CN106511471A - Fig oral cavity spray and preparation method thereof - Google Patents
Fig oral cavity spray and preparation method thereof Download PDFInfo
- Publication number
- CN106511471A CN106511471A CN201611077374.9A CN201611077374A CN106511471A CN 106511471 A CN106511471 A CN 106511471A CN 201611077374 A CN201611077374 A CN 201611077374A CN 106511471 A CN106511471 A CN 106511471A
- Authority
- CN
- China
- Prior art keywords
- fructus fici
- fruit
- extract
- powder
- oral spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000003128 head Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 238000011645 inflammation animal model Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940127249 oral antibiotic Drugs 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000013324 preserved food Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000021264 seasoned food Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- WDFRNBJHDMUMBL-OICFXQLMSA-M sodium;(4r)-4-[(3r,5s,7r,8r,9s,10s,13r,14s,17r)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)CC1 WDFRNBJHDMUMBL-OICFXQLMSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses fig oral cavity spray and a preparation method thereof. The fig oral cavity spray is composed of, on the basis of 1000ml, 50 g to 150 g of fig fruit extract freeze-dried powder, 2 g to 6 g of preservative, 40 g to 80 g of absorption promoter and the balance deionized water. The absorption promoter is prepared from Herba Clinopodii Chinensis saponin and cholate. The fig oral cavity spray has the effects of inhibiting bacteria, diminishing inflammation, stopping bleeding, smoothing the throat, removing odors and the like, is convenient to use and meets the needs of modern people for oral hygiene and health. The preparation method of the fig oral cavity spray is easy to operate and control and suitable for industrial production and has high promotional value.
Description
Technical field
The present invention relates to food and field of health care products, and in particular to a kind of Fructus Fici oral spray and preparation method thereof.
Background technology
Fructus Fici (Ficus caricaLinn.) also known as mamoncillo, syconium, bright mouth fruit, Fructus Fici Beecheyanae, Fructus Fici Heteromo, Gu Duzi,
Category Moraceae Ficus deciduous tree or shrub, are mainly grown on the torrid zone and temperate zone, belong to subtropical zones defoliation small arbor, and trunk is high, tree crown
Greatly, blade face width, two season of autumn in summer result.Fig fruit thin skin is seedless, and meat is soft, and local flavor is sweet, containing various saccharides material,
Flavone compound, organic acid, protein, trace element and vitamin C (Vc) isoreactivity composition, nutrition very abundant, have
Very high nutritive value and medical value.Containing the material with bacteriostatic activity in common fig leaf juice：Psoralen, benzaldehyde and Buddhist
The materials such as handss Citrus chachiensis Hort. lactone, it is with goodish Development volue and application prospect, but in real life production, most
Common fig leaf juice is all abandoned as waste, causes the significant wastage of resource, if developing its new purposes, can improve nature money
The value in source.
Determine according to Agricultural University Of Nanjing, in fig fruit, contain protein 4.3%, carbohydrate 74.3% is (wherein really
Sugar and glucose account for 15%-20%), and rich in trace element such as Ca, Mg, Zn, Na, Cu, B, containing 18 kinds of aminoacid, wherein have
10 kinds is aminoacid necessary to human body, 2 kinds of child's essential amino acids, aspartic acid content 0.475%-0.493%, Vc
Content be 2-3 times of mandarin orange, 20 times of Fructus Vitis viniferae, also containing it is substantial amounts of can adsorb various harmful substances in intestinal, purification intestinal,
Exclude the dietary fiber such as pectin of carcinogenic chemical, and the diastase of defying age, superoxide dismutase, esterase, ester
The materials such as fat enzyme, protease.The exploitation of Fructus Fici is concentrated mainly on fresh fruit storage and the shallower aspect such as edible, medicinal to its fruit
Value, the synthesis of fruit tree send out that research on utilization is less, therefore Fructus Fici is put into the category of anxious third generation fruit leaved for development, have compared with
Big researching value.
