CN105343785A - Traditional Chinese medicine pills for treating vertebrobasilar insufficiency (VBI) and preparation method thereof - Google Patents
Traditional Chinese medicine pills for treating vertebrobasilar insufficiency (VBI) and preparation method thereof Download PDFInfo
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- CN105343785A CN105343785A CN201510869605.9A CN201510869605A CN105343785A CN 105343785 A CN105343785 A CN 105343785A CN 201510869605 A CN201510869605 A CN 201510869605A CN 105343785 A CN105343785 A CN 105343785A
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Abstract
The invention discloses traditional Chinese medicine pills for treating vertebrobasilar insufficiency (VBI) and a preparation method thereof and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine pills comprise the following effective ingredients used as raw materials: root of ficus erecta, lotus leaves, the fruit of Chinese wolfberry, bamboo shavings, rust-coloured crotalaria herb with root, ganoderma lucidum, alectoria asiatica Du Rietz, longan pulp, goodyera schlechtendaliana, polygonatum odoratum, fructus corni, herb and root of tetrastigma obtectum, root of piitosporum glabraium, peach kernels, carthamus tinctorius, sarcopyramis nepalensis, gynostemma pentaphyllum, cortex acanthopanacis, radix glycyrrhizae, tribulus terrestris, rhizoma curcumae, aspongopus, antelope's horn and benzoin. According to the invention, the medicinal materials are selected according to disease causes and the traditional Chinese medicine pills have the efficacies of nourishing the liver and kidney, invigorating qi and blood, warming the middle, reinforcing yang, promoting blood circulation to remove blood stasis, suppressing hyperactive liver for calming endogenous wind, clearing heat, eliminating phlegm, promoting qi, promoting blood circulation, activating blood and dredging collaterals, are simple and convenient to take, good in absorbing effect and obvious in curative effect, and have no toxic or side effects, and no adverse clinical reaction, and through clinical verification, the cure rate of the traditional Chinese medicine pills disclosed by the invention is relatively high for the vertebrobasilar insufficiency.
Description
Art
The present invention relates to the field of Chinese medicines, particularly relate to the medicine pill and preparation method that are used for the treatment of vertebral-basilar artery insufficiency.
Background technology
Vertebral-basilar artery insufficiency (vertebrobasilarinsuffi-ciencyVBI) is that the Vertebral-basilar artery that causes due to the various cause of disease is narrow or inaccessible and cause the ischemia of brain stem, cerebellum or occipital ctx.Vertebro-basilar artery insufficiency is common clinical disease, is common in middle-aged and elderly people.The generation of this disease is mostly because arteriosclerosis or prolapse of cervical intervertebral disc, loose vascular compression, have impact on blood circulation, cause brain blood flow not smooth, blood supply insufficiency, patient can occur dizzy, nausea and vomiting, walking is unstable, limb tremor, or blurred vision, or eyes vibration, the symptoms such as dysphonia.
Doctor trained in Western medicine often according to the different causes of disease, adopts different remedy measures for primary disease.As atherosclerosis class patient can adopt anticoagulant (as aspirin enteric-coated dose), blood vessel expander (dextran), cerebral vasodilator and albumin optical photon therapy etc., the feasible cervical traction of hyperosteogeny of cervical vertebra class patient, wherein modal is atherosclerosis class patient, in general, acute attack stage should select Western medicine preparation to treat, can the quick control state of an illness, quick result, but course for the treatment of convalescent period is longer, life-time service western medicine easily produces drug resistance, and there is certain side effect, and western medicine is generally injection, need carry out intravenous drip to hospital every day, very large inconvenience is brought to the life of patient, therefore convalescent period uses Chinese medicine to carry out rehabilitation usually, cost is few, time saving and energy saving, and it is evident in efficacy.
