CN102872261B - The application of Physalis pubescens L. in the medicine of preparation treatment acute cholecystitis - Google Patents
The application of Physalis pubescens L. in the medicine of preparation treatment acute cholecystitis Download PDFInfo
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- CN102872261B CN102872261B CN201210360564.7A CN201210360564A CN102872261B CN 102872261 B CN102872261 B CN 102872261B CN 201210360564 A CN201210360564 A CN 201210360564A CN 102872261 B CN102872261 B CN 102872261B
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Abstract
The invention discloses application and products thereof in the medicine of preparation treatment cholecystitis of Physalis pubescens L. and preparation method, medicine of the present invention take Physalis pubescens L. as the preparation of crude drug.Can directly pulverize, pulverize after concocting or obtain extract with water or ethanol extraction, preparation process makes various dosage form routinely, instant invention overcomes the defect of prior art, provide the application of Physalis pubescens L. in the medicine of preparation treatment cholecystitis, process for preparing medicine provided by the present invention is simple, and cost is low, clinical trial confirms that this medicine has significant clinical efficacy to cholecystitis, and not easily recurs after curing.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine pharmacy, particularly relate to the application of Physalis pubescens L. in the medicine of preparation treatment acute cholecystitis.
Background technology
Cholecystitis is the gallbladder inflammatory lesion that bacterial infection or chemical irritation (bile component change) cause, and is the commonly encountered diseases of gallbladder.In abdominal surgery, its sickness rate is only second to appendicitis, and primary disease is more common in the middle age of 35 ~ 55 years old, and the women comparatively male that falls ill for many, is more common in obesity and the women of multiple pregnancies especially.Relax clinical performance according to the urgency of morbidity and can be divided into acute and chronic two classes, all belong to biliary infection category.The symptom of acute cholecystitis, mainly contains upper right abdomen pain, Nausea and vomiting and heating etc.Acute cholecystitis can cause right Upper abdominal pain, at the beginning pain and biliary colic closely similar, but its time continued of the stomachache that causes of acute cholecystitis is often longer, breathes and change position usually to make pain increase the weight of, therefore patient likes reposing to the right more, to alleviate abdomen pain.Some patient has nausea and vomiting, but vomiting is general inviolent.Most patient is also with heating, and body temperature is usually between 38.0 DEG C ~ 38.5 DEG C, and Gao Re is actually rare with shiver with cold.A few patients also has the white of the eye and skin slightly to turn to be yellow.When doctor checks the abdominal part of patient, can find that right upper quadrant of the abdomen has tenderness, and have tension of abdominal muscle, the gallbladder of enlargement can also be touched greatly in the patient of 1/3.The blood of chemical examination patient, can find the numeration of leukocyte in most human blood and neutrophilia.Ultrasound diagnosis can find gollbladder dilation, cyst wall thickens, and visible calculus gets lodged in the cervical region of gallbladder.According to above symptom, physical examination and various auxiliary examination, doctor generally can make the diagnosis of acute cholecystitis in time.
Western medical treatment divides expectant treatment and operative treatment.Expectant treatment is to lie up, and strengthen nutrition, the intravenous drip of medicine many employings antibiotics, indometacin is oral, though achieve the good effect of short-term, easily repeatedly; Operative treatment is excision cholecystitis, but the mortality rate 0.5-3% of operative therapy, jaundice case mortality is 10-15%, and gerontal case mortality rate is up to 13.5-16%, and operation intercurrent disease is about 15%.Therefore operative therapy as treatment cholecystitis basic therapy be unsafty.The Chinese medicine of current treatment cholecystitis mainly contains, Decoction of Gentiana for Purging the Liver-fire, depressed liver-energy dispersing and function of gallbladder promoting soup, soothing liver-QI Stomach-Regulating Decoction, stomach invigorating circulation of qi promoting soup, XIAOYAN LIDAN PIAN, depressed liver-energy dispersing and function of gallbladder promoting cream, clearing gallbladder circulation of qi promoting soup, clearing away heat-damp and promoting diuresis soup, clearing gallbladder pathogenic fire purging soup, bupleurum root decoction, tarragon soup adjust that five a kind of reed mentioned in ancient books are loose, Herba Artemisiae Scopariae and CHENGQI TANG, Daxianxiong Tang etc., although these medicines have certain curative effect, but still can not be satisfactory.
