NL2037306A - A nutritional product for clearing and protecting the lungs and a preparation method thereof - Google Patents
A nutritional product for clearing and protecting the lungs and a preparation method thereof Download PDFInfo
- Publication number
- NL2037306A NL2037306A NL2037306A NL2037306A NL2037306A NL 2037306 A NL2037306 A NL 2037306A NL 2037306 A NL2037306 A NL 2037306A NL 2037306 A NL2037306 A NL 2037306A NL 2037306 A NL2037306 A NL 2037306A
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- parts
- lungs
- lung
- protecting
- food product
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Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention discloses a nutritional product for clearing and protecting the lungs and a preparation method thereof. The nutritional product includes the following raw materials 5 in parts by weight: 45-55 parts of aster, 40-50 parts of loquat leaves, and 30-45 parts of Fritillaria fritillary. ‚ 25-35 parts of Ophiopogon japonicus, 20-30 parts of Polygonatum odoratum, 15-30 parts of coix seed, 15-30 parts of Tremella fuciforrnis, 15-24 parts of Polygala, 10-16 parts of Platycodon, 10-16 parts of Luo Han Guo, 5-5 parts of White Poria. 15 parts, lily 3-12 parts, licorice 5-10 parts, sweet almond 3-10 parts, ginkgo l- 10 10 parts, honey 1-5 parts, ginseng 0.5-3 parts, Cordyceps militaris 0.5-5 parts. The raw materials of the nutritional product have a synergistic effect. Comprehensive conditioning from multiple points such as the lungs, liver, heart, kidney, spleen, stomach, etc. can enhance the effects of nourishing yin and moistening the lungs, clearing away heat and detoxification, eliminating phlegm and relieving cough. , can 15 improve the therapeutic effect, at the same time, after patients use this nutritional product, systemic symptoms such as cough, phlegm, itchy throat and chest tightness have basically disappeared. The total treatment effectiveness is as high as 95%, which can significantly improve patients' symptoms and improve their quality of life.
Description
A nutritional product for clearing and protecting the lungs and a preparation method thereof
The present invention relates to the technical field of nutrition and health care, and more specifically to a nutritional product for clearing and protecting the lungs and a preparation method thereof.
The main physiological function of the lungs is to control qi and breathe, and play a large role in the transformation of vitality and water metabolism in the human body. For example, "Su Wen. Different Treatise on Meridians" says: "The meridian qi returns to the lungs, and the lungs move towards the hundred meridians, and the essence is transferred to the skin." It also says: "The spleen disperses the essence, returns to the lungs, regulates the water channels, and the five meridians run in parallel." The theory of traditional Chinese medicine believes that, the lung is a delicate organ, the taiyin in the yang, the outside controls the fur of the body, and the inside is the canopy of the five internal organs. If the function is abnormal, the main clinical manifestations are deficiency and excess. Deficiency syndrome is mainly caused by Qi deficiency and Yin deficiency. Qi deficiency is mostly caused by long-term illness or being burdened by diseases of other organs. Yin deficiency is mostly caused by depletion of body fluids and loss of nourishment of the lungs. Syndrome is mostly caused by phlegm, turbid water, and internal dampness. It is caused by accumulation, cold evil external beam and evil heat taking possession of the lungs. If the lung qi is not properly purified, coughing or even wheezing will occur, which will not heal over time, often leading to symptoms such as deficiency of both qi and yin. Therefore, cough and asthma, sticky phlegm, and full chest and hypochondrium should be treated by purging the lungs to reduce fire, regulating the lungs and reducing phlegm; long-term coughing damages yin or late stage of febrile disease, or lack of qi and yin in the lungs and internal burning due to deficient heat. Moisturizing and descending symptoms should be treated by nourishing yin and moistening the lungs.
In the prior art, patent number CN105477324A discloses a traditional Chinese medicine for treating cough, which is composed of licorice, almond, tangerine peel, Polygonatum odoratum, aster, Schisandra chinensis and Radix Pseudostellariae. Although it can achieve the effect of relieving cough, the traditional Chinese medicine composition The effect of nourishing yin and clearing the lungs is insufficient. Patent No.
CN103690592A discloses a throat-clearing and lung-moistening composition, which is composed of dianchihua, butterfly fruit, black olive, licorice, and Luo Han Guo. It mainly reduces swelling and pain, relieves cough and reduces phlegm, but cannot nourish yin and nourish the lungs. Effect.
