CN101327302B - Chuan Xiong Tea soft capsule and method for preparing the same - Google Patents
Chuan Xiong Tea soft capsule and method for preparing the same Download PDFInfo
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Abstract
The invention relates to a Chuanxiong Chatiao soft capsule and a preparation method thereof. In modern medicine, the Chuanxiong Chatiao powder is improved and made into tablets, capsule, oral liquid and so on, which can not achieve the efficacy of the original formulation. The preparation method of the Chuanxiong Chatiao soft capsule is that Chuanxiong, red peony root, gastrodia elata, notopterygium, angelica, asarum, chrysanthemum, mint, parsnip, tea leaves, liquorices and catnip are put into the Chinese medicine extraction pot. Water is added for soaking, and the mixture is decocted for three times. At the same time, volatile oil is collected. The water decoction liquid and extraction liquid are combined and processed with centrifugal filtration. The filtrate is decompressed and condensed, and crushed with grain size less than 120 meshes after being processed with spray drying. The extraction volatile oil is melted with a certain amount of edible oil. Dry extractum power is mixed with edible oil. The dry extractum power takes 20-50 weight percent of the oil base in soft capsule. The mixture is grinded by a colloid mill, and pigment gelatin which is taken as capsule wall material is added and is made into capsule core extractum oil base liquid. The soft capsule is formed by pressing under the condition of stirring. The soft capsule is manufactured after being dried, washed and dried. The Chuanxiong Chatiao soft capsule is used for replacing Chuanxiong Chatiao powder.
Description
Technical field:
The present invention relates to a kind of preparation of Chinese medicinal soft capsule, is a kind of Chuan Xiong Tea soft capsule and method for preparing.
Background technology:
" Chuanxiong Chatiao San " comes from medical ancient books " formulary of peaceful benevolent dispensary ", form by Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, the Radix Angelicae Dahuricae, Herba Schizonepetae, windproof, Herba Menthae, Folium Camelliae sinensis, and for controlling the cold and heat headache that the criminal empties on the ailment said due to cold or exposure, or the side of wind syndrome of head pain.These can expelling wind and cold pathogens, light clear come-up, removing obstruction in the collateral to relieve pain; Be monarch drug altogether with Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Angelicae Dahuricae dispelling wind and relieving in the side; Wherein Rhizoma Chuanxiong is controlled few sun, JUE YIN meridian headache (amphicrania or headache), and Rhizoma Et Radix Notopterygii is controlled Taiyang channel headache (the back headache involves napex), and the Radix Angelicae Dahuricae is controlled Yangming Channel headache (preceding metopodynia); Herba Asari, Herba Menthae, Herba Schizonepetae, windproof suffering loose up, evacuate the top ailment said due to cold or exposure, strengthen the dispelling wind and relieving ability of three flavor principal agents, and double inducing sweat and be ministerial drug; During Radix Glycyrrhizae and medicine are slow and be adjuvant drug; Green tea can be gone up clearly and fall, and anti-all medicines too warm-dryness syndrome, liter loose, and makes to have in the liter and falls, and be messenger drug.Entirely can dispelling wind and relieving, cure mainly that Zhu Fengshang attacks, the head dusk weight, migraine and general headache, nasal obstruction is low voice speaking, cold high fever, limbs are tired of diseases such as pain.
Imitate definitely, be widely used through clinical verification for many years according to bibliographical information and this side's treatment of medical ancient books record; More than execute according to clinical syndrome differentiation and to control; The increase and decrease prescription; Enlarge the scope of its clinical practice, " Chuanxiong Chatiao San " adjusted difficult miscellaneous diseases such as bronchitis, sinusitis, urticaria, trigeminal neuralgia, rheumatic arthritis through prescription clinically.Mainly be to be the agent of dispelling wind pathogens according to Chuanxiong Chatiao San, can control the disease of ailment said due to cold or exposure for suffering from.Disease biasedly goes up, row does not have fixed place, rapid, the fickle characteristics of morbidity, thinks that sinusitis, trigeminal neuralgia are that wind is held the clear key of criminal on the pathogenic heat under the arm, so add the sensible article of heat clearing away such as Fructus Xanthii, Flos Magnoliae and ailment said due to cold or exposure morbidity has.Trigeminal neuralgia can add the agent of clearing away heat-fires such as Gypsum Fibrosum, Radix Gentianae, Ramulus Uncariae Cum Uncis.Rheumatic arthritis is the heresy that wind is held cold-damp under the arm, so add Radix Aconiti, Ramulus Cinnamomi, Radix Angelicae Pubescentis, Semen Coicis etc. with functions dispelling wind and clearing away cold, removing dampness.Urticaria also is due to the ailment said due to cold or exposure, thus add Bombyx Batryticatus, the Fructus Kochiae, Radix Sophorae Flavescentis etc. dispel the wind loose evil antipruritic.
