CN101693068B - Medicament for lowering blood pressure and blood lipid - Google Patents
Medicament for lowering blood pressure and blood lipid Download PDFInfo
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- CN101693068B CN101693068B CN2009101144837A CN200910114483A CN101693068B CN 101693068 B CN101693068 B CN 101693068B CN 2009101144837 A CN2009101144837 A CN 2009101144837A CN 200910114483 A CN200910114483 A CN 200910114483A CN 101693068 B CN101693068 B CN 101693068B
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Abstract
The invention relates to a medicament for lowering blood pressure and blood lipid, which is prepared from the following raw material medicines in proportion by weight: 100-2000 parts of Hainan holly leaf, 100-2000 parts of sanchi leaf, 100-2000 parts of cassia seed, 100-2000 parts of radix paeoniae alba and 10-200 parts of dried orange peel. The medicament has the functions of clearing heat, relieving lung, eliminating phlegm and promoting blood circulation, is mainly used for treating symptoms including hypertension, hyperlipemia, megrim caused by liver-yang hyperactivity and the like, has simple production process and easy operation of raw materials, and can be prepared into various pharmaceutical preparation formulations.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of hypertension, hyperlipemia, particularly a kind of heat clearing away suppressing the hyperactive liver reduces phlegm and invigorates blood circulation, the traditional Chinese compound medicine of the disease such as dizzy that cures mainly that hypertension, hyperlipemia and excessive rising of liver-YANG cause.
Background technology
Cardiovascular system diseases is a human the most common class disease, has become the first cause of the death of world today's population.In recent years, along with China steps into aging society gradually, living standards of the people improve, rhythm of life is accelerated, dietary habit is to hyperpyrexia, high fat development, and cardiovascular system diseases such as hypertension, hyperlipidemia, heart failure, apoplexy have become one of serious disease of harm humans health and life among the crowd.Cardiovascular disease have disease plant many, sickness rate is high, and characteristics such as human survival is in close relations, the research that causes people to capture cardiovascular disease deepens continuously, and hypertension, hyperlipemia are common clinical, frequently-occurring disease, the infringement of target organs such as the heart that it caused, brain, kidney in addition, cause the generation of multiple complications such as cerebral hemorrhage, myocardial infarction, renal dysfunction, have a strong impact on patient's quality of life.In recent years, along with the growth of the improving constantly of China's living standards of the people, aging population, hypertension, hyperlipemia are just becoming the high commonly encountered diseases of a kind of prevalence and are coming into our life.At present the whole world does not still have effective means and can effect a radical cure hypertension, hyperlipemia, and this is sick in case suffer from and will follow lifelong and cause a lot of other relevant diseases.
Domestic hospital antihypertensive drug commonly used is mainly based on calcium channel blocker (Horizon class), ACE-I (Puli's class) and hypertensinase-II inhibitor (husky smooth class) three major types medicine, Western medicine class hypolipidemic is that Statins is taken product as the leading factor, and Chinese medicine class cardiovascular disease therapies medicine preparation becomes the best selling variety on the domestic market gradually.Compare with Western medicine preparation, Chinese medicine preparation has " many target spots, manifold effect " effect, because theory of Chinese medical science is thought, human body is an integral body, so blood-activating stasis-removing kind Chinese medicine has multiple effects such as atheromatous plaque, dredging vascellum and the accelerate blood circulation of elimination, so Chinese medicine class cardiovascular diseases preparation is compared the advantage of having more with the single Western medicine preparation of effect.As long as Chinese medicine preparation is: FUFANG DANSHEN DIWAN, FUFANG DANSHEN PIAN, puerarin injection, BUCHANG NAOXINTONG, MAILUONING ZHUSHEYE, this shows the approval of the numerous patients of China to Chinese medicine class cardiovascular preparation clinical efficacy.But above Drug therapy is cured the symptoms, not the disease a bit, and some uses expensive composition, and a lot of products do not possess the effect of blood pressure lowering, blood fat reducing simultaneously.
Summary of the invention
The purpose of this invention is to provide the pharmaceutical preparation, particularly heat clearing away suppressing the hyperactive liver of a kind of prevention and treatment hypertension, hyperlipemia, reduce phlegm and invigorate blood circulation, the traditional Chinese compound medicine of the disease such as dizzy that cures mainly that hypertension, hyperlipemia and excessive rising of liver-YANG cause.
The present invention is achieved like this:
It is made by following materials of weight proportions medicine: 100～2000 parts of Folium Ilicis hainanensis, 100～2000 parts of Folium Notoginsengs, 100～2000 parts of Semen Cassiaes, 100～2000 parts of the Radix Paeoniae Albas, 10～200 parts of Pericarpium Citri Reticulataes.Preferred weight proportion is: 1600 parts of Folium Ilicis hainanensis, 1600 parts of Folium Notoginsengs, 1600 parts of Semen Cassiaes, 1600 parts of the Radix Paeoniae Albas, 160 parts of Pericarpium Citri Reticulataes.
