CN103495042B - Traditional Chinese medicine composition for treating migraine - Google Patents
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- CN103495042B CN103495042B CN201310406785.8A CN201310406785A CN103495042B CN 103495042 B CN103495042 B CN 103495042B CN 201310406785 A CN201310406785 A CN 201310406785A CN 103495042 B CN103495042 B CN 103495042B
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Abstract
A traditional Chinese medicine composition for treating migraine relates to the technical field of Chinese herbal medicines, and is a medicament prepared from the following bulk drugs in parts by weight: 10-14 parts of ligusticumwallichii, 8-12 parts of angelica dahurica, 7-11 parts of notopterygium root, 7-11 parts of xanthium, 7-11 parts of radix bupleuri, 7-11 parts of fructusviticis, 1-5 parts of asarum herb and 10-14 parts of rhizomagastrodiae. The traditional Chinese medicine composition is accord with traditional Chinese medicine syndrome differentiation theory on traditional Chinese medicinal material selection and compatibility; the traditional Chinese medicine composition has the advantages of simple preparation method, fast effectiveness, high cure rate, uneasiness in recurrence and the like; and the traditional Chinese medicine composition has the effects of dispersing swelling and detoxifying, activating blood and dissipating binds, clearing heat and detoxifying, dispersing wind and relieving pain, relieving migraine and headache, tonifying fire and restoring yang, warming the middle and relieving pain, drying dampness and resolving phlegm, soothing the middle and dispersing stuffiness, relieving fainting and pain, nourishing blood and constraining yin, relaxing tension and relieving pain, pacifying liver and extinguishing wind, calming fright and reliving pain, inducing diuresis, clearing heat and relieving fainting, warming the middle and expelling stagnation.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, being specifically related to a kind of for controlling migrainous Chinese medicine composition.
Background technology
Migraine is a kind of pulsatile headache of recurrent exerbation, belong to the one in numerous headache type, the tendencys such as flash of light, blurred vision, numb limbs and tense tendons are often had before its outbreak, few minutes to 1 hours occurs that side head one jumps a pain of choosing, and aggravate gradually, until after there is Nausea and vomiting, sensation just has and taken a turn for the better, headache relief in peace and quiet, dark surrounds or after sleep, makes patient suffering can't bear.
In migrainous treatment, doctor trained in Western medicine is commonly used the medicine such as pizotifen, amitriptyline to treat, and substantially all has some curative effects, but can only take stopgap measures and can not effect a permanent cure, and the side effect of these medicines is a lot, especially very large to lesions of liver and kidney, just relief of symptoms, cannot play the object of thoroughly curing.
Summary of the invention
It is high that technical problem to be solved by this invention is to provide a kind of cure rate, safe and reliable for controlling migrainous Chinese medicine composition.
Technical problem to be solved by this invention realizes by the following technical solutions:
One is used for controlling migrainous Chinese medicine composition, the medicament be made up of the crude drug of following weight portion,
Rhizoma Chuanxiong 10-14 part, Radix Angelicae Dahuricae 8-12 part, Rhizoma Et Radix Notopterygii 7-11 part, Fructus Xanthii 7-11 part, Radix Bupleuri 7-11 part, Fructus Viticis 7-11 part, Herba Asari 1-5 part, Rhizoma Gastrodiae 10-14 part.
Preferred weight part of each crude drug is:
Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Rhizoma Et Radix Notopterygii 9 parts, Fructus Xanthii 9 parts, Radix Bupleuri 9 parts, Fructus Viticis 9 parts, Herba Asari 3 parts, 12 parts, Rhizoma Gastrodiae.
Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., the conventional oral formulations of any one is prepared into the method for Chinese medicinal of routine, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method preparing the present composition, comprises the steps,
1) each crude drug is taken by following parts by weight: Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Rhizoma Et Radix Notopterygii 9 parts, Fructus Xanthii 9 parts, Radix Bupleuri 9 parts, Fructus Viticis 9 parts, Herba Asari 3 parts, 12 parts, Rhizoma Gastrodiae;
2) above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, can add after preparation commonly uses adjuvant or carrier in decoction, preparations shaping, obtains pill, capsule or tablet.
1, pharmacology analysis:
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.
The Radix Angelicae Dahuricae: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.
Rhizoma Et Radix Notopterygii: acrid in the mouth; Bitter; Warm in nature.Loose exterior cold; Wind-damp dispelling; Profit joint; Pain relieving.
