CN106690121A - Trepang, hippophae rhamnoides fruit, cordyceps militaris and selenium preparation and preparation technology thereof - Google Patents
Trepang, hippophae rhamnoides fruit, cordyceps militaris and selenium preparation and preparation technology thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to the technical field of traditional Chinese medicine health-care products, in particular to a trepang, hippophae rhamnoides fruit, cordyceps militaris and selenium preparation and a preparation technology thereof. The preparation is characterized by consisting of the following components in parts by weight of 20-30 parts of trepang powder, 10-25 parts of pseudo-ginseng, 25-60 parts of hippophae rhamnoides fruit powder, 20-30 parts of radix astragali, 10-25 parts of dendrobium nobile stem powder, 10-20 parts of cordyceps militaris, 5-15 parts of chitosan oligosaccharide, 10-18 parts of glucan, 10-22 parts of paecilomyces hepiali powder, 15-30 parts of a ginger extract and 0.01-0.05 part of selenium. The trepang, hippophae rhamnoides fruit, cordyceps militaris and selenium preparation has the advantages of improving the immunity of human bodies, promoting blood circulation, supplementing qi, strengthening constitutions of human bodies, resisting radiation, delaying aging, improving memory and the like.
Description
Technical field
The present invention relates to traditional Chinese medicine health care product technical field, specifically a kind of enhancing body immunity, promoting blood circulation, tonifying Qi increase
Strong human body constitution, radioresistance, anti-aging, the sea cucumber sea-buckthorn Chinese caterpillar fungus selenium preparation of raising memory and its preparation technology.
Background technology
With the development of social economy, the growth in the living standard of people, people are more next to the attention degree of own health
It is bigger, but, due to the quickening of work rhythm, the reduction of the increase of job and life stress, and motion, the immunity of people is general
All over low.One kind reaction that body immunity refers to body to alien material, is the material of body identification " oneself " and " non-".
" non-" is excluded or removed.It is human bioequivalence and eliminates any material of external intrusion, treatment aging, damages, extremely
The ability of the own cells die, being denatured and identification and treatment vivo mutations cell and virus infected cell, hypoimmunity
Body is easy to infected or cancer stricken, and immunity overlength also can produce infringement, such as allergic reaction, autoimmunity disease to body,
Because a variety of causes prevents immune system from normally playing protective effect, in the case, easily cause bacterium, virus, fungi, etc.
Infection, or cross the attack of polyradical.Therefore most directly showing for hypoimmunity is exactly liable to illness, with the age
Increase, failure of memory also can cause very big inconvenience to life..
The content of the invention
Present invention aim to address above-mentioned the deficiencies in the prior art, there is provided one kind enhancing body immunity, promoting blood circulation, tonifying Qi
Enhancing human body constitution, radioresistance, anti-aging, the sea cucumber sea-buckthorn Chinese caterpillar fungus selenium preparation of raising memory and its preparation technology.
The technical solution adopted for the present invention to solve the technical problems is：
A kind of sea cucumber sea-buckthorn Chinese caterpillar fungus selenium preparation, it is characterised in that the constituent of said preparation is sea cucumber powder, pseudo-ginseng, seabuckthorn fruit powder, Huang
Stilbene, dendrobe powder, Cordyceps militaris, chitosan oligosaccharide, glucan, peacilomyce hepiahi bacterium silk powder, ginger extract, selenium element composition, it is above-mentioned each
The weight portion of individual composition is：20-30 parts of sea cucumber powder, pseudo-ginseng 10-25 parts, 25-60 parts of seabuckthorn fruit powder, 20-30 parts of the Radix Astragali, the stem of noble dendrobium
10-25 parts of powder, 10-20 parts of Cordyceps militaris, 5-15 parts of chitosan oligosaccharide, 10-18 parts of glucan, peacilomyce hepiahi bacterium silk powder 10-
22 parts, 15-30 parts of ginger extract, 0.01-0.05 part of selenium element.
The optimization weight portion of each composition of invention formulation is：25-30 parts of sea cucumber powder, pseudo-ginseng 15-23 parts, sea-buckthorn
44-50 parts of powder, 25-30 parts of the Radix Astragali, 10-15 parts of dendrobe powder, 10-15 parts of Cordyceps militaris, 8-12 parts of chitosan oligosaccharide, glucan
10-12 parts, 17-22 parts of peacilomyce hepiahi bacterium silk powder, 22-30 parts of ginger extract, 0.01-0.05 part of selenium element.
A kind of preparation technology of sea cucumber sea-buckthorn Chinese caterpillar fungus selenium preparation, it is characterised in that step of preparation process is as follows：
（1）Sea cucumber powder：New fresh sea cucumber is cleaned first, is cut off, removing internal organ, the enzyme containing sea cucumber self-dissolving that reservation is flowed out
Liquid, and the impurity in the sea cucumber intestine and sea cucumber in sea cucumber internal organ is cleared, and sea cucumber intestine and sea cucumber are standby in the lump, then will
Ball milling is beaten after sea cucumber, sea cucumber intestine and sea cucumber are crushed, and adds in enzymatic vessel, adds 5 ~ 10 times of sea cucumber raw material of water, then
The liquid and appropriate food flavor enzyme of the enzyme containing sea cucumber self-dissolving for retaining are added, is well mixed, open steam cock, be warming up to gradually
45 ~ 65 DEG C, under conditions of being stirred continuously, constant temperature 3.5 ~ 4 hours is maintained, treat that whole liquid is clarified substantially and be warming up to 100 DEG C, 5 ~
After 10 minutes, gained supernatant liquid adjustment concentration is 2% ~ 10% by cooling filtering, and it is dry then to carry out spraying with clean spray drying tower
Dry, after the assay was approved, polybag vacuumizes packaging to the spray powder of gained, and Cord blood is standby.
(2) Radix Notoginseng powder：The pseudo-ginseng of the qualified unit purchase of qualification is taken, according to Chinese Pharmacopoeia（Version in 2015）Standard, through chemical examination
It is qualified, broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls at 40 degree, ORW105 microwave vacuums are done
Dry machine is pulverized and sieved to 200 mesh with the qualified stainless steel pulverizer for the treatment of again after drying, and is packaged spare.
