CN101366858B - Preparation method of medicament for clearing heat, discharging fire, dispelling wind and relieving pain - Google Patents
Preparation method of medicament for clearing heat, discharging fire, dispelling wind and relieving pain Download PDFInfo
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Abstract
The invention provides a method for preparing a medicine used for clearing heat and purging fire, dispelling wind and relieving pain. The medicine consists of calculus bovis factitious, mint, chryanthemum flower, spica schizonepetae, dahurian angelica root, hemlock parsley, cape jasmine fruit, coptis root, phellodendron, baikal skullcap root, rhubarb, fosythia fruit, red paeonia root, angelica, rehmanniae, platycodon root, liquorice, gypsum and borneol. The method for preparing the medicine comprises the following steps: extracting volatile oil from the mint, the spica schizonepetae, the hemlock parsley, the angelica and the chryanthemum flower; extracting dregs of the drugs, the cape jasmine fruit, the coptis root, the phellodendron, the red paeonia root, the rehmanniae, the liquorice and the gypsum water to produce clear paste; ramming the dahurian angelica root, the fosythia fruit, the baikal skullcap root and the platycodon root into coarse powder, and using ethanol as menstruum to extract the coarse powder to produce clear paste; micronizing the rhubarb into the mixed powder material of fine powder, micro-powder and nano-powder; and mixing the clear paste extracted by water and the clear paste extracted by ethanol, adding the calculus bovis factitious and the borneol fine powder with the mixed paste, and spraying the volatile oil into the mixed paste to produce pill medicine or capsule medicine. The method can improve the bioavailability, increase healing efficacy and improve working environment.
Description
Technical field
The present invention relates to a kind of its preparation method that is used for clearing away heat-fire, diffusing wind analgesic drug product.
Background technology
The 'Niuhuang Shangqing ' of selling on the market has pill, capsule, tablet, and wherein pill is the 6g/ ball, every day 2 times; Capsule is the 0.3g/ grain, every day 2 times, each 3; Tablet is the 0.3g/ sheet, every day 2 times, each 4.These kinds all have defective in various degree at aspects such as taking dose, outward appearance, quality, mouthfeel, disintegrate, curative effects.So the 'Niuhuang Shangqing ' patent of new dosage form and preparation method produces in succession.Number of patent application is that cow-bezoar microbolus of 200510087331.4 and preparation method thereof is by adopting novel adjuvants such as microcrystalline Cellulose, polyvinylpolypyrrolidone; with extruding---spheronization is made into micropill; can reach than traditional general method for making, mould the cow-bezoar bolus for clearing away heat of the upper part of the body of the better face shaping of method for making; not only smooth in appearance is neat, mouthfeel good, and faster than water pill disintegrate.
Another relevant patent is that application number is nano medicine ' Niuhuang Shangqing ' of 01100875.x and preparation method thereof; this patent is to adopt microwave extracting, concentrating under reduced pressure, supersonic jet, the spray drying technology various medical materials in will write out a prescription to become nanoscale powder footpath, thereby reaches the purpose of raising drug bioavailability and therapeutic effect.
The present invention is different from above-mentioned two and applies for a patent part and be: the flavor of 19 during the present invention will write out a prescription Chinese crude drug adopts four kinds of processing methods, and promptly artificial Calculus Bovis, Borneolum Syntheticum pulverize separately become fine powder; The Radix Et Rhizoma Rhei superfine powder is broken into fine powder, micropowder, nano powder; Herba Menthae, Herba Schizonepetae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Chrysanthemi extract volatile oil with the way of distillation; The Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scutellariae, Radix Platycodonis ethanol extraction effective ingredient; Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Glycyrrhizae, Gypsum Fibrosum water extraction extractum; The intermediate of four kinds of methods is made tablets/capsules/granule.
The present invention compares with 200510087331.4 cow-bezoar microbolus and preparation method, its medical material processing method difference.Radix Et Rhizoma Rhei of the present invention adopts micronizing mainly to be owing to contain heat-labile anthraquinone class chemical constituent in the Radix Et Rhizoma Rhei, can increase its dissolution rate after adopting micronizing, improve the Radix Et Rhizoma Rhei utilization rate, and strengthening discharge function, aspect various bacteria inhibitory action, antiinflammatory action obvious enhancing arranged, thereby treatment acute pharyngitis, acute tonsillitis, gingivitis are obtained better effect.
