CN100998780B

CN100998780B - Traditional Chinese medicine dripping pills for relieving exterior syndrome, removing dampness regulating the stomach and its preparing method

Info

Publication number: CN100998780B
Application number: CN2006100111758A
Authority: CN
Inventors: 李祖泽; 施少斌; 郑荣波; 沈军; 黄晓丹
Original assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Current assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Priority date: 2006-01-12
Filing date: 2006-01-12
Publication date: 2011-04-20
Anticipated expiration: 2026-01-12
Also published as: CN100998780A

Abstract

A Chinese medicine in the form of dripping pill for relieving exterior syndrome, dispelling dampness and regulating stomach is prepared from 16 Chinese-medicinal materials including uncaria stem with hooks, magnolia bark, trichosanthes root, tuckahoe, etc. Its preparing process is also disclosed.

Description

A kind of have induce sweat, dry and in Chinese medicine dripping pills and preparation method thereof

Technical field

The present invention relates to field of medicaments, particularly relate to a kind of have induce sweat, dry and in Chinese medicine dripping pills and preparation method thereof.

Background technology

Stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset, dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache are clinical common symptoms, these symptoms can be caused by multiple reason.In Song dynasty " formulary of peaceful benevolent dispensary " these symptoms are put down in writing to some extent, and the prescription of ageratum side as treatment is provided.Ageratum side is described as " heat-damp in summer panacea " by ancient Chinese medicine doctor.This side have induce sweat, damp eliminating and in effect, be usually used in treating the treatment of affection of exogenous wind-cold, internal injury humidity hysteresis, stomachache vomiting and diarrhoea clinically, mainly be with stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache etc. are clinical manifestation, also are widely used at present the treatments such as common cold of gastrointestinal type, acute chronic enteritis of modern medicine.Health pill is a kind of traditional Chinese medicine, is the novel formulation that develops on the basis of the former technology of the positive invigorating oral liquid of traditional Radix agastaches, and China's " pharmacopeia " includes it wherein already.Health pill have induce sweat, damp eliminating and in function; Be mainly used in stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, the treatment of fever and headache.The Health pill of putting down in writing in the pharmacopeia adopts the method for making of " each pulverizing medicinal materials; general ball; coating ", its productive labor intensity is big, with low content of technology, prescription Chinese medicine effective ingredient is not extracted, thereby cause Health pill to exist the medicine active ingredient in gastrointestinal dissolution rate and absorbance reduction, soak time prolongs, and onset is slow, and because Health pill bad smell when taking can make the patient produce resentment.

Chinese invention patent number 200410027334.4 titles are made and are protected the Ji sheet, decoct with water owing to Ramulus Uncariae Cum Uncis in its technology that adopts, be not easy to extract fat-soluble effective ingredient in the Ramulus Uncariae Cum Uncis, and multiple medical material as: Six-element medicines such as the Radix Aucklandiae, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Pogostemonis adopt CO respectively ₂The process more complicated of extraction, the cycle of finishing production is long, and cost is higher.

Summary of the invention

The purpose of this invention is to provide a kind of have induce sweat, dry and in Chinese medicine dripping pills.

Another object of the present invention provide a kind of have induce sweat, dry and in active constituents of medicine.

Another object of the present invention provide a kind of have induce sweat, dry and in the preparation method of Chinese medicine dripping pills.

Medicine of the present invention is to be made by Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis.

The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through the inventor, and each component raw material all has curative effect preferably at the following weight parts ratio range: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss.

Preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss.

Best each component raw material medicine of pharmaceutical composition of the present invention has curative effect preferably in the following weight parts proportioning: 34.10 parts of Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss.

The preparation of the active component of the present composition and preparation can adopt following method: one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, but this can not limit protection scope of the present invention.

The proportioning that following medicine activity component extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine weight proportion is a dosage range provided by the present invention.

A. get 15.50～55.80 parts of crude drug Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil is standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder and volatilization mix homogeneously, preparation cost invention medicine activity component.

Preferably, the active component preparation method of Chinese medicine composition of the present invention, its feature comprises the steps:

A. get 27.17～41.20 parts of crude drug Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and are standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1～4 time, each 0.5～5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1～4 time, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder and volatile oil mix homogeneously, preparation cost invention medicine activity component.

Further preferred, the preparation method of Chinese medicine composition active component of the present invention, its feature comprises the steps:

A. it is standby to get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil is standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1～3 time, each 0.5～3 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1～3 time, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

The preparation method of the invention described above Chinese medicine composition active component, wherein among the step b volatile oil with the dextrin embedding of 2～9 times of amounts; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 30～99% ethanol extractions.