Therefore, how to provide a nutritional product that can reduce phlegm and relieve cough while also having the effect of clearing and protecting the lungs is an urgent problem that those skilled in the art need to solve.
In view of this, the present invention provides a lung-clearing and lung-protecting nutritional product and a preparation method thereof.
In order to achieve the above objects, the present invention adopts the following technical solutions:
A nutritional product for clearing and protecting the lungs, including raw materials with the following weight fractions: 45-55 parts of aster, 40-50 parts of loquat leaves, 30-45 parts of Fritillaria fritillary, 25-35 parts of Ophiopogon japonicus, and 20-30 parts of
Polygonatum odorifera. 15-30 parts of coix seed, 15-30 parts of white fungus, 15-24 parts of polygala root, 10-16 parts of platycodon, 10-16 parts of monk fruit, 5-15 parts of white poria, 3-12 parts of lily, 5-10 parts of licorice 3-10 parts of sweet almond, 1-10 parts of ginkgo, 1-5 parts of honey, 0.5-3 parts of ginseng, 0.5-5 parts of Cordyceps militaris.
Preferably, the nutritional product includes raw materials with the following weight fractions: 52 parts of aster, 43 parts of loquat leaves, 34 parts of Fritillaria fritillary, 27 parts of Ophiopogon japonicus, 20 parts of Polygonatum odorifera, 17 parts of Coix seed, 21 parts of Tremella fuciformis, and 18 parts of Polygala root. 14 parts of platycodon, 16 parts of monk fruit, 7 parts of white poria, 9 parts of lily, 8 parts of licorice, 5 parts of sweet almond, 4 parts of ginkgo, 3 parts of honey, 2 parts of ginseng, and 1 part of cordyceps.
Preferably, the nutritional product includes raw materials with the following weight fractions: 55 parts of aster, 40 parts of loquat leaves, 40 parts of Fritillaria fritillary, 35 parts of Ophiopogon japonicus, 27 parts of Polygonatum odorifera, 15 parts of Coix seed, 27 parts of Tremella fuciformis, and 15 parts of Polygala root. 10 parts of platycodon, 14 parts of monk fruit, 5 parts of white poria, 12 parts of lily, 5 parts of licorice, 8 parts of sweet almond, 1 part of ginkgo, 5 parts of honey, 0.5 part of ginseng, and 3 parts of cordyceps militaris.
Preferably, the nutritional product includes raw materials with the following weight fractions: 45 parts of aster, 50 parts of loquat leaves, 30 parts of Fritillaria fritillary, 25 parts of Ophiopogon japonicus, 30 parts of Polygonatum odorifera, 24 parts of Coix seed, 15 parts of Tremella fuciformis, 24 parts of Polygala root 16 parts of platycodon, 10 parts of Luo Han Guo, 15 parts of Poria, 3 parts of lily, 10 parts of licorice, 3 parts of sweet almond, 10 parts of ginkgo, 1 part of honey, 1 part of ginseng, and 2 parts of
Cordyceps militaris.
As the same inventive concept as the above technical solution, the present invention also claims a preparation method of a lung-clearing and lung-protecting nutritional product, which includes the following steps: (1) Weigh the raw materials according to the above weight parts and set aside; (2) Take aster, loquat leaves, Fritillaria chuanensis, Ophiopogon japonicus,
Polygonatum odoratum, Coix seed, Tremella fungus, ginseng and Cordyceps militaris and place them in a decoction pot, add water to soak, reflux and extract, filter to obtain filtrate A;
(3) Take Polygala root, Platycodon grandiflorum, Luo Han Guo, licorice, white Poria, lily, licorice, sweet almond and ginkgo in a decoction pot, add water to soak, reflux and extract, filter to obtain filtrate B; (3) Mix filtrate A and filtrate B and boil for 0.5-1h to obtain decoction liquid C; (4) Concentrate the filtrate C to a clear paste with a relative density of 1.1-1.3 at 60- 70°C, and let it stand to obtain a concentrated solution; (5) Filter the concentrated solution, add honey and mix well, filter, pot, and sterilize to obtain the nutritional product.
Preferably, in step (2), the amount of water added is 8-10 times the total amount of medicinal materials in this step.