Physalis pubescens L. is plant of Solanaceae Physalis pubescens L. platymiscium Physalis pubescens L. PhysalispubescensL..Physalis pubescens L., nature and flavor bitter cold, return lung meridian, has heat-clearing and toxic substances removing, sore-throat relieving, reduces phlegm, the effect such as diuresis, can be used for pharyngalgia silent, the treatment of the disease such as phlegm-heat cough, dysuria, external treatment pemphigus, eczema.Modern pharmacological research shows, Physalis pubescens L. has antiinflammatory, antibacterial, anticancer isoreactivity, and its Anti-inflammatory Mechanism is the generation of normal human peripheral blood's polymorphonuclear leukocyte (PMN) oxygen-derived free radicals always and release and plays a role.Up to now, very few to the report of the treatment cholecystitis activity of Physalis pubescens L. both at home and abroad.
Document " the bacteriostatic activity research of Physalis pubescens L extract " (Zheng Jingtong, the bacteriostatic activity research of Physalis pubescens L extract, Chinese experimental diagnostics, the 14th volume the 6th phase in 2010) disclose the research of the antibacterial aspect of Physalis pubescens L. chemical composition, comprise ethanol extraction, extract bacteriostatic activity is tested.Document " chemical constitution study of hirsutic acid alkali " (Zhang Hui, the chemical constitution study of hirsutic acid alkali, Chinese herbal medicine, o. 11th in 2010), discloses the chemical constitution study of the dry Constellation calyx of Physalis pubescens L., is separated and obtains 4 phytosterin compounds and 11 flavone compounds.
Number of patent application be CN201110360206.1 patent discloses a kind of compound with anti-tumor activity and its preparation method and application.To sum up, there is not yet the open report of relevant Physalis pubescens L. treatment cholecystitis.
Summary of the invention
Technical problem to be solved by this invention is to provide Physalis pubescens L. application in the medicine of preparation treatment cholecystitis and products thereof and preparation method.Medicine of the present invention is preparation prepared by Physalis pubescens L. or its extract, and preparation method is simple, and cost is low, and preparation effectively can treat cholecystitis.In order to solve the problems of the technologies described above, the present invention adopts following technical scheme:
The application of Physalis pubescens L. in the medicine of preparation treatment acute cholecystitis, wherein said Physalis pubescens L. is with Physalis pubescens L and or Physalis pubescens L. seed and or Physalis pubescens L. stem and or hirsutic acid paddle and or Physalis pubescens L. Constellation calyx and or the medicine that is prepared from for crude drug of Physalis pubescens L. root.
the medicine for the treatment of acute cholecystitis of the present invention is raw material with Physalis pubescens L., and preparation method comprises the steps:
Get Physalis pubescens L., put in hot pot, when frying with high heat to surface coke black, inner coke yellow, spray clear water is a little, extinguishes Mars, takes out, dries; Or put and forge in pot, sealing, be stewingly calcined to, cool, taking-up, be ground into the fine powder of 30-150 micron, technique is prepared into various dosage form routinely.
the medicine for the treatment of acute cholecystitis of the present invention take Physalis pubescens L. as raw material, and preparation method can also comprise the steps:
Get Physalis pubescens L. to add water or ethanol extraction, filter, filtrate is condensed into extractum, and preparation process makes various dosage form routinely.Concrete preparation method is:
Get Physalis pubescens L., add 6-14 times of weight water or ethanol extraction 1-4 time, filter, merging filtrate, it is the extractum of 1.10-1.40 that filtrate is concentrated into 60 DEG C of relative densities, and preparation process makes various dosage form routinely.
Wherein water or alcohol extraction procedure comprise decoction, seepage pressure effects, reflux, extract; The method for concentration of filtrate comprises vacuum-concentrcted and microwave vacuum drying.
Technical scheme of the present invention provides the single preparations of ephedrine with the treatment cholecystitis prepared by Physalis pubescens L., also can carry out compatibility with Physalis pubescens L. and other crude drug and prepare the compound preparation being used for the treatment of cholecystitis comprising Physalis pubescens L..
