CN104274682A - Traditional Chinese medicine composition for treating coal workers' pneumoconiosis and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating coal workers' pneumoconiosis and preparation method of traditional Chinese medicine composition Download PDF

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CN104274682A
CN104274682A CN201410582474.1A CN201410582474A CN104274682A CN 104274682 A CN104274682 A CN 104274682A CN 201410582474 A CN201410582474 A CN 201410582474A CN 104274682 A CN104274682 A CN 104274682A
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王洪坤
卢连伟
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Abstract

The invention discloses a traditional Chinese medicine composition for treating coal workers' pneumoconiosis and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises main materials and auxiliary materials, wherein the main materials consist of the following traditional Chinese medicines: lignum dalbergiae odoriferae, henry clematis root, echinopsis tubiflora, semen gleditsiae sinensis, luffa seed, persimmon frost, distilled liquid of white canarytree fruit, rhodiola rosea, radix liquiritiae, flos magnoliae liliflorae, szechwan melandrium root, lily radix asteris and flos farfarae; the auxiliary materials are as follows: mushroom polysaccharide, agaric extract and additive. Based on the principle of combining disease diagnosis with syndrome differentiation for Chinese traditional treatment for pneumoconiosis, according to the theory of traditional Chinese medicine, the medicine materials are formulated according to a weight proportion to prepare the traditional Chinese medicine composition which can be used for internally and externally regulating, relieving the emergency, treating both symptoms and root causes for the pneumoconiosis. According to the clinical verification, the traditional Chinese medicine composition is remarkable in curative effect, free of side effect, low in production cost and suitable for the vast low-income people, especially coal workers to use, and quickly becomes effective.

Description

A kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis and preparation method thereof
Technical field
The present invention relates to technical field of Chinese medicines, especially relate to a kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis and preparation method thereof.
Background technology
Coal-worker's pnuemoconiosis (coalminer's pneumoconiosis) means that coal miner sucks the general name of the pulmonary lesion in production environment caused by dust for a long time.Comprise and mine and make coal workman and suck coal pneumoconiosis caused by pure coal dust, account for 10%; Rock out work sucks the pneumosilicosis caused by silicious dust, accounts for less than 10%; And the anthracosilicosis sucked caused by the mixed dust such as coal dust and silicious dust, mainly occur in the mixing work post of not only tunneling but also mining, account for more than 80%, the most common with anthracosilicosis in colliery.After pneumoconiosis is deformed into, dust residual in lung also continues to work with pulmonary alveolar macrophage, though cause pneumoconiosis patients to depart from dust work pathological changes still continue development.
Current treatment pneumoconiosis method comprises Drug therapy and the treatment of capacity lung lavage, Drug therapy has: (1) oxypovidinum, report oxypovidinum in the sixties, to macrophage, there is protective effect, thereafter China all conducts in-depth research its synthesis, toxicity, metabolism, experimental effect and clinical efficacy, think that this medicine can delay the progress of pneumosilicosis, clinical efficacy is satisfied not as the result of zoopery curative effect; (2) tetrandrine: grandly tell Alkaloid for a kind of binodal base is different, finding that there is in the drug screening of zoopery curative effect significantly suppresses collagen fiber to be formed, SM moves back effect to original necessarily inverse in chamber, but withdrawal time is long, then pathological changes has development again.Clinic trial thinks there is certain effect to pneumosilicosis, but side effect has inappetence, feels sick, abdominal distention, skin are itched, skin-color rope calmness, sinus bradycardia, transient serum AIT rising etc.; (3) aluminium porcelain enamelling: China's application aluminium citrate has carried out experimentation and clinic trial, thinks the progress that can delay pneumoconiosis.Lung lavage with large volume of saline is treated, and is the new technique grown up over nearly 20 years, because it can remove dust in part lung, improve symptom and pulmonary function, improve patients ' life quality, enjoy the welcome of extensive patients, but the expenditure of each unit up to ten thousand becomes again the burden of patient.And society has many Coal Workers Pneumoconiosis, they are in the lowermost end of society, there is no medical security, the disadvantaged group being badly in need of relief, therefore, develop determined curative effect, taking convenience, the chinese herbal compound preparation for the treatment of coal-worker's pnuemoconiosis that is with low cost, that have no side effect have important social meaning and economic implications.
Summary of the invention
For above-mentioned present situation, the technical problem that the present invention solves is to provide a kind of determined curative effect, taking convenience, with low cost, the Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis that has no side effect.
Another object of the present invention is to provide a kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis and preparation method thereof.
Technical scheme of the present invention is:
A kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis, comprise major ingredient and adjuvant, described major ingredient is made up of the Chinese medicine of following weight portion: Lignum Dalbergiae Odoriferae 6 ~ 12 parts, Radix Clematidis Henryi 10 ~ 20 parts, Caulis Echinopsis Multiplicis 18 ~ 40 parts, Semen Gleditsiae 12 ~ 18 parts, Semen Luffae 5 ~ 9 parts, Mannosum Kaki 2 ~ 3 parts, Liquor Fructus Caqnarii Distillata 1 ~ 3 part, Radix Rhodiolae 1 ~ 7 part, 1 ~ 4 part, Radix Glycyrrhizae, Flos Magnoliae 3 ~ 9 parts, Radix Melandrii szechuanensis 10 ~ 16 parts, Bulbus Lilii 5 ~ 15 parts, Radix Asteris 2 ~ 12 parts, Flos Farfarae 4 ~ 10 parts; The each component of described adjuvant and weight portion thereof are respectively: mushroom extract 1.5 ~ 2.5 parts, Auricularia extract 0.3 ~ 0.4 part, additive 0.12 ~ 0.2 part.