The present invention adopts its effective active composition of ethanol extraction to compare to the way of distillation extraction Radix Angelicae Dahuricae, Fructus Forsythiae the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scutellariae, Radix Platycodonis and water extraction extracts Radix Scutellariae, Radix Platycodonis has one's own knack.The Radix Angelicae Dahuricae is the dry root of the samphire Radix Angelicae Dahuricae, the anti-Radix Angelicae Dahuricae; imperatorin is its main effectively one of active component; imperatorin is the Coumarins composition; at antipyretic-antalgic, antiinflammatory, relieving asthma, effective in cure (Zheng Huzhan, She Jing etc. aspect the blood pressure lowering, antibiotic, spasmolytic; " Chinese medicine modern study and application ", 1997.1511).Studies show that the ethanol extraction total coumarins with 50% or 70% and imperatorin recovery rate are quite and relative higher.
Fructus Forsythiae is the dry fruit of Oleaceae plant Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl, has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds effect, mainly contains two constituents, and a class is a phenylethanol, is the antipathogenic composition in the Fructus Forsythiae, based on the Fructus Forsythiae ester glycoside class; Another kind of is lignin, has the heat clearing away effect, and phillyrin and forsythin are arranged.The present invention adopts alcohol extraction Fructus Forsythiae method, Fructus Forsythiae dry extract (total solid) is better than water and carries, and contained phillyrin, Fructus Forsythiae ester glycoside constituents are higher, thereby can reach the reduction amount of impurities, improve infection, analgesic therapeutic effect.
Radix Scutellariae is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi, have heat clearing and damp drying, let out fiery antidotal effect, main component is a flavone compound, its extracting method has water extraction and alcohol extracting method, but water extraction is limited to glycoside more, and water solublity invalid components such as starch, tannin, resin also are suggested, and adopt pure extracting method can improve the total flavones recovery rate, make flavones ingredient effect aspect antiviral, antibiotic, antioxidant radical stronger, thereby reach the purpose that improves curative effect.Radix Platycodonis is the dry root of campanulaceae plant Platycodon grandiflorm (Jacq) A.DC., has the disappear effect of infections of preventing phlegm from forming and stopping coughing, relieving sore throat to recover voice, the smooth lung qi of a surname, evacuation of pus, mainly contain triterpene saponin, flavone compound, phenolic compound, most of active substance in these effective actives be can extract with alcohol, thereby immunomodulating, antiinflammatory brought into play better, eliminate the phlegm, end the therapeutical effect of pharyngalgia.
Summary of the invention
The purpose of this invention is to provide a kind of preparation method that is used for clearing away heat-fire, diffusing wind analgesic drug product.
