CN104587115A - Drug for treating bacillary dysentery and preparation method of oral liquid containing drug for treating bacillary dysentery - Google Patents
Drug for treating bacillary dysentery and preparation method of oral liquid containing drug for treating bacillary dysentery Download PDFInfo
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- CN104587115A CN104587115A CN201310526196.3A CN201310526196A CN104587115A CN 104587115 A CN104587115 A CN 104587115A CN 201310526196 A CN201310526196 A CN 201310526196A CN 104587115 A CN104587115 A CN 104587115A
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Abstract
The invention discloses a drug for treating bacillary dysentery. The drug as a traditional Chinese medicine composition comprises, by weight, 10-60 parts of Chinese angelica, 10-100 parts of white peony root, 10-60 parts of betel nut, 2-20 parts of bitter orange, 5-50 parts of talc, 1-60 parts of costus root, 1-20 parts of radish seed and 1-20 parts of licorice root. The drug can treat bacillary dysentery by treating intestines and stomach epidemic toxin, invigorating spleen and nourishing stomach, and rectifying qi and coursing liver and can improve effects by improving human immunity. The preparation method of an oral liquid containing the drug for treating bacillary dysentery has simple processes. The leached oral liquid can be fast absorbed by the human body and produce effects fast. Through a condensation technology, an oral liquid dosage is reduced and the oral liquid is convenient for carrying, preservation and taking.
Description
Technical field
The invention belongs to a kind of Chinese medicine composition, be specifically related to medicine and the oral liquor thereof for the treatment of bacillary dysentery
.
Background technology
Bacillary dysentery is the common acute infectious intestinal disease caused by dysentery bacterium, with colon suppurative inflammation for major lesions, has systemic toxicity profiles symptom, stomachache, diarrhoea, tenesmus, the clinical manifestations such as evacuation of pus hemafecia.The main cause of bacillary dysentery: epidemic disease caused by damp-heat pathogen poison is invaded and intestinal forms primary disease.Summer and autumn, heat-damp in summer crosses Sheng, weakness of the spleen and stomach, as eating and drinking without temperance or eat unclean product by mistake, or eating cold and uncooked food excessively, or surfeit delicious food savoury equivalent damage taste, resistance of human body reduces, and epidemic disease caused by damp-heat pathogen poison seizes the opportunity to worm one's way into gastrointestinal, retention of damp-heat in the interior or cold-damp is detained, and causes primary disease.
At present, western medical treatment method adopts Western medicine, the chemical drugs that western medicine composition is single, purification product or antibiotic, and therapeutical effect is obvious, but toxic and side effects is comparatively large, and antibiotic life-time service antibiotic can produce drug resistance, endangers larger.Chinese and Western therapeutic alliance is also the method that patient often adopts, but the reaction that Chinese medicine and western medicine coupling occurs comprises pH value change, acid-base neutralization, generation precipitation, complex reaction etc. occurs, generally can produce the impact of the following aspects: affect drug absorption, as containing the more Chinese medicine of calcium, magnesium, aluminum, ferrum, as Gypsum Fibrosum, Mirabilitum crystallina, Os Draconis, Concha Ostreae, Magnetitum, Concha Arcae etc. should not be applied with Cyclomycin family antibiotic compatibility, with with easily forming the metal complex being difficult to absorb later, reduce curative effect of medication; Change the effect of medicine; Or generation noxious substance.So when patient's improper use, can lead to grave consequences, treatment by Chinese herbs aspect is not comprehensive due to medication, causes therapeutic effect not good.
Summary of the invention
Large for prior art western medicines in treatment toxic and side effects, the problems such as Chinese medicine and western medicine therapeutic alliance hidden danger is large, the invention provides a kind of evident in efficacy, medicine for the treatment of bacillary dysentery of having no side effect and oral liquor thereof.
To achieve these goals, the technical solution used in the present invention is: the medicine for the treatment of bacillary dysentery, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 10-60 part, Radix Paeoniae Alba 10-100 part, Semen Arecae 10-60 part, Fructus Aurantii 2-20 part, Talcum 5-50 part, Radix Aucklandiae 1-60 part, Radish seed 1-20 part, Radix Glycyrrhizae 1-20 part.
The weight portion of each crude drug of described Chinese medicine composition is: Radix Angelicae Sinensis 30 parts, the Radix Paeoniae Alba 30 parts, Semen Arecae 15 parts, Fructus Aurantii 10 parts, 10 parts, Talcum, the Radix Aucklandiae 10 parts, Radish seed 3 parts, 3 parts, Radix Glycyrrhizae.