The preparation method of preferred Chinese medicine composition active component of the present invention, wherein the volatile oil among the step b is with the dextrin embedding of 3～8 times of amounts; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 50～95% ethanol extractions.

The further preparation method of preferred Chinese medicine composition active component of the present invention, wherein the volatile oil among the step b is with the dextrin embedding of 3～8 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3～8 times of amounts, each 1～2 hour; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, each 0.5～4 hour.

The preparation method of further preferred Chinese medicine composition active component of the present invention, wherein the volatile oil among the step b is with the dextrin embedding of 3.5～6 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, each 1～2 hour; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 3.5～6 times of amounts, 55～90% ethanol extractions 1～2 time, each 1～3 hour.

The preparation method of best Chinese medicine composition active component of the present invention, wherein the volatile oil among the step b is with the dextrin embedding of 5.5 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, 2 hours for the first time, 1 hour for the second time; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 4 times of amounts, 70% ethanol extraction 2 times, 2 hours for the first time, 1 hour for the second time.

The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, makes any preparation on the pharmaceutics; Be prepared into any common formulations as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as tablet, sugar coated tablet, film coated tablet, enteric coated tablet, powder, capsule, soft capsule, pill, electuary, oral liquid, granule, drop pill, micropill, intramuscular injection agent, instillation, unguentum, ointment, plaster etc.; The best is made tablet, drop pill, oral liquid, granule, capsule, soft capsule.

The invention provides a kind of Traditional Chinese Medicine Dropping Pill that contains above-mentioned active component.

Chinese medicine dripping pills of the present invention is to adopt the active component of above-mentioned preparation and drop pill adjuvant commonly used to be prepared from according to the conventional preparation method of drop pill; Wherein said active component is that dry extract and volatile oil or cyclodextrin inclusion compound mix with drop pill adjuvant commonly used.

Preferred Chinese medicine dripping pills of the present invention, be to adopt in the mixture of the dry extract of above-mentioned preparation and volatile oil or cyclodextrin inclusion compound, add the one or any combination in polyethylene glycol 6000, Macrogol 4000, the polyethylene glycol 1500, heating dissolves, adopting a speed is 15～90/min, splash in the condensed fluid, promptly get drop pill.

Further preferred Chinese medicine dripping pills of the present invention, be to adopt in the mixture of the dry extract of above-mentioned preparation and volatile oil or cyclodextrin inclusion compound, add polyethylene glycol 6000, the one or any combination of Macrogol 4000, heating dissolves, adopting a speed is 20～80/min, splash in the condensed fluid, promptly get drop pill.

Further preferred Chinese medicine dripping pills of the present invention, be to adopt in the mixture of the dry extract of above-mentioned preparation and volatile oil or cyclodextrin inclusion compound, the polyethylene glycol 6000 that adds dry extract fine powder and volatile oil or 1～30 times of amount of dextrin embedding thing: Macrogol 4000=1～5: 1～4 mixture, heating dissolves, adopting a speed is 25～75/min, splash into liquid Paraffin, or methyl-silicone oil or methyl-silicone oil: liquid Paraffin=1～4: in 1～3 the condensed fluid, promptly get drop pill.

Best Chinese medicine dripping pills of the present invention, be to adopt in the mixture of the dry extract of above-mentioned preparation and volatile oil or cyclodextrin inclusion compound, the polyethylene glycol 6000 that adds dry extract fine powder and volatile oil or 20 times of amounts of dextrin embedding thing: the mixture of Macrogol 4000=3: 2, heating dissolves, adopting a speed is 40/min, splash into liquid Paraffin, or methyl-silicone oil: liquid Paraffin is in 3: 1 the condensed fluid, promptly to get drop pill.

Dextrin among the present invention is a betacyclodextrin.

More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.

The specific embodiment

In order to understand the present invention better, logical below test example is further set forth the beneficial effect of medicine of the present invention.These test examples comprise the pharmacodynamics test of medicine of the present invention.Below used medicine prepares according to embodiment 15 methods in the test.

One, medicine of the present invention is to the mice gastric emptying, the influence of intestinal propulsion

Medicine of the present invention adopts the production technology of pressing embodiment 15 to produce and obtains.Get said medicine, grind, add water and become pasty state.

Control drug: Health pill, commercially available, adopt identical pastel.

1. adopt the semi-solid gastric emptying experimental technique of mice, observe medicine of the present invention normal mouse and dopamine hydrochloride are caused the influence of mice delayed gastric emptying, the result shows: (1) medicine of the present invention, Health pill are not obvious to the normal mouse gastric emptying.(2) the simple dopamine hydrochloride group of nutrition paste residual quantity significantly reduces (P＜0.01 or P＜0.05) in two dosage of medicine of the present invention (1.85g/kg, 3.70g/kg), Health pill (1.85g/kg), fourth woods (5mg/kg) stomach, and medicine of the present invention, the Health pill of prompting doses all have antagonism to the mice delayed gastric emptying that dopamine hydrochloride causes.

