CN107982334A - A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood - Google Patents
A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood Download PDFInfo
- Publication number
- CN107982334A CN107982334A CN201711493366.7A CN201711493366A CN107982334A CN 107982334 A CN107982334 A CN 107982334A CN 201711493366 A CN201711493366 A CN 201711493366A CN 107982334 A CN107982334 A CN 107982334A
- Authority
- CN
- China
- Prior art keywords
- parts
- blood
- stasis
- chinese medicine
- herb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The present invention provides the Chinese medicine preparation that a kind of heat-clearing dissipates the stasis of blood, it is made of following raw material and parts by weight：Dragon-boat spend 11~23 parts, 9~21 parts of Lysimachia capillipes Hemsl, 8~24 parts of Strobilanthes aehobarbus W. W. Smith, 15~27 parts of naringi crenulata, 6~18 parts of sivery aleuritopteris herb, 8~24 parts of small hancock swallowwort herb, 5~25 parts of madder, 10~30 parts of Samson St Johswort, 11~23 parts of purple back of the body grass, 12~24 parts of dichrocephala, 9~21 parts of auspicious Siberian cocklebur grass, 12~20 parts of conical silene herb, 8~16 parts of radix glycyrrhizae.The extracting method of the formula of the present invention includes：Raw material preliminary drying, isothermal immersion, alcohol extracting, water extraction, be made major function composition.This formula compatibility is reasonable, there is preferable blood-nourishing to dissipate the effect of stasis of blood pharmacological function, therapeutic effect is good, has no toxic side effect to human body.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine formula and its extracting method, and in particular to a kind of to have effects that heat-clearing is dissipated in the stasis of blood
Medicine composition and its Advanced method.
Background technology
Think in the angle of the traditional Chinese medical science, the pain of human body, it is obstructed to come from qi and blood mostly.Especially women common disease,
Such as situations such as antimigraine, dysmenorrhoea.The treatment method of doctor trained in Western medicine, is typically to open to take anodyne, and anodyne is typically nerve blocker, only
It can play the role of taking stopgap measures, it is impossible to effect a permanent cure.From Chinese medicine angle, it is believed that the lenitive method of effecting a permanent cure is wind-dispelling, cold extermination, dissipates
The stasis of blood.
For this reason, it is necessary to research and develop with the low Chinese medicine preparation of wind-dispelling, cold extermination, heat radiation function, and toxic side effect.
The content of the invention
It is an object of the present invention to provide the Chinese medicine preparation and its extracting method that a kind of heat-clearing dissipates the stasis of blood.Chinese medicine system of the present invention
Agent is formed by 13 taste Chinese herbal medicine reasonable preparations, is complemented each other, and is had effects that blood-nourishing, is dissipated the stasis of blood, analgesic, cold-dispelling, is especially suitable for
In pain diseases such as treatment women common headache, rheumatalgia and dysmenorrhoeas, have specific aim high, safety is without side-effects, is worth pushing away
It is wide to use.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of heat-clearing dissipates the Chinese medicine preparation of the stasis of blood, is made of following raw material and parts by weight：Dragon-boat spends 11~23 parts, row
9~21 parts of vanilla, 8~24 parts of Strobilanthes aehobarbus W. W. Smith, 15~27 parts of naringi crenulata, 6~18 parts of sivery aleuritopteris herb, 8~24 parts of small hancock swallowwort herb, madder
5~25 parts of root, 10~30 parts of Samson St Johswort, 11~23 parts of purple back of the body grass, 12~24 parts of dichrocephala, 9~21 parts of auspicious Siberian cocklebur grass, conical silene herb 12
~20 parts, 8~16 parts of radix glycyrrhizae.
More preferably, a kind of heat-clearing dissipates the Chinese medicine preparation of the stasis of blood, is made of following raw material and parts by weight：Dragon-boat spends 14~
20 parts, 12~18 parts of Lysimachia capillipes Hemsl, 12~20 parts of Strobilanthes aehobarbus W. W. Smith, 18~24 parts of naringi crenulata, 9~15 parts of sivery aleuritopteris herb, small hancock swallowwort herb 12
~20 parts, 10~20 parts of madder, 15~25 parts of Samson St Johswort, 14~20 parts of purple back of the body grass, 15~21 parts of dichrocephala, auspicious Siberian cocklebur grass 12~
18 parts, 14~18 parts of conical silene herb, 10~14 parts of radix glycyrrhizae.
