CN105770658A - Traditional Chinese medicine preparation for treating oral disease - Google Patents
Traditional Chinese medicine preparation for treating oral disease Download PDFInfo
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- CN105770658A CN105770658A CN201610326947.0A CN201610326947A CN105770658A CN 105770658 A CN105770658 A CN 105770658A CN 201610326947 A CN201610326947 A CN 201610326947A CN 105770658 A CN105770658 A CN 105770658A
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- chinese medicine
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- 239000003814 drug Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 208000025157 Oral disease Diseases 0.000 title claims abstract description 26
- 208000030194 mouth disease Diseases 0.000 title claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 210000000582 semen Anatomy 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000007921 spray Substances 0.000 claims abstract description 4
- 241000628997 Flos Species 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 12
- 239000000047 product Substances 0.000 claims description 8
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 8
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 6
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 6
- -1 after fill Substances 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229940069338 potassium sorbate Drugs 0.000 claims description 6
- 235000010241 potassium sorbate Nutrition 0.000 claims description 6
- 239000004302 potassium sorbate Substances 0.000 claims description 6
- 208000007117 Oral Ulcer Diseases 0.000 claims description 5
- 208000002399 aphthous stomatitis Diseases 0.000 claims description 5
- 210000000214 mouth Anatomy 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 206010011224 Cough Diseases 0.000 claims description 3
- 208000007565 gingivitis Diseases 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 201000001245 periodontitis Diseases 0.000 claims description 3
- 206010044008 tonsillitis Diseases 0.000 claims description 3
- 230000037213 diet Effects 0.000 claims description 2
- 235000005911 diet Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 8
- 241000411851 herbal medicine Species 0.000 abstract description 3
- 240000002234 Allium sativum Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 244000035851 Chrysanthemum leucanthemum Species 0.000 abstract 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract 1
- 241001226187 Cyrtomium fortunei Species 0.000 abstract 1
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 235000013719 Houttuynia cordata Nutrition 0.000 abstract 1
- 244000292697 Polygonum aviculare Species 0.000 abstract 1
- 235000006386 Polygonum aviculare Nutrition 0.000 abstract 1
- 241000219295 Portulaca Species 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 235000008406 SarachaNachtschatten Nutrition 0.000 abstract 1
- 235000004790 Solanum aculeatissimum Nutrition 0.000 abstract 1
- 235000008424 Solanum demissum Nutrition 0.000 abstract 1
- 235000018253 Solanum ferox Nutrition 0.000 abstract 1
- 235000000208 Solanum incanum Nutrition 0.000 abstract 1
- 240000002915 Solanum macrocarpon Species 0.000 abstract 1
- 235000013131 Solanum macrocarpon Nutrition 0.000 abstract 1
- 235000009869 Solanum phureja Nutrition 0.000 abstract 1
- 235000000341 Solanum ptychanthum Nutrition 0.000 abstract 1
- 235000017622 Solanum xanthocarpum Nutrition 0.000 abstract 1
- 241000607059 Solidago Species 0.000 abstract 1
- 240000001519 Verbena officinalis Species 0.000 abstract 1
- 235000018718 Verbena officinalis Nutrition 0.000 abstract 1
- 235000004611 garlic Nutrition 0.000 abstract 1
- 238000001914 filtration Methods 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
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- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
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- 206010072170 Skin wound Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 208000032625 disorder of ear Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
Classifications
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- Health & Medical Sciences (AREA)
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating an oral disease. The traditional Chinese medicine preparation is prepared from the following raw materials: vervain, garlic, radix achyranthis bidentatae, radix stemonae, portulaca, fig, radix angelicae, perfoliote knotweed herb, radix sophorae flavescentis, polygonum cuspidatum, wild chrysanthemum flowers, houttuynia cordata, honeysuckle, radix sophorae tonkinensis, cortex mori radicis, nightshade, semen armeniacae amarae, solidago and cyrtomium fortunei. The traditional Chinese medicine preparation is a water spray extracted from pure Chinese herbal medicines, and is convenient to carry and use, free of a side effect, safe, reliable and good in curative effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation treating oral disease, belong to field of medicaments.
Background technology
Human oral cavity, tooth, throat, ear disease are general commonly encountered diseases, it is common that antibacterial infects and virus causes, if treating not in time, not only affecting normal operation, also can be related to life safety.Therapeutic Method common with hospital in the market is antiinflammatory of having an injection, or takes Western medicine.The method, it is necessary to the time to diagnose the illness and Western medicine have side effect, even if taking SHANGLIAOHOUFENG SAN powder, larynx of easily choking is felt bad, and changes into and pastes series products with Yi Kou, is easily generated allergy, and effect is not necessarily reliable.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation treating oral disease, the water preparation for pure Chinese herbal medicine extracting is sprayed, and carries, easy to use, and have no side effect safe and reliable, good effect.