（3）Seabuckthorn fruit powder：Will in the seabuckthorn fruit powder of qualification qualified unit purchase, and unit of selling goods laboratory test report, send inspection center
It is qualified to recheck, and is added water with JYL-5 wall-breaking machines and carry out broken wall treatment in right amount, with pressure 0.09MP temperature controls in 40 degree, ORW105
After microwave vacuum dryer is dried, crushed in being crushed with clean stainless steel pulverizer, 200 eye mesh screens are then crossed, by institute
Obtain standby after powder-tight is packed；
（4）The Radix Astragali：The Radix Astragali of qualified qualification unit purchase is taken, together with the laboratory test report of unit of selling goods, according to according to Chinese Pharmacopoeia
（Version one in 2015）Standard, it is qualified by checking, broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls
System after ORW105 microwave vacuum dryers are dried, is crushed, then mistake at 40 degree in being crushed with clean stainless steel pulverizer
200 eye mesh screens, it is standby after gained powder-tight is packed；
（5）The stem of noble dendrobium：The raw material of the qualified unit purchase of qualification is taken, according to Chinese Pharmacopoeia（Version one in 2015）Standard, closes through chemical examination
Lattice, broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls in 40 degree, ORW105 microwave vacuum dryers
After drying, pulverized and sieved to 200 mesh with the stainless steel pulverizer for processing qualified, packaged spare.
（6）Cordyceps militaris：The raw material of the qualified unit purchase of selection qualification, it is qualified through chemically examining according to standard, use JYL-5 broken walls
Machine carries out broken wall treatment, with pressure 0.09MP temperature controls at 40 degree, after ORW105 microwave vacuum dryers are dried, is closed with treatment
The stainless steel pulverizer of lattice pulverizes and sieves to 200 mesh, packages spare
（7）Chitosan oligosaccharide：The raw material of the qualified unit purchase of selection qualification, it is qualified through chemically examining according to standard, entered with JYL-5 wall-breaking machines
Row broken wall treatment is after ORW105 microwave vacuum dryers are dried then qualified with processing with pressure 0.09MP temperature controls at 40 degree
Stainless steel pulverizer pulverize and sieve to 200 mesh, package spare
（8）Glucan：The raw material of the qualified unit purchase of qualification is taken, it is qualified through chemically examining according to standard, carried out with JYL-5 wall-breaking machines
Broken wall treatment, with pressure 0.09MP temperature controls at 40 degree, after ORW105 microwave vacuum dryers are dried, reprocessing is qualified not
Rust steel pulverizer pulverizes and sieves to 200 mesh, packages spare
（9）Peacilomyce hepiahi bacterium silk powder：The raw material of the qualified unit purchase of selection qualification, it is qualified through chemically examining according to standard, use
JYL-5 wall-breaking machines carry out broken wall treatment, and with pressure 0.09MP temperature controls at 40 degree, ORW105 microwave vacuum dryers are dried
Afterwards, reprocess qualified stainless steel pulverizer to pulverize and sieve to 200 mesh, package spare
（10）Ginger：The raw material of the qualified unit purchase of selection qualification, according to Chinese Pharmacopoeia（Version in 2015）Standard, it is qualified through chemically examining,
Broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls at 40 degree, ORW105 microwave vacuum dryers are dried
Afterwards, reprocess qualified stainless steel pulverizer to pulverize and sieve to 200 mesh, package spare
（11）Selenium element：Selenide of carragheen：Qualified qualification unit purchase selenide of carragheen is selected, send inspection center to check, selenic acid
Polysaccharide ester content >=2.0%, moisture≤6% qualified, then by selenide of carragheen be put into cleaning stainless steel pulverizer in carry out
Crush, then cross 100 eye mesh screens, it is standby after gained powder-tight is packed；
（12）：Qualified sea cucumber powder, pseudo-ginseng, seabuckthorn fruit powder, the Radix Astragali, dendrobe powder, Cordyceps militaris, chitosan oligosaccharide, glucan, bat will be checked
Moth paecilomycerol silk powder, ginger extract, selenium element are placed in mixing 20 minutes of being started shooting in three-dimensional mixer, are well mixed；
（13）：Pelletized according to granulating process,：Uniform raw material mixed above is done into moistening dosage with 65--70% ethanol to pelletize,
It is dried at a temperature of 85--90 degree, whole grain is then carried out according to particle situation.
（14）Filling is encapsulated：In GMP workshops, automatic capsule machine is used, adjusted according to production requirement according to technique start
After examination is qualified, start shooting encapsulated.The qualified product of loading amount is polished in sanding machine, after big packaging, conjunction to be tested between keeping in is moved
Lattice,
（15）Packaging：Capsule will be installed and check qualified again, and send make-up room to be packed, packing instructions will according to technological order
Ask and packed, inner packing is completed in clean area, external packing is completed in normal areas.
（16）Finished product：Through checking qualified packaged capsule, enter the qualified area of warehouse for finished product..
（17）After whole grain of the present invention according to the technological process of production and production ordering be made granule, soft capsule and
Chewable tablets, tablets and other formulations product.
The present invention is gathered due to said preparation by sea cucumber powder, pseudo-ginseng, seabuckthorn fruit powder, the Radix Astragali, dendrobe powder, Cordyceps militaris, chitosan oligosaccharide, Portugal
Sugar, peacilomyce hepiahi bacterium silk powder, ginger extract, selenium element composition, with enhancing body immunity, promoting blood circulation, tonifying Qi enhancing people
The advantages of body constitution, radioresistance, anti-aging, raising memory.
Specific embodiment
A kind of sea cucumber sea-buckthorn Chinese caterpillar fungus selenium preparation, it is characterised in that the constituent of said preparation is sea cucumber powder, pseudo-ginseng, sea-buckthorn
Powder, the Radix Astragali, dendrobe powder, Cordyceps militaris, chitosan oligosaccharide, glucan, peacilomyce hepiahi bacterium silk powder, ginger extract, selenium element composition, on
The weight portion for stating each composition is：20-30 parts of sea cucumber powder, pseudo-ginseng 10-25 parts, 25-60 parts of seabuckthorn fruit powder, 20-30 parts of the Radix Astragali,
10-25 parts of dendrobe powder, 10-20 parts of Cordyceps militaris, 5-15 parts of chitosan oligosaccharide, 10-18 parts of glucan, peacilomyce hepiahi bacterium silk powder
10-22 parts, 15-30 parts of ginger extract, 0.01-0.05 part of selenium element.
