CN103585206B - A kind of preparation method of Chrysosplenium extract and application thereof - Google Patents
A kind of preparation method of Chrysosplenium extract and application thereof Download PDFInfo
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Abstract
The present invention relates to a kind of preparation method and application thereof of Chrysosplenium extract, belong to field of medicaments.Its preparation method take Chrysosplenium nudicaule Bunge as raw material, after extracting, obtained, comprise Chrysosplenium extract A, Chrysosplenium extract B by twice purification with macroreticular resin by different concentration ethanol.This Chrysosplenium extract, can combine with pharmaceutically acceptable carrier or other proper excipient, conventionally make the dosage form of oral administration.Chrysosplenium extract of the present invention can be used for preparation treatment acute cholecystitis medicine.
Description
Technical field
The invention belongs to biomedicine field, relate to a kind of preparation method and application thereof of Chinese medicinal material extract, specifically relate to a kind of preparation method of Chrysosplenium extract and the application in preparation treatment acute cholecystitis medicine thereof.
Background technology
Cholecystitis is the gallbladder inflammatory lesion that bacterial infection or chemical irritation (bile component change) cause, and is the commonly encountered diseases of gallbladder.In abdominal surgery, its sickness rate is only second to appendicitis, and primary disease is more common in the middle age of 35 ~ 55 years old, and the women comparatively male that falls ill for many, is more common in obesity and the women of multiple pregnancies especially.Relax clinical performance according to the urgency of morbidity and can be divided into acute and chronic two classes, all belong to biliary infection category.The symptom of acute cholecystitis, mainly contains upper right abdomen pain, Nausea and vomiting and heating etc.Acute cholecystitis can cause right Upper abdominal pain, at the beginning pain and biliary colic closely similar, but its time continued of the stomachache that causes of acute cholecystitis is often longer, breathes and change position usually to make pain increase the weight of, therefore patient likes reposing to the right more, to alleviate abdomen pain.Some patient has nausea and vomiting, but vomiting is general inviolent.Most patient is also with heating, and body temperature is usually between 38.0 DEG C ~ 38.5 DEG C, and Gao Re is actually rare with shiver with cold.A few patients also has the white of the eye and skin slightly to turn to be yellow.When doctor checks the abdominal part of patient, can find that right upper quadrant of the abdomen has tenderness, and have tension of abdominal muscle, the gallbladder of enlargement can also be touched greatly in the patient of 1/3.The blood of chemical examination patient, can find the numeration of leukocyte in most human blood and neutrophilia.Ultrasound diagnosis can find gollbladder dilation, cyst wall thickens, and visible calculus gets lodged in the cervical region of gallbladder.According to above symptom, physical examination and various auxiliary examination, doctor generally can make the diagnosis of acute cholecystitis in time.
Western medical treatment divides expectant treatment and operative treatment.Expectant treatment is to lie up, and strengthen nutrition, the intravenous drip of medicine many employings antibiotics, indometacin is oral, though achieve the good effect of short-term, easily repeatedly; Operative treatment is excision cholecystitis, but the mortality rate 0.5-3% of operative therapy, jaundice case mortality is 10-15%, and gerontal case mortality rate is up to 13.5-16%, and operation intercurrent disease is about 15%.Therefore operative therapy as treatment cholecystitis basic therapy be unsafty.The Chinese medicine of current treatment cholecystitis mainly contains, Decoction of Gentiana for Purging the Liver-fire, depressed liver-energy dispersing and function of gallbladder promoting soup, soothing liver-QI Stomach-Regulating Decoction, stomach invigorating circulation of qi promoting soup, XIAOYAN LIDAN PIAN, depressed liver-energy dispersing and function of gallbladder promoting cream, clearing gallbladder circulation of qi promoting soup, clearing away heat-damp and promoting diuresis soup, clearing gallbladder pathogenic fire purging soup, bupleurum root decoction, tarragon soup adjust that five a kind of reed mentioned in ancient books are loose, Herba Artemisiae Scopariae and CHENGQI TANG, Daxianxiong Tang etc., although these medicines have certain curative effect, but still can not be satisfactory.
