CN105250628A - Orally-taken traditional Chinese medicine granular preparation for curing diabetic complication (diabetic foot) - Google Patents
Orally-taken traditional Chinese medicine granular preparation for curing diabetic complication (diabetic foot) Download PDFInfo
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- CN105250628A CN105250628A CN201510683356.4A CN201510683356A CN105250628A CN 105250628 A CN105250628 A CN 105250628A CN 201510683356 A CN201510683356 A CN 201510683356A CN 105250628 A CN105250628 A CN 105250628A
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Abstract
The invention discloses an orally-taken traditional Chinese medicine granular preparation for curing diabetic complication (diabetic foot). The granular preparation is characterized by comprising 667 g of rhizoma anemarrhenae, 333 g of honeysuckle stem, 333 g of honeysuckle, 333 g of rehmannia, 167 g of figwort, 167 g of liquorice, 167 g of fructus polygoni orientalis, as well as 667 g of processed angelica and 500 g of processed coptis chinensis. A production method of the granular preparation particularly comprises the following steps: crushing 222 g of processed angelica into fine angelica powder for standby application; adding water into such Chinese herbs as the remaining 445 g of processed angelica and 500 g of processed coptis chinensis for 1 hour's decoction twice, wherein the adding amount of water is 8 times of the total amount of the Chinese herbs; carrying out filtration, combining the obtained decoction solutions, and carrying out vacuum concentration to obtain clear paste I of which the relative density is 1.10-1.14 at 50 DEG C; adding ethanol to ensure a 70% ethanol content, and carrying out 24 hours' still standing and filtration; carrying out supernatant decompression to recover ethanol, and carrying out concentration to obtain clear paste II of which the relative density is 1.25-1.30 at 50-70 DEG C; carrying out vacuum drying at 70 DEG C or below to obtain dry paste; crushing the dry paste into fine powder; adding the 222 g of fine angelica powder for standby application; adding dextrin to increase the weight of the powder mixture to 1000 g; adding 3 g of magnesium stearate for uniform mixing; carrying out dry pressing to obtain granules, namely the granular preparation.
Description
Technical field:
What the present invention relates to is a kind of Chinese native medicine compound prescription pellet preparation, be specifically related to be one can cure diabetic complication (sugar foot) and can effective treatment diabetic complication cardio cerebrovascular affection, Eye disease, renal failure significantly improve the new medicine granular preparation for oral administration of diabetic complication patient immunity.
Background technology:
The diabetic complication fatality rate that disables is high, at present, the diabetics of the existing ill diagnosis and treatment record on the regular payroll in the whole world, more than 300,000,000 (actual diabetics has reached nearly 500,000,000), dies from complication number reality every year more than 5,200,000 people (WHO statistics in 2003).Latest survey shows, and China now exceedes India, becomes diabetes first big country.Diabetics in China adult, up to 9500-10,000 ten thousand, on average just has a people to be diabetes patient in every 14-15 people, or has had prediabetes sign.Prevention and control diabetes, especially prevention and control diabetic complication, very urgent.In the last few years, Chinese medicine was many to the report for the treatment of diabetes, but relatively less for the report for the treatment of diabetic complication.At present, domestic among the peoplely also have pure prescriptions of Chinese medicine to treat diabetic complication, but be only carry out treatment according to differentiation of diseases with soil single-prescription to patient, remains and be among initial understanding.What modern medicine adopted mostly to diabetic complication is oral antidiabetic drug and coordinates the Therapeutic Method of antibacterial liquid, and object is to control blood glucose, control the deterioration of complication, and more effective method is few.Once glycemic control lost efficacy, most employing amputation, and amputation is not only costly, and also Post operation most of patients can not heal for a long time or can not heal at all, thus bring larger misery to patient, to such an extent as to helplessly look at patient's lifelong disability or death.Current biological preparation is for the research and apply of diabetes and complication, cause the extensive concern of scholar in the industry, research worker and social relevant person, that studies along with pure Chinese medicine and biologics deepens continuously, what people caused modern Western medicine treatment diabetes and complication cures the symptoms, not the disease, and the understanding of the side effect brought thus is also more and more clearer.The hypoglycemic effect taken in metformin a period of time as simple is also obvious, but long-term taking not only blood glucose can not fall, complication also thereupon occur or disease aggravation.
Summary of the invention:
The object of this invention is to provide a kind of Chinese medicine for oral administration granular preparation of curing diabetic complication (sugar foot), it has effectively abandoned many drawbacks and the shortcoming of current treatment diabetic complication (sugar foot) medicine, and it effectively abandons these drawbacks and shortcoming by implementing following technical scheme:
Embodiment:
Detailed description of the invention one:
A kind of Chinese medicine for oral administration granular preparation of curing diabetic complication (sugar foot), is characterized in that it is made up of the Rhizoma Anemarrhenae 667 grams, Caulis Lonicerae 333 grams, Flos Lonicerae 333 grams, Radix Rehmanniae 333 grams, Radix Scrophulariae 167 grams, 167 grams, Radix Glycyrrhizae, Fructus Polygoni Orientalis 167 grams and the Radix Angelicae Sinensis 667 grams concocted through certain technique, Rhizoma Coptidis 500 grams.This granular preparation is characterized in that concrete manufacture method is: the Radix Angelicae Sinensis 222 grams of certain PROCESS FOR TREATMENT of learning from else's experience is ground into fine powder, for subsequent use; Group's medicine such as all the other 445 grams of Radix Angelicae Sinensis concocted through certain technique and 500 grams of Rhizoma Coptidis of concocting through certain technique adds 8 times amount soak by water 2 times, each 1h; Filter, collecting decoction, being evaporated to relative density is 1.10-1.14(50 DEG C) clear paste; Adding ethanol makes alcohol content reach 70%, places 24 hours, filters; Supernatant decompression recycling ethanol, being concentrated into relative density is 1.25-1.30(50 DEG C-70 DEG C) thick paste; Vacuum drying (less than 70 DEG C); Dried cream powder is broken into fine powder, adds 222 grams of Radix Angelicae Sinensis fine powders for subsequent use, adds dextrin to 1000g, add magnesium stearate 3g, and mixing, granule is made in dry-pressing, to obtain final product.
