zingiberis Recens energy defying age, old people often eats Rhizoma Zingiberis Recens can remove " senile plaque ".
The function of said preparation:
One, organism metabolism is regulated.
In invention formulation scalable body, the balance of saccharide, protein and fat, makes organism metabolism balance, and reduces the sickness rate of hypertension, hyperglycemia.
Two, there is antibacterial, antiviral effect.
In preparation, contained effective ingredient cordycepin and Carrageenan sugar all have antibacterial and antiviral effect, can effectively anti-bacteria and virus to the harm of human body.
Three, immunity of organisms is improved.
In preparation, contained Cordyceps polysaccharide is improved immunity, the effect of slow down aging; The gelling of Carrageenan sugar and thicken the weight that effect significantly can increase immune organ, improves the content of immunity of organism IL-2 (interleukin) and TNF-α (tumor necrosis factor); Jujube polysaccharide has obvious complement activity and promotes Proliferation of lymphocytes, and can improve immunity of organisms, all multicomponents share the effect jointly reaching enhancing human body immunity power.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1: a kind of antibacterial, antiviral, regulate metabolism, strengthen the oral liquid of immunity, adopt Cordyceps militaris (L.) Link. 300g, Carrageenan sugar 25g, marine fish collagen oligopeptide powder 25g, Rhizoma Zingiberis Recens 300g, Fructus Jujubae 800g, Radix Glycyrrhizae 500g, Radix Astragali 500g, Mel 100g, citric acid 20g, aspartame 6g, potassium sorbate 4g, water 18600g makes, its preparation technology is: Cordyceps militaris (L.) Link. was pulverized 80 mesh sieves, enzymatic vessel is put into by formula ratio, add the water of 20 times, add 500,000 U/g cellulase 2.0g enzymolysis 4h under the condition of 40 DEG C, add Carrageenan sugar, after aspartame mixing, enzyme denaturing 30min under 90 DEG C of conditions, constantly stir simultaneously, by Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Glycyrrhizae, the Radix Astragali 6 times of water extraction 90 minutes, filter, enzymolysis solution is mixed with Chinese medicine extraction liquid, adds marine fish collagen oligopeptide powder, Mel, citric acid, potassium sorbate, be warming up to 60 DEG C, stir simultaneously constantly and make it mix homogeneously, then through 0.22 μm of membrane filtration, fill and get final product.
Embodiment 2: a kind of antibacterial, antiviral, regulate metabolism, strengthen the oral liquid of immunity, adopt Cordyceps militaris (L.) Link. 100g, Carrageenan sugar 40g, marine fish collagen oligopeptide powder 10g, Rhizoma Zingiberis Recens 500g, Fructus Jujubae 1500g, Radix Glycyrrhizae 1000g, Radix Astragali 200g, Mel 200g, citric acid 10g, aspartame 10g, potassium sorbate 3g, water 27600g makes, its preparation technology is: Cordyceps militaris (L.) Link. was pulverized 80 mesh sieves, enzymatic vessel is put into by formula ratio, add the water of 20 times, add 500,000 U/g cellulase 1.5g enzymolysis 4h under the condition of 43 DEG C, add Carrageenan sugar, after aspartame mixing, enzyme denaturing 30min under 95 DEG C of conditions, constantly stir simultaneously, by Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Glycyrrhizae, the Radix Astragali 8 times of water extraction 90 minutes, filter, enzymolysis solution is mixed with Chinese medicine extraction liquid, adds marine fish collagen oligopeptide powder, Mel, citric acid, potassium sorbate, be warming up to 60 DEG C, stir simultaneously constantly and make it mix homogeneously, then through 0.22 μm of membrane filtration, fill and get final product.
Embodiment 3: a kind of antibacterial, antiviral, regulate metabolism, strengthen the oral liquid of immunity, adopt Cordyceps militaris (L.) Link. 500g, Carrageenan sugar 10g, marine fish collagen oligopeptide powder 50g, Rhizoma Zingiberis Recens 100g, Fructus Jujubae 1000g, Radix Glycyrrhizae 800g, Radix Astragali 800g, Mel 50g, citric acid 30g, aspartame 8g, potassium sorbate 5g, water 28900g makes, its preparation technology is: Cordyceps militaris (L.) Link. was pulverized 80 mesh sieves, enzymatic vessel is put into by formula ratio, add the water of 20 times, add 500,000 U/g cellulase 3.0g enzymolysis 4h under the condition of 43 DEG C, add Carrageenan sugar, after aspartame mixing, enzyme denaturing 30min under 95 DEG C of conditions, constantly stir simultaneously, by Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Glycyrrhizae, the Radix Astragali 7 times of water extraction 90 minutes, filter, enzymolysis solution is mixed with Chinese medicine extraction liquid, adds marine fish collagen oligopeptide powder, Mel, citric acid, potassium sorbate, be warming up to 60 DEG C, stir simultaneously constantly and make it mix homogeneously, then through 0.22 μm of membrane filtration, fill and get final product.