The optimization weight portion of each composition of invention formulation is：25-30 parts of sea cucumber powder, pseudo-ginseng 15-23 parts, sea-buckthorn
44-50 parts of powder, 25-30 parts of the Radix Astragali, 10-15 parts of dendrobe powder, 10-15 parts of Cordyceps militaris, 8-12 parts of chitosan oligosaccharide, glucan
10-12 parts, 17-22 parts of peacilomyce hepiahi bacterium silk powder, 22-30 parts of ginger extract, 0.01-0.05 part of selenium element.
A kind of preparation technology of sea cucumber sea-buckthorn Chinese caterpillar fungus selenium preparation, it is characterised in that step of preparation process is as follows：（1）Sea cucumber
Powder：New fresh sea cucumber is cleaned first, is cut off, removing internal organ, the liquid of the enzyme containing sea cucumber self-dissolving that reservation is flowed out, and by sea
The impurity in sea cucumber intestine and sea cucumber in ginseng internal organ is cleared, and sea cucumber intestine and sea cucumber are standby in the lump, then by sea cucumber, sea cucumber intestine
Ball milling mashing after being crushed with sea cucumber, adds in enzymatic vessel, adds 5 ~ 10 times of sea cucumber raw material of water, adds containing for reservation
There are the liquid and appropriate food flavor enzyme of the enzyme of sea cucumber self-dissolving, be well mixed, open steam cock, 45 ~ 65 DEG C are warming up to gradually, not
Under conditions of disconnected stirring, constant temperature is maintained 3.5 ~ 4 hours, treat that whole liquid is clarified substantially and be warming up to 100 DEG C, after 5 ~ 10 minutes, drop
Temperature filtering, is 2% ~ 10% by gained supernatant liquid adjustment concentration, is then spray-dried with clean spray drying tower, the spray of gained
After the assay was approved, polybag vacuumizes packaging to dry powder, and Cord blood is standby；(2) Radix Notoginseng powder：Take the qualified unit purchase of qualification
Pseudo-ginseng, according to Chinese Pharmacopoeia（Version in 2015）Standard, it is qualified through chemically examining, broken wall treatment is carried out with JYL-5 wall-breaking machines, use pressure
0.09MP temperature controls at 40 degree, with the qualified stainless steel pulverizer for the treatment of crushed again after drying by ORW105 microwave vacuum dryers
200 mesh are screened to, are packaged spare；（3）Seabuckthorn fruit powder：Will in the seabuckthorn fruit powder of qualification qualified unit purchase, and unit of selling goods chemical examination
It is single, send inspection center to recheck qualified, added water with JYL-5 wall-breaking machines and carry out broken wall treatment in right amount, with pressure 0.09MP temperature controls
At 40 degree, after ORW105 microwave vacuum dryers are dried, crushed in being crushed with clean stainless steel pulverizer, then mistake
200 eye mesh screens, it is standby after gained powder-tight is packed；（4）The Radix Astragali：The Radix Astragali of qualified qualification unit purchase is taken, together with selling goods
The laboratory test report of unit, according to Chinese Pharmacopoeia（Version one in 2015）Standard, it is qualified by checking, broken with JYL-5 wall-breaking machines
Wall treatment, with pressure 0.09MP temperature controls at 40 degree, after ORW105 microwave vacuum dryers are dried, with clean stainless steel powder
Broken machine is crushed in crushing, and then crosses 200 eye mesh screens, standby after gained powder-tight is packed；（5）The stem of noble dendrobium：Take qualification conjunction
The raw material of lattice unit purchase, according to Chinese Pharmacopoeia（Version one in 2015）Standard, it is qualified through chemically examining, carried out with JYL-5 wall-breaking machines
Broken wall treatment is qualified not with treatment after ORW105 microwave vacuum dryers are dried with pressure 0.09MP temperature controls at 40 degree
Rust steel pulverizer pulverizes and sieves to 200 mesh, packages spare；（6）Cordyceps militaris：The raw material of the qualified unit purchase of selection qualification, according to
Standard, it is qualified through chemically examining, broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls at 40 degree, ORW105 is micro-
After ripple vacuum drier is dried, pulverized and sieved to 200 mesh with the stainless steel pulverizer for processing qualified, packaged spare；（7）Shell is few
Sugar：The raw material of the qualified unit purchase of selection qualification, it is qualified through chemically examining according to standard, broken wall treatment is carried out with JYL-5 wall-breaking machines,
With pressure 0.09MP temperature controls at 40 degree, after ORW105 microwave vacuum dryers are dried, then with the qualified stainless steel powder for the treatment of
Broken machine pulverizes and sieves to 200 mesh, packages spare；（8）Glucan：The raw material of the qualified unit purchase of qualification is taken, according to standard, through changing
Test qualified, broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls at 40 degree, ORW105 microwave vacuums are done
After dry machine is dried, reprocess qualified stainless steel pulverizer and pulverize and sieve to 200 mesh, package spare；（9）Peacilomyce hepiahi bacterium
Silk powder：The raw material of the qualified unit purchase of selection qualification, it is qualified through chemically examining according to standard, carried out at broken wall with JYL-5 wall-breaking machines
Reason, with pressure 0.09MP temperature controls at 40 degree, after ORW105 microwave vacuum dryers are dried, reprocesses qualified stainless steel powder
Broken machine pulverizes and sieves to 200 mesh, packages spare；（10）Ginger：The raw material of the qualified unit purchase of selection qualification, according to Chinese Pharmacopoeia
（Version in 2015）Standard, it is qualified through chemically examining, broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls 40
Degree, after ORW105 microwave vacuum dryers are dried, reprocesses qualified stainless steel pulverizer and pulverizes and sieves to 200 mesh, packs standby
With；（11）Selenium element：Selenide of carragheen：Qualified qualification unit purchase selenide of carragheen is selected, send inspection center to check, selenic acid ester
Polyoses content >=2.0%, moisture≤6% qualified, then by selenide of carragheen be put into cleaning stainless steel pulverizer in carry out powder
It is broken, 100 eye mesh screens are then crossed, it is standby after gained powder-tight is packed；（12）：Qualified sea cucumber powder, pseudo-ginseng, sea-buckthorn will be checked
Powder, the Radix Astragali, dendrobe powder, Cordyceps militaris, chitosan oligosaccharide, glucan, peacilomyce hepiahi bacterium silk powder, ginger extract, selenium element are placed in three
Started shooting in dimension mixer and mixed 20 minutes, be well mixed；（13）：Pelletized according to granulating process,：By uniform raw material mixed above
Moistening dosage is done with 65--70% ethanol to pelletize, be dried at a temperature of 85--90 degree, then carried out according to particle situation whole
Grain；（14）Filling is encapsulated：In GMP workshops, automatic capsule machine is used, carry out debugging qualified according to production requirement according to technique start
Afterwards, start shooting encapsulated.The qualified product of loading amount is polished in sanding machine, after big packaging, moves to be tested qualified between keeping in；（15）
Packaging：Capsule will be installed and check qualified again, and send make-up room to be packed, packing instructions will be wrapped according to technological order requirement
Dress, inner packing is completed in clean area, and external packing is completed in normal areas；（16）Finished product：Through checking qualified bag
The capsule for installing, enters the qualified area of warehouse for finished product；（17）According to the technological process of production and production ordering after whole grain of the present invention
It is made granule, soft capsule and chewable tablets, tablets and other formulations product.