Primary disease belongs to the category such as the traditional Chinese medical science " dizzy ", " card of fainting ".Its pathogenesis is normal with blood deficiency stasis, and press from both sides on expectorant and disturb, mechanism of qi is obstructed relevant.Therefore the primary disease traditional Chinese medical science is adopted usually to the Therapeutic Method of benefiting QI for activating blood circulation, clearing and dissipating phlegm-heat, temperature three-way meridian.As publication No. CN101612216A (application number: Chinese patent literature 200810055259.0) discloses the application of a kind of Chinese medicine composition in the medicine of preparation treatment vertebral-basilar artery insufficiency, this Chinese medicine composition is made up of Radix Ginseng, Hirudo, Scolopendra, Scorpio, Eupolyphaga Seu Steleophaga, Periostracum Cicadae, Radix Paeoniae Rubra, Borneolum Syntheticum etc., has effect of benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral.The present invention sums up through long-term clinical practice, thinks that primary disease case core is blood stasis, and treatment should based on blood circulation and channel invigorating, and primary disease is mainly in middle-aged and elderly people simultaneously, and how because of its physical weakness, YANG QI deficiency, can not warmly gasify, promote blood, disorder of movement of QI, thus hematogenous blockage, YANG-orifices failing to be nourished, causes primary disease, and therefore the present invention is according to the cause of disease, suits the remedy to the case, and has nourishing the liver nourishing kidney, benefiting vital QI and blood, warming middle-JIAO is supporing yang, blood circulation promoting and blood stasis dispelling, suppressing the hyperactive liver to relieve the wind syndrome, removing heat-phlegm, promoting flow of QI and blood, effect of promoting blood circulation to remove obstruction in the collateral, proves to have energy blood vessel dilating wall containing multiple through modern medicine study in selected medical material in side, reduces whole blood viscosity, increase blood flow volume, blood sugar lowering, blood fat reducing, alleviate the Chinese medicine that atherosclerotic plaque forms effect, as Ganoderma in side obviously can reduce cholesterolemia, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque, for atherosclerotic plaque former, then have and reduce Arterial Cholesterol content, vessel softening, prevent the effect of damage further, Fructus Lycii in side, Fructus Corni, Rhizoma Curcumae Longae, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae can immunity moderation, blood sugar lowering, blood fat reducing, in side, Folium Nelumbinis has expansible blood vessel, blood fat reducing, has efficacy in lowering high blood pressure, in side, Flos Carthami is improved human body immune function, blood pressure lowering, blood fat reducing, increase coronary flow and the multiple pharmacological effect such as myocardial alimentary blood flow, inhibition thrombosis, in side, Cortex Acanthopancis has the effect reducing whole blood viscosity, atherosclerosis formation, in side, in Semen Persicae, contained Semen Persicae alcohol extract can increase vein blood vessel flow, vasodilator, can increase femoral artery blood flow, reduces vascular resistance, has direct dilating effect to blood vessel wall, also has in addition and suppresses blood coagulation and haemolysis, the effect that the Fructus Tribuli saponin that in side, Fructus Atriplicis Sibiricae can be contained has coronary artery dilator, improves coronary artery circulation, strengthens cardiac contractile force, anticoagulant, in side, Rhizoma Polygonati Odorati has the effect of blood sugar lowering, blood fat reducing, the formation of alleviation atherosclerotic plaque, in side, all medicines share, and effectively can improve patient's vertebral-basilar artery blood supply situation, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to vertebral-basilar artery insufficiency cure rate through clinical verification.
Summary of the invention
The invention provides the medicine pill and preparation method that are used for the treatment of vertebral-basilar artery insufficiency, there is nourishing the liver nourishing kidney, benefiting vital QI and blood, warming middle-JIAO be supporing yang, effect of blood circulation promoting and blood stasis dispelling, suppressing the hyperactive liver to relieve the wind syndrome, removing heat-phlegm, promoting flow of QI and blood, promoting blood circulation to remove obstruction in the collateral, cure the disease and ask source treating both the principal and secondary aspects of a disease, to the multiple vertebral-basilar artery insufficiency that a variety of causes causes, all there is good curative effect.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Be used for the treatment of the medicine pill of vertebral-basilar artery insufficiency, raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Be used for the treatment of the preparation method of the medicine pill of vertebral-basilar artery insufficiency, comprise following processing step:
(1) by Radix Fici beecheyanae, Folium Nelumbinis, Fructus Lycii, Caulis Bambusae In Taenia, Herba Crotalariae Ferrugineae, Ganoderma, Alectoria asiatica Du Rietz, Rhizoma Polygonati Odorati, Flos Carthami, Herba Sarcopyramis nepalensis, Herb Gynostemmae Pentaphylli, Rhizoma Curcumae Longae, Radix Glycyrrhizae mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;
(2) Arillus Longan, Herba goodyearae repentis, Herba Seu Radix Tetrastigmatis Obtecti, Radix Pittospori Glabrati, Semen Persicae are put into container, add the shao-hsing rice wine of 3 ~ 5 times amount, cool after boiling, continue immersion 3 ~ 4 hours, get immersion; In remaining medicinal residues, add the shao-hsing rice wine of 2 ~ 3 times amount again, put after boiling and dry in the air, continue immersion 2 ~ 3 hours, get immersion; Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.15 ~ 1.25, for subsequent use;
(3) get clean Fructus Corni, mix thoroughly with yellow wine, put into sealed container, put in kettle, water proof heats, and stew and exhaust to wine, take out, dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(4) slender acanthopanax skin graft and yellow wine are mixed thoroughly, when moistening is most to wine, takes out, dry, put in parch container, heat fried dry with slow fire, taking-up is dried in the air cool, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(5) remove the Fructus Atriplicis Sibiricae of thorn, mix thoroughly with saline, vexed, put in pot and fry to micro-yellow with slow fire, take out, dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(6) getting clean Aspongopus puts in pot, and with slow fire heating, fry to when having fragrance to overflow, take out, cool, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(7) dry clean for Cornu Saigae Tataricae, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(8) Benzoinum pulverizing is ground into powder, cross 120 order dusting covers, obtain fine powder, for subsequent use;
(9) by the thick paste of step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), step (7), step (8), add after refined honey stirs, be prepared as the pill of every 3g.
