CN110420320A - A kind of Chinese medicine composition for removing gout pathogenesis basis - Google Patents
A kind of Chinese medicine composition for removing gout pathogenesis basis Download PDFInfo
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- CN110420320A CN110420320A CN201910786324.5A CN201910786324A CN110420320A CN 110420320 A CN110420320 A CN 110420320A CN 201910786324 A CN201910786324 A CN 201910786324A CN 110420320 A CN110420320 A CN 110420320A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/46—Hydrolases (3)
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Abstract
The invention discloses a kind of for removing the Chinese medicine composition of gout, the Chinese medicine preparation is made of following raw materials: Abelmoschus Esculentus Linn extract 15-25%, certain kind of berries tea (ampelopsis grossdentata) extract 15-25%, Helianthi extract 10-20%, chicory extract 5-15%, ox bone extract 5-15%, Celeryseed extract 3-8%, the active Nattokinase 4-6% of Semen euryales extract 3-8%, 50000fu/g, semen coicis 3-8%, Poria cocos 3-8%.The Chinese medicine composition can be effectively removed gout, and have no toxic side effect.
Description
Technical field
The invention belongs to field of traditional Chinese medicine formula, more particularly to be it is a kind of remove gout pathogenesis basis Chinese medicine composition match
Side.
Background technique
Gout is a kind of common and complicated arthritis type, and all age group may suffer from this disease, male's disease incidence
Higher than women.Often there is sudden arthritis at night in patient with gout, and morbidity is anxious, and serious pain occurs in joint part
Bitterly, oedema, redness and inflammation, feeling of pain slowly mitigates until disappearance, takes several days or a few weeks are differed.When panic attacks, suffer from
Person can ache in midnight sleep soundly to wake up, and has patient to describe feeling of pain and is burnt equally similar to big toe.The joint of most commonly-occurring disease is
Big toe (medical terminology: first metatarsal bone), but the joint fallen ill is without being limited thereto, is also common in joint, the knee, ancon of hand
Deng.The eventually red and swollen, inflammation of the joint of morbidity is organized to soften after oedema, and limitation of activity finally influences daily life.These diseases
Shape can occur repeatedly, so it is necessary to seeing the doctor in time after occurring strong, unexpected pain once joint, carry out symptom management and
Prevention.
If the consequence of delay is that feeling of pain will be increasingly stronger without treating in time, people is allowed to be difficult to endure.If at this time
It has a fever, inflammation has been had already appeared with regard to explanation.Moreover, joint itself also will receive damage, and sclerotin can be corroded, and cause to close
Section deformation, entire pathogenic process kidney can be also damaged, serious that kidney stone even kidney failure, threat to life can occur.
Cause gout essential reason be internal uric acid level raising, cause lithate in joint and renal tract
Deposition.Therefore, the drug of gout pathogenic factors can be removed to solve the above problems by needing one kind.
The acute attack for widely applying colchicines tablets (injection) treatment gout clinical at present, there is spy in terms of anti-inflammatory analgetic
Other effect, but it is very big to face toxic side effect.It is open in the patent application that application number of invention patent is CN201610294537.2
A kind of sunflower disk small-molecular peptides and preparation method and medical application: the present invention provides a kind of sunflower disk small-molecular peptides and preparation side
Method and medical application are a kind of new plant small molecular peptide, and open sunflower disk small-molecular peptides are treating the doctor in gout
Purposes.The sunflower disk small-molecular peptides, protein molecular weight is small, directly can not be absorption of human body by digestive system, inhale
It receives quickly, efficiently works.Nuo Bei prize winner, which studies alkaline matter of the discovery from seabed deep layer, can effectively neutralize blood uric acid
To treat and prevent gout breaking-out, by its invention " alkaline life liquid " obtain United States Patent (USP) (patent No.: 5,306,511) and
Food and Drug Administration (FDA) certification, product is pure natural, without side-effects, and pregnant woman is available, and the height of medical field is caused to be closed
Note and attention.It is known as exploring the new way of gout prevention and treatment.Safe without side-effects colchicin can be replaced for pain
The curative effect of wind.Patent CN201610294537.2 discloses a kind of sunflower disk small-molecular peptides and preparation method and medical application, is
A kind of new plant small molecular peptide, and medical application of the open sunflower disk small-molecular peptides in treatment gout.The certain herbaceous plants with big flowers
Floral disc small peptide, protein molecular weight is small, directly can not be absorption of human body by digestive system, absorb quickly, efficiently work；It is related to
Extraction and separation process it is simple, it is easily operated, be not necessarily to special installation, reagent no pollution to the environment low in cost, used, be suitble to
In large-scale industrial production.There is significant therapeutic effect for gout, and toxic side effect is small, can take for a long time
With.The patent application is with alkaloid sunflower disk alkali etc. instead of colchicin, and while ensure that curative effect, there is no apparent poison
Side effect, but activate blood circulation and disperse blood clots and be not applied, reduce resultant effect and prevent efficiency for a long time.