Further, described mushroom extract is Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer． extracts by the following method with the ratio of 1:1:2:2 and obtains: take fresh Lentinus Edodes in proportion, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer．, be dried to water content 8%, 40 mesh sieves were pulverized with Universalpulverizer, add reflow of alcohol by solid-liquid ratio 1:4 ~ 6 and extract 1 ~ 2h, the filtering residue that sucking filtration obtains adds distilled water by solid-liquid ratio 1:2 ~ 3, 65 DEG C of supersound extraction 30 ~ 50 minutes, ultrasonic is power 400 ~ 800W, filter, filtrate leaves standstill 0.5 ~ 1h, ethanol to the alcohol solubility adding 2 ~ 3 times 95% is 75 ~ 80%, hold over night, centrifugally to be precipitated, drying and crushing crosses 80 mesh sieves, obtain described mushroom extract.
Further, described Auricularia extract extracts by the following method and obtains: black fungus powder is broken into dry powder, pure water is added by the weight ratio of 1:15 ~ 20, mixing, adopt ultrasonic low temperature extracting twice, ensure that the activity of effective ingredient is constant, described ultrasonic power is 1000 ~ 1200W, extraction temperature is 40 ~ 50 DEG C for the first time, extraction time is 20 ~ 30min, second time extraction temperature is 60 ~ 70 DEG C, extraction time is 10 ~ 20min, be extracted liquid, extract is carried out micro-filtration membrane separation and purification, described micro-filtration membrane aperture is 2 ~ 3 μm, mistake film pressure during micro-filtration membrane separation and purification is 0 ~ 5bar, concentrate through reverse osmosis membrane again, spraying dry, sieve, namely Auricularia extract is obtained.
Further, described additive comprises: sodium alginate 0.4 ~ 1.2 part, lycopene 0.03 ~ 0.06 part, trace element-selenium 0.008 ~ 0.02 part, vitamin A 0.005 ~ 0.006 part, vitamin C 0.01 ~ 0.03 part, catechol 0.015 ~ 0.025 part, flavone 0.3 ~ 0.4 part.
The drug effect of the above all components is: Lignum Dalbergiae Odoriferae: pungent; Temperature; Nontoxic.Return liver, spleen, lung, heart channel.Promoting blood circulation to remove blood stasis, hemostasis analgesic therapy, the strongly fragrant gas of a surname's the five internal organs, sending down the abnormal ascending QI, wards off dirty.Main pain in chest and hypochondrium, traumatic injury, wound hemorrhage, and the vomiting stomachache of colic of cold type pain or foul internal resistance.Radix Clematidis Henryi: arduous, temperature, nontoxic.Heat-clearing and toxic substances removing; Eliminating phlegm and relieving cough; Promoting flow of QI and blood; Pain relieving.Main infantile hyperpyrexia infantile convulsion; Cough; Laryngopharynx swelling and pain; Headache; Stomachache; Stomachache; Traumatic injury; Parotitis; Furuncle poison furuncle; Snakebite.Also tracheitis is controlled, furuncle swelling toxin.Caulis Echinopsis Multiplicis: sweet, flat.Reducing swelling and alleviating pain, promoting flow of QI and blood, heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For cough due to lung-heat, hemorrhoid; Snake bite and insect sting is controlled in external, scalds.Semen Gleditsiae: pungent, temperature, slightly poisonous.Wind and heat eliminating; Dissipating phlegm and resolving masses.Control the quick-fried knot of stool, discharging fresh blood stool, dysentery tenesmus, hernia, scrofula, toxic swelling, skin ulcer tinea.Semen Luffae: micro-sweet is flat.Removing heat-phlegm, moisturizes, anthelmintic.Regulation of mental activities lung, controls stranguria caused by urinary stone, for cough with copious phlegm, and ascariasis, constipation.Mannosum Kaki: sweet is cool.Heat clearing away, moisturizes, and reduces phlegm.Control lung-heat type cough, dry pharynx is had sore throat, lung heat clearing, and control haematemesis, spitting of blood, chronic cough, above disappears.Liquor Fructus Caqnarii Distillata: sweet in the mouth; Acid; Puckery; Property is put down.Return lung, stomach, large intestine channel.Lung heat clearing, throat, promoting the production of body fluid to quench thirst.Radix Rhodiolae: sweet, puckery, cold.QI invigorating lung heat clearing; Promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough.Control hemoptysis, spitting of blood, pneumonia is coughed, women leucorrhea.Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Bulbus Lilii; Except containing protein 21.29%, fat 12.43%, reducing sugar 11.47%, starch 1.61%, and calcium, phosphorus, ferrum, every hectogram is containing outside the nutrients such as 1.443 milligrams of vitamin Bs, 21.2 milligrams of vitamin Cs, also containing some special nutritional labelings, as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also to dry in autumn and multiple Seasonal diseases that is that cause has certain preventive and therapeutic effect.The traditional Chinese medical science is said fresh Bulbus Lilii has tranquilizing by nourishing the heart, effect of nourishing the lung to arrest cough.Flos Magnoliae: pungent, temperature.Attach to the lung and stomach meridians.Dispel the wind, sharp nine orifices, clearance arteries and veins, lets out lung sending down the abnormal ascending QI, and promoting the circulation of QI is broken to be stopped up.Radix Melandrii szechuanensis: arduous, cool, slightly poisonous.Switch is sensible, relieving cough and resolving phlegm, clearing heat and freeing strangury, pain relieving.Radix Asteris: nature and flavor: bitter, temperature.Function cures mainly: warming the lung, the therapeutic method to keep the adverse QI flowing downwards, expectorant, cough-relieving.Control cough due to wind and cold's asthma, asthenia coughs vomiting bloody pus, sore throat, dysuria.Cure mainly the burnt leaf of lung to lift, chronic cough sputum mixed with blood, and consumptive lung disease, phlegm dyspnea, quenches one's thirst, and makes lung key have the merit in refrigerant abundant pool.Specially logical lung qi, letting out dirt is greasy, along regulating QI machine, and does not hinder in just, relatively not dry, does not violate again cold and cool.Flos Farfarae; Property and flavor of peppery and warm, nourishing the lung to keep the adverse QI downward, reduce phlegm antitussive.Benefit the five internal organs, sending down the abnormal ascending QI is broken to be moulded, and relieve coughing Zhichuan, dredges throat, washs cardiopulmonary and long moisturizing of holding concurrently.Auricularia: property is sweet, flat, nontoxic.Can fill blood, cooling blood for hemostasis, lung moistening stomach reinforcing, dryness moistening and intestine benefiting, relaxing muscles and tendons and activating QI and blood in the collateral, strong will of making light of one's life by commiting suicide.The diseases such as treatment deficiency of both QI and blood, cough due to deficiency of the lung, puerperal asthenia.Auricularia contains eight necessary seed amino acids of human body and vitamin, has higher nutritive value and certain medical value.Containing acid mucopolysaccharide in Auricularia sporophore, there are the effects such as blood sugar lowering, blood fat reducing, defying age, antiulcer, anti-radiation, antithrombus formation, raising body's immunity, enhancing body resistance against diseases.Auricularia extract is rich in abundant Auricularia polysaccharide, is made up of monosaccharide such as L-fucose, L-arabinose, D-xylose, D-MANNOSE, D-Glucose and glucuronic acids.Sodium alginate: be a kind of natural polysaccharide, there is the stability needed for pharmaceutical preparation adjuvant, dissolubility, viscosity and safety.Mainly on medicament be used as suspending agent, emulsifying agent, sticky dose, the capsule material etc. of microcapsule.Sodium alginate is used as the binding agent of tablet, stabilizing agent.Lycopene: be one of most powerful antioxidant be found in natural plant at present, effect of lycopene scavenging free radicals outclass other carotenoid and vitamin E, its singlet-oxygen quenching speed constant is 100 times of vitamin E, it can effectively preventing because of aging, the various diseases that immunity degradation causes.Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer．, Auricularia extract and trace element-selenium, vitamin A 0.005-0.006, vitamin C 0.01-0.03, catechol 0.015-0.025 and flavone 0.3-0.4 can strengthen body immunity.
Another technical scheme of the present invention is:
A kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis and preparation method thereof, specifically comprises the following steps:
(1) Lignum Dalbergiae Odoriferae is taken by described proportioning, Radix Clematidis Henryi, Caulis Echinopsis Multiplicis, Semen Gleditsiae, Semen Luffae, Radix Rhodiolae, Radix Glycyrrhizae, Flos Magnoliae, Radix Melandrii szechuanensis, Bulbus Lilii, Radix Asteris, Flos Farfarae, mixing, pulverize, 30 ~ 40 DEG C of warm water soaking 30 ~ 50 minutes are added by solid-liquid ratio 1:6 ~ 10, decoct 2 times, each 1 ~ 1.2 hour, filter, merging filtrate, be evaporated to the thick paste that relative density is 1.16 ~ 1.28, treat that temperature is cooled to 40 DEG C, with alcohol settling twice, first time adds dehydrated alcohol makes alcohol content reach 75 ~ 80%, abundant stirring, leave standstill 4 ~ 6 hours, get supernatant, reclaim ethanol, add 3 ~ 4 times of water gagings, leave standstill 10 hours, get supernatant, be evaporated to the thick paste that relative density is 1.15 ~ 1.65, treat that temperature is cooled to 40 DEG C, second time adds ethanol makes alcohol content reach 80 ~ 85%, leave standstill 24 hours, get supernatant, enter alcohol distillation column and reclaim ethanol until medicinal liquid is without alcohol taste, obtain pure medicinal liquid, being condensed into relative density under 70 DEG C of conditions is the thick paste of 1.26 ~ 1.38, spraying dry, be pressed into extract powder, for subsequent use,