Constituent analysis in the present invention
Sea cucumber powder：Sea cucumber, sweet-salty, kidney tonifying, benefiting quintessence takes the photograph urine, and impotence, its benefit warm in nature, sufficient enemy's ginseng, therefore named sea are treated in establishing-Yang
Ginseng；Sea cucumber have improve memory, delay sexual gland aging, prevent artery sclerosis and it is antitumor wait act on.
Pseudo-ginseng：Return liver, stomach；Effect：Dissipate stasis of blood hemostasis, detumescence ding-tong；Cure mainly：For spitting blood, spit blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, collapsed
Leakage, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
Seabuckthorn fruit powder：Effect has preventing and treating cardiovascular and cerebrovascular disease：Total seabuckthorn flavone, unrighted acid extracted from sea-buckthorn etc.
Composition can effectively adjust blood pressure, blood fat, blood sugar, directly remove superoxide radical and hydroxy radical, reduce blood viscosity, suppress blood
Platelet is excessively assembled, softening blood vessel, improve blood circulation, prevent artery sclerosis, to coronary heart diseases and angina pectoris, miocardial infarction, the rhythm of the heart
The illnesss such as not normal, myocardial ischemia-anoxemia have fabulous preventive and therapeutic effect, in addition to improving heart function, alleviating uncomfortable in chest, palpitaition, shortness of breath etc.
Symptom also plays the role of fabulous；Auxiliary treatment diabetes, the active ingredient extracted from sea-buckthorn（Hippophate flavone, vitamin, mineral
Matter, trace element, SOD etc.）Blood sugar, the state of an illness of stabilization diabetes can be reduced；Enhancing immune function of human body, containing a large amount of in sea-buckthorn
Vitamin C, vitamin E, carotenoid, SOD, Hippophate flavone all have very strong antioxidation.To humoral immunity and carefully
Born of the same parents are immune to have obvious adjustment effect, also certain anti-allergic effects, enhancing human disease resistance, these active ingredient energy
Human free radical is removed, body's immunity effect is improved, thus clinic is to panimmunity systemic disease such as immunologic hypofunction
Acted on very well etc. having.The other adjustable thyroid function in Hippophate flavone sea, makes hyperthyroidism recover normal；Antitumor,
Antitumaous effect；The white anthocyanidin of bioactive ingredients, guassin, cumarin, serotonin, bata-carotene in sea-buckthorn etc. have bright
Aobvious antioxidant effect.There is certain suppression and lethal effect to the cancer cell in human body, also with the work of blocking carcinogenic factor
With.And can by improving the autoimmune function of cancer patient, enhancing human body to the resistivity of cancer, especially to stomach
The cancer effect of the digestive systems such as cancer, cancer of the esophagus, the carcinoma of the rectum, liver cancer is quite obvious.The poison that radiotherapy and chemotherapy can be mitigated in addition is secondary
Effect, promotes cancer patient's rehabilitation；Anti- treating respiratory system disease, sea-buckthorn just has relieving cough and asthma, profit in traditional medical theory
The effect of lung resolving sputum, has very to respiratory tract system diseases such as chronic pharyngitis, bronchitis, abscess of throat, asthma, cough ant phlegms
Good effect；Liver protecting, prevents and treats liver diseases, the organic acid such as the malic acid contained in sea-buckthorn, oxalic acid have alleviate antibiotic and
The toxic action of other drugs, promotes impaired stem cell to accelerate healing, reduces transaminase, protects liver.Simultaneously to liver pair
In fat there is elimination to act on.There is obvious mitigation to acute liver disease, chronic liver disease, alcoholic liver, fatty liver, cirrhosis.
In addition, Seabuckthorn Oil has significant protective effect to kidney and marrow；Disease of digestive system is prevented and treated, it is big due to containing in sea-buckthorn
The multiple nutritional components such as amount amino acid, organic acid, can promote hydrochloric acid in gastric juice, gastric secretion thus sea-buckthorn has relieving dyspepsia, invigorating the spleen
Nourishing the stomach, the effect of dispersing stagnated hepatoqi.For indigestion, abdominal distention and pain, gastritis, gastric and duodenal ulcer, enteritis, chronic constipation etc.