Because the outstanding curative effect of " Chuanxiong Chatiao San "; Cause great attention clinical and R&D institution and enterprise widely; Take drawbacks such as inconvenience, mouthfeel be bad to original ancient prescription dosage form medicinal tea; R&D institution and enterprise develop Chinese medicine improvement dosage form in succession, like tablet, capsule, electuary, pill etc.Wherein " TONGTIAN KOUFUYE " etc. brings that " among Chinese pharmacopoeia and " national drug standards " [WS3-014 (Z-002)-2001 (Z)], based on improvement side's Chinese patent medicine extensive use in clinical of this side " ZHENGTIAN WAN ", curative effect reflects well into.
Prescription is in traditional ancient books of " Chuanxiong Chatiao San ": Rhizoma Chuanxiong, Herba Schizonepetae, destemming, and each four liang of (each 12g) Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae each two liang (each 6g), Herba Asari one or two (3g), windproof reed one two halves (4.5g) that go, Herba Menthae loses eight liang (12g) of fire.Usage is for grind to the powder altogether, and every clothes two money (6g) are eaten back green tea and transferred down the informal dress refresh oneself.Modern usage: be smalls altogether, every clothes, every day secondary, green tea is transferred time.Contain causing resuscitation with aromatic drugs medical material and volatile active component in the prescription, former technology comparison reasonable contemplation is mended benefit effect mutually mutually to the property of medicine of each component, can guarantee the effect of drug effect basically more.But present " Chuanxiong Chatiao San " that works out improves dosage form; Wherein particularly change oral liquid and capsule or dissolved granule into, with the mass efficient composition in original decoction agent, owing to concentrate and improve clarity; Increased precipitate with ethanol in the technology and caused loss of active ingredients with the filtration operation; For having causing resuscitation with aromatic drugs in the medical materials such as Fructus Forsythiae, Herba Menthae, the stearopten of function of promoting blood circulation to disperse blood clots is difficult to keep in addition, therefore directly has influence on curative effect; And the effective ingredient according to wherein institute's stripping is different, makes that " Chuanxiong Chatiao San " novel form can not reach former dosage form effect fully.
Summary of the invention:
The purpose of this invention is to provide a kind of ancient books prescription " Chuanxiong Chatiao San " is improved and be prepared into Chuan Xiong Tea soft capsule of modern Chinese medicine novel form " soft capsule " and preparation method thereof.
Above-mentioned purpose realizes through following technical scheme:
Chuan Xiong Tea soft capsule, its composition comprises: Rhizoma Chuanxiong, ratio of weight and number is: Rhizoma Chuanxiong 5-200 part, Radix Paeoniae Rubra 1-100 part; Rhizoma Gastrodiae 1-50 part, Rhizoma Et Radix Notopterygii 5-100 part, Radix Angelicae Dahuricae 5-100 part, Herba Asari 5-50 part; Flos Chrysanthemi 1-100 part, Herba Menthae 5-100 part, windproof 5-30 part, Folium Camelliae sinensis 5-100 part; Radix Glycyrrhizae 5-50 part, Herba Schizonepetae 5-100 part is processed soft capsule.
The method for preparing of described Chuan Xiong Tea soft capsule is got Chinese crude drug according to above ratio of weight and number, goes mud to clean Chinese crude drug, puts into the multi-functional Chinese medicine extraction pot, extracts centrifugal filtration; To filtrate and under 60-80 ℃, be evaporated to relative density is 1.05-1.10, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in or is emulsifiable in the edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for the 20-50% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Gelatin 0.5-5% to add brown or red opaque pigment is that the capsule material is processed capsule-core concrete oil substrate liquid, under 50-80 ℃ of stirring condition, capsule-core concrete oil substrate hydraulic pressure is processed soft capsule; Through dry, wash ball, drying makes soft capsule.
The method for preparing of described Chuan Xiong Tea soft capsule, described being extracted as: the Chinese medicine in the medicinal cupping in above-mentioned was soaked 1-2 hour, decocted three times, 1-2 hour for the first time, be respectively for the second time, for the third time 1-1.5 hour; Collect volatile oil simultaneously, merge the water decoction extracting solution.