On market, existing Fructus Fici class product has health tea, fruit wine, oral liquid, fruit juice, buccal tablet, crispy slice, effervescent tablet, fruit
Piece, cookiess, health-caring capsule, extractum, fruit jam, dried fruitss, preserved fruit, canned food etc..Such as Chinese patent ZL201410203890.6 is disclosed
A kind of Fructus Fici effervescent tablet, is made up of the component of following weight portion：Fructus Fici crude polysaccharides 10-30 parts, vitamin C 5-
10 parts, filler 4-10 parts, acid compound 10-30 parts, alkali compoundss 10-50 parts, lubricant 0.5-5 parts, binding agent 1-4
Part；The filler is selected from any one in starch, Icing Sugar, Mannitol, dextrin, sucrose or arbitrarily several combinations；The acid
Property compound selected from citric acid, tartaric acid, fumaric acid, adipic acid, any one or arbitrarily several combinations in malic acid；It is described
Alkali compoundss are selected from sodium bicarbonate or/and sodium carbonate；The lubricant is selected from polyethylene glycol 6000 or/and micropowder silica gel；Institute
Binding agent is stated selected from dehydrated alcohol, polyvinylpyrrolidone, any one or arbitrarily several combinations in hydroxypropyl cellulose；Should
Fructus Fici effervescent tablet, fig polysaccharide purity are high, and content is big, is of high nutritive value, can give full play to its health-care effect.At present also
It is not directed to oral spray field.In view of Fructus Fici has significantly throat effect such as treatment laryngalgia, subduing swelling and detoxicating, can be by
Which develops into such functional health product.And existing oral spray is such as：Disclosed in Chinese patent ZL201010173269.1
A kind of oral spray, it mainly include water solublity Mentholum, fresh breath material, sweeting agent, xylitol, ethanol and go from
Sub- water, it is adaptable to refresh oneself when working, learning or fresh breath.Sweeting agent side effect in the formula is more and can cause fertilizer
The health problems such as fat, hypertension, hyperglycemia, and the spray curative effect is general, acts on single, and practicality is poor.Chinese patent
ZL201310209226.8 discloses a kind of horseradish oral spray, and the raw material of the oral spray has Wasabia japonic (Euterma Wasabi) extracting solution, solubilising
Agent, absorption enhancer, correctivess, simple syrup and ethanol solution surplus.Although the oral spray can help eliminate oral cavity and throat
Inflamed sites inflammation, suppresses antibacterial in the growth at pharyngolaryngitis erosion position, but Wasabia japonic (Euterma Wasabi) is the one kind found in the world today
Special edible health plant, is extremely precious seasoned food in the international market, and the expensive, market demand is very big.By
In Wasabia japonic (Euterma Wasabi) growth conditionss are special, it is limited where suitable growth plantation, Wasabia japonic (Euterma Wasabi) product is extremely rare, causes horseradish oral spray
It is expensive, it is impossible to popularity.Fructus Fici price is relatively low, and containing a large amount of in fig fruit and its leaf extract
Active component, including flavone, vitamin, trace element, amylase, lipase, protein, antifatigue anti senility asparagine
Acid, the antihypertensive Fructus Citri Sarcodactyliss lactone of anti-cancer and cancer-preventing, psoralen, benzaldehyde, polysaccharose substance etc., nutrition very abundant, tool
There are the action and efficacies such as nourishing the lung to arrest cough, invigorating the stomach and promoting bowel movement, subduing swelling and detoxicating, anti-inflammation detumescence, throat, and yield be high, cultivation management is easy,
Low price, economic worth are higher.Therefore, will have a wide range of applications if successfully developing Fructus Fici oral spray class product
Value.
The content of the invention
For existing market situation, prepared as raw material the invention provides a kind of with fig fruit extract freeze-drying powder
Fructus Fici oral spray.The Fructus Fici oral spray, with antibacterial, antiinflammatory, stop blooding, wet one's whistle, the multiple efficacies such as deodorize, make
With convenient, Modern human populations oral hygiene health demand is adapted to.
Present invention also offers a kind of preparation method of Fructus Fici oral spray, the method is simple to operate, it is easy to control,
Industrialized production is suitable to, with preferable promotional value.
A kind of Fructus Fici oral spray, it is in terms of 1000mL, composed of the following components：
Fig fruit extract freeze-drying powder 50g-150g；
Preservative 2g-6g；
Absorption enhancer 40g-80g；
Balance of deionized water.
In above-mentioned formula, the preservative selects fig leaf extract, and its main component is psoralen, can conduct
A kind of new natural antisepsis fresh-keeping agent, with good antibacterial antiseptic effect.
The absorption enhancer is made up of clinopodium grass saponin and cholate, wherein, the quality of clinopodium grass saponin and cholate
Than being preferably 3:1.Clinopodium grass saponin and cholate have preferable potentiation between the two, and clinopodium grass saponin is natural as one kind
Nonionic surfactant, small colloidal particle can be formed in water, by formed micelle effect Fructus Fici is carried
In taking thing, flavone, polysaccharide and psoralen isoreactivity composition are attached together, and increase the permeability of iuntercellular water solublity passage,
Promote the absorption of water-soluble substanceses；And the cholate of low concentration with aquation and can extract intercellular lipid, carry so as to increased
Diffusion of the thing in iuntercellular aqueous channels is taken, while cholate, can change many by affecting the activity of enzyme as enzyme inhibitor
The different mechanism such as peptide, protein conformation maintains stablizing for medicine, can be bright with surfactant clinopodium grass saponin compounding by which
The absorption of aobvious increase Fructus Fici oral spray effective ingredient.Described cholate selects commercially available prod, can select glycocholic acid
In sodium, glycochenodeoxycholate sodium, sodium taurocholate, Irish moss (chondrux) sodium, NaTDC etc. one or two with
On.
In order to reach more preferable invention effect, it is preferable that described Fructus Fici oral spray, in terms of 1000mL, by following
Component is constituted：
Fig fruit extract freeze-drying powder 80g-150g；
Preservative 2g-5g；
Absorption enhancer 40g-72g；
Balance of deionized water.
