CN103055078A - Traditional Chinese medicine for treating ascites hepatoma and preparation method thereof - Google Patents
Traditional Chinese medicine for treating ascites hepatoma and preparation method thereof Download PDFInfo
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- CN103055078A CN103055078A CN2012105735382A CN201210573538A CN103055078A CN 103055078 A CN103055078 A CN 103055078A CN 2012105735382 A CN2012105735382 A CN 2012105735382A CN 201210573538 A CN201210573538 A CN 201210573538A CN 103055078 A CN103055078 A CN 103055078A
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Abstract
The invention aims to provide a traditional Chinese medicine for treating ascites hepatoma and a preparation method thereof. The traditional Chinese medicine comprises the following raw materials: plantago, Chinese lobelia herb, areca peel, euphorbia helioscopia, motherwort, morning glory seed, solanum nigrum, cassia twig, cowherb seed, milkvetch root, manchurian wildginger, etc. The traditional Chinese medicine provided by the invention employs the reasonably combined raw materials to achieve the effects of rectifying qi, warming yang, removing blood stasis, transforming turbidity, supporting right and dispelling evil together. A therapeutic method for the traditional Chinese medicine is easy and convenient, and the traditional Chinese medicine has steady medicine properties and comprehensive action, is safe and reliable, enables a patient to be increasingly better and improves quality of the life of the patient.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to Chinese medicine of a kind of Hepatoma therapy ascites and preparation method thereof.
Background technology
Hepatic ascites is one of modal complication of advanced liver cancer, it mainly is that albumin is synthetic to be reduced because chronic liver function damage makes that ascites appears in liver cancer patient, plasma colloid osmotic pressure descends or the quiet high pressure of door causes the inside and outside water liquid metabolic imbalance of cell, and intracellular water liquid runs off to the extracellular and forms ascites.The symptoms such as hepatic ascites patient Chang Hui shows as dry mouth and throat, and is thirsty.Hepatic ascites not only increases patient's misery, and severe patient can threaten patient's life.
For the treatment of hepatic ascites, should carry out for the cause of disease.So to the in time anticancer transfer of hepatic ascites that causes owing to the transfer of liver cancer cellular invasion, and in time improve patient's immunologic function, better resist cancerous protuberance and occur.For because the hepatic ascites that cirrhotic complications causes should in time be treated liver cirrhosis, prevent that ascites from growing.But generally speaking, the reason of the generation maximum of hepatic ascites is hepatic injury, therefore also should reasonably use for having the medicine of repairing the liver function effect.
The treatment of drawing water is adopted in the treatment of hepatic ascites, doctor trained in Western medicine usually, cures the symptoms, not the disease often, ascites is shown effect repeatedly, the fundamentally always regeneration of ascites has increased very large misery to the patient on the contrary in each therapeutic process, so the western medical treatment hepatic ascites is not best method.The Chinese traditional treatment hepatic ascites adopts the method for determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and toxic and side effects is less, and prior art has some researchs and trial at present, but lacks systematic research, and therapeutic effect is clear and definite not.
Hepatic ascites is one of modal complication of advanced liver cancer, the formation of hepatic ascites is on the basis of hepatocarcinoma, belong to a kind of of malignant ascite, the appearance of hepatic ascites symptom is having a strong impact on the quality of life of vast liver cancer patient, also increased simultaneously the difficulty of mid and late liver cancer treatment, so effective treatment of hepatic ascites is very important.
Summary of the invention
The purpose of this invention is to provide Chinese medicine of a kind of Hepatoma therapy ascites and preparation method thereof, the Chinese medicine of Hepatoma therapy ascites provided by the present invention is Hepatoma therapy ascites preferably, has no side effect, and is safe and reliable.
