CN1600333A - Painkiller - Google Patents
Painkiller Download PDFInfo
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- CN1600333A CN1600333A CN 03135096 CN03135096A CN1600333A CN 1600333 A CN1600333 A CN 1600333A CN 03135096 CN03135096 CN 03135096 CN 03135096 A CN03135096 A CN 03135096A CN 1600333 A CN1600333 A CN 1600333A
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Abstract
An antalgic Chinese medicine for treating headache, hemicrania, toothache, rheumatalgia, menalgia, etc. is prepared from 4 Chinese-medicinal materials: gastrodia tuber, dahurian angelica root, Chuan-xiong rhizome and shrub chastetree fruit.
Description
Technical field
The present invention relates to a kind of is the medicinal preparation of component with animal and vegetable Chinese herbal medicine active ingredient, particularly a kind of analgesic that is used for the treatment of various pain diseases.
Background technology
Various neuropathic pains such as headache, migraine, toothache, rheumatalgia, shank pain are multiple disease, its sickness rate height, and longer duration brings inconvenience and misery to the patient.To be used for the treatment of the therapeutic effect of these ailing medicines comparatively general for field of medicaments now, perhaps generally can only treat wherein a certain or a few is ailing.
Summary of the invention
The objective of the invention is to overcome weak point of the prior art, can treat ailing and good, the rapid-action analgesic of therapeutic effect of nerves such as various headaches, migraine, toothache, rheumatalgia, shank pain and provide a kind of.
Purpose of the present invention can realize through following scheme.
Analgesic, it is formed main points and is that it comprises following component: Rhizoma Gastrodiae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong and Fructus Viticis.
Rhizoma Gastrodiae has the effect of suppressing the hyperactive liver, endogenous wind stopping, relieving convulsion; The Radix Angelicae Dahuricae has expelling wind and removing dampness, arranges functions such as dense granulation promoting, invigorating blood circulation analgesia; Rhizoma Chuanxiong has the effect of blood-activating and qi-promoting, wind-expelling pain-stopping; Fructus Viticis has dispelling wind and heat pathogens, the clear sharp head's effect.
And vim and vigour running, general rule are not bitterly, add Rhizoma Chuanxiong in this analgesic and can help the human qi and blood running, drive the absorption of human body to other medicines simultaneously, increase curative effect.
Fructus Viticis and Rhizoma Chuanxiong are joined, but promoting blood circulation by removing wind is a principal agent with the Rhizoma Chuanxiong, and Fructus Viticis is an accessory drugs, though their effect is not quite similar, but accessory drugs can improve the principal agent curative effect.
Confirm after deliberation, they form analgesic according to the Chinese medicine mutual reinforcement between for the compatibility theory prescription with, the promoting the circulation of blood of regulating the flow of vital energy, produced the effect of Synergistic, carrying out pathology, poison of drug experiment and secular clinical experiment through drug discovery assay base Medical University Of Fujian of National Drug Administration shows, according to the analgesic that this prescription is produced, its treatment effective percentage reaches more than 90%.
And the toxic and side effects of the Chinese patent medicine that is made according to Chinese herbal medicine is little, can to the human body Liver and kidney certain injury not arranged as Western medicine, thereby this medicine is applied widely.
Moreover; observation on Clinical Application according to long-term numerical example; take this medicine and be used to treat the patient of various pain; great majority no longer recur after healing; certainly can not form yet and rely on this medicine; and for the similar analgesic that has field of medicaments now; patient can form dependence usually after taking; taking pain when being the pain outbreak can end; but repeat outbreak easily, need long-term prescription, can't thoroughly effect a radical cure; and the radical rate height of this Drug therapy pain, this is a non-obvious beneficial effect of the present invention.
Wherein, each component is that the consumption of unit is with the weight portion in this analgesic: 10～14 parts in Rhizoma Gastrodiae, 10～13 parts of the Radixs Angelicae Dahuricae, 8～12 parts of Rhizoma Chuanxiongs, 2～4 parts of Fructus Viticises.
Purpose of the present invention can also realize through following scheme.
Analgesic also comprises with the weight portion being 10～12 parts of the Bombyx Batryticatus of unit.
Bombyx Batryticatus can be controlled polarization wind syndrome of head, chuck wind, two temple pain, headache and wind carious pain etc. suddenly.Add Bombyx Batryticatus and can increase this analgesic analgesic effect.
Analgesic also comprises with the weight portion being 12～14 parts of the Rhizoma alpiniae chinensis of unit.