Described fig fruit extract freeze-drying powder can be using existing fig fruit extract freeze-drying powder (as commercially available
Product) or using the fig fruit extract freeze-drying powder of prior art preparation, it is preferred to use following preparation method is prepared into
The fig fruit extract freeze-drying powder for arriving：
The preparation method of described fig fruit extract freeze-drying powder, comprises the following steps：
Fig fruit obtains fig fruit powder (preferably crossing 60 mesh sieves) Jing after clean, lyophilizing and crushing；Will be without flower
Fruits powder carries out Subcritical water chromotagraphy by extracting solution of subcritical water, and extraction time is 10min-40min；Subcritical hydraulic pressure
Power is 4MPa-7MPa, and temperature is 120 DEG C -180 DEG C, and flow velocity is 5L/h-10L/h；The concentrated drying of extract for obtaining is (preferably
In 55 DEG C of vacuum distillation concentrate dryings), lyophilizing, obtain containing the multicomponents such as fig polysaccharide, flavone and cellulose activity nothing
Flowers and fruits fruit extract lyophilized powder.
Described fig leaf extract can adopt existing fig leaf extract (such as commercially available prod) or using existing
The fig leaf extract for having technology to prepare, described fig leaf extract preferably select dried fig leaf extract
Such as fig leaf extract lyophilized powder, is easy to prepare spray, is further preferably prepared using following preparation method
Fig leaf extract：
The preparation method of described fig leaf extract, comprises the following steps：
Common fig leaf juice obtains common fig leaf juice powder Jing after clean, lyophilizing and crushing；By common fig leaf juice powder with subcritical water
Subcritical water chromotagraphy is carried out for extracting solution, extraction time is 20min；Subcritical water pressure is 5MPa, and temperature is 130 DEG C, flow velocity
For 8L/h；By the extract for obtaining concentrated drying (preferably in 55 DEG C of vacuum distillation concentrate dryings) lyophilizing afterwards, Fructus Psoraleae is obtained
The higher fig leaf extract of cellulose content.
Described clinopodium grass saponin can adopt existing clinopodium grass saponin (such as commercially available prod) or adopt prior art system
Standby clinopodium grass saponin, described clinopodium grass saponin preferably select such as clinopodium grass saponin lyophilizing of dried clinopodium grass saponin
Powder, is easy to prepare spray, it is preferred to use the clinopodium grass saponin that following preparation method is prepared：
The preparation method of described clinopodium grass saponin, comprises the following steps：
Clinopodium grass is put into into supersound extraction 30min in the ethanol water of mass percentage concentration 80%, is filtrated to get once
Filtrate, filtering residue supersound extraction 30min in the ethanol water of mass percentage concentration 80% are filtrated to get secondary filtrate, merge
First-time filtrate and secondary filtrate obtain filtrate, and concentrating filter liquor (preferably in 30 DEG C of concentrating under reduced pressure), lyophilizing obtain higher degree
Clinopodium grass saponin extract.
The preparation method of described Fructus Fici oral spray, comprises the following steps：
(1) clinopodium grass saponin is mixed homogeneously into the accelerator that is absorbed with cholate；
(2) by absorption enhancer, preservative and appropriate amount of deionized water mix homogeneously, mixed solution A is obtained；
(3) in mixed solution A fig fruit extract freeze-drying powder, mix homogeneously is added to obtain mixed solution B；
(4) add deionized water in mixed solution B and be settled to 1000mL, obtain Fructus Fici mouthspray Jing after filtering antibacterial
Agent.
When preparing Fructus Fici oral spray, active component fig fruit extract freeze-drying powder is added and is prepared in advance
Containing absorption enhancer, the mixed solution A of preservative in, relative to traditional mixed once method, can preferably play this
Effect of invention absorption enhancer.
Obtained Fructus Fici oral spray is filled in aerosol apparatus, that is, Fructus Fici oral spray product is obtained.
In sum, Fructus Fici oral spray of the present invention is a kind of with various natural activity components, fungistatic effect
Significantly, with nourishing the lung to arrest cough, clearing away heat and moistening the bowels, the oral spray of removing toxic substances and promoting subsidence of swelling；The preparation of above recipe ingredient can be according to reality
Needs are adjusted.
Subcritical state is a kind of form relative to critical state and supercriticality.The pressure of control appropriateness, by water
100 DEG C are heated to the high temperature below 374 DEG C of upper critical temperature, water body stills remain in liquid condition, and its polarity can be with temperature
Degree changes and changes, and this water is referred to as subcritical water.Subcritical water has bigger difference in nature with the water under normal temperature and pressure, can
To adjust the polarity of subcritical water by controlling temperature and pressure, so as to reach the purpose of selective extraction target component, adopt
This new extractive technique of subcritical water extraction, can largely extract target component within a short period of time, and the technique has
Effective percentage height, cycle is short, advantages of environment protection, are with a wide range of applications in terms of active components of plants is extracted.