Preferably, in steps (2)-(3), the soaking time is 0.5-1h, and the extraction time is 1-2h.
Preferably, in step (3), the amount of water added is 6-8 times the total amount of medicinal materials in this step.
As the same inventive concept as the above technical solution, the present invention also claims the application of the nutritional product in the preparation of medicines for moistening the lungs, relieving cough and eliminating phlegm.
As the same inventive concept as the above technical solution, the present invention also claims the application of the nutritional product in preparing health products or foods with the effect of nourishing yin and moistening the lungs.
The pharmacological effects of each raw material in the present invention are as follows:
Aster: bitter in taste, warm in nature, moistening the lungs and lowering qi, eliminating phlegm and relieving cough; used for asthma and cough with excessive phlegm, chronic cough, and hemoptysis due to exertion; Aster can significantly increase bronchial secretion and has a good expectorant effect.
Loquat leaf: bitter in taste, slightly cold in nature, returns to the lung and stomach meridian, has the effects of clearing the lungs and relieving cough, soothing the stomach, diuresis, and quenching thirst. It is used to treat cough due to lung heat and yellow phlegm; it contains sesquiterpenes and bitter almonds Glycosides and other ingredients have the effects of clearing the lungs and relieving cough, reducing qi and relieving vomiting.
Fritillaria fritillary: bitter, sweet, slightly cold in nature, returns to the lungs and heart meridian, has the effects of clearing away heat and resolving phlegm, moistening the 5 lungs and relieving coughs, dispersing stagnation and reducing swelling; used for chronic cough due to fatigue, cough due to lung heat and dryness, and vomiting pus due to lung abscess. , scrofula, tuberculosis, mastitis, sores;
Ophiopogon japonicus: sweet, slightly bitter, slightly cold in nature, returns to the stomach, lungs, and heart meridians. It has the effects of nourishing yin and moistening the lungs, benefiting the stomach and promoting body fluid, clearing the heart and removing troubles. It is used for dry cough due to lung dryness, consumptive cough caused by yin deficiency, and sore throat. Symptoms include pain, fluid and wound thirst, internal heat quenching thirst, irritability and insomnia, intestinal dryness and constipation.
Polygonatum odoratum: sweet in taste, slightly cold in nature, returns to the lung meridian and stomach meridian, has the effects of nourishing yin and moisturizing, producing body fluid and quenching thirst. It is used for lung and stomach yin injuries, dry-heat cough, throat thirst, internal heat quenching thirst, etc. As a tonic medicine, it mainly treats heat diseases that damage yin, dry cough due to deficiency of heat, heart disease, diabetes, tuberculosis and other diseases. It can also be used as high-grade nourishing food, delicacies and drinks, and has health care effects.
Coix Seed: sweet, light, cool in nature, returns to the spleen, stomach, and lung meridian, has the effects of strengthening the spleen and expelling dampness, clearing away heat and pus, removing paralysis, and diuresis; used for edema and athlete's foot, diarrhea due to lack of food, and damp paralysis and spasm. Lung abscess, intestinal abscess.
Tremella fungus: sweet, light, neutral in nature, returns to the lung, stomach, and kidney meridian, has the effects of nourishing yin and moistening the lungs, nourishing the body fluid, replenishing gi and blood, and is used for cough due to fatigue, blood in the phlegm, thirst due to lack of body fluid; Physical weakness after illness; shortness of breath and fatigue.
Polygala: bitter and pungent in taste, warm in nature, and returns to the heart, kidney, and lung meridians. It has the effects of calming the mind and improving the mind, eliminating phlegm and reducing swelling. It is used for heart-kidney disharmony, insomnia, dreaminess, forgetfulness, palpitations, confusion, and unpleasant expectoration. Sores, swelling and poison, breast swelling and pain.
Platycodon: bitter, pungent, neutral in nature, returns to the lung meridian, has the effects of clearing the lungs and removing phlegm, soothing the throat and draining pus. It is used to treat cough with excessive phlegm, chest and diaphragm fullness and tightness, sore throat and hoarse voice, and pulmonary gangrene and pus.