The present invention is achieved like this, and it is to be prepared from by following bulk drugs:
Artificial Calculus Bovis 1-5 Herba Menthaes 35-55 Flos Chrysanthemis 45-70 Herba Schizonepetaes 15-35
The Radix Angelicae Dahuricae 15-35 Rhizoma Chuanxiongs 15-35 Radix Scutellariaes 60-88 Radix Et Rhizoma Rhei 90-140
Fructus Gardeniae 60-88 Rhizoma Coptidis 15-35 Cortex Phellodendris 9-20 Fructus Forsythiaes 60-88
Radix Paeoniae Rubra 15-35 Radix Angelicae Sinensis 60-88 Radix Rehmanniae 80-110 Radix Platycodoniss 15-35
Radix Glycyrrhizae 9-20 Gypsum Fibrosum 90-140 Borneolum Syntheticums 9-20
Get Herba Menthae, Herba Schizonepetae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Chrysanthemi, the aqueous solution after distillating extracting oil, distillation device is in addition collected standby; Get above-mentioned medicinal residues and Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Glycyrrhizae, Gypsum Fibrosum decocts with water 2-3 times, each 1-3 hours, collecting decoction, filter, aqueous solution after filtrate and the above-mentioned distillation merges, and the survey relative density is 1.32-1.36 clear paste when being concentrated into 55 ℃, and is standby; Get the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scutellariae, Radix Platycodonis and break into coarse powder, the ethanol with 50%-85% is that solvent extracts, and reclaims ethanol, surveys relative density when being evaporated to 55 ℃ and be 1.20-1.36 clear paste, and is standby; Borneolum Syntheticum, artificial Calculus Bovis's pulverize separately become fine powder, cross 120 mesh sieves, and be standby; Get Radix Et Rhizoma Rhei, superfine powder is broken into the micropowder of 0.1 μ m-10 μ m particle diameter and less than the nano powder mixed powder of 0.1 μ m, and by be no less than 95% the powder rate be left and taken standby; With above-mentioned water carry, the clear paste of alcohol extraction mixes, and Radix Et Rhizoma Rhei powder and adjuvant joined mix in the clear paste, granulates, and is dry below 80 ℃, adds artificial Calculus Bovis, Borneolum Syntheticum fine powder mixing, sprays into the above-mentioned volatile oil with dissolve with ethanol, sieves, mixing is made tablet.
With above-mentioned water carry, the clear paste of alcohol extraction mixes, and the Radix Et Rhizoma Rhei powder joined mix in the clear paste, and is dry below 80 ℃, is ground into fine powder; add artificial Calculus Bovis, Borneolum Syntheticum fine powder, mixing sprays into the above-mentioned volatile oil with dissolve with ethanol, sieves; mixing, the Capsules of packing into gets capsule.
Extracting method of the present invention also as: get Herba Menthae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Chrysanthemi, Fructus Forsythiae, extract volatile oil respectively, distillate in addition device is preserved, and is standby; Medicinal residues and Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Platycodonis, Radix Glycyrrhizae, Gypsum Fibrosum water extraction 2-3 times, each 1-3 hours, merge extractive liquid, filtered, and the survey relative density was 1.32-1.36 clear paste when filtrate was concentrated into 55 ℃, and is standby.
Described Radix Et Rhizoma Rhei mixed powder is to be the fine powder of 10～150 μ m based on particle diameter; Artificial Calculus Bovis, Borneolum Syntheticum were the common fine powder of 120 mesh sieves.
Described Radix Et Rhizoma Rhei mixed powder is to be the micropowder of 0.1～10 μ m based on particle diameter.
Described Radix Et Rhizoma Rhei mixed powder is based on the nano powder of particle diameter less than 0.1 μ m.
Described Radix Et Rhizoma Rhei mixed powder is made up of two kinds of powders in fine powder, micropowder, three kinds of powders of nano powder at least.
Advantage of the present invention is: innovate aspect two and improve, the one, Radix Et Rhizoma Rhei is adopted superfine communication technique, can improve the utilization rate of medical material, also can increase the dissolution rate of Radix Et Rhizoma Rhei, because Radix Et Rhizoma Rhei is without heating extraction, anthraquinone class chemical constituent is not destroyed, thereby the effect of anxious slow pharyngitis, acute tonsillitis, gingivitis is treated in performance better, thereby reaches the effect of quick antibacterial antiinflammatory.Another improvements are will change the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scutellariae, Radix Platycodonis into alcohol extraction by the way of distillation and water extraction respectively originally, the abundant stripping of alcohol dissolubility effective ingredient, wherein contained total coumarins, imperatorin, Fructus Forsythiae ester glycoside, phillyrin, forsythin, Radix Scutellariae total flavones, triterpene saponin, phenolic compound active component content height, and the water-solubility impurity composition is not dissolved or stripping is less, can bring into play better effect aspect minimizing taking dose, raising curative effect, the minimizing untoward reaction.
