CN109331133A - Treat the Chinese medicine composition of migraine, the preparation method of pharmaceutical preparation and oral solution - Google Patents
Treat the Chinese medicine composition of migraine, the preparation method of pharmaceutical preparation and oral solution Download PDFInfo
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- CN109331133A CN109331133A CN201811590949.6A CN201811590949A CN109331133A CN 109331133 A CN109331133 A CN 109331133A CN 201811590949 A CN201811590949 A CN 201811590949A CN 109331133 A CN109331133 A CN 109331133A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses the preparation methods of the Chinese medicine composition for the treatment of migraine, pharmaceutical preparation and oral solution.Chinese medicine composition is made of 15~20g of smilax, 10~20g of honeysuckle, 8~12g of radix saposhnikoviae, 12~16g of Rhizoma Chuanxiong, 5~10g of the flower bud of lily magnolia, 20~25g of young tea leaves, 6~10g of Rhizoma Gastrodiae, 6~12g of Jing Zi.Pharmaceutical preparation includes above-mentioned Chinese medicine composition, dosage form is the preparation method step of oral solution are as follows: Chinese medicine composition is added in water and is heated, first time extracting solution is obtained by filtration in boiling certain time, filter residue plus water are heated, second of extracting solution is obtained by filtration in boiling certain time, will be mixed to get mixed extract by extracting solution twice；Mixed extract is heated, is filtered after ten minutes wait boil, filtrate is dispensed with 15ml bottle, oral solution is made.Chinese medicine composition produced by the present invention is easy to that absorption, quick, good effect, price is low and has no toxic side effect.
Description
Technical field
The present invention relates to the preparation methods of the Chinese medicine composition for the treatment of migraine, pharmaceutical preparation and oral solution, belong to Chinese medicine neck
Domain.
Background technique
Migraine is clinically common one of headache type, and Chinese medicine is commonly called as " migraine ", and doctor trained in Western medicine claims vascular headache.It is main
If causing because entocranial artery shrinks or expands, it can also be bilatenal headache that about 2/3 has a headache for side property.This disease is not with tendency
Migraine it is most commonly seen: ictal moderate to severe pulsation or persistent headache, head side or bilateral distending pain, frequently send out
Make, with Nausea and vomiting or photophobia.Migraine has the specific normal clearance phase, and headache continues 4~72 hours, after sleep often
See alleviation.
In current existing technology, western medical treatment this disease is palliative often based on sedation-analgesia, and Western medicine pair
Stomach is irritating, can generate undesirable side effect.
Summary of the invention
In view of the above-mentioned problems in the prior art, the present invention provides Chinese medicine composition, pharmaceutical preparation and the mouths for the treatment of migraine
Take the preparation method of liquid.
Technical solution is as follows:
A kind of Chinese medicine composition for treating migraine, by 15~20g of smilax, 10~20g of honeysuckle, radix saposhnikoviae 8~12g, river
12~16g of rhizome of chuanxiong, 5~10g of the flower bud of lily magnolia, 20~25g of young tea leaves, 6~10g of Rhizoma Gastrodiae, 6~12g of Jing Zi composition.
Further, the Chinese medicine composition is by smilax 20g, honeysuckle 15g, radix saposhnikoviae 10g, Rhizoma Chuanxiong 15g, flower bud of lily magnolia 7.5g, bud
Tea 25g, Rhizoma Gastrodiae 10g, Jing Zi 10g composition.
Further, the Chinese medicine composition is by smilax 18g, honeysuckle 16g, radix saposhnikoviae 8g, Rhizoma Chuanxiong 16g, flower bud of lily magnolia 10g, young tea leaves
24g, Rhizoma Gastrodiae 8g, Jing Zi 12g composition.
Further, the Chinese medicine composition is by smilax 16g, honeysuckle 20g, radix saposhnikoviae 9g, Rhizoma Chuanxiong 12g, flower bud of lily magnolia 6g, young tea leaves
22g, Rhizoma Gastrodiae 6g, Jing Zi 8g composition.
A kind of pharmaceutical preparation for treating migraine, which is characterized in that the Chinese medicine group including any of the above-described treatment migraine
Close object.
Further, the dosage form of said medicine preparation be capsule, tablet, powder, oral solution, pill, tincture, syrup,
Suppository, gelling agent, spray or injection.
The raw material for preparing of a kind of preparation method of oral solution that treating migraine, the oral solution includes that any of the above-described is controlled
The Chinese medicine composition of migraine is treated, the oral solution is made of following steps:
A) smilax after weighing, honeysuckle, radix saposhnikoviae, Rhizoma Chuanxiong, the flower bud of lily magnolia, young tea leaves, Rhizoma Gastrodiae, Jing Zi are added to 6~8 times of Chinese medicines
It is heated in the water of total weight, wait boil after twenty minutes, first time extracting solution is obtained by filtration, 4~6 times of Chinese medicine gross weights are added to filter residue
The water of amount is heated, and after boiling 15 minutes, second of extracting solution is obtained by filtration, and extracting solution will be mixed to get mixing twice and be mentioned
Take liquid；
B) mixed extract described in a) is heated, is filtered after ten minutes wait boil, by filtrate 15ml bottle point
It fills and oral solution is made.
