CN108813465A - A kind of fig function chewable tablets and preparation method thereof - Google Patents

A kind of fig function chewable tablets and preparation method thereof Download PDF

Info

Publication number
CN108813465A
CN108813465A CN201810711556.XA CN201810711556A CN108813465A CN 108813465 A CN108813465 A CN 108813465A CN 201810711556 A CN201810711556 A CN 201810711556A CN 108813465 A CN108813465 A CN 108813465A
Authority
CN
China
Prior art keywords
chewable tablets
fruit
powder
function
weight percentage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810711556.XA
Other languages
Chinese (zh)
Inventor
贺亮
程俊文
魏海龙
王衍彬
张建
石从广
冯爱博
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Academy of Forestry
Original Assignee
Zhejiang Academy of Forestry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Academy of Forestry filed Critical Zhejiang Academy of Forestry
Priority to CN201810711556.XA priority Critical patent/CN108813465A/en
Publication of CN108813465A publication Critical patent/CN108813465A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of fig function chewable tablets and preparation method thereof.The fig function chewable tablets consists of the following components in percentage by weight：The chewable tablets auxiliary material of fig fruit powder 5%-35%, fig fruit extract powder 40%-75% and surplus.The chewable tablets auxiliary material is fructose, xylitol, microcrystalline cellulose, cornstarch, maltodextrin, milk-taste essence, potassium sorbate, magnesium stearate and silica.The fig function chewable tablets has the multiple efficacies such as antibacterial, anti-inflammatory, hemostasis, anticancer, treatment sore-throat, treatment hemorrhoid, easy to use, adapts to Modern human populations health care demand.The preparation method of fig function chewable tablets of the present invention, it is easy to operate, it is easily controllable, it is suitable for industrialized production, there is preferable promotional value.