The product of the above treatment gout, is based on alkaloid (colchicin, sunflower disk alkali, deep-sea alkaloid substance) anti-inflammatory, town
Bitterly, neutralizing purine sediment rushes the combined application of resistance effect with pseudo-ginseng blood-circulation-invigovating or is used alone, and preferably alleviates gout hair although having
The effect of work, but or have more serious toxic side effect simultaneously or subtract pain anti-trioxypurine merely, cannot remove gout morbidity root
This factor.
Summary of the invention
To solve the above problems, the primary purpose of the present invention is that providing a kind of Chinese traditional medicine composition for removing gout pathogenesis basis
Object, which can be effectively removed gout, and have no toxic side effect.
It is another object of the present invention to provide a kind of Chinese medicine composition for removing gout pathogenesis basis, the Chinese traditional medicine compositions
Object can be effectively removed gout, have no toxic side effect, and formulation of drug is simple and easy to get, low in cost.
It is another object of the present invention to provide a kind of Chinese medicine composition for removing gout pathogenesis basis, the Chinese traditional medicine compositions
Object cost of manufacture is cheap, it is easy to accomplish.
To achieve the above object, technical scheme is as follows:
It is a kind of for removing the Chinese medicine composition of gout, which is made of the raw material of following proportions: Huang Qiu
Certain herbaceous plants with big flowers extract 15-25%, certain kind of berries tea (ampelopsis grossdentata) extract 15-25%, Helianthi extract 10-20%, chicory extract
5-15%, the active natto of ox bone extract 5-15%, Celeryseed extract 3-8%, Semen euryales extract 3-8%, 50000fu/g
Kinases 4-6%, semen coicis 3-8%, Poria cocos 3-8%.
10 kinds of Chinese herbs of formulary (whole integration of drinking and medicinal herbs) of the invention are enlisted, the strong kidney of having concentrated human body to need,
Hematopoiesis, promoting blood circulation, antibacterial, anti-inflammatory, analgesia and other functional ingredient, while having using rich in alkaloid, flavones, enzyme bioactive substance
Imitate anti-trioxypurine, degradation purine sediment, at the same also add flavones+Nattokinase auxiliary activate blood circulation and disperse blood clots and can anti-inflammatory analgesic,
Gumbo kidney tonifying and enriching blood benefit marrow is also increased on this basis, promotion immunity improves to enhance human body vigor in human body
Hematopoiesis function and microcirculation simultaneously strengthen muscles and bones, with biological support alkali, flavones, enzyme anti-trioxypurine and dissolution purine oxygen in human body
Change sediment, removes gout, avoid the morbidity of gout.
The Abelmoschus Esculentus Linn extract, certain kind of berries tea (ampelopsis grossdentata) extract, Helianthi extract, chicory extract, are adopted
Na Shui+alcohol extracts for solvent.