A kind of Chinese medicine preparation treating oral disease, is made up of the raw material of Chinese medicine of following masses number: Herba Verbenae 8-30 part, Bulbus Allii 2-10 part, Radix Achyranthis Bidentatae 0.5-15 part, Radix Stemonae 10-50 part, MAZHIXIAN 8-30 part, Fructus Fici 6-25 part, Radix Angelicae Dahuricae 1-10 part, Herba Polygoni cymosi 5-25 part, Radix Sophorae Flavescentis 6-30 part, Rhizoma Polygoni Cuspidati 3-10 part, Flos Chrysanthemi Indici 0.5-10 part, Herba Houttuyniae 3-20 part, Flos Lonicerae 0.8-40 part, Radix Sophorae Tonkinensis 0.5-0.8 part, Cortex Mori 0.7-8 part, Herba Solani Nigri 0.5-18 part, Semen Armeniacae Amarum 0.5-8 part, Herba Solidaginis 0.5-30 part, Rhizoma Osmundae 0.6-10 part.
A kind of Chinese medicine preparation treating oral disease, preparation technology is: be placed in extraction pot by above-mentioned each raw material, add 100-200 part distilled water, 80-90 DEG C heating extraction 40-80 minute, filter, filtrate is concentrated into the 1/2-2/3 of original volume, fine straining again, add 0.1-0.5 part Borneolum Syntheticum and 0.1-0.5 part potassium sorbate, after fill, product.
A kind of Chinese medicine preparation treating oral disease, using method is: direct-injection or pour oral cavity or throat, spray 3-4 time into.
A kind of Chinese medicine preparation treating oral disease, treatment oral ulcer or when periodontitis, gingivitis, it is contained in the mouth under 10-15 minute posterior phraynx or spue,.
A kind of Chinese medicine preparation treating oral disease, during treatment pharyngolaryngitis, tonsillitis, cough, point several times to be swallowed, diet after half an hour.
The present invention can treat the diseases such as oral ulcer, periodontitis, gingivitis, pharyngolaryngitis, tonsillitis, otitis media, cough, it is made up of pure Chinese herbal medicine, nontoxic, have no side effect, safe and reliable, curative effect is fast, effective, aboundresources, cost are low, profit is big, making is simple, especially environmentally safe, nuisanceless, it is genuine green product, for solving the difficulty and high cost of getting medical, the high cost of getting medical treatment, plays major and immediate significance.
Specific embodiment:
Embodiment 1:
A kind of Chinese medicine preparation treating oral disease, is made up of the raw material of Chinese medicine of following masses number: Herba Verbenae 8 parts, 2 parts of Bulbus Allii, Radix Achyranthis Bidentatae 0.5 part, the Radix Stemonae 10 parts, MAZHIXIAN 8 parts, Fructus Fici 6 parts, the Radix Angelicae Dahuricae 1 part, Herba Polygoni cymosi 5 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Polygoni Cuspidati 3 parts, Flos Chrysanthemi Indici 0.5 part, Herba Houttuyniae 3 parts, Flos Lonicerae 0.8 part, Radix Sophorae Tonkinensis 0.5 part, Cortex Mori 0.7 part, Herba Solani Nigri 0.5 part, Semen Armeniacae Amarum 0.5 part, Herba Solidaginis 0.5 part, Rhizoma Osmundae 0.6 part.
A kind of Chinese medicine preparation treating oral disease, preparation technology is: be placed in extraction pot by above-mentioned each raw material, adds 100 parts of distilled water, 80 DEG C of heating extraction 40 minutes, filtering, filtrate is concentrated into the 1/2 of original volume then fine straining, add 0.1 part of Borneolum Syntheticum and 0.1 part of potassium sorbate, after fill, product.
Embodiment 2:
A kind of Chinese medicine preparation treating oral disease, is made up of the raw material of Chinese medicine of following masses number: Herba Verbenae 20 parts, 6 parts of Bulbus Allii, Radix Achyranthis Bidentatae 8 parts, the Radix Stemonae 30 parts, MAZHIXIAN 20 parts, Fructus Fici 15 parts, the Radix Angelicae Dahuricae 5 parts, Herba Polygoni cymosi 15 parts, Radix Sophorae Flavescentis 18 parts, Rhizoma Polygoni Cuspidati 6 parts, Flos Chrysanthemi Indici 5 parts, Herba Houttuyniae 10 parts, Flos Lonicerae 20 parts, Radix Sophorae Tonkinensis 0.6 part, Cortex Mori 4 parts, Herba Solani Nigri 9 parts, Semen Armeniacae Amarum 4 parts, Herba Solidaginis 15 parts, Rhizoma Osmundae 5 parts.