The property of medicine of the present invention's Chinese medicine used is as follows:
Radix Fici beecheyanae: sweet in the mouth; Pungent; Warm in nature.Return lung; Spleen; Kidney channel.Replenishing QI to invigorate the spleen; Promoting blood circulation to remove obstruction in the collateral; Expelling wind and removing dampness.Cure mainly overstrain weak; Lack of appetite; Agalactia; Insufficiency of the spleen leucorrhea; Proctoptosis; Menoxenia; Wind syndrome of head pain; Traumatic injury; Rheumatic arthralgia." east, Fujian book on Chinese herbal medicine ": invigorating the spleen and replenishing QI, invigorating the spleen for eliminating dampness, bone and muscle strengthening, detumescence, promoting blood circulation and detoxication.Control the middle deficiency of vital energy weak, QI and blood is on the decline, and extremity are aching and limp, stiffness of the muscle and joint, amenorrhea, galactostasis.
Folium Nelumbinis: bitter in the mouth is pungent, micro-puckery, cool in nature.GUIXIN, liver, spleen channel.Delicate fragrance rises loose; There is summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, effect of dissipating blood stasis hemostasis.Cure mainly summer-heat excessive thirst, have a headache dizzy, edema, lack of appetite abdominal distention, dysentery, leucorrhea, proctoptosis, spit blood, epistaxis, spitting of blood, has blood in stool, metrorrhagia, post partum longtime lochia, traumatic blood stasis.Modern study result shows, Folium Nelumbinis has effect for reducing blood fat.Nuciferine is the alkaloid extracted in Folium Nelumbinis, the expansible blood vessel of nuciferine, and clearing away summer-heat, has the effect of blood pressure lowering, the good medicine of still fat-reducing simultaneously.
Fructus Lycii: sweet in the mouth; Property is put down.Return liver; Kidney; Lung meridian.Nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual one clear; Soreness of the waist and knees; The expensive essence of sexual impotence; Cough due to consumptive disease; To quench one's thirst taking fluids profusely." book on Chinese herbal medicine just " carries: " improve visual and auditory acuity, adds the solid marrow of essence, strengthen the muscle and bone, and kind benefit impairment caused by overstrain, especially only quenches one's thirst." modern medicine study confirm, Fructus Lycii scalable body's immunity, can effectively Tumor suppression grow and cell mutation, there is the effect of the aspect such as slow down aging, anti-fatty liver, adjusting blood lipid and blood glucose, promotion hemopoietic function.
Caulis Bambusae In Taenia: sweet in the mouth; Cold nature.Return spleen; Stomach; Gallbladder meridian.Removing heat-phlegm; Relieve restlessness and prevent vomiting; Antiabortive removing heat from blood.Cure mainly cough due to lung-heat; Dysphoria with smothery sensation is palpitated with fear; Gastric heat is vomitted oh; Pregnancy reactions; Frequent fetal movement; Spit blood; Epistaxis; Hematuria; Metrorrhagia." book on Chinese herbal medicine is new again ": pathogenic fire purging relieving restlessness, lung moistening dissipating depression of QI, reduce phlegm removing heat from blood, emesis blood, Removing Blood Stasis, eliminating carbuncle flaccidity toxic swelling.
Herba Crotalariae Ferrugineae: the micro-acid of bitter in the mouth; Property flat cold.Return lung meridian.Nourishing the kidney and liver, relieving cough and asthma, eliminating damp, detoxifying.Cure mainly tinnitus, deaf, the vertigo, seminal emission, menorrhagia, leucorrhea, chronic cough expectorant blood, asthma, nephritis, dysuria, tonsillitis, parotitis, furuncle swelling toxin." vegetation is side just ": invigorating the spleen and replenishing QI, treat tinnitus, the head is giddy, collapses pouring.Pathogenic fire purging heat clearing away again, suppressing liver-wind, detumescence pain.
Ganoderma: sweet-bitter flavor, property are flat, return lung; The heart; Spleen; Kidney channel.Replenishing QI and blood; Tranquilizing mind; Strengthening the spleen and stomach.Cure mainly: asthenia; Cardiopalmus; Insomnia; Dizzy; Spiritlessness and weakness; Chronic cough is panted; Coronary heart disease; Pneumosilicosis; Tumor.Shennong's Herbal: " Ganoderma lucidum (Leyss. Ex Fr.) Karst., bitter in the mouth is put down.Master ties in the heart, the beneficial motive, invigorating middle warmer, increases intelligence, does not forget.Modern medicine study finds, Ganoderma can coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; to myocardial ischemia, there is protective effect, treatment and the prevention of coronary heart diseases and angina pectoris etc. can be widely used in.To high fat of blood patient, Ganoderma can obviously reduce cholesterolemia, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque.For atherosclerotic plaque former, then there are reduction Arterial Cholesterol content, vessel softening, prevent the effect of damage further.