Luo Han Guo: Sweet in taste and cool in nature, it returns to the lungs and large intestine meridian. It has the effects of moistening the lungs and relieving coughs, producing body fluids and quenching thirst, and moisturizing the intestines and laxatives. It is suitable for coughs caused by lung heat or dryness, whooping cough, and thirst caused by summer heat. In addition, other The fruit has high nutritional value and is rich in vitamin
C, glycosides, fructose, glucose, protein, lipids, etc.
White Poria: sweet, light, neutral in nature, and returns to the heart, spleen, lung, and kidney meridian. Poria contains Poria polysaccharide, B-Poria polysaccharide, poria acid, lecithin, sterols and other substances. It has anti-toxic, anti-cancer, and diuretic properties. , it has the effect of strengthening the spleen and resolving phlegm, calming the heart and calming the nerves. It is used for cough caused by phlegm-dampness, phlegm-dampness entering the collaterals, and diarrhea due to spleen deficiency.
Lily: sweet, slightly bitter, slightly cold in nature, returns to the heart and lung meridian, has the effects of nourishing yin and moistening the lungs, clearing the heart and calming the nerves; used for chronic cough due to yin deficiency, blood in the phlegm, late stage of febrile disease, and residual heat that has not been cleared.
Licorice: tonify the spleen and replenish qi, clear away heat and detoxify, eliminate phlegm and relieve cough, relieve pain and relieve pain, and reconcile various medicines; used for weak spleen and stomach, fatigue and weakness, palpitations and shortness of breath, cough with excessive phlegm, acute pain in the epigastrium and limbs, and carbuncle and sores.
Sweet almond: sweet in taste, calm in nature, returns to the lungs and large intestine meridian, has the effects of moistening the lungs, relieving coughs and relieving asthma, strengthening the spleen and moistening the intestines and laxative. It is used for fatigue cough, asthma, chest and abdominal tightness, intestinal dryness and constipation.
Ginkgo: sweet, bitter, neutral in nature, returns to the lung and kidney meridian, has the effects of eliminating phlegm and relieving cough, moistening the lungs and relieving asthma; the ginkgo acid and ginkgo phenol contained in the ginkgo have anti- tuberculosis effects and are helpful in improving the symptoms of tuberculosis.
Symptoms such as fever, night sweats, cough, hemoptysis, and loss of appetite caused by tuberculosis have a certain role.
Ginseng: sweet, slightly bitter, slightly warm in nature, returns to the lung and spleen meridian, has the effects of soothing the throat and reducing phlegm, tonifying the spleen and lungs, promoting fluid production, calming the nerves and improving intelligence.
It is used for Qi deficiency, weak pulse, and spleen deficiency. Qi subsidence, lung deficiency, wheezing and coughing, shortness of breath and fatigue.
Cordyceps militaris: Returns to the lung and kidney meridian, and has the effects of nourishing the lungs and relieving asthma, strengthening the spleen and calming the mind, strengthening Qi and improving immunity; the glutamic acid contained in
Cordyceps militaris has an immunosuppressive effect, and the cordycepin contained in
Cordyceps militaris can effectively reduce Pulmonary fibrosis, improve lung tissue structure and fibrosis pathological changes.
It can be seen from the above technical solution that compared with the prior art, the present invention provides a lung-clearing and lung-protecting nutritional product and a preparation method thereof, with beneficial effects: (1) The nutritional product of the present invention is made of pure traditional Chinese medicine in a reasonable proportion, and is in line with the compatibility of traditional
Chinese medicine and modern pharmacology. Aster moistens the lungs and lowers qi, eliminates phlegm and relieves coughs, focusing on nourishing yin; loquat leaves clears the lungs and relieves coughs, harmonizes the stomach, diuresis, and quenches thirst. It is used for coughs caused by lung heat and yellow phlegm; Fritillaria fritillaris clears heat and resolves phlegm, moistens the lungs and relieves coughs. It is mainly used to treat chronic cough due to fatigue, dryness cough due to lung heat, and pus vomiting from lung abscess; Ophiopogon japonicus nourishes yin and moisturizes the lungs, replenishes the stomach and promotes fluid production, Polygonatum odorifera nourishes vin and moisturizes dryness, produces fluid and quenches thirst, and mainly treats dryness and heat cough; Coix seed clears away lung heat and expels fluid.