Play the role of fabulous；Ophthalmology disease is prevented and treated, is contained in sea-buckthorn and is whether there is hydroxytryptamine with very strong radiation resistance.The former Soviet Union is husky
Spine oil lists the necessary health products of astronaut in.There is remarkable result to preventing and treating all kinds of ophthalmology diseases.Trachoma, eyeball can be treated with it
Flajani's disease, keratitis, bubble, eyelid burn and conjunctivitis etc.；Hemostatic analgesia, anti-inflammation detumescence, removing necrosis, promoting granulation treatment
Various gynecological diseases, the Seabuckthorn Oil extracted in sea-buckthorn is rich in VE, carrotene, carotenoid, cupreol, unrighted acid
Deng, body metabolism can be promoted, be conducive to the organized renewing for damaging, strengthen the antiinflammatory action at inflammation center, and significantly
Promote ulcer healing effect.Thus Seabuckthorn Oil clinically to radiation injury, burn, scald, dermatitis, catarrh, canker sore,
Endometritis, cervical erosion and stomach and pain, reduction adverse reaction, also there is effect very well；It is brain tonic and intelligence development, beauty and skin care, anti-ageing
Always, several amino acids, multivitamin, trace element, unrighted acid, SOD for containing in sea-buckthorn etc. are old to preventing skin
Change, desalination senile plaque expelling, chloasma, improve the health care of sleep quality, improve memory, keep vigorous energy and the muscle power to have good work
With.
The Radix Astragali：Nature and flavor：It is sweet, tepor；Return through：Return lung, spleen, liver and kidney channel；It has enhancing body's immunity, liver protection, profit
Urine, anti-aging, resisting stress, step-down and wide antibacterial action.But table is real evil to be contained, and retention of dampness due to stagnation of QI, dyspepsia is stagnated, ulcer from the beginning of
Or heat toxin such as still contains at the real example after bursting.
Dendrobe powder：Property slightly sweet flavor it is micro- salty, tremble with fear, return stomach, kidney, lung channel.Reinforcing stomach reg fluid, nourishing Yin and clearing heat.For impairment of yin body fluid deficiency, mouth
Dry polydipsia, deficiency of food is retched, after being ill abnormal heat, and mesh is secretly failed to understand.
Cordyceps militaris：Cordycepic acid (mannitol) enters lung kidney two warp, can tonifying lung it is cloudy, and can kidney-replenishing, cure mainly kidney deficiency, impotence is lost
Essence, soreness of waist and knee joint, eak after being ill, chronic cough is weak, phthisical cough phlegm blood, and spontaneous sweating etc., is that unique one kind can be while balancing, adjusting
The Chinese medicine of negative and positive.
Chitosan oligosaccharide：It is made up of shitosan depolymerization, is chitin, the upgrading products of shitosan product, with shitosan not
The advantages such as analogous superiority, molecular weight is low, good water solubility, function is big, be easily absorbed by the body, bioactivity is high.Together
When have：Pure natural, radiationless, pollution-free, no added the features such as, immunological regulation, antitumor, reducing blood lipid to human body, regulation
Blood sugar, improvement liver and cardio-pulmonary function and other different physiological roles important roles.
Glucan：Improve the ability of the infection such as body resistance virus, bacterium；The Tiny ecosystem of effective adjusting body digested road,
Promote the excretion of nuisance in the propagation and enteron aisle of internal beneficial bacterium；Internal cholesterol level can be reduced, it is possible to decrease low close in vivo
Degree lipoprotein content, and increase the content of HDL；Impression of the distal tissues to insulin is effectively improved, is reduced to pancreas
The requirement of island element, promotes glucose to recover normal, there is obvious suppression and prevention effect to diabetes；Skin Cell is stimulated to live
Property, strengthening the immunity protection function of skin itself, efficient repairing sheath skin reduces wrinkle of skin generation, delay skin aging；Enhancing
Animal promotes it to grow the resistivity of germ, improves the production performance and efficiency of feed utilization of animal.
Peacilomyce hepiahi bacterium silk powder：Cordyceps sinensis（Synonym has：China is by hair spore, Paecilomyces hepiali chen and bat
Moth is by hair spore）, Chinese nickname is also known as Chinese caterpillar fungus, CORDYCEPS, Cordyceps sinensis（cordyceps sinensis）It is a kind of extremely rare
Chinese medicinal herbs and senior tonic.Chinese caterpillar fungus is larva and the combination of fungi of a kind of insect, and winter worm is the children of Hepialus
Worm, summer grass is a kind of aweto fungus, is mainly grown in the severe cold areas of height above sea level 3000-4000m, is distributed in Sichuan, Yunnan, expensive
The ground such as state, Gansu, Tibet and Qinghai.It is divided into the world and is furnished with 350 kinds of Chinese caterpillar funguses, China there are more than 60 kinds.It is main with cordyceps
The curative and health food of development of raw materials are increasingly favored.Other raw materials and nutrition are added, through modern science and technology
The caterpillar fungus cephalosporin powder product series of processing and refining, with building up health, anti-aging, cardioprotection, improve the health care of sleep, increase
Plus the effect of appetite, raising immune function of human body.
Ginger extract：Taste is pungent；It is warm in nature；Return lung, stomach, the spleen channel；Indication：Relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, warm lung cough-relieving.
It is usually used in deficiency-cold in spleen and stomach, anorexia, n and V, or phlematic vomiting, the vomiting of disorder of stomach-energy, chill or cold productive cough are coughed, feels
Emit chill, fever with aversion to wind, nasal obstruction headache.It can also solve the drug poisoning such as dried pinellia, arisacma consanguineum schott, and the food poisoning such as ichthyophagy crab.
Selenium element：The universal immunologic hypofunction of hepatopath, its most obvious performance is exactly that internal virus is difficult to completely
Remove, the easy recurrent exerbation of the state of an illness.And the main component selenide of carragheen of liver gold is potent immunosuppressant conditioning agent, body fluid can be stimulated
Immune system, strengthens the immunologic function of body, the resistance against diseases of liver itself is improved, so as to help to prevent the anti-of liver disease
Recurrence is made.In addition, the enhancing of immunologic function, is conducive to improving the various symptoms of hepatopath, such as hepatitis A, B patient selenium-supply
Changing carragheen can substantially improve the symptoms such as anorexia, weak, face be dark and gloomy within the relatively short time.