The oral liquor of the medicine for the treatment of bacillary dysentery, concrete steps are as follows:
A, crude drug process, by Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Arecae, Fructus Aurantii, the Radix Aucklandiae, Radix Glycyrrhizae is cleaned, oven dry, reprocesses in flakes or section, Radish seed is milled into coarse powder;
B, lixiviate, add decoction pot by the crude drug of step a process and Talcum and carry out lixiviate, obtain medicine stock solution;
C, purification, carry out purified treatment by step b medicine stock solution through microfilter;
D, concentrated, the medicinal liquid after being purified by step c is condensed into concentrated medicament through backflow, and concentrating degree is to daily measuring 30-60ml;
E, subpackage sterilizing, by loading in sterile chamber after sealing after the concentrated medicament of steps d heating antiseptic, adopt flowing steam method to carry out sterilization treatment.
The lixiviate of described step b, extraction time crude drug and Talcum being added decoction pot is 1-2 hour, decocts the medicine stock solution of filtering after 2-3 time and merging.
In the present invention, the pharmacological property of each raw material is as follows:
Radix Angelicae Sinensis: warm in nature, sweet in the mouth is pungent.GUIXIN, liver, spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation.Control menoxenia, amenorrhea is suffered from abdominal pain, and lump in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer steal, injury from falling down, strengthen immunity, antiinflammatory, protect the liver, radioprotective, antioxidation and scavenging free radicals etc.
The Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.Effect: control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Suitable: people's breast abdomen pain over the hypochondriac region of the blood deficiency deficiency of YIN, pain in the hepatic region, cholecystitis gallstones pain person should eat; Dysentery is suffered from abdominal pain, and women's menalgia person should eat; Spontaneous perspiration easy antiperspirant night sweat person should eat; Sural spasm, spasm of the limbs pain, uneasy lower limb syndrome patients should eat; Coordinate with alleviating various breast abdomen and limbs pain with Radix Glycyrrhizae.
Semen Arecae: bitter in the mouth, pungent, warm in nature.Return stomach, large intestine channel.Effect: parasite killing, removing food stagnancy, the therapeutic method to keep the adverse QI flowing downwards, row water.Cure mainly malnutrition due to parasitic infestation, as ascarid, cestode, pinworm, fasciloopsis etc., stagnation of QI due to dyspepsia, abdominal distention, edema, beriberi, the diseases such as malaria.
Fructus Aurantii: bitter in the mouth is pungent, cool in nature.Enter lung, spleen, stomach, large intestine four warp.Effect: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Fructus Aurantii profit the intestines and stomach, controls the inferior internal hemorrhoid with bleeding dysentery, the secret plug of large intestine.
Talcum: sweet light, cold.Return stomach, urinary bladder channel.Effect: summer-heat excessive thirst, dysuria, watery diarrhea, hematodiarrhoea, gonorrhea, jaundice, edema, epistaxis, beriberi, Skin wet and rotten.
The Radix Aucklandiae: acrid in the mouth is bitter, warm in nature.Return spleen, stomach, liver, lung meridian.Promoting the circulation of QI to relieve pain, for the abdominal distention caused by stagnation of QI in spleen and stomach, lack of appetite vomiting; Regulate the flow of vital energy soothing the liver, for the hypochondriac pain that QI stagnation of the liver and galibladder causes; Spleen invigorating disappears stagnant, the stagnant gas of adjustable gastrointestinal.Treatment stomachache, diarrhoea, tenesmus.
Radish seed: sweet in the mouth, pungent, property is put down.Return lung, spleen, stomach warp.Tool helps digestion effect of de-swelling, lowering the adverse-rising QI to resolve phlegm.
Radix Glycyrrhizae: property is put down, and sweet in the mouth, returns 12 warps.There is removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, grows and coughs lung moistening, and emergency is detoxified, and is in harmonious proportion hundred medicines.Cure mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and large loose stool is thin.
In the present invention, each medicine supplements and complements each other, and the mutual cooperation of various crude drug reaches medicine optimum curative effect.Invade and intestinal for epidemic disease caused by damp-heat pathogen poison, the present invention carrys out sharp the intestines and stomach primarily of this few taste medicine of Semen Arecae, Fructus Aurantii and Radix Glycyrrhizae, and control the inferior hemorrhoid dysentery, large loose stool is thin; Radix Angelicae Sinensis, the Radix Paeoniae Alba, Talcum, Fructus Aurantii, the Radix Aucklandiae, Radish seed and Radix Glycyrrhizae, this few taste medicine is by the stagnant gas of adjustable gastrointestinal, and invigorating the spleen and replenishing QI, emergency is detoxified, and Radix Angelicae Sinensis improves the curative effect of immunity with having, so also improve body immunity while all kinds of medicine plays treatment dysentery.The present invention by treatment the intestines and stomach epidemic disease poison, spleen reinforcing nourishing the stomach and regulate the flow of vital energy and soothing the liverly reach treatment bacillary dysentery, and also heightening the effect of a treatment by improving human immunity.
