CN100998778B - Traditional Chinese medicine tablets for relieving exterior syndrome, removing dampness regulating the stomach and its preparing method - Google Patents
Traditional Chinese medicine tablets for relieving exterior syndrome, removing dampness regulating the stomach and its preparing method Download PDFInfo
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Abstract
A Chinese medicine in the form of tablet for relieving exterior syndrome, dispelling dampness and regulating stomach is prepared from 16 Chinese-medicinal materials including uncaria stem with hooks, magnolia bark, trichosanthes root, tuckahoe, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of have induce sweat, dry and in Chinese medicinal tablet and preparation method thereof.
Background technology
Stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset, dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache are clinical common symptoms, these symptoms can be caused by multiple reason.In Song dynasty " formulary of peaceful benevolent dispensary " these symptoms are put down in writing to some extent, and the prescription of ageratum side as treatment is provided.Ageratum side is described as " heat-damp in summer panacea " by ancient Chinese medicine doctor.This side have induce sweat, damp eliminating and in effect, be usually used in treating the treatment of affection of exogenous wind-cold, internal injury humidity hysteresis, stomachache vomiting and diarrhoea clinically, mainly be with stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache etc. are clinical manifestation, also are widely used at present the treatments such as common cold of gastrointestinal type, acute chronic enteritis of modern medicine.Health pill is a kind of traditional Chinese medicine, is the novel formulation that develops on the basis of the former technology of the positive invigorating oral liquid of traditional Radix agastaches, and China's " pharmacopeia " includes it wherein already.Health pill have induce sweat, damp eliminating and in function; Be mainly used in stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, the treatment of fever and headache.The Health pill of putting down in writing in the pharmacopeia adopts the method for making of " each pulverizing medicinal materials; general ball; coating ", its productive labor intensity is big, with low content of technology, prescription Chinese medicine effective ingredient is not extracted, thereby cause Health pill to exist the medicine active ingredient in gastrointestinal dissolution rate and absorbance reduction, soak time prolongs, and onset is slow, and because Health pill bad smell when taking can make the patient produce resentment.
Chinese invention patent number 200410027334.4 titles are made and are protected the Ji sheet, decoct with water owing to Ramulus Uncariae Cum Uncis in its technology that adopts, be not easy to extract fat-soluble effective ingredient in the Ramulus Uncariae Cum Uncis, and multiple medical material as: Six-element medicines such as the Radix Aucklandiae, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Pogostemonis adopt CO respectively
2The process more complicated of extraction, the cycle of finishing production is long, and cost is higher.
Tablet grows up on pill uses the basis, and that tablet has become is wide in variety, output is big, purposes is wide, uses and stores and transports conveniently, one of steady quality dosage form, tablet all accounts for more than 1/3 in the preparation that the pharmacopeia of China and other many countries is recorded, and its application is very wide.Tablet has the following advantages: dosage is accurate; Steady quality; Carry, transport, take more convenient; Mechanization is produced, and output is big, and cost is low, and " sanitary standard " also reaches easily.
Summary of the invention
The purpose of this invention is to provide a kind of have induce sweat, dry and in Chinese medicinal tablet.
Another object of the present invention provide a kind of have induce sweat, dry and in active constituents of medicine.
Another object of the present invention provide a kind of have induce sweat, dry and in the preparation method of Chinese medicinal tablet.
Medicine of the present invention is to be made by Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis.
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through the inventor, and each component raw material all has curative effect preferably at the following weight parts ratio range: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss.
Preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss.
Best each component raw material medicine of pharmaceutical composition of the present invention has curative effect preferably in the following weight parts proportioning: 34.10 parts of Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss.
The preparation of the active component of the present composition and preparation can adopt following method: one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, but this can not limit protection scope of the present invention.
The proportioning that following medicine activity component extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine weight proportion is a dosage range provided by the present invention.
A. it is standby to get crude drug Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, preparation cost invention medicine activity component.
Preferably, the active component preparation method of Chinese medicine composition of the present invention, its feature comprises the steps:
A. it is standby to get crude drug Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1～4 time, each 0.5～5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1～4 time, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, preparation cost invention medicine activity component.
Further preferred, the preparation method of Chinese medicine composition active component of the present invention, its feature comprises the steps:
A. it is standby to get crude drug Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1～3 time, each 0.5～3 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1～3 time, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, preparation cost invention medicine activity component.
The preparation method of Chinese medicine composition active component of the present invention, volatile oil is with the dextrin embedding of 2～9 times of amounts among the step b; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 30～99% ethanol extractions.