Purulent, it lowers the intestines and stomach and exudes dampness; Tremella nourishes yin and moisturizes the lungs, nourishes and promotes body fluids, focusing on moistening the lungs; Polygala expelles phlegm and reduces swelling, and 1s mainly used to treat unpleasant expectoration, sores, swelling and poison; Platycodon raises lung qi, which may rise or fall. Suitable for ascending and descending, the Qi flow can be smooth, and coughing can be stopped; Luo Han Guo clears away heat and moisturizes the lungs, relieves coughs, soothes the throat, smooths the intestines and relieves defecation; White Poria clears away heat and detoxifies, strengthens the spleen and resolves phlegm, focusing on resolving phlegm; Lily nourishes yin and moisturizes the lungs, relieves cough and relieves asthma. , clear away heat and detoxify; licorice clears away heat and detoxifies, eliminates phlegm and relieves cough, and can harmonize various medicines; ginseng soothes the throat and resolves phlegm, nourishes the spleen and lungs, focusing on nourishing; Cordyceps militaris nourishes the lungs, relieves asthma, and strengthens qi. The above medicines are used together to comprehensively regulate multiple points such as the lungs, liver, heart, kidneys, spleen, stomach, etc., while enhancing the effects of nourishing yin and moisturizing the lungs, clearing the lungs and moisturizing dryness, eliminating phlegm and relieving cough, and replenishing qi and nourishing yin. It can also enhance the transportation and transformation capabilities of various organs of the human body, enhance the metabolism of the human body, and coordinate the functions of the organs. (2) The raw materials of the nutritional product of the present invention are compatible, are plants with the same origin as medicine and food, have sufficient sources, have no toxic or side effects, are highly safe and suitable for long-term use; and the preparation process is simple and convenient to take. (3) After the patient takes the nutritional product of the present invention, systemic symptoms such as cough, phlegm, itchy throat and chest tightness basically disappear.
The total treatment effectiveness is as high as 95%, which can significantly improve the patient's symptoms and improve their quality of life.
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all the embodiments.
Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present invention.
Example 1
A nutritional product for clearing and protecting the lungs, including the following raw materials by weight: 52 parts of aster, 43 parts of loquat leaves, 34 parts of Fritillaria fritillary, 27 parts of Ophiopogon japonicus, 20 parts of Polygonatum odorifera, 17 parts of Coix seed, and 19 parts of Tremella fuciformis. , 18 parts Polygala root, 14 parts
Platycodon grandiflorum, 16 parts Luo Han Guo, 7 parts White Poria, 9 parts Lily, 8 parts Licorice, 5 parts sweet almond, 4 parts Ginkgo, 3 parts honey, 2 parts ginseng, 1 part Cordyceps militaris.
The preparation method is as follows: (1) Weigh the raw materials according to the above weight parts and set aside;
(2) Take aster, loquat leaves, Fritillaria chuanensis, Ophiopogon japonicus,
Polygonatum odorifera, coix seed, Tremella fungus, ginseng and Cordyceps militaris in a decoction pot, add 9 times the water and soak for 0.6h, reflux and extract for 1.5h, filter Obtain filtrate A; (3) Take polygala root, platycodon, mangosteen, licorice, white tuckahoe, lily, licorice, sweet almond and ginkgo in a decoction pot, add 7 times the water and soak for 0.6h, reflux and extract for 1.5h, filter to obtain filtrate B, (3) Mix filtrate A and filtrate B and boil for 0.5 hours to obtain decoction liquid C; (4) Concentrate the filtrate C to a clear paste with a relative density of 1.1 at 70°C, and let it stand to obtain a concentrated solution; (5) Filter the concentrated solution, add honey and mix well, filter, pot, and sterilize to obtain the nutritional product.
Example 2
A nutritional product for clearing and protecting the lungs, including raw materials with the following weight fractions: 55 parts of aster, 40 parts of loquat leaves, 40 parts of
Fritillaria fritillary, 35 parts of Ophiopogon japonicus, 27 parts of Polygonatum odorifera, 15 parts of Coix seed, and 27 parts of Tremella fuciformis. , 15 parts of polygala root, 10 parts of platycodon, 14 parts of Luo Han Guo, 5 parts of white Poria, 12 parts of lily, 5 parts of licorice, 8 parts of sweet almond, 1 part of ginkgo, 5 parts of honey, 0.5 part of ginseng, and 3 parts of Cordyceps militaris.