Oral liquor technique of the present invention is simple, and fast in absorption of human body through the oral liquid leached, dose-effect is rapid; By concentration technology, oral liquid dose reduces, and is easy to carry, preserves and takes; Oral liquid finished product, through sterilization treatment, packs, steady quality, not perishable; Oral liquid can be produced in enormous quantities, removes the trouble that consumer does it yourself to make from, taking convenience.
The present invention in clinical case 100 example, total effective rate 98%, cure rate 96%.
The present invention treats the routine clinical observation result of morbid leukorrhea 100:
1. clinical data: age 10-70 year.
2. administrated method: oral liquid, the morning, noon and afternoon service once, each one bottle, within 15 days, are a course for the treatment of.
3. therapeutic effect
(1) criterion of therapeutical effect
A. fully recover: symptom and sign disappears, do not recur after stopping using;
B. effective: symptom and sign disappears substantially.Comparatively the lighter is recurred after drug withdrawal.
C. invalid: to treat three months with clinical symptoms without improver.
(2) result: 94 examples of fully recovering (accounting for 94%), effective 4 examples (accounting for 4%), invalid 2 examples (accounting for 2%) total effective rate 98%.
Detailed description of the invention
embodiment 1:
The medicine for the treatment of bacillary dysentery, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 10-60 part, Radix Paeoniae Alba 10-100 part, Semen Arecae 10-60 part, Fructus Aurantii 2-20 part, Talcum 5-50 part, Radix Aucklandiae 1-60 part, Radish seed 1-20 part, Radix Glycyrrhizae 1-20 part.
The weight portion of each crude drug of Chinese medicine composition is: Radix Angelicae Sinensis 30 parts, the Radix Paeoniae Alba 30 parts, Semen Arecae 15 parts, Fructus Aurantii 10 parts, 10 parts, Talcum, the Radix Aucklandiae 10 parts, Radish seed 3 parts, 3 parts, Radix Glycyrrhizae.
The oral liquor of the medicine for the treatment of bacillary dysentery, concrete steps are as follows:
A, crude drug process, by Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Arecae, Fructus Aurantii, the Radix Aucklandiae, Radix Glycyrrhizae is cleaned, oven dry, reprocesses in flakes or section, Radish seed is milled into coarse powder;
B, lixiviate, add decoction pot by the crude drug of step a process and Talcum and carry out lixiviate, obtain medicine stock solution;
C, purification, carry out purified treatment by step b medicine stock solution through microfilter;
D, concentrated, the medicinal liquid after being purified by step c is condensed into concentrated medicament through backflow, and concentrating degree is to daily measuring 30-60ml;
E, subpackage sterilizing, by loading in sterile chamber after sealing after the concentrated medicament of steps d heating antiseptic, adopt flowing steam method to carry out sterilization treatment.
The lixiviate of step b, extraction time raw material and Talcum being added decoction pot is 1-2 hour, decocts the medicine stock solution of filtering after 2-3 time and merging.
embodiment 2:
The medicine for the treatment of bacillary dysentery, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 10 parts, the Radix Paeoniae Alba 10 parts, Semen Arecae 10 parts, Fructus Aurantii 2 parts, 5 parts, Talcum, the Radix Aucklandiae 1 part, Radish seed 1 part, 1 part, Radix Glycyrrhizae.
The oral liquor of the medicine for the treatment of bacillary dysentery, concrete steps are as follows:
A, crude drug process, by Radix Angelicae Sinensis 10 parts, the Radix Paeoniae Alba 10 parts, Semen Arecae 10 parts, Fructus Aurantii 2 parts, the Radix Aucklandiae 1 part, Radish seed 1 part, 1 part, Radix Glycyrrhizae is cleaned, oven dry, reprocesses in flakes or section, Radish seed is milled into coarse powder;
B, lixiviate, the crude drug of step a process and 5 parts, Talcum are added decoction pot and carries out lixiviate, extraction time is 1 hour, decocts the medicine stock solution of filtering merging for 2 times afterwards;
C, purification, carry out purified treatment by step b medicine stock solution through microfilter;
D, concentrated, the medicinal liquid after being purified by step c is condensed into concentrated medicament through backflow, and concentrating degree is to daily measuring 60ml;
E, subpackage sterilizing, by loading in sterile chamber after sealing after the concentrated medicament of steps d heating antiseptic, adopt flowing steam method to carry out sterilization treatment.
