CN100998784B

CN100998784B - Preparing method of traditional Chinese medicine composition tablet for treating gastrointestinal disease

Info

Publication number: CN100998784B
Application number: CN2006100111796A
Authority: CN
Inventors: 李祖泽; 施少斌; 郑荣波; 沈军; 黄晓丹
Original assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Current assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Priority date: 2006-01-12
Filing date: 2006-01-12
Publication date: 2011-05-11
Anticipated expiration: 2026-01-12
Also published as: CN100998784A

Abstract

A Chinese medicine in the form of tablet for treating gastrointestinal disease is prepared from 16 Chinese-medicinal materials including uncaria stem with hooks, magnolia bark, trichosanthes root, tuckahoe, etc. Its preparing process is also disclosed.

Description

A kind of preparation method for the treatment of the gastrointestinal disease Chinese medicine composition

Technical field

The present invention relates to field of medicaments, particularly relate to a kind of treatment gastrointestinal disease Chinese medicine composition and preparation method thereof.

Background technology

Stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset, dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache are clinical common symptoms, and these symptoms can cause by multiple reason, and the double sense wind and cold of regarding sb. as an outsider of gastrointestinal disease is one of the main reasons wherein.In Song dynasty " formulary of peaceful benevolent dispensary " these symptoms are put down in writing to some extent, and the prescription of ageratum side as treatment is provided.Ageratum side is described as " heat-damp in summer panacea " by ancient Chinese medicine doctor.This side have induce sweat, damp eliminating and in effect, be usually used in treating the treatment of affection of exogenous wind-cold, internal injury humidity hysteresis, stomachache vomiting and diarrhoea clinically, mainly be with stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache etc. are clinical manifestation, also are widely used at present the treatments such as common cold of gastrointestinal type, acute chronic enteritis of modern medicine.Health pill is the novel formulation that develops on the basis of the former technology of the positive invigorating oral liquid of traditional Radix agastaches, and China's " pharmacopeia " includes it wherein already.Health pill have induce sweat, damp eliminating and in function; Be mainly used in stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, the treatment of fever and headache.The Health pill of putting down in writing in the pharmacopeia adopts the method for making of " each pulverizing medicinal materials; general ball; coating ", thereby it is low to cause Health pill to exist the medicine active ingredient, reduce at gastrointestinal dissolution rate and absorbance, soak time prolongs, and onset is slow, and because Health pill bad smell when taking can make the patient produce resentment.

Tablet grows up on pill uses the basis, and that tablet has become is wide in variety, output is big, purposes is wide, uses and stores and transports conveniently, one of steady quality dosage form, tablet all accounts for more than 1/3 in the preparation that the pharmacopeia of China and other many countries is recorded, and its application is very wide.Tablet has the following advantages: dosage is accurate; Steady quality; Carry, transport, take more convenient; Mechanization is produced, and output is big, and cost is low, and " sanitary standard " also reaches easily.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition tablet for the treatment of gastrointestinal disease.

Another object of the present invention provides a kind of preparation method for the treatment of the gastrointestinal disease active component.

Another object of the present invention provides a kind of preparation method for the treatment of the Chinese medicine composition tablet of gastrointestinal disease.

Pharmaceutical composition of the present invention is to be made by Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis.

The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss.

Preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss.

Best each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably in the following weight parts scope: 34.10 parts of Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss.

Medicine of the present invention can will be made any preparation on the pharmaceutics.

The preparation of the active component of the present composition and preparation can adopt following method: one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, but this can not limit protection scope of the present invention.

The weight portion proportioning that following medicine activity component extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine weight portion proportioning is a dosage range provided by the present invention.

Preparation method one:

The preparation method of Chinese medicine composition of the present invention comprises the steps:

A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 1～10 times of extract amount, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 25～90 ℃ of temperature are extracted each 0.2～3 hour 1～3 time; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 4～12 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, standby; With dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder mix homogeneously, make medicine activity component of the present invention.

Preferably, the preparation method of Chinese medicine composition of the present invention comprises the steps:

A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2～7 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 35～80 ℃ of temperature are extracted each 0.5～2 hour 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 6～10 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, standby; With dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder mix homogeneously, make medicine activity component of the present invention.

Best, the preparation method of Chinese medicine composition of the present invention comprises the steps:

A. it is standby to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 65 ℃ of temperature are extracted each 1 hour 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, standby; With dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder mix homogeneously, make medicine activity component of the present invention.

Active component of the present invention can be made any preparation on the pharmaceutics; The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, be prepared into any common formulations as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as tablet, sugar coated tablet, film coated tablet, enteric coated tablet, powder, capsule, soft capsule, pill, electuary, oral liquid, granule, drop pill, micropill, intramuscular injection agent, instillation, unguentum, ointment, plaster etc.; The best is made tablet, drop pill, oral liquid, granule, capsule, soft capsule.

The preparation method of tablet of the present invention, wherein the dry extract that makes of step b, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder mix tabletting with tablet adjuvant commonly used.

Preferably, the preparation method of tablet of the present invention, the dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder and the crospovidone that make of step b wherein, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Further preferred, the preparation method of tablet of the present invention, the dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder and the crospovidone that make of step b wherein, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.2～1g, coating or bag film-coat promptly do not get tablet.

Best, the preparation method of tablet of the present invention, the dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder and the crospovidone that make of step b wherein, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.45g, coating or bag film-coat promptly do not get tablet.

Preparation method two:

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; The paste ring spermatophore that volatile oil is added 1～10 times of extract amount closes, and gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;

C. qinghuo reagent I, clear paste II, cyclodextrin clathrate mix homogeneously are made medicine activity component of the present invention.

The preparation method of preferred Chinese medicine composition of the present invention comprises the steps:

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 50～90 ℃ with 3～8 times of water gagings, and each 1～3 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50～70 ℃; Medicinal residues after the extraction extract 2～3 times at 40～80 ℃ with 3～8 times of amount ethanol of 40～70%, and each 1～3 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50～70 ℃;

C. qinghuo reagent I, clear paste II, cyclodextrin clathrate, mix homogeneously is made active component of the present invention.

The preparation method of best Chinese medicine composition of the present invention comprises the steps:

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;

Preparation method three:

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 1～10 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;

Adding ethanol to clear paste I makes and contains alcohol amount and reach 50～80%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, thin up to density is 1.01～1.15, rotating speed with 5000～20000 rev/mins is centrifugal, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 1～5 times of column volume 1～3 time, 20%～80% ethanol elution of 2～8 times of column volumes of reuse 1～3 time, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;

Add water to clear paste II that to be diluted to density be 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2～10 times distilled water eluting of first usefulness column volume 1～3 time, and water liquid discards, reuse 50～80% ethanol elutions 1～3 time, eluting ethanol is 2～10 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;

C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II mixes with cyclodextrin clathrate, makes active component of the present invention.