A kind of Chinese medicine preparation treating oral disease, preparation technology is: be placed in extraction pot by above-mentioned each raw material, adds 150 parts of distilled water, 85 DEG C of heating extraction 60 minutes, filtering, filtrate is concentrated into the 2/3 of original volume then fine straining, add 0.3 part of Borneolum Syntheticum and 0.3 part of potassium sorbate, after fill, product.
Embodiment 3:
A kind of Chinese medicine preparation treating oral disease, is made up of the raw material of Chinese medicine of following masses number: Herba Verbenae 30 parts, 10 parts of Bulbus Allii, Radix Achyranthis Bidentatae 15 parts, the Radix Stemonae 50 parts, MAZHIXIAN 30 parts, Fructus Fici 25 parts, the Radix Angelicae Dahuricae 10 parts, Herba Polygoni cymosi 25 parts, Radix Sophorae Flavescentis 30 parts, Rhizoma Polygoni Cuspidati 10 parts, Flos Chrysanthemi Indici 10 parts, Herba Houttuyniae 20 parts, Flos Lonicerae 40 parts, Radix Sophorae Tonkinensis 0.8 part, Cortex Mori 8 parts, Herba Solani Nigri 18 parts, Semen Armeniacae Amarum 8 parts, Herba Solidaginis 30 parts, Rhizoma Osmundae 10 parts.
A kind of Chinese medicine preparation treating oral disease, preparation technology is: be placed in extraction pot by above-mentioned each raw material, adds 200 parts of distilled water, 90 DEG C of heating extraction 80 minutes, filtering, filtrate is concentrated into the 2/3 of original volume then fine straining, add 0.5 part of Borneolum Syntheticum and 0.5 part of potassium sorbate, after fill, product.
Embodiment 4:
A kind of Chinese medicine preparation treating oral disease, is made up of the raw material of Chinese medicine of following masses number: Herba Verbenae 5 parts, 15 parts of Bulbus Allii, Radix Achyranthis Bidentatae 20 parts, the Radix Stemonae 5 parts, MAZHIXIAN 35 parts, Fructus Fici 5 parts, the Radix Angelicae Dahuricae 15 parts, Herba Polygoni cymosi 2 parts, Radix Sophorae Flavescentis 2 parts, Rhizoma Polygoni Cuspidati 15 parts, Flos Chrysanthemi Indici 15 parts, Herba Houttuyniae 25 parts, Flos Lonicerae 0.5 part, Radix Sophorae Tonkinensis 1 part, Cortex Mori 0.5 part, Herba Solani Nigri 20 parts, Semen Armeniacae Amarum 10 parts, Herba Solidaginis 0.2 part, Rhizoma Osmundae 15 parts.
A kind of Chinese medicine preparation treating oral disease, preparation technology is: be placed in extraction pot by above-mentioned each raw material, adds 80 parts of distilled water, 70 DEG C of heating extraction 90 minutes, filtering, filtrate is concentrated into the 1/2 of original volume then fine straining, add 0.8 part of Borneolum Syntheticum and 0.6 part of potassium sorbate, after fill, product.
Embodiment 5:
A kind of Chinese medicine preparation treating oral disease, is made up of the raw material of Chinese medicine of following masses number: Herba Verbenae 10 parts, 5 parts of Bulbus Allii, Radix Achyranthis Bidentatae 10 parts, MAZHIXIAN 10 parts, Fructus Fici 20 parts, the Radix Angelicae Dahuricae 8 parts, Herba Polygoni cymosi 20 parts, Radix Sophorae Flavescentis 10 parts, Rhizoma Polygoni Cuspidati 5 parts, Flos Chrysanthemi Indici 3 parts, Herba Houttuyniae 10 parts, Flos Lonicerae 15 parts, Cortex Mori 5 parts, Herba Solani Nigri 10 parts, Semen Armeniacae Amarum 5 parts, Rhizoma Osmundae 8 parts.
All the other are with embodiment 2.
