CN101856475B - Chinese medicinal composition for treating gynecological inflammation and preparation method thereof - Google Patents
Chinese medicinal composition for treating gynecological inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of Chinese medicaments, and discloses a Chinese medicinal composition for treating gynecological inflammation, which comprises the following raw material medicinal materials in part by weight: 15 to 25 parts of paris polyphylla var. chinensis, 15 to 25 parts of java brucea fruit, 25 to 35 parts of mountain dragon, 25 to 35 parts of swamp mahogany leaf, 20 to 30 parts of common cnidium fruit, 20 to 30 parts of stemona parviflora, 25 to 35 parts of climbing groundsel herb, 30 to 40 parts of glochidion eriocarpum champ and 25 to 35 parts of mentha haplocalyx. The invention also provides a preparation method and cleansing solution of the Chinese medicinal composition. The Chinese medicinal composition of the invention has the effects of dampness elimination, antibiosis, disinsection, itching relieving and peculiar smell elimination, has the good effect of treating the gynecological inflammation, and has the extensive application prospect.
Description
Technical field
The present invention relates to tcm field, be specifically related to a kind of Chinese medicine composition for the treatment of gynecological inflammation and preparation method thereof.
Background technology
Gynecological inflammation mainly is meant women genitals's inflammation, comprise vaginitis, cervicitis, pelvic inflammatory disease that a variety of causes causes, pruritus vulvae often occurs, scorching hotly swell and ache, vaginal congest, leucorrhea bean dregs sample, leucorrhea amount are many, dyspareunia, frequent micturition, urgent micturition, dysurea, lower abdomen are weighed down symptoms such as bloated, influence women's quality of life when serious, the inflammation repeated infection also can be encroached on other organs of female reproduction, even may threaten to life.
Show according to the relevant statistics of World Health Organization (WHO), women's gynecological inflammation prevalence height, with regard to its degree, the married woman or the women of child-bearing age's the state of an illness is even more serious, the cause of disease is more complicated, the course of disease is more very long, and the women more than 5% is wherein arranged, due to illness feelings serious and influenced normal study, work or life.
The Chinese traditional treatment gynecological inflammation is from integral body, or eliminating damp-heat, or invigorating the spleen for eliminating dampness, or liver and kidney tonifying, or soothing liver and strengthening spleen, is equipped with killing parasites for relieving itching; In treatment by oral administration of medicines, in conjunction with external treatment, Chinese medicine, clinical efficacy is good, and side effect is little.
Theory of Chinese medical science thinks, the main damp of gynecological inflammation has inside and outside branch again for suffering from, and main pathogenesis can reduce the imbalance of liver spleen renal function, and damp injures to appoint is with two arteries and veins, makes that conception vessel loses admittedly, dai channel is failed to keep an appointment.Can divide again specifically that dampness-heat of the liver, deficiency of YIN folder is wet, turbid damp pents up.Gynecological inflammation such as vaginitis and pudendal pruritus belong to the traditional Chinese medical science " pudendal pruritus ", " leukorrheal diseases " category.Golden Mirror of Medicine is thought, married woman's pudendal pruritus, and how because of parasite caused by accumulation of damp-heat in the body, insect poison is had an itch." Complete Effective Prescriptions for Women " says: Mr. and Mrs people pudendal pruritus person is that worm-eaten is done.Three worms are between the intestines and stomach that because of deficiency of five ZANG-organs, the action of three worms is in the ulceration at external genitals.Its worm makes heat, and is little then for itching, heavy then be bitterly also.Leukorrhagia too much is meant woman's leukorrhagia amount showed increased, and color, matter, abnormal smells from the patient are unusual, or with part and General Symptoms person." women section brief points " proposes leukorrhagia too much is to be lost due to empty, yang-energy sink by taste, advocates spleen invigorating yang invigorating leukorrhagia stopping.
The Chinese medicine for the treatment of gynecological inflammation in the market is many based on oral drugs, but there is the shortcoming that drug level is low, can not directly act on the affected part in the oral drugs medicine, and curative effect is not good enough.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of treatment gynecological inflammation of determined curative effect.
In order to realize the foregoing invention purpose, the present invention by the following technical solutions:
A kind of Chinese medicine composition for the treatment of gynecological inflammation, its raw material comprises in weight portion:
Rhizoma Paridis 15-25 part Fructus Bruceae 15-25 part Caulis Arcangelisiae 25-35 part
Folium Eucalypti Robustae 25-35 part Fructus Cnidii 20-30 part is carefully spent Radix Stemonae 20-30 part
Herba Senecionis Scandentis 25-35 part comospore Fructus glochidionis puberi(Herba Glochidii Puberi) 30-40 part Herba Menthae 25-35 part.