The Chinese medicine of Hepatoma therapy ascites of the present invention is to be prepared from by the raw material that comprises following weight portion:
Herba Plantaginis 20～80 Herba Lobeliae Chinensis 10～50 Pericarpium Arecae 5～40 Herba Euphorbiae Helioscopiae 10～50
Herba Leonuri 5～40 Semen Pharbitidiss 2～30 Herba Solani Nigris 2～30 Ramulus Cinnamomi 2～30
Semen Vaccariae 2～30 Radixs Astragali 30～90 Herba Asaris 2～30.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its preferred version are to be prepared from by the raw material that comprises following weight portion:
Herba Plantaginis 40～70 Herba Lobeliae Chinensis 20～40 Pericarpium Arecae 10～30 Herba Euphorbiae Helioscopiae 20～40
Herba Leonuri 10～30 Semen Pharbitidiss 5～20 Herba Solani Nigris 5～20 Ramulus Cinnamomi 5～20
Semen Vaccariae 5～20 Radixs Astragali 40～80 Herba Asaris 5～20.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Herba Plantaginis 50 Herba Lobeliae Chinensis 30 Pericarpium Arecae 20 Herba Euphorbiae Helioscopiae 30
Herba Leonuri 20 Semen Pharbitidiss 10 Herba Solani Nigris 10 Ramulus Cinnamomi 10
Semen Vaccariae 10 Radixs Astragali 60 Herba Asaris 10.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its active component is prepared from by the following method:
Get whole 11 flavor medical materials, extracting in water twice adds the water that is equivalent to 4～10 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 4～10 times of medical material gross weights, extracts 1～2 hour; Merge extractive liquid,, relative density is 1.20～1.25 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 50%～60%, stir even, left standstill 12～24 hours, filter, relative density was 1.20～1.25 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its active component are to be prepared from by following method for optimizing:
Get whole 11 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 6～8 times of medical material gross weights, extracts 1.5 hours; Merge extractive liquid,, relative density is 1.23 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 55%, stir and spare, left standstill 12～24 hours, filter, relative density was 1.23 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
The Chinese medicine of Hepatoma therapy ascites of the present invention, its active component can also be prepared from by another following method for optimizing:
Get whole 11 flavor medical materials, added the volume by volume concentration be equivalent to 1～2 times of this 11 flavor medical material gross weight and be 40%～60% alcohol dipping 12～48 hours, then be that 40%～60% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.2%～0.6% with volume by volume concentration, collection is equivalent to the percolate that this 11 flavor medical material gross weight 5-10 doubly measures, and obtains active component.
The Chinese medicine of Hepatoma therapy ascites of the present invention can cooperate with pharmaceutically acceptable carrier, makes various common dosage forms.
The Chinese medicine details is as follows among the present invention:
Herba Plantaginis
This product is the dry herb of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd Plantago depressa Willd..Excavate summer, removes silt, dries.Sweet in the mouth, cold in nature.Return liver, kidney, lung, small intestine meridian.The function clearing away heat and promoting diuresis is eliminated the phlegm, removing heat from blood, detoxifcation.Be used for the edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Herba Lobeliae Chinensis
This product is the dry herb of Campanulaceae Herba Lobeliae Chinensis Lobelia chinensis Lour..Gather summer, removes silt, cleans, and dries.Acrid in the mouth, property is flat.GUIXIN, small intestinal, lung meridian.The function heat-clearing and toxic substances removing, inducing diuresis to remove edema.Be used for the carbuncle furuncle, snake bite and insect sting, tympanites edema, jaundice due to damp-heat, eczema eczema.
Pericarpium Arecae
This product is the dry peel of babassu Semen Arecae Areca catechu L..Winter to time spring green fruit of gathering is boiled rear drying, and vertical profile two lobes strip peel, practise claiming " Pericarpium Arecae "; The mature fruit of gathering at the beginning of spring end to autumn is boiled rear drying, strips peel, beats pine, dries, and practises claiming " PERICARPIUM ARECAE ".Acrid in the mouth, slightly warm in nature.Return spleen, stomach, large intestine, small intestine meridian.Function therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.Be used for retention of damp leading to blockage of QI, gastral cavity abdominal distention is vexed, defecates not well edema distension, beriberi edema, dysuria.