2. adopt mouse small intestine charcoal end propulsion trial, observe medicine of the present invention and contrast medicine Health pill, and at neostigmine, epinephrine, atropine cause that mouse small intestine advances antagonism hyperfunction or that suppress the propulsive influence of small intestine movement of mice.The result shows that (1) medicine low dose of the present invention has the propulsive effect of the small intestine movement of mice of quickening, and two dosage effects of middle and high dosage and Health pill are not obvious.(2) small intestinal that causes at neostigmine of two dosage of middle and high dosage of medicine of the present invention and Health pill is hyperfunction an inhibitory action.(3) medicine high dose of the present invention causes that to atropine intestinal propulsion suppresses antagonism is arranged, and two dosage effects of little, middle dosage and Health pill are not obvious.(4) three dosage of medicine of the present invention cause that at epinephrine intestinal propulsion suppresses antagonism is arranged, and the Health pill effect is not obvious.

Above result shows, medicine doses of the present invention causes that at neostigmine mouse small intestine advances the hyperfunction inhibitory action that has, and the mouse small intestine that epinephrine or atropine are caused advances and suppresses also to have certain antagonism.Results suggest, medicine of the present invention has regulating action to mice gastric emptying, intestinal motility disorder.One of symptom that medicine of the present invention cures mainly is a gastrointestinal upset, dyspepsia, and both all can show the gastrointestinal motility dysfunction, this effect should be that its treatment gastrointestinal is not transported, one of dyspeptic pharmacological action.

The result shows, drug effect of the present invention and Health pill effect acquaintance, and medicine of the present invention also causes that to epinephrine intestinal propulsion suppresses antagonism is arranged, and Health pill except that epinephrine is caused mouse small intestine advance the effect that suppresses not obvious.

Two, medicine antidiarrheal of the present invention, analgesia and spasmolysis test.

1. the test of mouse anti diarrhoea shows: three dosage of medicine of the present invention and two dosage of Health pill cause the diarrhea of mouse model with Folium Sennae obvious diarrhea effect.Show as 6 hours accumulative total of administration group and rush down following just number of times than the obvious minimizing of matched group (P＜0.05 or P＜0.01), in the medicine wherein of the present invention, low dose of (3.70g/kg, 1.85g/kg), and Health pill low dose (1.85g/kg) after giving the agent of Folium Sennae diarrhea inducing second 2 hours and the 3rd were rushed down down just in 2 hours, and number of times also obviously reduces (P＜0.05 or P＜0.01) than matched group.

2. (1) hot-plate analgesic test shows: after medicine low dose of the present invention (1.85g/kg) administration 120 minutes, 90 minutes, 120 minutes pain thresholds were than the obvious rising of matched group (P＜0.05 or P＜0.01) after middle high dose (3.70g/kg, the 5.55g/) administration; Dosage in the Health pill (3.70g/kg), high dose administration 60 minutes, pain threshold was than the obvious rising of matched group (P＜0.05 or P＜0.01) in 90 minutes.

(2) test of acetic acid twisting method shows, each dosage group of medicine of the present invention and Health pill and matched group are relatively, the equal no significant difference incubation period of writhing response (P＞0.05), medicine high dose group of the present invention (5.55g/kg) is turned round the body number of times and is obviously reduced (P＜0.05) than matched group, two dosage groups of Health pill also have certain minimizing, but difference not significantly (P＞0.05).

The result shows that medicine of the present invention and Health pill have certain analgesic activity, but onset is slow and effect a little less than.

3. the test of isolated rabbit small intestinal and stripped small intestine of guinea pig spasmolysis shows that medicine doses of the present invention causes that to acecoline the spastic contraction of isolated rabbit ileum has certain antagonism.The spastic contraction of guinea pig ileum that histamine phosphate is caused has tangible antagonism, and the tonicity of dosing metagaster obviously descends.

Results suggest, medicine of the present invention has certain spasmolysis, and the Health pill spasmolysis of same dose is not obvious.

Three, medicine Chinese People's Anti-Japanese Military and Political College's Mus acute gastric mucosal lesion of the present invention and to the influence of rat tolerance secretion

1. adopt the sticking damage model of touching of acidic alcohol rat acute stomach; observe the sticking effect of touching damage of anti-acute stomach of medicine of the present invention and Health pill; the result shows that three dosage of medicine of the present invention (0.925g/kg, 1.85g/kg, 33.70) and Health pill (1.85g/kg) can reduce obviously that the stomach of rat model is sticking touches damage index, and the stomach of point out two kinds of preparations that some foreign substance is caused glues to be touched acute injury protective effect is arranged.