Rhizoma Et Radix Notopterygii has that cold expelling dispels the wind, the effect of removing damp and stopping pain, is used for equally and other component Synergistic.
Analgesic also comprises with the weight portion being 8～12 parts of the Rhizoma Corydalis of unit.
Rhizoma Corydalis can be invigorated blood circulation, promoting the circulation of QI, pain relieving, and it is hot to loose, hardship is let out, temperature is led to, and has both gone into blood system, goes into edema caused by disorder of QI again, the gas in can promoting the circulation of blood, and the blood in again can circulation of qi promoting, thereby the smooth blood of gas is capable, general rule is not bitterly.
Analgesic also comprises with the weight portion being 8～14 parts of the Radix Puerariaes of unit.
Radix Puerariae can cure the wound cold, warm headache, and dysentery, skin eruption are not saturating, angina pectoris etc.
Analgesic also comprises with the weight portion being 8～12 parts of the Radix Saposhnikoviaes of unit.
Radix Saposhnikoviae has delivers, dispels the wind, wins effect wet, pain relieving, and it joins Rhizoma Et Radix Notopterygii, reaches on certainly in the whole body, and the effect of dispelling wind removing dampness to relieve pain is arranged, kind dispelling the wind and dampness pathogens at table last, migraine and general headache, heavy sensation of the body arthralgia person.
Analgesic also comprises with the weight portion being 4～6 parts of the Radix Achyranthis Bidentatae of unit.
Radix Achyranthis Bidentatae has another name called Radix Achyranthis Bidentatae, has the effect of blood circulation promoting and blood stasis dispelling, conducting blood to flow downwards, and it is partial to blood system, and edema caused by disorder of QI is gone in anti-windage yaw, and QI and blood is ruled together, and mutual reinforcement between is a usefulness, auxilliary mutually help.
The present invention also is
Analgesic also comprises with the weight portion being 4～8 parts of the Radix Platycodoniss of unit.
Radix Platycodonis has out lung qi dispersing gas, the effect of the evacuation of pus of eliminating the phlegm, and it can play the effect of the mutual-assistance for using with the Radix Angelicae Dahuricae.
Show through secular clinical experiment: the treatment total effective rate of this analgesic reaches more than 99%, and curative effect is rapid, is applicable to multiple pain disease, for example headache, migraine, toothache, rheumatalgia, shank pain, dysmenorrhea etc., and have no side effect, old and young suitable.
Wherein, Zui Jia analgesic (is unit with the weight portion) contains following component: 12 parts in Rhizoma Gastrodiae, 11.5 parts of the Radixs Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiongs, 3 parts of Fructus Viticises, 11 parts of Bombyx Batryticatus, 13 parts of Rhizoma alpiniae chinensis, 10 parts of Rhizoma Corydalis, 11 parts of Radix Puerariaes, 10 parts of Radix Saposhnikoviaes, 5 parts of Radix Achyranthis Bidentatae, 6 parts of Radix Platycodoniss.
The analgesic that adopts above-mentioned each component combination and get, wherein the existing tcm field technical staff of the Chinese medicine weight ratio consumption of each component also can determine it according to the Chinese medicine conventional amount used.
Have unusual mature technique scheme in the prior art and various tablets, granule, pill, oral liquid or the like Chinese patent medicine dosage form can be extracted and made to the active ingredient of Chinese herbal medicine.For example can be called for short that " manufacture method of the various Chinese patent medicine dosage forms of record is made this analgesic in 2000 editions second one of the Chinese pharmacopoeia according to the Pharmacopoeia of the People's Republic of China, again for example " pharmaceutics " (People's Health Publisher, Tu Xide etc.) third edition all has detailed record to the preparation of various pharmaceutical dosage forms.
In sum, the present invention has following advantage compared to prior art: be applicable to multiple pain disease, for example headache, migraine, toothache, rheumatalgia, shank pain, dysmenorrhea etc., its curative effect is rapid, the treatment total effective rate reaches more than 99%, and have no side effect, old and young suitable, patient can not form dependence to this medicine.
The specific embodiment
Below in conjunction with embodiment, analgesic test and clinical case the present invention is described in more detail.
Embodiment 1:
Analgesic, it contains with the weight portion is the following component of unit: 14 parts in Rhizoma Gastrodiae, 13 parts of the Radixs Angelicae Dahuricae, 12 parts of Rhizoma Chuanxiongs, 4 parts of Fructus Viticises.The dosage form of this analgesic is a tablet.