The specific embodiment
Embodiment 1
Get Herba Menthae, Herba Schizonepetae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Chrysanthemi, distillating extracting oil, the aqueous solution after the distillation device are in addition collected standby; Get above-mentioned medicinal residues and Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Glycyrrhizae, Gypsum Fibrosum decocts with water 2 times, each 2 hours, collecting decoction filtered, the aqueous solution after filtrate and the above-mentioned distillation merges, the survey relative density is 1.35 thick paste when being concentrated into 55 ℃, and is standby; Get the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scutellariae, Radix Platycodonis and break into coarse powder, the ethanol with 70% is solvent, extracts with percolation, reclaims ethanol, surveys relative density when being evaporated to 55 ℃ and be 1.30 clear paste, and is standby; Borneolum Syntheticum, artificial Calculus Bovis's pulverize separately become fine powder, cross 120 mesh sieves, and be standby; Get Radix Et Rhizoma Rhei, superfine powder is broken into the micropowder of 0.1 μ m-10 μ m particle diameter and less than the nano powder mixed powder of 0.1 μ m, and by be no less than 95% the powder rate be left and taken standby; The thick paste that water is carried and the clear paste of alcohol extraction mix, and Radix Et Rhizoma Rhei powder and microcrystalline Cellulose are joined mix in the clear paste, granulate, and be dry below 80 ℃, adds artificial Calculus Bovis, Borneolum Syntheticum fine powder, sprays into the volatile oil with dissolve with ethanol, sieves, and mixing is made tablet.
Test 1 Calculus Bovis supernatant anti-infectious function in vivo
Get 80 of Kunming mouses, 18～22g, healthy wistar rat, body weight 180～220g, male and female half and half.Mice is divided into 5 groups at random, the old Calculus Bovis supernatant of matched group (0.3g/kg), the present invention's (newly) 'Niuhuang Shangqing ' group (0.3g/kg), the present invention's (newly) Calculus Bovis supernatant group (greatly) is 3 dosage groups (0.6g/kg), berberine hydrochloride group (0.3g/kg).The equal intraperitoneal injection of each administration group, the administration volume is 0.2ml/10g, once a day, and successive administration three days, matched group gives the normal saline of equivalent.The end administration after 1 hour, press preliminary experiment dosage lumbar injection bacillus pyocyaneus (0.2ml/10g), 72 hours animal dead numbers after the record bacterial injection calculate mortality rate, escherichia coli (0.2ml/10g), staphylococcus aureus (0.1ml/10g) experimentation are identical therewith, the results are shown in Table 1.
Table 1 Calculus Bovis supernatant antibacterium (bacillus pyocyaneus, escherichia coli, staphylococcus aureus) infection experiment
Annotate: * P＜0.05, * * P＜0.01, matched group is compared.(1) charrin's disease; (2) coli-infection; (3) infection of staphylococcus aureus.
Experimental result shows that the product of preparation method of the present invention is better than original old preparation and positive controls aspect infection, with above-mentioned 2 groups and blank group significant difference and significant differences is arranged relatively.
Embodiment 2
Get Herba Menthae, Herba Schizonepetae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Chrysanthemi, extract respectively after volatile oil, the distillation aqueous solution in addition device collect standby; Get above-mentioned medicinal residues and Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Glycyrrhizae, Gypsum Fibrosum decocts with water 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filters, and the aqueous solution after filtrate and the above-mentioned distillation merges, the survey relative density is 1.32 clear paste when being concentrated into 55 ℃, and is standby; Get the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scutellariae, Radix Platycodonis and break into coarse powder, the ethanol with 65% is solvent, and reflux, extract, reclaims ethanol, surveys relative density when being evaporated to 55 ℃ and be 1.32 clear paste, and is standby; Get Borneolum Syntheticum, artificial Calculus Bovis's pulverize separately becomes fine powder, crosses 120 mesh sieves, and is standby; Get that the Radix Et Rhizoma Rhei superfine powder is broken into the micropowder of 0.1 μ m-10 μ m particle diameter and less than the nano powder mixed powder of 0.1 μ m, and by be no less than 95% the powder rate be left and taken standby; The clear paste that water is carried and the clear paste of alcohol extraction mix, and the Radix Et Rhizoma Rhei powder is joined in the above-mentioned mixing clear paste, and be dry below 80 ℃, is ground into fine powder; add artificial Calculus Bovis, Borneolum Syntheticum fine powder, mixing sprays into the volatile oil with dissolve with ethanol, sieves; mixing, the Capsules of packing into gets capsule.