Herba Euphorbiae Helioscopiae
This product is the dry herb of dicotyledon Euphorbiaceae Euphorbiaceae Herba Euphorbiae Helioscopiae Euphorbia helioscopiaL..Acrid in the mouth, hardship, cold nature; Poisonous.Return large intestine, small intestinal, lung meridian.The function inducing diuresis to remove edema, dissipating phlegm and resolving masses, killing parasites for relieving itching.Be used for that ascites, edema, pulmonary tuberculosis, the tuberculosis of cervical lymph nodes, abundant expectoration are breathed with cough, the tinea skin ulcer.
Herba Leonuri
This product is the fresh or dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..Fresh goods Seedling Stage in spring to first summer flower is tapped in earlier stage; Dry product stem and leaf in summer is luxuriant, Hua Weikai or tap when just opening, and dry, or cutting is dried.Bitter in the mouth, suffering, cold nature.Return liver, pericardium channel.The function promoting blood flow to regulate menstruation, inducing diuresis to remove edema.Be used for menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Semen Pharbitidis
This product is the dry mature seed of convolvulaceous plant pharbitis nilChoisy Pharbitis nil (L.) Choisy or Pharbitis purpurea Pharbitis purpurea (L.) Voigt.Autumn Mo fruit maturation, tap plant when shell does not ftracture, dry, lay seed, remove impurity.Bitter in the mouth, cold in nature; Poisonous.Return lung, kidney, large intestine channel.The relieving constipation of function removing water retention by purgation, drink is washed in expectorant, and parasite killing is attacked long-pending.Be used for the edema distension, constipation and anuresis, phlegm retention is gathered, and QI rising in reverse order is breathed with cough, abdominal pain due to worm stagnation.
Herba Solani Nigri
This product be plant of Solanaceae Herba Solani Nigri Solanum nigrum L. herb.Summer, autumn tap, and remove impurity, drying.Bitter in the mouth, cold in nature, slightly poisonous.The function heat-clearing and toxic substances removing, inducing diuresis to remove edema.Be used for cat fever, toothache, chronic bronchitis, acute nephritis, dysentery, urinary system infection, mastitis, leucorrhea, cancer; Carbuncle furuncle furuncle, pemphigus, injury from falling down, venom are controlled in external.
Ramulus Cinnamomi
This product is the dry twig of canella Cortex Cinnamomi CinnamomumcassiaPresl.Spring, Xia Erji gather, and except defoliation, dry, or section are dried.Acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.Function diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Semen Vaccariae
This product is pinkwort Vaccaria segetalis Vaccariasegetalis(neck) dry mature seed of Garcker.Summer fruit maturation, tap plant when peel not yet ftractures, dry, lay seed, remove impurity, dry again.Bitter in the mouth, property is flat.Return liver, stomach warp.The function promoting blood circulation to restore menstrual flow, stimulating milk secretion detumescence, inducing diuresis for treating stranguria syndrome.Be used for amenorrhea, dysmenorrhea, agalactia, acute mastitis swells and ache, the puckery pain of stranguria.