Clinopodium grass, another name：Herba Clinopodii Polycephali, Herba leucadis zeylanicae, Herba Clinopodii Polycephali, landing Flos Mume, nine towers are careless, red nine towers flower, wild Herba mesonae chinensiss, are
The herb of Labiatae (Labiatae) plant clinopodium grass ClinopodiumchinensisO.Kze..
The fresh fig fruit of fig fruit of the present invention and the preferred high-quality of common fig leaf juice and high-quality common fig leaf juice.
Beneficial effect of the present invention is：
1st, Ficus medicine-food two-purpose resource, has no toxic side effect, and by the use of common fig leaf juice extract as preservative,
Good antiseptic effect can be played, recycling for common fig leaf juice garbage can be realized again, the utilization of common fig leaf juice is improve
Rate.
2nd, compared with existing oral spray, antibiotic and ethanol is not contained in oral spray of the present invention, will not be caused
The generation of the bacterial drug resistance that antibiotic is caused, and be equally applicable for ethanol or alcohol sensible crowd.With existing product
Condition is more less than the adjuvant added in the present invention, can largely retain the unique fragrant of Fructus Fici.
3rd, in inventive formulation, main component is fig fruit extract, and its extract effective ingredient includes flavone, many
Sugar, aminoacid and trace element etc., the effects such as with excellent defying age, anticancer, anti-inflammation detumescence, throat.Common fig leaf juice
Extract high enrichment flavone compound and Coumarinses lactone nutrient, with good antiradical activities, have
Significantly antibacterial, antiinflammatory and antivirus action, as natural antibiotic antiseptic, can extend the storage of Fructus Fici mouthspray
Time.
4th, in inventive formulation, clinopodium grass belongs to Clinopodium, and the chemical composition of Clinopodium plant is extremely complex, containing Huang
The compounds such as ketone, saponinss, organic acid, the fragrant same clan, triterpeness, steroid, wherein saponins compound are planted for the category
The main active of thing, clinopodium grass saponin contain lipophilic triterpeness aglycon and the sugar chain compared with strongly hydrophilic, can be with nothing
Flowers and fruits extract combines to form micelle so as to which dissolubility in a solvent increases, with good solubilized absorbefacient effect.Wind
The careless saponin of wheel can form small colloidal particle, by shape in water as a kind of natural nonionic surfactant
Flavone, polysaccharide and psoralen isoreactivity composition in Fructus Fici extract are attached together into micelle effect, increase cell
Between water solublity passage permeability, promote water-soluble substanceses absorption；And the cholate of low concentration with aquation and can be extracted thin
Intercellular lipid, so as to increased diffusion of the extract in iuntercellular aqueous channels, while cholate can lead to as enzyme inhibitor
Crossing affects the activity of enzyme, changes the different mechanism such as polypeptide, protein conformation and maintains stablizing for medicine, by itself and surfactant
Clinopodium grass saponin compounding can significantly increase the absorption of Fructus Fici oral spray effective ingredient.
5th, all components in inventive formulation are the high composition of nontoxic, non-stimulated, security performance, and most of composition is
Extracted form natural plant active component, can be with safe to use.
6th, with regard to health fig product, current on the market mainly with moistening and cleaning throat as health care tablet, buccal tablet, granule,
Based on the dosage forms such as teabag, cream, mouthspray dosage form has easy to carry, takes the advantage of simple and fast, while the product was both
Protection throat can be played, the effect of fresh breath, the effects such as have health and beauty, prophylactic treatment oral cavity FAQs again.It is special
Laryngopharynx swelling and pain and prevention upper respiratory tract infection Shi Yongyu not be treated.
Specific embodiment
With reference to embodiments the present invention is described in further detail.
Embodiment 1
The preparation method of Fructus Fici oral spray, comprises the following steps：
1. the preparation of fig fruit extract freeze-drying powder：
(1.1) high-quality fresh fig fruit is selected, after rinsing well, lyophilizing in freeze dryer is put into；
(1.2) fig fruit after lyophilizing is shredded, is put into pulverizer and is ground into powder, cross 60 mesh sieves；
(1.3) dry fig fruit powder 120g is weighed, rustless steel is put into and is extracted in kettle, with subcritical water as extracting
Liquid carries out Subcritical water chromotagraphy to the powder, and extraction time is 10min；Rustless steel extract kettle in subcritical water pressure be
4MPa, temperature are 120 DEG C, and flow velocity is 5L/h；Obtain extract；
(1.4) said extracted thing is obtained containing fig polysaccharide, flavone and fiber in 55 DEG C of vacuum distillation concentrate dryings
The multicomponent activity extract of element etc., and lyophilizing is obtained fig fruit extract freeze-drying powder in placing it in freeze dryer.
2. the preparation of Fructus Fici spray：
A. 45g clinopodium grass saponin (purchased from bright biological development corporation, Ltd. of Baoji side) and 15g Irish moss (chondrux)s are taken
Sodium (purchased from Shanghai Yuan Ye bio tech ltd), mix homogeneously are absorbed accelerator 60g.