Test the refrigeration function of 2 the old and new's Calculus Bovis supernatants to rabbit endotoxin fever model
Laboratory adapt to be raised after 3 days, selected qualified rabbit (in a day at interval 1 hour double record the variation of anus temperature and be no more than 0.3 ℃ of person) and was divided into 5 groups at random; Matched group; Old Calculus Bovis supernatant (0.50g/kg), new Calculus Bovis supernatant (0.50g/kg), new 3 groups of Calculus Bovis supernatant (1.0g/kg); Positive control QINGKAILING group (12.5ml/kg).Each administration group experiment is worked as average daily intraperitoneal injection once, and the administration volume is 0.2ml/10g, and matched group gives the equivalent normal saline.
10h begins fasting before the experiment, measures anus temperature twice behind the emptying rectum, each one hour at interval, averages as basal body temperature.Each administration group is distinguished intraperitoneal injection of drugs then, and the matched group lumbar injection is with the volume normal saline.After the last administration 1 hour, left side auricular vein injection escherichia coli endotoxin solution, injected dose is 10EU/kg, measure anus temperature respectively to 1,2,3,4,6 hour rabbit behind the endotoxin, calculate the lift-off value of each measuring point rabbit body temperature, and compare, the results are shown in Table 2.
Table 2 the old and new Calculus Bovis supernatant is to the refrigeration function of fever in rabbits due to the endotoxin
Annotate: compare * P＜0.05, * * P＜0.01 with matched group.
The result shows, the old and new's 'Niuhuang Shangqing ' group and Qingkailing injection administration group can suppress obviously all that rabbit body temperature raises due to the endotoxin, and the invention group is better than old 'Niuhuang Shangqing ', compared significant difference with matched group.
Test 3 Radix Et Rhizoma Rhei and pulverize recovery rate
The result shows that micronizing gets the powder rate and pulverizes height than tradition, medical material utilization rate height, and dust is little, and environmental conservation is good, has social economy's double meaning.
Test 4 different process and handle the influence of Radix Et Rhizoma Rhei defecation
Get 48 of mices, be divided into 4 groups at random, be i.e. blank group, diphenoxylate constipation model group, new Calculus Bovis supernatant group, old Calculus Bovis supernatant group.Behind the mice fasting 12h, the blank group gives the isometric(al) distilled water, and all the other each treated animals are irritated stomach (ig) respectively and given compound diphenoxylate (10mg/kg), duplicates mice constipation model, and the administration volume is 0.2ml/10g.30min after the modeling, old preparation group, novel formulation group give relative medicine by the listed dosage ig of table 4 respectively, and blank group and constipation model group ig give isometric(al) prepared Chinese ink, irritate the long-pending 0.2ml/10g that is of body of stomach.Behind the gastric infusion the single cage of mice is raised, the normal diet water inlet, every the first grain of mice defecation time, defecation weight in defecation grain number and the 6h in the 6h observed in record.
Experimental data meets normal distribution, the neat person of variance and carries out statistical procedures with variance analysis or t check, heterogeneity of variance person t check, do not meet normal distribution with rank test (following all with), experimental result sees Table 4.
Table 4 the old and new 'Niuhuang Shangqing ' to diphenoxylate cause the mice with constipation bowel movement function influence (x ± s, n=12)
Annotate: model group compares △ △ P＜0.01 with blank group; Administration group and model group compare, * * P＜0.01, * P＜0.05
The result shows, can cause mice constipation model for mice ig compound diphenoxylate, and constipation model group and blank group are relatively, head is the time significant prolongation just, the interior defecation weight of defecation grain number and 6h significantly reduces in the 6h, and difference has highly significant meaning (P＜0.01), and the modeling success is described.Novel formulation group and constipation model group compare, and first grain defecation time shortens, and difference has highly significant meaning (P＜0.01); Defecation grain digital display work increases in the 6h, and difference has significance meaning (P＜0.05), and defecation weight significantly increases in the 6h, and difference has highly significant meaning (P＜0.01), illustrates that novel formulation can promote and increase the defecation of mice.