Alectoria asiatica Du Rietz: lightly seasoned; Property is put down.Return liver; Kidney; Urinary bladder channel.Nourishing the kidney and liver; Arresting seminal emission hidroschesis; Inducing diuresis to remove edema; Removing dampness sore.Cure mainly kidney deficiency and bodily weakness; The vertigo; Cardiopalmus; Seminal emission; Night sweat; Stranguria; Edema; Impetigo.
Arillus Longan: sweet in the mouth; Warm in nature.Enter the heart; Kidney; Liver; Spleen channel.Reinforcing the heart spleen; Replenishing QI and blood; Tranquilizing mind.Cure mainly the palpitation with fear caused by deficiency of both the heart and spleen, insufficiency of vital energy and blood; Palpitation with a distress feeling; Insomnia; Forgetful; Blood deficiency and yellow complexion; Menoxenia; Metrorrhagia." must join book on Chinese herbal medicine " carries: " strengthening the spleen stomach, preserve painstaking effort, moistening five ZANG-organs, controls palpitation with a distress feeling." modern medicine study confirmation, Arillus Longan is stimulated by low temperature, high temperature and anoxia to be had significant protective effect to cardiac muscle, has inhibitory action to Microsporon audouini, also has calm and digestion promoting function in addition.
Herba goodyearae repentis: sweet in the mouth; Pungent; Property is put down.Nourishing the lung to arrest cough; Tonify Qi of the kidney; Promoting flow of QI and blood; Subduing swelling and detoxicating.Cure mainly pulmonary tuberculosis cough; Tracheitis; Dizzy weak; Neurasthenia; Sexual impotence; Traumatic injury; Arthralgia; Laryngopharynx swelling and pain; Acute mastitis; Furuncle; Scrofula; Venom." Chinese herbal medicine is commonly used in Tibet ": hard masses softening and resolving.Control scrofula.
Rhizoma Polygonati Odorati: sweet in the mouth; Cold nature.Return lung; Stomach warp.Nourishing YIN to relieve dryness; Promoting the production of body fluid to quench thirst.Cure mainly syndrome of deficiency of lung yin; Deficiency of YIN fire is scorching; Hemoptysis; Dry pharynx; Aphonia; The dry the moon that injures one's stomach; Dry mouth and tougue; Inappetence; Dysphoria with smothery sensation hyperhidrosis; Palpitation with fear." book on Chinese herbal medicine justice " carries: " except unhappy, quench the thirst, profit cardiopulmonary, mend five kinds of strain and seven kinds of impairment deficient, and control lung dryness of the stomach heat, body fluid dries up, thirsty dry sensation in the pharynx, excessiveness of stomach-fire, dry thirsty rapid digestion of food." modern medicine study shows, Rhizoma Polygonati Odorati has enhancing antibody to generate, and improves phagocytic percentage and the phagocytic index of macrophage; promote interferon synthesis; suppress growth of bacillus tubercle, blood sugar lowering, blood fat reducing; alleviate atherosclerotic plaque and formed; make external perihaemal canal and coronary dilation, extend hypoxia endurance time, heart tonifying; antioxidation, the anti-ageing effect of waiting for a long time.
Fructus Corni: sour in the mouth; Slightly warm in nature, returns liver; Kidney channel.Liver and kidney tonifying; Convergence is solid de-, cures mainly: waist is had a dizzy spell; Deafness and tinnitus; Soreness of the waist and knees; Xian essence spermatorrhea; Frequent micturition; Incessant sweating due to debility; Woman uterine bleeding." Elementary Medicine ": this astringent of Fructus Corni also, how can lead to and send out heresy? covering all diseases is all bottom deficiency and coldness, the tonic Liver and kidney of use, and with Yi Qiyuan, then the five internal organs Amway, only, the meaning of the light dredging of Fei Ruota medicine also for the logical and sharp person of the person of closing.Modern medicine study shows: Fructus Corni has antibacterial, immunity moderation, blood sugar lowering, blood fat reducing, antioxidation, anticancer, the function such as anti-AIDS, heart tonifying.
Herba Seu Radix Tetrastigmatis Obtecti: acrid in the mouth; Warm in nature.Return liver; Spleen; Kidney channel.Expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.Cure mainly rheumatic arthralgia; Traumatic injury; Multiple abscess sucutaneous nodule; Carbuncle pyogenic infections from tumour or sore; Venom." Traditional Chinese Medicine in Sichuan will ": disperse rheumatism, promoting the circulation of blood intestinal stasis relieving.Control headache, general pain, bones and muscles pain, rheumatic numbness and multiple abscess; Sore is washed in external.
Radix Pittospori Glabrati: bitter in the mouth; Pungent; Slightly warm in nature.GUIXIN, kidney channel.Expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Cough-relieving arresting seminal emission.Cure mainly rheumatic arthralgia; Lumbago and skelalgia; Injury and bone fracture; Dizzy insomnia; Cough due to consumptive disease; Seminal emission." GUIHAIA register ": dispelling, collateral-activating, subduing swelling and detoxicating, promoting blood circulation and stopping pain.Treating rheumatic arthritis, injury and bone fracture, puerperal, paralysis, had a stomachache, venom, furuncle toxic swelling.