Optimally, a kind of heat-clearing dissipates the Chinese medicine preparation of the stasis of blood, is made of following raw material and parts by weight：Dragon-boat spends 17
Part, 15 parts of Lysimachia capillipes Hemsl, 16 parts of Strobilanthes aehobarbus W. W. Smith, 21 parts of naringi crenulata, 12 parts of sivery aleuritopteris herb, 16 parts of small hancock swallowwort herb, 15 parts of madder, ingot
20 parts of grass, 17 parts of purple back of the body grass, 18 parts of dichrocephala, 15 parts of auspicious Siberian cocklebur grass, 16 parts of conical silene herb, 12 parts of radix glycyrrhizae.
Further, present invention also offers the extracting method of above-mentioned formula, comprise the following steps：
(1) raw material preliminary drying：The raw medicinal material of whole components is weighed according to parts by weight；Raw material is cleaned after drying, chopping is extremely
Length is less than 1cm；Then raw medicinal material is placed in 35~50 DEG C of low temperature in baking oven and bakees 15~30min, insulation is spare；
(2) isothermal soaks：75%~85% ethanol solution is measured according to 6~8 times of component of raw medicinal material gross mass, will
Ethanol solution is preheated to 35~50 DEG C, and the raw medicinal material after the ethanol solution submergence after preheating is bakeed, continues at 35~50 DEG C
Water-bath in soak 40~60min；
(3) alcohol extracting：By the solidliquid mixture obtained by step (2), 80~120 DEG C, 1~5h of refluxing extraction are heated to, Gu
Liquid separates to obtain alcohol extract, and ethanol is recovered under reduced pressure, then is concentrated, dried, crushed, and obtains alcohol extracting thing dry powder；
(4) water extracts：By the dregs of a decoction obtained by step (3) separation of solid and liquid, the water of 3~5 times of its gross weight is added, 100~
160 DEG C of 2~3h of heating and refluxing extraction, separation of solid and liquid obtain aqueous extract, and aqueous extract is concentrated, dry, is crushed, and obtain water and carry
Take thing dry powder；
(5) major function composition is made：Water extract obtained by alcohol extracting thing dry powder obtained by step (3) and step (4) is done
Powder is uniformly mixed, and adds pharmaceutical excipients, pharmaceutical preparation is made.
Preferably, the dregs of a decoction after the alcohol extracting of the step (3) add ethanol again, and the process 1 of repeat step (3)~
2 times, the water abstraction process of step (4) is then carried out again.
Preferably, the water abstraction process of the step (4) repeats 1~2 time.
The Chinese medicine preparation can be prepared into powder, granule, tablet, pill, capsule or oral liquid.