Chrysosplenium nudicaule Bunge is saxifragaceae plant Chrysasplenium nudicaule Chrysosplenium nudicaule Bge. and the dry herb belonging to several plants together.Autumn gathers, and removing dead leaf, cleans, dry.Record in " Drug Standard of Ministry of Public Health of the Peoples Republic of China Tibetan medicine (first) ", standard number: WS3-BC-0061-95.Cold in nature, bitter in the mouth.There is clearing heat secreting bile, cathartic purgation effect.For gallbladder-heat disease, fever, headache, cholecystitis, cholelithiasis.For rushing down gallbladder-heat disease common drug.The common drug of the minority areas such as illiteracy is hidden for China.But about the basic research of Chrysosplenium nudicaule Bunge is still very limited, the follow-up promotion and application of this medical material are restricted.Modern study rarely has report about the chemical composition of Herba of Artemisiae admsii and pharmacological action.
Domestic patent search result, has no Chrysosplenium nudicaule Bunge Patents.
Above-mentioned document and patent etc., there is not yet the relevant report of Chrysosplenium extract preparation method and the application in preparation treatment acute cholecystitis medicine thereof.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of Chrysosplenium extract and and treat the application in acute cholecystitis medicine in preparation.
The present invention is achieved through the following technical solutions:
The present invention is raw materials used: Chrysosplenium nudicaule Bunge is little saxifragaceae plant Chrysasplenium nudicaule Chrysosplenium nudicaule Bge. and the dry herb belonging to several plants together.
the present inventionthe preparation method of Chrysosplenium extract and the application in preparation treatment acute cholecystitis medicine thereof, described Chrysosplenium extract preparation method is:
(1) Chrysosplenium nudicaule Bunge, soaks 4-12 hour, adopts extraction by steam distillation volatile oil, extraction time 1-4 hour, extraction time 1-3 time, and amount of water is 8-15 times of Chrysosplenium nudicaule Bunge weight, collects volatile oil, obtains Chrysosplenium extract A; Chrysosplenium nudicaule Bunge aqueous extract is filtered, obtains medicinal liquid A and medicinal residues A respectively;
(2) step (1) being obtained medicinal residues A concentration 50%-95% ethanol is solvent, heating and refluxing extraction, extraction time is 1-3 time, each extraction time is 1-3 hour, and each solvent load is 8-15 times of Chrysosplenium nudicaule Bunge weight, filters, extracting solution reclaims ethanol, concentrated, dry, obtain Chrysosplenium extract B;
(3) by the medicinal liquid A that step (1) obtains, be concentrated into relative density d=1.10-1.20, filter, medicinal liquid, by nonpolar macroporous adsorption resin, first washes with water, and water elution liquid is directly by polar macroporous resin; Use the alcoholic solution eluting nonpolar macroporous adsorption resin of concentration 30%-70% again, collect different concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract C; Use the alcoholic solution eluting polar macroporous adsorption resin of concentration 50%-95% again, collect different concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract D;
(4) by above-mentioned Chrysosplenium extract A, Chrysosplenium extract B, Chrysosplenium extract C, Chrysosplenium extract D, wherein one or both or three kinds or four kinds mix by a certain percentage, obtain Chrysosplenium extract of the present invention.
A kind of Chrysosplenium extract preparation method is:
(1) Chrysosplenium nudicaule Bunge, soaks 4-12 hour, adopts extraction by steam distillation volatile oil, extraction time 1-4 hour, extraction time 1-3 time, and amount of water is 8-15 times of Chrysosplenium nudicaule Bunge weight, collects volatile oil, obtains Chrysosplenium extract A; Chrysosplenium nudicaule Bunge aqueous extract is filtered, obtains medicinal liquid A and medicinal residues A respectively;
(2) step (1) being obtained medicinal residues A concentration 50%-95% ethanol is solvent, heating and refluxing extraction, extraction time is 1-3 time, each extraction time is 1-3 hour, and each solvent load is 8-15 times of Chrysosplenium nudicaule Bunge weight, filters, extracting solution reclaims ethanol, concentrated, dry, obtain Chrysosplenium extract B;
(3) by the medicinal liquid A that step (1) obtains, be concentrated into relative density d=1.10-1.20, filter, medicinal liquid, by nonpolar macroporous adsorption resin, first washes with water, and water elution liquid is directly by polar macroporous resin; Use the alcoholic solution eluting nonpolar macroporous adsorption resin of concentration 30%-70% again, collect different concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract C; Use the alcoholic solution eluting polar macroporous adsorption resin of concentration 50%-95% again, collect different concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract D;
(4) by above-mentioned Chrysosplenium extract A, Chrysosplenium extract B, Chrysosplenium extract C, Chrysosplenium extract D mixing, Chrysosplenium extract of the present invention is obtained.
