CN104740009A - Traditional Chinese medicine composition for treating chronic cholecystitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic cholecystitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating chronic cholecystitis and a preparation method thereof. The medicine is prepared by 150-200 parts of radix bupleuri, 100-200 parts of fructus aurantii, 80-100 parts of radix paeoniae alba, 30-60 parts of liquorice, 200-250 parts of lysimachia christinae Hance, 200-300 parts of oriental wormwood, 800-1000 parts of soybeans, 800-1000 parts of spina date seeds, 80-100 parts of rhizoma corydalis and 80-100 parts of felwort. The medicine mainly aims to chromic, acute or sub-acute repeated attack cholecystitis or gall bladder abnormality caused by long-term existent gallstone; with heat clearing and toxicity removing medicines and pain relieving medicines, the functions of clearing heat and resolving dampness and swelling and pain relieving are achieved; the traditional Chinese medicine composition is good in treating effect, stable in component, convenient to take, free of side or toxic effect and simple in manufacturing process.
Description
Technical field
The present invention relates to medical science cholecystitis field, in order to solve the problem of chronic, the acute or subacute cholecystitis of existing treatment, the invention provides especially a kind of Chinese medicine preparation and preparation method for the treatment of chronic cholecystitis.
Background technology
Cholecystitis is more common disease, and sickness rate is higher.According to its clinical manifestation and clinical process, can be divided into again acute with chronic two types, normal and cholelithiasis merges and exists.Upper right abdomen severe pain or angor, mostly be calculus or parasite incarceration and block acute cholecystitis caused by neck of gallbladder, pain often breaks out, and very acutely, or presents angor sample.During cystic duct non-obstructivity acute cholecystitis, right Upper abdominal pain is general inviolent, and mostly be persistence distending pain, along with the progress of gallbladder inflammation, pain also can increase the weight of, and pain presents radioactivity, and modal radiation position is the place such as right shoulder and right inferior angle of scapula.Chronic cholecystitis is by acute or subacute cholecystitis recurrent exerbation, or gallbladder function caused by long-standing cholelithiasis is abnormal, and the patient of about 25% exists bacteriological infection, and its pathogenesis basis is cystic duct or obstruction of common bile duct.Whether there is calculus according in gallbladder, be divided into calcareous cholecystitis and non-calcareous cholecystitis.Non-calcareous cholecystitis is the chronic cholecystitis caused by antibacterial, viral infection or cholate and pancreatin.Cholecystitis Chinese medicine composition species relevant is at present a lot, but it is not strong to there is specific aim, the problems such as effect is not remarkable.
Summary of the invention
The object of the invention is exactly provide a kind of Chinese medicine preparation and preparation method for the treatment of chronic cholecystitis for above-mentioned deficiency.Patient can be eased by symptom after taking this Chinese medicine composition, the advantage such as simultaneously also have stable dose components, taking convenience, have no side effect.
For achieving the above object, the present invention proposes following technical scheme:
Treat a Chinese medicine preparation for chronic cholecystitis, configured by each raw material of following weight Chinese medicine and form: Radix Bupleuri 150 ~ 200 parts, Fructus Aurantii 100 ~ 200 parts, the Radix Paeoniae Alba 80 ~ 100 parts, 30 ~ 60 parts, Radix Glycyrrhizae, Herba Lysimachiae 200 ~ 250 parts, Herba Artemisiae Scopariae 200 ~ 300 parts, Semen Glycines 800 ~ 1000 parts, Semen Ziziphi Spinosae 800 ~ 1000 parts, Rhizoma Corydalis 80 ~ 100 parts, Radix Gentianae 80 ~ 100 parts.
A kind of Chinese medicine preparation for the treatment of chronic cholecystitis of the present invention, the preferred each parts by weight of raw materials proportioning of Chinese medicine is: Radix Bupleuri 150 parts, Fructus Aurantii 120 parts, the Radix Paeoniae Alba 80 parts, 30 parts, Radix Glycyrrhizae, Herba Lysimachiae 200 parts, Herba Artemisiae Scopariae 300 parts, Semen Glycines 800 parts, Semen Ziziphi Spinosae 800 parts, Rhizoma Corydalis 100 parts, Radix Gentianae 100 parts.