The pass of weight and volume of the present invention is g/ml or kg/L.
tool of the present invention has the following advantages:
1, the medicine for the treatment of cholecystitis of the present invention, select Physalis pubescens L and or Physalis pubescens L. seed and or Physalis pubescens L. stem and or hirsutic acid paddle and or Physalis pubescens L. Constellation calyx and or Physalis pubescens L. root be that crude drug is prepared from, take full advantage of crude drug, avoid waste, forge after carbon process of preparing Chinese medicine process through sustainability, treatment cholecystitis Be very effective;
2, the invention provides a kind of medicine for the treatment of cholecystitis, proved by clinical trial, this medicine, to the cholecystitis caused by upper many reasons, all has good therapeutical effect, achieves the remarkable result of total effective rate 100%, may be used for the treatment of cholecystitis;
3, the process for preparing medicine for the treatment of cholecystitis of the present invention, adopt the modern process of preparing Chinese medicine or the technology such as preparation, preparation of extracting to realize, both provided the single preparations of ephedrine with the treatment cholecystitis prepared by Physalis pubescens L., and also can carry out compatibility with Physalis pubescens L. and other crude drug and prepare the compound preparation being used for the treatment of cholecystitis comprising Physalis pubescens L..
Essence for a better understanding of the present invention, below by the result of the test of this medicine of clinical observation in treatment " cholecystitis ", illustrates its application at pharmaceutical field.
experimental example 1: treatment acute cholecystitis
case enters group standard
Though traditional medicine is without the name of disease of cholecystitis, but the disease of its disease is early recognized with diagnosis and is recorded, the clinical characters of primary disease is upper right abdomen and side of body costalgia or epigastrium pit of the stomach place pain, heating or alternate attack of chill and fever or often have epigastric distension and distress with jaundice, feel sick, the symptom such as heating installation, distention and fullness in the abdomen.Acute and chronic cholecystitis, cholangitis is contained in the disease such as hypochondriac pain, gastropathy, irritability pain, incoordination between the liver and stomach, jaundice, blocked-up chest Shaoyang disease, gallbladder-distention, distension related to the liver of therefore traditional medicine;
Diagnostic criteria: upper right abdomen break-through pain, and take on back radiation to the right, with heating, Nausea and vomiting, health check-up upper right abdominal pressure pain and flesh are defended, and murphy sign is positive, and numeration of leukocyte increases, and B ultrasonic shows gallbladder wall edema, can be diagnosed as acute cholecystitis;
Selector close standard of stating case 40 example, wherein male 20 example, women 20 example, 36 years old mean age;
therapeutic scheme
Treatment group gives embodiment 1 medicine, and it is a course for the treatment of that mild is taken medicine 5-7 days, 2 courses for the treatment of of patient with severe symptoms;
the standard of curative effect evaluation
recovery from illness:the symptoms such as right Upper abdominal pain, nausea and vomiting disappear completely; Upper right of having a medical check-up abdomen, without tenderness, does not touch gallbladder-murphy sign negative; Ultrasound diagnosis gallbladder is normal, shrinks good;
take a turn for the better:right Upper abdominal pain obviously alleviates, there occasionally have to be nauseating, but without vomiting, bitter taste, the light tenderness of upper right of having a medical check-up abdomen, can touch great gallbladder sometimes, and Boas' sign is negative; Numeration of leukocyte and neutrophilic granulocyte normal; Ultrasound diagnosis gallbladder is bigger;
invalid:general Symptoms is without improvement;
therapeutic outcome:transference cure in mild 7 days, transference cure in general 14 days of patient with severe symptoms, blood routine examination is normal.B ultrasonic shows that gallbladder wall edema disappears.Through statistics effective percentage 100%, cure rate 87.5%.
Model case:
1, Shao's ××, female, 35 years old, autumn in 2010 was ill, time medical, upper right abdomen break-through pain, and take on back radiation to the right, sharp ache, defecates rare.Once quiet metronidazole, oral indometacin 3 days, within 1 day, through taking medicine of the present invention 7 doses, pain relief also progressively disappears, and does not recur so far again repeatedly in drug withdrawal;
2, Lee's ××, man, 45 years old, main suit time medical: recurrent exerbation upper right abdomen break-through pain, companion's Nausea and vomiting.Have a medical check-up: upper right abdominal pressure pain and flesh are defended, and murphy sign is positive, ultrasound diagnosis gallbladder wall edema, through taking medicine of the present invention 10 doses, pain disappears, ultrasound diagnosis: gallbladder wall edema disappears, and does not recur so far.