Detailed description of the invention two:
By practice of pharmacy, one of the present invention can be cured the Chinese medicine for oral administration granular preparation of diabetic complication (sugar foot), be prepared into various clinical pharmaceutical dosage form, comprise oral liquid, tablet, capsule, drop pill, suspensoid, any one in skin drug-delivery preparation, injection, suppository, aerosol etc.
Detailed description of the invention three:
Patent of the present invention is tested through pharmacological toxicology, and the display of its result of study has following functions:
1, stronger promotion experimental diabetic rats Ulcer Models union of wounded skin effect is had;
2, diabetic mice, rat model blood glucose can obviously be reduced;
3, the stronger In-vitro Inhibitory Effect to common pathogen is had;
4, to the protective effect of infection of staphylococcus aureus mice;
5, to the protective effect of charrin's disease mice;
6, auricular microcirculation obstacle can obviously be improved;
7, anti-inflammation effect is stronger;
8, obvious analgesic activity is had;
9, there is stronger analgesic activity;
10, the humoral immune function of immunologic hypofunction mice is improved;
11, stronger promotion experimental diabetic rats Ulcer Models union of wounded skin effect is had.
Claims (4)
1. cure a Chinese medicine for oral administration granular preparation for diabetic complication (sugar foot), it is characterized in that it is made up of the Rhizoma Anemarrhenae 667 grams, Caulis Lonicerae 333 grams, Flos Lonicerae 333 grams, Radix Rehmanniae 333 grams, Radix Scrophulariae 167 grams, 167 grams, Radix Glycyrrhizae, Fructus Polygoni Orientalis 167 grams and the Radix Angelicae Sinensis 667 grams concocted through certain technique, Rhizoma Coptidis 500 grams.
2. cure the Chinese medicine for oral administration granular preparation of diabetic complication (sugar foot) for one kind, it is characterized in that this granular preparation can not only cure diabetic complication (sugar foot), and to diabetic complication Eye disease, cardio cerebrovascular affection, renal failure, also there is remarkable therapeutic effect, and there is no toxic and side effects.
3. cure a Chinese medicine for oral administration granular preparation for diabetic complication (sugar foot), it is characterized in that concrete manufacture method is: the Radix Angelicae Sinensis 222 grams that certain technique of learning from else's experience is concocted is ground into fine powder, for subsequent use; Group's medicine such as all the other 445 grams of Radix Angelicae Sinensis concocted through certain technique and 500 grams of Rhizoma Coptidis of concocting through certain technique adds 8 times amount soak by water 2 times, each 1h; Filter, collecting decoction, being evaporated to relative density is 1.10-1.14(50 DEG C) clear paste; Adding ethanol makes alcohol content reach 70%, places 24 hours, filters; Supernatant decompression recycling ethanol, being concentrated into relative density is 1.25-1.30(50 DEG C-70 DEG C) thick paste; Vacuum drying (less than 70 DEG C); Dried cream powder is broken into fine powder, adds 222 grams of Radix Angelicae Sinensis fine powders for subsequent use, adds dextrin to 1000g, add magnesium stearate 3g, and mixing, granule is made in dry-pressing, to obtain final product.
4. press practice of pharmacy, Chinese medicine for oral administration granular preparation one of the present invention can being cured diabetic complication (sugar foot) is prepared into various clinical pharmaceutical dosage form, comprise the dosage form of oral formulations or parenterai administration, mainly refer to tablet, capsule, drop pill, suspensoid, oral liquid, any one in percutaneous drug delivery agent, injection, suppository, aerosol etc.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510683356.4A CN105250628A (en) | 2015-10-22 | 2015-10-22 | Orally-taken traditional Chinese medicine granular preparation for curing diabetic complication (diabetic foot) |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510683356.4A CN105250628A (en) | 2015-10-22 | 2015-10-22 | Orally-taken traditional Chinese medicine granular preparation for curing diabetic complication (diabetic foot) |
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| CN105250628A true CN105250628A (en) | 2016-01-20 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528662A (en) * | 2019-01-11 | 2019-03-29 | 山东万安药业股份有限公司 | A kind of traditional Chinese medicine for oral administration granular preparation that treating diabetic foot ulcer and preparation method |
| CN117482168A (en) * | 2023-11-29 | 2024-02-02 | 唐宁医药科技(济南)有限公司 | Preparation method of Guizhi sugar-coated preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656111A (en) * | 2012-09-06 | 2014-03-26 | 唐贝宁医药科技（北京）有限公司 | Internal traditional Chinese medicine preparation for preventing and treating diabetic foot and preparation method thereof |
-
2015
- 2015-10-22 CN CN201510683356.4A patent/CN105250628A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656111A (en) * | 2012-09-06 | 2014-03-26 | 唐贝宁医药科技（北京）有限公司 | Internal traditional Chinese medicine preparation for preventing and treating diabetic foot and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528662A (en) * | 2019-01-11 | 2019-03-29 | 山东万安药业股份有限公司 | A kind of traditional Chinese medicine for oral administration granular preparation that treating diabetic foot ulcer and preparation method |
| CN117482168A (en) * | 2023-11-29 | 2024-02-02 | 唐宁医药科技(济南)有限公司 | Preparation method of Guizhi sugar-coated preparation |
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Application publication date: 20160120 |