Further, the extracting method of said extracted object is:
Step 1: material is launched；
Step 2: injection pure water (object water ratio 1:8) is warming up to 100 degree of holdings 3-6 hours；
Step 3: filter extracting solution and be concentrated 1.；
Step 4: the alcohol (1:5) of 80% concentration of injection is warming up to 60 degree of holdings 2-4 hours；
Step 5: filter 2. extracting solution and separating alcohol obtain concentrate；
Step 6: 1.+2. mix after dry, crush to obtain extract.
The ox bone extract, Celeryseed extract, Semen euryales extract are by water-soluble extraction, specific extracting method
Are as follows:
Step 1: material is launched；
Step 2: injection pure water (object water ratio 1:8) is warming up to 100 degree of holdings 3-6 hours；
Step 3: it filters extracting solution and it to be concentrated；
Step 4: it first dries and crushes to obtain extract afterwards.
In the present invention, the pharmacological effect effect of each raw material is as follows:
Sunflower, gumbo, witloof, certain kind of berries tea: being rich in total alkaloid, these alkaline soil plant nutriments all have well
Reduce the effect of uric acid dissolution purine sediment.
Witloof: its active principle Cichoric acid, cichory root polyphenol in advance have the function of reducing uric acid and triacylglycerol.
Ox bone extract: the chondroitin and biological active calcium being mainly extracted in ox bone, chondroitin is for treating joint
Bitterly, biological active calcium is then used for supplement calcium.
Celery seed: containing cineol, phosphorus methoxyl group phenol, umbrella flower lactone, apiolin, linolenic acid, flavones, calcium, magnesium, sodium, zinc etc.
Nutrient plays the role of reducing blood lipid, blood pressure, uric acid.
Gorgon fruit: it is with supplementing the kidney to control the nocturnal, the effect of tonifying spleen and stopping diarrhea, eliminating dampness and arresting leucorrhea.
Nattokinase: being the substance for having now been found that best thrombus, and it is living that it can greatly improve the fibrinolytic in blood plasma
Property, find that it can directly dissolve the effect of uric acid in this formula.
Semen coicis, Poria cocos: being traditional side of drying.
Compared with prior art, the invention has the following advantages:
1, this formula rich in peptide molecule protein, flavones, carbohydrate, potassium and gumbo LM (Lepidimoide,
A kind of substance similar to natural hormone) etc. nutritional ingredients can be obviously promoted in human body biological cell activity, strong to play
Kidney qi-restoratives, enhancing physical strength, the effect for improving immunity.Multi-flavor drug (gumbo, celery seed, Gorgon fruit) iron rich in formula
Element and polysaccharide and flavones, mutually actuate, it is easier to embody hematopoiesis effect.And plant general flavone abundant, to human body hematopoiesis
System, immune system, DNA system have fabulous protective effect, anti-inflammatory, antiallergy can be shown, inhibit bacterium, analgesia etc.
Effect, general flavone have the function of that thrombus reduces uric acid simultaneously, can effectively be directed to and merge anti-trioxypurine degradation purine sediment,
Cooperate promoting blood circulation, green blood, kidney tonifying, bone strengthening to promote immunity, gout pathogenesis basis can be reversed in time；
2, gumbo, sunflower, certain kind of berries tea, lettuce chrysanthemum, celery seed, natto are rich in alkaloid, flavones, enzyme biological active matter mass-energy
Effective specific aim anti-trioxypurine degradation purine sediment, cooperation promoting blood circulation, green blood, kidney tonifying, bone strengthening, invigorating the spleen promote immunity, can be in time
Reverse gout pathogenesis basis；
3, raw material is medicinal and edible plant (or ox bone) extract in all formulas, and without side-effects, dietotherapy simultaneously can also
Health-care effect is provided；
3, each Chinese medicine ingredient of the Chinese medicine preparation is easy to get, and the Chinese medicine preparation production method is simple, manufacturing process
It is convenient, fast, and low manufacture cost of the present invention.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the invention is clearly and completely described.