Case 1: military certain, man, 13 years old, Yuan Kang town, Linzhou City of Henan Province Xihua people from village, stomachache, diarrhoea, the symptoms such as evacuation of pus hemafecia.Take 2 courses for the treatment of of this oral liquid, recovery from illness.
embodiment 3:
The medicine for the treatment of bacillary dysentery, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 60 parts, the Radix Paeoniae Alba 100 parts, Semen Arecae 60 parts, Fructus Aurantii 20 parts, 50 parts, Talcum, the Radix Aucklandiae 60 parts, Radish seed 20 parts, 20 parts, Radix Glycyrrhizae.
The oral liquor of the medicine for the treatment of bacillary dysentery, concrete steps are as follows:
A, crude drug process, by Radix Angelicae Sinensis 60 parts, the Radix Paeoniae Alba 100 parts, Semen Arecae 60 parts, Fructus Aurantii 20 parts, the Radix Aucklandiae 60 parts, Radish seed 20 parts, 20 parts, Radix Glycyrrhizae is cleaned, oven dry, reprocesses in flakes or section, Radish seed is milled into coarse powder;
B, lixiviate, the crude drug of step a process and 50 parts, Talcum are added decoction pot and carries out lixiviate, extraction time is 2 hours, decocts the medicine stock solution of filtering merging for 3 times afterwards;
C, purification, carry out purified treatment by step b medicine stock solution through microfilter;
D, concentrated, the medicinal liquid after being purified by step c is condensed into concentrated medicament through backflow, and concentrating degree is to daily measuring 30ml;
E, subpackage sterilizing, by loading in sterile chamber after sealing after the concentrated medicament of steps d heating antiseptic, adopt flowing steam method to carry out sterilization treatment.
Case 2: Zhang, man, 21 years old, Yuan Kang town, Linzhou City of Henan Province Xihua people from village, suffocating pain over the chest, chest pain radiating to the back, losed heart, pants.Take 3 courses for the treatment of of this oral liquid, recovery from illness.
embodiment 4:
The medicine for the treatment of bacillary dysentery, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 40 parts, the Radix Paeoniae Alba 50 parts, Semen Arecae 30 parts, Fructus Aurantii 15 parts, 20 parts, Talcum, the Radix Aucklandiae 40 parts, Radish seed 10 parts, 10 parts, Radix Glycyrrhizae.
The oral liquor of the medicine for the treatment of bacillary dysentery, concrete steps are as follows:
A, crude drug process, by Radix Angelicae Sinensis 40 parts, the Radix Paeoniae Alba 50 parts, Semen Arecae 30 parts, Fructus Aurantii 15 parts, the Radix Aucklandiae 40 parts, Radish seed 10 parts, 10 parts, Radix Glycyrrhizae is cleaned, oven dry, reprocesses in flakes or section, Radish seed is milled into coarse powder;
B, lixiviate, the crude drug of step a process and 20 parts, Talcum are added decoction pot and carries out lixiviate, extraction time is 2 hours, decocts the medicine stock solution of filtering merging for 3 times afterwards;
C, purification, carry out purified treatment by step b medicine stock solution through microfilter;
D, concentrated, the medicinal liquid after being purified by step c is condensed into concentrated medicament through backflow, and concentrating degree is to daily measuring 45ml;
E, subpackage sterilizing, by loading in sterile chamber after sealing after the concentrated medicament of steps d heating antiseptic, adopt flowing steam method to carry out sterilization treatment.
Case 3: Liu, female, 40 years old, Yuan Kang town, Linzhou City of Henan Province Xihua people from village, diarrhoea was more than, tenesmus, the symptoms such as hemafecia.Take 3 courses for the treatment of of this oral liquid, recovery from illness.
embodiment 5:
The medicine for the treatment of bacillary dysentery, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 60 parts, Semen Arecae 50 parts, Fructus Aurantii 8 parts, 25 parts, Talcum, the Radix Aucklandiae 30 parts, Radish seed 15 parts, 15 parts, Radix Glycyrrhizae.