This technical scheme has following beneficial effect:
1. should invention mainly adopt " Chuanxiong Chatiao San " prescription,, at utmost follow its former side's curative effect characteristic according to the processing technique dose of definite effective ingredient again; Adopt modern state-of-the-art Chinese medicinal soft capsule dosage form and technology,, kept the functional component of original dosage form as much as possible because production process does not relate to the clarity problem; And whole volatile oil that will extract are dissolved in oleaginous base, through the collection to volatile oil in the leaching process, and add in the soft capsule scientifically and rationally; And with the extraction extractum emulsifying of other drug, be contained within the opaque capsule material of soft capsule, make effective ingredient reasonable fully; Cover the abnormal smells from the patient of Chinese medicine, made things convenient for the patient.
2. the soft capsule of this Technology preparation is compared with oral liquid, hard capsule after former decoction agent and the improvement, not only taking convenience; Completely cut off extraneous factor such as light, wet, hot influence, quality stability is improved, guaranteed curative effect; And reduced extraction process, and reduced cost, improved economic benefit; Soft capsule dosage form is modern medicine novel form in addition, through external quality, has changed the ill-looking drawback of Chinese medicine; The quality of Chinese medicine is improved, has created possibility for Chinese medicine goes to the world.
3. this Technology " Chuan Xiong Tea soft capsule " produced is carried out pharmacology and toxicological experiment shows: be the medicine that a kind of toxicity is low, body do not had any obvious toxic-side effects.Experimentation is following:
(1) acute toxicity test:
Its mouse oral median lethal dose(LD 50) (LD
50) mensuration: get 50 of kunming mouses, body weight 18-22g/ only is divided into 5 groups, 10 every group at random.Behind the fasting 10h, use " Chuan Xiong Tea soft capsule " capsule herb liquid 1 time/day before testing, per os is irritated clothes, and each organizes dosage difference 1.000,2.150,4.620,9.940,21.370mg (crude drug amount)/kg.Observed for 1 week poisoning symptom and the death condition of record animal after the administration.Calculate LD according to the animal dead situation
50
The mensuration of 1 time on the 1st maximum tolerated dose (MTD): get 20 of kunming mouses, body weight 18-22g/ only.Can irritate the Cmax (crude drug 1g/mL) of stomach and 1 gastric infusion of maximum volume (0.05mL/g) that mice is tolerated with " Chuan Xiong Tea soft capsule " capsule herb liquid.After this observe 7d continuously, let mice ad lib and drinking-water during this
(2) subacute toxicity test test method:
60 of female Wistar rat, body weight 120-150g/ only, raise 5d in advance after, be divided into 4 groups at random, 15 every group.The I group is matched group, and II, III, IV group are the medication group.The medication group is respectively with 1/10MTD, and the dosage of 1/3MTD and MTD is irritated clothes, successive administration 60d; Matched group gives the purified water of same dose.
Detect index: observe every day, write down the mental status of animal, feed activity and defecation situation are weighed weekly 1 time.Before administration and after the off-test, in the rat tails blood sampling, whole blood is made blood routine examination, and serum is made biochemical indicator and detected.After the off-test, dissect animal, the pathological changes of internal organs is respectively organized in perusal; Take by weighing the weight in wet base of main organs (heart, liver, spleen, lungs, kidney), and calculate the organ coefficient (organ coefficient=internal organs weight in wet base/body weight * 100) of each internal organs.
Result of the test
Acute toxicity test: owing to its mouse oral median lethal dose(LD 50) is not measured, so carry out the mensuration of mice oral 1 time maximum tolerated dose on the 1st.Oral 1 time the maximum tolerated dose on the 1st of mice is 50g/kg, none animal dead in the 7d, and the mice food ration is normal, weight increase, and glossy, submissive by hair, no loose stool and other exception table are existing.The mice maximum tolerated dose is equivalent to 139 times of clinical application amount (0.36g/kg).Explain that " Chuan Xiong Tea soft capsule " is the bigger medicine of safety.
Subacute toxicity test: ordinary circumstance: duration of test activities in rats, appetite, hair color and fecaluria no abnormality seen.Through variance analysis, the growth promoter of each medication treated animal and matched group comparison no significant difference (P>0.05).Show that " Chuan Xiong Tea soft capsule " has no adverse effects to the growth promoter of rat.Each is organized rat weightening finish situation and sees table 1.