Description

A kind of fig function chewable tablets and preparation method thereof
Technical field
The present invention relates to food, health care product and medicine fields, and in particular to a kind of fig function chewable tablets and its preparation Method.
Background technique
Fig (Ficus carica Linn) is a kind of flowering plant for being under the jurisdiction of Moraceae Ficus, is mainly grown on one The place in a little torrid zones and temperate zone.Fig is full of nutrition, the nutritional ingredient containing a large amount of needed by human body, due to its contain it is a variety of The effective component of different bioactivity has it and keeps fit and healthy, promotes longevity and various effects such as cancer-resisting, can make It is edible, it is also pharmaceutically acceptable, and have invigorating stomach and promoting bower movements, subdhing swelling and detoxicating, wind-damp dispelling and anti-cancer and other effects, it is a kind of natural integration of drinking and medicinal herbs type Health fruit.Some researches show that fig is a kind of food with fine dietotherapy effect, is rich in polysaccharide, flavones, psoralea corylifolia The plurality of active ingredients substance such as element, bergapten, wherein polysaccharide and Flavonoid substances are the important functional activity objects of fig Matter has a variety of physiological active functions such as immunological regulation, hypoglycemic, anti-infective, anti-aging, anticancer, antibacterial.Wang Zhen is refined et al. to be ground Study carefully and extracted polysaccharide in fig with hot water formulation, the recovery rate of polysaccharide is 3.86% (Wang Zhenbin, Liu Jiayou, Ma Haile, Sun Ya It encourages, Wang Lin, Yan Jingkun, Guo Qiang fig polysaccharide optimal extraction technology and its ultrasonically-modified [J] Journal of Agricultural Engineering, 2014,30(10):262-269.)；Yu Xi at et al. using microwave assisting method extract fig in Thick many candies, polysaccharide extract rate 27.6% (Yu Xicheng, Lu Jun, Cao are microwave extraction technology [J] food research and development of people water solubility fig polysaccharide, 2009,30(9):19-23.)。
Fig can be used as potential natural antitumor drug, the research in the field have become domestic and international food and The hot spot of the numerous scholars' research of medicine.
The fruit taste of fig is sweet and refreshing, full of nutrition.Fresh fruit thin skin, seedless, meat is soft, and sweet like honey, mouthfeel is quite It is good.Fresh fruit contains nearly 90% moisture, and the content of nutritional ingredient accounts for 10%, and nutritional ingredient is mainly polysaccharide, flavones, Psoralen Rouge element and bergapten etc.；Organic acid ingredient in fruit mainly has citric acid and a small amount of fumaric acid, succinic acid, third Diacid, pyrrolidine acid, oxalic acid, malic acid, quininic acid, shikimic acid.
Existing fig class product has health protection tea, fruit wine, oral solution, fruit juice, lozenge, crisp chip, effervescent tablet, fruit in the market Piece, health-caring capsule, medicinal extract, dried fruit, preserved fruit, can etc..Such as Chinese patent application CN106212831A discloses a kind of no flower Fruit health protection tea, finally obtained finished product fig epidermis adhere to one layer of bloom, and bloom weight accounts for the 3.2%- of fig weight 3.5%；Polyoses content is in 7.76%-7.82% in bloom, and cane sugar content is in 5.24%-5.3%, and glucose content is in 33%- 35%, fructose content is in 45.8%-46.4%, and mannitol content is in 3.75%-3.8%；The fig health-care tea has heat-clearing Ease constipation, aid digestion, protecting liver and detoxication effect.
A kind of preparation method of fig chewable tablets is disclosed in Chinese patent application CN105995709A, the fig nozzle The parts by weight for chewing each ingredient in piece are as follows：30-50 parts of fig powder, 10-25 parts of fruit vegetable powder, 5-15 parts of sweetener, corrigent 1-3 parts, 2-10 parts of filler, 0.5-4 parts of lubricant.Sweetener is selected from one of oligoisomaltose, mannitol, xylitol Or several any combination；Corrigent is selected from one of citric acid, malic acid, tartaric acid or any several combinations；Filler choosing From one or more of microcrystalline cellulose, hydroxypropylcellulose, silica, maltodextrin any combination；Fruit vegetable powder is selected from mountain One or more of short, bristly hair or beard powder, flue fruit powder, apple powder, mango powder, "Hami" melon powder any combination.
Chinese patent application CN106490527A discloses a kind of fig chewable tablets, the fig chewable tablets, and every 1000 Contain butt fig 200-300g, hydroxypropyl methylcellulose 35-60g, chrysanthemum 20-30g, fructus lycii 10-20g, magnesium stearate in piece 8-10g.Fig is sweet in flavor, mild-natured, there is tonifying spleen benefit stomach, moistening lung and nourishing throat, the effect of relax bowel and defecation；Chrysanthemum has treatment eye fatigue, The curative effect of eye-blurred；Fructus lycii has kidney strengthening the essence, nourishes the liver to improve visual acuity, and blood-enriching tranquillizing promotes the production of body fluid to quench thirst, the effect of moistening lung to arrest cough.The chewing The all ingredients of piece share, and have tonifying spleen benefit stomach, and moistening lung and nourishing throat nourishes the liver to improve visual acuity, the effect of relax bowel and defecation.
In conclusion also added a variety of fruits and vegetables ingredients or medicine food in existing fig chewable tablets other than fig Dual-purpose plant, price are relatively expensive.Fig price is relatively low, and contains a large amount of activity in fig fruit extract Ingredient, including polysaccharide, flavones, vitamin, microelement, amylase, lipase, protein, antifatigue anti senility asparagine Acid, the antihypertensive psoralen of anti-cancer and cancer-preventing and bergapten etc., if single make function former material of fig fruit Material can also play the role of mixing fruits and vegetables, then can reduce required cost.Fig is a kind of nutrition very abundant, is had The effects of moistening lung to arrest cough, invigorating stomach and promoting bower movements, subdhing swelling and detoxicating, anti-inflammation detumescence, throat effect plant, and yield is high, cultivation management It is easy, cheap, economic value is higher.Therefore, as can successfully developing the single function raw material of making of fig fruit Fig chewing flake products will have wider application value.
Summary of the invention
For existing market situation, the present invention provides it is a kind of it is single make of fig fruit function raw material without flower Fruit function chewable tablets, the fig function chewable tablets have antibacterial, anti-inflammatory, treatment sore-throat, alleviate the multiple efficacies such as hemorrhoid, make With conveniently, the health care demand of Modern human populations is adapted to.
The present invention also provides a kind of preparation method of fig function chewable tablets, this method simple processes, production cycle It is short, at low cost, Technological adaptability is strong, have preferable promotional value.
A kind of fig function chewable tablets, consists of the following components in percentage by weight：
Fig fruit powder 5%-35%；
Fig fruit extract powder 40%-75%；
Chewable tablets auxiliary material surplus.
Further preferably：The fig function chewable tablets, consists of the following components in percentage by weight：
Fig fruit powder 15%-30%；
Fig fruit extract powder 50%-65%；
Chewable tablets auxiliary material surplus.