2. adopt rat pylorus ligature law stomachial secretion test to show, in the medicine of the present invention in, low dosage (1.85,0.925g/kg) do not have tangible influence to the pylorus ligation rat tolerance secretion; High dose (3.70g/kg) shows as gastric secretion, total acid output obviously reduces than matched group, points out this dosage that gastric acid secretion is had inhibitory action.Health pill (1.85g/kg) does not have tangible influence to stomachial secretion.

Further set forth the preparation method of medicine of the present invention by the following examples.

Embodiment 1:

A. get prescription one: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, mix homogeneously, the polyethylene glycol 6000 that adds dry extract, 6 times of amounts of cyclodextrin inclusion compound: the polyethylene glycol 6000 and the polyethylene glycol 1500 mixture of polyethylene glycol 1500=3: 2, heating dissolves, adopting a speed is 25～75/min, splash into aqueous methyl-silicone oil: in the condensed fluid of liquid Paraffin=1: 3, promptly get drop pill.

Embodiment 2:

A. get prescription two: Ramulus Uncariae Cum Uncis 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated into an amount of drying, pulverizes, and gets the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, mix homogeneously adds the polyethylene glycol 6000 of dry extract, 8 times of amounts of cyclodextrin inclusion compound: the mixture of Macrogol 4000=5: 1, heating dissolves, adopting a speed is 60～75/min, splashes in the methyl-silicone oil, promptly gets drop pill.

Embodiment 3:

A. get prescription three: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 95.20g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil betacyclodextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, mix homogeneously adds Macrogol 4000, and heating dissolves, and adopting a speed is 65～70/min, splashes in the liquid paraffin, promptly gets drop pill.

Embodiment 4:

A. get prescription four: Ramulus Uncariae Cum Uncis 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 4 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 4 times, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated into an amount of drying, pulverizes, and gets the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, add dry extract, 4 times of amounts of cyclodextrin inclusion compound, polyethylene glycol 6000: the mixture of Macrogol 4000=3: 2, heating dissolves, and adopting a speed is 70～75/min, splashes in the liquid Paraffin, promptly gets drop pill.

Embodiment 5:

A. get prescription five: Ramulus Uncariae Cum Uncis 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Guangdong Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1 time extracted 4 hours, and the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 2 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, volatile oil, mix homogeneously adds polyethylene glycol 6000, and heating dissolves, and adopting a speed is 75～90/min, splashes in-10～10 ℃ of methyl-silicone oils, promptly gets drop pill.

Embodiment 6

A. get prescription six: Ramulus Uncariae Cum Uncis 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 3 times, each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 3 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, add dry extract, 5 times of amounts of cyclodextrin inclusion compound, polyethylene glycol 6000: the mixture of Macrogol 4000=3: 2, heating dissolves, and adopting a speed is 70～75/min, splash into methyl-silicone oil: in the condensing agent of liquid Paraffin=3: 1, promptly get drop pill.

Embodiment 7:

A. get prescription, it is standby with embodiment 3 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil is standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 2 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get dry extract, volatile oil, add dry extract, 6 times of amounts of volatile oil, polyethylene glycol 6000: the polyethylene glycol 6000 and the polyethylene glycol 1500 mixture of polyethylene glycol 1500=5: 2, heating dissolves, and adopting a speed is 40/min, splash in 5 ℃ of methyl-silicone oils, promptly get drop pill.

Embodiment 8:

A. get prescription, it is standby with embodiment 2 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1 time, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, add dry extract, 5 times of amounts of cyclodextrin inclusion compound, polyethylene glycol 6000: the mixture of Macrogol 4000=3: 2, heating dissolves, and adopting a speed is 65～75/min, splashes in 5 ℃ of liquid paraffin, promptly gets drop pill.

Embodiment 9:

A. get prescription, it is standby with embodiment 5 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 9 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 9 times of amounts, and each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 9 times of amounts, 99% ethanol extraction 3 times, and each 0.5～5 hour, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, add dry extract, 3 times of amounts of cyclodextrin inclusion compound, polyethylene glycol 6000: the mixture of Macrogol 4000=5: 2, heating dissolves, and adopting a speed is 50～60/min, splashes in the methyl-silicone oil, promptly gets drop pill.

Embodiment 10:

A. get prescription, it is standby with embodiment 6 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 30% ethanol extraction 2 times, and 5 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, add dry extract, 4 times of amounts of cyclodextrin inclusion compound, polyethylene glycol 6000: the mixture of Macrogol 4000=1: 4, heating dissolves, and adopting a speed is 75～80/min, splash into methyl-silicone oil: in liquid Paraffin=1: 3 condensed fluid, promptly get drop pill.