Semen Persicae: bitter in the mouth; Sweet; Property is put down.GUIXIN; Liver; Large intestine channel.Blood circulation promoting and blood stasis dispelling; Loosening bowel to relieve constipation; Relieving cough and asthma.Cure mainly amenorrhea; Dysmenorrhea; WEIJIA mass in the abdomen; Injury from falling down; Dryness of the intestine constipation." herbal classic is met former " carries: " Semen Persicae is the special medicine that blood stasis blood closes.Bitter to let out stagnant blood, sweetly control invasion of the blood-chamber by heat with tissue regeneration promoting blood, the stasis of blood amasss lump in the abdomen, amenorrhea, malaria with splenomegaly, cardiac and abdominal pain, also the blood agglomeration of loose Liver Channel." modern medicine study confirmation, Semen Persicae alcohol extract can increase vein blood vessel flow, vasodilator; can increase femoral artery blood flow, reduces vascular resistance, has direct dilating effect to blood vessel wall; maintain body temperature and protection internal organs, suppress blood coagulation and haemolysis in addition in addition.
Flos Carthami: acrid in the mouth; Warm in nature.Enter liver; Kidney channel.Promoting blood circulation to restore menstrual flow, scattered silt pain relieving.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." Guizhou medical herbs " carries: " heat-clearing and toxic substances removing, controls innominate toxic swelling, fracture." modern medicine study confirmation, Flos Carthami is improved human body immune function, blood pressure lowering, blood fat reducing, increase coronary flow and the multiple pharmacological effect such as myocardial alimentary blood flow, inhibition thrombosis.
Herba Sarcopyramis nepalensis: bitter in the mouth; Sweet; Cold nature.Return lung; Liver Channel.Heat clearing away suppressing the hyperactive liver; Eliminating damp, detoxifying.Cure mainly cough due to lung-heat; The vertigo; Tinnitus; Deaf; Day red photophobia; Hepatitis; Rheumatic arthralgia; Traumatic injury wound is swollen; Snake head-like infection; Innominate toxic swelling." Traditional Chinese Medicine in Sichuan will ": clearing away lung-heat, liver-fire of dispelling, dispelling the wind and dampness pathogens arthralgia pain, tinnitus, deafness and order mist photophobia.
Herb Gynostemmae Pentaphylli: bitter in the mouth; Micro-sweet; Cool in nature.Return lung; Spleen; Kidney channel.To nourish heart spleen invigorating, QI invigorating and blood regulating, heat-clearing and toxic substances removing, blood stasis dispelling of eliminating the phlegm.Cure mainly: body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.Record in " the little book series of bright clear TCM Clinical ": Herb Gynostemmae Pentaphylli boosting qi and nourishing yin, removing heat from the lung and dissipating phlegm, tranquilizing by nourishing the heart, spermatogenesis controlling nocturnal emission with astringent drugs.Modern medicine study finds, Herb Gynostemmae Pentaphylli principle active component is polysaccharide, flavonoid, saponins and microelement kind, its effect mainly promotes body fat class substance metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (pharyngolaryngitis, gastroenteritis etc.) and health care.
Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature.Return liver, kidney channel.Wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; To invigorate blood circulation arteries and veins.Main anemofrigid-damp arthralgia; Lumbocrural pain; Muscles and bones flaccidity is soft; The decimal a little walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination is itched." book on Chinese herbal medicine is new again ": eliminating phlegm and removing dampness, supports kidney benefit essence, removes emaciation due to emotional upset water, and reason beriberi lumbago, controls all poison of skin ulcer scabies.Modern study proves, this product has the effects such as antitumor, resisting fatigue, reduction whole blood viscosity, atherosclerosis formation.
Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; Stomach warp.Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.Compendium of Material Medica is carried: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine and gains merit." modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, have anti-gastric-ulcer, gastritis effect in addition.
Fructus Atriplicis Sibiricae: bitter in the mouth; Pungent; Property is put down.Enter liver; Lung; Kidney; Heart channel.Suppressing the hyperactive liver; Resolving depression; Dispelling pathogenic wind for improving eyesight.Cure mainly headache; Dizzy; Distending pain in the chest and hypochondrium; Distending pain of the breast; Breast closes obstructed; Amenorrhea; Cataract; Rubella pruritus; Vitiligo; Skin ulcer cellulitis; Scrofula." book on Chinese herbal medicine is just read " carries: " benefaction is kind broken, specially enters lung, liver, lung qi dispersing stagnant, soothing the liver silt, therefore can control migratory arthralgia order disease." modern medicine study shows; the effect that the Fructus Tribuli saponin contained by Fructus Atriplicis Sibiricae has coronary artery dilator, improves coronary artery circulation, strengthens cardiac contractile force, decreasing heart rate; also can anticoagulant; the ischemic electrocardiographic change that prevention pituitrin and isoproterenol bring out; allevating angina pectoris; improve myocardial ischemia, has resisting myocardial ischemia and reduces the effect of myocardial infarct size.
