CN103055078B - Traditional Chinese medicine for treating ascites hepatoma and preparation method thereof - Google Patents
Traditional Chinese medicine for treating ascites hepatoma and preparation method thereof Download PDFInfo
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- CN103055078B CN103055078B CN201210573538.2A CN201210573538A CN103055078B CN 103055078 B CN103055078 B CN 103055078B CN 201210573538 A CN201210573538 A CN 201210573538A CN 103055078 B CN103055078 B CN 103055078B
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Abstract
The invention aims to provide a traditional Chinese medicine for treating ascites hepatoma and a preparation method thereof. The traditional Chinese medicine comprises the following raw materials: plantago, Chinese lobelia herb, areca peel, euphorbia helioscopia, motherwort, morning glory seed, solanum nigrum, cassia twig, cowherb seed, milkvetch root, manchurian wildginger, etc. The traditional Chinese medicine provided by the invention employs the reasonably combined raw materials to achieve the effects of rectifying qi, warming yang, removing blood stasis, transforming turbidity, supporting right and dispelling evil together. A therapeutic method for the traditional Chinese medicine is easy and convenient, and the traditional Chinese medicine has steady medicine properties and comprehensive action, is safe and reliable, enables a patient to be increasingly better and improves quality of the life of the patient.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to Chinese medicine of a kind of Hepatoma therapy ascites and preparation method thereof.
Background technology
Hepatic ascites is one of modal complication of advanced liver cancer, liver cancer patient occurs that ascites is mainly that albumin is synthetic to be reduced because chronic liver function damage makes, plasma colloid osmotic pressure declines or the quiet high pressure of door causes the inside and outside water liquid metabolic imbalance of cell, and intracellular water liquid runs off and forms ascites to extracellular.The symptoms such as hepatic ascites patient Chang Hui shows as dry mouth and throat, thirsty.Hepatic ascites not only increases patient's misery, and severe patient can threaten patient's life.
For the treatment of hepatic ascites, should carry out for the cause of disease.So to shift the hepatic ascites anticancer transfer in time causing due to liver cancer cellular invasion, and improve in time patient's immunologic function, better resist cancerous protuberance and occur.Should treat in time liver cirrhosis for the hepatic ascites causing due to cirrhotic complications, prevent that ascites from growing.But generally speaking, the reason of the generation maximum of hepatic ascites is hepatic injury, therefore also should reasonably apply for the medicine with the effect of reparation liver function.
The treatment of hepatic ascites, doctor trained in Western medicine adopts the treatment of drawing water conventionally, cures the symptoms, not the disease often, ascites is shown effect repeatedly, the fundamentally regeneration of ascites has always increased very large misery to patient on the contrary in each therapeutic process, and therefore western medical treatment hepatic ascites is not best method.Chinese traditional treatment hepatic ascites adopts the method for determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and toxic and side effects is less, and currently available technology has some researchs and trial, but lacks systematic research, and therapeutic effect is clear and definite not.
Hepatic ascites is one of modal complication of advanced liver cancer, the formation of hepatic ascites is on the basis of hepatocarcinoma, belong to the one of malignant ascite, the appearance of hepatic ascites symptom is having a strong impact on the quality of life of vast liver cancer patient, also the difficulty that has increased mid and late liver cancer treatment, therefore effective treatment of hepatic ascites is very important simultaneously.
Summary of the invention
The object of this invention is to provide Chinese medicine of a kind of Hepatoma therapy ascites and preparation method thereof, the Chinese medicine of Hepatoma therapy ascites provided by the present invention is Hepatoma therapy ascites preferably, has no side effect, safe and reliable.