The preparation method is as follows: (1) Weigh the raw materials according to the above weight parts and set aside; (2) Take aster, loquat leaves, Fritillaria chuanensis, Ophiopogon japonicus,
Polygonatum odoratum, coix seed, Tremella fungus, ginseng and Cordyceps militaris and put them into a decoction pot, add 9 times the water and soak for 1 hour, reflux and extract for 2 hours, filter to obtain the filtrate A; (3) Take polygala root, Platycodon grandiflorum, Luo Han Guo, licorice, white Poria, lily, licorice, sweet almond and ginkgo in a decoction pot, add 6 times the water and soak for 1 hour, reflux and extract for 2 hours, filter to obtain filtrate B;
(3) Mix filtrate A and filtrate B and boil for 1 hour to obtain decoction liquid C; (4) Concentrate the filtrate C to a clear paste with a relative density of 1.3 at 60°C, and let it stand to obtain a concentrated solution; (5) Filter the concentrated solution, add honey and mix well, filter, pot, and sterilize to obtain the nutritional product.
Example 3
A nutritional product for clearing and protecting the lungs, including raw materials with the following weight fractions: 45 parts of aster, 50 parts of loquat leaves, 30 parts of
Fritillana fritillary, 25 parts of Ophiopogon japonicus, 30 parts of Polygonatum odorifera, 30 parts of Coix seed, and 21 parts of Tremella fuciformis. , 24 parts of
Polygala, 16 parts of Platycodon, 10 parts of Luo Han Guo, 15 parts of Poria, 3 parts of lily, 10 parts of licorice, 3 parts of sweet almond, 10 parts of ginkgo, 1 part of honey, 1 part of ginseng, 2 parts of Cordyceps militaris.
The preparation method is as follows: (1) Weigh the raw materials according to the above weight parts and set aside; (2) Take aster, loquat leaves, Fritillaria chuanensis, Ophiopogon japonicus,
Polygonatum odorifera, coix seed, Tremella fungus, ginseng and Cordyceps militaris and place them in a decoction pot, add 10 times of water and soak for 0.8h, reflux and extract for 1h, and filter to obtain Filtrate A; (3) Take polygala root, Platycodon grandiflorum, Luo Han Guo, licorice, white Poria, lily, licorice, sweet almond and ginkgo in a decoction pot, add 8 times of water and soak for 0.8h, reflux and extract for 1h, filter to obtain filtrate B: (3) Mix filtrate A and filtrate B and boil for 0.8 hours to obtain decoction liquid C; (4) Concentrate the filtrate C to a clear paste with a relative density of 1.2 at 65°C, and letit stand to obtain a concentrated solution; (5) Filter the concentrated solution, add honey and mix well, filter, pot, and sterilize to obtain the nutritional product.
Example 4
A nutritional product for clearing and protecting the lungs, including raw materials with the following weight fractions: 48 parts of aster, 46 parts of loquat leaves, 37 parts of
Fritillaria fritillary, 32 parts of Ophiopogon japonicus, 23 parts of Polygonatum odorifera, 24 parts of Coix seed, and 30 parts of Tremella fuciformis. , 20 parts
Polygalaceae, 12 parts Platycodon, 12 parts Luo Han Guo, 11 parts White Poria, 6 parts
Lily, 6 parts Licorice, 10 parts sweet almond, 8 parts Ginkgo, 2 parts honey, 3 parts ginseng, 5 parts Cordyceps militaris.
The preparation method is the same as Example 1.
Comparative example 1
A nutritional product for clearing and protecting the lungs, including the following raw materials by weight: 60 parts of aster, 55 parts of loquat leaves, 25 parts of Fritillaria fritillary, 22 parts of Ophiopogon japonicus, 32 parts of Polygonatum odorifera, 13 parts of Coix seed, and 10 parts of Tremella fuciformis. , 13 parts of polygala root, 18 parts of platycodon, 10 parts of monk fruit, 3 parts of white poria, 15 parts of lily, 12 parts of licorice, 11 parts of sweet almond, 14 parts of ginkgo, 3 parts of honey, 4 parts of ginseng, and 0.3 parts of cordyceps militaris.
The preparation method is the same as Example 1.