The effect of each primary raw material medicine and effect are as follows in Chinese medicine preparation of the present invention：(1) dragon-boat is spent：Its bitter, micro-puckery, property
It is cool, there is dissipate stasis of blood hemostasis, antihypertensive effect, is mainly used for hemoptysis of pulmonary tuberculosis, and stomachache, rheumatic arthritis, traumatic injury, menstruation is not
Adjust, amenorrhoea, hypertension；(2) Lysimachia capillipes Hemsl：Its is sweet in flavor, mild-natured, has wind-dispelling, and cough-relieving, menstruation regulating effect, is mainly used for cold cough,
Tracheitis, asthma, irregular menstruation, neurasthenia；(3) Strobilanthes aehobarbus W. W. Smith：Its lightly seasoned, slight bitter, it is mild-natured, there is promoting blood circulation for regulating menstruation, clear liver
Hot merit is imitated, and cures mainly eye conjunctivitis, irregular menstruation, postpartum abdominal pain icteric hepatitis；(4) naringi crenulata：It is its bitter, salty, it is warm-natured, have
Promoting blood circulation, hemostasis, warming middle-JIAO and strengthening the spleen, strengthening by means of tonics effect are mainly used for irregular menstruation, functional uterine bleeding, hemorrhoid hemorrhage, and stomach is burst
Ulcer, insufficiency of the spleen edema；(5) sivery aleuritopteris herb：Its is lightly seasoned, mild-natured, has cough-relieving, menstruation regulating, and clearing damp effect cures mainly cough, and irregular menstruation is red
Under leukorrhea；(6) small hancock swallowwort herb：Its bitter, it is mild-natured, there is regulating menstruation, hemostasis, removing toxicity for detumescence effect, is mainly used for irregular menstruation, disappears
Change gastrointestinal hemorrhage, spit blood, bleeding from five sense organs or subcutaneous tissue；Traumatic hemorrhage, furuncle swelling toxin, venomous snake bite are controlled in external application；(7) madder：Its bitter, it is cold in nature, enter
The heart, Liver Channel.To stop blooding with promoting circulation of blood, clearing and activating the channels and collaterals, cough-relieving apophlegmatic effect, is chiefly used in controlling haematemesis, and bleeding from five sense organs or subcutaneous tissue, hematuria, has blood in stool, metrorrhagia,
Amenorrhea, arthralgia pain due to rheumatism, traumatic injury, the stagnant swelling and pain of the stasis of blood, jaundice, chronic bronchitis；(8) Samson St Johswort：Its acrid flavour, hardship, it is cold in nature, have
Clearing heat and detoxicating, clearing and activating the channels and collaterals, cooling blood and hemostasis effect, is mainly used for infantile hyperpyrexia, and dysentery, enteritis, spits blood, bleeding from five sense organs or subcutaneous tissue, irregular menstruation,
Leukorrhea；Traumatic hemorrhage, traumatic injury, mastitis, burn and scald, venomous snake bite are controlled in external application；(9) conical silene herb：Its bitter, cool in nature, tool
There is clearing heat and cooling blood, blood-arresting catamenia-regulating effect, is mainly used for nosebleed epistaxis, spits blood, hematuria, lung abscess, irregular menstruation；(10) auspicious Siberian cocklebur grass：Its
It is bitter, pungent, it is cool in nature, there is promoting blood circulation for regulating menstruation, heat-clearing improving eyesight effect.Cure mainly irregular menstruation, consumptive disease hectic fever due to yin, mesh disease；(11) dichrocephala：
It is its bitter, pungent, it is mild-natured, there is promoting blood circulation for regulating menstruation, removing toxicity for detumescence effect, is mainly used for irregular menstruation, sprains swelling and pain；Poisonous snake is controlled in external application
Bite, serious case of furuncle.
The beneficial effects of the invention are as follows：Medicine of the present invention is developed based on the obstructed mechanism for causing pain disease to occur of vim and vigour
A kind of compatibility for going out is reasonable, cold-dispelling dissipates the good Chinese herbal medicine formula of stasis of blood effect and its high efficiency extraction mode.The Chinese medicine preparation has
Preferable blood-nourishing dissipates the effect of stasis of blood pharmacological function, has good specific aim height, therapeutic effect, high efficiency, has no toxic side effect to human body
The advantages of.
Embodiment
Embodiment 1
A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood, is made of the raw material and parts by weight of following medicine：Dragon
Ship spend 11 parts, 9 parts of Lysimachia capillipes Hemsl, 8 parts of Strobilanthes aehobarbus W. W. Smith, 15 parts of naringi crenulata, 6 parts of sivery aleuritopteris herb, 8 parts of small hancock swallowwort herb, 5 parts of madder, member
Precious 10 parts of grass, 11 parts of purple back of the body grass, 12 parts of dichrocephala, 9 parts of auspicious Siberian cocklebur grass, 12 parts of conical silene herb, 8 parts of radix glycyrrhizae.