The preparation method of preferred Chinese medicine composition active component of the present invention, the volatile oil among the step b is with the dextrin embedding of 3～8 times of amounts; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 50～95% ethanol extractions.
The further preparation method of preferred Chinese medicine composition active component of the present invention, the volatile oil among the step b is with the dextrin embedding of 3～8 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3～8 times of amounts, each 1～2 hour; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, each 0.5～4 hour.
The preparation method of further preferred Chinese medicine composition active component of the present invention, the volatile oil among the step b is with the dextrin embedding of 3.5～6 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, each 1～2 hour; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 3.5～6 times of amounts, 55～90% ethanol extractions 1～2 time, each 1～3 hour.
The preparation method of best Chinese medicine composition active component of the present invention, the volatile oil among the step b is with the dextrin embedding of 5.5 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, 2 hours for the first time, 1 hour for the second time; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 4 times of amounts, 70% ethanol extraction 2 times, 2 hours for the first time, 1 hour for the second time.
The preparation method of Chinese medicine composition active component of the present invention, the dextrin among the step b are betacyclodextrin.
The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, makes any preparation on the pharmaceutics; Be prepared into any common formulations as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as tablet, sugar coated tablet, film coated tablet, enteric coated tablet, powder, capsule, soft capsule, pill, electuary, oral liquid, granule, drop pill, micropill, intramuscular injection agent, instillation, unguentum, ointment, plaster etc.; The best is made tablet, drop pill, oral liquid, granule, capsule, soft capsule.
The preparation method of medicinal tablet of the present invention, dry extract, the cyclodextrin inclusion compound of getting above-mentioned acquisition mix tabletting with tablet adjuvant commonly used.
Preferably, the preparation method of tablet of the present invention is got dry extract, cyclodextrin inclusion compound and the crospovidone of above-mentioned acquisition, and mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
The specific embodiment
In order to understand the present invention better, logical below test example is further set forth the beneficial effect of medicine of the present invention.These test examples comprise the pharmacodynamics test of medicine of the present invention.Below used medicine prepares according to embodiment 15 methods in the test.
One, medicine of the present invention is to the mice gastric emptying, the influence of intestinal propulsion
Medicine of the present invention adopts the production technology of pressing embodiment 15 to produce and obtains, and grinds, and adds water and becomes pasty state.
Control drug: Health pill, commercially available, adopt identical pastel.
1. adopt the semi-solid gastric emptying experimental technique of mice, observe medicine of the present invention normal mouse and dopamine hydrochloride are caused the influence of mice delayed gastric emptying, the result shows: (1) medicine of the present invention, Health pill are not obvious to the normal mouse gastric emptying.(2) the simple dopamine hydrochloride group of nutrition paste residual quantity significantly reduces (P＜0.01 or P＜0.05) in two dosage of medicine of the present invention (1.85g/kg, 3.70g/kg), Health pill (1.85g/kg), fourth woods (5mg/kg) stomach, and medicine of the present invention, the Health pill of prompting doses all have antagonism to the mice delayed gastric emptying that dopamine hydrochloride causes.
2. adopt mouse small intestine charcoal end propulsion trial, observe medicine of the present invention and contrast medicine Health pill, and at neostigmine, epinephrine, atropine cause that mouse small intestine advances antagonism hyperfunction or that suppress the propulsive influence of small intestine movement of mice.The result shows that (1) medicine low dose of the present invention has the propulsive effect of the small intestine movement of mice of quickening, and two dosage effects of middle and high dosage and Health pill are not obvious.(2) small intestinal that causes at neostigmine of two dosage of middle and high dosage of medicine of the present invention and Health pill is hyperfunction an inhibitory action.(3) medicine high dose of the present invention causes that to atropine intestinal propulsion suppresses antagonism is arranged, and two dosage effects of little, middle dosage and Health pill are not obvious.(4) three dosage of medicine of the present invention cause that at epinephrine intestinal propulsion suppresses antagonism is arranged, and the Health pill effect is not obvious.
Above result shows, medicine doses of the present invention causes that at neostigmine mouse small intestine advances the hyperfunction inhibitory action that has, and the mouse small intestine that epinephrine or atropine are caused advances and suppresses also to have certain antagonism.Results suggest, medicine of the present invention has regulating action to mice gastric emptying, intestinal motility disorder.One of symptom that medicine of the present invention cures mainly is a gastrointestinal upset, dyspepsia, and both all can show the gastrointestinal motility dysfunction, this effect should be that its treatment gastrointestinal is not transported, one of dyspeptic pharmacological action.