Detailed description of the invention
Following embodiment is for illustrating that the present invention treats the preparation of cholecystitis medicine, but it can not form any restriction to scope of the present invention.
the preparation of embodiment 1 medicine
Treat a medicine for cholecystitis, crude drug: Physalis pubescens L
Preparation method: get Physalis pubescens L, puts in hot pot, and when frying with high heat to surface coke black, inner coke yellow, spray clear water is a little, extinguishes Mars, takes out, dries, be ground into the fine powder of 50 microns, obtain final product.
the preparation of embodiment 2 pharmaceutical preparation
Treat a medicine for cholecystitis, crude drug: the Physalis pubescens L of band Constellation calyx
Preparation method: get Physalis pubescens L, puts in hot pot, and when frying with high heat to surface coke black, inner coke yellow, spray clear water is a little, extinguishes Mars, and take out, dry, be ground into the fine powder of 30 microns, technique is prepared into tablet, capsule, granule routinely.
the preparation of embodiment 3 pharmaceutical preparation
Treat a medicine for cholecystitis, crude drug: Physalis pubescens L. Constellation calyx
Preparation method: get Physalis pubescens L, puts and forges in pot, sealing, boils in a covered pot over a slow fire and is calcined to, cool, and take out, be ground into the fine powder of 150 microns, technique is prepared into drop pill, micropill, dispersible tablet routinely.
the preparation of embodiment 4 pharmaceutical preparation
Treat a medicine for cholecystitis, crude drug: Physalis pubescens L
Preparation method: get Physalis pubescens L, is ground into the fine powder of 30-150 micron, and technique is prepared into the dosage forms such as tablet, capsule, granule, drop pill, micropill, dispersible tablet routinely.
the preparation of embodiment 5 pharmaceutical preparation
Treat a medicine for cholecystitis, crude drug: Physalis pubescens L. stem and hirsutic acid paddle
Preparation method:
Get Physalis pubescens L. stem and hirsutic acid paddle to add water 6 times of weight soak by water 4 times, each 1h, filter, it is the extractum of 1.15 that filtrate is condensed into 60 DEG C of relative densities, and preparation process makes various dosage form routinely.
the preparation of embodiment 6 pharmaceutical preparation
Treat a medicine for cholecystitis, crude drug: Physalis pubescens L. root, Physalis pubescens L. stem and hirsutic acid paddle
Preparation method:
Physalis pubescens L. root, Physalis pubescens L. stem and hirsutic acid paddle add water 14 times of weight water reflux, extract, 1 time, and extract 2h, filter, it is the extractum of 1.38 that filtrate is condensed into 60 DEG C of relative densities, microwave vacuum drying, preparation process makes various dosage form routinely.
the preparation of embodiment 7 pharmaceutical preparation
Treat a medicine for cholecystitis, crude drug: Physalis pubescens L. root
Preparation method:
Physalis pubescens L. root is pulverized, and adds ethanol 14 times of weight water seepage pressure effects 1 time, extracts 2h, and filter, it is the extractum of 1.20 that filtrate is condensed into 60 DEG C of relative densities, and vacuum decompression is dry, and preparation process makes various dosage form routinely.
the preparation of embodiment 8 pharmaceutical preparation
Treat a medicine for cholecystitis, crude drug: Physalis pubescens L. root, Physalis pubescens L. stem, hirsutic acid paddle, Physalis pubescens L, Physalis pubescens L. Constellation calyx
Preparation method:
Physalis pubescens L. root, Physalis pubescens L. stem, hirsutic acid paddle, Physalis pubescens L, Physalis pubescens L. Constellation calyx, mixing, adds ethanol 8 times of weight water reflux, extract, 2 times, each extraction 2h, filter, it is the extractum of 1.30 that filtrate is condensed into 60 DEG C of relative densities, vacuum decompression is dry, and preparation process makes various dosage form routinely.
embodiment 9 is containing the preparation being used for the treatment of the compound preparation of cholecystitis of Physalis pubescens L.