Embodiment 1
22 parts of sea cucumber powder, 14 parts of pseudo-ginseng, 30 parts of seabuckthorn fruit powder, 21 parts of the Radix Astragali, 14 parts of dendrobe powder, 12 parts of Cordyceps militaris, 8 parts of chitosan oligosaccharide,
13 parts of glucan, 14 parts of peacilomyce hepiahi bacterium silk powder, 16 parts of ginger extract, 0.01 part of selenium element.
Embodiment 2
28 parts of sea cucumber powder, 24 parts of pseudo-ginseng, 55 parts of seabuckthorn fruit powder, 28 parts of the Radix Astragali, 21 parts of dendrobe powder, 18 parts of Cordyceps militaris, 12 parts of chitosan oligosaccharide,
14 parts of glucan, 20 parts of peacilomyce hepiahi bacterium silk powder, 28 parts of ginger extract, 0.05 part of selenium element.
Embodiment 3
25 parts of sea cucumber powder, 20 parts of pseudo-ginseng, 44 parts of seabuckthorn fruit powder, 26 parts of the Radix Astragali, 19 parts of dendrobe powder, 18 parts of Cordyceps militaris, 12 parts of chitosan oligosaccharide,
13 parts of glucan, 17 parts of peacilomyce hepiahi bacterium silk powder, 22 parts of ginger extract, 0.03 part of selenium element.
Embodiment 4
21 parts of sea cucumber powder, 13 parts of pseudo-ginseng, 27 parts of seabuckthorn fruit powder, 24 parts of the Radix Astragali, 17 parts of dendrobe powder, 18 parts of Cordyceps militaris, 14 parts of chitosan oligosaccharide,
13 parts of glucan, 17 parts of peacilomyce hepiahi bacterium silk powder, 24 parts of ginger extract, 0.02 part of selenium element.
Embodiment 5
27 parts of sea cucumber powder, 19 parts of pseudo-ginseng, 54 parts of seabuckthorn fruit powder, 22 parts of the Radix Astragali, 17 parts of dendrobe powder, 13 parts of Cordyceps militaris, 12 parts of chitosan oligosaccharide,
11 parts of glucan, 14 parts of peacilomyce hepiahi bacterium silk powder, 27 parts of ginger extract, 0.02 part of selenium element.
Crowd's test-meal result
1. 100 patients are tracked, this 100 patients, immunity is low, usually once restoring a reactionary rule, be easy for generation and catch a cold and adjoint
Fever, and resistance is substantially low, takes this product three months or so, and resistance is significantly improved, and treats bad weather change
Change is not easy to catch a cold, wherein, without flu, 15 patient's times of common cold are significantly reduced for 80 patient's wintry weather changes,
The flu healing cycle substantially reduces, 5 patient's times of common cold reductions, cures by typically taking medicine.
2. text certain, people from Shandong, female, 60 years old, frequent flu, light then inaccessible runny nose, headache was uncomfortable, aversion to cold heavy then afraid of the wind, often
Change flu 5-6 times in year, be required for having an injection every time taking medicine, also need to have an intravenous drip in hospital when serious, could fully recover within general 15 days or so,
After taking product of the invention, flu is changed per annual 1-2 times, resistance is significantly improved.
3. Chen, people from Shandong, female, 55 years old, tired think of felt that insobriety is clear, and decrease of memory is it is obvious that sleep every night
Sleep not enough, each two hour is waken up once, and sleep quality is poor, after taking this patent product half a year, feel that thinking is more flexible, it is also pungent
Duty is pondered a problem, and memory is significantly improved, and memory thing is clearly orderly.
4. Lee, female, 65, blood stasis deficiency of blood complexion committee is yellow, and void is not mended, and malaise takes invention formulation three months
Afterwards, have rosy cheeks, complexion is obviously improved, muscle power foot is in a cheerful frame of mind.
The present invention is gathered due to said preparation by sea cucumber powder, pseudo-ginseng, seabuckthorn fruit powder, the Radix Astragali, dendrobe powder, Cordyceps militaris, chitosan oligosaccharide, Portugal
Sugar, peacilomyce hepiahi bacterium silk powder, ginger extract, selenium element composition, with enhancing body immunity, promoting blood circulation, tonifying Qi enhancing people
The advantages of body constitution, radioresistance, anti-aging, raising memory.
Claims (3)
1. a kind of sea cucumber sea-buckthorn Chinese caterpillar fungus selenium preparation, it is characterised in that the constituent of said preparation be sea cucumber powder, pseudo-ginseng, seabuckthorn fruit powder,
The Radix Astragali, dendrobe powder, Cordyceps militaris, chitosan oligosaccharide, glucan, peacilomyce hepiahi bacterium silk powder, ginger extract, selenium element composition, it is above-mentioned
The weight portion of each composition is：20-30 parts of sea cucumber powder, pseudo-ginseng 10-25 parts, 25-60 parts of seabuckthorn fruit powder, 20-30 parts of the Radix Astragali, stone
10-25 parts of dry measure used in former times powder, 10-20 parts of Cordyceps militaris, 5-15 parts of chitosan oligosaccharide, 10-18 parts of glucan, peacilomyce hepiahi bacterium silk powder
10-22 parts, 15-30 parts of ginger extract, 0.01-0.05 part of selenium element.
2. a kind of sea cucumber sea-buckthorn Chinese caterpillar fungus selenium preparation according to claim 1, it is characterised in that described preparation each into
Point optimization weight portion be：25-30 parts of sea cucumber powder, pseudo-ginseng 15-23 parts, 44-50 parts of seabuckthorn fruit powder, 25-30 parts of the Radix Astragali, stone
10-15 parts of dry measure used in former times powder, 10-15 parts of Cordyceps militaris, 8-12 parts of chitosan oligosaccharide, 10-12 parts of glucan, peacilomyce hepiahi bacterium silk powder
17-22 parts, 22-30 parts of ginger extract, 0.01-0.05 part of selenium element.