The result shows, drug effect of the present invention and Health pill effect acquaintance, and medicine of the present invention also causes that to epinephrine intestinal propulsion suppresses antagonism is arranged, and Health pill except that epinephrine is caused mouse small intestine advance the effect that suppresses not obvious.
Two, medicine antidiarrheal of the present invention, analgesia and spasmolysis test.
1. the test of mouse anti diarrhoea shows: three dosage of medicine of the present invention and two dosage of Health pill cause the diarrhea of mouse model with Folium Sennae obvious diarrhea effect.Show as 6 hours accumulative total of administration group and rush down following just number of times than the obvious minimizing of matched group (P＜0.05 or P＜0.01), in the medicine wherein of the present invention, low dose of (3.70g/kg, 1.85g/kg), and Health pill low dose (1.85g/kg) after giving the agent of Folium Sennae diarrhea inducing second 2 hours and the 3rd were rushed down down just in 2 hours, and number of times also obviously reduces (P＜0.05 or P＜0.01) than matched group.
2. (1) hot-plate analgesic test shows: after medicine low dose of the present invention (1.85g/kg) administration 120 minutes, 90 minutes, 120 minutes pain thresholds were than the obvious rising of matched group (P＜0.05 or P＜0.01) after middle high dose (3.70g/kg, the 5.55g/) administration; Dosage in the Health pill (3.70g/kg), high dose administration 60 minutes, pain threshold was than the obvious rising of matched group (P＜0.05 or P＜0.01) in 90 minutes.
(2) test of acetic acid twisting method shows, each dosage group of medicine of the present invention and Health pill and matched group are relatively, the equal no significant difference incubation period of writhing response (P＞0.05), medicine high dose group of the present invention (5.55g/kg) is turned round the body number of times and is obviously reduced (P＜0.05) than matched group, two dosage groups of Health pill also have certain minimizing, but difference not significantly (P＞0.05).
The result shows that medicine of the present invention and Health pill have certain analgesic activity, but onset is slow and effect a little less than.
3. the test of isolated rabbit small intestinal and stripped small intestine of guinea pig spasmolysis shows that medicine doses of the present invention causes that to acecoline the spastic contraction of isolated rabbit ileum has certain antagonism.The spastic contraction of guinea pig ileum that histamine phosphate is caused has tangible antagonism, and the tonicity of dosing metagaster obviously descends.
Results suggest, medicine of the present invention has certain spasmolysis, and the Health pill spasmolysis of same dose is not obvious.
Three, medicine Chinese People's Anti-Japanese Military and Political College's Mus acute gastric mucosal lesion of the present invention and to the influence of rat tolerance secretion
1. adopt the sticking damage model of touching of acidic alcohol rat acute stomach; observe the sticking effect of touching damage of anti-acute stomach of medicine of the present invention and Health pill; the result shows that three dosage of medicine of the present invention (0.925g/kg, 1.85g/kg, 33.70) and Health pill (1.85g/kg) can reduce obviously that the stomach of rat model is sticking touches damage index, and the stomach of point out two kinds of preparations that some foreign substance is caused glues to be touched acute injury protective effect is arranged.
2. adopt rat pylorus ligature law stomachial secretion test to show, in the medicine of the present invention in, low dosage (1.85,0.925g/kg) do not have tangible influence to the pylorus ligation rat tolerance secretion; High dose (3.70g/kg) shows as gastric secretion, total acid output obviously reduces than matched group, points out this dosage that gastric acid secretion is had inhibitory action.Health pill (1.85g/kg) does not have tangible influence to stomachial secretion.
Further set forth the preparation method of medicine of the present invention by the following examples.
Embodiment 1:
A. get prescription one: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.
Embodiment 2:
A. get prescription two: Ramulus Uncariae Cum Uncis 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated into an amount of drying, pulverizes, and gets the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.
Embodiment 3:
A. get prescription three: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 95.20g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil betacyclodextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.45g, coating or bag film-coat promptly do not get tablet.
Embodiment 4:
A. get prescription four: Ramulus Uncariae Cum Uncis 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 4 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 4 times, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated into an amount of drying, pulverizes, and gets the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add starch, mix, granulate tabletting.
Embodiment 5:
A. get prescription five: Ramulus Uncariae Cum Uncis 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Guangdong Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1 time extracted 4 hours, and the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 2 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with concentrate, dextrin embedding thing and cane sugar powder, dextrin mixing, tabletting.