The Chinese medicine of Hepatoma therapy ascites of the present invention is to be prepared from by the raw material that comprises following weight portion:
Herba Plantaginis 20～80 Herba Lobeliae Chinensis 10～50 Pericarpium Arecae 5～40 Herba Euphorbiae Helioscopiae 10～50
Herba Leonuri 5～40 Semen Pharbitidis 2～30 Herba Solani Nigri 2～30 Ramulus Cinnamomi 2～30
Semen Vaccariae 2～30 Radix Astragali 30～90 Herba Asaris 2～30.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its preferred version is to be prepared from by the raw material that comprises following weight portion:
Herba Plantaginis 40～70 Herba Lobeliae Chinensis 20～40 Pericarpium Arecae 10～30 Herba Euphorbiae Helioscopiae 20～40
Herba Leonuri 10～30 Semen Pharbitidis 5～20 Herba Solani Nigri 5～20 Ramulus Cinnamomi 5～20
Semen Vaccariae 5～20 Radix Astragali 40～80 Herba Asaris 5～20.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Herba Plantaginis 50 Herba Lobeliae Chinensis 30 Pericarpium Arecae 20 Herba Euphorbiae Helioscopiae 30
Herba Leonuri 20 Semen Pharbitidis 10 Herba Solani Nigri 10 Ramulus Cinnamomi 10
Semen Vaccariae 10 Radix Astragali 60 Herba Asaris 10.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its active component is prepared from by the following method:
Get whole 11 taste medical materials, extracting in water twice, adds the water that is equivalent to 4～10 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 4～10 times of medical material gross weights, extracts 1～2 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 DEG C, relative density is 1.20～1.25, adding ethanol to the concentration of volume percent containing alcohol amount is 50%～60%, stir even, leave standstill 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.20～1.25, obtains described active component.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its active component is to be prepared from by following method for optimizing:
Get whole 11 taste medical materials, extracting in water twice, adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 6～8 times of medical material gross weights, extracts 1.5 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 DEG C, relative density is 1.23, adding ethanol to the concentration of volume percent containing alcohol amount is 55%, stir even, leave standstill 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.23, obtains described active component.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its active component can also be prepared from by another following method for optimizing:
Get whole 11 taste medical materials, add and be equivalent to the alcohol dipping 12～48 hours that the volume by volume concentration of 1～2 times of this 11 taste medical material gross weight is 40%～60%, then the ethanol that is 40%～60% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.2%～0.6% per minute, collection is equivalent to the percolate that this 11 taste medical material gross weight 5-10 doubly measures, and obtains active component.
The Chinese medicine of Hepatoma therapy ascites of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms.
In the present invention, Chinese medicine details is as follows:
Herba Plantaginis
This product is the dry herb of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd Plantago depressa Willd..Excavate summer, removes silt, dries.Sweet in the mouth, cold in nature.Return liver, kidney, lung, small intestine meridian.Function clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances.For edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Herba Lobeliae Chinensis
This product is the dry herb of Campanulaceae Herba Lobeliae Chinensis Lobelia chinensis Lour..Gather summer, removes silt, cleans, and dries.Acrid in the mouth, property is flat.GUIXIN, small intestinal, lung meridian.Function heat-clearing and toxic substances removing, inducing diuresis to remove edema.For carbuncle furuncle, snake bite and insect sting, tympanites edema, jaundice due to damp-heat, eczema eczema.
Pericarpium Arecae
This product is the dry peel of babassu Semen Arecae Areca catechu L..Winter to time spring green fruit of gathering, boils rear dryly, and vertical profile two lobes, strip peel, practise and claim " Pericarpium Arecae "; The mature fruit of gathering at the beginning of spring end to autumn, boils rear dryly, strips peel, beats pine, dries, and practises title " PERICARPIUM ARECAE ".Acrid in the mouth, slightly warm in nature.Return spleen, stomach, large intestine, small intestine meridian.Function therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, gastral cavity abdominal distention is vexed, defecate not well, and edema distension, beriberi edema, dysuria.
Herba Euphorbiae Helioscopiae
This product is the dry herb of dicotyledon Euphorbiaceae Euphorbiaceae Herba Euphorbiae Helioscopiae Euphorbia helioscopiaL..Acrid in the mouth, hardship, cold nature; Poisonous.Return large intestine, small intestinal, lung meridian.Function inducing diuresis to remove edema, dissipating phlegm and resolving masses, killing parasites for relieving itching.For ascites, edema, pulmonary tuberculosis, the tuberculosis of cervical lymph nodes, abundant expectoration breath with cough, tinea skin ulcer.