Fig function chewable tablets of the present invention uses specific components, that is, specific dosage fig fruit powder of specific dosage End and fig fruit extract powder can effectively solve fig in the method system being then spray-dried using mashing plus water When standby tablet it is existing because the sugar content of fig is too high and caused by spray drying viscous wall is too high, flour extraction is too low And restrict the technological deficiency of fig chewable tablets preparation.
The fig fruit powder is fig fruit through resulting powder of modes such as crushing.
The fig fruit extract powder selects the fig fruit obtained using Subcritical water chromotagraphy fig fruit Real extract is through the resulting powder of drying.The fig fruit extract powder can substantially reduce glutinous during chewable tablets film-making Degree increases the mobility of raw material mixture, it is made to be easier to prepare tablet.Further preferably, the fig fruit extract powder The preparation method at end, includes the following steps：
Fig fruit is cleaned, obtains fig fruit powder after dry and crushing；By fig fruit powder with Asia Critical is that extracting solution carries out Subcritical water chromotagraphy, and liquid-to-solid ratio is 20mL/g-40mL/g (preferably 30mL/g), extracts pressure and is 1MPa-3MPa, Extracting temperature are 120 DEG C -180 DEG C (preferably 130 DEG C -160 DEG C), extraction time 10min-30min；It obtains The concentrated drying of extract (being preferably concentrated and dried in 55 DEG C of vacuum distillations), freeze-drying, obtain containing fig polysaccharide, flavones, benefit The active fig fruit extract powder of the multicomponents such as bone fat element and bergapten.Liquid-to-solid ratio refers to the volume of subcritical water (mL) with the ratio between the quality (g) of fig fruit powder to be extracted.Under the extraction conditions, water becomes subcritical shape State, the pressure of 1MPa-3MPa and 120 DEG C -180 DEG C at a temperature of solution polarity by highly polar reduction at middle polarity, in this way It is more advantageous to the extraction of the middle polarities substance such as flavones in fig fruit, psoralen and bergapten.Contain flavones, Psoralen Function needed for the fig fruit extract powder of the middle polarities substance such as rouge element and bergapten provides not only chewable tablets Energy ingredient, and it is also greatly reduced the viscosity during chewable tablets film-making, the mobility of raw material mixture is increased, makes it more Easily prepare tablet.
The present invention disposably extracts a large amount of polysaccharide, flavones and a small amount of Psoralen in fig using subcritical water technology Rouge element and bergapten, obtain fig effective component extracts；Advantage：It can be same using the water under the conditions of subcritical state When disposably extract a large amount of polysaccharide, flavones and a small amount of psoralen and bergapten in fig, it is existing Most of extracting methods such as hot water formulation, organic solvent extraction, the polysaccharide or Huang that extract in fig that all can only be single Ketone, polysaccharide and flavones can be extracted simultaneously on a small quantity by having, but can not extract psoralen and bergapten.The present invention exists Under conditions of specific subcritical water, it can reach and disposably extract a large amount of polysaccharide, flavones and a small amount of psoralea corylifolia in fig The purpose of the effective components such as element and bergapten.
Existing chewable tablets auxiliary material can be used in the chewable tablets auxiliary material, it is preferred to use fructose, xylitol, microcrystalline cellulose, Cornstarch, maltodextrin, milk-taste essence, potassium sorbate, magnesium stearate and silica.The main work of the chewable tablets auxiliary material With being the mouthfeel for enhancing chewable tablets, pH value and the mobility for enhancing mixture, convenient for preparing uniform tablet.
In the fig function chewable tablets, the weight percentage of fructose is 0.65%-0.85%, the weight of xylitol Percentage composition is 4%-6%, and the weight percentage of microcrystalline cellulose is 4%-6%, and the weight percentage of cornstarch is 1%-5%, the weight percentage of maltodextrin are 2%-5%, and the weight percentage of milk-taste essence is 0.1%-0.4%, The weight percentage of potassium sorbate is 0.02%-0.08%, and the weight percentage of magnesium stearate is 0.5%-1%, dioxy The weight percentage of SiClx is 1%-1.5%.
The preparation method of the fig function chewable tablets, includes the following steps：
Fig fruit powder, fig fruit extract powder and chewable tablets auxiliary material are uniformly mixed, tabletting obtains nothing Flowers and fruits function chewable tablets.Further preferably：By fig fruit powder, fig fruit extract powder and chewable tablets auxiliary material It is uniformly mixed, tabletting obtains fig function chewable tablets using spray drying process spray at powder after adding water to be beaten.
The condition of the tabletting is：Turntable speed 15r/min-30r/min, filling pressure 12kN-20kN, depth of fill 10mm-20mm.Chewable tablets thickness obtained is uniform under this condition, and friability is low, and hardness is good, delicate mouthfeel.
The specification of the fig function chewable tablets can design as needed, such as specification can be：20g/ piece；Usage and dosage For：It the morning 10,3 at night, suitable for the patient with diseases such as sore-throat, hemorrhoid, can prepare for treating afternoon 10 The health care product and/or drug of sore-throat, hemorrhoid.
For sore-throat as a kind of most common illness of modern society, it is mainly in the cold season in 1 year, flu, almond The diseases such as body inflammation, nasosinusitis and virus infection can cause sore-throat.Since fig is sweet in flavor cool in nature, with subdhing swelling and detoxicating Effect, therefore it has the diseases such as abscess of throat, hoarseness certain therapeutic effect.The present invention is by effective component in fig Fig function chewable tablets is made in extraction, can be preferably using the effective component in fig, to sore-throat, hemorrhoid etc. The patient of disease has good adjuvant treatment effect.
In conclusion fig function chewable tablets of the present invention is a kind of combination of plurality of active ingredients in fig, have Antibacterial, anti-inflammatory, anticancer, treatment sore-throat, alleviates the multiple efficacies such as hemorrhoid at hemostasis, can be used for moistening lung to arrest cough, clearing away heat and moistening the bowels are good for Stomach gut purge, subdhing swelling and detoxicating, wind-damp dispelling, anti-cancer treat sore-throat and hemorrhoid etc..
Subcritical state is a kind of form relative to critical state and supercriticality.Adjusting certain pressure limit It is interior, so that water is still kept liquid condition at 100 DEG C -374 DEG C, this water is known as subcritical water.Under subcritical water and normal temperature and pressure Water have bigger difference in nature, the polarity of subcritical water can be adjusted by control temperature, pressure two ways, thus Achieve the purpose that selective extraction target component.This novel extractive technique is mentioned using subcritical water, it can be in the short period Target component is inside largely extracted, which has many advantages, such as that high-efficient, the period is short, economizes on resources, living extracting plant Property ingredient in terms of be with a wide range of applications.
Fig fruit of the present invention preferably high-quality fresh fig fruit.
The beneficial effects of the invention are that：