(2) fresh Lentinus Edodes is taken in the ratio of 1:1:2:2, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer．, be dried to water content 8%, 40 mesh sieves were pulverized with Universalpulverizer, add reflow of alcohol by solid-liquid ratio 1:4 ~ 6 and extract 1 ~ 2h, the filtering residue that sucking filtration obtains adds distilled water by solid-liquid ratio 1:2 ~ 3, 65 DEG C of supersound extraction 30 ~ 50 minutes, ultrasonic is power 400 ~ 800W, filter, filtrate leaves standstill 0.5 ~ 1h, ethanol to the alcohol solubility adding 2 ~ 3 times 95% is 75 ~ 80%, hold over night, centrifugally to be precipitated, drying and crushing crosses 80 mesh sieves, obtain described mushroom extract, take 1.5 ~ 2.5 parts for subsequent use,
(3) black fungus powder is broken into dry powder, pure water is added by the weight ratio of 1:15 ~ 20, mixing, adopt ultrasonic low temperature extracting twice, ensure that the activity of effective ingredient is constant, described ultrasonic power is 1000 ~ 1200W, extraction temperature is 40 ~ 50 DEG C for the first time, extraction time is 20 ~ 30min, second time extraction temperature is 60 ~ 70 DEG C, extraction time is 10 ~ 20min, be extracted liquid, extract is carried out micro-filtration membrane separation and purification, described micro-filtration membrane aperture is 2 ~ 3 μm, mistake film pressure during micro-filtration membrane separation and purification is 0 ~ 5bar, concentrate through reverse osmosis membrane again, spraying dry, sieve, namely Auricularia extract is obtained, take 0.3 ~ 0.4 part for subsequent use,
(4) by the extract powder that step (1) obtains by described proportioning, and Mannosum Kaki, Liquor Fructus Caqnarii Distillata, mushroom extract, Auricularia extract, sodium alginate, lycopene, trace element-selenium, vitamin A, vitamin C, catechol, flavone merge, obtain mixture, make acceptable dosage form according to pharmacy routine.
Further, described dosage form is tablet, capsule, granule; Realize for enabling above-mentioned dosage form, the acceptable adjuvant of pharmacy need be added, such as: pregelatinized Starch, lactose, carboxymethyl starch sodium, microcrystalline Cellulose, sucrose, magnesium stearate, sodium benzoate, low-substituted hydroxypropyl cellulose, enoxolone etc. when preparing these dosage forms.
The invention has the beneficial effects as follows:
(1) the present invention is based on the differential diagnosis of diseases of Chinese traditional treatment pneumoconiosis and the dialectical principle combined, according to theory of Chinese medical science prescription, select the Chinese herbal medicine of promoting flow of QI and blood: Lignum Dalbergiae Odoriferae, Radix Clematidis Henryi, Caulis Echinopsis Multiplicis, the Chinese herbal medicine of clearing away lung-heat and moistening for dryness: Semen Gleditsiae, Semen Luffae, Mannosum Kaki, Liquor Fructus Caqnarii Distillata, Radix Rhodiolae, Radix Glycyrrhizae, increase the Chinese herbal medicine of pulmonary ventilation function: Flos Magnoliae, Radix Melandrii szechuanensis, delay the Chinese herbal medicine of lung fibrillation progress: Radix Asteris, Flos Farfarae, and improve the Lentinus Edodes of immunity of organisms, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull． Ex Franch.) Singer.extract, Auricularia extract, Bulbus Lilii, sodium alginate, lycopene, trace element-selenium, vitamin A, vitamin C, catechol and flavone, be prepared from according to certain weight proportion.Above drug regimen, inside and outsidely can lead to and adjust, emergency is taken in concurrently, this disease is played to the effect taking stopgap measures and effect a permanent cure.
(2) Chinese medicine composition of the present invention is through clinical verification, evident in efficacy, and instant effect is free from side effects, and production cost is low, is applicable to vast low-income groups, and especially coal worker uses.
Detailed description of the invention
The details of various aspects of the present invention will be able to detailed description hereinafter, and by describing, feature of the present invention, object and advantage will be more obvious.
Embodiment 1:
A kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis, comprise major ingredient and adjuvant, described major ingredient is made up of the Chinese medicine of following weight portion: Lignum Dalbergiae Odoriferae 6 parts, Radix Clematidis Henryi 10 parts, Caulis Echinopsis Multiplicis 18 parts, Semen Gleditsiae 12 parts, Semen Luffae 5 parts, Mannosum Kaki 2 parts, Liquor Fructus Caqnarii Distillata 1 part, Radix Rhodiolae 1 part, 1 part, Radix Glycyrrhizae, Flos Magnoliae 3 parts, Radix Melandrii szechuanensis 10 parts, Bulbus Lilii 5 parts, Radix Asteris 2 parts, Flos Farfarae 4 parts; The each component of described adjuvant and weight portion thereof are respectively: mushroom extract 1.5 parts, Auricularia extract 0.3 part, additive 0.12 part.
Wherein, described mushroom extract is Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer． with the ratio of 1:1:2:2 extract obtain, described additive comprises: sodium alginate 0.4 part, lycopene 0.03 part, trace element-selenium 0.008 part, vitamin A 0.005 part, vitamin C 0.01 part, catechol 0.015 part, flavone 0.3 part.
A kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis and preparation method thereof, specifically comprises the following steps:
(1) Lignum Dalbergiae Odoriferae is taken by described proportioning, Radix Clematidis Henryi, Caulis Echinopsis Multiplicis, Semen Gleditsiae, Semen Luffae, Radix Rhodiolae, Radix Glycyrrhizae, Flos Magnoliae, Radix Melandrii szechuanensis, Bulbus Lilii, Radix Asteris, Flos Farfarae, mixing, pulverize, 30 DEG C of warm water soaking 30 minutes are added by solid-liquid ratio 1:6, decoct 2 times, each 1 hour, filter, merging filtrate, be evaporated to the thick paste that relative density is 1.16, treat that temperature is cooled to 40 DEG C, with alcohol settling twice, first time adds dehydrated alcohol makes alcohol content reach 75%, abundant stirring, leave standstill 4 hours, get supernatant, reclaim ethanol, add 3 times of water gagings, leave standstill 10 hours, get supernatant, be evaporated to the thick paste that relative density is 1.15, treat that temperature is cooled to 40 DEG C, second time adds ethanol makes alcohol content reach 80%, leave standstill 24 hours, get supernatant, enter alcohol distillation column and reclaim ethanol until medicinal liquid is without alcohol taste, obtain pure medicinal liquid, being condensed into relative density under 70 DEG C of conditions is the thick paste of 1.26, spraying dry, be pressed into extract powder, for subsequent use,
(2) fresh Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer． is taken in the ratio of 1:1:2:2, be dried to water content 8%, 40 mesh sieves were pulverized with Universalpulverizer, add reflow of alcohol by solid-liquid ratio 1:4 and extract 1h, the filtering residue that sucking filtration obtains adds distilled water by solid-liquid ratio 1:2,65 DEG C of supersound extraction 30 minutes, ultrasonic is power 400W, and filter, filtrate leaves standstill 0.5h, ethanol to the alcohol solubility adding 2 times 95% is 75%, hold over night, is centrifugally precipitated, and drying and crushing crosses 80 mesh sieves, obtain described mushroom extract, take 1.5 parts for subsequent use;
(3) black fungus powder is broken into dry powder, pure water is added by the weight ratio of 1:15, mixing, adopt ultrasonic low temperature extracting twice, ensure that the activity of effective ingredient is constant, described ultrasonic power is 1000W, extraction temperature is 40 DEG C for the first time, extraction time is 20min, second time extraction temperature is 60 DEG C, extraction time is 10min, be extracted liquid, extract is carried out micro-filtration membrane separation and purification, described micro-filtration membrane aperture is 2 μm, mistake film pressure during micro-filtration membrane separation and purification is 0bar, concentrate through reverse osmosis membrane again, spraying dry, sieve, namely Auricularia extract is obtained, take 0.3 part for subsequent use,
(4) by the extract powder that step (1) obtains by described proportioning, and Mannosum Kaki, Liquor Fructus Caqnarii Distillata, mushroom extract, Auricularia extract, sodium alginate, lycopene, trace element-selenium, vitamin A, vitamin C, catechol, flavone merge, obtain mixture, add 120 parts of pregelatinized Starch, 25 parts of lactose, 6 parts of carboxymethyl starch sodium, granulate, tabletting, make tablet.
Embodiment 2:
A kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis, comprise major ingredient and adjuvant, described major ingredient is made up of the Chinese medicine of following weight portion: Lignum Dalbergiae Odoriferae 9 parts, Radix Clematidis Henryi 15 parts, Caulis Echinopsis Multiplicis 29 parts, Semen Gleditsiae 15 parts, Semen Luffae 7 parts, Mannosum Kaki 2.5 parts, Liquor Fructus Caqnarii Distillata 2 parts, Radix Rhodiolae 4 parts, 2.5 parts, Radix Glycyrrhizae, Flos Magnoliae 6 parts, Radix Melandrii szechuanensis 13 parts, Bulbus Lilii 10 parts, Radix Asteris 7 parts, Flos Farfarae 7 parts; The each component of described adjuvant and weight portion thereof are respectively: mushroom extract 2 parts, Auricularia extract 0.35 part, additive 0.16 part.
Wherein, described mushroom extract is Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer． with the ratio of 1:1:2:2 extract obtain, described additive comprises: sodium alginate 0.8 part, lycopene 0.045 part, trace element-selenium 0.014 part, vitamin A 0.0055 part, vitamin C 0.02 part, catechol 0.02 part, flavone 0.35 part.
A kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis and preparation method thereof, specifically comprises the following steps:
(1) Lignum Dalbergiae Odoriferae is taken by described proportioning, Radix Clematidis Henryi, Caulis Echinopsis Multiplicis, Semen Gleditsiae, Semen Luffae, Radix Rhodiolae, Radix Glycyrrhizae, Flos Magnoliae, Radix Melandrii szechuanensis, Bulbus Lilii, Radix Asteris, Flos Farfarae, mixing, pulverize, 35 DEG C of warm water soaking 40 minutes are added by solid-liquid ratio 1:8, decoct 2 times, each 1.1 hours, filter, merging filtrate, be evaporated to the thick paste that relative density is 1.22, treat that temperature is cooled to 40 DEG C, with alcohol settling twice, first time adds dehydrated alcohol makes alcohol content reach 77.5%, abundant stirring, leave standstill 5 hours, get supernatant, reclaim ethanol, add 3.5 times of water gagings, leave standstill 10 hours, get supernatant, be evaporated to the thick paste that relative density is 1.4, treat that temperature is cooled to 40 DEG C, second time adds ethanol makes alcohol content reach 82.5%, leave standstill 24 hours, get supernatant, enter alcohol distillation column and reclaim ethanol until medicinal liquid is without alcohol taste, obtain pure medicinal liquid, being condensed into relative density under 70 DEG C of conditions is the thick paste of 1.32, spraying dry, be pressed into extract powder, for subsequent use,
(2) fresh Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer． is taken in the ratio of 1:1:2:2, be dried to water content 8%, 40 mesh sieves were pulverized with Universalpulverizer, add reflow of alcohol by solid-liquid ratio 1:5 and extract 1.5h, the filtering residue that sucking filtration obtains adds distilled water by solid-liquid ratio 1:2.5,65 DEG C of supersound extraction 40 minutes, ultrasonic is power 600W, and filter, filtrate leaves standstill 0.75h, ethanol to the alcohol solubility adding 2.5 times 95% is 77.5%, hold over night, is centrifugally precipitated, and drying and crushing crosses 80 mesh sieves, obtain described mushroom extract, take 2 parts for subsequent use;
(3) black fungus powder is broken into dry powder, pure water is added by the weight ratio of 1:17.5, mixing, adopt ultrasonic low temperature extracting twice, ensure that the activity of effective ingredient is constant, described ultrasonic power is 1100W, extraction temperature is 45 DEG C for the first time, extraction time is 25min, second time extraction temperature is 65 DEG C, extraction time is 15min, be extracted liquid, extract is carried out micro-filtration membrane separation and purification, described micro-filtration membrane aperture is 2.5 μm, mistake film pressure during micro-filtration membrane separation and purification is 2.5bar, concentrate through reverse osmosis membrane again, spraying dry, sieve, namely Auricularia extract is obtained, take 0.35 part for subsequent use,
(4) by the extract powder that step (1) obtains by described proportioning, and Mannosum Kaki, Liquor Fructus Caqnarii Distillata, mushroom extract, Auricularia extract, sodium alginate, lycopene, trace element-selenium, vitamin A, vitamin C, catechol, flavone merge, obtain mixture, add 7 parts of microcrystalline Cellulose, 20 portions of sucrose, 0.6 part of magnesium stearate, 0.3 part of sodium benzoate, mixing, encapsulated, make capsule.
Embodiment 3:
A kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis, comprise major ingredient and adjuvant, described major ingredient is made up of the Chinese medicine of following weight portion: Lignum Dalbergiae Odoriferae 12 parts, Radix Clematidis Henryi 20 parts, Caulis Echinopsis Multiplicis 40 parts, Semen Gleditsiae 18 parts, Semen Luffae 9 parts, Mannosum Kaki 3 parts, Liquor Fructus Caqnarii Distillata 3 parts, Radix Rhodiolae 7 parts, 4 parts, Radix Glycyrrhizae, Flos Magnoliae 9 parts, Radix Melandrii szechuanensis 16 parts, Bulbus Lilii 15 parts, Radix Asteris 12 parts, Flos Farfarae 10 parts; The each component of described adjuvant and weight portion thereof are respectively: mushroom extract 2.5 parts, Auricularia extract 0.4 part, additive 0.2 part.
Wherein, described mushroom extract is Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer． with the ratio of 1:1:2:2 extract obtain, described additive comprises: sodium alginate 1.2 parts, lycopene 0.06 part, trace element-selenium 0.02 part, vitamin A 0.006 part, vitamin C 0.03 part, catechol 0.025 part, flavone 0.4 part.
A kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis and preparation method thereof, specifically comprises the following steps:
(1) Lignum Dalbergiae Odoriferae is taken by described proportioning, Radix Clematidis Henryi, Caulis Echinopsis Multiplicis, Semen Gleditsiae, Semen Luffae, Radix Rhodiolae, Radix Glycyrrhizae, Flos Magnoliae, Radix Melandrii szechuanensis, Bulbus Lilii, Radix Asteris, Flos Farfarae, mixing, pulverize, 40 DEG C of warm water soaking 50 minutes are added by solid-liquid ratio 1:10, decoct 2 times, each 1.2 hours, filter, merging filtrate, be evaporated to the thick paste that relative density is 1.28, treat that temperature is cooled to 40 DEG C, with alcohol settling twice, first time adds dehydrated alcohol makes alcohol content reach 80%, abundant stirring, leave standstill 6 hours, get supernatant, reclaim ethanol, add 4 times of water gagings, leave standstill 10 hours, get supernatant, be evaporated to the thick paste that relative density is 1.65, treat that temperature is cooled to 40 DEG C, second time adds ethanol makes alcohol content reach 85%, leave standstill 24 hours, get supernatant, enter alcohol distillation column and reclaim ethanol until medicinal liquid is without alcohol taste, obtain pure medicinal liquid, being condensed into relative density under 70 DEG C of conditions is the thick paste of 1.38, spraying dry, be pressed into extract powder, for subsequent use,
(2) fresh Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer． is taken in the ratio of 1:1:2:2, be dried to water content 8%, 40 mesh sieves were pulverized with Universalpulverizer, add reflow of alcohol by solid-liquid ratio 1:6 and extract 2h, the filtering residue that sucking filtration obtains adds distilled water by solid-liquid ratio 1:3,65 DEG C of supersound extraction 50 minutes, ultrasonic is power 800W, and filter, filtrate leaves standstill 1h, ethanol to the alcohol solubility adding 3 times 95% is 80%, hold over night, is centrifugally precipitated, and drying and crushing crosses 80 mesh sieves, obtain described mushroom extract, take 2.5 parts for subsequent use;
(3) black fungus powder is broken into dry powder, pure water is added by the weight ratio of 1:20, mixing, adopt ultrasonic low temperature extracting twice, ensure that the activity of effective ingredient is constant, described ultrasonic power is 1200W, extraction temperature is 50 DEG C for the first time, extraction time is 30min, second time extraction temperature is 70 DEG C, extraction time is 20min, be extracted liquid, extract is carried out micro-filtration membrane separation and purification, described micro-filtration membrane aperture is 3 μm, mistake film pressure during micro-filtration membrane separation and purification is 5bar, concentrate through reverse osmosis membrane again, spraying dry, sieve, namely Auricularia extract is obtained, take 0.4 part for subsequent use,
(4) by the extract powder that step (1) obtains by described proportioning, and Mannosum Kaki, Liquor Fructus Caqnarii Distillata, mushroom extract, Auricularia extract, sodium alginate, lycopene, trace element-selenium, vitamin A, vitamin C, catechol, flavone merge, obtain mixture, add 90 parts of pregelatinized Starch, 30 portions of sucrose, 0.8 part of low-substituted hydroxypropyl cellulose, 0.3 part of enoxolone, granulate, make granule.
Curative effect:
1. experimental subject: gather clinical Pneumoconiosis Patients 80 example of accepting for medical treatment, wherein man 72 example, female 8 example; The oldest person 56 years old, age reckling only has 23 years old, adopts Chinese medicine composition of the present invention to treat.
2. Therapeutic Method: 80 patients use the embodiment of the present invention 1, embodiment 2, medicament prepared by embodiment 3 at random, its usage and consumption as follows:
(1) tablet: every day three times, each 3 ~ 6, every sheet content of dispersion 0.3 gram, warm water takes;
(2) capsule: every day three times, each serving 2 ~ 4, every content of dispersion 0.5 gram, warm water takes;
(3) granule: every day three times, each 5 ~ 10 grams, warm water takes.
The course for the treatment of: one month be a course for the treatment of, treated for 4 courses for the treatment of altogether.
3. the standard of curative effect evaluation
Cure: symptom and sign are improved completely, and conducting lung X-ray examination inspection is completely normal.Patient is without any bad sensation, happy, in high spirits.
Effective: symptom and sign are significantly improved, conducting lung X-ray examination inspection obviously improves.Patient is substantially without bad sensation, happy, and spirit very well.
Effective: symptom and sign are improved, conducting lung X-ray examination inspection changes.Random thoughts are slightly uncomfortable, but can accept, and mood is better, and energy is more abundant.
Invalid: sign is without any change, and conducting lung X-ray examination checks without changing.
4. therapeutic outcome statistics:
In accepted for medical treatment 29 routine cases, through treatment in 4 months, wherein cure 71 examples, effective 3 examples, effective 4 examples, invalid 2 examples, have no any untoward reaction, total effective rate reaches 97.5%.
5. conclusion: above result display, Chinese medicine composition of the present invention is for pneumoconiosis determined curative effect, safe and effective, has no side effect.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.

Claims (6)

1. treat the Chinese medicine composition of coal-worker's pnuemoconiosis for one kind, it is characterized in that comprising major ingredient and adjuvant, described major ingredient is made up of the Chinese medicine of following weight portion: Lignum Dalbergiae Odoriferae 6 ~ 12 parts, Radix Clematidis Henryi 10 ~ 20 parts, Caulis Echinopsis Multiplicis 18 ~ 40 parts, Semen Gleditsiae 12 ~ 18 parts, Semen Luffae 5 ~ 9 parts, Mannosum Kaki 2 ~ 3 parts, Liquor Fructus Caqnarii Distillata 1 ~ 3 part, Radix Rhodiolae 1 ~ 7 part, 1 ~ 4 part, Radix Glycyrrhizae, Flos Magnoliae 3 ~ 9 parts, Radix Melandrii szechuanensis 10 ~ 16 parts, Bulbus Lilii 5 ~ 15 parts, Radix Asteris 2 ~ 12 parts, Flos Farfarae 4 ~ 10 parts; The each component of described adjuvant and weight portion thereof are respectively: mushroom extract 1.5 ~ 2.5 parts, Auricularia extract 0.3 ~ 0.4 part, additive 0.12 ~ 0.2 part.