Rhizoma Curcumae Longae: bitter in the mouth; Pungent; Warm in nature.Return spleen; Liver Channel.Removing blood stasis circulation of qi promoting; Inducing menstruation to relieve menalgia.Cure mainly all cards of stagnation of QI and blood; Born of the same parents' abdomen hypochondriac pain; Dysmenorrhes; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Rheumatic arthralgia; Traumatic injury; Carbuncle." Bencao Jingshu ": Rhizoma Curcumae Longae, its taste bitter flavor prevailing over pungent flavor is bad, and Xin Xiang is dry strong, and property should not be trembled with fear., hardship can expel the heat-evil, pungent energy eliminating stagnation, therefore main trusted subordinate ties long-pending genus blood system person.Doublely can control gas, therefore the cloud therapeutic method to keep the adverse QI flowing downwards again.Its arduous power total, removing blood stasis is except wind heat, and subduing inflammation, its what one is particularly good at also." solar corona " is called it and can be controlled mass in the abdomen clot, again logical menstruation and flutter damage blood stasis, and Su Song calls it and eliminating evilly wards off evil, control flatulence and puerperal deteriorated blood make a psychological attack, what is it possible that therapeutic method to keep the adverse QI flowing downwards removing blood stasis pungent walk the merit Yu that lets out of hardship.Examine its aroma therapy, be situated between RHZOMA SPARGANII, Radix Curcumae medicine also.Modern medicine study proves: Rhizoma Curcumae Longae has the effect of blood fat reducing, antitumor, function of gallbladder promoting, antiinflammatory, and has influence to cardiovascular system.
Aspongopus: salty in the mouth; Warm in nature.Return through liver; Kidney; Spleen channel.Regulating QI to relieve pain, warming middle-JIAO is supporing yang.For cold syndrome of the stomach distending pain, stomachache due to hyperactive liver-QI attacking the stomach, impotence due to deficiency of the kidney, soreness of waist and knee joint." detailed outline ": control the stagnant gas of diaphragm gastral cavity, spleen-kidney deficiency, kidney-Yang invigorating.Modern medicine study proves: Aspongopus has stronger antibacterial action to staphylococcus aureus, Bacillus typhi, Salmonella paratyphi, shigella flexneri; And have promotion body metabolism.
Cornu Saigae Tataricae: salty in the mouth; Cold in nature.Return liver; Heart channel.Suppressing the hyperactive liver to relieve the wind syndrome; Liver heat removing and eyesight improving; Removing pathogenic heat from blood and toxic substance from the body.Cure mainly liver-wind stirring up internally infantile convulsion to twitch; The contracture of muscle arteries and veins; Liver-yang headache is dizzy; Liver-fire conjunctival congestion and swelling pain and heat in blood hemorrhage; Epidemic febrile disease sends out speckle; Carbuncle sore tumefacting virus." book on Chinese herbal medicine is new again ": centering god, only night sweat, consumer edema, blood stasis removing blood, tissue regeneration promoting blood, the pathogenic fire reducing therapeutic method to keep the adverse QI flowing downwards, relieving restlessness of quenching the thirst.Modern medicine study proves: Cornu Saigae Tataricae has calmness, analgesia, antipyretic and anticonvulsant action, and has certain effect to blood circulation tool.
Benzoinum: acrid in the mouth; Bitter; Property is put down.GUIXIN; Liver; Spleen channel.To have one's ideas straightened out refreshment; Eliminating phlegm is warded off dirty; Promoting flow of QI and blood; Pain relieving.Cure mainly middle wind-phlegm Jue; Infantile convulsion is gone into a coma, puerperal blood faints; Trusted subordinate's pain; Migratory arthralgia arthrodynia of the extremities." Bencao Congxin ": should qi and blood circulation promotion.Grind and take the promoting the circulation of blood therapeutic method to keep the adverse QI flowing downwards, calm the nerves.Modern medicine study proves: benzoic tincture is stimulant expectorant, and Benzoinum still has antisepsis in addition.