The Chinese medicine of the present embodiment follows the steps below：
(1) raw material preliminary drying：The raw medicinal material of whole components is weighed according to parts by weight；Raw material is cleaned after drying, chopping is extremely
Length is less than 1cm；Then raw medicinal material is placed in 35 DEG C of low temperature in baking oven and bakees 30min, insulation is spare；
(2) isothermal soaks：75% ethanol solution is measured according to 6 times of component of raw medicinal material gross mass, by ethanol solution
35 DEG C are preheated to, the raw medicinal material after the ethanol solution submergence after preheating is bakeed, continues to soak 40min in 35 DEG C of water-bath；
(3) alcohol extracting：
A) by step (2) obtained by solidliquid mixture, be heated to 80 DEG C, refluxing extraction 1h, separation of solid and liquid obtains alcohol extract,
Ethanol is recovered under reduced pressure, then is concentrated, dried, crushed, obtains an alcohol extracting thing dry powder；
B) toward 75% ethanol solution for adding 6 times of quality in the separating obtained dregs of a decoction again, repeat step a), obtains secondary
Alcohol extracting thing dry powder；
C) repeat step b), obtains alcohol extracting thing dry powder three times；
(4) water extracts：By the dregs of a decoction of the final gained of step (3), the water of 5 times of its gross weight is added, 125 DEG C are heated to reflux
2h is extracted, separation of solid and liquid obtains aqueous extract, aqueous extract is concentrated, dry, is crushed, and obtains water extract dry powder；
(5) major function composition is made：By an alcohol extracting thing dry powder, secondary alcohol extracting thing dry powder, three obtained by step (3)
Water extract dry powder blend obtained by secondary alcohol extracting thing dry powder and step (4) is uniform, you can.
Embodiment 2
A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood, is made of the raw material and parts by weight of following medicine：Dragon
Ship spend 14 parts, 12 parts of Lysimachia capillipes Hemsl, 12 parts of Strobilanthes aehobarbus W. W. Smith, 18 parts of naringi crenulata, 9 parts of sivery aleuritopteris herb, 12 parts of small hancock swallowwort herb, madder 10
Part, 15 parts of Samson St Johswort, 14 parts of purple back of the body grass, 15 parts of dichrocephala, 12 parts of auspicious Siberian cocklebur grass, 14 parts of conical silene herb, 10 parts of radix glycyrrhizae.
The Chinese medicine of the present embodiment follows the steps below：
(1) raw material preliminary drying：The raw medicinal material of whole components is weighed according to parts by weight；Raw material is cleaned after drying, chopping is extremely
Length is less than 1cm；Then raw medicinal material is placed in 50 DEG C of low temperature in baking oven and bakees 15min, insulation is spare；
(2) isothermal soaks：80% ethanol solution is measured according to 6.5 times of component of raw medicinal material gross mass, ethanol is molten
Liquid is preheated to 50 DEG C, and the raw medicinal material after the ethanol solution submergence after preheating is bakeed, continues to soak in 50 DEG C of water-bath
45min；
(3) alcohol extracting：By the solidliquid mixture obtained by step (2), 120 DEG C are heated to, refluxing extraction 5h, separation of solid and liquid obtains
Alcohol extract, is recovered under reduced pressure ethanol, then is concentrated, dried, crushed, and obtains alcohol extracting thing dry powder；
(4) water extracts：By the dregs of a decoction of the final gained of step (3), the water of 4 times of its gross weight is added, 140 DEG C are heated to reflux
3h is extracted, separation of solid and liquid obtains aqueous extract, aqueous extract is concentrated, dry, is crushed, and obtains a water extract dry powder；
(5) by the dregs of a decoction repeat step (4) of gained after separation, secondary water extract dry powder is obtained；
(6) major function composition is made：By alcohol extracting thing dry powder, step (4) water extract of gained obtained by step (3)
Secondary water extract dry powder blend is uniform obtained by dry powder, step (5), you can.
Embodiment 3
A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood, is made of the raw material and parts by weight of following medicine：Dragon
Ship spend 17 parts, 15 parts of Lysimachia capillipes Hemsl, 16 parts of Strobilanthes aehobarbus W. W. Smith, 21 parts of naringi crenulata, 12 parts of sivery aleuritopteris herb, 16 parts of small hancock swallowwort herb, madder 15
Part, 20 parts of Samson St Johswort, 17 parts of purple back of the body grass, 18 parts of dichrocephala, 15 parts of auspicious Siberian cocklebur grass, 16 parts of conical silene herb, 12 parts of radix glycyrrhizae.