Preferred a kind of Chrysosplenium extract preparation method is:
(1) Chrysosplenium nudicaule Bunge, soaks 6 hours, and adopt extraction by steam distillation volatile oil, 2 hours extraction times, extraction time 2 times, amount of water is 12 times of Chrysosplenium nudicaule Bunge weight, collects volatile oil, obtains Chrysosplenium extract A; Chrysosplenium nudicaule Bunge aqueous extract is filtered, obtains medicinal liquid A and medicinal residues A respectively;
(2) step (1) being obtained medicinal residues A concentration 60% ethanol is solvent, heating and refluxing extraction, and extraction time is 2 times, and each extraction time is 2 hours, each solvent load is 12 times of Chrysosplenium nudicaule Bunge weight, filters, and extracting solution reclaims ethanol, concentrated, dry, obtain Chrysosplenium extract B;
(3) by the medicinal liquid A that step (1) obtains, be concentrated into relative density d=1.12, filter, medicinal liquid, by D101 nonpolar macroporous adsorption resin, first washes with water, the polar macroporous resin of the DM130 that water elution liquid directly passes through; Use the alcoholic solution eluting nonpolar macroporous adsorption resin of concentration 60% again, collect 60% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract C; Use the alcoholic solution eluting DM130 polar macroporous adsorption resin of concentration 75% again, collect 75% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract D;
(4) by above-mentioned Chrysosplenium extract A, Chrysosplenium extract B, Chrysosplenium extract C, Chrysosplenium extract D mixing, Chrysosplenium extract of the present invention is obtained.
The preparation method of a kind of Chrysosplenium extract of the present invention, is characterized in that: the nonpolar macroporous adsorption resin adopted is D101 macroporous adsorbent resin, AB-8; The polar macroporous adsorption resin adopted is DM130 macroporous adsorbent resin, ADS-17 macroporous adsorbent resin.
The preparation method of a kind of Chrysosplenium extract of the present invention and application, the described application be applied as in preparation treatment acute cholecystitis medicine.
The treatment acute cholecystitis medicine that Chrysosplenium extract of the present invention and chemical drugs or Chinese medicine or natural drug form.
Chrysosplenium extract A of the present invention, Chrysosplenium extract B, Chrysosplenium extract C, Chrysosplenium extract D, the application in preparation treatment acute cholecystitis medicine.
The treatment acute cholecystitis medicine that Chrysosplenium extract A of the present invention, Chrysosplenium extract B, Chrysosplenium extract C, Chrysosplenium extract D and chemical drugs or Chinese medicine or natural drug form.
Chrysosplenium extract of the present invention, by adding the various adjuvants that pharmaceutics allows, makes the peroral dosage forms such as the tablet on pharmaceutics, granule, capsule.
Detailed description of the invention
Below by specific experiment example and embodiment, the preparation method of a kind of Chrysosplenium extract of the present invention and the application in preparation treatment acute cholecystitis medicine thereof are described further, but are not limited to the present invention.
Be described in further detail below by specific embodiment.
Embodiment 1: the preparation of Chrysosplenium extract
(1) Chrysosplenium nudicaule Bunge 18kg, soak 6 hours, adopt extraction by steam distillation volatile oil, 2 hours extraction times, extraction time 2 times, amount of water is 12 times of Chrysosplenium nudicaule Bunge weight, collect volatile oil, obtain Chrysosplenium extract A, and Chrysosplenium nudicaule Bunge aqueous extract is filtered, obtain medicinal liquid A and medicinal residues A respectively;
(3) step (1) being obtained medicinal residues A concentration 60% ethanol is solvent, heating and refluxing extraction, and extraction time is 2 times, and each extraction time is 2 hours, each solvent load is 12 times of Chrysosplenium nudicaule Bunge weight, filters, and extracting solution reclaims ethanol, concentrated, dry, obtain Chrysosplenium extract B;
(2) by the medicinal liquid A that step (1) obtains, be concentrated into relative density d=1.12, filter, medicinal liquid, by D101 nonpolar macroporous adsorption resin, first washes with water, the polar macroporous resin of the DM130 that water elution liquid directly passes through; Use the alcoholic solution eluting nonpolar macroporous adsorption resin of concentration 60% again, collect 60% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract C; Use the alcoholic solution eluting DM130 polar macroporous adsorption resin of concentration 75% again, collect 75% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract D;
(4) by above-mentioned Chrysosplenium extract A, Chrysosplenium extract B, Chrysosplenium extract C, Chrysosplenium extract D mixing, Chrysosplenium extract of the present invention is obtained.
