CN102198223A - Medicinal preparation for treating hepatitis and cholecystitis and preparation method thereof - Google Patents
Medicinal preparation for treating hepatitis and cholecystitis and preparation method thereof Download PDFInfo
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- CN102198223A CN102198223A CN201010130971XA CN201010130971A CN102198223A CN 102198223 A CN102198223 A CN 102198223A CN 201010130971X A CN201010130971X A CN 201010130971XA CN 201010130971 A CN201010130971 A CN 201010130971A CN 102198223 A CN102198223 A CN 102198223A
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Abstract
The invention relates to a medicinal preparation for treating hepatitis and cholecystitis, which is characterized by being prepared from swertia pseudochinensis hara, longhairy antenoron herb, lagotis, rhubarb and the like. The medicinal preparation can be prepared into oral preparations such as tablets, granules, oral liquid, syrup and the like and has the effects of clearing liver and gall and eliminating dampness and heat, the total effective rate of treating the hepatitis clinically is 96.6 percent, and the total effective rate of treating acute and chronic cholecystitis is 91 percent. Adverse effects do not occur in the clinical observation process, so the medicinal preparation is an ideal medicament for treating the hepatitis and the cholecystitis.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation, especially treat pharmaceutical preparation of liver and gall diseases and preparation method thereof, diseases such as hepatitis, cholecystitis are all had the obvious treatment effect.Its dosage form comprises common peroral dosage forms such as tablet, granule, oral liquid.
Background technology
The various hepatitis of China is presenting ascendant trend, has every year nearly 400,000 people to die from hepatic disease, and chronic viral hepatitis B and lost hepatitis C are just becoming the killer of compatriots' health.Cholecystitis divides acute and chronic two kinds, sees clinically more, and is higher with women's sickness rate fat, voluminous, about 40 years old especially.Cholecystitis is generally the syndrome of cholelithiasis, and the sickness rate of cholelithiasis accounts for more than 70%.From theory of medicine, cholecystitis can be divided into acute and chronic, but in fact great majority are chronic, begin that disease symptom is very light several times, and pain is severity not too, often is mistaken as gastropathy and is not caused attention.
Liver and gall diseases seriously jeopardizes people's health.People press for and develop good effect, and the medicine that toxic and side effects is low is treated liver and gall diseases.Chinese medicine, Tibetan medicine, mongolian medicine have embodied greatly advantage in this respect at present.Compare with Western medicine, the ethnic drug treatment has advantages such as comprehensively regulating, side effect is little, relapse rate is low.Therefore the exploitation of this medicine has great social significance.
Summary of the invention
The purpose of this invention is to provide a kind of liver heat removing function of gallbladder promoting, the pharmaceutical preparation that has obvious curative effects for the hepatitis cholecystitis.Pharmacodynamic experiment shows that this product can have significant protective effect to the experimental damage of the rat that thioacetamide causes; can promote the biliary secretion of rat; show that this medical instrument protects the liver, reduce the effect of glutamate pyruvate transaminase in the serum, viral hepatitis is had curative effect preferably.Acute toxicity test and long term toxicity test result show that all this preparation safety is nontoxic.
The invention belongs to a kind of pharmaceutical preparation of liver heat removing function of gallbladder promoting, it is characterized in that forming by the medicament composing prescription of liver heat removing function of gallbladder promoting, comprise that 6～15 parts of Herba Swertiae bimaculataes, 6～15 parts of Herba Lysimachiaes, 6～15 parts of Radix Pecteilis susannae, 3～6 parts of technical schemes of the present invention of Radix Et Rhizoma Rhei are: the medical material of respectively distinguishing the flavor of among the present invention is extracted, be condensed into thick paste, after being dried to dry powder, can be made into oral formulations such as tablet, granule by adding different auxiliary material.The different auxiliary material that adds in the different dosage form among the present invention does not influence clinical effectiveness of the present invention, and these adjuvants comprise starch, dextrin, sucrose etc.The present invention can satisfy hepatitis and the cholecystitis patient demand to different dosage form.