Herba Leonuri
This product is the fresh or dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..Fresh goods Seedling Stage in spring to first summer flower is tapped early stage; Dry product stem and leaf in summer is luxuriant, Hua Weikai or tap while just opening, dry, or cutting is dried.Bitter in the mouth, pungent, cold nature.Return liver, pericardium channel.Function promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Semen Pharbitidis
This product is the dry mature seed of convolvulaceous plant pharbitis nilChoisy Pharbitis nil (L.) Choisy or Pharbitis purpurea Pharbitis purpurea (L.) Voigt.Autumn Mo is tapped plant when fruit maturation, shell do not ftracture, and dries, and lays seed, removes impurity.Bitter in the mouth, cold in nature; Poisonous.Return lung, kidney, large intestine channel.The relieving constipation of function removing water retention by purgation, drink is washed in expectorant, and parasite killing is attacked long-pending.For edema distension, constipation and anuresis, phlegm retention is gathered, and QI rising in reverse order is breathed with cough, abdominal pain due to worm stagnation.
Herba Solani Nigri
This product be plant of Solanaceae Herba Solani Nigri Solanum nigrum L. herb.Summer, autumn tap, and remove impurity, dry.Bitter in the mouth, cold in nature, slightly poisonous.Function heat-clearing and toxic substances removing, inducing diuresis to remove edema.For cat fever, toothache, chronic bronchitis, acute nephritis, dysentery, urinary system infection, mastitis, leucorrhea, cancer; Carbuncle furuncle furuncle, pemphigus, injury from falling down, venom are controlled in external.
Ramulus Cinnamomi
This product is the dry twig of canella Cortex Cinnamomi CinnamomumcassiaPresl.Spring, Xia Erji gather, and except defoliation, dry, or section are dried.Acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.Function diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Semen Vaccariae
This product is pinkwort Vaccaria segetalis Vaccariasegetalis(neck) dry mature seed of Garcker.Tap plant when fruit maturation, peel not yet ftracture summer, dries, and lays seed, removes impurity, then dry.Bitter in the mouth, property is flat.Return liver, stomach warp.Function promoting blood circulation to restore menstrual flow, stimulating milk secretion detumescence, inducing diuresis for treating stranguria syndrome.For amenorrhea, dysmenorrhea, agalactia, acute mastitis swells and ache, the puckery pain of stranguria.
The Radix Astragali
This product is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Spring, Qiu Erji excavate, and remove fibrous root and root head, dry.Sweet in the mouth, warm in nature.Return lung, spleen channel.Function invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Herba Asari
This product is the dry herb of aristolochiaceae plant Herba Asari Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag., Seoul Herba Asari Asarum sieboldii Miq. f.seoulense (Nak.) C.Y. Cheng et C.S. Yang or magnificent Herba Asari Asarum sieboldii Miq..The first two is planted to practise and claims " Herba Asari ".Summer fructescence or early autumn excavate, and Ex-all aerial parts and silt, dry in the shade.Acrid in the mouth, warm in nature.GUIXIN, lung, kidney channel.Function expelling wind and cold, wind-expelling pain-stopping, sensible, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
The present invention finds out on to the understanding of hepatic ascites basic pathogenesis.The basic pathogenesis of hepatic ascites is: deficiency of spleen-YANG damages, and the noxious dampness stasis of blood is stagnant, functional activity of QI being not smooth.Herba Plantaginis of the present invention, Herba Lobeliae Chinensis two medicines all have heat-clearing and toxic substances removing, the effect of inducing diuresis to remove edema, and Herba Lobeliae Chinensis is medicine first choice of the differential diagnosis of diseases medication for the treatment of malignant ascite, and Herba Euphorbiae Helioscopiae is the key medicine of anticancer diuretic, can powerful row