B. active component preparation:

Adding ethanol to clear paste I makes and contains alcohol amount and reach 60～70%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, thin up to density is 1.02～1.10, rotating speed with 10000～15000 rev/mins is centrifugal, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 2～4 times of column volumes 2～3 times, 40～70% ethanol elution of 3～6 times of column volumes of reuse 2～3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;

Add water to clear paste II that to be diluted to density be 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2～8 times distilled water eluting of first usefulness column volume 2～3 times, and water liquid discards, reuse 60～70% ethanol elutions 2～3 times, eluting ethanol is 2～8 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;

B. active component preparation:

Add ethanol to clear paste I and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;

Add water to clear paste II that to be diluted to density be 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;

Among the present invention, its active component is among one among clear paste I, dry extract I, clear paste II, the dry extract II or combination in any, makes with the cyclodextrin clathrate mix homogeneously.

The preparation method of Chinese medicine composition of the present invention is active component and the conventional adjuvant mix homogeneously of tablet that will make, according to the conventional preparation method preparation of tablet, promptly

The preparation method of preferred tablet of the present invention is active component and the crospovidone that will make, and mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

The preparation method of best tablet of the present invention is active component and the crospovidone that will make, and mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, sheet weighs 0.45, promptly gets tablet.

Chinese medicine composition preparation method of the present invention can adopt present common extracting method to prepare active component, then active component and appropriate amount of auxiliary materials is prepared into tablet.

Process for preparing medicine four of the present invention:

A. the hook taking rattan is 15.50～55.80 parts, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 1～4 time, and each 0.2～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 1～4 time, and each 0.2～3 hour, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 30～65%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 1～4 time, and each 0.2～1.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 1～4 time, and each 0.2～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1～4 time with 50～85% alcohol heating reflux respectively, and each 0.5～3.5 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 1～4 time with 50～85% alcohol heating reflux, and each 0.5～3.5 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 6～14% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 50～95 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;

C. get above-mentioned dry extract and additive of tablet commonly used at present, make tablet according to present conventional tablet preparation method.

Preferred process for preparing medicine of the present invention comprises the steps:

A. the hook taking rattan is 27.17～41.20 parts, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2～3 times, and each 0.5～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 2～3 times, and each 0.5～2 hour, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 35～55%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 2～3 times, and each 0.2～1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 2～3 times, and each 0.5～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2～3 times with 60～80% alcohol heating reflux respectively, and each 1～3 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 2～3 times with 60～80% alcohol heating reflux, and each 1～3 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 8～12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 60～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;

C. get above-mentioned dry extract, add a kind of of cane sugar powder, dextrin, soluble starch or PVP or their combination, mixing is granulated, and makes tablet according to the sheet agent method.

Best process for preparing medicine of the present invention comprises the steps:

A. 34.10 parts in hook taking rattan, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss are standby;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water secondary, and each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;

C. get above-mentioned dry extract, add a kind of of cane sugar powder, dextrin, soluble starch or PVP or their combination, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.45g, coating or bag film-coat promptly do not get tablet.

Preparation method five

Process for preparing medicine five of the present invention comprises the steps

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 1～4 time, and each 0.5～3 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 30～60%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 1～4 time, and each 0.5～3.5 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 30～50%, standing over night, filter, reclaim ethanol and be concentrated into certain volume, standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 1～4 time, each 0.2～2 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 20～60%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 1～4 time, each 0.2～3.5 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40～80%, standing over night, filter, reclaim ethanol, be concentrated into an amount of, standby;

C. said extracted liquid is mixed, drying adds volatile oil, gets dry extract; Get above-mentioned dry extract and additive of tablet commonly used at present, make tablet according to present conventional tablet preparation method.

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 2～3 times, and each 1～2 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 40～50%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 2～3 times, and each 1～3 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 35～45%, standing over night, filter, reclaim ethanol and be concentrated into certain volume, standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 2～3 times, each 0.5～1.5 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 30～50%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 2～3 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, added ethanol and made and contain the alcohol amount and reach 50～70%, and standing over night filters, and reclaims ethanol, is concentrated in right amount, and is standby;

C. said extracted liquid is mixed, drying adds volatile oil, gets dry extract; Get above-mentioned dry extract, add a kind of of cane sugar powder, dextrin, soluble starch or PVP or their combination, mixing is granulated, and makes tablet according to the sheet agent method.

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water secondary, and each 1.5 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 45%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain alcohol and measure and reach 40%, standing over night filters, and reclaims ethanol and is concentrated into certain volume, and is standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water secondary, each 1 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 45%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain alcohol and measure and reach 60%, standing over night, filter, reclaim ethanol, be concentrated into an amount of, standby;

More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.

The specific embodiment

In order to understand the present invention better, logical below test example is further set forth the beneficial effect of medicine of the present invention.These test examples comprise the clinical efficacy experimental observation of medicine of the present invention.By observing medicine of the present invention wind and cold is held under the arm wet hold under the arm the stagnate flu of card, the influence of acute gastroenteritis, the therapeutical effect of medicine of the present invention is described.Below used medicine of the present invention for the ease of narration, below will be called for short medicine of the present invention according to the medicine of embodiment 12 methods preparation according to the preparation of embodiment 12 methods in the test.

Medicine main pharmacodynamics research data of the present invention

One of pharmacodynamic study: medicine of the present invention is to the influence of mice gastric emptying, intestinal propulsion

1 experiment material

1.1 medicine and reagent

1.1.1 medicine of the present invention: dry medicated powder (not containing excipient), the suitable crude drug amount of every gram 4.1g is provided lot number 20030212 by Wanglaoji Pharmaceutical Co., Ltd., Guangzhou City.Mice little, in, heavy dose of 10 times, 20 times, 30 times designs by clinical adult (60kg) consumption per day (0.185g/kg), be equivalent to crude drug amount: 1.85g/kg, 3.70g/kg, 5.55g/kg respectively.Medicine is made into 92.5g/L, 185g/L, 277.5g/L with distilled water, and the administration volume is 20mL/kg, adopts gastric infusion.

1.1.2 BAOJIWAN: dry medicated powder (not containing excipient) is provided lot number: 20030212 by Yangcheng Medicine Co., Ltd., Guangzhou City.The dosage of mice is by 10 times, 20 times designs of clinical adult (60kg) consumption per day (0.185g/kg), and dosage is: 1.85g/kg, 3.70g/kg.Medicine is made into 92.5g/L, 185g/L with distilled water, and the administration volume is 20mL/kg, adopts gastric infusion.

1.1.3 fourth woods: tablet, every 10mg, Xian-Janssen Pharmaceutical Ltd. produces, lot number: 990825009.Proportionately 10 times of designs of people's consumption of the dosage of mice are 5mg/kg, and medicine is made into 0.25mg/ml with distilled water, adopt gastric infusion.

1.1.4 cisapride: tablet, every 5mg, Xian-Janssen Pharmaceutical Ltd. produces, lot number: 991021107.Proportionately 10 times of designs of people's consumption of the dosage of mice are 2.5mg/kg, and medicine is made into 0.125mg/mL with distilled water, adopt gastric infusion.

1.1.5 dopamine hydrochloride inj: 20mg/2mL, Jintan City, Jiangsu Province pharmaceutical factory produces, lot number: 0202221, the dosage that mice is adopted is 5mg/kg, and medicine is 0.5mg/mL with the normal saline dilution, and the administration volume is 10ml/kg, adopts intraperitoneal injection.