1, main component is fig fruit extract powder, the extract powder in fig function chewable tablets of the present invention In contain a large amount of polysaccharide and flavones, also contain a small amount of psoralen and bergapten, in conjunction with fig fruit powder, tool There is antibacterial, anti-inflammatory, hemostasis, anticancer, treatment sore-throat, alleviate the multiple efficacies such as hemorrhoid；Protection throat, pure and fresh mouth can either be played The effect of gas, and there are health and beauty, prophylactic treatment oral cavity FAQs and other effects, it is gentle especially suitable for treatment abscess of throat Solve the diseases such as hemorrhoid.
2, fig function chewable tablets of the present invention is using fig fruit as function raw material, Ficus dual-purpose of drug and food money Source, it is nontoxic, without side-effects, it is full of nutrition；Compared with existing chewable tablets, antibiotic, Bu Huiyin are free of in chewable tablets of the present invention The generation of bacterial drug resistance caused by antibiotic is played, and the auxiliary material added in chewable tablets of the present invention is less, the original containing effective component Material accounts for 65% or more of chewable tablets total weight, can largely retain the unique fragrant of fig.
3, all components in fig function chewable tablets of the present invention are ingredient nontoxic, non-stimulated, that security performance is high, Most of ingredient is extracted form natural plant active constituent, can be safe to use.
4, about health fig product, at present on the market mainly using clearing as the oral spray of healthcare function, lozenge, Based on the dosage forms such as granula, tea bag, cream, chewable tablets of the present invention has simple and fast advantage of taking, and adapts to Modern human populations health care Demand.
5, fig function chewable tablets of the present invention uses the specific components of specific dosage, can effectively solve fig and adopt When preparing tablet with then method that mashing plus water are spray-dried it is existing because the sugar content of fig is too high and caused by The viscous wall of spray drying is too high, flour extraction is too low and restricts technological deficiency prepared by fig chewable tablets；Matched using the present invention Side can use simple preparation method and prepare tablet, and tablet yield rate is up to 100%.
6, the preparation method of fig function chewable tablets of the present invention, using subcritical water technology disposably from fig fruit In extracted the beneficial effective component of a variety of pairs of human bodies such as polysaccharide, flavones, psoralen, bergapten；It is easy to operate, easily In control, it is suitable for industrialized production, there is preferable promotional value.
Detailed description of the invention
Fig. 1 is the HPLC chromatogram of psoralen content in 1 fig function chewable tablets of the embodiment of the present invention；
Fig. 2 is the HPLC chromatogram of psoralen content in 3 fig function chewable tablets of the embodiment of the present invention.
Specific embodiment
In the following with reference to the drawings and specific embodiments, the present invention is further explained.It should be understood that these embodiments are merely to illustrate The present invention rather than limit the scope of the invention.In addition, it should also be understood that, after reading the content that the present invention lectures, ability Field technique personnel can make various changes and modification to the present invention, and such equivalent forms also belong to the application appended claims Book limited range.
Fig fruit powder is to obtain fig fruit after being cleaned, crush and dried using existing fig fruit Powder.
Embodiment 1
The preparation method of fig function chewable tablets is as follows：
(1) preparation of fig fruit extract powder：
(1.1) it extracts：Fig fruit powder is obtained after being cleaned, crushed and dried using existing fig fruit； Fig fruit powder will be extracted to pressure to adjust to 1MPa under sub-critical water extraction, Extracting temperature is adjusted to 160 DEG C, liquid material Than for 30mL/g, extraction time 30min, extract in fig a large amount of polysaccharide, flavones and a small amount of psoralen and Bergapten obtains extract.
(1.2) it is concentrated, is lyophilized：Obtained extract is concentrated and dried through 55 DEG C of vacuum distillations, is lyophilized, and obtains containing fig The active fig fruit extract powder of the multicomponents such as polysaccharide, flavones, psoralen and bergapten.
(2) preparation of fig function chewable tablets：
(2.1) it dusts, mixed-powder：By chewable tablets auxiliary material fructose, xylitol, microcrystalline cellulose, cornstarch, malt paste Essence, milk-taste essence, potassium sorbate, magnesium stearate, silica and fig fruit extract powder and fig fruit powder It is uniformly mixed with spray dryer spray at powder after adding water to be beaten.Wherein the weight percentage of each component is as follows：Fig Fruit extract powder 50%, fig fruit powder 30%, fructose 0.75%, xylitol 5%, microcrystalline cellulose 4%, corn Starch 5%, maltodextrin 3%, milk-taste essence 0.2%, potassium sorbate 0.05%, magnesium stearate 0.8% and silica 1.2%.
(2.2) tabletting：Uniformly mixed powder is put into tabletting machine, wherein tablet press machine turntable speed 20r/min, fill Power 15kN, depth of fill 18mm are tamped, fig function chewable tablets is obtained；Specification is 20g/ piece.It wherein dusts, in tableting processes Viscous wall is low, flour extraction is high, tablet yield rate 100%.
Embodiment 2
The preparation method of fig function chewable tablets is as follows：
(1) preparation of fig fruit extract powder：
(1.1) it extracts：Fig fruit powder is obtained after being cleaned, crushed and dried using existing fig fruit； Fig fruit powder will be extracted to pressure to adjust to 1.5MPa under sub-critical water extraction, Extracting temperature is adjusted to 150 DEG C, liquid Material extracts a large amount of polysaccharide, flavones and a small amount of psoralen in fig than being 20mL/g, extraction time 10min And bergapten, obtain extract.
(1.2) it is concentrated, is lyophilized：Obtained extract is concentrated and dried through 55 DEG C of vacuum distillations, is lyophilized, and obtains containing fig The active fig fruit extract powder of the multicomponents such as polysaccharide, flavones, psoralen and bergapten.
(2) preparation of fig function chewable tablets：
(2.1) it dusts, mixed-powder：By chewable tablets auxiliary material fructose, xylitol, microcrystalline cellulose, cornstarch, malt paste Essence, milk-taste essence, potassium sorbate, magnesium stearate, silica and fig fruit extract powder and fig fruit powder It is uniformly mixed with spray dryer spray at powder after adding water to be beaten.Wherein the weight percentage of each component is as follows：Fig Fruit extract powder 60%, fig fruit powder 20%, fructose 0.65%, xylitol 6%, microcrystalline cellulose 6%, corn Starch 2.87%, maltodextrin 2%, milk-taste essence 0.4%, potassium sorbate 0.08%, magnesium stearate 1% and silica 1 %.
(2.2) tabletting：Uniformly mixed powder is put into tabletting machine, wherein tablet press machine turntable speed 30r/min, fill Power 12kN, depth of fill 20mm are tamped, fig function chewable tablets is obtained；Specification is 20g/ piece.It wherein dusts, in tableting processes Viscous wall is low, flour extraction is high, tablet yield rate 100%.
Embodiment 3
The preparation method of fig function chewable tablets is as follows：
(1) preparation of fig fruit extract powder：