Embodiment 6:
It is 201510847836.X by application number, denomination of invention is a kind of raw material treated disclosed in oral ulcer Chinese medicine formula and manufacture method and preparation method thereof, its medical material and weight: medical material, the jowar wines 500 grams such as 15 grams of mountain mast, Radix Scutellariae 15 grams, Fructus Forsythiae 30 grams, Herba Menthae 35 grams, Rhizoma Coptidis 30 grams, 45 grams of leaf of foot, Cortex Cinnamomi 15 grams, 35 grams of Radix Rehmanniae Preparata, Rhizoma Dioscoreae 25 grams, Rhizoma Alismatis 25 grams, Fructus Corni 25 grams, luxuriant Chinese catalpa grass 15 grams.The medicine of the treatment oral ulcer prepared.
Animal clinical study:
Animal: take 60 Kun Ming mice, body weight 18-22g, male and female half and half, be divided into 7 groups, often group 10, respectively matched group, embodiment 1-6 group.
Impact on rat skin wound healing: after rat is anesthetized with ether. dip in ink impression in the back cropping place card punch of diameter 9mm, then cut skin herein.Thereafter every day pressed 0.1ml/ dosage spray wound only, matched group not medication by the medicine that embodiment 1-6 group prepares embodiment 1-6 respectively, continuous 15 days, within the 5th day, the 10th day and the 15th day, measures wound area.
Result is in Table 1.
Table 1 present invention impact on rat wound healing
Result shows: the medicine that embodiment of the present invention 1-3 prepares can promote the healing of wound, effect is substantially better than embodiment 4 groups (technological parameter is different), embodiment 5 groups (few a few herbs raw material), embodiment 6 groups (the treatment stomatocace medicines of other patent disclosure), visible technological parameter, raw material of Chinese medicine selection all the curative effect of prepared medicine is had impact, therefore present invention employs specific raw material of Chinese medicine and technological parameter, prepare the medicine for the treatment of oral disease evident in efficacy.
Claims (6)
1. treat a Chinese medicine preparation for oral disease, it is characterized by: raw material is: Herba Verbenae, Bulbus Allii, Radix Achyranthis Bidentatae, the Radix Stemonae, MAZHIXIAN, Fructus Fici, the Radix Angelicae Dahuricae, Herba Polygoni cymosi, Radix Sophorae Flavescentis, Rhizoma Polygoni Cuspidati, Flos Chrysanthemi Indici, Herba Houttuyniae, Flos Lonicerae, Radix Sophorae Tonkinensis, Cortex Mori, Herba Solani Nigri, Semen Armeniacae Amarum, Herba Solidaginis, Rhizoma Osmundae.
2. treat a Chinese medicine preparation for oral disease, it is characterized by: be made up of the raw material of Chinese medicine of following masses number: Herba Verbenae 8-30 part, Bulbus Allii 2-10 part, Radix Achyranthis Bidentatae 0.5-15 part, Radix Stemonae 10-50 part, MAZHIXIAN 8-30 part, Fructus Fici 6-25 part, Radix Angelicae Dahuricae 1-10 part, Herba Polygoni cymosi 5-25 part, Radix Sophorae Flavescentis 6-30 part, Rhizoma Polygoni Cuspidati 3-10 part, Flos Chrysanthemi Indici 0.5-10 part, Herba Houttuyniae 3-20 part, Flos Lonicerae 0.8-40 part, Radix Sophorae Tonkinensis 0.5-0.8 part, Cortex Mori 0.7-8 part, Herba Solani Nigri 0.5-18 part, Semen Armeniacae Amarum 0.5-8 part, Herba Solidaginis 0.5-30 part, Rhizoma Osmundae 0.6-10 part.
3. a kind of Chinese medicine preparation treating oral disease as claimed in claim 2, it is characterized by: preparation technology is: above-mentioned each raw material is placed in extraction pot, add 100-200 part distilled water, 80-90 DEG C heating extraction 40-80 minute, filter, filtrate is concentrated into the 1/2-2/3 of original volume, fine straining again, add 0.1-0.5 part Borneolum Syntheticum and 0.1-0.5 part potassium sorbate, after fill, product.
4. a kind of Chinese medicine preparation treating oral disease as claimed in claim 2, is characterized by: using method is: direct-injection or pour oral cavity or throat, spray 3-4 time into.
5. a kind of Chinese medicine preparation treating oral disease as claimed in claim 4, is characterized by: when treatment oral ulcer or periodontitis, gingivitis, is contained in the mouth under 10-15 minute posterior phraynx or spue,.
6. a kind of Chinese medicine preparation treating oral disease as claimed in claim 4, is characterized by: during treatment pharyngolaryngitis, tonsillitis, cough, point several times to be swallowed, diet after half an hour.
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