CN105641168A - Medicine for treating viral hepatitis B and viral hepatitis C and preparation method of medicine - Google Patents

Medicine for treating viral hepatitis B and viral hepatitis C and preparation method of medicine Download PDF

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Publication number
CN105641168A
CN105641168A CN201610094550.3A CN201610094550A CN105641168A CN 105641168 A CN105641168 A CN 105641168A CN 201610094550 A CN201610094550 A CN 201610094550A CN 105641168 A CN105641168 A CN 105641168A
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medicine
viral hepatitis
hepatitis
standby
ethanol
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周华增
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/648—Myriapods, e.g. centipedes or millipedes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

The invention discloses a medicine for treating viral hepatitis B and viral hepatitis C and a preparation method of the medicine. The medicine comprises components in percentage by mass as follows: 5% of ginseng, 7% of largehead atractylodes rhizomes, 7% of black ants, 7% of zaocys dhumnades, 6% of centipedes, 7% of snow of June herb, 10% of Chinese angelica, 5% of Chinese magnoliavine fruits, 10% of spina date seeds, 10% of polyporus umbellatus, 7% of India skullcap, 7% of capillary wormwood herbs, 5% of stringy stonecrop herbs and 7% of golden thread. The medicine is a purely natural medicine for treating viral hepatitis B and viral hepatitis C infectious diseases and is a preparation prepared from effective active ingredients extracted from various natural medicinal materials; the immune function is recovered and hepatitis viruses are effectively cleared through treatment of blood and correction of pathological change of blood, and besides, the medicine directly inhibits the viruses, so that total rehabilitation of a patient is realized.