(1.1) it extracts：Fig fruit powder is obtained after being cleaned, crushed and dried using existing fig fruit； Fig fruit powder will be extracted to pressure to adjust to 3MPa under sub-critical water extraction, Extracting temperature is adjusted to 130 DEG C, liquid material Than for 40mL/g, extraction time 22min, extract in fig a large amount of polysaccharide, flavones and a small amount of psoralen and Bergapten obtains extract.
(1.2) it is concentrated, is lyophilized：Obtained extract is concentrated and dried through 55 DEG C of vacuum distillations, is lyophilized, and obtains containing fig The active fig fruit extract powder of the multicomponents such as polysaccharide, flavones, psoralen and bergapten.
(2) preparation of fig function chewable tablets：
(2.1) it dusts, mixed-powder：By chewable tablets auxiliary material fructose, xylitol, microcrystalline cellulose, cornstarch, malt paste Essence, milk-taste essence, potassium sorbate, magnesium stearate, silica and fig fruit extract powder and fig fruit powder It is uniformly mixed with spray dryer spray at powder after adding water to be beaten.Wherein the weight percentage of each component is as follows：Fig Fruit extract powder 65%, fig fruit powder 15%, fructose 0.85%, xylitol 4%, microcrystalline cellulose 5%, corn Starch 3.03%, maltodextrin 5%, milk-taste essence 0.1%, potassium sorbate 0.02%, magnesium stearate 0.5% and silica 1.5%.
(2.2) tabletting：Uniformly mixed powder is put into tabletting machine, wherein tablet press machine turntable speed 15r/min, fill Power 20kN, depth of fill 10mm are tamped, fig function chewable tablets is obtained；Specification is 20g/ piece.It wherein dusts, in tableting processes Viscous wall is low, flour extraction is high, tablet yield rate 100%.
Comparative example 1 is only with fig fruit extract powder
In addition to " the preparation of (2) fig function chewable tablets：(2.1) it dusts, mixed-powder：By chewable tablets auxiliary material fructose, wood Sugar alcohol, microcrystalline cellulose, cornstarch, maltodextrin, milk-taste essence, potassium sorbate, magnesium stearate, silica and fig Fruit extract powder uses spray dryer spray at powder after adding water to be beaten, be uniformly mixed.The wherein weight percent of each component Content is as follows：Fig fruit extract powder 80%, fructose 0.75%, xylitol 5%, microcrystalline cellulose 4%, cornstarch 5%, maltodextrin 3%, milk-taste essence 0.2%, potassium sorbate 0.05%, magnesium stearate 0.8% and silica 1 .2%." it Outside, remaining operation obtains fig chewable tablets with embodiment 1；Specification is 20g/ piece.It wherein dusts, glue wall in tableting processes Height, flour extraction are low, tablet yield rate 80%.
Comparative example 2 is only with fig fruit powder
In addition to " the preparation of (2) fig function chewable tablets：(2.1) it dusts, mixed-powder：By chewable tablets auxiliary material fructose, wood Sugar alcohol, microcrystalline cellulose, cornstarch, maltodextrin, milk-taste essence, potassium sorbate, magnesium stearate, silica and fig Fruit powder uses spray dryer spray at powder after adding water to be beaten, be uniformly mixed.Wherein the weight percentage of each component is such as Under：Fig fruit powder 80%, fructose 0.75%, xylitol 5%, microcrystalline cellulose 4%, cornstarch 5%, maltodextrin 3%, milk-taste essence 0.2%, potassium sorbate 0.05%, magnesium stearate 0.8% and silica 1 .2%." except, remaining operation With embodiment 1, fig chewable tablets is obtained；Specification is 20g/ piece.It wherein dusts, glue that wall is high, flour extraction is low in tableting processes, Tablet yield rate 75%.
Here is the embodiment to analysis of effective component in fig chewable tablets：
Embodiment 4：Measurement of the polysaccharide content in fig chewable tablets
(1) chewable tablets extracts：Accurately sample 2.0g is weighed (to be equivalent to the amount of polysaccharide quality about 400mg, be denoted as W, unit G), it sets and adds redistilled water 45ml in test tube, be centrifuged after heat 3h on boiling water bath, being cooled to room temperature, supernatant collection is spare. Precipitating plus 30ml redistilled water carry out second extraction, and extracting method is same as above.Merge supernatant twice, 100ml is settled to, as filtering Liquid (is denoted as V1, units/ml).
Above-mentioned filtered fluid 1.0ml is accurately drawn, is placed in 10ml centrifuge tube, dehydrated alcohol 4ml is added, after mixing, 4 DEG C quiet 6h is set, is centrifuged, discards supernatant liquid.80% (volume ratio) ethyl alcohol number milliliter rinse of residue is buckled on filter paper, operates 3- repeatedly 4 times.Residue is sufficiently dissolved with water and (can suitably heat 60 DEG C of <), is cooled to room temperature, and constant volume (is remembered to 50ml as sample liquid For V2, units/ml).
(2) sample measures
Pipette samples liquid 1.0ml (is denoted as V3, units/ml) and (it is equivalent to the polysaccharide of 40 μ g or so, if polysaccharide amount is excessively high or mistake It is low to make optical density ODIt surveysOptimum range more than 0.2-0.6, increases and decreases the uptake of sample liquid as one sees fit, but must not exceed 2ml, if super Cross, need to increase the sample amount of weighing, that is, increase the amount of weighing of W), add water to be supplemented to 2.00ml, is shaken with swirl mixing device even, so After 6% phenol 1.0ml is added, with swirl mixing device shake it is even, then plus the 5ml concentrated sulfuric acid, shake rapidly even.It is placed at room temperature for 5min, then 15min is kept the temperature in boiling water bath, cools down 5min with tap water, then even with swirl mixing device vibration, it is close that light is measured at wavelength 490nm Spend (ODIt surveys).According to ODIt surveysV is checked in standard curve3It is equivalent to the volume number V of glucose standards solution4, units/ml.
(3) it calculates
Thick many candies (with glucose meter) g/20g=(C × V1×V2×V4)/(V3×W×10000)×4.5；
C：The concentration of glucose standards solution, μ g/ml；
V1：The volume of constant volume, units/ml when sample extraction；
V2：The volume of constant volume, units/ml when sample alcohol hypostasis dissolves；
V3：The volume of sample, ml；
V4：According to ODIt surveysV is checked in standard curve3It is equivalent to the volume number of glucose standards solution, ml；
W：Weigh the quality of sample, unit g；
Coefficient 4.5 is the amount of translation of glucose and polysaccharide.
Three repeated experiments are carried out to embodiment 1,2,3 respectively, are averaged, the measurement result of embodiment 1-3 is shown in Table 1.
Three repeated experiments are carried out to the fig chewable tablets in comparative example 1-2 using identical method, is averaged, surveys Surely it the results are shown in Table 1.
Embodiment 5：The measurement of flavones content in fig function chewable tablets
Take the filtered fluid in 5mL chewable tablets extracting solution i.e. 4 step of embodiment (1) in 50mL volumetric flask, with quality percentage 30% ethanol water of concentration is supplemented to 25mL, and 1.4mL mass percentage concentration 0.5%NaNO is added2Aqueous solution shakes up, and places After 6min, 1.4mL mass percentage concentration 10%Al (NO is added3)3Aqueous solution adds 10mL 1mol/L NaOH water after 6min Solution mixes, is supplemented to 50ml with 30% ethanol water of mass percentage concentration, is measured at 510nm after 10min with microplate reader The light absorption value of flavone extractive obtains the concentration of flavone extractive according to formula, and then calculates flavones content.
Flavones content calculation formula：E (mg/g)=(C × V × N)/M
In formula：C is flavone extractive concentration, mg/L；V is flavone extractive volume, L；N is extension rate；M is raw material nozzle Chew tablet quality, g.