Embodiment 11:

A. get prescription, it is standby with embodiment 1 to write out a prescription;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil is standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3～8 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae be with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, each 0.5～4 hour, merge extractive liquid,,, reclaim the ethanol concentrated extracting solution to an amount of, drying is pulverized, the dry extract fine powder;

C. get dry extract, volatile oil, add the 7 times of dry extracts and the polyethylene glycol 6000 of volatile oil weight, the mixture of Macrogol 4000, polyethylene glycol 6000: Macrogol 4000 is 3: 1, heating dissolves, adopting a speed is 50～80/min, splash in-10～10 ℃ of methyl-silicone oils, promptly get drop pill.

Embodiment 12

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 8 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 8 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 8 times of amounts, 95% ethanol extraction 3 times, and each 4 hours, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, add 4 times of dry extracts, the polyethylene glycol 6000 of cyclodextrin inclusion compound weight, the mixture of Macrogol 4000, polyethylene glycol 6000: Macrogol 4000 is 3: 2, heating dissolves, adopting a speed is 40～50/min, splash in 0～10 ℃ of liquid paraffin, promptly get drop pill.

Embodiment 13

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3 times of amounts, and each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracted 0.5 hour with 3 times of amounts, 50% ethanol extraction 1 time, and merge extractive liquid, reclaims ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, add 6 times of dry extracts, the Macrogol 4000 of cyclodextrin inclusion compound weight, the mixture of polyethylene glycol 1500, Macrogol 4000: polyethylene glycol 1500 is 3: 2, heating dissolves, adopting a speed is 65～70/min, splash in the liquid paraffin, promptly get drop pill.

Embodiment 14

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil is standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 75% ethanol extraction 2 times, and 4 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. get dry extract, volatile oil, add 5 times of dry extracts, the polyethylene glycol 6000 of mixture of volatile oil, the mixture of Macrogol 4000, polyethylene glycol 6000: Macrogol 4000 is 4: 1, heating dissolves, adopting a speed is 35～40/min, splashes in the methyl-silicone oil, promptly gets drop pill.

Embodiment 15

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 6 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each 1.5 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 2 times with 80% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, the polyethylene glycol 6000 that adds dry extract, 10 times of amounts of cyclodextrin inclusion compound: the mixture of Macrogol 4000=3: 2, heating dissolves, and adopts that to drip speed be 70～75/min, splash into methyl-silicone oil: in the condensing agent of liquid Paraffin=3: 1, promptly get drop pill.

Embodiment 16

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 3 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1 time, each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 3 times with 50% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, the polyethylene glycol 6000 that adds dry extract, 5.5 times of amounts of cyclodextrin inclusion compound: the polyethylene glycol 6000 and the polyethylene glycol 1500 mixture of polyethylene glycol 1500=2: 3, heating dissolves, adopting a speed is 65～70/min, splash into aqueous methyl-silicone oil: in the condensed fluid of liquid Paraffin=1: 1, promptly get drop pill.

Embodiment 17

A. get prescription, it is standby with embodiment 4 to write out a prescription;

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is standby; Aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 3 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of, Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae of getting recipe quantity again extract 1 time with 95% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get dry extract, volatile oil, the polyethylene glycol 6000 that adds 5 times of amounts of dry extract: the mixture of Macrogol 4000=1: 1, heating dissolves, and adopts that to drip speed be 45～55/min, splash into methyl-silicone oil: in the condensed fluid of liquid Paraffin=4: 1, promptly get drop pill.

Embodiment 18

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is standby; Aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add 3.5 times of water gagings and extract 3 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of, Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae of getting recipe quantity again extract 1 time with 95% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get dry extract, volatile oil, add the polyethylene glycol 6000 of 20 times of amounts of dry extract: the mixture of Macrogol 4000=3: 1, heating dissolves, and adopts that to drip speed be 55/min, splashes in the methyl-silicone oil, promptly gets drop pill.

Embodiment 19

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 3.5 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, the Guangdong Massa Medicata Fermentata adds 6 times of water gagings and extracts 2 times, each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae is with 3.5 times of amounts, 90% concentration ethanol is extracted 1 time, extracted 3 hours, and reclaimed the ethanol concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, add the polyethylene glycol 6000 of dry extract, 6 times of amounts of cyclodextrin inclusion compound: the mixture of Macrogol 4000=2: 3, heating dissolves, and adopts that to drip speed be 65～75/min, splashes in the liquid Paraffin, promptly gets drop pill.