The Radix Astragali
This product is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Spring, Qiu Erji excavate, and remove fibrous root and root head, dry.Sweet in the mouth, warm in nature.Return lung, spleen channel.The function invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for the deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Herba Asari
This product is the dry herb of aristolochiaceae plant Herba Asari Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag., Seoul Herba Asari Asarum sieboldii Miq. f.seoulense (Nak.) C.Y. Cheng et C.S. Yang or magnificent Herba Asari Asarum sieboldii Miq..The first two is planted to practise and claims " Herba Asari ".Summer fructescence or early autumn excavate, and Ex-all aerial parts and silt dry in the shade.Acrid in the mouth, warm in nature.GUIXIN, lung, kidney channel.The function expelling wind and cold, wind-expelling pain-stopping, sensible, warming the lung to resolve fluid-retention.Be used for anemofrigid cold, headache, toothache, the nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
The present invention finds out in the understanding to the hepatic ascites basic pathogenesis.The basic pathogenesis of hepatic ascites is: deficiency of spleen-YANG decreases, and the noxious dampness stasis of blood stagnates, functional activity of QI being not smooth.Herba Plantaginis of the present invention, Herba Lobeliae Chinensis two medicines all have heat-clearing and toxic substances removing, the effect of inducing diuresis to remove edema, and Herba Lobeliae Chinensis is medicine first choice of the differential diagnosis of diseases medication for the treatment of malignant ascite, and Herba Euphorbiae Helioscopiae is the key medicine of anticancer diuretic, can powerful row water, have again anticancer and don't wound effect just, Herba Leonuri blood circulation promoting and blood stasis dispelling diuretic, the relieving constipation of Semen Pharbitidis removing water retention by purgation, drink is washed in expectorant, can tonneau internal organs gas, the turbid detumescence of dispelling again.Pericarpium Arecae therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence, Herba Solani Nigri is used for the treatment of the dysuria that edema causes.The patient of hepatic ascites tends to stagnation of blood stasis, deficiency of YIN affecting YANG, and we pay attention to the strength of QI invigorating and body resistance strengthening in diuretic, therefore with the Radix Astragali, Ramulus Cinnamomi, Semen zanthoxyli warming YANG to promote diuresis, QI invigorating and body resistance strengthening is not so that diuretic is just being hindered the not effect of removing blood stasis of invigorating blood circulation.The capable water of Herba Asari cold expelling, the warming YANG pain relieving.Medicine collocation of the present invention rationally reaches the warming YANG of regulating the flow of vital energy jointly, and blood stasis dispellingization is turbid, the effect of strengthening vital QI to eliminate pathogenic factors.Therapeutic Method of the present invention is easy, and the property of medicine is steady, and effect comprehensively.
Clinical test results such as embodiment 7 and embodiment 8 shows, Chinese medicine of the present invention can use separately Hepatoma therapy ascites, has preferably effect, and effective percentage reaches 87%; And execute in the process of controlling clinical, have no toxic and side effects, safe and reliable, can so that conditions of patients constantly takes a turn for the better, improve greatly patient's life quality.
Chinese medicine provided by the invention has overcome the defective of prior art, has outstanding substantive distinguishing features and progressive significantly with respect to prior art.
The specific embodiment
Embodiment 1
Herba Plantaginis 200g Herba Lobeliae Chinensis 100g Pericarpium Arecae 50g Herba Euphorbiae Helioscopiae 100g
Herba Leonuri 50g Semen Pharbitidis 20g Herba Solani Nigri 20g Ramulus Cinnamomi 20g
Semen Vaccariae 20g Radix Astragali 300g Herba Asari 20g
Get whole 11 flavor medical materials, extracting in water twice, the water that add 3600g the first time extracted 1 hour, added the water of 3600g for the second time, extracted 1 hour; Merge extractive liquid,, relative density is 1.20 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 50%, stir and spare, left standstill 12 hours, filter, relative density was 1.20 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
Embodiment 2
Herba Plantaginis 800g Herba Lobeliae Chinensis 500g Pericarpium Arecae 400g Herba Euphorbiae Helioscopiae 500g
Herba Leonuri 400g Semen Pharbitidis 300g Herba Solani Nigri 300g Ramulus Cinnamomi 300g
Semen Vaccariae 300g Radix Astragali 900g Herba Asari 300g
Get whole 11 flavor medical materials, extracting in water twice, the water that add 50000g the first time extracted 3 hours, added the water of 50000g for the second time, extracted 2 hours; Merge extractive liquid,, relative density is 1.25 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 60%, stir and spare, left standstill 24 hours, filter, relative density was 1.25 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
With active component and an amount of antioxidant, propellant mix homogeneously, namely get aerosol of the present invention.
Embodiment 3
Herba Plantaginis 400g Herba Lobeliae Chinensis 200g Pericarpium Arecae 100g Herba Euphorbiae Helioscopiae 200g
Herba Leonuri 100g Semen Pharbitidis 50g Herba Solani Nigri 50g Ramulus Cinnamomi 50g
Semen Vaccariae 50g Radix Astragali 400g Herba Asari 50g.