B. fig leaf extract lyophilized powder (purchased from Xi'an Bioisystech Co., Ltd of Tianrui) 6g and appropriate deionization are taken
Water is mixed and stirred in 250mL beakers uniformly, then which is uniformly mixed to prepare mixed solution A with 60g absorption enhancers.
C. 70g fig fruit extract freeze-drying powder mix homogeneously is added in mixed solution A, obtain mixed solution B.
D. add deionized water in mixed solution B and be settled to 1000mL, Fructus Fici mouth is obtained Jing after biofilter is filtered
Chamber spray, obtained spray is filled in aerosol apparatus, that is, Fructus Fici oral spray product is obtained.
Embodiment 2
The preparation method of Fructus Fici oral spray, comprises the following steps：
1. the preparation of fig fruit extract freeze-drying powder：
(1.1) high-quality fresh fig fruit is selected, after rinsing well, lyophilizing in freeze dryer is put into；
(1.2) fig fruit after lyophilizing is shredded, is put into pulverizer and is ground into powder, cross 60 mesh sieves；
(1.3) dry fig fruit powder 140g is weighed, rustless steel is put into and is extracted in kettle, with subcritical water as extracting
Liquid carries out Subcritical water chromotagraphy to the powder, and extraction time is 20min；Rustless steel extract kettle in subcritical water pressure be
5MPa, temperature are 130 DEG C, and flow velocity is 7L/h；Obtain extract；
(1.4) said extracted thing is obtained containing fig polysaccharide, flavone and fiber in 55 DEG C of vacuum distillation concentrate dryings
The multicomponent activity extract of element etc., and lyophilizing is obtained fig fruit extract freeze-drying powder in placing it in freeze dryer.
2. the preparation of fig leaf extract：
(2.1) common fig leaf juice of high-quality is selected, after rinsing well, lyophilizing in freeze dryer is put into；
(2.2) common fig leaf juice after lyophilizing is put into into pulverizer and is ground into powder, cross 60 mesh sieves；
(2.3) the common fig leaf juice powder 50g of appropriate drying is weighed, rustless steel is put into and is extracted in kettle, with subcritical water be
Extracting solution carries out Subcritical water chromotagraphy to the powder, and extraction time is 20min；Rustless steel extract kettle in subcritical water pressure be
5MPa, temperature are 130 DEG C, and flow velocity is 8L/h；Obtain fig leaf extract；
(2.4) fig leaf extract is obtained into the extract containing psoralen in 55 DEG C of vacuum distillation concentrate dryings,
And in placing it in freeze dryer, lyophilizing is obtained fig leaf extract lyophilized powder, stores for future use.
3. the preparation of clinopodium grass saponin：
(3.1) weigh clinopodium grass coarse powder 100g to be placed in ground conical flask with stopper, add 80% ethanol of mass percentage concentration
Aqueous solution 1000mL, ultrasound carry 30min, filter to get filtrate, and filtering residue is added with 80% ethanol water of 1000mL mass percentage concentration,
Repeat supersound extraction 30min, filter, merge filtrate twice, obtain filtrate；
(3.2) filtrate is concentrated under reduced pressure to give into clinopodium grass saponin extract at 30 DEG C, and is frozen in placing it in freeze dryer
It is drying to obtain clinopodium grass saponin lyophilized powder, store for future use.
4. the preparation of Fructus Fici spray：
A. 45g clinopodium grass saponin lyophilized powders and 15g Irish moss (chondrux) sodium are taken, mix homogeneously is absorbed accelerator
60g。
B. take fig leaf extract lyophilized powder 4g to be mixed and stirred in 250mL beakers uniformly with appropriate amount of deionized water,
Which is uniformly mixed to prepare into mixed solution A with 60g absorption enhancers again.
C. 80g fig fruit extract freeze-drying powder mix homogeneously is added in mixed solution A, obtain mixed solution B.
D. add deionized water in mixed solution B and be settled to 1000mL, Fructus Fici mouth is obtained Jing after biofilter is filtered
Chamber spray, obtained spray is filled in aerosol apparatus, that is, Fructus Fici oral spray product is obtained.
Embodiment 3
The preparation method of Fructus Fici oral spray, comprises the following steps：
1. the preparation of fig fruit extract freeze-drying powder：
(1.1) high-quality fresh fig fruit is selected, after rinsing well, lyophilizing in freeze dryer is put into；
(1.2) fig fruit after lyophilizing is shredded, is put into pulverizer and is ground into powder, cross 60 mesh sieves；
(1.3) dry fig fruit powder 180g is weighed, rustless steel is put into and is extracted in kettle, with subcritical water as extracting
Liquid carries out Subcritical water chromotagraphy to the powder, and extraction time is 25min；Rustless steel extract kettle in subcritical water pressure be
6MPa, temperature are 150 DEG C, and flow velocity is 8L/h；Obtain extract；
(1.4) said extracted thing is obtained containing fig polysaccharide, flavone and fiber in 55 DEG C of vacuum distillation concentrate dryings
The multicomponent activity extract of element etc., and lyophilizing is obtained fig fruit extract freeze-drying powder in placing it in freeze dryer.