1.1.6 adrenalin hydrochloride injection: every milliliter contains lmg, Mingxing Pharmaceutical Factory, Guangzhou production, and lot number: 021102, the mice dosage is 0.5mg/kg, and being diluted to concentration with normal saline is 0.05mg/mL, and hypodermic volume is the 0.1mg/10g body weight.

1.1.7 atropine sulfate injection: every milliliter contains 0.5mg, and people pharmaceutical Co. Ltd of Guangdong nation produces, lot number: 020303, the dosage of mice is 0.5mL/kg, be diluted to 0.05mg/mL with normal saline, volume injected is the 0.1mL/10g body weight, adopts subcutaneous injection.

1.1.8 the neostigmine methylsulfate injection: 2mL contains 1mg, Shanghai Xinyi Pharmaceutical Plant produces, lot number: 021003, and the dosage of mice is 0.12mg/kg, is diluted to 0.012mg/mL with normal saline, volume injected is the 0.1mL/10g body weight, adopts subcutaneous injection.

1.1.9 the metoclopramide sheet, every 5mg, Jiangsu Pengyao Pharmaceutical Co., Ltd. produces, lot number: 010618, mice dosage is 10mg/kg, medicine is made into 0.5mg/mL with distilled water, adopts gastric infusion.

1.2 animal: the NIH mice, 18～23g, the cleaning level is provided the quality certification: 2002A028 by Traditional Chinese Medicine University Of Guangzhou's Experimental Animal Center.

2 experimental techniques and result

2.1 medicine of the present invention is to the influence of normal mouse gastric emptying ^[1]

Get above-mentioned specification mice, random packet, that is: distilled water group, medicine of the present invention little, in, heavy dose of group, little, the middle dosage group of Health pill, cisapride group.Except that the cisapride group, the administration treated animal was by above-mentioned dosage administration in advance 3 days, and every day 1 time, the distilled water group is given the equal-volume distilled water.Fasting is 16 hours before the last administration, after the administration 1 hour, behind the cisapride single administration 0.5 hour, quantitatively irritates stomach nutrition and sticks with paste and (press document ^[1]Method prepares in advance), every 0.6ml, animal is put to death in dislocation after 20 minutes, cuts open the belly to pluck stomach and claim the stomach gross weight with electronic balance, claims the stomach net weight after removing gastric content, deducts the stomach net weight with the stomach gross weight, i.e. and residual quantity is stuck with paste in stomach nutrition.Adopt the t check to compare the statistical significance of administration group and distilled water group.

The results are shown in Table 1, data show in the table, and medicine of the present invention and Health pill are to the effect of normal mouse gastric emptying all not obvious (P＞0.05), and cisapride then has obvious minimizing stomach rice to stick with paste the effect (P＜0.05) of residual quantity.

Table 1, medicine of the present invention are to the influence of normal mouse gastric emptying

Compare with the distilled water group: ^*P＜0.05

2.2 medicine of the present invention causes the influence of mice delayed gastric emptying to dopamine hydrochloride ^[2]

Get above-mentioned specification mice, random packet, that is: distilled water group, distilled water+dopamine group, little, the middle and high dosage group of medicine of the present invention+dopamine group, little, the middle dosage of Health pill+dopamine group, motilium+dopamine group.Except that the motilium group, the administration treated animal was by above-mentioned dosage administration in advance 3 days, and every day 1 time, distilled water group and distilled water+dopamine group is given the equal-volume distilled water.Fasting is 16 hours before the last administration, and after the administration 1 hour, behind the motilium single administration 0.5 hour, except that the distilled water group, all the other respectively organized equal lumbar injection dopamine, and the distilled water group is then injected the equal-volume normal saline.Quantitatively irritate stomach nutrition after 10 minutes and stick with paste (preparing in advance) by literature method, every 0.6ml, animal is put to death in dislocation after 20 minutes, cut open the belly and pluck stomach and claim the stomach gross weight with electronic balance, claim the stomach net weight after removing gastric content, deduct the stomach net weight with the stomach gross weight, i.e. residual quantity is stuck with paste in stomach nutrition.Adopt the t check to compare the statistical significance of administration group and dopamine group.

The results are shown in Table 2, data show in the table, and residual quantity is stuck with paste in nutrition in distilled water+dopamine group stomach obviously increases (P＜0.01) than the distilled water group, and the prompting dopamine significantly postpones the mice gastric emptying.Medicine low dose of the present invention, dosage group and distilled water in the medicine of the present invention+dopamine group compares, and its stomach nutrition is stuck with paste residual quantity and is obviously reduced (P＜0.01), and pointing out two kinds of dosage medicines of the present invention that dopamine is caused the mice delayed gastric emptying has antagonism.Health pill low dose and motilium show similar effect (P＜0.05 or P＜0.01), but medicine of the present invention and Health pill effect of high dosage are not obvious.

Table 2, medicine of the present invention cause the influence of mice mice delayed gastric emptying to dopamine hydrochloride

Compare with the distilled water group: ^##P＜0.01; Compare with distilled water+dopamine group: ^*P＜0.05, ^*P＜0.01

2.3 medicine of the present invention is to the propulsive influence of small intestine movement of mice

Get above-mentioned specification mice and be divided into 6 groups at random: three dosage groups of medicine of the present invention, two dosage groups of Health pill, metoclopramide group and distilled water matched group, the administration treated animal is by above-mentioned dosage administration in advance 3 days, every day 1 time.Matched group is given the equal-volume distilled water.Fasting is 12 hours before the last administration, 1 hour every animal is irritated suspension (5% charcoal end, stomach charcoal end after the administration, 10% gelatin) 0.2mL, put to death in 20 minutes, take out small intestinal and be tiled on the blank sheet of paper, measure the propulsive length in small intestinal total length and charcoal end, with both percentage ratio as advancing percentage rate, relatively each administration group and matched group significant difference adopt the t check.

The results are shown in Table 3, data show in the table, three dosage of medicine of the present invention, and only low dose has the intestinal propulsion effect (P＜0.05) of acceleration, and two dosage of middle and high dosage and medicine of the present invention are to the propulsive influence of mouse small intestine not obvious (P＞0.05).

Table 3, medicine of the present invention are to the influence of small intestine movement of mice progradation

Compare with the distilled water matched group: ^*P＜0.05, ^*P＜0.01

2.4 medicine of the present invention advances hyperfunction influence to neostigmine load mouse small intestine ^[3]

Get above-mentioned mice, be divided into 7 groups at random: distilled water matched group, neostigmine model group, three dosage of medicine of the present invention+neostigmine group, two dosage of Health pill+neostigmine group.Administration treated animal administration in advance 3 days, every day 1 time, fasting is 12 hours before the last administration, after the administration 1 hour, model group animal and administration treated animal subcutaneous injection neostigmine (0.12mg/kg), model group and matched group subcutaneous injection equal-volume normal saline, and irritate stomach charcoal end suspension immediately, 20 minutes execution animals, measure the intestinal propulsion percentage rate by last method, adopt the t check, difference comparison model group and matched group, the statistical significance of each administration group and model group.