Characteristics of the present invention and effect are: utilization we treatment hepatitis B patient 150 examples, be divided into treatment group 100 example and matched group 50 examples at random, and the treatment to we is organized in treatment, and matched group is given the treatment of Chinese patent medicine Lamy stationary slice.As a result, treatment group total effective rate is 93%, and the matched group total effective rate is 78%.Two groups relatively, and significant difference (P＜0.01) shows that we's treatment hepatitis B curative effect is comparatively desirable.Use we's treatment cholecystitis 60 examples: case is divided into 2 groups at random, observation group's 60 examples, matched group 40 all meets the diagnostic criteria of cholecystitis.Observation group adopts we, and matched group gives the Anetholtnithoines treatment.15 days one courses of treatment.Through 4 courses of treatment, observation group: cure 30 examples (50%) in the recent period, produce effects 18 examples (30%), 7 examples that take a turn for the better (11.7%), invalid 5 examples (8.37%), total effective rate 91.7%.Matched group: cure 9 examples (22.5%) in the recent period, produce effects 13 examples (32.5%), 10 examples that take a turn for the better (25%), invalid 8 examples (20%), total effective rate 80%.Observation group's total effective rate is better than matched group.In the clinical observation process, do not see untoward reaction.It is the comparatively ideal medicine of a kind of liver heat removing function of gallbladder promoting.
Prescription of the present invention also can comprise 3～9 parts of Radix Gentianae, 6～15 parts on Flos Carthami, 6～15 parts of Fructus Gardeniaes, 6～15 parts of the Radixs Astragali, 3～9 parts in Radix Glycyrrhizae, 3～9 parts of flavour of a drug of Fructus Schisandrae Chinensis, above-mentioned flavour of a drug can wholely add wherein any two to three flavor medicines as required, and make preparation by extraction process of the present invention.
The specific embodiment
The invention will be further described below by implementing, and its purpose only is to understand better content of the present invention and unrestricted protection scope of the present invention:
Embodiment 1
Take by weighing Radix Gentianae 600g, Radix Pecteilis susannae 1500g, Herba Swertiae bimaculatae 1200g, Herba Lysimachiae 900g, Radix Et Rhizoma Rhei 600g, Fructus Schisandrae Chinensis 600g adds 50% alcohol reflux 3 times, each 2 hours, each alcohol adding amount is 6 times of medical material, and merge extractive liquid, filters, and reclaims ethanol, concentrate and make extractum (proportion 1.25～1.35), it is an amount of to add dextrin, drying under reduced pressure (70-90 ℃), pulverize, granulate drying, granulate is made 4000g, promptly gets granule of the present invention.(one time 1 bag, one day 2 times)
Embodiment 2
Take by weighing Radix Pecteilis susannae 600g, Herba Swertiae bimaculatae 900g, Herba Lysimachiae 1500g, Radix Et Rhizoma Rhei 300g, Fructus Gardeniae 600g, Radix Glycyrrhizae 900g adds 70% alcohol reflux 4 times, each 2 hours, each alcohol adding amount was 8 times of medical material, merge extractive liquid,, filter, reclaim ethanol, concentrating under reduced pressure makes extractum (proportion 1.10～1.12, add starch, one-step palletizing, tabletting, coating is made 3200, promptly gets tablet of the present invention.(one time 2, one day 2 times)
Embodiment 3
Take by weighing Herba Swertiae bimaculatae 900g, Herba Lysimachiae 1200g, Radix Pecteilis susannae 900g, Radix Et Rhizoma Rhei 600g, Flos Carthami 900g, Radix Glycyrrhizae 900g, Fructus Schisandrae Chinensis 900g, add 60% alcohol reflux 2 times, each 2 hours, each alcohol adding amount was 10 times of medical material, merge extractive liquid,, filter, filtrate is carried out ultrafiltration with the ultrafilter membrane of molecular cut off 10000, reclaims ethanol, concentrating under reduced pressure makes concentrated solution (proportion 1.08～1.10), add an amount of sucrose, thin up is to 25000ml, and is centrifugal with 15000 rev/mins of rotating speeds, get supernatant, add an amount of correctives, antiseptic and fill, oral liquid of the present invention is promptly made in sterilization.(one time 1, one day 2 times)
Embodiment 4
Take by weighing Herba Swertiae bimaculatae 1500g, Herba Lysimachiae 1200g, Radix Pecteilis susannae 900g, Radix Et Rhizoma Rhei 600g, Radix Gentianae 900g, Fructus Gardeniae 900g, Radix Astragali 900g adds 50% alcohol reflux 4, each 1.5 hours, each alcohol adding amount is 6 times of medical material, and merge extractive liquid, filters, reclaim ethanol, filtrate decompression concentrates and makes extractum (proportion 1.08～1.10), and is spray-dried, add appropriate amount of auxiliary materials, make 2000 balls, promptly get pill of the present invention.(one time 1 ball, one day 2 times)
The ethnic drug of liver heat removing function of gallbladder promoting is few clinically at present, liver heat removing gallbladder of the present invention, dampness removing heat.Be used for hepatitis, the treatment of cholecystitis, technology is simple, and good effect has certain value of exploiting and utilizing.