Clinopodium grass saponin lyophilized powder is with fig leaf extract lyophilized powder with embodiment 2.
2. the preparation of Fructus Fici spray：
A. 54g clinopodium grass saponin lyophilized powders and 18g Irish moss (chondrux) sodium are taken, mix homogeneously is absorbed accelerator
72g。
B. take fig leaf extract lyophilized powder 2g to be mixed and stirred in 250mL beakers uniformly with appropriate amount of deionized water,
Which is uniformly mixed to prepare into mixed solution A with 72g absorption enhancers again.
C. 120g fig fruit extract freeze-drying powder mix homogeneously is added in mixed solution A, obtain mixed solution B.
D. add deionized water in mixed solution B and be settled to 1000mL, Fructus Fici mouth is obtained Jing after biofilter is filtered
Chamber spray, obtained spray is filled in aerosol apparatus, that is, Fructus Fici oral spray product is obtained.
Embodiment 4
The preparation method of Fructus Fici oral spray, comprises the following steps：
1. the preparation of fig fruit extract freeze-drying powder：
(1.1) high-quality fresh fig fruit is selected, after rinsing well, lyophilizing in freeze dryer is put into；
(1.2) fig fruit after lyophilizing is shredded, is put into pulverizer and is ground into powder, cross 60 mesh sieves；
(1.3) dry fig fruit powder 200g is weighed, rustless steel is put into and is extracted in kettle, with subcritical water as extracting
Liquid carries out Subcritical water chromotagraphy to the powder, and extraction time is 30min；Rustless steel extract kettle in subcritical water pressure be
6MPa, temperature are 160 DEG C, and flow velocity is 8L/h；Obtain extract；
(1.4) said extracted thing is obtained containing fig polysaccharide, flavone and fiber in 55 DEG C of vacuum distillation concentrate dryings
The multicomponent activity extract of element etc., and lyophilizing is obtained fig fruit extract freeze-drying powder in placing it in freeze dryer.
Clinopodium grass saponin lyophilized powder is with fig leaf extract lyophilized powder with embodiment 2.
2. the preparation of Fructus Fici spray：
A. 30g clinopodium grass saponin lyophilized powders and 10g Irish moss (chondrux) sodium are taken, mix homogeneously is absorbed accelerator
40g。
B. take fig leaf extract lyophilized powder 5g to be mixed and stirred in 250mL beakers uniformly with appropriate amount of deionized water,
Which is uniformly mixed to prepare into mixed solution A with 40g absorption enhancers again.
C. 150g fig fruit extract freeze-drying powder mix homogeneously is added in mixed solution A, obtain mixed solution B.
D. add deionized water in mixed solution B and be settled to 1000mL, Fructus Fici mouth is obtained Jing after biofilter is filtered
Chamber spray, obtained spray is filled in aerosol apparatus, that is, Fructus Fici oral spray product is obtained.
Embodiment 5
The preparation method of Fructus Fici oral spray, comprises the following steps：
1. the preparation of fig fruit extract freeze-drying powder：
(1.1) high-quality fresh fig fruit is selected, after rinsing well, lyophilizing in freeze dryer is put into；
(1.2) fig fruit after lyophilizing is shredded, is put into pulverizer and is ground into powder, cross 60 mesh sieves；
(1.3) dry fig fruit powder 100g is weighed, rustless steel is put into and is extracted in kettle, with subcritical water as extracting
Liquid carries out Subcritical water chromotagraphy to the powder, and extraction time is 40min；Rustless steel extract kettle in subcritical water pressure be
7MPa, temperature are 180 DEG C, and flow velocity is 10L/h；Obtain extract；
(1.4) said extracted thing is obtained containing fig polysaccharide, flavone and fiber in 55 DEG C of vacuum distillation concentrate dryings
The multicomponent activity extract of element etc., and lyophilizing is obtained fig fruit extract freeze-drying powder in placing it in freeze dryer.
Clinopodium grass saponin is with fig leaf extract lyophilized powder with embodiment 1.
2. the preparation of Fructus Fici spray：
A. 60g clinopodium grass saponin and 20g Irish moss (chondrux) sodium are taken, mix homogeneously is absorbed accelerator 80g.
B. take fig leaf extract lyophilized powder 2g to be mixed and stirred in 250mL beakers uniformly with appropriate amount of deionized water,
Which is uniformly mixed to prepare into mixed solution A with 80g absorption enhancers again.
C. 50g fig fruit extract freeze-drying powder mix homogeneously is added in mixed solution A, obtain mixed solution B.
D. add deionized water in mixed solution B and be settled to 1000mL, Fructus Fici mouth is obtained Jing after biofilter is filtered
Chamber spray, obtained spray is filled in aerosol apparatus, that is, Fructus Fici oral spray product is obtained.
Comparative example 1 (using high concentration cholate as single absorption enhancer)
Fig fruit extract freeze-drying powder is with fig leaf extract lyophilized powder with embodiment 1.