The Chinese medicine of the present embodiment follows the steps below：
(1) raw material preliminary drying：The raw medicinal material of whole components is weighed according to parts by weight；Raw material is cleaned after drying, chopping is extremely
Length is less than 1cm；Then raw medicinal material is placed in 45 DEG C of low temperature in baking oven and bakees 30min, insulation is spare；
(2) isothermal soaks：80% ethanol solution is measured according to 6 times of component of raw medicinal material gross mass, by ethanol solution
45 DEG C are preheated to, the raw medicinal material after the ethanol solution submergence after preheating is bakeed, continues to soak 45min in 45 DEG C of water-bath；
(3) alcohol extracting：By the solidliquid mixture obtained by step (2), 100 DEG C, refluxing extraction 2.5h are heated to, separation of solid and liquid
Alcohol extract is obtained, ethanol is recovered under reduced pressure, then is concentrated, dried, crushed, obtains an alcohol extracting thing dry powder；
(4) the separating obtained dregs of a decoction of step (3) are added to 80% ethanol solution of its 7 times of quality, and repeat step again
(3) operation, obtains secondary alcohol extracting thing dry powder；
(5) water extracts：By the dregs of a decoction of the final gained of step (4), the water of 5 times of its gross weight is added, 120 DEG C are heated to reflux
3h is extracted, separation of solid and liquid obtains aqueous extract, aqueous extract is concentrated, dry, is crushed, and obtains a water extract dry powder；
(6) repeat step (5) operates, and obtains secondary water extract dry powder；
(7) major function composition is made：An alcohol extracting thing dry powder obtained by above-mentioned steps, secondary alcohol extracting thing are done
Powder, a water extract dry powder and secondary water extract dry powder blend are uniform, you can.
Embodiment 4
A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood, is made of the raw material and parts by weight of following medicine：Dragon
Ship spend 20 parts, 18 parts of Lysimachia capillipes Hemsl, 20 parts of Strobilanthes aehobarbus W. W. Smith, 24 parts of naringi crenulata, 15 parts of sivery aleuritopteris herb, 20 parts of small hancock swallowwort herb, madder 20
Part, 25 parts of Samson St Johswort, 20 parts of purple back of the body grass, 21 parts of dichrocephala, 18 parts of auspicious Siberian cocklebur grass, 18 parts of conical silene herb, 14 parts of radix glycyrrhizae.
The Chinese medicine of the present embodiment follows the steps below：
(1) raw material preliminary drying：The raw medicinal material of whole components is weighed according to parts by weight；Raw material is cleaned after drying, chopping is extremely
Length is less than 1cm；Then raw medicinal material is placed in 45 DEG C of low temperature in baking oven and bakees 25min, insulation is spare；
(2) isothermal soaks：75% ethanol solution is measured according to 7 times of component of raw medicinal material gross mass, by ethanol solution
45 DEG C are preheated to, the raw medicinal material after the ethanol solution submergence after preheating is bakeed, continues to soak 50min in 45 DEG C of water-bath；
(3) alcohol extracting：By the solidliquid mixture obtained by step (2), 90 DEG C are heated to, refluxing extraction 3h, separation of solid and liquid obtains
Alcohol extract, is recovered under reduced pressure ethanol, then is concentrated, dried, crushed, and obtains an alcohol extracting thing dry powder；
(4) the separating obtained dregs of a decoction of step (3) are added to 75% ethanol solution of its 7 times of quality, and repeat step again
(3) operation, obtains secondary alcohol extracting thing dry powder；
(5) water extracts：By the dregs of a decoction of the final gained of step (4), the water of 3 times of its gross weight is added, 100 DEG C are heated to reflux
3h is extracted, separation of solid and liquid obtains aqueous extract, aqueous extract is concentrated, dry, is crushed, and obtains a water extract dry powder；
(6) repeat step (5) operation twice, respectively obtains secondary water extract dry powder and three times water extract dry powder；
(7) major function composition is made：An alcohol extracting thing dry powder obtained by above-mentioned steps, secondary alcohol extracting thing are done
Powder, a water extract dry powder, secondary water extract dry powder and water extract dry powder blend is uniform three times, you can.