Embodiment 2: the preparation of Chrysosplenium extract
(1) Chrysosplenium nudicaule Bunge 22kg, soak 4 hours, adopt extraction by steam distillation volatile oil, 1 hour extraction time, extraction time 3 times, amount of water is 8 times of Chrysosplenium nudicaule Bunge weight, collect volatile oil, obtain Chrysosplenium extract A, and Chrysosplenium nudicaule Bunge aqueous extract is filtered, obtain medicinal liquid A and medicinal residues A respectively;
(3) step (1) being obtained medicinal residues A concentration 50% ethanol is solvent, heating and refluxing extraction, and extraction time is 1 time, and each extraction time is 3 hours, each solvent load is 8 times of Chrysosplenium nudicaule Bunge weight, filters, and extracting solution reclaims ethanol, concentrated, dry, obtain Chrysosplenium extract B;
(2) by the medicinal liquid A that step (1) obtains, be concentrated into relative density d=1.20, filter, medicinal liquid, by AB-8 nonpolar macroporous adsorption resin, first washes with water, and water elution liquid is directly by the polar macroporous resin of ADS-17; Use the alcoholic solution eluting AB-8 nonpolar macroporous adsorption resin of concentration 30% again, collect 30% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract C; Use the alcoholic solution eluting ADS-17 polar macroporous adsorption resin of concentration 50% again, collect 50% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract D;
(4) by above-mentioned Chrysosplenium extract A, Chrysosplenium extract B, Chrysosplenium extract C, Chrysosplenium extract D mixing, Chrysosplenium extract of the present invention is obtained.
Embodiment 3: the preparation of Chrysosplenium extract
(1) Chrysosplenium nudicaule Bunge 21kg, soak 12 hours, adopt extraction by steam distillation volatile oil, 4 hours extraction times, extraction time 1 time, amount of water is 15 times of Chrysosplenium nudicaule Bunge weight, collect volatile oil, obtain Chrysosplenium extract A, and Chrysosplenium nudicaule Bunge aqueous extract is filtered, obtain medicinal liquid A and medicinal residues A respectively;
(3) step (1) being obtained medicinal residues A concentration 95% ethanol is solvent, heating and refluxing extraction, and extraction time is 3 times, and each extraction time is 1 hour, each solvent load is 15 times of Chrysosplenium nudicaule Bunge weight, filters, and extracting solution reclaims ethanol, concentrated, dry, obtain Chrysosplenium extract B;
(2) by the medicinal liquid A that step (1) obtains, be concentrated into relative density d=1.10, filter, medicinal liquid, by D101 nonpolar macroporous adsorption resin, first washes with water, and water elution liquid is directly by the polar macroporous resin of DM130; Use the alcoholic solution eluting D101 nonpolar macroporous adsorption resin of concentration 70% again, collect 70% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract C; Use the alcoholic solution eluting DM130 polar macroporous adsorption resin of concentration 95% again, collect 95% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract D;
(4) by above-mentioned Chrysosplenium extract A, Chrysosplenium extract B, Chrysosplenium extract C, Chrysosplenium extract D mixing, Chrysosplenium extract of the present invention is obtained.
Embodiment 4: the preparation of Chrysosplenium extract tablet
Example 1 Chrysosplenium extract 265g, adds starch 60g, mixing, granulates, dry, sieves, adds microcrystalline Cellulose 15g, magnesium stearate 0.5g, and mixing, is pressed into 1000, obtains Chrysosplenium extract tablet.
Embodiment 5: the preparation of Chrysosplenium extract granule
Example 2 Chrysosplenium extract 265g, adds dextrin 100g, mixing, granulates, and dry, granulate, obtains Chrysosplenium extract granule.
Embodiment 6: the preparation of Chrysosplenium extract capsule
Example 3 Chrysosplenium extract 245g, adds starch 85g, mixing, granulates, and dry, granulate, obtains Chrysosplenium extract capsule by encapsulated 1000.
Experimental example 1: treatment acute cholecystitis
Case enters group standard
Though traditional medicine is without the name of disease of cholecystitis, but the disease of its disease is early recognized with diagnosis and is recorded, the clinical characters of primary disease is upper right abdomen and side of body costalgia or epigastrium pit of the stomach place pain, heating or alternate attack of chill and fever or often have epigastric distension and distress with jaundice, feel sick, the symptom such as heating installation, distention and fullness in the abdomen.Acute and chronic cholecystitis, cholangitis is contained in the disease such as hypochondriac pain, gastropathy, irritability pain, incoordination between the liver and stomach, jaundice, blocked-up chest Shaoyang disease, gallbladder-distention, distension related to the liver of therefore traditional medicine.