Embodiment 1:
A kind of Chinese medicine composition for removing gout pathogenesis basis, using 60g as dose, specific prescription constitutes as follows:
Abelmoschus Esculentus Linn extract 15%, certain kind of berries tea (ampelopsis grossdentata) extract 20%, Helianthi extract 20%, witloof are extracted
Object 15%, ox bone extract 10%, Celeryseed extract 5%, Semen euryales extract 5% and the active Nattokinase of 50000fu/g
4%, semen coicis 3%, Poria cocos 3%.
According to Chinese medicine preparation prepare decoction method the following steps are included:
1) the every width of decoction is total amount by 60g, is directly weighed in upper ratio；
2) 0.3-5 liter of water is added to decoct to remaining 100-150ml or so, is one；
3) application method: drinking, one dose per day.
Embodiment 2:
A kind of Chinese medicine composition for removing gout pathogenesis basis, the raw material including following weight: is made generation so that 30g/ is brewed
With tea, total amount 300kg composition is taken, specific prescription is weighed according to following ratio:
Abelmoschus Esculentus Linn extract 25%, certain kind of berries tea (ampelopsis grossdentata) extract 25%, Helianthi extract 10%, witloof are extracted
Object 10%, ox bone extract 14%, Celeryseed extract 3%, Semen euryales extract 3% and the active Nattokinase of 50000fu/g
4%, semen coicis 3%, Poria cocos 3%.
According to Chinese medicine preparation prepare alternative tea method the following steps are included:
1) it directly feeds intake in upper ratio and crushes mixing again；
2) industrial packaging is at alternative tea, every packet 30g；
3) application method: every packet steeps 100-300ml boiled water, drinks after water temperature is suitable, and every packet at least connects bubble twice；Work as daily
Tea-drinking, not less than 3 packets.
Embodiment 3:
A kind of Chinese medicine composition for removing gout pathogenesis basis, is fabricated to tablet with 0.5g/ piece, and total amount 1000kg is taken to combine
Object, specific prescription are weighed according to following ratio:
Abelmoschus Esculentus Linn extract 17%, certain kind of berries tea (ampelopsis grossdentata) extract 15%, Helianthi extract 10%, witloof are extracted
Object 5%, ox bone extract 15%, Celeryseed extract 8%, Semen euryales extract 8% and the active Nattokinase of 50000fu/g
6%, semen coicis 8%, Poria cocos 8%
According to Chinese medicine preparation prepare tablet method the following steps are included:
1) directly in upper ratio by upper extract or pulvis mixing；
2) tablet is made according to existing tablet manufacturing technique and packs；
3) application method: consumer is by label guide warm water delivery service.
Embodiment 4:
It is a kind of remove gout pathogenesis basis Chinese medicine composition take total amount 1000kg composition system using No. 2 capsules as standard
It pays, specific prescription is weighed according to following ratio:
Abelmoschus Esculentus Linn extract 18%, certain kind of berries tea (ampelopsis grossdentata) extract 17%, Helianthi extract 12%, witloof are extracted
Object 13%, ox bone extract 5%, Celeryseed extract 7%, Semen euryales extract 8% and the active Nattokinase of 50000fu/g
5%, semen coicis 7%, Poria cocos 8%
According to Chinese medicine preparation prepare capsule method the following steps are included:
1) directly in upper ratio by upper extract or pulvis mixing；
2) it uses the filling soft or hard capsule of existing industrial equipment and packs；
3) application method: consumer is by label guide warm water delivery service.
Embodiment 5:
A kind of Chinese medicine composition for removing gout pathogenesis basis, following prescription weigh the raw material production medicine of 1000kg weight
Cream, each patch is 10g in ointment:
Abelmoschus Esculentus Linn extract 22%, certain kind of berries tea (ampelopsis grossdentata) extract 18%, Helianthi extract 13%, witloof are extracted
Object 8%, ox bone extract 10%, Celeryseed extract 6%, Semen euryales extract 6% and the active Nattokinase of 50000fu/g
6%, semen coicis 5%, Poria cocos 6%
With specific reference to Chinese medicine preparation prepare external-applied ointment method the following steps are included:
1) directly in upper ratio by upper extract or pulvis mixing；
2) plus until medicinal alcohol blendes together paste (slightly match heat preserving agent)；
3) industry applies and is combined into patch (10g) and packs；
4) application method: consumer is attached to each pain spot of gout by label guide and changes a patch daily.