The results are shown in Table 4, data show in the table, the apparent in view raising of model group intestinal propulsion percentage rate and matched group (P＜0.01), and it is hyperfunction that the prompting neostigmine can cause that mouse small intestine advances.The middle and high dosage of medicine of the present invention and two dosage groups of Health pill intestinal propulsion percentage rate obviously reduce than model group, and the intestinal propulsion of pointing out medicine of the present invention, Health pill that neostigmine is caused is hyperfunction inhibitory action.

Table 4, medicine of the present invention cause mouse small intestine to neostigmine and advance hyperfunction influence

Compare with the distilled water matched group: ^##P＜0.01; Compare with model group: ^*P＜0.05

2.5 medicine of the present invention is to the propulsive influence of atropine load mouse small intestine ^[3]

Get above-mentioned specification mice and be divided into 7 groups at random: distilled water matched group, model group, three dosage of medicine of the present invention+atropine group, two dosage of Health pill+atropine group, metoclopramide+atropine group.Administration treated animal administration in advance 3 days, every day 1 time, model group and matched group are given the equal-volume distilled water, fasting is 12 hours before the last administration, after the administration 1 hour, model group and administration treated animal subcutaneous injection atropine (0.5mg/kg), matched group injection equal-volume normal saline.And irritate stomach charcoal end suspension immediately, put to death animal, and measured the intestinal propulsion percentage rate in 20 minutes by last method.Adopt the t check, comparison model group and distilled water matched group, the significant difference of administration group and model group.

The results are shown in Table 5, data show in the table, and model group intestinal propulsion percentage rate obviously reduces (P＜0.01) than matched group, and the prompting atropine can cause the inhibition of intestinal propulsion.Medicine high dose of the present invention and the apparent in view rising of model group (P＜0.05), two dosage of all the other low doses and Health pill and model group be no significant difference (P＞0.05) relatively all.

Table 5, medicine of the present invention cause mouse small intestine to atropine and advance the influence that suppresses

Compare with the distilled water matched group: ^##P＜0.01; Compare with model group: ^*P＜0.05, ^*P＜0.01

2.6 medicine of the present invention is to the propulsive influence of epinephrine load mouse small intestine ^[3]

Get above-mentioned specification mice and be divided into 7 groups at random: distilled water matched group, model group, three dosage of medicine of the present invention+epinephrine group, two dosage of Health pill+epinephrine group, metoclopramide+epinephrine group.Administration treated animal administration in advance 3 days, every day 1 time, model group and matched group are given the equal-volume distilled water, fasting is 12 hours before the last administration, after the administration 1 hour, model group and administration treated animal subcutaneous injection epinephrine (0.5mg/kg), matched group injection equal-volume normal saline.And irritate stomach charcoal end suspension immediately, put to death animal, and measured the intestinal propulsion percentage rate in 20 minutes by last method.Adopt the t check, comparison model group and distilled water matched group, the significant difference of administration group and model group.

The results are shown in Table 6, data show in the table, and model group intestinal propulsion percentage rate significantly descends (P＜0.01) than matched group, and the prompting epinephrine can make intestinal propulsion obviously suppress.Three dosage groups of medicine of the present invention advance percentage rate and the apparent in view raising of model group (P＜0.05 or P＜0.01), carry this and show that said preparation causes mouse small intestine to epinephrine and advances inhibition that antagonism is arranged.Two dosage effects of Health pill not obvious (P＞0.05).

Table 6, medicine of the present invention cause mouse small intestine to epinephrine and advance the influence that suppresses

Compare with the distilled water matched group: ^##P＜0.01; Compare with model group: ^*P＜0.05; ^*P＜0.01

List of references

1. the Wu Chun good fortune is old many. the discussion of mice gastric emptying model, Chinese Pharmacological circular, 1997; 13 (3): 271

2. Wang Jing, Hou Jiayu. power stomach granule is to the influence of digestive tract power, and world Chinese digests magazine, and 2000; 8 (4): 377

3. your person of outstanding talent of king, Du Qun, Shao Tingyin, etc. the just mechanism research of relieving constipation square tube, Traditional Chinese Medicine University Of Guangzhou's journal, 1999; 16 (2): 145

Two of pharmacodynamic study: medicine antidiarrheal of the present invention, analgesia and spasmolysis test

1 material

1.1 medicine and reagent

1.1.2 BAOJIWAN: dry medicated powder (not containing excipient), provide by Yangcheng Medicine Co., Ltd., Guangzhou City, lot number: 20030212, the dosage of mice is by 10 times, 20 times designs of clinical adult (60kg) consumption per day (0.185g/kg), and dosage is: 1.85g/kg, 3.70g/kg.Medicine is made into 92.5g/L, 185g/L with distilled water, and the administration volume is 20mL/kg, adopts gastric infusion.

1.1.3 ZHENGLUOWAN: 150mg/ grain, Japan Taiko Pharmaceutical Co., Ltd. maker is produced, lot number: 11VA07, build date: 01/2000, Coming-of-Age Day consumption be 22.5mg/kg, the dosage of mice by Coming-of-Age Day consumption 10 times of designs, be 225mg/kg, medicine is made into 11.25mg/mL with distilled water, and the administration volume is 20mL/kg, adopts gastric infusion.

1.1.4 acecoline: analytical pure, Military Medical Science Institute medical supply station, lot number: 20020908.

1.1.5 histamine phosphate: biochemical reagents, Shanghai Inst. of Biochemistry, Chinese Academy of Sciences produces, lot number: 200210291.

1.2 animal: the NIH mice, 18～22g, the cleaning level is provided the quality certification: 2002A028 by Traditional Chinese Medicine University Of Guangzhou's Experimental Animal Center; New Zealand white rabbit, 2.0～2.5kg, Baiyun District plant provides the quality certification by Guangzhou fringe north: 2002A010; Albino guinea-pig, body weight 250～350g is provided the quality certification: 2002A062 by No.1 Military Medical Univ.'s Experimental Animal Center.

2 experimental techniques and result

2.1 medicine of the present invention causes the anti-diarrhea effect of diarrhea of mouse model to Folium Sennae ^[1]

Get above-mentioned specification mice and be divided into 7 groups at random: distilled water matched group, the large, medium and small dosage group of medicine of the present invention, in the Health pill, small dose group, the ZHENGLUOWAN group, administration treated animal administration in advance 3 days, every day 1 time, matched group is given the equal-volume distilled water, and fasting is 6 hours before the last administration.After the administration 1 hour, every animal is irritated stomach 70% Folium Sennae water extract 0.4mL, mice is placed on 1 * 1cm screen cloth, on diameter 10cm filler cap, filter paper on the pad off the net, observed 1 time in per 2 hours, counting rushes down the down number of times of feces, rush down down feces and comprise that unshaped is mashed just and loose stool, with 6 hours accumulative total cathartic number of times as evaluation index, relatively the difference of administration group and water matched group adopts the t check analysis.

The results are shown in Table 1, the data in the table show that three dosage groups of medicine of the present invention, the discharge in 6 hours of two dosage treated animals of Health pill are rushed down following number of times just and obviously reduced (P＜0.05 or P＜0.01) than the distilled water matched group.In the medicine of the present invention, second of low dose group and Health pill small dose group 2 hours and the 3rd discharged and rush down down just that number of times also obviously reduces than matched group in 2 hours.Point out medicine of the present invention that anti-diarrhea effect is arranged.