Diagnostic criteria: upper right abdomen break-through pain, and take on back radiation to the right, with heating, Nausea and vomiting, health check-up upper right abdominal pressure pain and flesh are defended, and murphy sign is positive, and numeration of leukocyte increases, and B ultrasonic shows gallbladder wall edema, can be diagnosed as acute cholecystitis.
Selector close standard of stating case 40 example, wherein male 20 example, women 20 example, 36 years old mean age.
therapeutic scheme:treatment group gives embodiment 4 Chrysosplenium extract tablet, and it is a course for the treatment of that mild is taken medicine 5-7 days, 2 courses for the treatment of of patient with severe symptoms.
the standard of curative effect evaluation
recovery from illness:the symptoms such as right Upper abdominal pain, nausea and vomiting disappear completely; Upper right of having a medical check-up abdomen, without tenderness, does not touch gallbladder-murphy sign negative; Ultrasound diagnosis gallbladder is normal, shrinks good.
take a turn for the better:right Upper abdominal pain obviously alleviates, there occasionally have to be nauseating, but without vomiting, bitter taste, the light tenderness of upper right of having a medical check-up abdomen, can touch great gallbladder sometimes, and Boas' sign is negative; Numeration of leukocyte and neutrophilic granulocyte normal; Ultrasound diagnosis gallbladder is bigger.
invalid:general Symptoms is without improvement.
therapeutic outcome:transference cure in mild 7 days, transference cure in general 14 days of patient with severe symptoms, blood routine examination is normal.B ultrasonic shows that gallbladder wall edema disappears.Through statistics effective percentage 100%, cure rate 87.5%.
Model case:
1, king's ××, female, 35 years old, autumn in 2011 was ill, time medical, upper right abdomen break-through pain, and take on back radiation to the right, sharp ache, defecates rare.Once quiet metronidazole, oral indometacin 3 days, within 1 day, through taking medicine of the present invention 7, pain relief also progressively disappears, and does not recur so far again repeatedly in drug withdrawal.
2, ×× is opened, man, 45 years old, main suit time medical: recurrent exerbation upper right abdomen break-through pain, companion's Nausea and vomiting.Have a medical check-up: upper right abdominal pressure pain and flesh are defended, and murphy sign is positive, ultrasound diagnosis gallbladder wall edema, through taking medicine of the present invention 10, pain disappears, ultrasound diagnosis: gallbladder wall edema disappears, and does not recur so far.
Claims (2)
1. a preparation method for Chrysosplenium extract, is characterized in that preparing as follows:
(1) Chrysosplenium nudicaule Bunge, soaks 6 hours, and adopt extraction by steam distillation volatile oil, 2 hours extraction times, extraction time 2 times, amount of water is 12 times of Chrysosplenium nudicaule Bunge weight, collects volatile oil, obtains Chrysosplenium extract A; Chrysosplenium nudicaule Bunge aqueous extract is filtered, obtains medicinal liquid A and medicinal residues A respectively;
(2) step (1) being obtained medicinal residues A concentration 60% ethanol is solvent, heating and refluxing extraction, and extraction time is 2 times, and each extraction time is 2 hours, each solvent load is 12 times of Chrysosplenium nudicaule Bunge weight, filters, and extracting solution reclaims ethanol, concentrated, dry, obtain Chrysosplenium extract B;
(3) by the medicinal liquid A that step (1) obtains, be concentrated into relative density 1.12, filter, medicinal liquid, by D101 nonpolar macroporous adsorption resin, first washes with water, and water elution liquid is directly by the polar macroporous resin of DM130; Use the alcoholic solution eluting nonpolar macroporous adsorption resin of concentration 60% again, collect 60% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract C; Use the alcoholic solution eluting DM130 polar macroporous adsorption resin of concentration 75% again, collect 75% concentration ethanol eluent, concentrate drying, obtains Chrysosplenium extract D;
(4) by above-mentioned Chrysosplenium extract A, Chrysosplenium extract B, Chrysosplenium extract C, Chrysosplenium extract D mixing, Chrysosplenium extract is obtained.
2. preparation method according to claim 1, is characterized in that described Chrysosplenium extract, by adding the various adjuvants that pharmaceutics allows, makes tablet oral on pharmaceutics, granule, capsule.
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