The oral liquor of the medicine for the treatment of bacillary dysentery, concrete steps are as follows:
A, crude drug process, by Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 60 parts, Semen Arecae 50 parts, Fructus Aurantii 8 parts, the Radix Aucklandiae 30 parts, Radish seed 15 parts, 15 parts, Radix Glycyrrhizae is cleaned, oven dry, reprocesses in flakes or section, Radish seed is milled into coarse powder;
B, lixiviate, the crude drug of step a process and 25 parts, Talcum are added decoction pot and carries out lixiviate, extraction time is 1 hour, decocts the medicine stock solution of filtering merging for 3 times afterwards;
C, purification, carry out purified treatment by step b medicine stock solution through microfilter;
D, concentrated, the medicinal liquid after being purified by step c is condensed into concentrated medicament through backflow, and concentrating degree is to daily measuring 30ml;
E, subpackage sterilizing, by loading in sterile chamber after sealing after the concentrated medicament of steps d heating antiseptic, adopt flowing steam method to carry out sterilization treatment.
Case 4: Wang, man, 70 years old, Yuan Kang town, Linzhou City of Henan Province Xihua people from village, diarrhoea, stomachache, diarrhoea, felt sick, vomiting, the symptoms such as headache.Take 4 courses for the treatment of of this oral liquid, recovery from illness.
embodiment 6:
The medicine for the treatment of bacillary dysentery, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 30 parts, the Radix Paeoniae Alba 80 parts, Semen Arecae 40 parts, Fructus Aurantii 15 parts, 30 parts, Talcum, the Radix Aucklandiae 45 parts, Radish seed 12 parts, 5 parts, Radix Glycyrrhizae.
The oral liquor of the medicine for the treatment of bacillary dysentery, concrete steps are as follows:
A, crude drug process, by Radix Angelicae Sinensis 30 parts, the Radix Paeoniae Alba 80 parts, Semen Arecae 40 parts, Fructus Aurantii 15 parts, the Radix Aucklandiae 45 parts, Radish seed 12 parts, 5 parts, Radix Glycyrrhizae is cleaned, oven dry, reprocesses in flakes or section, Radish seed is milled into coarse powder;
B, lixiviate, the crude drug of step a process and 30 parts, Talcum are added decoction pot and carries out lixiviate, extraction time is 2 hours, decocts the medicine stock solution of filtering merging for 3 times afterwards;
C, purification, carry out purified treatment by step b medicine stock solution through microfilter;
D, concentrated, the medicinal liquid after being purified by step c is condensed into concentrated medicament through backflow, and concentrating degree is to daily measuring 40ml;
E, subpackage sterilizing, by loading in sterile chamber after sealing after the concentrated medicament of steps d heating antiseptic, adopt flowing steam method to carry out sterilization treatment.
Case 5: go into business certain, man, 9 years old, Yuan Kang town, Linzhou City of Henan Province Xihua people from village, fever, Recurrent Vomiting, pale complexion, coolness of extremities, stomachache, diarrhoea.Take 3 courses for the treatment of of this oral liquid, recovery from illness.
Claims (4)
1. treat the medicine of bacillary dysentery, it is characterized in that: this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 10-60 part, Radix Paeoniae Alba 10-100 part, Semen Arecae 10-60 part, Fructus Aurantii 2-20 part, Talcum 5-50 part, Radix Aucklandiae 1-60 part, Radish seed 1-20 part, Radix Glycyrrhizae 1-20 part.
2. the medicine for the treatment of bacillary dysentery according to claim 1, is characterized in that: the weight portion of each crude drug of described Chinese medicine composition is: Radix Angelicae Sinensis 30 parts, the Radix Paeoniae Alba 30 parts, Semen Arecae 15 parts, Fructus Aurantii 10 parts, 10 parts, Talcum, the Radix Aucklandiae 10 parts, Radish seed 3 parts, 3 parts, Radix Glycyrrhizae.
3. the oral liquor of the medicine for the treatment of bacillary dysentery according to claim 1 and 2, is characterized in that: concrete steps are as follows:
A, crude drug process, by Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Arecae, Fructus Aurantii, the Radix Aucklandiae, Radix Glycyrrhizae is cleaned, oven dry, reprocesses in flakes or section, Radish seed is milled into coarse powder;
B, lixiviate, add decoction pot by the crude drug of step a process and Talcum and carry out lixiviate, obtain medicine stock solution;
C, purification, carry out purified treatment by step b medicine stock solution through microfilter;
D, concentrated, the medicinal liquid after being purified by step c is condensed into concentrated medicament through backflow, and concentrating degree is to daily measuring 30-60ml;
E, subpackage sterilizing, by loading in sterile chamber after sealing after the concentrated medicament of steps d heating antiseptic, adopt flowing steam method to carry out sterilization treatment.
4. the oral liquor of the medicine for the treatment of bacillary dysentery according to claim 3, it is characterized in that: the lixiviate of described step b, extraction time crude drug and Talcum being added decoction pot is 1-2 hour, decocts the medicine stock solution of filtering after 2-3 time and merging.
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Application publication date: 20150506 |