CN104000898A - Pharmaceutical composition capable of preventing and treating hyperlipidemia, and preparation method thereof - Google Patents
Pharmaceutical composition capable of preventing and treating hyperlipidemia, and preparation method thereof Download PDFInfo
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- CN104000898A CN104000898A CN201310182616.0A CN201310182616A CN104000898A CN 104000898 A CN104000898 A CN 104000898A CN 201310182616 A CN201310182616 A CN 201310182616A CN 104000898 A CN104000898 A CN 104000898A
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- extract
- pharmaceutical composition
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- salviae miltiorrhizae
- radix salviae
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Abstract
The invention discloses a pharmaceutical composition capable of preventing and treating hyperlipidemia, and a preparation method thereof. The pharmaceutical composition is used for preventing and treating hyperlipidemia. The pharmaceutical composition is prepared from the following raw materials by weight: 20-1 parts of salvia extract and 1-20 parts of hawthorn extract. The pharmaceutical composition also comprises auxiliary materials frequently-used in pharmacy. A preparation process of the pharmaceutical composition comprises the steps of making the hawthorn and salvia into water extract or alcohol extract individually; concentrating filtrate; purifying by using a macroporous resin; feeding the salvia extract and hawthorn extract directly; and making a plurality of preparations according to a common method. The pharmaceutical composition has a synergistic effect, has an obviously enhanced effect relative to salvia extract or hawthorn extract individually, is safe and has no toxicity.
Description
Technical field
The present invention relates to composition of medicine technical field, is exactly pharmaceutical composition of a kind of prevention and treatment hyperlipidemia and preparation method thereof.
Background technology
Hyperlipidemia is a kind of disease of serious harm human health, and current Therapeutic Method has a variety of, has operative therapy, and western medicines in treatment medicine is also a lot, and Western medicine generally has certain side effect, and Chinese medicine side effect is less, and has certain preventive effect.The unit that carries out at present the research of Traditional Chinese medicine for treating hyperlipidemia disease is also a lot, has some also to apply for Chinese invention patent; As Chinese patent CN101084992A discloses the patent of invention that a kind of name is called " a kind of pharmaceutical composition that contains Flos Carthami and Radix Ginseng, preparation method and preparation ", it is made as crude drug taking Radix Salviae Miltiorrhizae, Flos Carthami, Radix Ginseng and Moschus or muscone, and its step of preparation process is: (1) is by Radix Salviae Miltiorrhizae, Flos Carthami and Radix Ginseng mixing or make separately water extraction liquid or alcohol extract; (2) described extracting solution is carried out to preliminary clarifying treatment; (3) further described extracting solution is carried out to hyperfiltration treatment; (4) ultrafiltrate is concentrated, add Moschus or muscone, make according to a conventional method preparation.Above-mentioned raw materials medicine Radix Ginseng can replace with Radix Codonopsis.
Also have a kind of application of the compositions for the preparation for the treatment of cardiovascular and cerebrovascular diseases medicament of being made up by a certain percentage of Radix Salviae Miltiorrhizae and Fructus Trichosanthis, this pharmaceutical composition can be made any clinical or pharmaceutically acceptable preparation, optimizing injection and oral formulations.Radix Salviae Miltiorrhizae in this pharmaceutical composition can also replace with Radix Salviae Miltiorrhizae extract, and Fructus Trichosanthis can also replace with Fructus Trichosanthis extract, directly feeds intake with Radix Salviae Miltiorrhizae extract and Fructus Trichosanthis extract.This pharmaceutical composition has synergistic function, and good stability is better than the effect of alone Radix Salviae Miltiorrhizae extract or Fructus Trichosanthis extract.
Chinese patent CN200410086489.5 discloses " a kind of Chinese medicine composition for the treatment of hyperlipidemia and preparation method thereof ", application for a patent for invention, in invention, Chinese medicine composition is formulated by Fructus Crataegi extract, Hongqu powder (red colouring agent), for prevention and treatment hyperlipidemia, can be used for the cardiovascular and cerebrovascular disease that prevention is relevant to hyperlipidemia with treatment, its determined curative effect simultaneously; Preparation method of the present invention compared with prior art has the features such as technique is simple, the quality of production is easily controlled, production cost is low.