3. a kind of preparation technology of sea cucumber sea-buckthorn Chinese caterpillar fungus selenium preparation, it is characterised in that step of preparation process is as follows：
（1）Sea cucumber powder：New fresh sea cucumber is cleaned first, is cut off, removing internal organ, the enzyme containing sea cucumber self-dissolving that reservation is flowed out
Liquid, and the impurity in the sea cucumber intestine and sea cucumber in sea cucumber internal organ is cleared, and sea cucumber intestine and sea cucumber are standby in the lump, then will
Ball milling is beaten after sea cucumber, sea cucumber intestine and sea cucumber are crushed, and adds in enzymatic vessel, adds 5 ~ 10 times of sea cucumber raw material of water, then
The liquid and appropriate food flavor enzyme of the enzyme containing sea cucumber self-dissolving for retaining are added, is well mixed, open steam cock, be warming up to gradually
45 ~ 65 DEG C, under conditions of being stirred continuously, constant temperature 3.5 ~ 4 hours is maintained, treat that whole liquid is clarified substantially and be warming up to 100 DEG C, 5 ~
After 10 minutes, gained supernatant liquid adjustment concentration is 2% ~ 10% by cooling filtering, and it is dry then to carry out spraying with clean spray drying tower
Dry, after the assay was approved, polybag vacuumizes packaging to the spray powder of gained, and Cord blood is standby.
(2) Radix Notoginseng powder：The pseudo-ginseng of the qualified unit purchase of qualification is taken, according to Chinese Pharmacopoeia（Version in 2015）Standard, it is qualified through chemically examining,
Broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls at 40 degree, ORW105 microwave vacuum dryers are done
Pulverized and sieved to 200 mesh with the qualified stainless steel pulverizer for the treatment of again after dry, packaged spare.
（3）Seabuckthorn fruit powder：Will in the seabuckthorn fruit powder of qualification qualified unit purchase, and unit of selling goods laboratory test report, send inspection center to recheck
It is qualified, added water with JYL-5 wall-breaking machines and carry out broken wall treatment in right amount, with pressure 0.09MP temperature controls in 40 degree, ORW105 microwaves
After vacuum drier is dried, crushed in being crushed with clean stainless steel pulverizer, 200 eye mesh screens are then crossed, by gained powder
End packs rear standby；
（4）The Radix Astragali：The Radix Astragali of qualified qualification unit purchase is taken, together with the laboratory test report of unit of selling goods, according to according to Chinese Pharmacopoeia
（Version one in 2015）Standard, it is qualified by checking, broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls
System after ORW105 microwave vacuum dryers are dried, is crushed, then mistake at 40 degree in being crushed with clean stainless steel pulverizer
200 eye mesh screens, it is standby after gained powder-tight is packed；
（5）The stem of noble dendrobium：The raw material of the qualified unit purchase of qualification is taken, according to Chinese Pharmacopoeia（Version one in 2015）Standard, closes through chemical examination
Lattice, broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls in 40 degree, ORW105 microwave vacuum dryers
After drying, pulverized and sieved to 200 mesh with the stainless steel pulverizer for processing qualified, packaged spare.
（6）Cordyceps militaris：The raw material of the qualified unit purchase of selection qualification, it is qualified through chemically examining according to standard, entered with JYL-5 wall-breaking machines
Row broken wall treatment is qualified with processing after ORW105 microwave vacuum dryers are dried with pressure 0.09MP temperature controls at 40 degree
Stainless steel pulverizer pulverizes and sieves to 200 mesh, packages spare
（7）Chitosan oligosaccharide：The raw material of the qualified unit purchase of selection qualification, it is qualified through chemically examining according to standard, entered with JYL-5 wall-breaking machines
Row broken wall treatment is after ORW105 microwave vacuum dryers are dried then qualified with processing with pressure 0.09MP temperature controls at 40 degree
Stainless steel pulverizer pulverize and sieve to 200 mesh, package spare
（8）Glucan：The raw material of the qualified unit purchase of qualification is taken, it is qualified through chemically examining according to standard, carried out with JYL-5 wall-breaking machines
Broken wall treatment, with pressure 0.09MP temperature controls at 40 degree, after ORW105 microwave vacuum dryers are dried, reprocessing is qualified not
Rust steel pulverizer pulverizes and sieves to 200 mesh, packages spare
（9）Peacilomyce hepiahi bacterium silk powder：The raw material of the qualified unit purchase of selection qualification, it is qualified through chemically examining according to standard, use
JYL-5 wall-breaking machines carry out broken wall treatment, and with pressure 0.09MP temperature controls at 40 degree, ORW105 microwave vacuum dryers are dried
Afterwards, reprocess qualified stainless steel pulverizer to pulverize and sieve to 200 mesh, package spare
（10）Ginger：The raw material of the qualified unit purchase of selection qualification, according to Chinese Pharmacopoeia（Version in 2015）Standard, it is qualified through chemically examining,
Broken wall treatment is carried out with JYL-5 wall-breaking machines, with pressure 0.09MP temperature controls at 40 degree, ORW105 microwave vacuum dryers are dried
Afterwards, reprocess qualified stainless steel pulverizer to pulverize and sieve to 200 mesh, package spare
（11）Selenium element：Selenide of carragheen：Qualified qualification unit purchase selenide of carragheen is selected, send inspection center to check, selenic acid
Polysaccharide ester content >=2.0%, moisture≤6% qualified, then by selenide of carragheen be put into cleaning stainless steel pulverizer in carry out
Crush, then cross 100 eye mesh screens, it is standby after gained powder-tight is packed；
（12）：Qualified sea cucumber powder, pseudo-ginseng, seabuckthorn fruit powder, the Radix Astragali, dendrobe powder, Cordyceps militaris, chitosan oligosaccharide, glucan, bat will be checked
Moth paecilomycerol silk powder, ginger extract, selenium element are placed in mixing 20 minutes of being started shooting in three-dimensional mixer, are well mixed；
（13）：Pelletized according to granulating process,：Uniform raw material mixed above is done into moistening dosage with 65--70% ethanol to pelletize,
It is dried at a temperature of 85--90 degree, whole grain is then carried out according to particle situation.
（14）Filling is encapsulated：In GMP workshops, automatic capsule machine is used, debugging conjunction is carried out according to production requirement according to technique start
After lattice, start shooting encapsulated.The qualified product of loading amount is polished in sanding machine, after big packaging, moves to be tested qualified between keeping in,
（15）Packaging：Capsule will be installed and check qualified again, and send make-up room to be packed, packing instructions will according to technological order
Ask and packed, inner packing is completed in clean area, external packing is completed in normal areas.