The influence that table 1 " Chuan Xiong Tea soft capsule " increases weight to rat (.X ± S)
" Chuan Xiong Tea soft capsule " to the influence of rat serum routine and serum biochemistry index, the result sees table 2 and table 3 respectively, each is organized does not relatively have significant difference between rat serum routine and the serum biochemistry index (P>0.05).Show that " Chuan Xiong Tea soft capsule " has no adverse effects to various blood cells, liver function and renal function.
Table 2 " Chuan Xiong Tea soft capsule " is to the influence of rat serum conventional index (.X ± S)
Table 3 " Chuan Xiong Tea soft capsule " is to the influence of rat blood serum biochemical indicator (.X ± S)
Table 4 " Chuan Xiong Tea soft capsule " is to the influence of Rats Organs and Tissues coefficient (X ± S)
" Chuan Xiong Tea soft capsule " to the influence of Rats Organs and Tissues coefficient, the result sees table 4, and each is organized between the Rats Organs and Tissues coefficient relatively, and difference is (P>0.05) not significantly.Show that " Chuan Xiong Tea soft capsule " is to the harmless effect of the main parenchymatous organ of rat.
The maximum tolerated dose of " Chuan Xiong Tea soft capsule " its mouse oral administration is 50g/kg.The detection explanation " Chuan Xiong Tea soft capsule " of routine blood test has no adverse effects to various hemocytees and the bone marrow hematogenesis function of rat; Detection to serum neutral and alkali phosphatase, glutamic oxaloacetic transaminase, GOT, total protein, albumin and creatinine shows that " Chuan Xiong Tea soft capsule " do not have influence to the liver function of rat; The serum urea nitrogen level is the important indicator of reflection renal function, and testing result shows that it changes in normal range, and the renal function no abnormality seen is explained renal function is had no adverse effects.Organ coefficient is that reflection is tried to the sensitivity of some organ injury degree and effectively index of thing in the toxicology, and the result shows that " Chuan Xiong Tea soft capsule " is to harmless effects of parenchymatous organ such as the heart, liver, spleen, lung and kidneys.Result of the test shows that " Chuan Xiong Tea soft capsule " toxicity is lower, can guarantee that clinical safety uses.
4. " Chuan Xiong Tea soft capsule " of this Technology production is more evident in efficacy than " Chuanxiong Chatiao San " and the increase and decrease prescription type product of existing explained hereafter.Show through the animal pharmacology pharmacodynamics test: " Chuan Xiong Tea soft capsule " can obviously improve the hemorheological biochemical indicator of rat " blood stasis " pathological model; And obviously reduce the number of times that white mice is turned round the body pain reaction; Part pharmacology index will obviously be better than " Chuanxiong Chatiao San " novel form " TONGTIAN KOUFUYE "; Show " Chuan Xiong Tea soft capsule " to because lumen of vessels stalk property and hemorheology pathological changes are said the central that causes has a headache, promptly the blood stasis headache said of the traditional Chinese medical science has the therapeutical effect of explicitly.Experimental result provides strong rationale for " Chuan Xiong Tea soft capsule " is used to have a headache clinically.Experimentation is following:
One, test material
1.1 medicine and instrument
" Chuan Xiong Tea soft capsule ": self-control (lot number: 20060202)
Tai Ji TONGTIAN KOUFUYE: Taiji Pharmaceutical Co., Ltd., Sichuan Prov.'s (lot number: 20060729)
Heparin sodium injection: Nanjing Xinbai Pharmaceutical Co's (lot number: 20060518)
Adrenalin hydrochloride injection: Tianjin gold credit aminoacid company limited (lot number: 0607211)
Nimodipine tablet: Tianbei Pharmaceutical Co., Ltd., Yunnan Prov.'s (lot number: 0607211)
Full-automatic hemorheology is learned detector: Chongqing match boat development in science and technology company limited (the full-automatic hemorheology appearance of model: SH210A)
1.2 animal
The Wistar rat, male and female half and half, body weight 250-350g: kunming mice, male and female half and half, body weight 18-22g, pharmacy head factory animal housing of Harbin medicine group provides.
Two, method and conclusion:
2.1 " Chuan Xiong Tea soft capsule " is to the influence of hemorheology of rat
2.1.1 test grouping administering mode and dosage
Intact animal's blank group: 15 rats, pure water are only irritated stomach 5ml/, tid, 7d.