Rhizoma Paridis, latin name Paris polyphylla var.chinensis is the Liliaceae herbaceos perennial.Yin Qiye mostly is 7 wheels and is born in the stem item, singly is born on the verticillate blade and gains the name and spend.Rhizoma Paridis is used as medicine with rhizome, and heat-clearing and toxic substances removing, reducing swelling and alleviating pain effect are arranged.
Fructus Bruceae, latin name Fructus Bruceae, the fruit of Java Brucea Fruit quassia Fructus Bruceae Brucea javanica (L.) Merr., cold in nature, bitter in the mouth; Slightly poisonous.Heat-clearing and toxic substances removing, preventing the attack (or recurrence) of malaria, dysentery relieving, corrosion wart.Be used for dysentery, malaria.
Caulis Arcangelisiae, latin name Arcangelisia loureiri (Pierre) Diels, another name Caulis Fibraureae, Rhizoma Coptidis rattan for Menispermaceae Caulis Arcangelisiae platymiscium, are used as medicine with rattan and root.Bitter in the mouth, cold in nature.Clearing away heat-damp and promoting diuresis, the detoxifcation pain relieving.Be used to prevent influenza, leptospirosis, control acute gastroenteritis, bacillary dysentery, tonsillitis, bronchitis, malaria etc.
Folium Eucalypti Robustae is the leaf of myrtle Folium Eucalypti Robustae.Folium Eucalypti Robustae has another name called: the young tree of mosquito.Little suffering of distinguishing the flavor of is puckery, and property is flat.Heat-clearing and toxic substances removing.Cure cold, acute enteritis, dysentery, pyelonephritis, erysipelas, carbuncle is scalded traumatic infection, ulcer of the lower limb, suppurative keratitis, atrophic rhinitis.
Fructus Cnidii, warm in nature for the dry mature fruit of samphire cnidium monnieri Cnidium monnieri (L.) Cuss., acrid in the mouth, hardship.Warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
The thin flower Radix Stemonae, Stemona parviflora is the plant of Stemonaceae Stemona, is the endemic plant of China.Be distributed in the ground such as Hainan of China's Mainland.
Herba Senecionis Scandentis, Senecio scandens Buch.-Ham. are dicotyledon Compositae Senecio plant.With all herbal medicine.Hardship, sweet, cold, suffering, cold.Nontoxic.Heat-clearing and toxic substances removing, parasite killing, make eye bright.Modern pharmacological research shows that it has antibacterial action, anti-spirillum effect and suppresses the trichomonas vaginitis effect.
The comospore Fructus glochidionis puberi(Herba Glochidii Puberi), another name Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), lacquer uncle, hair lacquer, setation lacquer, the tree root of itching, MAOQI public affairs are Euphorbiaceae Glochidion plant comospore Fructus glochidionis puberi(Herba Glochidii Puberi) Glochidion eriocarpum Champ. Herb or root, leaf hyoscine, property hardship, puckery is distinguished the flavor of and is put down.Separate dermatitis rhus, the effect of astringing to arrest diarrhea, removing dampness to relieve itching.That modern study, gallic acid that this plant is contained and derivant thereof all have is antibiotic, antitumor, antioxidation and anti-HBV effect isoreactivity.
Herba Menthae is the dry aerial parts of labiate Herba Menthae Mentha haplocalyx Briq..Acrid in the mouth, cool in nature.Return lung, Liver Channel.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.
Described gynecological inflammation comprises vaginitis, cervicitis, pelvic inflammatory disease.
As preferably, its raw material comprises in weight portion:
Rhizoma Paridis 18-22 part Fructus Bruceae 18-22 part Caulis Arcangelisiae 28-32 part
Folium Eucalypti Robustae 28-32 part Fructus Cnidii 25-28 part is carefully spent Radix Stemonae 22-38 part
Herba Senecionis Scandentis 28-32 part comospore Fructus glochidionis puberi(Herba Glochidii Puberi) 32-45 part Herba Menthae 28-32 part.
More preferably, its raw material comprises in weight portion:
30 parts of 20 portions of Caulis Arcangelisiaes of 20 parts of Fructus Bruceaes of Rhizoma Paridis
25 parts of 25 parts thin flower Radixs Stemonae of 30 parts of Fructus Cnidiis of Folium Eucalypti Robustae
30 parts of 35 portions of Herba Menthaes of 30 parts of comospore Fructus glochidionis puberi(Herba Glochidii Puberi)s of Herba Senecionis Scandentis.