Treat a medicine for cholecystitis, crude drug: Physalis pubescens L. root, Physalis pubescens L. stem, hirsutic acid paddle, Physalis pubescens L. seed, Physalis pubescens L, Physalis pubescens L. Constellation calyx;
Preparation method:
Physalis pubescens L. root, Physalis pubescens L. stem, hirsutic acid paddle, Physalis pubescens L, Physalis pubescens L. Constellation calyx, mixing, add ethanol 8 times of weight water reflux, extract, 2 times, each extraction 2h, filter, it is the extractum of 1.30 that filtrate is condensed into 60 DEG C of relative densities, vacuum decompression is dry, extract obtained, as crude drug and following single or multi-flavor medical material compatibility, the medicine as treatment cholecystitis:
Radix Bupleuri, Fructus Aurantii Immaturus, Rhizoma Corydalis, Fructus Toosendan, Radix Glycyrrhizae Preparata, Herba Lysimachiae, Spora Lygodii, Radix Curcumae, Endothelium Corneum Gigeriae Galli (parched), Fructus Gardeniae, Cortex Moutan, Radix Scutellariae, Herba Dendrobii, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Fructus Amomi, the Radix Astragali, Rhizoma Cimicifugae, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Radix Scutellariae, Rhizoma Zingiberis, Rhizoma Pinelliae Preparata, Radix Codonopsis, Fructus Jujubae, Radix Gentianae, dandelion, Fructus Evodiae, Rhizoma Alpiniae Officinarum, Fructus Aurantii, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Artemisiae Scopariae, Rhizoma Atractylodis Macrocephalae (parched), Os Sepiae, Concha Arcae, Poria, Caulis Bambusae In Taenia, Fructus Citri Sarcodactylis, Caulis Perillae, Herba Andrographis, Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae, Folium Perillae, Bulbus Lilii, the Radix Linderae, Polyporus, the Radix Aucklandiae, Radix Puerariae, Fructus Mume.
Claims (1)
1. the application of Physalis pubescens L in preparation treatment acute cholecystitis medicine, it is characterized in that the preparation method of described Physalis pubescens L is: get Physalis pubescens L, put in hot pot, when frying with high heat to surface coke black, inner coke yellow, spray clear water is a little, extinguishes Mars, take out, dry, be ground into the fine powder of 30 microns, technique is prepared into tablet, capsule or granule routinely.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103417745B (en) * | 2013-08-05 | 2015-04-22 | 张艳 | Chinese herbal preparation for treating acute cholecystitis and preparation method thereof |
| CN103610029B (en) * | 2013-11-28 | 2015-05-13 | 东北农业大学 | Method for extracting uranidin from physalis pubescens fruit |
| CN104189163A (en) * | 2014-08-21 | 2014-12-10 | 李芝芳 | Traditional Chinese medicine formula for treating cholecystitis |
| CN104524473A (en) * | 2015-01-15 | 2015-04-22 | 王金强 | Bile duct calculus treating drug preparation and preparing method |
| CN104740009A (en) * | 2015-03-16 | 2015-07-01 | 鄢明亮 | Traditional Chinese medicine composition for treating chronic cholecystitis and preparation method thereof |
| CN105106821A (en) * | 2015-09-23 | 2015-12-02 | 董春年 | Traditional Chinese medicine preparation for treating cholecystitis |
| CN112957402A (en) * | 2021-04-22 | 2021-06-15 | 黑龙江中医药大学 | Medicinal preparation for treating damp-heat in liver and gallbladder and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1320399A (en) * | 2001-04-24 | 2001-11-07 | 刘秀才 | Physalis alkekengi juice beverage and preparing process thereof |
| CN101244153A (en) * | 2008-02-01 | 2008-08-20 | 张炯怡 | Application of alkekengi in preparing medicament for treating digestive system disease, product and preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1320399A (en) * | 2001-04-24 | 2001-11-07 | 刘秀才 | Physalis alkekengi juice beverage and preparing process thereof |
| CN101244153A (en) * | 2008-02-01 | 2008-08-20 | 张炯怡 | Application of alkekengi in preparing medicament for treating digestive system disease, product and preparation |
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