Pharmacological action:
Smilax: removing toxic substances, dehumidifying is easing joint movement.
Honeysuckle: also known as honeysuckle, have the function of antibacterial, antiviral, inhibition ulcer, enhancing immune function.
Radix saposhnikoviae: expelling pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion.
Rhizoma Chuanxiong: promote breath and open depression, it is wet to dispel wind-dryness, promoting blood circulation and stopping pain.
The flower bud of lily magnolia: expelling cold, eliminating, clearing the nasal passage.
Young tea leaves: heat-clearing and fire-reducing helps digestion and refreshes oneself.
Rhizoma Gastrodiae: relieve the wind syndrome, arresting convulsion.
Jing Zi: antidiarrheal dysentery.
The utility model has the advantages that Chinese medicine composition produced by the present invention is easy to, absorption, quick, good effect, price be low and nontoxic pair
Effect.
Specific embodiment
Below by specific embodiment, invention is further described in detail.But those skilled in the art will manage
Solution, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.Based on the implementation in the present invention
Example, every other embodiment obtained by those of ordinary skill in the art without making creative efforts belong to
The scope of protection of the invention.
Embodiment one:
A kind of Chinese medicine composition for treating migraine, the Chinese medicine composition by smilax 20g, honeysuckle 15g, radix saposhnikoviae 10g,
Rhizoma Chuanxiong 15g, flower bud of lily magnolia 7.5g, young tea leaves 25g, Rhizoma Gastrodiae 10g, Jing Zi 10g composition.
Embodiment two:
A kind of Chinese medicine composition for treating migraine, the Chinese medicine composition by smilax 18g, honeysuckle 16g, radix saposhnikoviae 8g,
Rhizoma Chuanxiong 16g, flower bud of lily magnolia 10g, young tea leaves 24g, Rhizoma Gastrodiae 8g, Jing Zi 12g composition.
Embodiment three:
A kind of Chinese medicine composition for treating migraine, the Chinese medicine composition by smilax 16g, honeysuckle 20g, radix saposhnikoviae 9g,
Rhizoma Chuanxiong 12g, flower bud of lily magnolia 6g, young tea leaves 22g, Rhizoma Gastrodiae 6g, Jing Zi 8g composition.
Example IV:
A kind of oral solution for treating migraine is prepared, the Chinese medicine composition that raw material is embodiment one, preparation side are prepared
Steps are as follows for method:
A) after weighing by smilax 20g, honeysuckle 15g, radix saposhnikoviae 10g, Rhizoma Chuanxiong 15g, flower bud of lily magnolia 7.5g, young tea leaves 25g, Rhizoma Gastrodiae
10g, Jing Zi 10g are added in 700g water and heat, and wait boil after twenty minutes, first time extracting solution is obtained by filtration, and add to filter residue
560g water is heated, and after boiling 15 minutes, second of extracting solution is obtained by filtration, and extracting solution will be mixed to get mixing twice and be mentioned
Take liquid；
B) mixed extract described in a) is heated, is filtered after ten minutes wait boil, by filtrate 15ml bottle point
It fills and oral solution is made.
Embodiment five: Chinese medicine composition clinical test of the invention.
1, subjects: the patient for 50 migraine that the age is 22-55 years old.
2, test method: taking oral solution made from example IV, and twice daily, one bottle of oral solution 30 days is
One course for the treatment of.
3, test result: 50 follow-up of patients 3 months, wherein 30 patients fully recover (cure rate 60%), and 18 patients are good
Turn obvious (significant improvement rate 36%), remaining 2 patients are without obvious curative effects (inefficiency 4%).
4, typical examination example: Mr. Wang, male, 47 years old, the frequent cephalic pain of patient was eaten based on forehead and left side sun area
It crosses many Chinese and Western medicines and is showed no effect.After taking one course for the treatment of of oral solution of Chinese medicine composition of the invention, patient's headache obviously subtracts
Gently, symptom is gradually alleviated, and using the after treatment of two courses for the treatment of, clinical symptoms are completely disappeared, and there has been no recurrence since follow-up.
Claims (8)
1. a kind of Chinese medicine composition for treating migraine, which is characterized in that the Chinese medicine composition of the treatment migraine is by native Fu
15~20g of Siberian cocklebur, 10~20g of honeysuckle, 8~12g of radix saposhnikoviae, 12~16g of Rhizoma Chuanxiong, 5~10g of the flower bud of lily magnolia, 20~25g of young tea leaves, Rhizoma Gastrodiae 6~
6~12g of 10g, Jing Zi composition.