water, there is again anticancer and don't wound effect just, Herba Leonuri blood circulation promoting and blood stasis dispelling diuretic, the relieving constipation of Semen Pharbitidis removing water retention by purgation, drink is washed in expectorant, can tonneau internal organs gas, the turbid detumescence of dispelling again.Pericarpium Arecae therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence, Herba Solani Nigri is used for the treatment of the dysuria that edema causes.The patient of hepatic ascites tends to stagnation of blood stasis, deficiency of YIN affecting YANG, and we pay attention to the strength of QI invigorating and body resistance strengthening in diuretic, therefore with the Radix Astragali, Ramulus Cinnamomi, Semen zanthoxyli warming YANG to promote diuresis, QI invigorating and body resistance strengthening, is not just hindering diuretic, the not effect of removing blood stasis of invigorating blood circulation.The capable water of Herba Asari cold expelling, warming YANG pain relieving.Medicine collocation of the present invention rationally, reaches the warming YANG of regulating the flow of vital energy jointly, and blood stasis dispellingization is turbid, the effect of strengthening vital QI to eliminate pathogenic factors.Therapeutic Method of the present invention is easy, and the property of medicine is steady, and effect comprehensively.
As the clinical test results of embodiment 7 and embodiment 8 shows, Chinese medicine of the present invention can use separately Hepatoma therapy ascites, has good effect, and effective percentage reaches 87%; And in the clinical process treating, have no toxic and side effects, safe and reliable, can make conditions of patients constantly take a turn for the better, improve greatly patient's life quality.
Chinese medicine provided by the invention has overcome the defect of prior art, has outstanding substantive distinguishing features and progressive significantly with respect to prior art.
Detailed description of the invention
Embodiment 1
Herba Plantaginis 200g Herba Lobeliae Chinensis 100g Pericarpium Arecae 50g Herba Euphorbiae Helioscopiae 100g
Herba Leonuri 50g Semen Pharbitidis 20g Herba Solani Nigri 20g Ramulus Cinnamomi 20g
Semen Vaccariae 20g Radix Astragali 300g Herba Asari 20g
Get whole 11 taste medical materials, extracting in water twice, adds the water of 3600g for the first time, extracts 1 hour, adds for the second time the water of 3600g, extracts 1 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 DEG C, relative density is 1.20, adding ethanol to the concentration of volume percent containing alcohol amount is 50%, stir even, leave standstill 12 hours, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.20, obtains described active component.
Embodiment 2
Herba Plantaginis 800g Herba Lobeliae Chinensis 500g Pericarpium Arecae 400g Herba Euphorbiae Helioscopiae 500g
Herba Leonuri 400g Semen Pharbitidis 300g Herba Solani Nigri 300g Ramulus Cinnamomi 300g
Semen Vaccariae 300g Radix Astragali 900g Herba Asari 300g
Get whole 11 taste medical materials, extracting in water twice, adds the water of 50000g for the first time, extracts 3 hours, adds for the second time the water of 50000g, extracts 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 DEG C, relative density is 1.25, adding ethanol to the concentration of volume percent containing alcohol amount is 60%, stir even, leave standstill 24 hours, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.25, obtains described active component.
Active component is mixed homogeneously with appropriate antioxidant, propellant, obtain aerosol of the present invention.
Embodiment 3
Herba Plantaginis 400g Herba Lobeliae Chinensis 200g Pericarpium Arecae 100g Herba Euphorbiae Helioscopiae 200g
Herba Leonuri 100g Semen Pharbitidis 50g Herba Solani Nigri 50g Ramulus Cinnamomi 50g
Semen Vaccariae 50g Radix Astragali 400g Herba Asari 50g.
Get whole 11 taste medical materials, be ground into fine powder, cross 80 mesh sieves, mix homogeneously, obtains powder agent of the present invention.