The medical material that the present invention uses has following characteristic:
Radix Bupleuri: Radix Bupleuri, Chinese medicine name.For the medical herbs that " Chinese Pharmacopoeia " includes, medicinal part is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Spring, Qiu Erji excavate, removing stem and leaf and silt, dry.Radix Bupleuri is conventional diaphoretic medicine.Acrid in the mouth, hardship, cold nature.Attending effectiveness: have reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.
Fructus Aurantii: Fructus Aurantii is the medical herbs that " Chinese Pharmacopoeia " includes, medicinal source is the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantiumL. and variety thereof.Fructus Aurantii property is bitter, pungent, sour, warm, has effect of regulating the flow of QI to ease the stomach, the stagnant relieving distension of row, and cure mainly the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, the diseases such as sub-official's prolapsus.
The Radix Paeoniae Alba: (Classification system Paeoniae Radix Alba) source-be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactifloraPall..Leaf alternate, has long handle; The lower portion of the stem leaf is go out winglike compound leaf two times three, and branch end is single leaf; Narrow avette, the lanceolar of lobule or ellipse, the little tooth of leaf margin tool hyaloidin.Cold nature, bitter in the mouth, acid.Return liver, spleen channel.Attending effectiveness: nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
Radix Glycyrrhizae: the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. G.inflata Bat. or Glycyrrhiza glabra L. G.glabra L..Property flat taste sweet flavour enters the spleen, stomach warp, attending effectiveness: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Herba Lysimachiae: original name Herba Dichodrae, another name: Lysimachia christinae Hance, Drymoglossum subcordatum, Cui Pingcao, lotus bud grass, careless, the JINSUOSHI of Boiled small dumplings with pork, Herba Glechomae etc.Latin literary fame is Dichondra repens Forst. tubular flower order, the perennial herbelet of crawling of Convolvulaceae.Kidney-shaped leaves are extremely circular, diameter 4-25 millimeter, and spend single leave axil, anthocaulus is shorter than petiole, thread; Greenery, open yellow little Hua.Nature and flavor-sweet in the mouth, micro-hardship, cool in nature.Attending effectiveness: relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle.
Herba Artemisiae Scopariae: Herba Artemisiae Scopariae, Chinese medicine name.For the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparza Waldst.et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..Bitter in the mouth, pungent, cold nature.Attending effectiveness: have eliminating damp-heat, effect of promoting the function of the gallbladder to alleviate jaundice, for jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
Semen Glycines: Semen Glycines (formal name used at school: Glycine max) is again black soyabean with green kernel, Semen sojae atricolor, mud bean, SEMEN GLYCINE, fodder food bean, and Semen sojae atricolor sweet in the mouth, property are flat, and attending effectiveness: have spleen invigorating alleviating distention in middle-JIAO, moisturizes effect of the water that disappears, heat-clearing and toxic substances removing, QI invigorating.
Semen Ziziphi Spinosae: this product is the dry mature seed " Chinese Pharmacopoeia " of Rhamnaceae plant Ziziphi Spinosae Ziziphus jujuba Mill.var.spinosa (Bunge) Huex H.F.Chou.Time of the year when autumn changes into winter gathers mature fruit, removing sarcocarp and nucleocapsid, collects seed, dries.How wildly having another name called sour jujube, sour jujube, wild Fructus Jujubae, Fructus Choerospondiatis, Pueraria lobota pin etc., is often shrub, and what also have is dungarunga.Tree vigo(u)r is stronger.The form of branch, leaf, flower is similar to common Fructus Jujubae, but branch internode is shorter, and care thorn is flourishing, and except growth branch respectively saves except equal tool care thorn, fruitful branch stipule also becomes tapering care thorn.The small and dense life of leaf, little, many circles of fruit or ellipse, peel are thick, smooth, purplish red or puce, interior thin, taste is mostly very sour, and core circle or oval, core face is more smooth, includes 1 to 2 piece, seed.Nature and flavor-Gan, acid, flat, attending effectiveness: tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Rhizoma Corydalis: Rhizoma Corydalis has another name called Rhizoma Corydalis, Rhizoma Corydalis is Papaveraceae Corydalis herbaceos perennial, has yellow juice to flow out after stem fractures.Leaf alternate, there is incising of differing in size on full edge or top.Raceme top raw or with leaf to life, flower aubergine or green white, Length discrepancy, fruit Long Circle.Nature and flavor-Wen, pungent, bitter, attending effectiveness: invigorate blood circulation, promoting the circulation of QI, pain relieving, for the breast side of body, wrist abdomen pain.