The preparation of Fructus Fici spray：
By 6g fig leaf extract lyophilized powders, 70g fig fruits extract freeze-drying powder and 60g absorption enhancer cattle sulphurs
Chenodeoxy cholic acid sodium, uses appropriate amount of deionized water mix homogeneously, addition deionized water to be settled to 1000mL, and Jing biofilters are filtered
After must contrast and use Fructus Fici oral spray.
Comparative example 2 (using clinopodium grass saponin as single absorption enhancer)
Fig fruit extract freeze-drying powder, clinopodium grass saponin lyophilized powder and the same embodiment of fig leaf extract lyophilized powder
1。
The preparation of Fructus Fici spray：
By 6g fig leaf extract lyophilized powders, 70g fig fruits extract freeze-drying powder and 60g absorption enhancer wind wheels
Careless saponin lyophilized powder appropriate amount of deionized water mix homogeneously, addition deionized water are settled to 1000mL, and Jing biofilters are filtered
After must contrast and use Fructus Fici oral spray.
Testing example 1
This testing example determines the safety of the Fructus Fici oral spray of the present invention.
The Fructus Fici oral spray of embodiment 1-5 is carried out into gavage experiment to mice (C57 mices, 18-22g), daily
0.5mL, continuous 30 days, has no that mice Novel presentation, absolute organ coefficient and relative organ coefficient are showed no significant change.
Testing example 2
This testing example determines the anti-microbial property of the Fructus Fici oral spray of the present invention.
By staphylococcus aureuses, (purchased from ATCC, 29213) in LB culture medium, (tryptone 10g/L, yeast are extracted article No.
Thing 5g/L, Sodium Chloride 10g/L) in cultivate to logarithmic (log) phase, adjust cell concentration to 10 with LB culture medium6Individual/L, used as containing gold
The bacterium solution of Staphylococcus aureus.
Fructus Fici oral spray, the Fructus Fici mouth of comparative example 1-2 of embodiment 1-5 is separately added in the bacterium solution of 10m
The each 0.5mL of chamber spray, at 37 DEG C cultivate 6 hours, obtain it is antibacterial after sample.
It is according to method specified in GB4789.10-2010 (inspection of food microbiological examination staphylococcus aureuses), right
It is above-mentioned it is antibacterial after sample carry out colony counting method viable bacteria body number detection, as a result as shown in table 1.
Table 1
Visible according to the data of table 1, the Fructus Fici oral spray of the present invention has effective fungistatic effect and antibacterial effect
Fruit significantly, also, contains Fructus Fici extract lyophilized powder, the 2g/L- of 80g/L-150g/L in preferred Fructus Fici oral spray
The fungistatic effect that the preservative of 5g/L, the absorption enhancer of 40g/L-72g/L have becomes apparent from.
Testing example 3
The present embodiment determines the effect of the treatment oral cavity and throat inflammation of the Fructus Fici oral spray of the present invention.
Cavia porcelluss are anesthetized with ether, a cotton pellet is placed in into glass tubing one end (being allowed to concordant with the mouth of pipe) of a diameter of 5mm, then
The phenol solution of 90% volume is dipped in in glass pipe close cotton balls one end, calcination Cavia porcelluss left surface cheek 60s is observed after 24h, Cavia porcelluss oral cavity
Occur the pharyngolaryngitis of diameter 5mm on mucosa, that is, obtain oral cavity and throat inflammation animal model.
The Fructus Fici oral spray of embodiment 1-5, the Fructus Fici oral cavity of comparative example 1-2 are dipped respectively with Disinfectant absorbent cotton to spray
The each 0.3mL of mist agent, is placed on 5min at Cavia porcelluss oral cavity and throat inflammation, and the daily morning and evening is each once.
At the 3rd, 5,7 days respectively with digital picture head record Cavia porcelluss oral cavity and throat inflammation situation, for observing mice pharyngolaryngitis
Healing situation.The 2h after last 1 medication of each cycle, is evaluated after Cavia porcelluss oral cavity and throat inflammation degree by judgment criteria, puts to death globefish
Mus, remove oral cavity and throat local, 100g/L formalin fixes, paraffin embedding, section, microscopy, the pharynx of observation each group Cavia porcelluss oral cavity
Larynx tissue morphology situation.
Pharyngolaryngitis degree judgment criteria：" O ", without pharyngolaryngitis, oral mucosa is normal；" I " has pharyngolaryngitis, and throat surface is without bright
Aobvious redness phenomenon；" II " has pharyngolaryngitis, and there are very thin secretions on throat surface, around without substantially red and swollen；" III " has pharyngolaryngitis, pharynx
Larynx surface secretions are more, and surrounding is with mild inflammatory swelling；" IV " has pharyngolaryngitis, and throat surface secretions are more, surrounding
With obvious inflammatory hyperemia swelling phenomenon.
Symptoms of the guinea pig model oral cavity and throat in different cycles are as shown in table 2.