The present invention also provides the clinical dosage form of described Chinese medicine composition.Those skilled in the art can add described Chinese medicine composition various conventional adjuvant required when preparing different dosage form, as disintegrating agent, lubricant, binding agent etc., with conventional method of Chinese medicinal, directly or indirectly add acceptable accessories through conventional processing and make gynecological's common dosage forms such as suppository, gel, tablet, membrane, lotion, capsule, Emulsion, paste etc.
In an embodiment, the present invention also specifically provides washing liquid of described Chinese medicine composition and preparation method thereof, because directly in the face of focus, easy to use, this dosage form treatment gynecological inflammation is subjected to the favor of clinical patients.
Another object of the present invention is to provide the preparation method of described Chinese medicine composition, this preparation method comprises following steps:
Step 1: the Fructus Cnidii and the 20-30 part of getting the 20-30 weight portion carefully spend the Radix Stemonae to pulverize, alcohol reflux, and extracting solution filters, and gets filtrate recycling ethanol to there not being the alcohol flavor, and medicinal residues are standby;
Step 2: get 15-25 weight portion Rhizoma Paridis, 15-25 weight portion Fructus Bruceae, 25-35 weight portion Caulis Arcangelisiae, 25-35 weight portion Folium Eucalypti Robustae, 25-35 weight portion Herba Senecionis Scandentis, 30-40 weight portion comospore Fructus glochidionis puberi(Herba Glochidii Puberi), 25-35 weight portion Herba Menthae and step 1 gained medicinal residues, extracting in water 3 times, filter behind the merge extractive liquid,, get filtrate for later use;
Step 3: get step 1 and step 2 gained filtrate, merge, be concentrated into the clear paste of relative density 1.30, precipitate with ethanol is got supernatant and is reclaimed ethanol to there not being the alcohol flavor.
As preferably, step 1 is specially: the Fructus Cnidii and the 20-30 part of getting the 20-30 weight portion carefully spend the Radix Stemonae to pulverize, and spend the night with the soak with ethanol of 70-90%, heating and refluxing extraction 2 times, each 1.5 hours, merge extractive liquid,, filter filtrate recycling ethanol to there not being the alcohol flavor, medicinal residues are standby.
As preferably, described step 2 is specially gets 15-25 weight portion Rhizoma Paridis, 15-25 weight portion Fructus Bruceae, 25-35 weight portion Caulis Arcangelisiae, 25-35 weight portion Folium Eucalypti Robustae, 25-35 weight portion Herba Senecionis Scandentis, 30-40 weight portion comospore Fructus glochidionis puberi(Herba Glochidii Puberi), 25-35 weight portion Herba Menthae and step 1 gained medicinal residues, extract merge extractive liquid, respectively 3 times with 6 times of water gagings, filter filtrate for later use.
As preferably, described step 3 is specially gets step 1 and step 2 gained filtrate merges, and is evaporated to the clear paste of relative density 1.30, adds ethanol and makes and contain the alcohol amount and reach about 75%, places 12 hours, gets supernatant, reclaims ethanol and does not distinguish the flavor of to there being alcohol.
Another object of the present invention provides the Chinese medicine composition by method for preparing.
The present invention also provides the washing liquid of described Chinese medicine composition, and the Chinese medicine composition thin up 4-6 that is about to method for preparing doubly adjusts pH and be 5-7 promptly.
The present invention in 51 routine vaginitiss and cervicitis patient, after 5 days, cures 40 examples with medicine liquid washing through clinical observation on the therapeutic effect, and cure rate accounts for 78.4%, 10 examples that take a turn for the better, and obvious effective rate accounts for 19.6%, and total effective rate is 98.0%, invalid 1 example, inefficiency accounts for 2%.
The invention provides a kind of Chinese medicine composition of determined curative effect, modern pharmacological research and clinical trial show: described Chinese medicine composition has damp eliminating, antibiotic, parasite killing, antipruritic, the effect of eliminating abnormal flavour, to mucocutaneous nonirritant, no anaphylaxis, have no side effect, not pollution clothes, have safety and comfort highly.Be mainly used in the treatment of gynecological inflammations such as vaginitis, cervicitis clinically.
The specific embodiment
The invention discloses a kind of Chinese medicine composition for the treatment of gynecological inflammation, washing liquid and preparation method thereof, those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as being included in the present invention.Product of the present invention and application are described by preferred embodiment, the related personnel obviously can change or suitably change and combination methods and applications as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use the technology of the present invention.