Three repeated experiments are carried out to embodiment 1,2,3 respectively, are averaged, the measurement result of embodiment 1-3 is shown in Table 1.
Three repeated experiments are carried out to the fig chewable tablets in comparative example 1-2 using identical method, is averaged, surveys Surely it the results are shown in Table 1.
Embodiment 6：The measurement of psoralen content in fig function chewable tablets
(1) ultrasonic method pretreatment sample：
Sample (fig function chewable tablets) 30min, ultrasound are impregnated with the methanol aqueous solution of mass percentage concentration 75% 60min is used for the extraction of test sample.
(2) HPLC chromatogram condition and system suitability chromatographic column：
Merck-lichrospher RP-18 chromatographic column (4mm × 250mm, 5 μm)；Mobile phase：Acetonitrile-water (35:65, body Product ratio), flow velocity：1.0mL/min, column temperature:35℃；Detection wavelength:222nm.
(3) preparation of embodiment sample solution：
It takes through the pretreated fig function chewable tablets powder 3g of ultrasonic method in step (1), it is accurately weighed, set 250mL In flask, add chloroform 50mL water-bath refluxing extraction 3h, extracting solution is evaporated, and residue adds methanol to dissolve and is settled to 10mL, shakes It is even, with (0.45 μm) of miillpore filter filter, take filtrate to get.
(4) prepared by reference substance solution:
Take psoralen and bergapten reference substance appropriate, it is accurately weighed, add methanol to make to dissolve, every 1mL is made containing benefit The solution of bone fat element 0.12mg and bergapten 0.03mg.Every 1mL is respectively prepared containing psoralen in accurate solution of drawing again 0.012,0.024,0.048,0.096,0.12mg and bergapten 0.003,0.006,0.012,0.024,0.03mg are Column reference substance solution.
(5) it measures：
It is accurate respectively to draw above-mentioned reference substance solution and each 10 μ L of sample introduction of 1,2,3 solution of embodiment, liquid chromatograph is injected, Measurement, the measurement result of embodiment 1 are shown in Fig. 1, and the measurement result of embodiment 3 is shown in Fig. 2, and the testing result of embodiment 1-3 is shown in Table 1.
Three repeated experiments are carried out to the fig chewable tablets in comparative example 1-2 using identical method, is averaged, surveys Surely it the results are shown in Table 1.
Active constituent content contrast table in 1 20g fig chewable tablets of table
1 data of table are shown, under the premise of function raw material dosage is identical, polysaccharide in fig function chewable tablets of the present invention, The content of the effective components such as flavones, psoralen and bergapten is significantly increased compared with comparative example.
Embodiment 7：The effect of fig function chewable tablets is to hemorrhoid
Case chooses 50 (in March, 2018 in May, 2018 Zhejiang Provincial People's Hospital out-patient), is participating in test Before, cut out the drug that all pairs of hemorrhoid play alleviation.Male 28, female 22 in 50 patients；It age -78 years old 19 years old, puts down (31.3 ± 1.05) year；The course of disease -17 years 0.8 year, average (2.7 ± 0.84) year；Internal piles 12, external piles 15, mixed hemorrhoid 23 Example.Be randomly divided into 5 groups, daily respectively eat the embodiment of the present invention 1,2,3 product, the morning 10, afternoon 10, at night 3.
Work out criterion of therapeutical effect reference《New Chinese medicine guideline of clinical investigations (tentative)》.1. fully recovering:Patient symptom, sign It disappears or basic disappearance, syndrome integral value reduces >=95%.2. effective:It is obviously improved in terms of patient symptom, sign, syndrome product Divide and reduces >=70%.3. effectively:It take a favorable turn in terms of patient symptom, sign, syndrome integral reduces >=30%.4. invalid:Patient Symptom, sign are not improved, or even are aggravated, and syndrome integral reduces < 30%.
The obvious effective rate of the cure rate of total effective rate=1.+2.+3. efficient
Using SPSS19.0 software, x2Enumeration data improvement rate is compared in inspection, indicated by mean ± standard deviation (x ± s) in terms of Amount data, ordered categorization data are examined with Kruskal-Wallis H and are carried out, and are examined using t and are carried out comparison among groups analysis, two-by-two Compare and carry out (α=0.05) by adjusting α level, indicates that difference is statistically significant with P < 0.05.After edible 10 days, with without, Gently, in, 4 ranks are weighed by symptom and sign classification, are denoted as 0,1,2,3 point respectively, the chewing of fig function is taken to them Treatment situation and sign before and after piece are evaluated, and are shown in Table 2.As can be seen from Table 2, by hematochezia, haemorrhoids abjection, anus The hemorrhoid patients of fig function chewable tablets were taken in the pretherapy and post-treatment comparison of discomfort, anus pain, Anal edema etc. Disease symptoms are alleviated, and significant effect is produced, and it is aobvious to illustrate that fig function chewable tablets plays treatment hemorrhoid The curative effect of work.
Table 2 takes the treatment situation and sign evaluation before and after fig function chewable tablets
Note:With take it is preceding compared with, * indicate P < 0.05 (data compare with significant difference).
Embodiment 8：The effect of fig function chewable tablets is to sore-throat
Case chooses 50 (in March, 2018 in May, 2018 Zhejiang Provincial People's Hospital out-patient), is participating in test Before, cut out the drug that all pairs of sore-throats play alleviation.Male 23, female 27 in 50 patients；Age -55 years old 19 years old, Average (27.3 ± 1.05) year；The course of disease -17 years 0.8 year, average (2.7 ± 0.84) year；Exclude the serious changes such as the heart, lung, kidney, liver Person is randomly divided into 5 groups, and (first group and second group is taken embodiment 1 to the product of the edible embodiment of the present invention 1,2,3 respectively daily Product, third group takes the product of embodiment 2, the 4th group and the 5th group product for taking embodiment 3), the morning 10, afternoon 10, at night 3.It is assessed using VAS visual analogue scales, 0 point：Substantially painless；1 point -3 points：Mild pain；4 points- 6 points：Moderate pain；7 points -9 points：Severe pain；10 points：Sharp ache.It is analyzed using SPSS19.0 software, enumeration data It is indicated with percentage (%), with P<0.05 is statistically significant for difference.Take the VAS visual simulation before and after fig chewable tablets Scoring is shown in Table 3.As can be seen from Table 3, the sore-throat patient for taking fig function chewable tablets is for the symptom had sore throat Mitigated, produce significant effect, illustrates that fig function chewable tablets plays certain curative effect for treatment sore-throat.
Table 3 takes the VAS visual analogue scale before and after fig function chewable tablets
Time First group Second group Third group 4th group 5th group
Before treatment 6.4±1.5 6.1±1.7 5.7±1.4 4.7±1.1 5.1±1.2
After treatment 5.4±1.5* 4.7±1.5* 4.1±1.1* 4.5±1.4* 4.2±1.1*
Note:Compared with before treatment, * indicates P < 0.05 (data compare with significant difference).
The variation of parameter has no effect on the essential effect of product in fig function formula of chewable tablets of the present invention.System of the present invention The preparation that the variation of parameter has no effect on product in Preparation Method nor affects on the essential effect of product, therefore preparation method of the present invention The preparation of product can be achieved in the combination of middle arbitrary parameter.Details are not described herein.