CN201210302281.7 discloses the patent of invention of " a kind of Radix Salviae Miltiorrhizae hawthorn beverage and preparation method thereof ", and this Radix Salviae Miltiorrhizae hawthorn beverage is that raw material is made by the pure water of the food flavoring agent of the Fructus Crataegi powder of the Radix Salviae Miltiorrhizae powder of 1 ~ 5 weight portion, 1 ~ 10 weight portion, 5 ~ 8 weight portions, 125 ~ 185 weight portions or mineral water or cold water.This preparation method is carried out as follows: a, by Radix Salviae Miltiorrhizae powder and Fructus Crataegi powder are placed in and are decocted in container, add the water soaking 0.1 ~ 2h of 55 ~ 80 weight portions, and heat and decoct 15-25min after boiling, to filter, filtering residue and filtrate are for subsequent use; B. the filtering residue of getting a step adds remaining water and food flavoring agent, heats and decoct 10 ~ 20min after boiling, and filters, and filtrate is for subsequent use; C, the filtrate of a step and b step is merged, sterilizing, fill, obtain product.
Summary of the invention
The object of this invention is to provide pharmaceutical composition of a kind of prevention and treatment hyperlipidemia and preparation method thereof.
The present invention carries out ratio optimization for the clinical effective prescription in existing source, through repetition test and clinical choose preparation and compositions, form pharmaceutical composition prescription with Fructus Crataegi extract and Radix Salviae Miltiorrhizae extract, be applied to prevention and treatment hyperlipidemia, can be used for the cardiovascular and cerebrovascular disease that prevention is relevant to hyperlipidemia with treatment simultaneously.
The present invention can be used for the cardiovascular and cerebrovascular disease that prevention is relevant to hyperlipidemia with treatment simultaneously.It is characterized in that: it is mainly prepared from by the raw material of following weight portion proportioning: Radix Salviae Miltiorrhizae extract 20-1 part, Fructus Crataegi extract 1-20 part.Wherein preferred 10-20 part of Radix Salviae Miltiorrhizae extract.The preferred 1-10 part of Fructus Crataegi extract.Described pharmaceutical composition and pharmaceutically acceptable auxiliary material combination are prepared into acceptable dosage form clinically.Preparation technology is: by proportioning, Fructus Crataegi, Radix Salviae Miltiorrhizae are made separately to water extraction liquid or alcohol extract, filtrate is concentrated, further with purification with macroreticular resin, described macroporous resin is selected from D101, AB-8, after purification, obtain respectively Radix Salviae Miltiorrhizae extract and Fructus Crataegi extract, directly feed intake with Radix Salviae Miltiorrhizae extract and Fructus Crataegi extract, make according to a conventional method preparation.Dosage form can be pill, capsule, granule, tablet and injection etc.
Advantage of the present invention is: Synergistic, safety non-toxic.Its preparation method compared with prior art have technique advanced person, quality control comprehensively, the feature such as determined curative effect.
Detailed description of the invention
the preparation of Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract:
Get red rooted salvia, add water 12 times and measure reflux, extract, three times, each 2h, extracting solution filters, and merges, be concentrated into 0.2g/ml, by AB-8 type macroporous adsorptive resins, water and 50% ethanol elution successively, collects 50% ethanol elution, reclaim ethanol, concentrated, dry, obtain Radix Salviae Miltiorrhizae extract.
Get Fructus Crataegi medical material, with 10 times of amount 75% alcohol reflux twice, each 1h, filter, merging filtrate, and concentrated medicament concentration is to 1.0g/ml, by AB-8 type macroporous adsorptive resins, water and 70% ethanol elution, discard water lotion successively, collects 70% ethanol elution, reclaim ethanol, concentrated, dry, obtain Fructus Crataegi extract.
Embodiment 1
Get 20 parts of Radix Salviae Miltiorrhizae extracts (weight ratio), 1 part of Fructus Crataegi extract (weight ratio), makes pill according to a conventional method.Wherein contain the conventional batching of the pills such as Mel.
Embodiment 2
Get 15 parts of Radix Salviae Miltiorrhizae extracts (weight ratio), 5 parts of Fructus Crataegi extracts (weight ratio), make capsule according to a conventional method.
Embodiment 3
Get 10 parts of Radix Salviae Miltiorrhizae extracts (weight ratio), 10 parts of Fructus Crataegi extracts (weight ratio), granulation agent according to a conventional method.
Embodiment 4
Get 1 part of Radix Salviae Miltiorrhizae extract (weight ratio), 20 parts of Fructus Crataegi extracts (weight ratio), make tablet according to a conventional method.