" Chuan Xiong Tea soft capsule " high dose group: 15 rats, press the crude drug amount and calculate 100mg.kg-1, tid, 7d.
Dose groups in " Chuan Xiong Tea soft capsule ": 15 rats, press the crude drug amount and calculate 55mg.kg-1, tid, 7d.
" Chuan Xiong Tea soft capsule " low dose group: 15 rats, press the crude drug amount and calculate 10mg.kg-1, tid, 7d.
The pathological model group: 15 rats, pure water are only irritated stomach 5ml/, tid, 7d.
Positive control drug (nimodipine) group: 20mg.kg-1, tid, 7d.
TONGTIAN KOUFUYE group: 1ml.kg-1, tid, 7d.
2.1.2 test method and result.
Each group of test all stopped in the 7th day irritating clothes, stopped feeding.
" Chuan Xiong Tea soft capsule " high, medium and low dose groups, pathological model group, TONGTIAN KOUFUYE group, positive controls were in the 7th day subcutaneous injection adrenalin hydrochloride injection 0.08ml/100g; Per 4 hours are once, and totally twice, rat is dipped in 5min in the frozen water therebetween; Stop feeding to the second day; Each group and control rats every disconnected stem are respectively got blood, and with the beaker that is added with a small amount of heparin sodium, concussion evenly.Measure blood rheology parameter.The result sees table 5.
2.1.3 discuss
A, biochemical indicator is respectively organized in test and there is significant difference in the matched group result, and positive controls, pathological model group real result are accurate, and whole experimental science is reasonable.
B, can find out that by experimental result all there are significant difference with the pathological model group in " Chuan Xiong Tea soft capsule " high, medium and low dose groups, positive controls, matched group, TONGTIAN KOUFUYE group on biochemical indicators such as blood plasma viscosity, the high, medium and low shear value of whole blood viscosity, whole blood reduced viscosity, packed cell volume.
C, TONGTIAN KOUFUYE group all can obviously improve the rat blood parameters with " Chuan Xiong Tea soft capsule " high, medium and low dose groups, and with " Chuan Xiong Tea soft capsule " low dose group there was no significant difference (P>0.05)
Table 5 " Chuan Xiong Tea soft capsule " and TONGTIAN KOUFUYE comparing to the influence of rat serum rheology
Annotate: compare with matched group, ▲ P 0.01, ▲ ▲ P 0.05, the * P that compares with the pathological model group 0.01, * * P < 0.05
2.2 writhing method is " Chuan Xiong Tea soft capsule " and TONGTIAN KOUFUYE analgesic effect relatively
2.2.1 test grouping administering mode and dosage
Intact animal's blank group: 15 rats, pure water are only irritated stomach 5ml/, tid, 7d.
" Chuan Xiong Tea soft capsule " high dose group: 15 rats, press the crude drug amount and calculate 0.96mg.kg-1, tid, 7d.
Dose groups in " Chuan Xiong Tea soft capsule ": 15 rats, press the crude drug amount and calculate 0.48mg.kg-1, tid, 7d.
" Chuan Xiong Tea soft capsule " low dose group: 15 rats, press the crude drug amount and calculate 0.24mg.kg-1, tid, 7d.
The pathological model group: 15 rats, pure water are only irritated stomach 5ml/, tid, 7d.
Positive control drug (morphine) group: pure water is only irritated stomach 5ml/, and tid is behind the 7d.Lumbar injection 0.018mg.kg-1.
TONGTIAN KOUFUYE group: 0.9ml.kg-1, tid, 7d.
2.2.2 test method and result.
With 0.2ml/ normal saline of matched group lumbar injection
In addition only 0.5% acetic acid of lumbar injection 0.2ml/ is respectively organized in other tests, observed immediately and respectively organize the mouse writhing reaction times in the 15min, and statistical.The result sees table 6.
2.2.3 discuss:
A, the mouse writhing reaction times is respectively organized in test and there is significant difference in the matched group result, and positive controls, pathological model group real result are accurate, and whole experimental science is reasonable.
B, can find out that by experimental result all there are significant difference with the pathological model group in " Chuan Xiong Tea soft capsule " high, medium and low dose groups, positive controls, matched group, TONGTIAN KOUFUYE group in the mouse writhing reaction times.