Embodiment 5
A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood, is made of the raw material and parts by weight of following medicine：Dragon
Ship spend 23 parts, 21 parts of Lysimachia capillipes Hemsl, 24 parts of Strobilanthes aehobarbus W. W. Smith, 27 parts of naringi crenulata, 18 parts of sivery aleuritopteris herb, 24 parts of small hancock swallowwort herb, madder 25
Part, 30 parts of Samson St Johswort, 23 parts of purple back of the body grass, 24 parts of dichrocephala, 21 parts of auspicious Siberian cocklebur grass, 20 parts of conical silene herb, 16 parts of radix glycyrrhizae.
The Chinese medicine of the present embodiment follows the steps below：
(1) raw material preliminary drying：The raw medicinal material of whole components is weighed according to parts by weight；Raw material is cleaned after drying, chopping is extremely
Length is less than 1cm；Then raw medicinal material is placed in 40 DEG C of low temperature in baking oven and bakees 20min, insulation is spare；
(2) isothermal soaks：85% ethanol solution is measured according to 8 times of component of raw medicinal material gross mass, by ethanol solution
40 DEG C are preheated to, the raw medicinal material after the ethanol solution submergence after preheating is bakeed, continues to soak 60min in 40 DEG C of water-bath；
(3) alcohol extracting：By the solidliquid mixture obtained by step (2), 100 DEG C are heated to, refluxing extraction 4h, separation of solid and liquid obtains
Alcohol extract, is recovered under reduced pressure ethanol, then is concentrated, dried, crushed, and obtains alcohol extracting thing dry powder；
(4) water extracts：By the dregs of a decoction of the final gained of step (4), the water of 4 times of its gross weight is added, 160 DEG C are heated to reflux
2.5h is extracted, separation of solid and liquid obtains aqueous extract, aqueous extract is concentrated, dry, is crushed, and obtains water extract dry powder；
(5) major function composition is made：By the alcohol extracting thing dry powder and water extract dry powder blend obtained by above-mentioned steps
Uniformly, you can.
Test example
By the mixed powder of the gained of embodiment 1~5, same component is taken, adds the auxiliary material of same sample ingredient and component, respectively
Particle electuary is made, and is taken respectively to the female patient for having dysmenorrhoea, antimigraine or treating rheumatic ostealgia, taking dose and method one
Cause, every group of patient receiving treatment's number is consistent, and curative effect is as follows：
Therapeutic effect of (1) 5 group of medicine to quality dysmenorrhoea patient：
The effect of medicament is made in embodiment 1：60% patient has obvious the effect of alleviating pain after persistently taking medicine 3 weeks；
The effect of medicament is made in embodiment 2：52% patient persistently take medicine 3 weeks after half a year in no longer there is dysmenorrhoea and show
As；
The effect of medicament is made in embodiment 3：64% patient persistently take medicine 3 weeks after 9 months in no longer there is dysmenorrhoea and show
As；
The effect of medicament is made in embodiment 4：58% patient persistently take medicine 3 weeks after 9 months in no longer there is dysmenorrhoea and show
As；
The effect of medicament is made in embodiment 5：48% patient has obvious the effect of alleviating pain after persistently taking medicine 3 weeks.
Therapeutic effect of (2) 5 groups of medicines to quality migraineur：
The effect of medicament is made in embodiment 1：42% patient has the obvious treatment for alleviating pain after persistently taking medicine 1 month
Effect；
The effect of medicament is made in embodiment 2：46% patient persistently take medicine 1 month after half a year in no longer there is antimigraine
Phenomenon；
The effect of medicament is made in embodiment 3：56% patient persistently take medicine 1 month after half a year in no longer there is antimigraine
Phenomenon；
The effect of medicament is made in embodiment 4：54% patient persistently take medicine 1 month after half a year in no longer there is antimigraine
Phenomenon；
The effect of medicament is made in embodiment 5：55% patient, which persistently took medicine in 1 month later six months, no longer to be there is antimigraine and shows
As.