Table 2
Visible according to the data of table 2, the Fructus Fici oral spray of the present invention has good treatment oral cavity and throat inflammation
Effect and effect is significant, also, contain the Fructus Fici extract lyophilizing of 80g/L-150g/L in preferred Fructus Fici oral spray
In the case of powder, the preservative of 2g/L-5g/L, the absorption enhancer of 40g/L-72g/L, with more significantly therapeutic effect.
With in comparative example 1 using high concentration cholate as single absorption enhancer Fructus Fici oral spray, contrast
Fructus Fici oral spray in example 2 using clinopodium grass saponin as single absorption enhancer is compared, and the present invention is using by wind wheel
The Fructus Fici oral spray oral bacteriostasis of the compounding absorption enhancer of careless saponin and cholate composition, anti-inflammation detumescence effect are more
Significantly, can nourishing the lung to arrest cough, clearing away heat and moistening the bowels, removing toxic substances and promoting subsidence of swelling, with higher popularization productive value.
The preferred embodiment of the present invention described in detail above, but, the present invention is not limited in above-mentioned embodiment
Detail, the present invention range of the technology design in, various simple variants can be carried out to technical scheme.
In inventive formulation, the change of parameter has no effect on the essential effect of product.The change of parameter in preparation method of the present invention
Change has no effect on the preparation of product and nor affects on the essential effect of product, thus in preparation method of the present invention arbitrary parameter combination
The preparation of product is capable of achieving.Will not be described here.
Claims (9)
1. a kind of Fructus Fici oral spray, it is characterised in that in terms of 1000mL, composed of the following components：
Fig fruit extract freeze-drying powder 50g-150g；
Preservative 2g-6g；
Absorption enhancer 40g-80g；
Balance of deionized water；
Described absorption enhancer is made up of clinopodium grass saponin and cholate.
2. Fructus Fici oral spray according to claim 1, it is characterised in that in terms of 1000mL, by following components group
Into：
Fig fruit extract freeze-drying powder 80g-150g；
Preservative 2g-5g；
Absorption enhancer 40g-72g；
Balance of deionized water.
3. Fructus Fici oral spray according to claim 1, it is characterised in that clinopodium grass in described absorption enhancer
Saponin is 3 with the mass ratio of cholate:1.
4. the Fructus Fici oral spray according to claim 1 or 3, it is characterised in that the system of described clinopodium grass saponin
Preparation Method, comprises the following steps：
Clinopodium grass is put into into supersound extraction 30min in the ethanol water of mass percentage concentration 80%, first-time filtrate is filtrated to get,
Filtering residue supersound extraction 30min in the ethanol water of mass percentage concentration 80%, is filtrated to get secondary filtrate, and merging is once filtered
Liquid and secondary filtrate obtain filtrate, and concentrating filter liquor, lyophilizing obtain clinopodium grass saponin extract.
5. Fructus Fici oral spray according to claim 1 and 2, it is characterised in that described preservative is Fructus Fici
Leaf extract.
6. Fructus Fici oral spray according to claim 5, it is characterised in that the system of described fig leaf extract
Preparation Method, comprises the following steps：
Common fig leaf juice obtains common fig leaf juice powder Jing after clean, lyophilizing and crushing；By common fig leaf juice powder with subcritical water as carrying
Taking liquid carries out Subcritical water chromotagraphy, and extraction time is 20min；Subcritical water pressure is 5MPa, and temperature is 130 DEG C, and flow velocity is 8L/
h；The concentrated drying of extract that obtains, lyophilizing, obtain fig leaf extract.
7. Fructus Fici oral spray according to claim 1 and 2, it is characterised in that described fig fruit is extracted
The preparation method of thing lyophilized powder, comprises the following steps：
Fig fruit obtains fig fruit powder Jing after clean, lyophilizing and crushing；By fig fruit powder with subcritical
Water carries out Subcritical water chromotagraphy for extracting solution, and extraction time is 10min-40min；Subcritical water pressure be 4MPa-7MPa, temperature
For 120 DEG C -180 DEG C, flow velocity is 5L/h-10L/h；The concentrated drying of extract that obtains, lyophilizing, obtain fig fruit extraction
Thing lyophilized powder.
8. Fructus Fici oral spray according to claim 1, it is characterised in that described described cholate is from sweet
One kind or two in ammonia sodium cholate, glycochenodeoxycholate sodium, sodium taurocholate, Irish moss (chondrux) sodium, NaTDC
More than kind.
9. the preparation method of the Fructus Fici oral spray according to any one of claim 1-8, it is characterised in that include with
Lower step：
(1) clinopodium grass saponin is mixed homogeneously into the accelerator that is absorbed with cholate；
(2) by absorption enhancer, preservative and appropriate amount of deionized water mix homogeneously, mixed solution A is obtained；
(3) in mixed solution A fig fruit extract freeze-drying powder, mix homogeneously is added to obtain mixed solution B；
(4) add deionized water in mixed solution B and be settled to 1000mL, obtain Fructus Fici oral spray Jing after filtering antibacterial.
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| CN108813465A (en) * | 2018-07-03 | 2018-11-16 | 浙江省林业科学研究院 | A kind of fig function chewable tablets and preparation method thereof |
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