Embodiment 2:
Analgesic, it contains with the weight portion is the following component of unit: 10 parts in Rhizoma Gastrodiae, 10 parts of the Radixs Angelicae Dahuricae, 8 parts of Rhizoma Chuanxiongs, 2 parts of Fructus Viticises, 12 parts of Bombyx Batryticatus.The dosage form of this analgesic is a pill.
Embodiment 3:
Analgesic, it contains with the weight portion is the following component of unit: 11 parts in Rhizoma Gastrodiae, 11 parts of the Radixs Angelicae Dahuricae, 8 parts of Rhizoma Chuanxiongs, 3 parts of Fructus Viticises, 10 parts of Bombyx Batryticatus, 14 parts of Rhizoma alpiniae chinensis.The dosage form of this analgesic is a granule.
Embodiment 4:
Analgesic, it contains with the weight portion is the following component of unit: 10 parts in Rhizoma Gastrodiae, 10 parts of the Radixs Angelicae Dahuricae, 9 parts of Rhizoma Chuanxiongs, 3 parts of Fructus Viticises, 12 parts of Bombyx Batryticatus, 12 parts of Rhizoma alpiniae chinensis, 8 parts of Rhizoma Corydalis.The dosage form of this analgesic is an oral liquid.
Embodiment 5:
Analgesic, it contains with the weight portion is the following component of unit: 12 parts in Rhizoma Gastrodiae, 12 parts of the Radixs Angelicae Dahuricae, 11 parts of Rhizoma Chuanxiongs, 2 parts of Fructus Viticises, 12 parts of Bombyx Batryticatus, 13 parts of Rhizoma alpiniae chinensis, 12 parts of Rhizoma Corydalis, 8 parts of Radix Puerariaes.The dosage form of this analgesic is a tablet.
Embodiment 6:
Analgesic, it contains with the weight portion is the following component of unit: 14 parts in Rhizoma Gastrodiae, 12 parts of the Radixs Angelicae Dahuricae, 11 parts of Rhizoma Chuanxiongs, 3 parts of Fructus Viticises, 10 parts of Bombyx Batryticatus, 13 parts of Rhizoma alpiniae chinensis, 12 parts of Rhizoma Corydalis, 14 parts of Radix Puerariaes, 8 parts of Radix Saposhnikoviaes.The dosage form of this analgesic is a pill.
Embodiment 7:
Analgesic, it contains with the weight portion is the following component of unit: 12 parts in Rhizoma Gastrodiae, 12 parts of the Radixs Angelicae Dahuricae, 11 parts of Rhizoma Chuanxiongs, 2 parts of Fructus Viticises, 12 parts of Bombyx Batryticatus, 13 parts of Rhizoma alpiniae chinensis, 12 parts of Rhizoma Corydalis, 8 parts of Radix Puerariaes, 12 parts of Radix Saposhnikoviaes, 4 parts of Radix Achyranthis Bidentatae.The dosage form of this analgesic is a granule.
Embodiment 8:
Analgesic, it contains with the weight portion is the following component of unit: 12 parts in Rhizoma Gastrodiae, 12 parts of the Radixs Angelicae Dahuricae, 11 parts of Rhizoma Chuanxiongs, 2 parts of Fructus Viticises, 12 parts of Bombyx Batryticatus, 13 parts of Rhizoma alpiniae chinensis, 12 parts of Rhizoma Corydalis, 8 parts of Radix Puerariaes, 10 parts of Radix Saposhnikoviaes, 6 parts of Radix Achyranthis Bidentatae, 4 parts of Radix Platycodoniss.The dosage form of this analgesic is an oral liquid.
Embodiment 9:
Analgesic, it contains with the weight portion is the following component of unit: 12 parts in Rhizoma Gastrodiae, 12 parts of the Radixs Angelicae Dahuricae, 11 parts of Rhizoma Chuanxiongs, 2 parts of Fructus Viticises, 12 parts of Bombyx Batryticatus, 13 parts of Rhizoma alpiniae chinensis, 12 parts of Rhizoma Corydalis, 8 parts of Radix Puerariaes, 10 parts of Radix Saposhnikoviaes, 6 parts of Radix Achyranthis Bidentatae, 8 parts of Radix Platycodoniss.The dosage form of this analgesic is a pill.