Description

A kind of medicine treating second, the third viral hepatitis and preparation method thereof
Technical field
The present invention relates to a kind of medicine treating viral hepatitis, belong to technical field of pharmaceuticals, refer in particular to a kind of medicine treating second, the third viral hepatitis and preparation method thereof.
Background technology
Human viral's hepatitis disease divide first, second, third, fourth, penta, heptan etc. six kinds, viral hepatitis disease is China's infection rate and the highest infectious disease of sickness rate. According to statistics, being singly that hepatitis b virus carrier just has people more than 300,000,000, wherein have symptom to account for 10%, about 25% patient is chronic, and 3% patient transfers liver cirrhosis to, and in primary hepatocarcinoma, 90% is above what viral hepatitis caused.
At present, viral hepatitis treatment there is no desirable specific medicament. Be generally adopted composite treatment, can only relieving hepatitis serious symptoms, palliate the agonizing sufferings, it is impossible to eradicate hepatitis virus. It would therefore be highly desirable to develop a kind of safe and effective medicine treating viral hepatitis.
Summary of the invention
It is an object of the invention to overcome deficiency of the prior art and defect, it is provided that treat the medicine of second, the third viral hepatitis, this extract drugs multiple animals and plants medical material effective active composition, improve body function, enhancing immunity, eradicates hepatitis virus, patient can be made to reach the purpose of comprehensive rehabilitation.
Another object of the present invention is to provide the process for preparing medicine of above-mentioned treatment second, the third viral hepatitis.
In order to realize first purpose, present invention techniques below scheme realizes:
A kind of medicine treating second, the third viral hepatitis, it includes the component of following mass percent: Radix Ginseng 5%, the Rhizoma Atractylodis Macrocephalae 7%, Formica fusca 7%, Zaocys 7%, Scolopendra 6%, Serissa foetida 7%, Radix Angelicae Sinensis 10%, Fructus Schisandrae Chinensis 5%, Semen Ziziphi Spinosae 10%, Polyporus 10%, India skullcap 7%, Herba Artemisiae Scopariae 7%, Herba Sedi 5%, Rhizoma Coptidis 7%.
Further, described medicine is hard capsule or granule or tablet or pill or powder.
In order to realize second purpose, present invention techniques below scheme realizes:
A kind of process for preparing medicine treating second, the third viral hepatitis, it includes following steps:
S1, weigh the Rhizoma Atractylodis Macrocephalae, Serissa foetida, Semen Ziziphi Spinosae, Polyporus, India skullcap, Herba Artemisiae Scopariae, Herba Sedi, Rhizoma Coptidis according to formula, said components mixture is ground into coarse powder, crosses 30 mesh sieves, cross drainage by 10 times amount and be made as solvent, use countercurrent extraction method, after being filtered by extracting solution machine by centrifugation, to be concentrated into density be 1.25 in heating, after add 95% ethanol dilution to 60%, wine sinks method, static 24 hours, extract supernatant recovery ethanol and obtain clear paste, dry for standby;
S2, weighing Radix Ginseng, Fructus Schisandrae Chinensis according to formula, co-grinding crosses 100 mesh sieves, obtains fine powder standby;
S3, weigh Formica fusca, Zaocys, Scolopendra, Radix Angelicae Sinensis according to formula, size-reduced one-tenth coarse powder, rear through leaching clear liquid recovery ethanol, obtain fluid extract with 60% ethanol countercurrent extraction, drying is standby;
S4, the prepared product of above-mentioned S1, S2 and S3 is pulverized and mixed, dispensing, stirring, detection, subpackage, obtain pharmaceutical product.
Compared with prior art, it has the beneficial effect that the present invention
The present invention is a kind of pure natural medical treating viral hepatitis hepatitis B, Hepatitis C infections disease, it is that the effective active extracting multiple crude drug becomes the preparation being grouped into, by controlling blood, correct the pathological change of blood, recovering immunologic function, effectively remove hepatitis virus, medicine directly suppresses virus on the other hand, making the comprehensive rehabilitation of patient, the major function of medicine of the present invention is to strengthen immunity, invigorating the spleen and relieving depression of liver-QI, detoxicating, relieving inflammation, blood circulation promoting and blood stasis dispelling.
In order to enable the apparent understanding present invention, the specific embodiment of the present invention described in detail below.
Detailed description of the invention
A kind of medicine treating second, the third viral hepatitis, every 1000 grams of components including following weight: Radix Ginseng 50 grams, the Rhizoma Atractylodis Macrocephalae 70 grams, Formica fusca 70 grams, Zaocys 70 grams, Scolopendra 60 grams, Serissa foetida 70 grams, Radix Angelicae Sinensis 100 grams, Fructus Schisandrae Chinensis 50 grams, Semen Ziziphi Spinosae 100 grams, Polyporus 100 grams, India skullcap 70 grams, Herba Artemisiae Scopariae 70 grams, Herba Sedi 50 grams, Rhizoma Coptidis 70 grams.
The preparation method of said medicine includes following steps:
S1, weigh the Rhizoma Atractylodis Macrocephalae, Serissa foetida, Semen Ziziphi Spinosae, Polyporus, India skullcap, Herba Artemisiae Scopariae, Herba Sedi, Rhizoma Coptidis according to formula, said components mixture is ground into coarse powder, crosses 30 mesh sieves, cross drainage by 10 times amount and be made as solvent, use countercurrent extraction method, after being filtered by extracting solution machine by centrifugation, to be concentrated into density be 1.25 in heating, after add 95% ethanol dilution to 60%, wine sinks method, static 24 hours, extract supernatant recovery ethanol and obtain clear paste, dry for standby;
S2, weighing Radix Ginseng, Fructus Schisandrae Chinensis according to formula, co-grinding crosses 100 mesh sieves, obtains fine powder standby;
S3, weigh Formica fusca, Zaocys, Scolopendra, Radix Angelicae Sinensis according to formula, size-reduced one-tenth coarse powder, rear through leaching clear liquid recovery ethanol, obtain fluid extract with 60% ethanol countercurrent extraction, drying is standby;
S4, the prepared product of above-mentioned S1, S2 and S3 is pulverized and mixed, dispensing, stirring, detection, subpackage, obtain pharmaceutical product.
Said medicine is hard capsule or granule or tablet or pill or powder.
Clinical statistics: this medicine treats viral hepatitis as proved recipe Clinical practice, there are 1013 examples of statistical significance, wherein acute jaundice type viral hepatitis 83 example, chronic persistent hepatitis B 30 example, chronic active hepatitis B 440 example, posthepatitic cirrhosis 230 example, alcohol cirrhosis 30 example, Chronic Severe Viral Hepatitis 130 example, toxic hepatitis 70 example, total effective rate 93.5%, obvious effective rate 82.8%, without toxicity.
Model case illustrates: Lee so-and-so, man, 47 years old, suffer from Chronic Severe Viral Hepatitis, liver cirrhosis, ascites, splenomegaly, become thin, suffer from diarrhoea, weak, dizzy, insomnia, lack of appetite. After taking this medicine one month, above-mentioned symptom disappears, and serve on three months immune indexes and recovers normal, and Liver and kidney function is normal, has no adverse reaction.
The invention is not limited in above-mentioned embodiment, if to the various modification of the present invention or change without departing from the spirit and scope of the present invention, if these change within claim and the equivalent technologies scope belonging to the present invention with modification, then the present invention is also intended to comprise these change and modification.