Claims (10)

1. a kind of fig function chewable tablets, which is characterized in that consist of the following components in percentage by weight：
Fig fruit powder 5%-35%；
Fig fruit extract powder 40%-75%；
Chewable tablets auxiliary material surplus.
2. fig function chewable tablets according to claim 1, which is characterized in that by following components in percentage by weight group At：
Fig fruit powder 15%-30%；
Fig fruit extract powder 50%-65%；
Chewable tablets auxiliary material surplus.
3. fig function chewable tablets according to claim 1 or 2, which is characterized in that the fig fruit extract Powder selects the fig fruit extract obtained using Subcritical water chromotagraphy fig fruit through the resulting powder of drying.
4. fig function chewable tablets according to claim 3, which is characterized in that the fig fruit extract powder Preparation method, include the following steps：
Fig fruit is cleaned, obtains fig fruit powder after dry and crushing；By fig fruit powder with subcritical Water is that extracting solution carries out Subcritical water chromotagraphy, liquid-to-solid ratio 20mL/g-40mL/g, and extraction pressure is 1MPa-3MPa, Extracting temperature It is 120 DEG C -180 DEG C, extraction time 10min-30min；The concentrated drying of obtained extract, freeze-drying, obtain fig fruit Real extract powder.
5. fig function chewable tablets according to claim 1 or 2, which is characterized in that the chewable tablets auxiliary material uses fruit Sugar, xylitol, microcrystalline cellulose, cornstarch, maltodextrin, milk-taste essence, potassium sorbate, magnesium stearate and silica.
6. fig function chewable tablets according to claim 5, which is characterized in that in the fig function chewable tablets, The weight percentage of fructose is 0.65%-0.85%, and the weight percentage of xylitol is 4%-6%, microcrystalline cellulose Weight percentage is 4%-6%, and the weight percentage of cornstarch is 1%-5%, the weight percentage of maltodextrin For 2%-5%, the weight percentage of milk-taste essence is 0.1%-0.4%, and the weight percentage of potassium sorbate is 0.02%- 0.08%, the weight percentage of magnesium stearate is 0.5%-1%, and the weight percentage of silica is 1%-1.5%.
7. the preparation method of fig function chewable tablets according to claim 1-6, which is characterized in that including with Lower step：
Fig fruit powder, fig fruit extract powder and chewable tablets auxiliary material are uniformly mixed, tabletting obtains fig Function chewable tablets.
8. preparation method according to claim 7, which is characterized in that the condition of the tabletting is：Turntable speed 15r/ Min-30r/min, filling pressure 12kN-20kN, depth of fill 10mm-20mm.
9. fig function chewable tablets according to claim 1-6 is being prepared for treating sore-throat, hemorrhoid Application in drug.
10. fig function chewable tablets according to claim 1-6 is being prepared for treating sore-throat, hemorrhoid Application in health care product.
CN201810711556.XA 2018-07-03 2018-07-03 A kind of fig function chewable tablets and preparation method thereof Pending CN108813465A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810711556.XA CN108813465A (en) 2018-07-03 2018-07-03 A kind of fig function chewable tablets and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810711556.XA CN108813465A (en) 2018-07-03 2018-07-03 A kind of fig function chewable tablets and preparation method thereof