The present invention compared with prior art, has following beneficial effect:
The present invention selects medical material, the property of medicine is suitable mutually auxiliary mutually, suit the remedy to the case for the cause of disease, have nourishing the liver nourishing kidney, benefiting vital QI and blood, warming middle-JIAO be supporing yang, effect of blood circulation promoting and blood stasis dispelling, suppressing the hyperactive liver to relieve the wind syndrome, removing heat-phlegm, promoting flow of QI and blood, promoting blood circulation to remove obstruction in the collateral, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to vertebral-basilar artery insufficiency cure rate through clinical verification.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and weight are:
The processing step of process for preparing medicine of the present invention is:
(1) by Radix Fici beecheyanae, Folium Nelumbinis, Fructus Lycii, Caulis Bambusae In Taenia, Herba Crotalariae Ferrugineae, Ganoderma, Alectoria asiatica Du Rietz, Rhizoma Polygonati Odorati, Flos Carthami, Herba Sarcopyramis nepalensis, Herb Gynostemmae Pentaphylli, Rhizoma Curcumae Longae, Radix Glycyrrhizae mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;
(2) Arillus Longan, Herba goodyearae repentis, Herba Seu Radix Tetrastigmatis Obtecti, Radix Pittospori Glabrati, Semen Persicae are put into container, add the shao-hsing rice wine of 3 ~ 5 times amount, cool after boiling, continue immersion 3 ~ 4 hours, get immersion; In remaining medicinal residues, add the shao-hsing rice wine of 2 ~ 3 times amount again, put after boiling and dry in the air, continue immersion 2 ~ 3 hours, get immersion; Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.15 ~ 1.25, for subsequent use;
(3) get clean Fructus Corni, mix thoroughly with yellow wine, put into sealed container, put in kettle, water proof heats, and stew and exhaust to wine, take out, dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(4) slender acanthopanax skin graft and yellow wine are mixed thoroughly, when moistening is most to wine, takes out, dry, put in parch container, heat fried dry with slow fire, taking-up is dried in the air cool, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(5) remove the Fructus Atriplicis Sibiricae of thorn, mix thoroughly with saline, vexed, put in pot and fry to micro-yellow with slow fire, take out, dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(6) getting clean Aspongopus puts in pot, and with slow fire heating, fry to when having fragrance to overflow, take out, cool, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(7) dry clean for Cornu Saigae Tataricae, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(8) Benzoinum pulverizing is ground into powder, cross 120 order dusting covers, obtain fine powder, for subsequent use;
(9) by the thick paste of step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), step (7), step (8), add after refined honey stirs, be prepared as the pill of every 3g.
Usage and dosage:
Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection
The routine clinical observation of vertebral-basilar artery insufficiency patient 40 selecting my institute to make a definite diagnosis, wherein male 22 example, women 18 example, 44 ~ 73 years old age, 57.6 years old mean age, the shortest person of the course of disease 3 months, most elder 5 years, average 1.8 years.
2, Therapeutic Method
Patient takes medicine of the present invention, oral, each 2 of every day 3 times, and one hour ante cibum, with warm water delivery service, 30 days was 1 course for the treatment of, took 1 course for the treatment of.
3, observational technique
Before and after treatment, routine biochemistry detects blood fat (TG, TC, HDL-C, LDL-C), blood glucose (Glu), hemorheology index (whole blood viscosity, plasma viscosity, Fibrinogen);
Before and after treatment, TCD detects and observes basilar artery (BA) and bilateral vertebral artery (VA) blood flow state, records the peak velocity (Vs) of each tremulous pulse, mean flow rate (Vm), pulsatility index (PI).
4, efficacy determination
(1) cure: clinical symptom disappearance, TCD checks that vertebral-basilar artery blood supply is normal.
(2) take a turn for the better: clinical symptoms is obviously alleviated, TCD checks that vertebral-basilar artery blood supply obviously improves.
(3) invalid: symptom is with treating front no significant difference.
5, model case
(1) grandson's ××, man, 57 years old.Patient occasionally has the symptoms such as dizzy, myasthenia of limbs, eyes tremble, feel sick, and comes institute and goes to a doctor, be diagnosed as vertebral-basilar artery insufficiency on inspection, after taking 1 course for the treatment of of medicine of the present invention, clinical symptom disappearance, TCD checks that vertebral-basilar artery blood supply is normal, fully recovers.
(2) king's ××, female, 64 years old.When patient's getting up early is brushed teeth, burst headrest portion pain, very dizzy, astasia, nausea and vomiting subsequently, headache and dizzyly feel to alleviate after vomiting, comes institute and goes to a doctor, be diagnosed as vertebral-basilar artery insufficiency on inspection, after taking 1 course for the treatment of of medicine of the present invention, clinical symptom disappearance, TCD checks that vertebral-basilar artery blood supply is normal, fully recovers.
6, therapeutic outcome
Rear clinical treatment outcome treated by table 1
From table 1, cure 23 examples, take a turn for the better 14 examples, and total effective rate 92.5%, medicine of the present invention has good curative effect to vertebral-basilar artery insufficiency.
Front and back blood fat treated by table 2, blood glucose target compares (mmol/L)
From table 2, after treatment, patients with lipid, blood glucose condition obviously improve, and reduce atherosclerotic generation, reach the object for the treatment of vertebral-basilar artery blood supply.
Table 3 is treated front and back hemorheology index and is compared
From table 3, after treatment, hemorheology situation is obviously improved, and before treatment compared by blood viscosity, numerical value diminishes to some extent, and blood fluidity improves thereupon, effectively decreases the thrombosis causing vertebral-basilar artery insufficiency disease to produce.
Table 4 is treated front and back TCD testing result and is compared
From table 4, after treatment, VA, BA blood circulation makes moderate progress, and brain blood supply is sufficient, decreases the dizzy clinical symptoms of vertebral-basilar artery insufficiency that waits and occurs.