Embodiment 6:
A kind of Chinese medicine composition for removing gout pathogenesis basis, following prescription weigh the raw material production external application of 1000kg weight
Aqua:
Abelmoschus Esculentus Linn extract 19%, certain kind of berries tea (ampelopsis grossdentata) extract 16%, Helianthi extract 14%, witloof are extracted
Object 7%, ox bone extract 8%, Celeryseed extract 7%, Semen euryales extract 8% and the active Nattokinase of 50000fu/g
5%, semen coicis 8%, Poria cocos 8%
According to Chinese medicine preparation prepare external application aqua method the following steps are included:
1) directly in upper ratio by upper extract or pulvis mixing；
2) plus 3 times of medicinal alcohols dissolve and filter to obtain stoste；
3) industry is quantitatively bottled and is packed；
4) application method: consumer guides spray by label or is applied to each pain spot of gout, 4 times a day or more.
According to above-mentioned prescription, the Chinese medicine composition that the present invention is realized, not only that as tablet, capsule, plaster,
Decoction, aqua etc. use, and the system of the other forms such as pill, granule, medicine materical crude slice, syrup can also be fabricated to using the prior art
Agent.
Clinical efficacy is summarized:
1. general data
By to the clinical observation after 82 patient medications, feedback rates 97.6% (80 people carry out effective Feedback), in which: anti-
Especially effective 75 people is presented, 4 people of some effects is fed back, is fed back without 1 people of positive effect.Drug effective percentage of the invention is up to 99%.
2. usage and dosage
It being weighed by extract mixture, daily 3-8g is normal equivalence unit, and alternative tea and decoction dosage turn over 4 times or more,
External application is quantity-unlimiting.
3. diagnostic criteria
(1) gout criterion of cure: 1. urarthritis is not reaccessed, and sick joint, form, function restore normal.
2. no gout calculus and stone in urinary system are formed.3. urinary system checks discovery without exception.4. blood uric acid value is steadily in the long term normal
Range, " a six high rouge " disease relevant to gout are well controlled.
(2) the improvement standard of gout treatment: 1. urarthritis acute attack has controlled substantially, and original arthropathy is
Stablize, not developing deeply.2. tophus and stone in urinary system do not increase again, increase.3. nephrosis stabilizes, renal function makes moderate progress.
4. blood uric acid value is controlled substantially in normal range (NR), fluctuation is little.
(3) null criterion of gout treatment: 1. urarthritis is acute still breaks out, and lesion occurs for joint.2. gout
Stone and stone in urinary system increase, and increase.3. nephrosis aggravates, renal function Continuous Damage.4. blood uric acid value fluctuation increases.
4. therapeutic effect
It is observed in the long-time to 80 groups of sufferers, after persistently taking medicine six months, latter two moon does not recur 75 people again, after improvement
There are within two months interval 4 people of recurrence, without substantially reduced 1 people of symptom, 98% or more total effective rate.
Typical clinical case:
Case 1: Wu Zhengguang, male, 47 years old, diagnostic result was gout.Hospital Physical Examination uric acid is before taking drug of the present invention
586.0umol/L, after taking one week of drug decoction of the present invention, Hospital Physical Examination uric acid is 326.0umol/L, and uric acid is reduced to
Normal level.
Case 2: Wen Haiyang, male, 43 years old, diagnostic result was gout.Hospital Physical Examination uric acid is before taking drug of the present invention
724.0umol/L, after taking one week of drug decoction of the present invention, Hospital Physical Examination uric acid is 469.0umol/L, and uric acid is significantly
Reduce, though not to normal level, very close to.