Get whole 11 flavor medical materials, be ground into fine powder, cross 80 mesh sieves, mix homogeneously namely gets powder agent of the present invention.
Embodiment 4
Herba Plantaginis 500g Herba Lobeliae Chinensis 300g Pericarpium Arecae 200g Herba Euphorbiae Helioscopiae 300g
Herba Leonuri 200g Semen Pharbitidis 100g Herba Solani Nigri 100g Ramulus Cinnamomi 100g
Semen Vaccariae 100g Radix Astragali 600g Herba Asari 100g.
Get whole 11 flavor medical materials, extracting in water twice, the water that add 20800g the first time extracted 2 hours, added the water of 15600g for the second time, extracted 1.5 hours; Merge extractive liquid,, relative density is 1.23 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 55%, stir and spare, left standstill 18 hours, filter, relative density was 1.23 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
Active component is cooperated with an amount of water-soluble base, stir, namely get ointment of the present invention.
Embodiment 5
Herba Plantaginis 400g Herba Lobeliae Chinensis 400g Pericarpium Arecae 300g Herba Euphorbiae Helioscopiae 400g
Herba Leonuri 300g Semen Pharbitidis 200g Herba Solani Nigri 200g Ramulus Cinnamomi 200g
Semen Vaccariae 200g Radix Astragali 400g Herba Asari 200g
Get whole 11 flavor medical materials, extracting in water twice, the water that add 16000g the first time extracted 2.5 hours, added the water of 19200g for the second time, extracted 1.8 hours; Merge extractive liquid,, relative density is 1.24 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 53%, stir and spare, left standstill 14 hours, filter, relative density was 1.22 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
Active component adds the adjuvants such as an amount of adhesive, wetting agent, filler, stirs, and coats on the back lining materials, namely gets gel rubber plaster unguentum of the present invention.
Embodiment 6
Herba Plantaginis 200g Herba Lobeliae Chinensis 300g Pericarpium Arecae 200g Herba Euphorbiae Helioscopiae 100g
Herba Leonuri 300g Semen Pharbitidis 230g Herba Solani Nigri 230g Ramulus Cinnamomi 230g
Semen Vaccariae 230g Radix Astragali 40g Herba Asari 60g
Get whole 11 flavor medical materials, the volume by volume concentration that adds 3180g is 60% alcohol dipping 24 hours, is that 53% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.3% with volume by volume concentration then, collect the percolate of 16960g, stir, filter, namely get tincture of the present invention.
Embodiment 7
The clinical trial situation of Chinese medicine of the present invention:
Case is selected: random Hepatoma therapy ascites 30 examples;
Therapeutic Method: take the Chinese medicine of the embodiment of the invention 4, once a day, the medicine coating SHENQUE acupoint with being equivalent to crude drug amount 40g sticked about 3 hours at every turn.
Table 1 treatment clinical efficacy data
| ? | The example number | Clinical produce effects | Clinical effective | Invalid | Total effective rate |
| Embodiment 4 medicines | 30 | 17 | 9 | 4 | 87% |
Embodiment 8
1, Bian, the woman, 77 years old, diagnosing liver cancer 3 years, disease is seen the epigastrium distending pain, is persistence, sign of ascites is positive, poor appetite, dimly red tongue, white and thin fur, stringy pulse.Execute through medicine of the present invention and to control, conscious urine is increased abdominal part distension pain relief after the week.
2, Gong, the man, 51 years old, be diagnosed as primary hepatocarcinoma, disease is seen abdominal distention, right flank section pain, the persistence distending pain, without fever with aversion to cold, poor appetite, soft tired power, oliguria.Execute through medicine of the present invention and to control, abdominal distention alleviates, and urine is increased, and appetite increases.
3, Zhao, the woman 61 years old, is diagnosed as primary hepatocarcinoma.Disease sees that the epigastrium distending pain is uncomfortable, poor appetite, the appearance xanthochromia, sleep poor night, yellow urine is few, two lower limbs edema, give Drug therapy of the present invention after, abdominal distention alleviates, urine is increased.