Embodiment 4
Herba Plantaginis 500g Herba Lobeliae Chinensis 300g Pericarpium Arecae 200g Herba Euphorbiae Helioscopiae 300g
Herba Leonuri 200g Semen Pharbitidis 100g Herba Solani Nigri 100g Ramulus Cinnamomi 100g
Semen Vaccariae 100g Radix Astragali 600g Herba Asari 100g.
Get whole 11 taste medical materials, extracting in water twice, adds the water of 20800g for the first time, extracts 2 hours, adds for the second time the water of 15600g, extracts 1.5 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 DEG C, relative density is 1.23, adding ethanol to the concentration of volume percent containing alcohol amount is 55%, stir even, leave standstill 18 hours, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.23, obtains described active component.
Active component is coordinated with appropriate water-soluble base, stir, obtain ointment of the present invention.
Embodiment 5
Herba Plantaginis 400g Herba Lobeliae Chinensis 400g Pericarpium Arecae 300g Herba Euphorbiae Helioscopiae 400g
Herba Leonuri 300g Semen Pharbitidis 200g Herba Solani Nigri 200g Ramulus Cinnamomi 200g
Semen Vaccariae 200g Radix Astragali 400g Herba Asari 200g
Get whole 11 taste medical materials, extracting in water twice, adds the water of 16000g for the first time, extracts 2.5 hours, adds for the second time the water of 19200g, extracts 1.8 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 DEG C, relative density is 1.24, adding ethanol to the concentration of volume percent containing alcohol amount is 53%, stir even, leave standstill 14 hours, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.22, obtains described active component.
Active component adds the adjuvants such as appropriate adhesive, wetting agent, filler, stirs, and coats on back lining materials, obtains gel rubber plaster unguentum of the present invention.
Embodiment 6
Herba Plantaginis 200g Herba Lobeliae Chinensis 300g Pericarpium Arecae 200g Herba Euphorbiae Helioscopiae 100g
Herba Leonuri 300g Semen Pharbitidis 230g Herba Solani Nigri 230g Ramulus Cinnamomi 230g
Semen Vaccariae 230g Radix Astragali 40g Herba Asari 60g
Get whole 11 taste medical materials, the alcohol dipping that the volume by volume concentration that adds 3180g is 60% 24 hours, the ethanol that is then 53% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.3% per minute, collect the percolate of 16960g, stir, filter, obtain tincture of the present invention.
Embodiment 7
The clinical trial situation of Chinese medicine of the present invention:
Case selection: random Hepatoma therapy ascites 30 examples;
Therapeutic Method: take the Chinese medicine of the embodiment of the present invention 4, once a day, by the medicine coating SHENQUE acupoint that is equivalent to crude drug amount 40g, stick about 3 hours at every turn.
Table 1 is treated clinical efficacy data
| ? | Number of cases | Clinical effective | Clinical effective | Invalid | Total effective rate |
| Embodiment 4 medicines | 30 | 17 | 9 | 4 | 87% |
Embodiment 8
1, Bian, female, 77 years old, diagnosing liver cancer 3 years, disease is seen epigastrium distending pain, is persistence, the sign of ascites positive, poor appetite, dimly red tongue, white and thin fur, stringy pulse.Treat through medicine of the present invention, after one week, conscious urine is increased, abdominal part distension pain relief.
2, Gong, man, 51 years old, be diagnosed as primary hepatocarcinoma, disease is seen abdominal distention, right flank portion pain, persistence distending pain, without fever with aversion to cold, poor appetite, soft tired power, oliguria.Treat through medicine of the present invention, abdominal distention alleviates, and urine is increased, and appetite increases.
3, Zhao, female, 61 years old, is diagnosed as primary hepatocarcinoma.Disease is seen epigastrium distending pain discomfort, poor appetite, and appearance xanthochromia, sleep poor night, and yellow urine is few, and two lower limbs edema give after Drug therapy of the present invention, and abdominal distention alleviates, and urine is increased.