Table 1, medicine of the present invention cause the anti-diarrhea effect (x ± s) of diarrhea of mouse model to Folium Sennae

Compare with matched group: ^*P＜0.05; ^*P＜0.01

2.2 the analgesic activity of medicine of the present invention test

2.2.1 acetic acid twisting method ^[2]: get above-mentioned specification mice fasting 12 hours, stratified random grouping and administration are the same, after the administration 1 hour, after the rotundine administration 30 minutes, lumbar injection 0.6% acetic acid 0.1mL/10g body weight, count 20 minutes mouse writhing number of times and writhing response and incubation period occurs, adopt the t check statistical significance of each administration group and matched group relatively respectively.

The results are shown in Table 2, data show in the table, and each administration group and matched group compare, difference that the incubation period of writhing response, there are no significant (P＜0＞0.05); Turn round body number of times medicine high dose group of the present invention and obviously reduce (P＜0.05) than matched group, two dosage groups of Health pill also have certain minimizing, but there was no significant difference (P＞0.05).Point out medicine of the present invention that certain analgesic activity is arranged.

The analgesic activity of table 2, medicine Dichlorodiphenyl Acetate writhing method mice of the present invention (x ± s)

Compare with the distilled water matched group: ^*P＜0.05; ^*P＜0.01

2.3 the spasmolysis of medicine of the present invention test ^[3]

Get healthy new zealand rabbit (or Cavia porcellus), the mallet portion of tapping the head causes death, and takes out rabbit ileum and guinea pig ileum immediately and places tyrode's solution, wash out the enteric cavity content with tyrode's solution, get the intestinal tube that is about 2.0cm, hang in the maxwell bath pipe that fills the 20mL tyrode's solution, 37 ± 0.5 ℃ of constant temperature, bubbling air.Trace curve movement with WXT～dynamic balancing monitor, treat to add behind the intestinal tube motion stabilization being subjected to the reagent thing, the variation of record administration anterioposterior curve, and calculate the antagonism percentage rate.Observe medicine of the present invention, the antagonism the when supernatant in the Health pill aqueous solution causes that to acetylcholine tetanic property contraction of rabbit ileum and histamine cause the contraction of the tetanic property of guinea pig in vitro small intestinal of various dose respectively.

The result shows: the rabbit that medicine of the present invention causes the acetylcholine tetanic property of the ileum contraction of exsomatizing has certain antagonism, but action intensity a little less than, the Health pill effect is not obvious.Medicine of the present invention causes that to histamine the spastic contraction of guinea pig ileum has significant antagonism (table 3).

The exsomatize effect of the spastic contraction of guinea pig ileum that ileum tetanic property contraction and histamine cause of the rabbit that table 3, medicine of the present invention cause acetylcholine

Annotate: in the bracket is the intestinal segment number

3. brief summary

3.1 the test of mouse anti diarrhoea shows: three dosage of medicine of the present invention and two dosage of Health pill cause the diarrhea of mouse model to Folium Sennae obvious diarrhea effect, show as administration group 6 hours accumulative total and rush down down just number of times, in the medicine wherein of the present invention, low dose of (3.70g/kg, 1.85g/kg) and Health pill low dose (1.85g/kg) after giving the agent of Folium Sennae diarrhea inducing second 2 hours and the 3rd rushed down down just in 2 hours that number of times also obviously reduces (P＜0.05 or P＜0.01) than matched group than the obvious minimizing of matched group (P＜0.05 or P＜0.01).

3.2 the test of acetic acid twisting method shows, each dosage group of medicine of the present invention and Health pill and matched group are relatively, the equal no significant difference incubation period of writhing response (P＞0.05), medicine high dose of the present invention (5.55g/kg) group is turned round the body number of times and is obviously reduced (P＜0.05) than matched group, two dosage groups of Health pill also have certain minimizing, but difference not significantly (P＞0.05).Above results suggest medicine of the present invention and Health pill have certain analgesic activity, but onset is slow and effect a little less than.

3.3 isolated rabbit small intestinal and the test of stripped small intestine of guinea pig spasmolysis show that medicine doses of the present invention causes that to acecoline the spastic contraction of isolated rabbit ileum has certain antagonism.The spastic contraction of guinea pig ileum that histamine phosphate is caused has tangible antagonism, thinks that mainly the tonicity of dosing metagaster obviously descends, and points out medicine of the present invention that certain spasmolysis is arranged.The Health pill spasmolysis of same dose is not obvious.

List of references:

1. open bright, etc. Pericarpium Zanthoxyli antalgic and warming middle-JIAO to stop diarrhea pharmacological research, Chinese crude drug, 1994; 17 (2): 37

2. Qi Chen edits. herbal pharmacology research methodology, Beijing: People's Health Publisher, 1993 (front pages): 377～378

3. Xu Shuyun edits. pharmacological experimental methodology, Beijing: People's Health Publisher, 1982 (front pages): 865

Three of pharmacodynamic study: medicine Chinese People's Anti-Japanese Military and Political College's Mus acute gastric mucosal lesion of the present invention and to the influence of rat tolerance secretion

1 experiment material

1.1 medicine and main agents

1.1.1 drug powder of the present invention: do not contain excipient, the suitable crude drug amount of every gram 4.1g is provided lot number: 20030212 by Wanglaoji Pharmaceutical Co., Ltd., Guangzhou City.The dosage of rat is respectively 0.925g/kg, 1.85g/kg, 3.70g/kg by 5 times, 10 times, 20 times designs of clinical adult's consumption, and medicine is made into 92.5g/L, 185g/L, 370g/L with distilled water, and the administration volume is 10mL/kg, adopts gastric infusion.

1.1.2 BAOJIWAN: dry medicated powder (not containing excipient) is provided lot number: 20030212 by Yangcheng Medicine Co., Ltd., Guangzhou City.The dosage of mice is by 10 times of designs of clinical adult (60kg) consumption per day (0.185g/kg), and dosage is: 1.85g/kg.Medicine is made into 92.5g/L with distilled water, and the administration volume is 20mL/kg, adopts gastric infusion.

1.1.3 Selbex capsules: contain teprenone 50mg in one, make by Japanese Eisai Co., Ltd, defend material (China) company limited packing, lot number: 020581, lot number of the repackaged products: 020581A, adult consumption 150mg every day is equivalent to 2.5mg/kg, and rat dosage is by the 10 times designs of Coming-of-Age Day with dosage, be equivalent to 25mg/kg, medicine is made into 2.5g/L with distilled water, and the administration volume is the 10mL/kg body weight, adopts gastric infusion.

1.1.4 histamine phosphate: biochemical reagents, Shanghai Inst. of Biochemistry, Chinese Academy of Sciences produces, lot number: 200210291.The rat consumption is 4 μ g/kg, adopts drug administration by injection on the skin.

1.2 animal: the SD rat, 195～240g, the cleaning level, the male and female dual-purpose is provided by Guangdong Medical Lab Animal Center, the quality certification: 2002A024.