C, TONGTIAN KOUFUYE group all can obviously improve the mouse writhing number of times with " Chuan Xiong Tea soft capsule " high, medium and low dose groups, and with " Chuan Xiong Tea soft capsule " low dose group there was no significant difference (P>0.05)
Table 6 " Chuan Xiong Tea soft capsule " and TONGTIAN KOUFUYE to the comparison of the analgesic activity of mice (x ± s, n=15)
Annotate: compare with matched group, ▲ P < 0.01
5. this Technology Chinese medicinal soft capsule dosage form of producing; In extraction process, select former traditional water decocting process for use; The precipitate with ethanol that has reduced existing oral liquid, tablet, granule extracts spissated technical process, has reduced cost, and only one of extraction process just reduces the cost nearly 10.
6. the soft capsule produced of this Technology; Improving dosage form " TONGTIAN KOUFUYE " with maximum " Chuanxiong Chatiao San " of present clinical employing compares not only taking convenience, is easy to carry; Also reduced packing cost, only oral liquid bottle is one, and every day, dosage reduced nearly 0.3 yuan of direct cost.And improved exterior quality, and improved the quality of tcm product, have international standard.
The specific embodiment of the present invention:
Embodiment 1:
The method for preparing of a kind of " Chuan Xiong Tea soft capsule "; It comprises: at first each flavor Chinese medicine is taken by weighing by weight proportion, wherein 200 parts of Rhizoma Chuanxiongs, 100 parts of Radix Paeoniae Rubra, 50 parts in Rhizoma Gastrodiae, 100 parts of Rhizoma Et Radix Notopterygiis, 100 parts of the Radixs Angelicae Dahuricae, 50 parts of Herba Asaris, 100 parts of Flos Chrysanthemis, 100 parts of Herba Menthaes, windproof 30 parts, 100 parts of Folium Camelliae sinensis, 50 parts in Radix Glycyrrhizae go mud to clean; Put it in the multi-functional Chinese medicine extraction pot; Decocte with water three times 1-2 hours for the first time, was respectively 1-1.5 hours for the second time, for the third time; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; To filtrate and under 60 ℃, be evaporated to relative density is 1.05, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for 20-50% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Gelatin to add pigment is processed capsule-core concrete oil substrate liquid as the capsule material, under 70 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is processed 100-500 soft capsules; Through dry, wash ball, drying makes soft capsule.
Embodiment 2:
The method for preparing of a kind of " Chuan Xiong Tea soft capsule "; It comprises: at first each flavor Chinese medicine is taken by weighing by weight proportion, wherein 127 parts of Rhizoma Chuanxiongs, 53 parts of Radix Paeoniae Rubra, 21 parts in Rhizoma Gastrodiae, 42 parts of Rhizoma Et Radix Notopterygiis, 42 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Asaris, 53 parts of Flos Chrysanthemis, 84 parts of Herba Menthaes, windproof 15 parts, 63 parts of Folium Camelliae sinensis, 21 parts in Radix Glycyrrhizae etc. go mud to clean; Put it in the multi-functional Chinese medicine extraction pot; Decocte with water three times 1-2 hours for the first time, was respectively 1-1.5 hours for the second time, for the third time; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; To filtrate and under 60 ℃, be evaporated to relative density is 1.05, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for 20-50% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Gelatin to add pigment is processed capsule-core concrete oil substrate liquid as the capsule material, under 70 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is processed 100-500 soft capsules; Through dry, wash ball, drying makes soft capsule.
Embodiment 3:
The method for preparing of embodiment 1 described " Chuan Xiong Tea soft capsule ": at first each flavor Chinese medicine is taken by weighing by weight proportion; Chinese crude drug such as 127 parts of Rhizoma Chuanxiongs, 53 parts of Radix Paeoniae Rubra, 21 parts in Rhizoma Gastrodiae, 42 parts of Rhizoma Et Radix Notopterygiis, 42 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Asaris, 53 parts of Flos Chrysanthemis, 5 parts of Herba Menthaes, windproof 15 parts, 63 parts of Folium Camelliae sinensis, 21 parts in Radix Glycyrrhizae wherein; Go mud to clean, put it in the multi-functional Chinese medicine extraction pot decocte with water three times; 1-2 hours for the first time, be respectively 1-1.5 hours for the second time, for the third time; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; To filtrate and under 60 ℃, be evaporated to relative density is 1.05, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; It is 120 order hermetically storings that armaticity Chinese crude drugs such as mentha leave are pulverized; The volatile oil that extracts is dissolved in a certain amount of edible oil; Wait other armaticity Chinese medicines to mix for 84 parts dry extract and Herba Menthae with the edible oil of the volatile oil that is dissolved with extraction; Dries such as dry extract account for 20-50% of oil matrix amount in the soft capsule, then mixture are carried out homogenizing with colloid mill and grind; Gelatin to add pigment is processed capsule-core concrete oil substrate liquid as the capsule material, under 70 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is processed 100-500 soft capsules; Through dry, wash ball, drying makes soft capsule.