（16）Finished product：Through checking qualified packaged capsule, enter the qualified area of warehouse for finished product..
（17）After whole grain of the present invention granule, soft capsule and chewing are made according to the technological process of production and production ordering
Piece, tablets and other formulations product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108935891A (en) * | 2018-05-09 | 2018-12-07 | 安徽过湾农业科技有限公司 | A kind of production method of the selenium-rich pressed candy with radiation-resisting functional |
| CN112641812A (en) * | 2020-12-30 | 2021-04-13 | 广东粤微食用菌技术有限公司 | Fermented cordyceps composition with immunity enhancing effect and preparation method and application thereof |
| IT202000017914A1 (en) * | 2020-07-23 | 2022-01-23 | Meti Biosolutions S R L | FORMULATION FOR USE IN THE TREATMENT OF SIDE EFFECTS RESULTING FROM RADIOTHERAPY |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1650988A (en) * | 2004-12-13 | 2005-08-10 | 北京阜康仁生物制药科技有限公司 | Chinese medicinal preparation for treating heart brain blood vessel diseases and its preparation method |
| CN101856120A (en) * | 2010-03-23 | 2010-10-13 | 无锡市天赐康生物科技有限公司 | Health food for improving immunity of human body and preparation method thereof |
| CN102579837A (en) * | 2012-03-02 | 2012-07-18 | 安徽圣农生物科技股份有限公司 | Soft dendrobium huoshanense capsule and preparation method thereof |
| CN103211220A (en) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | Health food with function of enhancing immunity and preparation method thereof |
| CN104351612A (en) * | 2014-11-21 | 2015-02-18 | 威海力元海洋生物科技有限公司 | Sea cucumber, lucid ganoderma, glucan and selenium preparation and preparation method thereof |
| CN104489457A (en) * | 2014-11-27 | 2015-04-08 | 扬州日兴生物科技股份有限公司 | Dietary formula containing chitosan oligosaccharide and cordyceps militaris powder for liver cancer patients |
| CN104606659A (en) * | 2015-02-02 | 2015-05-13 | 威海康博尔生物药业有限公司 | Antimicrobial and antiviral oral liquid for regulating metabolism and enhancing immunity |
| CN105079044A (en) * | 2015-09-23 | 2015-11-25 | 李�杰 | Preparation method of soft capsules containing Chinese caterpillar funguses |
| CN105533710A (en) * | 2015-12-30 | 2016-05-04 | 威海力元海洋生物科技有限公司 | Sea cucumber-chitosan oligosaccharide-selenium preparation and preparation technology thereof |
| CN105595224A (en) * | 2015-12-30 | 2016-05-25 | 威海力元海洋生物科技有限公司 | Sea cucumber dunaliella salina glucosan selenium preparation and preparation process |
| CN105639614A (en) * | 2016-01-05 | 2016-06-08 | 大连真久生物产业有限公司 | Composition taking sea cucumbers and cordyceps sinensis as effective components as well as preparation method and application thereof |
-
2016
- 2016-11-14 CN CN201610998382.0A patent/CN106690121A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1650988A (en) * | 2004-12-13 | 2005-08-10 | 北京阜康仁生物制药科技有限公司 | Chinese medicinal preparation for treating heart brain blood vessel diseases and its preparation method |
| CN101856120A (en) * | 2010-03-23 | 2010-10-13 | 无锡市天赐康生物科技有限公司 | Health food for improving immunity of human body and preparation method thereof |
| CN102579837A (en) * | 2012-03-02 | 2012-07-18 | 安徽圣农生物科技股份有限公司 | Soft dendrobium huoshanense capsule and preparation method thereof |
| CN103211220A (en) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | Health food with function of enhancing immunity and preparation method thereof |
| CN104351612A (en) * | 2014-11-21 | 2015-02-18 | 威海力元海洋生物科技有限公司 | Sea cucumber, lucid ganoderma, glucan and selenium preparation and preparation method thereof |
| CN104489457A (en) * | 2014-11-27 | 2015-04-08 | 扬州日兴生物科技股份有限公司 | Dietary formula containing chitosan oligosaccharide and cordyceps militaris powder for liver cancer patients |
| CN104606659A (en) * | 2015-02-02 | 2015-05-13 | 威海康博尔生物药业有限公司 | Antimicrobial and antiviral oral liquid for regulating metabolism and enhancing immunity |
| CN105079044A (en) * | 2015-09-23 | 2015-11-25 | 李�杰 | Preparation method of soft capsules containing Chinese caterpillar funguses |
| CN105533710A (en) * | 2015-12-30 | 2016-05-04 | 威海力元海洋生物科技有限公司 | Sea cucumber-chitosan oligosaccharide-selenium preparation and preparation technology thereof |
| CN105595224A (en) * | 2015-12-30 | 2016-05-25 | 威海力元海洋生物科技有限公司 | Sea cucumber dunaliella salina glucosan selenium preparation and preparation process |
| CN105639614A (en) * | 2016-01-05 | 2016-06-08 | 大连真久生物产业有限公司 | Composition taking sea cucumbers and cordyceps sinensis as effective components as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 崔秀明等: "《三七新食品原料开发和利用》", 31 January 2015, 云南科技出版 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108935891A (en) * | 2018-05-09 | 2018-12-07 | 安徽过湾农业科技有限公司 | A kind of production method of the selenium-rich pressed candy with radiation-resisting functional |
| IT202000017914A1 (en) * | 2020-07-23 | 2022-01-23 | Meti Biosolutions S R L | FORMULATION FOR USE IN THE TREATMENT OF SIDE EFFECTS RESULTING FROM RADIOTHERAPY |
| EP3943067A1 (en) * | 2020-07-23 | 2022-01-26 | Meti Biosolutions S.r.l. | A formulation for use in the treatmentof radiotherapy-derived side effects |
| CN112641812A (en) * | 2020-12-30 | 2021-04-13 | 广东粤微食用菌技术有限公司 | Fermented cordyceps composition with immunity enhancing effect and preparation method and application thereof |
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Application publication date: 20170524 |