2 experimental techniques and result

2.1 medicine of the present invention Chinese People's Anti-Japanese Military and Political College Mus acute gastric mucosal lesion effect ^[1]

Get above-mentioned specification rat, be divided into 6 groups at random: the distilled water matched group, medicine of the present invention is little, in, heavy dose of group, Health pill group, histamine phosphate's group.The administration treated animal was by above-mentioned dosage administration in advance 3 days, every day 1 time, matched group is given the equal-volume distilled water, fasting is 24 hours before the last administration, after the administration 1 hour, every rat oral gavage ethanol solution hydrochloride (100mL solution contains dehydrated alcohol 60mL, HCl 15mmol) 0.7mL put to death animal after 1 hour, get stomach ligation pylorus and cardia, inject 1% formalin 10mL to gastric, stomach is dipped in in the concentration formalin 10 minutes, cut off along greater gastric curvature, be tiled on the blank sheet of paper, perusal gastric mucosa injury situation as damage index, is damaged incidence rate with the number of animals that damage takes place and the percentage calculation of animal sum with the total length (mm) of streak damage.The significant difference that compares administration group and matched group.

The results are shown in Table 1, data show in the table, and medicine of the present invention and Health pill group gastric mucosa injury index all obviously reduce than the distilled water group, and pointing out medicine of the present invention and Health pill that acidic alcohol is caused the gastric mucosa of rat acute injury has significant protective effect.

Table 1, medicine of the present invention are to the effect of rat acute gastric mucosa injury

Compare with the distilled water group: ^*P＜0.05; ^*P＜0.01

2.2 medicine of the present invention is to the influence of rat tolerance secretion ^[2]

Get above-mentioned specification rat stratified random and be divided into 6 groups: the distilled water group, medicine of the present invention is little, in, heavy dose of group, Health pill group, histamine phosphate's group.Chinese drug-treated group administration in advance 3 days, administration every day 1 time, last adopts duodenal administration.Matched group is given the equal-volume distilled water, and histamine phosphate's group adopts disposable administration.Before the last administration, animal fasting 24 hours.Etherization, routine disinfection, laparotomy ventrotomy ligation pylorus is subjected to the reagent thing from the duodenum injection, and matched group injects distilled water group, histamine phosphate's group subcutaneous injection histamine phosphate.Sew up wound, send back in the cage, put to death animal after 5 hours, collect gastric juice, with 2000rpm centrifugal 10 minutes, measure gastric juice amount (mL), get supernatant 2mL, add and start going to a nursery not and phenolphthalein indicator,, and calculate total acid output (total acidity * per hour gastric juice amount) with 0.02N NaOH titration free acid and total acidity.Adopt the t check to compare the statistical significance of each administration group and matched group.

The results are shown in Table 2, the data in the table show that medicine low dose of the present invention does not have tangible influence to rat stomach liquid measure, free acid, total acidity, total acid output, and heavy dose of gastric juice amount, total acid output then obviously reduce, and point out the inhibitory action of this dosage to stomachial secretion.The Health pill effect is not obvious.

Table 2, medicine of the present invention are to the excretory influence of rat stomach

Compare with the distilled water group: ^*P＜0.05; ^*P＜0.01

3 brief summaries

3.1 Chinese People's Anti-Japanese Military and Political College's Mus acute gastric mucosal lesion test shows that three dosage of medicine of the present invention (0.925g/kg, 1.85g/kg, 3.70g/kg) and Health pill (1.85g/kg) can obviously reduce the damage index that acidic alcohol causes the rat acute gastric mucosa injury.Point out two kinds of preparations that the acute gastric mucosal lesion that some foreign substance causes is had protective effect.

3.2 gastric acid secretion test shows, in in the medicine of the present invention, low dose of (1.85g/kg, 0.925g/kg) do not have tangible influence to the pylorus ligation rat tolerance secretion, heavy dose of (3.7g/kg) shows as gastric secretion and total acid output obviously reduces than matched group, points out this dosage that stomachial secretion is had inhibitory action.Health pill (1.85g/kg) does not have tangible influence to stomachial secretion.

List of references

1. your person of outstanding talent of king, Wang Jianhua, Fu Dingzhong, etc. anti-gastric mucosa injury of BUZHONG YIQI TANG and mechanism, Pharmacology and Clinics of Chinese Materia Medica, 1993; 9 (5): 5

The Qi Chen chief editor. herbal pharmacology research methodology, People's Health Publisher, 1993:859

Further set forth the preparation method of medicine of the present invention by the following examples.

Embodiment 1:

A. get prescription one: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 6.5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 65～70 ℃ of temperature are extracted each 2.5 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 9 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 700 order Fructus Oryzae Germinatus superfine powder, standby;

C. get above-mentioned dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder, crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 2:

A. get prescription two: Ramulus Uncariae Cum Uncis 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, the Radix Aucklandiae 21 5.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 50～60 ℃ of temperature are extracted each 3 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 7 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, standby;

C. get above-mentioned dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder, crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.45g, the bag film-coat promptly gets tablet.

Embodiment 3:

A. get prescription three: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 95.20g are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 85～90 ℃ of temperature are extracted each 2 hours 3 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 3 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 900 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 4:

A. get prescription four: Ramulus Uncariae Cum Uncis 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3.5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 25 ℃ of temperature are extracted 2 times, extract 1 hour; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 5 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 800 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 5:

A. get prescription five: Ramulus Uncariae Cum Uncis 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Guangdong Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 45～55 ℃ of temperature are extracted each 1 hour 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 5 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 650 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 6

A. get prescription six: Ramulus Uncariae Cum Uncis 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5.5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 35～45 ℃ of temperature are extracted each 2.5 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 4.5 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 400～500 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 7

A. get prescription seven, Ramulus Uncariae Cum Uncis 35g, Cortex Magnoliae Officinalis 230g, Radix Trichosanthis 95g, Poria 250g, Radix Angelicae Dahuricae 130g, Guangdong Massa Medicata Fermentata 130g, Fructus Tribuli 35g, Rhizoma Atractylodis 135g, Radix Puerariae 140g, Exocarpium Citri Grandis 75g, Fructus Oryzae Germinatus 100g, Flos Chrysanthemi 75g, Radix Aucklandiae 140g, wide leaves of pulse plants 140g, Herba Menthae 75g, Semen Coicis 180g;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2.5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 63 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 7.5 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, standby;

Embodiment 8

A. get prescription, it is standby with embodiment 2 to write out a prescription;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 48 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 7 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 9

A. get prescription, it is standby with embodiment 3 to write out a prescription;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 8 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 75 ℃ of temperature are extracted each 1 hour 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 1000 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 10

A. get prescription, it is standby with embodiment 4 to write out a prescription;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 90 ℃ of temperature are extracted each 0.5 hour 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 3 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 11

A. get prescription, it is standby with embodiment 5 to write out a prescription;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 80 ℃ of temperature are extracted 2 times, extract 2 hours for the first time, extract 0.5 hour for the second time; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, standby;

Embodiment 12

A. get prescription, it is standby with embodiment 7 to write out a prescription;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2.5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 35 ℃ of temperature are extracted each 1.5 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 600 order Fructus Oryzae Germinatus superfine powder, standby;

C. get above-mentioned dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder, crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.45g, coating or bag film-coat promptly do not get tablet.