Comparative example 2
Compared with Example 1, aster and loquat leaves were removed, and the proportions of the remaining components remained unchanged,
Comparative example 3
Compared with Example 1, Platycodon grandiflorum and Luo Han Guo were removed, and the proportions of the remaining components remained unchanged;
Comparative example 4
Compared with Example 1, loquat leaves and Fritillaria fritillaris were replaced with perilla leaves and Bupleurum leaves respectively, and the proportions of the remaining components remained unchanged,
Comparative example 5
Compared with Example 1, Lily, Poria cocos and Cordyceps militaris were removed, and the proportions of the remaining components remained unchanged.
Test Example 1 Effect of different nutritional products on the expectorant effect of mice
Take 110 healthy ICR mice, weighing 18-229, and randomly divide them into 11 groups, namely blank group, ammonium chloride positive control group (0.5g/kg), and nutritional supplements prepared in Examples 1-4 (3.0g/kg ) and the nutritional supplements (3.0g/kg) prepared in Comparative Examples 1-5. Except for the blank group which was given an equal volume of purified water, the other dosage groups were administered continuously for 7 days according to the above dosage. The dosage volume is 10ml/kg. Fast for 12 hours before the last dose. 0.5 hours after the last dose, 5% phenol red saline solution 10ml/kg was intraperitoneally injected. 0.5h later, the mice were sacrificed by cervical dissection. The tissue around the trachea was peeled off, and the parts from the thyroid cartilage to the tracheal branches were cut. Place a section of trachea into a test tube containing alkaline saline (2ml of saline + 0.1ml of IN sodium hydroxide) solution. After leaving it at room temperature for 2 hours, measure the tracheal eluate at a wavelength of 546nm with a UV-visible spectrophotometer. The absorbance was calculated by using the phenol red standard curve to calculate the phenol red content in the trachea of each mouse, and the measurement results are shown in
Table 1.
Table 1 Effects of different nutritional products on the expectorant effect of mice peen 1) Pe Phenol red concentration
Group Dosage (g/kg) Number (ug/ml) aise |= [we ee Se 0.5 10 2.76 chloride group
Example 3 2.92
Example 4 3 10 2.97
Comparative 3 10 2.01 example 1
Comparative 3 10 1.57 example 2
Comparative 3 10 1.84 example 3
Comparative 3 10 2.09 example 4
Comparative 3 10 1.76 example 5
As can be seen from Table 1, there are extremely significant differences between the nutritional products prepared in Examples 1-4 and the blank control group, indicating that the nutritional products can significantly promote the secretion of phenol red in the trachea of mice, illustrating the nutrition of the present invention. The product has a very good expectorant effect. In Comparative Examples 1-5, when the ratio of raw materials is changed, or one raw material is removed or one raw material is replaced, the nutritional supplement prepared can promote the secretion of phenol red in the trachea of mice, but the difference with the blank group is small. , and compared with the present invention, the phenol red secretion of the mouse trachea was significantly reduced, which shows that the raw material components of the nutritional product of the present invention complement each other and work together.
Test Example 2 Effects of different nutritional products on ammonia-induced cough in mice
Take 100 healthy ICR mice, weighing 18-22g, and randomly divide them into 10 groups, namely the model control group, the nutritional products prepared in Examples 1-4 (3.0g/kg) and the nutritional products prepared in Comparative Examples 1-5 ( 3.0g/kg), except that the model control group was given an equal volume of purified water, the other drug groups were administered the above dosage by gavage continuously for 7 days, and the dosage volume was 10ml/kg. 1 hour after the last administration of each group, mice were placed in an inverted 500ml beaker, 0.3ml of concentrated ammonia solution was injected into 50mg of cotton balls, and then placed in the beaker. Observe and record the cough latency of the mice in each group and the number of mice within 5 minutes. Number of coughs (a typical cough is when the mouse's abdominal muscles contract and its mouth opens wide, accompanied by a coughing sound). The measurement results are shown in Table 2.