Claims (3)

1. the medicine treating second, the third viral hepatitis, it is characterised in that include the component of following mass percent:
Radix Ginseng 5%, the Rhizoma Atractylodis Macrocephalae 7%, Formica fusca 7%, Zaocys 7%, Scolopendra 6%, Serissa foetida 7%, Radix Angelicae Sinensis 10%, Fructus Schisandrae Chinensis 5%, Semen Ziziphi Spinosae 10%, Polyporus 10%, India skullcap 7%, Herba Artemisiae Scopariae 7%, Herba Sedi 5%, Rhizoma Coptidis 7%.
2. a kind of medicine treating second, the third viral hepatitis according to claim 1, it is characterised in that: described medicine is hard capsule or granule or tablet or pill or powder.
3. a kind of process for preparing medicine treating second, the third viral hepatitis as claimed in claim 1, it is characterised in that include following steps:
S1, weigh the Rhizoma Atractylodis Macrocephalae, Serissa foetida, Semen Ziziphi Spinosae, Polyporus, India skullcap, Herba Artemisiae Scopariae, Herba Sedi, Rhizoma Coptidis according to formula, said components mixture is ground into coarse powder, crosses 30 mesh sieves, cross drainage by 10 times amount and be made as solvent, use countercurrent extraction method, after being filtered by extracting solution machine by centrifugation, to be concentrated into density be 1.25 in heating, after add 95% ethanol dilution to 60%, wine sinks method, static 24 hours, extract supernatant recovery ethanol and obtain clear paste, dry for standby;
S2, weighing Radix Ginseng, Fructus Schisandrae Chinensis according to formula, co-grinding crosses 100 mesh sieves, obtains fine powder standby;
S3, weigh Formica fusca, Zaocys, Scolopendra, Radix Angelicae Sinensis according to formula, size-reduced one-tenth coarse powder, rear through leaching clear liquid recovery ethanol, obtain fluid extract with 60% ethanol countercurrent extraction, drying is standby;
S4, the prepared product of above-mentioned S1, S2 and S3 is pulverized and mixed, dispensing, stirring, detection, subpackage, obtain pharmaceutical product.
CN201610094550.3A 2016-02-19 2016-02-19 Medicine for treating viral hepatitis B and viral hepatitis C and preparation method of medicine Pending CN105641168A (en)

Priority Applications (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106038667A (en) * 2016-07-29 2016-10-26 桂林淮安天然保健品开发有限公司 Pharmaceutical composition for treating hepatitis C

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101524435A (en) * 2009-04-23 2009-09-09 莫以贤 Pure natural drug for treating viral hepatitis
CN104474023A (en) * 2014-11-29 2015-04-01 张莘蔓 Traditional Chinese medicine composition for treating viral hepatitis
CN104606281A (en) * 2015-02-01 2015-05-13 徐鸿刚 Traditional Chinese medicine for treating viral hepatitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101524435A (en) * 2009-04-23 2009-09-09 莫以贤 Pure natural drug for treating viral hepatitis
CN104474023A (en) * 2014-11-29 2015-04-01 张莘蔓 Traditional Chinese medicine composition for treating viral hepatitis
CN104606281A (en) * 2015-02-01 2015-05-13 徐鸿刚 Traditional Chinese medicine for treating viral hepatitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106038667A (en) * 2016-07-29 2016-10-26 桂林淮安天然保健品开发有限公司 Pharmaceutical composition for treating hepatitis C

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