Radix Gentianae: this product is the dry root and rhizome of gentianaceae plant Gentiana manshurica Gentiana manshurica Kitag., Radix Gentianae Gentianascabra Bunge, G. triflora Gentiana triflora pall or Gentiana rigescens Franch Gentiana rigescens Franch..First three is planted to practise and claims " Radix Gentianae ", and rear one is practised and claimed " Gentiana rigescens Franch ".Spring, Qiu Erji excavate, cleaning, drying.Another name: Radix Gentianae, Radix Gentianae, Radix Gentianae, nature and flavor-hardship, cold.Attending effectiveness: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms.
At present, Radix Bupleuri, Fructus Aurantii, the Radix Paeoniae Alba, Radix Glycyrrhizae, Herba Lysimachiae, Herba Artemisiae Scopariae, Semen Glycines, Semen Ziziphi Spinosae, Rhizoma Corydalis, Radix Gentianae is utilized.Interaction, composition of prescription, for the preparation for the treatment of chronic cholecystitis medicine, there is not been reported.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, and the method that the people usually adopted in the art know comprises the steps:
1) raw material is taken by following weight proportion: Radix Bupleuri 150 ~ 200 parts, Fructus Aurantii 100 ~ 200 parts, the Radix Paeoniae Alba 80 ~ 100 parts, 30 ~ 60 parts, Radix Glycyrrhizae, Herba Lysimachiae 200 ~ 250 parts, Herba Artemisiae Scopariae 200 ~ 300 parts, Semen Glycines 800 ~ 1000 parts, Semen Ziziphi Spinosae 800 ~ 1000 parts, Rhizoma Corydalis 80 ~ 100 parts, Radix Gentianae 80 ~ 100 parts;
2) except Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, all the other components decoct with water twice, and first time adds 3 times amount soak by water 3 hours, and second time adds 2 times amount soak by water 2 hours, collecting decoction, filter, are condensed into thick paste, for subsequent use;
3) get Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, add 6 times amount 70% alcohol heating reflux secondaries, each 1 hour, filter; Merging filtrate, reclaims ethanol and is condensed into thick paste, merging with above-mentioned thick paste;
4) drying under reduced pressure, is ground into fine powder, adds appropriate amount of auxiliary materials, and mixing, by tabletted after 75% alcohol granulation, or is filled in capsule; Its sheet also can sugar coating or film-coat, or is incapsulated by granule, obtains plain sheet, coated tablet, Film coated tablets, hard capsule dosage form.
Beneficial effect
A kind of Chinese medicine preparation and preparation method for the treatment of chronic cholecystitis of the present invention, to treat chronic, acute or subacute cholecystitis for main, has medicine and the analgesic drug product of heat-clearing and toxic substances removing concurrently simultaneously; The function of taking stopgap measures of reducing swelling and alleviating pain; The function of effecting a permanent cure of strengthening the spleen and nourishing the stomach, nourishing liver and gall can also be played simultaneously.Therefore, Chinese medicine preparation of the present invention possesses treating both the principal and secondary aspects of a disease, stable dose components, taking convenience, has no side effect.
Detailed description of the invention
The detailed description of the invention of form by the following examples, is described in further detail foregoing of the present invention.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1
Treat a Chinese medicine preparation for chronic cholecystitis, be made up of according to weight proportion following raw material components: Radix Bupleuri 15g, Fructus Aurantii 12g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 6g, Herba Lysimachiae 25g, Herba Artemisiae Scopariae 30g, Semen Glycines 100g, Semen Ziziphi Spinosae 100g, Rhizoma Corydalis 10g, Radix Gentianae 10g.
Preparation method, described step is as follows:
1) by above-mentioned raw material of Chinese medicine component, except Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, all the other components decoct with water twice, and first time adds 3 times amount soak by water 3 hours, and second time adds 2 times amount soak by water 2 hours, collecting decoction, filter, are condensed into thick paste, for subsequent use;
2) get Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, add 6 times amount 70% alcohol heating reflux secondaries, each 1 hour, filter; Merging filtrate, reclaims ethanol and is condensed into thick paste, merging with above-mentioned thick paste;
3) drying under reduced pressure, is ground into fine powder, adds appropriate amount of auxiliary materials, and mixing, by tabletted after 75% alcohol granulation.