2. a kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis as claimed in claim 1, it is characterized in that described mushroom extract is Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer． extracts by the following method with the ratio of 1:1:2:2 and obtains: take fresh Lentinus Edodes in proportion, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer．, be dried to water content 8%, pulverize, add reflow of alcohol by solid-liquid ratio 1:4 ~ 6 and extract 1 ~ 2h, the filtering residue that sucking filtration obtains adds distilled water by solid-liquid ratio 1:2 ~ 3, 65 DEG C of supersound extraction 30 ~ 50 minutes, ultrasonic is power 400 ~ 800W, filter, adding 2 ~ 3 times of ethanol to alcohol solubility is 75 ~ 80%, hold over night, centrifugally to be precipitated, drying and crushing, obtain described mushroom extract.
3. a kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis as claimed in claim 1, it is characterized in that described Auricularia extract extracts by the following method and obtains: black fungus powder is broken into dry powder, pure water is added by the weight ratio of 1:15 ~ 20, mixing, adopt ultrasonic low temperature extracting twice, described ultrasonic power is 1000 ~ 1200W, extraction temperature is 40 ~ 50 DEG C for the first time, extraction time is 20 ~ 30min, second time extraction temperature is 60 ~ 70 DEG C, extraction time is 10 ~ 20min, be extracted liquid, extract is carried out micro-filtration membrane separation and purification, again through concentrated, spraying dry, sieve, namely Auricularia extract is obtained.
4. a kind of Chinese medicine composition for the treatment of coal-worker's pnuemoconiosis as claimed in claim 1, is characterized in that described additive comprises: sodium alginate 0.4 ~ 1.2 part, lycopene 0.03 ~ 0.06 part, trace element-selenium 0.008 ~ 0.02 part, vitamin A 0.005 ~ 0.006 part, vitamin C 0.01 ~ 0.03 part, catechol 0.015 ~ 0.025 part, flavone 0.3 ~ 0.4 part.
5. a kind of preparation method for the treatment of the Chinese medicine composition of coal-worker's pnuemoconiosis as described in Claims 1 to 4 any one, is characterized in that comprising the following steps:
(1) Lignum Dalbergiae Odoriferae is taken by described proportioning, Radix Clematidis Henryi, Caulis Echinopsis Multiplicis, Semen Gleditsiae, Semen Luffae, Radix Rhodiolae, Radix Glycyrrhizae, Flos Magnoliae, Radix Melandrii szechuanensis, Bulbus Lilii, Radix Asteris, Flos Farfarae, mixing, add 30 ~ 40 DEG C of warm water soaking 30 ~ 50 minutes, decoct 2 times, each 1 ~ 1.2 hour, filter, merging filtrate, be evaporated to the thick paste that relative density is 1.16 ~ 1.28, treat that temperature is cooled to 40 DEG C, with alcohol settling twice, get supernatant, enter alcohol distillation column recovery ethanol and obtain pure medicinal liquid, being condensed into relative density under 70 DEG C of conditions is the thick paste of 1.26 ~ 1.38, spraying dry, be pressed into extract powder, for subsequent use,
(2) fresh Lentinus Edodes, mushroom, Hericium erinaceus (Bull. Ex Fr.) Pers., Volvariella volvacea (Bull.Ex Franch.) Singer． is taken in the ratio of 1:1:2:2, be dried to water content 8%, pulverize, add reflow of alcohol by solid-liquid ratio 1:4 ~ 6 and extract 1 ~ 2h, the filtering residue that sucking filtration obtains adds distilled water by solid-liquid ratio 1:2 ~ 3,65 DEG C of supersound extraction 30 ~ 50 minutes, ultrasonic is power 400 ~ 800W, filter, adding 2 ~ 3 times of ethanol to alcohol solubility is 75 ~ 80%, hold over night, centrifugally to be precipitated, drying and crushing, obtains described mushroom extract, take 1.5 ~ 2.5 parts for subsequent use;
(3) black fungus powder is broken into dry powder, pure water is added by the weight ratio of 1:15 ~ 20, mixing, adopt ultrasonic low temperature extracting twice, described ultrasonic power is 1000 ~ 1200W, first time, extraction temperature was 40 ~ 50 DEG C, and extraction time is 20 ~ 30min, and second time extraction temperature is 60 ~ 70 DEG C, extraction time is 10 ~ 20min, be extracted liquid, extract is carried out micro-filtration membrane separation and purification, then through concentrated, spraying dry, sieve, namely obtain Auricularia extract, take 0.3 ~ 0.4 part for subsequent use;
(4) by extract powder that step (1) obtains, and Mannosum Kaki, Liquor Fructus Caqnarii Distillata, mushroom extract, Auricularia extract, sodium alginate, lycopene, trace element-selenium, vitamin A, vitamin C, catechol, flavone merge, obtain mixture, make acceptable dosage form according to pharmacy routine.
6. a kind of preparation method for the treatment of the Chinese medicine composition of coal-worker's pnuemoconiosis as claimed in claim 5, is characterized in that described dosage form is tablet, capsule, granule; For enabling above-mentioned dosage form realize, the acceptable adjuvant of pharmacy need be added when preparing these dosage forms: pregelatinized Starch, lactose, carboxymethyl starch sodium, microcrystalline Cellulose, sucrose, magnesium stearate, sodium benzoate, low-substituted hydroxypropyl cellulose, enoxolone.
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