Table 2 Effects of different nutrients on ammonia-induced cough in mice
Group Dosage Incubation Smin Times of
Number (g/kg) period (8S) coughs model control 83.4 31.6 group
Comparative 77.8 19.6 3 10 example 1
Comparative 74.2 24.8 3 10 example 2
Comparative 10 71.9 27.1 3 example 3
Comparative 76.0 19.5 3 10 example 4
Comparative 10 72.1 25.7 3 example 5 10 It can be seen from Table 2 that the cough latency of the nutritional supplements prepared in Examples 1-4 can significantly extend the cough latency of mice compared with that of the model control group; the number of coughs within 5 minutes of the
Examples 1-4 group is the same as that of the model control group. It shows that the nutritional products of the present invention can significantly prolong the latent period of ammonia-induced cough in mice and reduce the number of coughs, thereby indicating that the nutritional products of the present invention have obvious antitussive effects. In
Comparative Examples 1-5, when the ratio of raw materials is changed, or one raw material is removed or one raw material is replaced, the nutritional product prepared can reduce the number of coughs in mice within 5 minutes, but it cannot prolong the coughing of mice. Incubation period, it can be shown that the raw material components of the nutritional product of the present invention complement each other and work together.
Test Example 3 Efficacy test of different nutritional products
Select 180 patients with cough and phlegm and similar symptoms, and divide them into 9 groups, with 20 people in each group. They take the nutritional supplements prepared in Examples 1-4 and Comparative Examples 1-5 respectively; drink 3g once a day, After drinking for 7 consecutive days, the scoring standards for clinical symptoms were developed according to the "Guiding Principles for Clinical Research of New Traditional
Chinese Medicines", as shown in Table 3. Total symptom score = cough score + expectoration score + throat itching score + chest tightness score. The measurement results are shown in Table 4.
Table 3 Scoring criteria for clinical symptoms
Frequent or
Intermittent paroxysmal coughing, does not | between light | coughing day
Cough none affect normal life | and heavy and night, and work affecting work and sleep
Sticky phlegm is Sputum with a
Cough up a little
Expectoration | none difficult to cough small amount of phlegm up blood streaks
Obvious, but
Very obvious, does not
Itchy throat none Yes but not obvious will aggravate aggravate or or induce cough induce coughing
Occasional attacks
It feels obvious | Feeling obvious,
Chest are mild and do not none but does not | affecting sleep tightness affect rest or affect sleep or activities activities.
According to the "Guiding Principles for Clinical Research of New Traditional Chinese
Medicines", the efficacy judgment criteria are as follows:
Recovery: After treatment, clinical cough and systemic symptoms basically disappear, and the total symptom score is reduced by >95%;
Markedly effective: clinical cough and systemic symptoms are significantly improved after treatment, and the total symptom score is reduced by 70% or less by <95%;
Effective: clinical cough and systemic symptoms are improved after treatment, and the total symptom score is reduced by 30% or less by <70%;
Ineffective: There is no significant improvement in clinical cough and systemic symptoms after treatment, or even worsening, and the total symptom score is reduced by <30%.
Table 4 Efficacy test results of different nutritional products
Very Total rate of
Recovered Effective Ineffective
Group Effective effectiveness (Cases) (cases) (1) (cases) (%)
Comparative 7 4 3 85 example 1
Comparative 4 5 3 85 example 2
Comparative 1 6 5 75 example 3
Comparative 2 3 10 5 75 example 4
Comparative 9 70 example 5
As can be seen from Table 4, after patients take the nutritional supplements prepared in
Examples 1-4 of the present invention, the total effective rate is as high as 95.0%; while after taking Comparative Examples 1-5, the total effective rate is 85.0%; although taking
Comparative Example 1 The cough symptoms were significantly improved after 5 treatment with the nutritional products prepared in -5, but the therapeutic effects were significantly lower than those of the nutritional products prepared in Examples 1-4 of the present invention.
Each embodiment in this specification is described in a progressive manner. Each embodiment focuses on its differences from other embodiments. The same and similar parts between the various embodiments can be referred to each other.
The above description of the disclosed embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be practiced in other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103690592A (en) | 2013-12-25 | 2014-04-02 | 广西博士海意信息科技有限公司 | Throat clearing and lung moistening composite |
CN105477324A (en) | 2015-12-23 | 2016-04-13 | 文有艺 | Traditional Chinese medicine for treating coughs |
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CN103690592A (en) | 2013-12-25 | 2014-04-02 | 广西博士海意信息科技有限公司 | Throat clearing and lung moistening composite |
CN105477324A (en) | 2015-12-23 | 2016-04-13 | 文有艺 | Traditional Chinese medicine for treating coughs |
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