Instructions of taking: each serving with 3, sooner or later respectively take 1 time after meal, take 3 weeks (3 course for the treatment of Monday) continuously.Period in a medicine, the food of greasy, meat or fish one class of edible oil, is not advisable with vegetarian diet.
Embodiment 2
Treat a Chinese medicine preparation for chronic cholecystitis, be made up of according to weight proportion following raw material components: Radix Bupleuri 18g, Fructus Aurantii 15g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 7g, Herba Lysimachiae 30g, Herba Artemisiae Scopariae 35g, Semen Glycines 100g, Semen Ziziphi Spinosae 100g, Rhizoma Corydalis 15g, Radix Gentianae 15g.
Preparation method, described step is as follows:
1) by above-mentioned raw material of Chinese medicine component, except Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, all the other components decoct with water twice, and first time adds 3 times amount soak by water 3 hours, and second time adds 2 times amount soak by water 2 hours, collecting decoction, filter, are condensed into thick paste, for subsequent use;
2) get Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, add 6 times amount 70% alcohol heating reflux secondaries, each 1 hour, filter; Merging filtrate, reclaims ethanol and is condensed into thick paste, merging with above-mentioned thick paste;
3) drying under reduced pressure, is ground into fine powder, adds appropriate amount of auxiliary materials, and mixing, is pressed into capsule with after 75% alcohol granulation.
Instructions of taking: each serving with 3, sooner or later respectively take 1 time after meal, take 3 weeks (3 course for the treatment of Monday) continuously.Period in a medicine, the food of greasy, meat or fish one class of edible oil, is not advisable with vegetarian diet.
Embodiment 3
Treat a Chinese medicine preparation for chronic cholecystitis, be made up of according to weight proportion following raw material components: Radix Bupleuri 15g, Fructus Aurantii 15g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 8g, Herba Lysimachiae 25g, Herba Artemisiae Scopariae 25g, Semen Glycines 90g, Semen Ziziphi Spinosae 90g, Rhizoma Corydalis 12g, Radix Gentianae 12g.
Preparation method, described step is as follows:
1) by above-mentioned raw material of Chinese medicine component, except Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, all the other components decoct with water twice, and first time adds 3 times amount soak by water 3 hours, and second time adds 2 times amount soak by water 2 hours, collecting decoction, filter, are condensed into thick paste, for subsequent use;
2) get Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, add 6 times amount 70% alcohol heating reflux secondaries, each 1 hour, filter; Merging filtrate, reclaims ethanol and is condensed into thick paste, merging with above-mentioned thick paste;
3) drying under reduced pressure, is ground into fine powder, adds appropriate amount of auxiliary materials, mixing, by tabletted rear after 75% alcohol granulation, or is filled in capsule; Its sheet also can sugar coating or film-coat, or is incapsulated by granule, obtains plain sheet, coated tablet, Film coated tablets, hard capsule dosage form.
Instructions of taking: each serving with 3, sooner or later respectively take 1 time after meal, take 3 weeks (3 course for the treatment of Monday) continuously.Period in a medicine, the food of greasy, meat or fish one class of edible oil, is not advisable with vegetarian diet.
There are following case below, confirm its curative effect:
1, health, 30 years old, July 25 in 2005 is through local people's examination in hospital out cholecystitis (chronic), Symptoms was right Upper abdominal pain, the frequent persistence distending pain of Nausea and vomiting at that time, take the medicament prepared by the embodiment of the present invention 1 afterwards, after taking medicine one week, right Upper abdominal pain obviously alleviates, do not occur Nausea and vomiting phenomenon, the state of an illness is clearly better.
2, section, 40 years old, gallbladder occurred that congestion and edema was obvious at that time, and the wall thickness of gallbladder or gallbladder tube wall, crude, entrant sound all exceed normal range value.Take the medicament prepared by the embodiment of the present invention 2, after taking medicine latter four days, appetite of receiving increases, complexion takes a turn for the better, and epigastrium pain relief, after continuing to take 1 one weeks, owe smooth through ultrasonic display gallbladder wall < 0.3cm, gallbladder wall, clinical symptoms obviously alleviates.Take 3 weeks continuously, clinical symptoms disappears completely, does not recur after following up a case by regular visits to 1 year.