Embodiment 20

B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 6 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, the Guangdong Massa Medicata Fermentata adds 4 times of water gagings and extracts 2 times, each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae is with 6 times of amounts, 55% concentration ethanol is extracted 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;

C. get dry extract, cyclodextrin inclusion compound, the polyethylene glycol 6000 that adds dry extract, 8 times of amounts of cyclodextrin inclusion compound: the mixture of Macrogol 4000=5: 1, heating dissolves, and adopts that to drip speed be 65～75/min, splash into methyl-silicone oil: in the condensed fluid of liquid Paraffin=4: 1, promptly get drop pill.

Embodiment 21

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil is standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 12 times of amounts, and 3 hours for the first time, second and third time each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4.5 times of amounts, 55% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of; Drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder and volatile oil mix homogeneously, add the mixture of polyethylene glycol 6000, polyethylene glycol 1500, wherein polyethylene glycol 6000: polyethylene glycol 1500 is 3: 1, heating dissolves, adopting a speed is 20～80/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 22

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets betacyclodextrin embedding thing with the betacyclodextrin embedding of 4 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 60% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add the combination of PVP, carboxymethyl starch sodium, mix homogeneously adds 20% alcohol granulation, and consumption is 20% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add Polyethylene Glycol, mix homogeneously, tabletting, coating promptly gets tablet.

Embodiment 23

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil is standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 80% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;

C. with dry extract fine powder and volatile oil mix homogeneously, add polyethylene glycol 6000, heating dissolves, and adopting a speed is 90/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 23

B. the active component preparation method is with embodiment 1;

C. get dry extract, cyclodextrin inclusion compound, add polyethylene glycol 6000, heating dissolves, and adopting a speed is 90/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 24

B. the active component preparation method is with embodiment 2;

C. get dry extract, cyclodextrin inclusion compound, add Macrogol 4000, heating dissolves, and adopting a speed is 80/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 25

B. the active component preparation method is with embodiment 3;

C. get dry extract, cyclodextrin inclusion compound, add polyethylene glycol 1500, heating dissolves, and adopting a speed is 85/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 26

B. the active component preparation method is with embodiment 4;

C. get dry extract, cyclodextrin inclusion compound, add the mixture of polyethylene glycol 6000, polyethylene glycol 1500, the amount of adding is a polyethylene glycol 6000: polyethylene glycol 1500 is 3: 1, heating dissolves, adopting a speed is 20～80/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 27

B. the active component preparation method is with embodiment 5;

C. get dry extract, cyclodextrin inclusion compound, the polyethylene glycol 6000 that adds dry extract, 10 times of amounts of cyclodextrin inclusion compound: the mixture of Macrogol 4000=5: 1, heating dissolves, adopting a speed is 65～75/min, splash into condensed fluid (liquid Paraffin, or methyl-silicone oil: liquid Paraffin=in 4: 1, promptly get drop pill.

Embodiment 28

B. the active component preparation method is with embodiment 6;

C. get dry extract, cyclodextrin inclusion compound, the polyethylene glycol 6000 that adds dry extract, 4 times of amounts of cyclodextrin inclusion compound: the mixture of Macrogol 4000=1: 1, heating dissolves, and adopts that to drip speed be 45～55/min, splash into methyl-silicone oil: in the condensed fluid of liquid Paraffin=4: 1, promptly get drop pill.

Embodiment 29

B. the active component preparation method is with embodiment 13;

Embodiment 30

B. the active component preparation method is with embodiment 11;

C. get dry extract, cyclodextrin inclusion compound, add the polyethylene glycol 6000 of dry extract, 20 times of amounts of cyclodextrin inclusion compound: the mixture of Macrogol 4000=3: 1, heating dissolves, and adopts that to drip speed be 55/min, splashes in the methyl-silicone oil, promptly gets drop pill.

Embodiment 31

B. the active component preparation method is with embodiment 12;

C. get dry extract, cyclodextrin inclusion compound, add the polyethylene glycol 6000 of dry extract, 4 times of amounts of cyclodextrin inclusion compound: the mixture of Macrogol 4000=5: 1, heating dissolves, and adopts that to drip speed be 55～65/min, splashes in the methyl-silicone oil, promptly gets drop pill.

Embodiment 32

B. the active component preparation method is with embodiment 8;

Embodiment 33

B. the active component preparation method is with embodiment 5;

Embodiment 34

B. the active component preparation method is with embodiment 18;

C. get dry extract, cyclodextrin inclusion compound, add the polyethylene glycol 6000 of 3 times of dry extracts, cyclodextrin inclusion compound, heating dissolves, and adopting a speed is 80～90/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 35

B. the active component preparation method is with embodiment 20;

C. get dry extract, cyclodextrin inclusion compound, add 5 times of dry extracts, the polyethylene glycol 6000 of cyclodextrin inclusion compound, the mixture of Macrogol 4000, polyethylene glycol 6000: Macrogol 4000 is 4: 1, heating dissolves, adopting a speed is 35～40/min, splashes in the methyl-silicone oil, promptly gets drop pill.