Embodiment 6
A. get prescription six: Ramulus Uncariae Cum Uncis 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 3 times, each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 3 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with concentrate, dextrin embedding thing and cyclodextrin, tabletting.
Embodiment 7:
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 2 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. concentrate, dextrin embedding thing are mixed tabletting with cane sugar powder, dextrin, soluble starch.
Embodiment 8:
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1 time, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, tabletting.
Embodiment 9:
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 9 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 9 times of amounts, and each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 9 times of amounts, 99% ethanol extraction 3 times, and each 0.5～5 hour, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, mix, granulate tabletting with soluble starch.
Embodiment 10:
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 30% ethanol extraction 2 times, and 5 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, tabletting.
Embodiment 11:
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3～8 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3～8 times of amounts, and each 1～2 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae be with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, each 0.5～4 hour, merge extractive liquid,,, reclaim the ethanol concentrated extracting solution to an amount of, drying is pulverized, the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add dextrin, mix homogeneously adds 80% alcohol granulation, and consumption is 80% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.
Embodiment 12
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 8 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 8 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 8 times of amounts, 95% ethanol extraction 3 times, and each 4 hours, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add 5% alcohol granulation, consumption is 2% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying; Add silica gel, mix homogeneously, tabletting, coating promptly gets tablet.
Embodiment 13
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3 times of amounts, and each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracted 0.5 hour with 3 times of amounts, 50% ethanol extraction 1 time, and merge extractive liquid, reclaims ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add 75% alcohol granulation, consumption is 60% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add magnesium stearate, Polyethylene Glycol, mix homogeneously, tabletting, coating or coating not promptly get tablet.
Embodiment 14
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 5 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 75% ethanol extraction 2 times, and 4 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add PVP, mix homogeneously adds 75% alcohol granulation, and consumption is 60% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add Polyethylene Glycol, mix homogeneously, tabletting promptly gets tablet.
Embodiment 15
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 6 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each 1.5 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 2 times with 80% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add starch, mix homogeneously adds 10% alcohol granulation, and consumption is 60% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add magnesium stearate, mix homogeneously, tabletting, coating or coating not promptly get tablet.
Embodiment 16
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 3 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1 time, each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 3 times with 50% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously; Add dextrin, PVP, carboxymethyl starch sodium, mix homogeneously adds 20% alcohol granulation, and consumption is 40% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add silica gel, mix homogeneously, tabletting, coating or coating not promptly get tablet.
Embodiment 17
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 8 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 3 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 1 time with 95% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously; Add starch and PVP, mix homogeneously adds 70% alcohol granulation, and consumption is 50% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add Polyethylene Glycol, mix homogeneously, tabletting, coating promptly gets tablet.
Embodiment 18
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 8 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, the Guangdong Massa Medicata Fermentata adds 3.5 times of water gagings and extracts 3 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 1 time with 95% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add dextrin, mix homogeneously adds 10% alcohol granulation, and consumption is 15% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add Polyethylene Glycol, mix homogeneously, tabletting, coating or coating not promptly get tablet.
Embodiment 19
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 3.5 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, the Guangdong Massa Medicata Fermentata adds 6 times of water gagings and extracts 2 times, each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae is with 3.5 times of amounts, 90% concentration ethanol is extracted 1 time, extracted 3 hours, and reclaimed the ethanol concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add the combination of an amount of dextrin, lactose, mix homogeneously adds 40% alcohol granulation, and consumption is 25% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add magnesium stearate, mix homogeneously, tabletting, coating promptly gets tablet.
Embodiment 20
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 6 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, the Guangdong Massa Medicata Fermentata adds 4 times of water gagings and extracts 2 times, each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae is with 6 times of amounts, 55% concentration ethanol is extracted 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add dextrin, lactose, PVP, mix homogeneously adds 80% alcohol granulation, and consumption is 80% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add Polyethylene Glycol, mix homogeneously, tabletting, coating promptly gets tablet.
Embodiment 21
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets betacyclodextrin embedding thing with the betacyclodextrin embedding of 3 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 12 times of amounts, and 3 hours for the first time, second and third time each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4.5 times of amounts, 55% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of; Drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add carboxymethyl starch sodium, mix homogeneously adds 70% alcohol granulation, and consumption is 5% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add magnesium stearate, mix homogeneously, tabletting, coating does not promptly get tablet.
Embodiment 22
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets betacyclodextrin embedding thing with the betacyclodextrin embedding of 4 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 60% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add the combination of PVP, carboxymethyl starch sodium, mix homogeneously adds 20% alcohol granulation, and consumption is 20% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add Polyethylene Glycol, mix homogeneously, tabletting, coating promptly gets tablet.