Therapeutic effect of (3) 5 groups of medicines to quality treating rheumatic ostealgia patient：
The effect of medicament is made in embodiment 1：8% patient medication 2 weeks during and its rear 1 month rheumatoid disease ostalgia phenomenon
There is obvious alleviation；
The effect of medicament is made in embodiment 2：8.5% patient is during taking medicine 2 weeks and its rear 1 month rheumatoid disease ostalgia shows
As there is obvious alleviation；
The effect of medicament is made in embodiment 3：9.5% patient is in 1 month after medication 2 weeks without there is treating rheumatic ostealgia
Phenomenon；
The effect of medicament is made in embodiment 4：8.3% patient is in 1 month after medication 2 weeks without there is treating rheumatic ostealgia
Phenomenon；
The effect of medicament is made in embodiment 5：9.4% patient is in 1 month after medication 2 weeks without there is treating rheumatic ostealgia
Phenomenon.
Claims (6)
1. a kind of heat-clearing dissipates the Chinese medicine preparation of the stasis of blood, it is characterised in that is made of following raw material and parts by weight：Dragon-boat spends 11
~23 parts, 9~21 parts of Lysimachia capillipes Hemsl, 8~24 parts of Strobilanthes aehobarbus W. W. Smith, 15~27 parts of naringi crenulata, 6~18 parts of sivery aleuritopteris herb, small hancock swallowwort herb 8~
24 parts, 5~25 parts of madder, 10~30 parts of Samson St Johswort, 11~23 parts of purple back of the body grass, 12~24 parts of dichrocephala, auspicious Siberian cocklebur grass 9~21
Part, 12~20 parts of conical silene herb, 8~16 parts of radix glycyrrhizae.
2. a kind of heat-clearing as claimed in claim 1 dissipates the Chinese medicine preparation of the stasis of blood, it is characterised in that is by following raw material and parts by weight
Array into：Dragon-boat spend 14~20 parts, 12~18 parts of Lysimachia capillipes Hemsl, 12~20 parts of Strobilanthes aehobarbus W. W. Smith, 18~24 parts of naringi crenulata, sivery aleuritopteris herb
9~15 parts, 12~20 parts of small hancock swallowwort herb, 10~20 parts of madder, 15~25 parts of Samson St Johswort, 14~20 parts of purple back of the body grass, dichrocephala
15~21 parts, 12~18 parts of auspicious Siberian cocklebur grass, 14~18 parts of conical silene herb, 10~14 parts of radix glycyrrhizae.
3. a kind of heat-clearing dissipates the extracting method of the Chinese medicine preparation of the stasis of blood, it is characterised in that comprises the following steps：
(1) raw material preliminary drying：The raw medicinal material of whole components is weighed according to parts by weight；Raw material is cleaned after drying, shredded to length
Less than 1cm；Then raw medicinal material is placed in 35~50 DEG C of low temperature in baking oven and bakees 15~30min, insulation is spare；
(2) isothermal soaks：75%~85% ethanol solution is measured according to 6~8 times of component of raw medicinal material gross mass, by ethanol
Solution is preheated to 35~50 DEG C, and the raw medicinal material after the ethanol solution submergence after preheating is bakeed, continues the water at 35~50 DEG C
40~60min is soaked in bath；
(3) alcohol extracting：By the solidliquid mixture obtained by step (2), 80~120 DEG C, 1~5h of refluxing extraction are heated to, solid-liquid point
From alcohol extract is obtained, ethanol is recovered under reduced pressure, then is concentrated, dried, crushed, obtains alcohol extracting thing dry powder；
(4) water extracts：By the dregs of a decoction obtained by step (3) separation of solid and liquid, the water of 3~5 times of its gross weight is added, 100~160 DEG C
2~3h of heating and refluxing extraction, separation of solid and liquid obtain aqueous extract, and aqueous extract is concentrated, dry, is crushed, obtains water extract
Dry powder；
(5) major function composition is made：Water extract dry powder obtained by alcohol extracting thing dry powder obtained by step (3) and step (4) is mixed
Close uniformly, add pharmaceutical excipients, pharmaceutical preparation is made.
4. a kind of heat-clearing as claimed in claim 3 dissipates the extracting method of the Chinese medicine preparation of the stasis of blood, it is characterised in that：The step
(3) the dregs of a decoction after alcohol extracting add ethanol again, and the process of repeat step (3) 1~2 time, then carry out step (4) again
Water abstraction process.