Fructus Xanthii: acrid in the mouth, hardship, warm in nature, poisonous.Return lung meridian.There is the function of the dehumidifying of loose wind, understand things pain-stopping.
Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian.Point out in " book on Chinese herbal medicine justice ", headache bulge of the ear can be treated, the diseases such as dizzy vomiting, distending pain over the hypochondrium.
Fructus Viticis: " book on Chinese herbal medicine newly organized ": Fructus Viticis, bitter in the mouth, pungent, sweet, temperature, to be slightly cold, the YIN aspect of YANG is nontoxic.Enter Taiyang channel.Main muscles and bones cold and heat, arthralgia chiefly caused by damp pathogen contracture, herbal classic is had a headache, and head heavy dusk is vexed, sharp joint, long hair, logical nine orifices, debug, and loose wind is excessive, improving eyesight, and tinnitus is only.
Herba Asari: eliminate suppurative mastitis inflammation; Mass dissipating and swelling eliminating; Induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; The therapeutic method to keep the adverse QI flowing downwards is eliminated the phlegm, sensible.
Rhizoma Gastrodiae: Gan Ping, returns Liver Channel.Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.
2, usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.Instruction: decoction, gets an auxiliary medicine, is boiled into decoction, and every day one is secondary, within 7 days, is a course for the treatment of.
3, the present composition has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:
1) animal acute toxicity test is carried out to decoction prepared by the present invention:
Medicine: the crude drug used by the present invention is bought from common Chinese shop and obtained, and its specification meets national Chinese crude drug standard.
Experimental animal: white mice, body weight is at about 50g, and male and female Stochastic choice, is bought by market.
Method and result: get white mice 30, hungry 20 hours, feeding 50ml by filling with several times every every day, feeding one week continuously, observing 10 days, and mice is movable normal, non-toxic reaction, without dead.Show that oral liquid is without acute toxicity, clinical medicine dose safety.
2) long-term toxicity test for animals is carried out to decoction prepared by the present invention:
Experimental animal: rat, body weight is at 120-130g, and male and female Stochastic choice, is bought by market.
Method and result: get rat 20, be divided into 2 groups, often organize 10, wherein the 1st group as administration group, 40-50ml is fed by filling with several times every every day, 2nd group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, equal non-toxic reaction, a kind of safe drugs.
4, diagnostic criteria
1) how repeatedly clinical diagnosis: headache mostly is inclined side, generally continue 4 ~ 72 hours, with Nausea and vomiting.
2) in order to verify clinical efficacy, this prescription is tried out in Affiliated Hospital of Chinese medicine institute first of Anhui Province respectively, and random selecting is 50 routine migraine patients wherein.
3) Therapeutic Method: according to drug ratios of the present invention, takes raw material (dose), and the foundation usually method of decocting medicinal herbs obtains decoction, and every day one is secondary, and taking 7 days is a course for the treatment of, the shortest 2 courses for the treatment of, the longest half a year.
4) efficacy determination:
Recovery from illness: migraine and related symptoms all disappear, and do not affect orthobiosis and work; Effective: migraine and related symptoms disappear substantially, after treatment, symptom obviously alleviates, and does not affect daily life and work; Effective: related symptoms and sign are improved, but unstable condition, there is recurrence after drug withdrawal; Invalid: to treat rear symptom, sign compared with before treatment without any change; Concrete therapeutic outcome is see table 1.
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 50 | 5 | 30 | 10 | 5 | 90 |
5, points for attention:
1. diet should be light, gives up alcohol and pungent, raw and cold, greasy food.
2. child, women breast-feeding their children, elderly and infirm should take under doctor instructs.
3. driver, work high above the ground person are cautious use of.
4. strictly take by usage and dosage, this medicine should not be taken for a long time in a large number.
5. pair this medicine and alcohol intolerance person forbidding, allergic constitution person be cautious use of.
6. prohibit the use when this property of drug changes.
7. please this medicine is placed on the place that child can not contact.
8. as used other medicines, please Ref Dr or pharmacist before using this medicine.