Old preparation group and model group relatively, head is time difference nonsignificance (P＜0.05) just, it is not obvious to show that old preparation can shorten the effect of defecation time, may to bring into play the effect of curative effect comparatively slowly relevant with medicine; The animal of old preparation group, defecation grain number increases to some extent in the 6h, but compares with model group, learns by statistics and handles, and difference does not have significance meaning (P＜0.05); Mainly be since the animal wastes grain to count difference in size bigger, still measured defecation weight in each treated animal 6h again.
Old preparation can make defecation weight increase in the mice 6h, compares with model group, learns by statistics and handles, and difference has significance meaning (P＜0.05), a little less than relatively acting on novel formulation, significance meaning (P＜0.05) is arranged also.
Claims (3)
- One kind be used for clearing away heat-fire, the preparation method of the wind analgesic drug product that looses, its crude drug is a weight portion:
It is characterized in that:A, get Herba Menthae, Herba Schizonepetae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Chrysanthemi, the aqueous solution after distillating extracting oil, distillation device is in addition collected, and volatile oil is standby;B, the medicinal residues of getting the A step and Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Glycyrrhizae, Gypsum Fibrosum decoct with water 2-3 time, and each 1-3 hour, collecting decoction, filter, aqueous solution after filtrate and the above-mentioned distillation merges, and surveys relative density when being concentrated into 55 ℃ and is the clear paste of 1.32-1.36, and is standby;C, getting the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scutellariae, Radix Platycodonis and break into coarse powder, is that solvent extracts with the ethanol of 50%-85%, reclaims ethanol, surveys relative density when being evaporated to 55 ℃ and is the clear paste of 1.20-1.36, standby;D, get Borneolum Syntheticum, artificial Calculus Bovis's pulverize separately becomes fine powder, crosses 120 mesh sieves, and is standby;E, get Radix Et Rhizoma Rhei, superfine powder is broken into the micropowder of 0.1 μ m-10 μ m particle diameter and less than the nano powder mixed powder of 0.1 μ m, and by be no less than 95% the powder rate be left and taken standby;F, the clear paste of step B and step C is mixed, the step e powder is joined in the mixing clear paste of B, C, dry below 80 ℃; be ground into fine powder, add artificial Calculus Bovis, Borneolum Syntheticum fine powder, spray into volatile oil with the steps A of dissolve with ethanol; sieve, mixing is made tablet or the Capsules of packing into. - 2. a kind of preparation method that is used for clearing away heat-fire, diffusing wind analgesic drug product as claimed in claim 1, it is characterized in that: described Radix Et Rhizoma Rhei mixed powder is to be the micropowder of 0.1～10 μ m based on particle diameter.
- 3. a kind of preparation method that is used for clearing away heat-fire, diffusing wind analgesic drug product as claimed in claim 1, it is characterized in that: described Radix Et Rhizoma Rhei mixed powder is based on the nano powder of particle diameter less than 0.1 μ m.
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| CN101690757B (en) * | 2009-09-15 | 2011-05-11 | 江西天施康中药股份有限公司 | Method for preparing bezoar supernatant preparations |
| CN102614292A (en) * | 2012-02-26 | 2012-08-01 | 刘天岐 | Radix angelicae antiphlogosis powder |
| CN102688336A (en) * | 2012-03-16 | 2012-09-26 | 江西天施康中药股份有限公司 | Bezoar supernatant composite and preparation method thereof |
| CN102727651B (en) * | 2012-07-10 | 2013-12-11 | 江西天施康中药股份有限公司 | Preparation method and quality detection method of bezoar supernatant capsule |
| CN104398848A (en) * | 2014-12-10 | 2015-03-11 | 李洋 | Traditional Chinese medicine composition for treating acute pharyngitis and preparation method and application |
| CN105381317A (en) * | 2015-12-25 | 2016-03-09 | 张永红 | Medicine for treating headache and preparation method thereof |
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