Claims (3)
1. pharmaceutical preparation for the treatment of hepatitis, cholecystitis is characterized in that he is by comprising that the following dosage proportion raw material makes: 6～15 parts of Herba Swertiae bimaculataes, 6～15 parts of Herba Lysimachiaes, 6～15 parts of Radix Pecteilis susannae, 3～6 parts of Radix Et Rhizoma Rhei.
2. a kind of pharmaceutical preparation for the treatment of hepatitis, cholecystitis according to claim 1, it is characterized in that also can comprising in the described raw material 3～9 parts of Radix Gentianae, 6～15 parts on Flos Carthami, 6～15 parts of Fructus Gardeniaes, 6～15 parts of the Radixs Astragali, 3～9 parts in Radix Glycyrrhizae, 3～9 parts of flavour of a drug of Fructus Schisandrae Chinensis, above-mentioned flavour of a drug can add wherein any two to three flavor medicines as required.
3. according to the preparation method of the pharmaceutical preparation of claim 1,2 described treatment hepatitis, cholecystitis, it is characterized in that preparation technology carries out as follows: get above medical material and add 50-70% alcohol reflux 2-4 time, merge extractive liquid,, reclaim ethanol, concentrate, make oral formulations commonly used with proper auxiliary materials such as sucrose, dextrin, starch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010130971XA CN102198223A (en) | 2010-03-24 | 2010-03-24 | Medicinal preparation for treating hepatitis and cholecystitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010130971XA CN102198223A (en) | 2010-03-24 | 2010-03-24 | Medicinal preparation for treating hepatitis and cholecystitis and preparation method thereof |
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| CN102198223A true CN102198223A (en) | 2011-09-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201010130971XA Pending CN102198223A (en) | 2010-03-24 | 2010-03-24 | Medicinal preparation for treating hepatitis and cholecystitis and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285119A (en) * | 2012-03-02 | 2013-09-11 | 中国人民解放军第三〇二医院 | Chinese medicine composition for treating autoimmune liver disease, and preparation method thereof |
| CN103690786A (en) * | 2013-11-25 | 2014-04-02 | 顾燕君 | Traditional Chinese medicine for treating post-hepatitis syndrome |
| CN104721389A (en) * | 2015-04-02 | 2015-06-24 | 郝海兵 | Traditional Chinese medicine composition for treating cholesterolosis of gallbladder |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1383881A (en) * | 2002-05-23 | 2002-12-11 | 刘民安 | Gansukang capsule |
| CN1660323A (en) * | 2004-12-19 | 2005-08-31 | 青海君吒药业有限公司 | 'Qiwei gandanqing' capsule for treating disease of liver and gall |
| CN1857615A (en) * | 2006-03-23 | 2006-11-08 | 张玲 | Medicine for treating hepatitis and cholecystitis and its preparing method and application |
-
2010
- 2010-03-24 CN CN201010130971XA patent/CN102198223A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1383881A (en) * | 2002-05-23 | 2002-12-11 | 刘民安 | Gansukang capsule |
| CN1660323A (en) * | 2004-12-19 | 2005-08-31 | 青海君吒药业有限公司 | 'Qiwei gandanqing' capsule for treating disease of liver and gall |
| CN1857615A (en) * | 2006-03-23 | 2006-11-08 | 张玲 | Medicine for treating hepatitis and cholecystitis and its preparing method and application |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285119A (en) * | 2012-03-02 | 2013-09-11 | 中国人民解放军第三〇二医院 | Chinese medicine composition for treating autoimmune liver disease, and preparation method thereof |
| CN103285119B (en) * | 2012-03-02 | 2014-11-19 | 中国人民解放军第三〇二医院 | Chinese medicine composition for treating autoimmune liver disease, and preparation method thereof |
| CN103690786A (en) * | 2013-11-25 | 2014-04-02 | 顾燕君 | Traditional Chinese medicine for treating post-hepatitis syndrome |
| CN104721389A (en) * | 2015-04-02 | 2015-06-24 | 郝海兵 | Traditional Chinese medicine composition for treating cholesterolosis of gallbladder |
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Application publication date: 20110928 |