Embodiment 10:
Analgesic, it contains with the weight portion is the following component of unit: 12 parts in Rhizoma Gastrodiae, 11.5 parts of the Radixs Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiongs, 3 parts of Fructus Viticises, 11 parts of Bombyx Batryticatus, 13 parts of Rhizoma alpiniae chinensis, 10 parts of Rhizoma Corydalis, 11 parts of Radix Puerariaes, 10 parts of Radix Saposhnikoviaes, 5 parts of Radix Achyranthis Bidentatae, 6 parts of Radix Platycodoniss.The dosage form of this analgesic is a tablet.
The described analgesic of the various embodiments described above extracts the technology that active ingredient makes various dosage forms from Chinese herbal medicine same as the prior art.
Below for adopting analgesic provided by the invention mice to be carried out the record of analgesic experiment:
One, test drug
Analgesic faces with five times of preceding dilutions.
Two, experimental animal
Kunming mouse is provided by Medical University Of Fujian's Experimental Animal Center.
Three, test method and brief introduction as a result
1, test method: adopt hot plate method, writhing response method and electricity irritation Mus tail method, take the mouse stomach mode, the part by weight of drug dosage and mice body weight is between 20ml/Kg～100ml/Kg, and negative control group, dolantin matched group are also established in test.
2, result of the test: above-mentioned three kinds of analgesic test show that all analgesic has significant analgesic activity, and present dose-effect relationship preferably.
Enumerating some below adopts analgesic to treat the case of various pain.
One, the Fuqing sound Xi Zhen village Lin that goes downstairs, 60 years old, migraine for many years, other town's headache medicines of drink-service can't be eradicated for many years.Take a course of treatment of analgesic provided by the invention (10 days), this elimination of having a headache.
Two, the electrician Zeng of Fuqing Hong Lu power supply station, injured by a crashing object head by electric pole, porcelain vase accidentally because of constructing several years ago, cause regular headache behind the Wound healing, especially seasonal variations, headache obviously, taking other drug does not have obvious curative effects, takes analgesic provided by the invention drug withdrawal after one week, and this person is no headache outbreak symptom more over one year.
Three, east, Fuqing Zhang Zhen Shang Zhang village young woman, because of the flu of having a cold, whole body pain, groan is felt bad, and promptly ends through taking analgesic provided by the invention half an hour headache, and curative effect is obvious.
Four, the top of city wall, Fuqing town Zheng, 63 years old, existing 6 years of migraine was taken multiple analgesic, but outbreak often, through obeying two courses of treatment of analgesic provided by the invention (20 days), migraine is thoroughly eradicated.
Five, Fuqing Yu Xi town Lin violates the ailment said due to cold or exposure foul disease, and severe headache is taken 3 in analgesic tablet provided by the invention, pain short stopping in half an hour.
Six, the engineer opens in geology detecting five teams in Fujian, has a cold and causes regular headache because of construction outside all the year round, take analgesic provided by the invention after two courses of treatment the state of an illness take a turn for the better at once.
Claims (10)
1, analgesic is characterized in that, it comprises following component: Rhizoma Gastrodiae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong and Fructus Viticis.
2, analgesic according to claim 1 is characterized in that, each component is that the consumption of unit is with the weight portion: 10～14 parts in Rhizoma Gastrodiae, 10～13 parts of the Radixs Angelicae Dahuricae, 8～12 parts of Rhizoma Chuanxiongs, 2～4 parts of Fructus Viticises.
3, analgesic according to claim 1 is characterized in that, also comprises with the weight portion being 10～12 parts of the Bombyx Batryticatus of unit.
4, analgesic according to claim 1 is characterized in that, also comprises with the weight portion being 12～14 parts of the Rhizoma alpiniae chinensis of unit.
5, analgesic according to claim 1 is characterized in that, also comprises with the weight portion being 8～12 parts of the Rhizoma Corydalis of unit.
6, analgesic according to claim 1 is characterized in that, also comprises with the weight portion being 8～14 parts of the Radix Puerariaes of unit.
7, analgesic according to claim 4 is characterized in that, also comprises with the weight portion being 8～12 parts of the Radix Saposhnikoviaes of unit.
8, analgesic according to claim 7 is characterized in that, also comprises with the weight portion being 4～6 parts of the Radix Achyranthis Bidentatae of unit.
9, analgesic according to claim 1 is characterized in that, also comprises with the weight portion being 4～8 parts of the Radix Platycodoniss of unit.