Embodiment 4:
Antibacterial tests:
Use the oral liquid of the present invention of preparation in embodiment 1, the antibacterial effect of this preparation is tested.
1. experimental animal: Kunming mouse, body weight 18 ~ 22g.
2. test grouping:
Get Kunming mouse 75, be divided into 5 groups at random, be respectively Normal group, saline control group, the high, medium and low dosage group (40ml/kg.bw, 20ml/kg.bw, 10m1/kg.bw) of invention formulation, often organize 15 animals.
3. test method
Normal group is with aquesterilisa gavage, saline control group is with normal saline gavage, invention formulation high, medium and low dosage group IG administration, after 4d, saline control group and the high, medium and low dosage component of invention formulation only do not inject minimum lethal dose bacteria suspension (staphylococcus aureus or streptococcus pneumoniae) 0.5ml/, continue IG administration 3d.Record dead mouse number, calculates each group of mouse death rate.In table 1.
Table 1 invention formulation is to the death prevention rate effect of staphylococcus aureus and streptococcus pneumoniae infection
Note: compare * P < 0.05, * * P < 0.01 with saline control group
Result shows, and invention formulation group compares with normal saline group, and mouse death rate obviously reduces, and dosage is higher, and mortality rate less (P < 0.01), as can be seen here, invention formulation has antibacterial effect.
Embodiment 5:
Antivirus test:
Use the oral liquid of the present invention of preparation in embodiment 2, the antiviral effect of this preparation is tested.
1. experimental animal: Kunming mouse, body weight 18 ~ 22g.
2. test grouping:
Get Kunming mouse 75, be divided into 5 groups at random, be respectively Normal group, model control group, the high, medium and low dosage group (40ml/kg.bw, 20ml/kg.bw, 10ml/kg.bw) of invention formulation, often organize 15 animals.
3. test method
Normal group is with the contrast of normal saline collunarium, and model control group, invention formulation group every mice infect with the influenza virus liquid 50 μ l collunarium of median lethal dose(LD 50).IG administration on the same day after modeling, every day 1 time, continuous 7d.Continuous Observation 14d from modeling same day, record dead mouse number, calculates each group of mouse death rate.In table 2.
Table 2 invention formulation infected by influenza infect mouse death rate affect result of the test
Note: compare * * P < 0.01 with model control group
Result shows, and invention formulation group compares with model control group, and mouse death rate obviously reduces, and dosage is higher, and mortality rate less (P < 0.01), as can be seen here, invention formulation has antiviral effect.
Embodiment 6:
Human feeding trial:
Use the oral liquid of the present invention of preparation in embodiment 1, the raising immunity of organisms effect of this preparation is tested.
Study subject standard: the crowd of simple hypoimmunity, the age between 20 ~ 65 years old, experimental design and grouping: adopt two kinds of control design between self and group.By the routine experimenter of above-mentioned Standard Selection 100, requirement according to randomized, double-blind is divided into groups, be divided into test-meal group and matched group, consider the principal element affecting result as far as possible, as the age, sex, diet etc., carry out harmony verification, with the comparability between guarantee group, often organize experimenter 50 example, test-meal group takes oral liquid of the present invention 2 times for each person every day, a 10mL, matched group takes placebo, take 60d continuously, grouping situation is in table 3, two groups of hematurias just conventional and hepatic and renal function before test-meal, breast is saturating, electrocardiogram, B ultrasonic etc. check all within normal range, two groups of subject age sexes, the equal no significant difference of macrophage content (P > 0.05) in lymphocyte in blood and body, there is comparability.
Before table 3 test-meal, physical data compares
After test-meal, situation is in table 4, table 5.
Table 4 blood testing-lymphocyte
Table 5 blood testing-macrophage
From table 4, table 5, take rear 60d, before and after the test-meal of test-meal group, lymphocyte and macrophage content all significantly improve (P < 0.01), and significantly better than matched group, two group differences very significantly (P < 0.01).