5. a kind of heat-clearing as claimed in claim 3 dissipates the extracting method of the Chinese medicine preparation of the stasis of blood, it is characterised in that：The step
(4) water abstraction process repeats 1~2 time.
6. a kind of heat-clearing as claimed in claim 3 dissipates the extracting method of the Chinese medicine preparation of the stasis of blood, it is characterised in that：The mixing of gained
Powder is used to prepare into powder, granule, tablet, pill, capsule or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711493366.7A CN107982334A (en) | 2017-12-30 | 2017-12-30 | A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711493366.7A CN107982334A (en) | 2017-12-30 | 2017-12-30 | A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107982334A true CN107982334A (en) | 2018-05-04 |
Family
ID=62040560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711493366.7A Pending CN107982334A (en) | 2017-12-30 | 2017-12-30 | A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107982334A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600333A (en) * | 2003-09-28 | 2005-03-30 | 钟厚尧 | Painkiller |
-
2017
- 2017-12-30 CN CN201711493366.7A patent/CN107982334A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600333A (en) * | 2003-09-28 | 2005-03-30 | 钟厚尧 | Painkiller |
Non-Patent Citations (1)
| Title |
|---|
| 李明等: "《中华本草》收载止痛中药药性规律研究", 《山东中医药大学学报》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102198219B (en) | Chinese medicine for treating woman puerperal fever and preparation method thereof | |
| CN105687824A (en) | Traditional Chinese medicine granules for treating postpartum night sweat and preparation method | |
| CN105168650A (en) | Traditional Chinese medicinal composition for anesthesia and analgesia for operations of general surgery | |
| CN115837058A (en) | Traditional Chinese medicine composition, preparation thereof and application of traditional Chinese medicine composition in medicine for treating diabetic peripheral neuropathy | |
| CN101874850A (en) | Medicament for treating chronic urticaria | |
| CN107982334A (en) | A kind of heat-clearing dissipates the Chinese medicine preparation and its extracting method of the stasis of blood | |
| CN106361932A (en) | Externally-applied traditional Chinese medicine tincture for traumatic injury | |
| CN100571732C (en) | The urticarial Chinese medicine decoction of a kind of treatment | |
| CN104840874A (en) | Traditional Chinese medicine pills used for aneurysm postoperative rehabilitation treatment and preparation method thereof | |
| CN104096023A (en) | Medicine composition for nursing scoliosis and preparation method thereof | |
| CN103860990B (en) | Coronary heart disease promoting blood circulation to remove obstruction in the collateral powder and preparation method | |
| CN103041036B (en) | Pill for treating prosopalgia | |
| CN102512601A (en) | Traditional Chinese medicine recipe for treating rheumatoid arthritis | |
| CN105456368A (en) | Pill for dispelling wind and eliminating dampness and preparing method thereof | |
| CN105434662A (en) | Traditional Chinese medicine preparation for treating aphthous ulcer | |
| CN103845671A (en) | Powder for treating heart failure by warming yang and tonifying qi and preparation method thereof | |
| CN104225094A (en) | Traditional Chinese medicine preparation for treating Behcet's syndrome | |
| CN105688074A (en) | Decoction medicine for treating hypogastric pain and preparation method of decoction medicine | |
| CN104825892A (en) | Traditional Chinese medicine preparation for treating ovulatory bleeding and preparation method of traditional Chinese medicine preparation | |
| CN105343785A (en) | Traditional Chinese medicine pills for treating vertebrobasilar insufficiency (VBI) and preparation method thereof | |
| CN104666819A (en) | Chinese medicine bath with effects of clearing liver-heat and regulating menstruation | |
| CN103720870A (en) | Traditional Chinese medicament preparation for treating myocarditis and preparation method thereof | |
| CN107875363A (en) | A kind of medicine for being used to treat preceded menstural cycle | |
| CN108126158A (en) | It is a kind of treat just, the decoction medicine of migraine and preparation method thereof | |
| CN109381539A (en) | A kind of capsule preparations for treating rheumatism heat type neurodermatitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180504 |
|
| WD01 | Invention patent application deemed withdrawn after publication |