2. a kind of Chinese medicine composition for treating migraine according to claim 1, which is characterized in that the treatment migraine
Chinese medicine composition by smilax 20g, honeysuckle 15g, radix saposhnikoviae 10g, Rhizoma Chuanxiong 15g, flower bud of lily magnolia 7.5g, young tea leaves 25g, Rhizoma Gastrodiae 10g, Jing Zi
10g composition.
3. a kind of Chinese medicine composition for treating migraine according to claim 1, which is characterized in that the treatment migraine
Chinese medicine composition by smilax 18g, honeysuckle 16g, radix saposhnikoviae 8g, Rhizoma Chuanxiong 16g, flower bud of lily magnolia 10g, young tea leaves 24g, Rhizoma Gastrodiae 8g, Jing Zi 12g
Composition.
4. a kind of Chinese medicine composition for treating migraine according to claim 1, which is characterized in that the treatment migraine
Chinese medicine composition by smilax 16g, honeysuckle 20g, radix saposhnikoviae 9g, Rhizoma Chuanxiong 12g, flower bud of lily magnolia 6g, young tea leaves 22g, Rhizoma Gastrodiae 6g, Jing Zi 8g group
At.
5. a kind of pharmaceutical preparation for treating migraine, which is characterized in that including any one of Claims 1 to 4 inclined head for the treatment of
The Chinese medicine composition of pain.
6. the pharmaceutical preparation for the treatment of migraine according to claim 5, which is characterized in that the drug of the treatment migraine
The dosage form of preparation is capsule, tablet, powder, oral solution, pill, tincture, syrup, suppository, gelling agent, spray or injection
Agent.
7. a kind of preparation method for the oral solution for treating migraine, which is characterized in that the raw material for preparing of the oral solution includes power
Benefit requires the Chinese medicine composition of any one of 1~4 treatment migraine, and the oral solution is made of following steps:
A) smilax after weighing, honeysuckle, radix saposhnikoviae, Rhizoma Chuanxiong, the flower bud of lily magnolia, young tea leaves, Rhizoma Gastrodiae, Jing Zi are added to 6~8 times of Chinese medicine gross weights
It is heated in the water of amount, wait boil after twenty minutes, first time extracting solution is obtained by filtration, 4~6 times of Chinese medicine total weights are added to filter residue
Water is heated, and after boiling 15 minutes, second of extracting solution is obtained by filtration, and will be mixed to get mixing extraction by extracting solution twice
Liquid；
B) mixed extract described in a) is heated, is filtered after ten minutes wait boil, filtrate is dispensed with 15ml bottle and is made
Obtain oral solution.
8. as the described in any item Chinese medicine compositions of Claims 1 to 4 are preparing the application in the drug for treating migraine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811590949.6A CN109331133A (en) | 2018-12-25 | 2018-12-25 | Treat the Chinese medicine composition of migraine, the preparation method of pharmaceutical preparation and oral solution |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811590949.6A CN109331133A (en) | 2018-12-25 | 2018-12-25 | Treat the Chinese medicine composition of migraine, the preparation method of pharmaceutical preparation and oral solution |
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| Publication Number | Publication Date |
|---|---|
| CN109331133A true CN109331133A (en) | 2019-02-15 |
Family
ID=65297157
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|---|---|---|---|
| CN201811590949.6A Pending CN109331133A (en) | 2018-12-25 | 2018-12-25 | Treat the Chinese medicine composition of migraine, the preparation method of pharmaceutical preparation and oral solution |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1134829A (en) * | 1995-05-04 | 1996-11-06 | 杨伟蓬 | Granule for curing dizziness and headache |
| CN1600333A (en) * | 2003-09-28 | 2005-03-30 | 钟厚尧 | Painkiller |
| CN103751570A (en) * | 2014-02-13 | 2014-04-30 | 王怀方 | Orally taken traditional Chinese medicine for treating migraine |
| CN105596791A (en) * | 2015-11-20 | 2016-05-25 | 王亚芳 | Traditional Chinese medicine composition for treating migraine and preparation method thereof |
-
2018
- 2018-12-25 CN CN201811590949.6A patent/CN109331133A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1134829A (en) * | 1995-05-04 | 1996-11-06 | 杨伟蓬 | Granule for curing dizziness and headache |
| CN1600333A (en) * | 2003-09-28 | 2005-03-30 | 钟厚尧 | Painkiller |
| CN103751570A (en) * | 2014-02-13 | 2014-04-30 | 王怀方 | Orally taken traditional Chinese medicine for treating migraine |
| CN105596791A (en) * | 2015-11-20 | 2016-05-25 | 王亚芳 | Traditional Chinese medicine composition for treating migraine and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 师磊等: "盐酸氟桂利嗪通天口服液并用治疗偏头痛120例", 《实用中医内科杂志》 * |
| 徐新刚等: "头痛立愈胶囊质量标准研究", 《中成药》 * |
| 朱世鹏: "《朱新太针灸经验集 朱氏针法传承》", 31 January 2017, 中国中医药出版社 * |
| 王良信: "《中医高效偏方验方4000首》", 30 June 2015, 中国医药科技出版社 * |
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