Embodiment 13

A. get prescription, it is standby with embodiment 6 to write out a prescription;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 60 ℃ of temperature are extracted each 1.5 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 600 order Fructus Oryzae Germinatus superfine powder, standby;

C. get above-mentioned dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder, crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.45g, promptly gets tablet.

Embodiment 14

A. get prescription, it is standby with embodiment 1 to write out a prescription;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3.5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 50 ℃ of temperature are extracted 2 times, extract 2.5 hours for the first time, extract 1.5 hours for the second time; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 3.5 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 800 orders, standby;

Embodiment 15

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 10 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 60 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, standby;

Embodiment 16

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 8 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 40 ℃ of temperature are extracted 2 times, extract 1 hour for the first time, extract 0.5 hour for the second time; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 12 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 700 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 17

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 1 times of extract amount, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 85 ℃ of temperature are extracted 2 times, extract 3 hours for the first time, extract 2 hours for the second time; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 10 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, standby;

Embodiment 18

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 10 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 90 ℃ of temperature are extracted each 1.5 hours 3 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 12 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, standby;

C. get above-mentioned dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder, crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, the bag film-coat promptly gets tablet.

Embodiment 19

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 4 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 35～40 ℃ of temperature are extracted 2 times, and 2 hours for the first time, 1 hour for the second time; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 6 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 600 order Fructus Oryzae Germinatus superfine powder, standby;

C. get above-mentioned dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder, crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, coating or bag film-coat promptly do not get tablet.

Embodiment 20

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 9 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 90 ℃ of temperature are extracted each 3 hours 3 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 12 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 800 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 21

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 1.5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 25 ℃ of temperature are extracted 1 time, extract 3 hours; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 4 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 22

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 7 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 75～80 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 10 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 600 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 23

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 35～40 ℃ of temperature are extracted each 0.5 hour 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 6 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 700 order Fructus Oryzae Germinatus superfine powder, standby;

C. get above-mentioned dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder, starch, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.45g, promptly gets tablet.

Embodiment 24

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 50～60 ℃ of temperature are extracted each 1～1.5 hour 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, standby;

Embodiment 25

A. Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, the Semen Coicis of getting embodiment 7 prescriptions are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 4 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 40～50 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 6 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 800 order Fructus Oryzae Germinatus superfine powder, standby;

C. get above-mentioned dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder, modified starch, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.45g, the bag film-coat promptly gets tablet.

Embodiment 26

A. Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, the Semen Coicis of getting embodiment 6 prescriptions are standby;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3 times of extract amounts, get cyclodextrin clathrate, standby; Medicinal residues combine, supersound extraction, and 45～55 ℃ of temperature are extracted each 1 hour 2 times; Filter, get supersound extraction liquid, standby; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 5 times of water gagings and soak, and heating decocts three times, filters, filtrate and supersound extraction liquid merge, and concentrate, and high speed centrifugation concentrates, spray drying gets dry extract, and is standby; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 400～500 order Fructus Oryzae Germinatus superfine powder, standby;

C. get above-mentioned dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder, sucrose, mixing is granulated drying, granulate; Add Polyethylene Glycol, mix homogeneously, tabletting promptly gets tablet.

Embodiment 27

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 4 times, and each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 4 times, and each 3 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 65%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 4 times, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 4 times, and each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 4 times with 85% alcohol heating reflux respectively, and each 3.5 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 4 times with 85% alcohol heating reflux, and each 3.5 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 14% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 95 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;

Embodiment 28

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 1 time, extract 0.2 hour, filter, and merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 1 time, extract 0.2 hour, filter, and merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 30%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 1 time, and inferior 0.2 hour of every extraction filters, and merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 1 time, extract 0.2 hour, filter, and merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1 time with 50% alcohol heating reflux respectively, extract 0.5 hour, filter, and merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 1 time with 50% alcohol heating reflux, and each 0.5 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 6% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 50 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;

Embodiment 29

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 3 times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate, filtrate are concentrated in right amount, add ethanol and make and contain alcohol amount and reach 30～65%, standing over night, filter, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, 3 hours per first time, and 2 hours for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 75% alcohol heating reflux respectively, and 3.5 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 75% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, filter, filtrate is concentrated into the thick paste shape with 14% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 75 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;

Embodiment 30

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 3 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, and each 2 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 55%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 80% alcohol heating reflux respectively, and each 3 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 80% alcohol heating reflux, and each 3 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;

C. get above-mentioned dry extract, add cane sugar powder, mixing is granulated, and makes tablet according to the sheet agent method.

Embodiment 31

C. get above-mentioned dry extract, add cane sugar powder, dextrin, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, every weight of plain sheet is 0.45g, coating or bag film-coat promptly do not get tablet.

Embodiment 32

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 2 times, and 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 50%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 2 times, and 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain alcohol and measure and reach 40%, standing over night filters, and reclaims ethanol and is concentrated into certain volume, and is standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 40%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain alcohol and measure and reach 60%, standing over night, filter, reclaim ethanol, be concentrated into an amount of, standby;

Embodiment 33

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 2 times, and each 1 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 45%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 2 times, and each 2.5 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 45%, and standing over night filters, and recovery ethanol also is concentrated into certain volume, and is standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 2 times, each 1.5 hours, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 40%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 2 times, each 2.5 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, added ethanol and made and contain the alcohol amount and reach 60%, and standing over night filters, and reclaims ethanol, is concentrated in right amount, and is standby;

C. said extracted liquid is mixed, drying adds volatile oil, gets dry extract; Get above-mentioned dry extract, add cane sugar powder, PVP, mixing is granulated, and makes tablet according to the sheet agent method.

Embodiment 34

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 10 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 100 ℃ with 12 times of water gagings, and each 5 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 12 times of amount ethanol of 80%, and each 5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 80 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is got the appropriate amount of starch mix homogeneously, tabletting, promptly.

Embodiment 35

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 3 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 35 ℃ with 2 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35 ℃; Medicinal residues after the extraction extract 2 times at 100 ℃ with 2 times of amount ethanol of 30%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds an amount of sweetener, starch, and mixing, tabletting are promptly.

Embodiment 36

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 6 times of water gagings, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 8 times of amount ethanol of 50%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 70 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds an amount of sucrose, starch, and tabletting, promptly.

Embodiment 37

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 90 ℃ with 8 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 70 ℃; Medicinal residues after the extraction extract 2～3 times at 80 ℃ with 8 times of amount ethanol of 70%, and each 3 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 70 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is got 2% an amount of polyvinylpyrrolidone and is mixed, and tabletting promptly.

Embodiment 38

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 50 ℃ with 3 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 3 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds crospovidone, and mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, the bag film-coat promptly gets tablet.

Embodiment 39

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 60 ℃ with 7 times of water gagings, and 2.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 4 times of amount ethanol of 60%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 60 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying is with cyclodextrin clathrate mix homogeneously, lactose, starch, with concentration 20% alcohol granulation, tabletting, promptly.