Preparation method is: getting Folium Ilicis hainanensis, to be ground into coarse powder standby; Folium Notoginseng, Semen Cassiae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae decoct with water three times, add 10 times of amounts of water for the first time, decoct 1 hour, for the second time add 8 times of amounts of water, decocted 1 hour, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, it is 1.20～1.30/60 ℃ clear paste that filtrate is concentrated into relative density, add above-mentioned Folium Ilicis hainanensis coarse powder, mixing is made granule, drying, promptly.
The present invention has the heat clearing away suppressing the hyperactive liver, the function of reducing phlegm and invigorating blood circulation, and the treatment of the disease such as dizzy that is mainly used in that hypertension, hyperlipemia and excessive rising of liver-YANG cause, production technology is simple, and raw material is easily gone, and can make various pharmaceutical dosage forms.Be a kind of determined curative effect, safe ready, little, the cheap pure traditional Chinese compound medicine of side effect.
The specific embodiment
Embodiment 1:
Get following crude drug by weight ratio: Folium Ilicis hainanensis 100g, Folium Notoginseng 100g, Semen Cassiae 100g, Radix Paeoniae Alba 100g, Pericarpium Citri Reticulatae 10g.In above five kinds of Chinese medicine, getting Folium Ilicis hainanensis, to be ground into coarse powder standby; Four flavors such as Folium Notoginseng, Semen Cassiae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae decoct with water three times, add 10 times of amounts of water for the first time, decoct 1 hour, for the second time add 8 times of amounts of water, decocted 1 hour, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.30 (60 ℃), adds above-mentioned Folium Ilicis hainanensis coarse powder, mixing, make granule, drying, pack, promptly.
Embodiment 2:
Get following crude drug by weight ratio: Folium Ilicis hainanensis 1000g, Folium Notoginseng 1000g, Semen Cassiae 1000g, Radix Paeoniae Alba 1000g, Pericarpium Citri Reticulatae 100g.In above five kinds of Chinese medicine, getting Folium Ilicis hainanensis, to be ground into coarse powder standby; Four flavors such as Folium Notoginseng, Semen Cassiae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae decoct with water three times, add 10 times of amounts of water for the first time, decoct 1 hour, for the second time add 8 times of amounts of water, decocted 1 hour, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.30 (60 ℃), adds above-mentioned Folium Ilicis hainanensis coarse powder, mixing, make granule, drying, pack, promptly.
Embodiment 3:
Get following crude drug by weight ratio: Folium Ilicis hainanensis 1600g, Folium Notoginseng 1600g, Semen Cassiae 1600g, Radix Paeoniae Alba 1600g, Pericarpium Citri Reticulatae 160g.In above five kinds of Chinese medicine, getting Folium Ilicis hainanensis, to be ground into coarse powder standby; Four flavors such as Folium Notoginseng, Semen Cassiae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae decoct with water three times, add 10 times of amounts of water for the first time, decoct 1 hour, for the second time add 8 times of amounts of water, decocted 1 hour, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.30 (60 ℃), adds above-mentioned Folium Ilicis hainanensis coarse powder, mixing, make granule, drying, pack, promptly.
Embodiment 4:
Get following crude drug by weight ratio: Folium Ilicis hainanensis 1600g, Folium Notoginseng 1600g, Semen Cassiae 1600g, Radix Paeoniae Alba 1600g, Pericarpium Citri Reticulatae 160g.In above five kinds of Chinese medicine, get Folium Ilicis hainanensis and be ground into coarse powder, add 70% alcohol reflux 2 times, merge extractive liquid, filters, after reclaiming ethanol, add 4～8 times of water gaging dissolvings, filter, filtrate is passed through macroporous resin adsorption, collect 30%～70% ethanol elution, concentrate, drying is pulverized the powder that gets dry extract; Four flavors such as Folium Notoginseng, Semen Cassiae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae decoct with water three times, add 10 times of amounts of water for the first time, decoct 1 hour, for the second time add 8 times of amounts of water, decocted 1 hour, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.30 (60 ℃), add above-mentioned Folium Ilicis hainanensis dried cream powder, mixing is made granule, packing, promptly.
Embodiment 5:
Get following crude drug by weight ratio: Folium Ilicis hainanensis 1600g, Folium Notoginseng 1600g, Semen Cassiae 1600g, Radix Paeoniae Alba 1600g, Pericarpium Citri Reticulatae 160g.In above five kinds of Chinese medicine, get Folium Ilicis hainanensis and be ground into coarse powder, add 70% alcohol reflux 2 times, merge extractive liquid, filters, after reclaiming ethanol, add 4～8 times of water gaging dissolvings, filter, filtrate is passed through macroporous resin adsorption, collect 30%～70% ethanol elution, concentrate, drying is pulverized the powder that gets dry extract; Four flavors such as Folium Notoginseng, Semen Cassiae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae decoct with water three times, add 10 times of amounts of water for the first time, decoct 1 hour, for the second time add 8 times of amounts of water, decocted 1 hour, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.30 (60 ℃), add above-mentioned Folium Ilicis hainanensis dried cream powder, mixing is made granule, incapsulate, promptly.