Embodiment 5
Get 10 parts of Radix Salviae Miltiorrhizae extracts (weight ratio), 10 parts of Fructus Crataegi extracts (weight ratio), make aqueous injection or lyophilized injectable powder according to a conventional method.
Toxicological test:
With female white mice each 10, be divided into 5 groups, heavy dose of administration, observes, unchanged.
The test of pesticide effectiveness:
Select 100 to suffer from each 50 of hyperlipidemia men and women patient through making a definite diagnosis, patient age difference, respectively by three different dosage form administrations every day, administration is after 30 days, and through clinical examination, the most of patients state of an illness has improvement in various degree, and total effective rate is 76.6%.
Claims (6)
1. a pharmaceutical composition for prevention and treatment hyperlipidemia, is characterized in that: it is mainly prepared from by the raw material of following weight portion proportioning, wherein Radix Salviae Miltiorrhizae extract 20-1 part, Fructus Crataegi extract 1-20 part.
2. the pharmaceutical composition of a kind of prevention according to claim 1 and treatment hyperlipidemia, is characterized in that: wherein Radix Salviae Miltiorrhizae extract 10-20 part.
3. the pharmaceutical composition of a kind of prevention according to claim 1 and treatment hyperlipidemia, is characterized in that: Fructus Crataegi extract 1-10 part.
4. the pharmaceutical composition of a kind of prevention described in any one and treatment hyperlipidemia according to claim 1-3: it is characterized in that, described compositions with learn upper acceptable adjuvant and be prepared into the preparation of accepting clinically.
5. a kind of preparation method of preventing and treating the pharmaceutical composition of hyperlipidemia as claimed in claim 1: Fructus Crataegi, Radix Salviae Miltiorrhizae are made separately to water extraction liquid or alcohol extract, filtrate is concentrated, further with purification with macroreticular resin, directly feed intake with Radix Salviae Miltiorrhizae extract and Fructus Crataegi extract, make according to a conventional method preparation.
6. the preparation method of the pharmaceutical composition of a kind of prevention according to claim 5 and treatment hyperlipidemia, described preparation is pill, capsule, granule, tablet or injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310182616.0A CN104000898A (en) | 2013-02-26 | 2013-05-17 | Pharmaceutical composition capable of preventing and treating hyperlipidemia, and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310059890.9 | 2013-02-26 | ||
| CN201310059890 | 2013-02-26 | ||
| CN201310182616.0A CN104000898A (en) | 2013-02-26 | 2013-05-17 | Pharmaceutical composition capable of preventing and treating hyperlipidemia, and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104000898A true CN104000898A (en) | 2014-08-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310182616.0A Pending CN104000898A (en) | 2013-02-26 | 2013-05-17 | Pharmaceutical composition capable of preventing and treating hyperlipidemia, and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109633A (en) * | 2016-07-18 | 2016-11-16 | 山东福瑞达医药集团公司 | A kind of Chinese medicine composition with blood fat reducing function and preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1827130A (en) * | 2004-05-19 | 2006-09-06 | 烟台同和医药科技有限公司 | Formulation prepared from effective parts of red sage root and moutan bark, its compound preparation method and medical application |
| CN101455739A (en) * | 2007-12-14 | 2009-06-17 | 北京琥珀光华医药科技开发有限公司 | Pure traditional Chinese medicine preparation for treating hyperlipemia |
-
2013
- 2013-05-17 CN CN201310182616.0A patent/CN104000898A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1827130A (en) * | 2004-05-19 | 2006-09-06 | 烟台同和医药科技有限公司 | Formulation prepared from effective parts of red sage root and moutan bark, its compound preparation method and medical application |
| CN101455739A (en) * | 2007-12-14 | 2009-06-17 | 北京琥珀光华医药科技开发有限公司 | Pure traditional Chinese medicine preparation for treating hyperlipemia |
Non-Patent Citations (2)
| Title |
|---|
| 张国梅: "大孔吸附树脂纯化山楂总黄酮的研究", 《中药材》 * |
| 谢梅林等: "消瘀片对实验性高血脂症兔的治疗作用研究", 《中国现代应用药学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109633A (en) * | 2016-07-18 | 2016-11-16 | 山东福瑞达医药集团公司 | A kind of Chinese medicine composition with blood fat reducing function and preparation method and application |
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Application publication date: 20140827 |
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| RJ01 | Rejection of invention patent application after publication |