Claims (7)
1. a Chinese medicine for Hepatoma therapy ascites, is characterized in that it is to be prepared from by the raw material of following weight portion:
Herba Plantaginis 20～80 Herba Lobeliae Chinensis 10～50 Pericarpium Arecae 5～40 Herba Euphorbiae Helioscopiae 10～50
Herba Leonuri 5～40 Semen Pharbitidis 2～30 Herba Solani Nigri 2～30 Ramulus Cinnamomi 2～30
Semen Vaccariae 2～30 Radix Astragali 30～90 Herba Asaris 2～30.
2. the Chinese medicine of Hepatoma therapy ascites as claimed in claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion:
Herba Plantaginis 40～70 Herba Lobeliae Chinensis 20～40 Pericarpium Arecae 10～30 Herba Euphorbiae Helioscopiae 20～40
Herba Leonuri 10～30 Semen Pharbitidis 5～20 Herba Solani Nigri 5～20 Ramulus Cinnamomi 5～20
Semen Vaccariae 5～20 Radix Astragali 40～80 Herba Asaris 5～20.
3. the Chinese medicine of Hepatoma therapy ascites as claimed in claim 2, is characterized in that it is to be prepared from by the raw material of following weight portion:
Herba Plantaginis 50 Herba Lobeliae Chinensis 30 Pericarpium Arecae 20 Herba Euphorbiae Helioscopiae 30
Herba Leonuri 20 Semen Pharbitidis 10 Herba Solani Nigri 10 Ramulus Cinnamomi 10
Semen Vaccariae 10 Radix Astragali 60 Herba Asaris 10.
4. the Chinese medicine of Hepatoma therapy ascites as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 11 taste medical materials, extracting in water twice, adds the water that is equivalent to 4～10 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 4～10 times of medical material gross weights, extracts 1～2 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 DEG C, relative density is 1.20～1.25, adding ethanol to the concentration of volume percent containing alcohol amount is 50%～60%, stir even, leave standstill 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.20～1.25, obtains described active component.
5. the Chinese medicine of Hepatoma therapy ascites as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 11 taste medical materials, extracting in water twice, adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 6～8 times of medical material gross weights, extracts 1.5 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 DEG C, relative density is 1.23, adding ethanol to the concentration of volume percent containing alcohol amount is 55%, stir even, leave standstill 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.23, obtains described active component.
6. the Chinese medicine of Hepatoma therapy ascites as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 11 taste medical materials, add and be equivalent to the alcohol dipping 12～48 hours that the volume by volume concentration of 1～2 times of this 11 taste medicine gross weight is 40%～60%, then the ethanol that is 40%～60% with concentration of volume percent carries out percolation with the speed that accounts for raw material gross weight 0.2%～0.6% per minute, collection is equivalent to the percolate that this 11 taste medical material gross weight 5-10 doubly measures, and obtains active component.
7. a Chinese medicine preparation for Hepatoma therapy ascites, is made up of as active component and pharmaceutically acceptable carrier the Chinese medicine of the Hepatoma therapy ascites described in any one in claim 1～6.
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| CN108355067A (en) * | 2018-04-18 | 2018-08-03 | 陈茂华 | The Chinese medicine for the treatment of cancer ascites |
| CN111588827A (en) * | 2020-05-27 | 2020-08-28 | 袁希福 | Externally-applied diuresis promoting ointment for treating cancerous chest and ascites and preparation method thereof |
| CN114869961A (en) * | 2022-04-29 | 2022-08-09 | 贵州中医药大学 | Medicine for treating cancerous ascites and preparation method thereof |
Citations (1)
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| CN1422641A (en) * | 2001-12-05 | 2003-06-11 | 李佩文 | Medicine for treating cancerous thoracoascites and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1422641A (en) * | 2001-12-05 | 2003-06-11 | 李佩文 | Medicine for treating cancerous thoracoascites and preparation method |
Non-Patent Citations (2)
| Title |
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| 内金术茅汤治疗恶性腹腔积液56例;董明娥;《陕西中医》;20071231;第28卷(第4期);396-397 * |
| 董明娥.内金术茅汤治疗恶性腹腔积液56例.《陕西中医》.2007,第28卷(第4期),396-397. |
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