3, Wang, 33 years old, on October 9th, 2009, suffer from acute cholecystitis, show as tension of abdominal muscle, tenderness, rebound tenderness in the middle part of the visible right upper quadrant of the abdomen of abdomen examination and upper abdomen, ultrasonic examination was done immediately at that time, gallbladder wall > 0.4cm, inner wall coarse in hospital.Take the medicament prepared by the embodiment of the present invention 3, after taking medicine one week, owe smooth through ultrasonic display gallbladder wall < 0.3cm, gallbladder wall, clinical symptoms obviously alleviates.Take 3 weeks continuously, return to one's perfect health.
At present, with a kind of Chinese medicine preparation for the treatment of chronic cholecystitis of the present invention, treatment associated patient more than 200 example, effective percentage is 92%.
Claims (3)
1. treat a Chinese medicine preparation for chronic cholecystitis, it is characterized in that: configured by each raw material of following weight Chinese medicine and form: Radix Bupleuri 150 ~ 200 parts, Fructus Aurantii 100 ~ 200 parts, the Radix Paeoniae Alba 80 ~ 100 parts, 30 ~ 60 parts, Radix Glycyrrhizae, Herba Lysimachiae 200 ~ 250 parts, Herba Artemisiae Scopariae 200 ~ 300 parts, Semen Glycines 800 ~ 1000 parts, Semen Ziziphi Spinosae 800 ~ 1000 parts, Rhizoma Corydalis 80 ~ 100 parts, Radix Gentianae 80 ~ 100 parts.
2. the Chinese medicine preparation for the treatment of chronic cholecystitis according to claim 1, is characterized in that: each parts by weight of raw materials proportioning of Chinese medicine is: Radix Bupleuri 150 parts, Fructus Aurantii 120 parts, the Radix Paeoniae Alba 80 parts, 30 parts, Radix Glycyrrhizae, Herba Lysimachiae 200 parts, Herba Artemisiae Scopariae 300 parts, Semen Glycines 800 parts, Semen Ziziphi Spinosae 800 parts, Rhizoma Corydalis 100 parts, Radix Gentianae 100 parts.
3. the Chinese medicine preparation for the treatment of chronic cholecystitis according to claim 1 and preparation method, is characterized in that the method comprises the steps:
1) by each for Chinese medicine according to claim 1 raw material, except Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, all the other components decoct with water twice, first time adds 3 times amount soak by water 3 hours, and second time adds 2 times amount soak by water 2 hours, collecting decoction, filter, be condensed into thick paste, for subsequent use;
2) get Herba Lysimachiae, Rhizoma Corydalis, Radix Gentianae, add 6 times amount 70% alcohol heating reflux secondaries, each 1 hour, filter; Merging filtrate, reclaims ethanol and is condensed into thick paste, merging with above-mentioned thick paste;
3) drying under reduced pressure, is ground into fine powder, adds appropriate amount of auxiliary materials, and mixing, by tabletted after 75% alcohol granulation, or is filled in capsule; Its sheet also can sugar coating or film-coat, or is incapsulated by granule, obtains plain sheet, coated tablet, Film coated tablets, hard capsule dosage form.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304730A (en) * | 2000-07-25 | 2001-07-25 | 刘兰荣 | Chinese medicine for treating cholecystitis |
| CN102872261A (en) * | 2012-09-26 | 2013-01-16 | 济南星懿医药技术有限公司 | Application of straw berry tomato in preparing medicine for treating acute cholecystitis |
-
2015
- 2015-03-16 CN CN201510121153.6A patent/CN104740009A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304730A (en) * | 2000-07-25 | 2001-07-25 | 刘兰荣 | Chinese medicine for treating cholecystitis |
| CN102872261A (en) * | 2012-09-26 | 2013-01-16 | 济南星懿医药技术有限公司 | Application of straw berry tomato in preparing medicine for treating acute cholecystitis |
Non-Patent Citations (2)
| Title |
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| 王淑贞，刘恒太: "疏肝利胆法在胆囊炎中的运用", 《江西中医药》 * |
| 赵恒志等: "自拟消炎利胆汤治疗慢性胆囊炎60例", 《国医论坛》 * |
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