Result shows, after examination takes invention formulation 60d, self compare before and after the test-meal of test-meal group and compare between test-meal group with matched group group after test-meal, lymphocytes in blood and macrophage content all significantly improve (P < 0.01), so this invention preparation has the effect of enhancing human body immunity power.
Claims (2)
1. one kind antibacterial, antiviral, regulate metabolism, strengthen the oral liquid of immunity, it adopts Cordyceps militaris (L.) Link. 50 ~ 500 parts, Carrageenan sugar 5 ~ 50 parts, marine fish collagen oligopeptide powder 5 ~ 50 parts, 60 ~ 600 parts, Rhizoma Zingiberis Recens, 300 ~ 1500 parts, Fructus Jujubae, 200 ~ 1000 parts, Radix Glycyrrhizae, the Radix Astragali 200 ~ 1000 parts, Mel 30 ~ 200 parts, citric acid 10 ~ 30 parts, aspartame 5 ~ 10 parts, potassium sorbate 3 ~ 5 parts, 10000 ~ 50000 parts, water is made, its preparation technology is: Cordyceps militaris (L.) Link. was pulverized 80 mesh sieves, enzymatic vessel is put into by formula ratio, add the water of 20 times, add 500,000 U/g cellulase 1.5 ~ 3.0 parts enzymolysis 4h under the condition of 38 ~ 43 DEG C, add Carrageenan sugar, after aspartame mixing, enzyme denaturing 30min under 90 ~ 100 DEG C of conditions, constantly stir simultaneously, by Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Glycyrrhizae, the Radix Astragali 6 ~ 8 times of water extraction 90 minutes, filter, enzymolysis solution is mixed with Chinese medicine extraction liquid, adds marine fish collagen oligopeptide powder, Mel, citric acid, potassium sorbate, be warming up to 60 DEG C, stir simultaneously constantly and make it mix homogeneously, then through 0.22 μm of membrane filtration, fill and get final product.
2. a kind of antibacterial, antiviral according to claim 1, adjustment metabolism, strengthen the oral liquid of immunity, it is characterized in that caning be passed through fill makes oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510062479.6A CN104606659A (en) | 2015-02-02 | 2015-02-02 | Antimicrobial and antiviral oral liquid for regulating metabolism and enhancing immunity |
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| CN201510062479.6A CN104606659A (en) | 2015-02-02 | 2015-02-02 | Antimicrobial and antiviral oral liquid for regulating metabolism and enhancing immunity |
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| CN104606659A true CN104606659A (en) | 2015-05-13 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105901731A (en) * | 2016-04-26 | 2016-08-31 | 铜陵市佘家贡姜厂 | Antibacterial and antiviral ginger pills and preparation method thereof |
| CN106690121A (en) * | 2016-11-14 | 2017-05-24 | 威海力元海洋生物科技有限公司 | Trepang, hippophae rhamnoides fruit, cordyceps militaris and selenium preparation and preparation technology thereof |
| CN110327246A (en) * | 2019-08-12 | 2019-10-15 | 青岛博智汇力生物科技有限公司 | A kind of mouthwash containing marine oligosaccharide |
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| CN1085433A (en) * | 1993-07-03 | 1994-04-20 | 沈阳市好猫生物技术研究所 | Caoling nutrient solution and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1085433A (en) * | 1993-07-03 | 1994-04-20 | 沈阳市好猫生物技术研究所 | Caoling nutrient solution and preparation method thereof |
Non-Patent Citations (2)
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| PXLZBP133: "蛹虫草课件", 《百度文库》 * |
| 汪振炯等: "微波协同酶法提取蛹虫草基质多糖工艺的优化研究", 《食品工业科技》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105901731A (en) * | 2016-04-26 | 2016-08-31 | 铜陵市佘家贡姜厂 | Antibacterial and antiviral ginger pills and preparation method thereof |
| CN106690121A (en) * | 2016-11-14 | 2017-05-24 | 威海力元海洋生物科技有限公司 | Trepang, hippophae rhamnoides fruit, cordyceps militaris and selenium preparation and preparation technology thereof |
| CN110327246A (en) * | 2019-08-12 | 2019-10-15 | 青岛博智汇力生物科技有限公司 | A kind of mouthwash containing marine oligosaccharide |
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