Embodiment 40

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 65 ℃ with 3 times of water gagings, and 1.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 65 ℃; Medicinal residues after the extraction extract 2 times at 59 ℃ with 4 times of amount ethanol of 65%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 65 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds an amount of dextrin, starch, is 30% alcohol granulation with concentration, tabletting, promptly.

Embodiment 41

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds an amount of sucrose, dextrin, the granulation of 2% polyvinylpyrrolidone, and tabletting is made the heavy 0.30g of plain sheet, promptly.

Embodiment 42

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 9 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 100 ℃ with 10 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 5 times of amount ethanol of 80%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 80%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.01～1.15, and is centrifugal with 20000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 5 times of column volumes 3 times, and 80% ethanol elution of 8 times of column volumes of reuse 3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 10 times distilled water eluting of first usefulness column volume 3 times, and water liquid discards, reuse 80% ethanol elution 3 times, eluting ethanol is 10 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing.

C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, make active component of the present invention, mix, with the alcohol granulation of concentration 45%, tabletting, promptly with appropriate amount of starch.

Embodiment 43

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 1 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1 time at 35 ℃ with 2 times of water gagings, extracted 5 hours, and the merge extractive liquid, filtration, relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35 ℃; Medicinal residues after the extraction extract 1 time at 100 ℃ with 2 times of amount ethanol of 30%, extract 5 hours, and merge extractive liquid, filters, extracting solution recovery ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 50%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.01～1.15, and is centrifugal with 5000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 2 times, and 20% ethanol elution of 3 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I;

C. dry extract I, clear paste II are merged, concentrate, drying adds crospovidone, and mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, the bag film-coat promptly gets tablet.

Embodiment 44

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 55 ℃ with 5.5 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 55 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 5.5 times of amount ethanol of 55%, and each 2.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃; Clear paste II adds water to and is diluted to density is 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5.5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 2 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. clear paste I, dry extract II are merged, concentrate, drying with crospovidone, mixing, is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting is made the heavy 0.45g of plain sheet, and the bag film-coat promptly gets tablet.

Embodiment 45

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 3 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 85 ℃ with 3 times of water gagings, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 75 ℃; Medicinal residues after the extraction extract 2 times at 75 ℃ with 7 times of amount ethanol of 75%, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 75 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 60%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.10, and is centrifugal with 10000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 2 times of column volumes 3 times, and 70% ethanol elution of 6 times of column volumes of reuse 3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 8 times distilled water eluting of first usefulness column volume 3 times, and water liquid discards, reuse 70% ethanol elution 3 times, eluting ethanol is 8 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of steviosin, starch is granulated with 5% starch slurry, and tabletting promptly.

Embodiment 46

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 7 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 7 times of water gagings, and each 2.5 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 70 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 4 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 70%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.10, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 40～70% ethanol elution of 5 times of column volumes of reuse 3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 60% ethanol elution 2 times, eluting ethanol is 2 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of steviosin, dextrin is granulated with 8% starch slurry, and tabletting promptly.

Embodiment 47

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 4.5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 80 ℃ with 4.5 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 7.5 times of amount ethanol of 45%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 65 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 75%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.10, and is centrifugal with 12000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 1 time, and 60% ethanol elution of 6 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 7 times distilled water eluting of first usefulness column volume 3 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 2 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

Embodiment 48

Clear paste I adds ethanol to be made and contains alcohol amount and reach 65%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting, the bag film-coat promptly gets tablet.

Embodiment 49 active component preparation methoies of the present invention

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Get part clear paste I and add ethanol and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;

Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃; Get part clear paste II and add water to that to be diluted to density be 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;

C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II with the cyclodextrin clathrate mix homogeneously, is made active component of the present invention.

Embodiment 50

B. clear paste I, the dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 49 methods are standby;

C. with clear paste I 1g, dry extract I 1g, clear paste II 1g, dry extract II 1g and cyclodextrin clathrate mix homogeneously, add crospovidone, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 51

B. clear paste I, the dry extract I, the dry extract II that get the acquisition of embodiment 49 methods are standby;

C. with clear paste I 15g, dry extract I 0.5g, dry extract II 0.5g and cyclodextrin clathrate mix homogeneously, add 50g starch, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 52

B. dry extract I, the clear paste II, the dry extract II that get the acquisition of embodiment 49 methods are standby;

C. with dry extract I 20g, clear paste II 2g, dry extract II 3g and cyclodextrin clathrate mix homogeneously, add an amount of sucrose, the 250g hydroxypropyl cellulose, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 53

C. with clear paste I 3g, dry extract I 1g, clear paste II 8g, dry extract II 1g and cyclodextrin clathrate mix homogeneously, add the 65g micropowder silica gel, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 54

B. the clear paste I, the clear paste II that get the acquisition of embodiment 49 methods are standby;

C. with clear paste I 50g, clear paste II 30g and cyclodextrin clathrate mix homogeneously, add the 100g sodium carboxymethyl cellulose, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 55

B. the dry extract I, the dry extract II that get the acquisition of embodiment 49 methods are standby;

C. with dry extract I 15g, dry extract II 7g and cyclodextrin clathrate mix homogeneously, add an amount of lactose, mixing, tabletting promptly gets tablet.

Embodiment 54

Embodiment 55

B. the dry extract I, the clear paste II that get the acquisition of embodiment 49 methods are standby;

C. with dry extract I 15g, clear paste II 7g and cyclodextrin clathrate mix homogeneously, add an amount of lactose, mixing, tabletting promptly gets tablet.

Embodiment 56

B. the clear paste I that gets the acquisition of embodiment 49 methods is standby;

C. with clear paste I 100g and cyclodextrin clathrate mix homogeneously, add the 100g sodium carboxymethyl cellulose, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 57

B. the dry extract I that gets the acquisition of embodiment 49 methods is standby;

C. with dry extract I 15g and cyclodextrin clathrate mix homogeneously, add an amount of lactose, mixing, tabletting promptly gets tablet.

Embodiment 58

B. the dry extract II that gets the acquisition of embodiment 49 methods is standby;

C. with dry extract II 4g and cyclodextrin clathrate mix homogeneously, add 30g starch, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 59

B. the clear paste II that gets the acquisition of embodiment 49 methods is standby;

C. with clear paste II 13g and cyclodextrin clathrate mix homogeneously, add an amount of sucrose, the 150g hydroxypropyl cellulose, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 60

B. the clear paste I, the dry extract I that get the acquisition of embodiment 49 methods are standby;

C. with clear paste I 15g, dry extract I 2g and cyclodextrin clathrate mix homogeneously, add the 30g dextrin, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 61

B. the clear paste II, the dry extract II that get the acquisition of embodiment 49 methods are standby;

C. with clear paste II 3g, dry extract II 25g and cyclodextrin clathrate mix homogeneously, add 240g starch, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 62

C. with clear paste I 14g, dry extract I 3g, clear paste II 5g, dry extract II 29g and cyclodextrin clathrate mix homogeneously, add 1000g starch, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Claims

1. a preparation method for the treatment of the gastrointestinal disease Chinese medicine composition is characterized in that comprising the steps:

A, to get crude drug proportioning Ramulus Uncariae Cum Uncis 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g standby;