Publications (1)

Publication Number Publication Date
CN108813465A true CN108813465A (en) 2018-11-16

Family

ID=64135282

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810711556.XA Pending CN108813465A (en) 2018-07-03 2018-07-03 A kind of fig function chewable tablets and preparation method thereof

Country Status (1)

Country Link
CN (1) CN108813465A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110024986A (en) * 2019-05-05 2019-07-19 四川农业大学 A kind of fig functionality chewable tablets and preparation method thereof
CN110916041A (en) * 2019-12-05 2020-03-27 山东药品食品职业学院 Deep processed fig product and preparation method thereof
CN117783408A (en) * 2023-12-28 2024-03-29 浙江景岳堂药业有限公司 Quality control method for fig formula particles

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593480A (en) * 2004-07-02 2005-03-16 陈小保 Fig buccal tablet and its preparing process
CN101085040A (en) * 2007-06-21 2007-12-12 陈小保 Health care food suitable for hemorrhoid patients
CN101391053A (en) * 2007-09-18 2009-03-25 王丽 Traditional Chinese medicine composition for treating hemorrhoid
CN101584750A (en) * 2009-07-10 2009-11-25 山东大学威海分校 Compound fig preparation
CN101843665A (en) * 2010-06-01 2010-09-29 山东大学 Fig leaf extract lozenges
CN102309738A (en) * 2010-07-09 2012-01-11 居华 Throat-clearing and pharyngitis-treating buccal tablet
CN103393756A (en) * 2010-06-30 2013-11-20 杨红宇 Externally-applied hemorrhoid drug
CN104622967A (en) * 2013-11-13 2015-05-20 天津药物研究院 Ficus carica containing pharmaceutical composition as well as preparation method and applications thereof
CN105995709A (en) * 2016-05-25 2016-10-12 齐鲁工业大学 Fig chewable tablet and preparation method thereof
CN106490527A (en) * 2016-09-06 2017-03-15 威海云睿信息科技有限公司 A kind of fig chewable tablets
CN106511471A (en) * 2016-11-30 2017-03-22 浙江省林业科学研究院 Fig oral cavity spray and preparation method thereof
CN106943489A (en) * 2017-04-10 2017-07-14 牡丹江医学院 A kind of Chinese medicine composition of General surgical treatment hemorrhoid and preparation method thereof
CN107308213A (en) * 2017-06-16 2017-11-03 山东岐伯堂生物科技有限公司 A kind of fig effervescent tablet and its production method

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593480A (en) * 2004-07-02 2005-03-16 陈小保 Fig buccal tablet and its preparing process
CN101085040A (en) * 2007-06-21 2007-12-12 陈小保 Health care food suitable for hemorrhoid patients
CN101391053A (en) * 2007-09-18 2009-03-25 王丽 Traditional Chinese medicine composition for treating hemorrhoid
CN101584750A (en) * 2009-07-10 2009-11-25 山东大学威海分校 Compound fig preparation
CN101843665A (en) * 2010-06-01 2010-09-29 山东大学 Fig leaf extract lozenges
CN103393756A (en) * 2010-06-30 2013-11-20 杨红宇 Externally-applied hemorrhoid drug
CN102309738A (en) * 2010-07-09 2012-01-11 居华 Throat-clearing and pharyngitis-treating buccal tablet
CN104622967A (en) * 2013-11-13 2015-05-20 天津药物研究院 Ficus carica containing pharmaceutical composition as well as preparation method and applications thereof
CN105995709A (en) * 2016-05-25 2016-10-12 齐鲁工业大学 Fig chewable tablet and preparation method thereof
CN106490527A (en) * 2016-09-06 2017-03-15 威海云睿信息科技有限公司 A kind of fig chewable tablets
CN106511471A (en) * 2016-11-30 2017-03-22 浙江省林业科学研究院 Fig oral cavity spray and preparation method thereof
CN106943489A (en) * 2017-04-10 2017-07-14 牡丹江医学院 A kind of Chinese medicine composition of General surgical treatment hemorrhoid and preparation method thereof
CN107308213A (en) * 2017-06-16 2017-11-03 山东岐伯堂生物科技有限公司 A kind of fig effervescent tablet and its production method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
周炯隆: "无花果的保健功能及产品开发 ", 《福建轻纺》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110024986A (en) * 2019-05-05 2019-07-19 四川农业大学 A kind of fig functionality chewable tablets and preparation method thereof
CN110916041A (en) * 2019-12-05 2020-03-27 山东药品食品职业学院 Deep processed fig product and preparation method thereof
CN117783408A (en) * 2023-12-28 2024-03-29 浙江景岳堂药业有限公司 Quality control method for fig formula particles
CN117783408B (en) * 2023-12-28 2024-05-14 浙江景岳堂药业有限公司 Quality control method for fig formula particles

Similar Documents

Publication Publication Date Title
CN102198262B (en) Chinese medicine preparation for treating infant rotavirus enteritis and preparation method thereof
CN102784363B (en) Traditional Chinese medicine composition for treating pancreatic cancer and preparation method thereof
CN104398986A (en) Tranquilization and brain tonifying epimedium herb oral liquid and preparation method thereof
CN103446385A (en) Traditional Chinese medicine preparation for treating diabetic complications
CN103168883A (en) Pathogenic microorganism preventing antiviral tea beverage granules capable of boosting immunity and preparation method thereof
CN108813465A (en) A kind of fig function chewable tablets and preparation method thereof
CN104857154A (en) Traditional Chinese medicine composition for treating three-high diseases and preparation method therefor
CN105125946A (en) Gardenia oral liquid clearing away heart fire and relieving restlessness and preparing method thereof
CN108813610A (en) A kind of saussurea involucrata composition and its application for improving immunity
CN108813501A (en) With the relieving cough and reducing sputum health honey paste relievingd asthma and adjust function of human body of clearing heat and moistening lung
CN105076617A (en) Tartary buckwheat tea and preparation method thereof
CN104771595B (en) A kind of Chinese medicine composition of strengthen immunity and preparation method thereof
CN108813500B (en) Health-preserving honey paste with effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves and regulating human body functions
CN103238834B (en) A kind of composition treating pruitus and preparation method thereof
CN102626471B (en) Traditional Chinese medicine composition with effects of anti-anaphylaxis, desensitization, repair and regeneration
CN102100390A (en) Preparation technology for selenium tea and morinda citrifolia functional beverage
CN112245527A (en) Preparation method of active polysaccharide extract, functional beverage and effervescent granule with homology of medicine and food
CN105343660A (en) Traditional Chinese medicinal preparation for treating peripheral vertigo and preparation method of traditional Chinese medicinal preparation
CN105560984B (en) Traditional Chinese medicine composition capable of boosting qi and invigorating spleen
CN104306817A (en) Pharmaceutical composition for treating ephemeral fever of dairy cow and preparation method thereof
CN114712466B (en) Medicine with weight-reducing and beautifying effects and preparation method thereof
CN103520644B (en) Traditional Chinese medicine composition used for treating phlegm stagnation type hyperlipidaemia and preparation method of composition
CN114259517B (en) Traditional Chinese medicine aromatherapy gel for treating allergic rhinitis
CN105267815A (en) Spray for treating infant lung-kidney-deficiency type asthma and preparing method thereof
CN104352974A (en) Ciliatenerve knotweed root-containing traditional Chinese medicine composition for treating diabetes

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20181116