Case 3: Wang Juan, female, 42 years old, diagnostic result was gout.Hospital Physical Examination uric acid is before taking drug of the present invention
483.0umol/L, after taking one week of drug decoction of the present invention, Hospital Physical Examination uric acid is 227.0umol/L, and uric acid is reduced to
Normal level.
Case 4: Liu Zhiguo, male, 49 years old, diagnostic result was gout.Hospital Physical Examination uric acid is before taking drug of the present invention
622.0umol/L, after taking one week of drug decoction of the present invention, Hospital Physical Examination uric acid is 334.0umol/L, and uric acid is reduced to
Normal level.
Case 5: Liu Cuie, female, 40 years old, diagnostic result was gout.Hospital Physical Examination uric acid is before taking drug of the present invention
524.0umol/L, after taking one week of drug decoction of the present invention, Hospital Physical Examination uric acid is 254.0umol/L, and uric acid is reduced to
Normal level.
To sum up, the Chinese medicine composition provided by the invention for removing gout pathogenesis basis, it is raw rich in alkaloid, flavones, enzyme
Active substances can be effectively for simultaneously anti-trioxypurine degradation purine sediment, and cooperation promoting blood circulation, green blood, kidney tonifying, bone strengthening, invigorating the spleen promotion are exempted from
Epidemic disease power can reverse gout pathogenesis basis in time, for gout therapeutic effect clearly.
Embodiment of above be only preferred embodiments of the present invention will be described, not to the scope of the present invention into
Row limits, and without departing from the spirit of the design of the present invention, this field engineers and technicians make technical solution of the present invention
Various changes and improvements out should all fall into the protection scope that claims of the present invention determines.
Claims (5)
1. a kind of Chinese medicine composition for removing gout pathogenesis basis, which is characterized in that changing Chinese medicine composition is following next raw material
Be made according to weight percent: Abelmoschus Esculentus Linn extract 15-25%, certain kind of berries tea (ampelopsis grossdentata) extract 15-25%, sunflower mention
Take object 10-20%, chicory extract 5-15%, ox bone extract 5-15%, Celeryseed extract 3-8%, Semen euryales extract 3-
The active Nattokinase 4-6% of 8% and 50000fu/g, semen coicis 3-8%, Poria cocos 3-8%.
2. removing the Chinese medicine composition of gout pathogenesis basis as described in claim 1, which is characterized in that the Gorgon fruit can be with
With Chinese yam etc. than substituting.
3. removing the Chinese medicine composition of gout pathogenesis basis as described in claim 1, it is characterised in that the celery seed can be with
By mast etc. than substitution.
4. the Chinese medicine composition of the removing gout pathogenesis basis as described in claim 1,2,3, it is characterised in that the Chinese medicine group
Tablet, hard capsule, soft capsule, oral solution, granule, plaster, decoction, aqua, pill, medicine materical crude slice, syrup can be made by closing object
Any one of agent.
5. removing the Chinese medicine composition of gout pathogenesis basis as described in claim 1, which is characterized in that the Chinese medicine composition
It can be drunk in a manner of Chinese medicine decoction, may be made as alternative tea bubble drink, powdering can also be manufactured and be subsequently processed into various means of food
It is edible.
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| CN111956751A (en) * | 2020-09-14 | 2020-11-20 | 广东仁和康源生物科技有限公司 | Pharmaceutical composition for treating hyperuricemia and preparation method thereof |
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|---|---|---|---|---|
| CN109125639A (en) * | 2018-07-20 | 2019-01-04 | 河北福蕈坊生物科技有限公司 | The Chinese medicine composition for treating gout |
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|---|---|---|---|---|
| CN109125639A (en) * | 2018-07-20 | 2019-01-04 | 河北福蕈坊生物科技有限公司 | The Chinese medicine composition for treating gout |
Cited By (1)
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|---|---|---|---|---|
| CN111956751A (en) * | 2020-09-14 | 2020-11-20 | 广东仁和康源生物科技有限公司 | Pharmaceutical composition for treating hyperuricemia and preparation method thereof |
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