Embodiment 6:
Get following crude drug by weight ratio: Folium Ilicis hainanensis 1600g, Folium Notoginseng 1600g, Semen Cassiae 1600g, Radix Paeoniae Alba 1600g, Pericarpium Citri Reticulatae 160g.In above five kinds of Chinese medicine, get Folium Ilicis hainanensis and be ground into coarse powder, add 70% alcohol reflux 2 times, merge extractive liquid, filters, after reclaiming ethanol, add 4～8 times of water gaging dissolvings, filter, filtrate is passed through macroporous resin adsorption, collect 30%～70% ethanol elution, concentrate, drying is pulverized the powder that gets dry extract; Four flavors such as Folium Notoginseng, Semen Cassiae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae decoct with water three times, add 10 times of amounts of water for the first time, decoct 1 hour, for the second time add 8 times of amounts of water, decocted 1 hour, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.30 (60 ℃), add above-mentioned Folium Ilicis hainanensis dried cream powder, mixing is made granule, compacting is in blocks, promptly.
Embodiment 7:
Get following crude drug by weight ratio: Folium Ilicis hainanensis 2000g, Folium Notoginseng 2000g, Semen Cassiae 2000g, Radix Paeoniae Alba 2000g, Pericarpium Citri Reticulatae 200g.In above five kinds of Chinese medicine, getting Folium Ilicis hainanensis, to be ground into coarse powder standby; Four flavors such as Folium Notoginseng, Semen Cassiae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae decoct with water three times, add 10 times of amounts of water for the first time, decoct 1 hour, for the second time add 8 times of amounts of water, decocted 1 hour, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.20～1.30 (60 ℃), adds above-mentioned Folium Ilicis hainanensis coarse powder, mixing, make granule, drying, pack, promptly.
The Chinese medicine medicinal tea, granule, capsule, the tablet that adopt above technical recipe to make to 360 routine cardiovascular patient clinical practices, have significant curative effect to dizzy and hypertension, the hyperlipemia that causes because of excessive rising of liver-YANG through Guangxi Duo Jia hospital.
The Semen Cassiae Folium Ilicis hainanensis is to the clinical observed result of taking of cardiovascular patient
Claims (3)
1. the Chinese medicine preparation of a blood pressure lowering, blood fat reducing is characterized in that: made by following Chinese medicine raw materials by weight proportion: 100～2000 parts of Folium Ilicis hainanensis, 100～2000 parts of Folium Notoginsengs, 100～2000 parts of Semen Cassiaes, 100～2000 parts of the Radix Paeoniae Albas, 10～200 parts of Pericarpium Citri Reticulataes.
2. according to the Chinese medicine preparation of claim 1, it is characterized in that: make: 1600 parts of Folium Ilicis hainanensis, 1600 parts of Folium Notoginsengs, 1600 parts of Semen Cassiaes, 1600 parts of the Radix Paeoniae Albas, 160 parts of Pericarpium Citri Reticulataes by following Chinese medicine raw materials by weight proportion.
3. according to the preparation method of the Chinese medicine preparation of claim 1, it is characterized in that preparation method is: getting Folium Ilicis hainanensis, to be ground into coarse powder standby; Folium Notoginseng, Semen Cassiae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae decoct with water three times, add 10 times of amounts of water for the first time, decoct 1 hour, for the second time add 8 times of amounts of water, decocted 1 hour, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, it is 1.20～1.30/60 ℃ clear paste that filtrate is concentrated into relative density, add above-mentioned Folium Ilicis hainanensis coarse powder, mixing is made granule, drying, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101144837A CN101693068B (en) | 2009-10-21 | 2009-10-21 | Medicament for lowering blood pressure and blood lipid |
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| CN2009101144837A CN101693068B (en) | 2009-10-21 | 2009-10-21 | Medicament for lowering blood pressure and blood lipid |
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| CN101693068A CN101693068A (en) | 2010-04-14 |
| CN101693068B true CN101693068B (en) | 2011-06-22 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103340255B (en) * | 2013-07-16 | 2015-02-18 | 徐州万国生物能源科技有限公司 | Tea drink |
| CN105494800A (en) * | 2015-12-22 | 2016-04-20 | 桂林双象生物科技有限公司 | Preparation method of Hainan holly leaf and sweet tea extract compound tea |
| CN105475566A (en) * | 2015-12-22 | 2016-04-13 | 桂林双象生物科技有限公司 | Preparation method of Hainan holly leaf and pueraria extract composite tea |
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- 2009-10-21 CN CN2009101144837A patent/CN101693068B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 杨志坚.HPLC法测定祛瘀健脾茶中大黄酚的含量.《广西中医药 》.2004,(第2期),53. * |
| 王海华,石良伟.HPLC测定祛瘀健脾茶中芍药苷的含量.《广西中医学院学报》.2007,第10卷(第3期),68. * |
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