10, analgesic according to claim 1 is characterized in that, it contains with the weight portion is the following component of unit: 12 parts in Rhizoma Gastrodiae, 11.5 parts of the Radixs Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiongs, 3 parts of Fructus Viticises, 11 parts of Bombyx Batryticatus, 13 parts of Rhizoma alpiniae chinensis, 10 parts of Rhizoma Corydalis, 11 parts of Radix Puerariaes, 10 parts of Radix Saposhnikoviaes, 5 parts of Radix Achyranthis Bidentatae, 6 parts of Radix Platycodoniss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031350968A CN100569269C (en) | 2003-09-28 | 2003-09-28 | Analgesic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031350968A CN100569269C (en) | 2003-09-28 | 2003-09-28 | Analgesic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1600333A true CN1600333A (en) | 2005-03-30 |
| CN100569269C CN100569269C (en) | 2009-12-16 |
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ID=34659208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031350968A Expired - Fee Related CN100569269C (en) | 2003-09-28 | 2003-09-28 | Analgesic |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100569269C (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600344A (en) * | 2012-03-26 | 2012-07-25 | 贺兰 | Medicine for treating toothache |
| CN102600369A (en) * | 2011-01-20 | 2012-07-25 | 北京联馨药业有限公司 | Traditional Chinese medicine composition for treating migraine, as well as preparation method and usage thereof |
| CN103495042A (en) * | 2013-09-09 | 2014-01-08 | 徐如阳 | Traditional Chinese medicine composition for treating migraine |
| CN101337031B (en) * | 2008-04-18 | 2014-06-18 | 张恒浩 | Baicao pill for curing dysmenorrheal |
| CN104107277A (en) * | 2014-07-03 | 2014-10-22 | 河南科技大学第一附属医院 | Mouthwash capable of alleviating toothache and preparation method thereof |
| CN105213996A (en) * | 2015-11-06 | 2016-01-06 | 青岛麦瑞特医药技术有限公司 | A kind of pharmaceutical composition for the treatment of cerebral vasospasm headache |
| CN106822614A (en) * | 2017-03-28 | 2017-06-13 | 陈振海 | A kind of pure Chinese medicine medicine and application method for treating antimigraine |
| CN107982334A (en) * | 2017-12-30 | 2018-05-04 | 佛山市赛普斯科技服务有限公司 | A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood |
| CN109331133A (en) * | 2018-12-25 | 2019-02-15 | 佛山科学技术学院 | Treat the Chinese medicine composition of migraine, the preparation method of pharmaceutical preparation and oral solution |
-
2003
- 2003-09-28 CN CNB031350968A patent/CN100569269C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101337031B (en) * | 2008-04-18 | 2014-06-18 | 张恒浩 | Baicao pill for curing dysmenorrheal |
| CN102600369A (en) * | 2011-01-20 | 2012-07-25 | 北京联馨药业有限公司 | Traditional Chinese medicine composition for treating migraine, as well as preparation method and usage thereof |
| CN102600344A (en) * | 2012-03-26 | 2012-07-25 | 贺兰 | Medicine for treating toothache |
| CN102600344B (en) * | 2012-03-26 | 2013-07-17 | 贺兰 | Medicine for treating toothache |
| CN103495042A (en) * | 2013-09-09 | 2014-01-08 | 徐如阳 | Traditional Chinese medicine composition for treating migraine |
| CN103495042B (en) * | 2013-09-09 | 2015-04-15 | 徐如阳 | Traditional Chinese medicine composition for treating migraine |
| CN104107277A (en) * | 2014-07-03 | 2014-10-22 | 河南科技大学第一附属医院 | Mouthwash capable of alleviating toothache and preparation method thereof |
| CN105213996A (en) * | 2015-11-06 | 2016-01-06 | 青岛麦瑞特医药技术有限公司 | A kind of pharmaceutical composition for the treatment of cerebral vasospasm headache |
| CN106822614A (en) * | 2017-03-28 | 2017-06-13 | 陈振海 | A kind of pure Chinese medicine medicine and application method for treating antimigraine |
| CN107982334A (en) * | 2017-12-30 | 2018-05-04 | 佛山市赛普斯科技服务有限公司 | A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood |
| CN109331133A (en) * | 2018-12-25 | 2019-02-15 | 佛山科学技术学院 | Treat the Chinese medicine composition of migraine, the preparation method of pharmaceutical preparation and oral solution |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100569269C (en) | 2009-12-16 |
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Granted publication date: 20091216 Termination date: 20120928 |