Embodiment 36

B. the active component preparation method is with embodiment 22;

Embodiment 37

B. the active component preparation method is with embodiment 19;

Embodiment 38

B. the active component preparation method is with embodiment 1;

C. get dry extract, cyclodextrin inclusion compound, add 7 times of dry extracts, the polyethylene glycol 6000 of cyclodextrin inclusion compound weight, the mixture of Macrogol 4000, polyethylene glycol 6000: Macrogol 4000 is 3: 1, heating dissolves, adopting a speed is 50～80/min, splash in-10～10 ℃ of methyl-silicone oils, promptly get drop pill.

Embodiment 39

B. the active component preparation method is with embodiment 2;

Embodiment 40

B. the active component preparation method is with embodiment 3;

Embodiment 41

B. the active component preparation method is with embodiment 4;

C. get dry extract, cyclodextrin inclusion compound, add dry extract, 6 times of amounts of cyclodextrin inclusion compound, polyethylene glycol 6000: the mixture of Macrogol 4000=3: 2, heating dissolves, and adopting a speed is 45～55/min, splashes in 0 ℃ of liquid paraffin, promptly gets drop pill.

Embodiment 42

B. the active component preparation method is with embodiment 6;

C. get dry extract, cyclodextrin inclusion compound, add dry extract, 5 times of amounts of cyclodextrin inclusion compound, polyethylene glycol 6000: the mixture of Macrogol 4000=3: 2, heating dissolves, and adopting a speed is 65～75/nin, splashes in 5 ℃ of liquid paraffin, promptly gets drop pill.

Embodiment 43

B. the active component preparation method is with embodiment 13;

C. get dry extract, cyclodextrin inclusion compound, add dry extract, 6 times of amounts of cyclodextrin inclusion compound, polyethylene glycol 6000: the polyethylene glycol 6000 and the polyethylene glycol 1500 mixture of polyethylene glycol 1500=5: 2, heating dissolves, and adopting a speed is 40/min, splash in 5 ℃ of methyl-silicone oils, promptly get drop pill.

Embodiment 44

B. the active component preparation method is with embodiment 15;

Embodiment 45

B. the active component preparation method is with embodiment 12;

Embodiment 46

B. the active component preparation method is with embodiment 7;

Embodiment 47

B. the active component preparation method is with embodiment 14;

Embodiment 48

B. the active component preparation method is with embodiment 5;

C. get dry extract, cyclodextrin inclusion compound, mix homogeneously adds the polyethylene glycol 6000 of dry extract, 10 times of amounts of cyclodextrin inclusion compound: the mixture of Macrogol 4000=1: 4, heating dissolves, adopting a speed is 65～75/min, splashes in the liquid Paraffin, promptly gets drop pill.

Embodiment 49

B. the active component preparation method is with embodiment 18;

Embodiment 50

B. the active component preparation method is with embodiment 20;

Embodiment 51

B. the active component preparation method is with embodiment 22;

C. get dry extract, cyclodextrin inclusion compound, add the polyethylene glycol 6000 of 25 times of dry extracts, cyclodextrin inclusion compound amount, heating dissolves, and adopting a speed is 80/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 52

B. the active component preparation method is with embodiment 19;

C. get dry extract, cyclodextrin inclusion compound, add the Macrogol 4000 of 30 times of dry extracts, cyclodextrin inclusion compound amount, heating dissolves, and adopting a speed is 45～50/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 53

B. the active component preparation method is with embodiment 1;

C. get dry extract, cyclodextrin inclusion compound, add the mixture of 10 times of dry extracts, cyclodextrin inclusion compound amount, polyethylene glycol 6000: Macrogol 4000 is 2: 1, and heating dissolves, and adopting a speed is 50/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 54

B. the active component preparation method is with embodiment 2;

C. get dry extract, cyclodextrin inclusion compound, add the Macrogol 4000 of dry extract, 15 times of amounts of cyclodextrin inclusion compound, heating dissolves, and adopting a speed is 30/min, splashes in the condensed fluid, promptly gets drop pill.

Embodiment 55

B. the active component preparation method is with embodiment 3;

C. get dry extract, cyclodextrin inclusion compound, add dry extract, 20 times of amounts of cyclodextrin inclusion compound, polyethylene glycol 6000: the mixture of Macrogol 4000=3: 2, heating dissolves, adopting a speed is 40/min, splash into liquid Paraffin, or methyl-silicone oil: liquid Paraffin is in 3: 1 the condensed fluid, promptly to get drop pill.