Claims (7)
1. the Chinese medicine of a Hepatoma therapy ascites is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Herba Plantaginis 20～80 Herba Lobeliae Chinensis 10～50 Pericarpium Arecae 5～40 Herba Euphorbiae Helioscopiae 10～50
Herba Leonuri 5～40 Semen Pharbitidiss 2～30 Herba Solani Nigris 2～30 Ramulus Cinnamomi 2～30
Semen Vaccariae 2～30 Radixs Astragali 30～90 Herba Asaris 2～30.
2. the Chinese medicine of Hepatoma therapy ascites as claimed in claim 1 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Herba Plantaginis 40～70 Herba Lobeliae Chinensis 20～40 Pericarpium Arecae 10～30 Herba Euphorbiae Helioscopiae 20～40
Herba Leonuri 10～30 Semen Pharbitidiss 5～20 Herba Solani Nigris 5～20 Ramulus Cinnamomi 5～20
Semen Vaccariae 5～20 Radixs Astragali 40～80 Herba Asaris 5～20.
3. the Chinese medicine of Hepatoma therapy ascites as claimed in claim 2 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Herba Plantaginis 50 Herba Lobeliae Chinensis 30 Pericarpium Arecae 20 Herba Euphorbiae Helioscopiae 30
Herba Leonuri 20 Semen Pharbitidiss 10 Herba Solani Nigris 10 Ramulus Cinnamomi 10
Semen Vaccariae 10 Radixs Astragali 60 Herba Asaris 10.
4. the Chinese medicine of Hepatoma therapy ascites as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get whole 11 flavor medical materials, extracting in water twice adds the water that is equivalent to 4～10 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 4～10 times of medical material gross weights, extracts 1～2 hour; Merge extractive liquid,, relative density is 1.20～1.25 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 50%～60%, stir even, left standstill 12～24 hours, filter, relative density was 1.20～1.25 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
5. the Chinese medicine of Hepatoma therapy ascites as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get whole 11 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 6～8 times of medical material gross weights, extracts 1.5 hours; Merge extractive liquid,, relative density is 1.23 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 55%, stir and spare, left standstill 12～24 hours, filter, relative density was 1.23 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
6. the Chinese medicine for the treatment of Hepatoma therapy ascites as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get whole 11 flavor medical materials, added the volume by volume concentration be equivalent to 1～2 times of this 11 flavor medical material gross weight and be 40%～60% alcohol dipping 12～48 hours, then be that 40%～60% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.2%～0.6% with volume by volume concentration, collection is equivalent to the percolate that this 11 flavor medical material gross weight 5-10 doubly measures, and obtains active component.
7. the Chinese medicine preparation of a Hepatoma therapy ascites comprises the Chinese medicine of each Hepatoma therapy ascites in the claim 1～6 and pharmaceutically acceptable carrier.
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| CN108355067A (en) * | 2018-04-18 | 2018-08-03 | 陈茂华 | The Chinese medicine for the treatment of cancer ascites |
| CN111588827A (en) * | 2020-05-27 | 2020-08-28 | 袁希福 | Externally-applied diuresis promoting ointment for treating cancerous chest and ascites and preparation method thereof |
| CN114869961A (en) * | 2022-04-29 | 2022-08-09 | 贵州中医药大学 | Medicine for treating cancerous ascites and preparation method thereof |
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Cited By (3)
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|---|---|---|---|---|
| CN108355067A (en) * | 2018-04-18 | 2018-08-03 | 陈茂华 | The Chinese medicine for the treatment of cancer ascites |
| CN111588827A (en) * | 2020-05-27 | 2020-08-28 | 袁希福 | Externally-applied diuresis promoting ointment for treating cancerous chest and ascites and preparation method thereof |
| CN114869961A (en) * | 2022-04-29 | 2022-08-09 | 贵州中医药大学 | Medicine for treating cancerous ascites and preparation method thereof |
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| CN103055078B (en) | 2014-09-17 |
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