Embodiment 4:
The method for preparing of embodiment 1 described " Chuan Xiong Tea soft capsule ": at first each flavor Chinese medicine is taken by weighing by weight proportion; Chinese crude drug such as 24 parts of Rhizoma Chuanxiongs, 24 parts of Herba Schizonepetae, 12 parts of Rhizoma Et Radix Notopterygiis, 12 parts of the Radixs Angelicae Dahuricae, 6 parts of Herba Asaris, windproof 9 parts, 12 parts in Radix Glycyrrhizae, 24 parts of Herba Menthaes, 10-50 parts of Folium Camelliae sinensis wherein; Go mud to clean, put it in the multi-functional Chinese medicine extraction pot decocte with water three times; 1-2 hours for the first time, be respectively 1-1.5 hours for the second time, for the third time; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; To filtrate and under 60 ℃, be evaporated to relative density is 1.05, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; It is 120 order hermetically storings that armaticity Chinese crude drugs such as mentha leave are pulverized; The volatile oil that extracts is dissolved in a certain amount of edible oil; Wait other armaticity Chinese medicines to mix for 84 parts dry extract and Herba Menthae with the edible oil of the volatile oil that is dissolved with extraction; Dries such as dry extract account for 20-50% of oil matrix amount in the soft capsule, then mixture are carried out homogenizing with colloid mill and grind; Gelatin to add pigment is processed capsule-core concrete oil substrate liquid as the capsule material, under 70 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is processed 100-500 soft capsules; Through dry, wash ball, drying makes soft capsule.
Embodiment 5:
The method for preparing of a kind of " Chuan Xiong Tea soft capsule "; It comprises: at first each flavor Chinese medicine is taken by weighing by weight proportion, wherein 127 parts of Rhizoma Chuanxiongs, 53 parts of Radix Paeoniae Rubra, 21 parts in Rhizoma Gastrodiae, 42 parts of Rhizoma Et Radix Notopterygiis, 42 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Asaris, 84 parts of Herba Menthaes, windproof 15 parts, 63 parts of Folium Camelliae sinensis, 21 parts in Radix Glycyrrhizae etc. go mud to clean; Put it in the multi-functional Chinese medicine extraction pot; Decocte with water three times 1-2 hours for the first time, was respectively 1-1.5 hours for the second time, for the third time; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; To filtrate and under 60 ℃, be evaporated to relative density is 1.05, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for 20-50% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Gelatin to add pigment is processed capsule-core concrete oil substrate liquid as the capsule material, under 70 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is processed 100-500 soft capsules; Through dry, wash ball, drying makes soft capsule.
Embodiment 6:
The method for preparing of a kind of " Chuan Xiong Tea soft capsule "; It comprises: at first each flavor Chinese medicine is taken by weighing by weight proportion, wherein 127 parts of Rhizoma Chuanxiongs, 53 parts of Radix Paeoniae Rubra, 50 parts in Rhizoma Gastrodiae, 42 parts of Rhizoma Et Radix Notopterygiis, 42 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Asaris, 53 parts of Flos Chrysanthemis, 84 parts of Herba Menthaes, windproof 15 parts, 63 parts of Folium Camelliae sinensis, 21 parts in Radix Glycyrrhizae etc. go mud to clean; Put it in the multi-functional Chinese medicine extraction pot; Decocte with water three times 1-2 hours for the first time, was respectively 1-1.5 hours for the second time, for the third time; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; To filtrate and under 60 ℃, be evaporated to relative density is 1.05, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for 20-50% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Gelatin to add pigment is processed capsule-core concrete oil substrate liquid as the capsule material, under 70 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is processed 100-500 soft capsules; Through dry, wash ball, drying makes soft capsule.