The invention has the beneficial effects as follows: the present invention selects at Chinese crude drug and compatibility meets Chinese medical discrimination theory, and compound method simply, and have rapid-action, cure rate is high, not easily the advantage such as recurrence.Subduing swelling and detoxicating, blood circulation promoting and dispersing pathogen accumulation, heat-clearing and toxic substances removing, loose wind relieves the pain, only migraine and general headache, and mend fiery recuperating depleted YANG, warming middle-JIAO relieves the pain, drying dampness to eliminate phlegm, and alleviating distention in middle-JIAO disappears painful abdominal mass, and relieving fainting relieves the pain, and nourish blood yin fluid astringing, relieving spasm to stop pain, suppressing the hyperactive liver to relieve the wind syndrome, arresting convulsion pain relieving, diuretic heat clearing away relieving fainting, warming middle-JIAO dissipating depression of QI.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Take each crude drug: Rhizoma Chuanxiong 12g, Radix Angelicae Dahuricae 10g, Rhizoma Et Radix Notopterygii 9g, Fructus Xanthii 9g, Radix Bupleuri 9g, Fructus Viticis 9g, Herba Asari 3g, Rhizoma Gastrodiae 12g.Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, every day one is secondary, and taking 7 days is a course for the treatment of.
Embodiment 2
Each crude drug is taken: Rhizoma Chuanxiong 13g, Radix Angelicae Dahuricae 9g, Rhizoma Et Radix Notopterygii 10g, Fructus Xanthii 8g, Radix Bupleuri 10g, Fructus Viticis 8g, Herba Asari 4g, Rhizoma Gastrodiae 11g by following parts by weight.Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, every day one is secondary, and taking 7 days is a course for the treatment of.
Embodiment 3
Each crude drug is taken: Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 8g, Rhizoma Et Radix Notopterygii 7g, Fructus Xanthii 7g, Radix Bupleuri 7g, Fructus Viticis 7g, Herba Asari 1g, Rhizoma Gastrodiae 10g by following parts by weight.Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, every day one is secondary, and taking 7 days is a course for the treatment of.
Model case:
Case 1
Permit so-and-so, man, 65 years old, divorced retired cadre, Tao Miao people from town, Jieshou City, Anhui Province, because of direct stimulation burst side local pain, have a headache for pulsation or drilling pain, simultaneously with anorexia, vomiting, feel sick, after taking 3 courses for the treatment of of decoction of the present invention, symptom alleviates, after take again 6 courses for the treatment of continuously, fully recover latter 1 year with anti-, do not recur.
Case 2
Jiang, female, 48 years old, peasant, because transition is worried about in fatigue, there is migraine in Jin stockaded village, Jieshou City, Anhui Province village people, through looking into, all muscle tones of cranium increase to cause lastingly has a headache for non-pulsation, tightens sense, sense of heaviness.After taking 4 courses for the treatment of of decoction of the present invention, symptom alleviates, after take again 6 courses for the treatment of continuously, fully recover latter 1 year with anti-, do not recur.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (1)
1. for controlling a migrainous Chinese medicine composition, it is characterized in that, the medicament be made up of the crude drug of following weight portion: Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Rhizoma Et Radix Notopterygii 9 parts, Fructus Xanthii 9 parts, Radix Bupleuri 9 parts, Fructus Viticis 9 parts, Herba Asari 3 parts, 12 parts, Rhizoma Gastrodiae; During preparation, above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.
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| CN103908506A (en) * | 2014-03-31 | 2014-07-09 | 青岛百瑞吉生物工程有限公司 | Traditional Chinese medicinal preparation for treating migraine, preparation method and application thereof |
| CN104147388B (en) * | 2014-08-25 | 2015-04-29 | 王桂霞 | Traditional Chinese medicine composition for treating migraine and preparation method thereof |
| CN105194191A (en) * | 2015-11-06 | 2015-12-30 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine composition for treating tension headache |
| CN106361901A (en) * | 2016-10-13 | 2017-02-01 | 李书林 | Traditional Chinese medicine preparation for treating long-term headache |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600333A (en) * | 2003-09-28 | 2005-03-30 | 钟厚尧 | Painkiller |
| CN101327302A (en) * | 2007-06-18 | 2008-12-24 | 黑龙江大学 | Chuan Xiong Tea soft capsule and method for preparing the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600333A (en) * | 2003-09-28 | 2005-03-30 | 钟厚尧 | Painkiller |
| CN101327302A (en) * | 2007-06-18 | 2008-12-24 | 黑龙江大学 | Chuan Xiong Tea soft capsule and method for preparing the same |
Non-Patent Citations (1)
| Title |
|---|
| 川芎茶调散治疗头痛的体会;谢华;《中原医刊》;19920430(第2期);第22-23页 * |
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