In sum, medicine of the present invention sums up configuration through long-term clinical practice to form, suit the remedy to the case according to the cause of disease, there is nourishing the liver nourishing kidney, benefiting vital QI and blood, warming middle-JIAO be supporing yang, effect of blood circulation promoting and blood stasis dispelling, suppressing the hyperactive liver to relieve the wind syndrome, removing heat-phlegm, promoting flow of QI and blood, promoting blood circulation to remove obstruction in the collateral, to vertebral-basilar artery insufficiency, there is good curative effect.Simultaneously according to modern medicine vertebral-basilar artery insufficiency etiological study, in side, selected medical material proves to have energy blood vessel dilating wall containing multiple through modern medicine study, reduce whole blood viscosity, increase blood flow volume, blood sugar lowering, blood fat reducing, alleviate the Chinese medicine that atherosclerotic plaque forms effect, as Ganoderma in side can obviously reduce cholesterolemia, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque, for atherosclerotic plaque former, then there are reduction Arterial Cholesterol content, vessel softening, prevent the effect of damage further; Fructus Lycii in side, Fructus Corni, Rhizoma Curcumae Longae, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae can immunity moderation, blood sugar lowering, blood fat reducing; Folium Nelumbinis has expansible blood vessel, blood fat reducing, has efficacy in lowering high blood pressure; In side, Flos Carthami is improved human body immune function, blood pressure lowering, blood fat reducing, increase coronary flow and the multiple pharmacological effect such as myocardial alimentary blood flow, inhibition thrombosis; In side, Cortex Acanthopancis has the effect reducing whole blood viscosity, atherosclerosis formation; In side, in Semen Persicae, contained Semen Persicae alcohol extract can increase vein blood vessel flow, vasodilator, can increase femoral artery blood flow, reduces vascular resistance, has direct dilating effect to blood vessel wall, also has in addition and suppresses blood coagulation and haemolysis; The effect that the Fructus Tribuli saponin that in side, Fructus Atriplicis Sibiricae can be contained has coronary artery dilator, improves coronary artery circulation, strengthens cardiac contractile force, anticoagulant; In side, Rhizoma Polygonati Odorati has the effect of blood sugar lowering, blood fat reducing, the formation of alleviation atherosclerotic plaque; In side, all medicines share, and effectively can improve patient's vertebral-basilar artery blood supply situation, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to vertebral-basilar artery insufficiency cure rate through clinical verification.
Claims (4)
1. be used for the treatment of the medicine pill of vertebral-basilar artery insufficiency, it is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:
2. the medicine pill being used for the treatment of vertebral-basilar artery insufficiency according to claim 1, is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:
3. the medicine pill being used for the treatment of vertebral-basilar artery insufficiency according to claim 1, is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:
4. be used for the treatment of the preparation method of the medicine pill of vertebral-basilar artery insufficiency, it is characterized in that, comprise following processing step:
(1) by Radix Fici beecheyanae, Folium Nelumbinis, Fructus Lycii, Caulis Bambusae In Taenia, Herba Crotalariae Ferrugineae, Ganoderma, Alectoria asiatica Du Rietz, Rhizoma Polygonati Odorati, Flos Carthami, Herba Sarcopyramis nepalensis, Herb Gynostemmae Pentaphylli, Rhizoma Curcumae Longae, Radix Glycyrrhizae mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;
(2) Arillus Longan, Herba goodyearae repentis, Herba Seu Radix Tetrastigmatis Obtecti, Radix Pittospori Glabrati, Semen Persicae are put into container, add the shao-hsing rice wine of 3 ~ 5 times amount, cool after boiling, continue immersion 3 ~ 4 hours, get immersion; In remaining medicinal residues, add the shao-hsing rice wine of 2 ~ 3 times amount again, put after boiling and dry in the air, continue immersion 2 ~ 3 hours, get immersion; Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.15 ~ 1.25, for subsequent use;
(3) get clean Fructus Corni, mix thoroughly with yellow wine, put into sealed container, put in kettle, water proof heats, and stew and exhaust to wine, take out, dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(4) slender acanthopanax skin graft and yellow wine are mixed thoroughly, when moistening is most to wine, takes out, dry, put in parch container, heat fried dry with slow fire, taking-up is dried in the air cool, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(5) remove the Fructus Atriplicis Sibiricae of thorn, mix thoroughly with saline, vexed, put in pot and fry to micro-yellow with slow fire, take out, dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(6) getting clean Aspongopus puts in pot, and with slow fire heating, fry to when having fragrance to overflow, take out, cool, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(7) dry clean for Cornu Saigae Tataricae, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;
(8) Benzoinum pulverizing is ground into powder, cross 120 order dusting covers, obtain fine powder, for subsequent use;
(9) by the thick paste of step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), step (7), step (8), add after refined honey stirs, be prepared as the pill of every 3g.
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Cited By (1)
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| CN102671005A (en) * | 2012-05-31 | 2012-09-19 | 郑文婧 | Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia |
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| CN105617349A (en) * | 2016-04-01 | 2016-06-01 | 青岛智信天成科技发展有限公司 | Traditional Chinese medicine pill for preventing and treating altitude stress and preparation method thereof |
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Application publication date: 20160224 |