Claims

One kind have induce sweat, dry and in the preparation method of Chinese medicine composition, its feature comprises the steps:

A. get 15.50～55.80 parts of crude drug Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil is standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder and volatilization mix homogeneously, preparation cost invention medicine activity component.
2. as claimed in claim 1 induce sweat, dry and in the preparation method of Chinese medicine composition, its feature comprises the steps:

A. get 27.17～41.20 parts of crude drug Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and are standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1～4 time, each 0.5～5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1～4 time, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder and volatile oil mix homogeneously, preparation cost invention medicine activity component.
3. as claimed in claim 2 induce sweat, dry and in the preparation method of Chinese medicine composition, its feature comprises the steps:

A. it is standby to get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;

B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil is standby; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1～3 time, each 0.5～3 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1～3 time, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;

C. with dry extract fine powder and volatile oil mix homogeneously, preparation cost invention medicine activity component.
As claim 1～3 arbitrary described induce sweat, dry and in the preparation method of Chinese medicine composition, it is characterized in that among the step b that volatile oil is with the dextrin embedding of 2～9 times of amounts; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 30～99% ethanol extractions.
5. as claimed in claim 4 induce sweat, dry and in the preparation method of Chinese medicine composition, it is characterized in that volatile oil among the step b is with the dextrin embedding of 3～8 times of amounts; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 50～95% ethanol extractions.
As induce sweat, dry as described in the claim 5 and in the preparation method of Chinese medicine composition, it is characterized in that volatile oil among the step b is with the dextrin embedding of 3～8 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3～8 times of amounts, each 1～2 hour; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, each 0.5～4 hour.
7. induce sweat, dry as claim 6 and in the preparation method of Chinese medicine composition, it is characterized in that volatile oil among the step b is with the dextrin embedding of 3.5～6 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, each 1～2 hour; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 3.5～6 times of amounts, 55～90% ethanol extractions 1～2 time, each 1～3 hour.
As induce sweat, dry as described in the claim 7 and in the preparation method of Chinese medicine composition, it is characterized in that volatile oil among the step b is with the dextrin embedding of 5.5 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, 2 hours for the first time, 1 hour for the second time; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 4 times of amounts, 70% ethanol extraction 2 times, 2 hours for the first time, 1 hour for the second time.
One kind induce sweat, dry and in Chinese medicine preparation, it is characterized in that the weighting profit requires 1～8 arbitrary dry extract that makes and volatile oil or cyclodextrin inclusion compound and drop pill adjuvant commonly used to mix, drip system according to the drop pill conventional method, promptly get drop pill.
As induce sweat, dry as described in the claim 9 and in Chinese medicine preparation, it is characterized in that in the mixture of dry extract and volatile oil or cyclodextrin inclusion compound, add the one or any combination in polyethylene glycol 6000, Macrogol 4000, the polyethylene glycol 1500, heating dissolves, adopting a speed is 15～90/min, splash in the condensed fluid, promptly get drop pill.
11. as induce sweat, dry as described in the claim 10 and in Chinese medicine preparation, it is characterized in that in the mixture of dry extract and volatile oil or cyclodextrin inclusion compound, add polyethylene glycol 6000, the one or any combination of Macrogol 4000, heating dissolves, adopting a speed is 20～80/min, splash in the condensed fluid, promptly get drop pill.
12. as induce sweat, dry as described in the claim 11 and in Chinese medicine preparation, it is characterized in that in the mixture of dry extract and volatile oil or cyclodextrin inclusion compound, the polyethylene glycol 6000 that adds dry extract fine powder and volatile oil or 1～30 times of amount of dextrin embedding thing: Macrogol 4000=1～5: 1～4 mixture, heating dissolves, adopting a speed is 25～75/min, splash into liquid Paraffin, or methyl-silicone oil or methyl-silicone oil: liquid Paraffin=1～4: in 1～3 the condensed fluid, promptly get drop pill.
13. as induce sweat, dry as described in the claim 12 and in Chinese medicine preparation, it is characterized in that in the mixture of dry extract and volatile oil or cyclodextrin inclusion compound, the polyethylene glycol 6000 that adds dry extract fine powder and volatile oil or 20 times of amounts of dextrin embedding thing: the mixture of Macrogol 4000=3: 2, heating dissolves, adopting a speed is 40/min, splash into liquid Paraffin, or methyl-silicone oil: liquid Paraffin is in 3: 1 the condensed fluid, promptly to get drop pill.
14. as induce sweat, dry as described in the claim 10 and in Chinese medicine preparation, it is characterized in that dextrin wherein is a betacyclodextrin.