Embodiment 23
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets betacyclodextrin embedding thing with the betacyclodextrin embedding of 5 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 80% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. with dry extract fine powder and dextrin embedding thing mix homogeneously, add carboxymethyl starch sodium, mix homogeneously adds 40% alcohol granulation, and consumption is 10% of dry extract fine powder, dextrin embedding thing and a supplementary product consumption; With particle drying, add Polyethylene Glycol, mix homogeneously, tabletting promptly gets tablet.
Claims (11)
- One kind induce sweat, dry and in the preparation method of Chinese medicine composition, its feature comprises the steps:A. get 15.50～55.80 parts of crude drug Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;C. with dry extract fine powder and dextrin embedding thing mix homogeneously, preparation cost invention medicine activity component.
- 2. as claimed in claim 1 induce sweat, dry and in the preparation method of Chinese medicine composition, its feature comprises the steps:A. get 27.17～41.20 parts of crude drug Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1～4 time, each 0.5～5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1～4 time, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;C. with dry extract fine powder and dextrin embedding thing mix homogeneously, preparation cost invention medicine activity component.
- 3. as claimed in claim 2 induce sweat, dry and in the preparation method of Chinese medicine composition, its feature comprises the steps:A. it is standby to get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1～3 time, each 0.5～3 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1～3 time, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;C. with dry extract fine powder and dextrin embedding thing mix homogeneously, preparation cost invention medicine activity component.
- 4. as claimed in claim 3 induce sweat, dry and in the preparation method of Chinese medicine composition, it is characterized in that among the step b that volatile oil is with the dextrin embedding of 2～9 times of amounts; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 30～99% ethanol extractions.
- 5. as claimed in claim 4 induce sweat, dry and in the preparation method of Chinese medicine composition, it is characterized in that volatile oil among the step b is with the dextrin embedding of 3～8 times of amounts; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 50～95% ethanol extractions.
- As induce sweat, dry as described in the claim 5 and in the preparation method of Chinese medicine composition, it is characterized in that volatile oil among the step b is with the dextrin embedding of 3～8 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3～8 times of amounts, each 1～2 hour; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, each 0.5～4 hour.
- 7. induce sweat, dry as claim 6 and in the preparation method of Chinese medicine composition, it is characterized in that volatile oil among the step b is with the dextrin embedding of 3.5～6 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, each 1～2 hour; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 3.5～6 times of amounts, 55～90% ethanol extractions 1～2 time, each 1～3 hour.
- As induce sweat, dry as described in the claim 7 and in the preparation method of Chinese medicine composition, it is characterized in that volatile oil among the step b is with the dextrin embedding of 5.5 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, 2 hours for the first time, 1 hour for the second time; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae were with 4 times of amounts, 70% ethanol extraction 2 times, 2 hours for the first time, 1 hour for the second time.
- As claim 1～8 arbitrary described induce sweat, dry and in the preparation method of Chinese medicine composition, it is characterized in that the dextrin among the step b is a betacyclodextrin
- 10. induce sweat, dry as described in arbitrary as claim 9 and in the preparation method of Chinese medicine composition, it is characterized in that getting dry extract, cyclodextrin inclusion compound, add tablet adjuvant commonly used, mixing is with 10%～80% alcohol granulation, drying, granulate, tabletting.
- 11. as induce sweat, dry as described in the claim 10 and in the preparation method of Chinese medicine composition, it is characterized in that with dry extract, cyclodextrin inclusion compound, with the crospovidone mixing, with 10%～80% alcohol granulation, drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.
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| CN1583086A (en) * | 2004-05-27 | 2005-02-23 | 广州王老吉药业股份有限公司 | Chinese medicine for relieving exterior syndrome, regulating stomach and eliminatnig dampness and its production |
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| CN1583086A (en) * | 2004-05-27 | 2005-02-23 | 广州王老吉药业股份有限公司 | Chinese medicine for relieving exterior syndrome, regulating stomach and eliminatnig dampness and its production |
Non-Patent Citations (3)
| Title |
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| 中华人民共和国卫生部药典委员会.《保济丸》.《中华人民共和国卫生部药品标准中药成方制剂第二十册》.1998,194-195. * |
| 中华人民共和国卫生部药典委员会.《保济口服液》.《中华人民共和国卫生部药品标准中药成方制剂第十七册》.1998,171-172. * |
| 李棣华.《厚朴正交提取工艺的初步研究》.《天津中医药》.2005,第44卷(第7期),68-70. * |
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