Embodiment 7:
The method for preparing of a kind of " Chuan Xiong Tea soft capsule "; It comprises: at first each flavor Chinese medicine is taken by weighing by weight proportion, wherein 127 parts of Rhizoma Chuanxiongs, 53 parts of Radix Paeoniae Rubra, 21 parts in Rhizoma Gastrodiae, 42 parts of Rhizoma Et Radix Notopterygiis, 42 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Asaris, 84 parts of Herba Menthaes, 10 parts of Flos Chrysanthemis, windproof 15 parts, 63 parts of Folium Camelliae sinensis, 21 parts in Radix Glycyrrhizae etc. go mud to clean; Put it in the multi-functional Chinese medicine extraction pot; Decocte with water three times 1-2 hours for the first time, was respectively 1-1.5 hours for the second time, for the third time; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; To filtrate and under 60 ℃, be evaporated to relative density is 1.05, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for 20-50% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Gelatin to add pigment is processed capsule-core concrete oil substrate liquid as the capsule material, under 70 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is processed 100-500 soft capsules; Through dry, wash ball, drying makes soft capsule.
Embodiment 8:
The method for preparing of a kind of " Chuan Xiong Tea soft capsule "; It comprises: at first each flavor Chinese medicine is taken by weighing by weight proportion, wherein 127 parts of Rhizoma Chuanxiongs, 53 parts of Radix Paeoniae Rubra, 2 parts in Rhizoma Gastrodiae, 42 parts of Rhizoma Et Radix Notopterygiis, 42 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Asaris, 84 parts of Herba Menthaes, 10 parts of Flos Chrysanthemis, windproof 15 parts, 63 parts of Folium Camelliae sinensis, 21 parts in Radix Glycyrrhizae etc. go mud to clean; Put it in the multi-functional Chinese medicine extraction pot; Decocte with water three times 1-2 hours for the first time, was respectively 1-1.5 hours for the second time, for the third time; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; To filtrate and under 60 ℃, be evaporated to relative density is 1.05, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for 20-50% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Gelatin to add pigment is processed capsule-core concrete oil substrate liquid as the capsule material, under 70 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is processed 100-500 soft capsules; Through dry, wash ball, drying makes soft capsule.
Claims (1)
1. the method for preparing of
a kind of Chuan Xiong Tea soft capsule is characterized in that: at first each flavor Chinese medicine is taken by weighing by weight proportion Rhizoma Chuanxiong 5-200 part wherein, Radix Paeoniae Rubra 1-100 part; Rhizoma Gastrodiae 1-50 part, Rhizoma Et Radix Notopterygii 5-100 part, Radix Angelicae Dahuricae 5-100 part, Herba Asari 5-50 part; Flos Chrysanthemi 1-100 part, Herba Menthae 5-100 part, windproof 5-30 part, Folium Camelliae sinensis 5-100 part; Radix Glycyrrhizae 5-50 part, Herba Schizonepetae 5-100 part goes mud to clean, and puts into the multi-functional Chinese medicine extraction pot; Soaked 1-2 hour, and decocted three times, 1-2 hour for the first time, be respectively for the second time, for the third time 1-1.5 hour; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; To filtrate and under 60-80 ℃, be evaporated to relative density is 1.05-1.10, then its spray drying is become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in or is emulsifiable in the edible oil; The edible oil of dry extract with the volatile oil that is dissolved with extraction mixed; Dry extract accounts for the 20-50% of oil matrix amount in the soft capsule, then mixture is carried out homogenizing with colloid mill and grinds, and processes capsule-core concrete oil substrate liquid; Add brown or red opaque pigment in the gelatin, the addition of pigment is the 0.5-5% of gelatin amount, is the capsule material with the gelatin, under 50-80 ℃ of stirring condition, capsule-core concrete oil substrate hydraulic pressure is processed soft capsule; Through dry, wash ball, drying makes soft capsule.
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| CN102178851B (en) * | 2011-04-08 | 2012-09-05 | 李世亮 | Medicament for treating nervous headache |
| CN103495042B (en) * | 2013-09-09 | 2015-04-15 | 徐如阳 | Traditional Chinese medicine composition for treating migraine |
| CN103800438B (en) * | 2014-02-24 | 2017-02-15 | 北京三泉医药技术有限公司 | Ligusticum wallichii tea modulator and preparation method thereof |
| CN104069175A (en) * | 2014-06-17 | 2014-10-01 | 王庚禹 | Extract used for preparing ligusticum wallichii tea modulator |
| CN104306440B (en) * | 2014-09-22 | 2018-02-09 | 海南葫芦娃药业集团股份有限公司 | A kind of Chuanxiong Chatiao San and preparation method thereof |
| CN105147915B (en) * | 2015-10-20 | 2020-07-14 | 黑龙江大学 | Yiganbao soft capsule and its preparation process |
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