Below in conjunction with embodiment, further set forth the present invention:
Embodiment 1
A kind of vaginal lotion for the treatment of gynecological inflammation, its prescription by following weight than forming:
Rhizoma Paridis 20g Fructus Bruceae 20g Caulis Arcangelisiae 30g
Folium Eucalypti Robustae 30g Fructus Cnidii 25g carefully spends Radix Stemonae 25g
Herba Senecionis Scandentis 30g comospore Fructus glochidionis puberi(Herba Glochidii Puberi) 35g Herba Menthae 30g.
The preparation method of this Chinese medicine washing liquid is as follows:
Step 1, get the Fructus Cnidii of described weight and carefully spend the Radix Stemonae, wear into coarse powder, spend the night with the soak with ethanol of 70%-90%, heating and refluxing extraction 2 times, each 1.5 hours, merging filtrate filtered, and reclaimed ethanol and did not distinguish the flavor of to there being alcohol, and medicinal residues are standby.
The medicinal residues of step 2, the Rhizoma Paridis of getting described weight, Fructus Bruceae, Caulis Arcangelisiae, Folium Eucalypti Robustae, Herba Senecionis Scandentis, comospore Fructus glochidionis puberi(Herba Glochidii Puberi), Herba Menthae and step 1, with 6-8 times of water gaging, extract 3 times (2 hours, 1.5 hours, 1 hour) merging filtrate respectively, filter, standby.
Step 3, get the extracting solution of step 1 and step 2, merge, be evaporated to the clear paste of relative density 1.30, add ethanol, make to contain the alcohol amount and reach about 70%, be positioned over cool place 12 hours, get supernatant, reclaim ethanol to there not being the alcohol flavor, standby.
Step 4, get step 3 extracting solution, be diluted to 5 times of amounts of crude drug with water for injection, stir, adjustment pH is 5-7, is distributed into bottle, promptly.
Embodiment 2
A kind of vaginal lotion for the treatment of gynecological inflammation, its prescription by following weight than forming:
Rhizoma Paridis 15g Fructus Bruceae 15g Caulis Arcangelisiae 25g Folium Eucalypti Robustae 25g Fructus Cnidii 20g carefully spends Radix Stemonae 20g Herba Senecionis Scandentis 25g comospore Fructus glochidionis puberi(Herba Glochidii Puberi) 30g Herba Menthae 25g.
The preparation method of this Chinese medicine washing liquid is as follows:
Step 1, get the Fructus Cnidii of described weight and carefully spend the Radix Stemonae, coarse powder spends the night with 70% soak with ethanol, heating and refluxing extraction 2 times, and each 1.5 hours, merging filtrate filtered, and reclaimed ethanol and did not distinguish the flavor of to there being alcohol, and medicinal residues are standby.
The medicinal residues of step 2, the Rhizoma Paridis of getting described weight, Fructus Bruceae, Caulis Arcangelisiae, Folium Eucalypti Robustae, Herba Senecionis Scandentis, comospore Fructus glochidionis puberi(Herba Glochidii Puberi), Herba Menthae and step 1, with 6 times of water gagings, extract 3 times (2 hours, 1.5 hours, 1 hour) merging filtrate respectively, filter, standby.
Step 3, get the extracting solution of step 1 and step 2, merge, be evaporated to the clear paste of relative density 1.30, add ethanol, make to contain the alcohol amount and reach about 75%, be positioned over cool place 12 hours, get supernatant, reclaim ethanol to there not being the alcohol flavor, standby.
Step 4, get step 3 extracting solution, be diluted to 5 times of amounts of crude drug with water for injection, stir, adjusting pH is 5, is distributed into bottle, promptly.
Embodiment 3:
A kind of vaginal lotion for the treatment of gynecological inflammation, its prescription by following weight than forming:
Rhizoma Paridis 25g Fructus Bruceae 25g Caulis Arcangelisiae 35g Folium Eucalypti Robustae 35g Fructus Cnidii 30g carefully spends Radix Stemonae 30g Herba Senecionis Scandentis 35g comospore Fructus glochidionis puberi(Herba Glochidii Puberi) 40g Herba Menthae 35g.
The preparation method of this Chinese medicine washing liquid is as follows:
Step 1, get the Fructus Cnidii of described weight and carefully spend the Radix Stemonae, coarse powder spends the night with 90% soak with ethanol, heating and refluxing extraction 2 times, and each 1.5 hours, merging filtrate filtered, and reclaimed ethanol and did not distinguish the flavor of to there being alcohol, and medicinal residues are standby.
The medicinal residues of step 2, the Rhizoma Paridis of getting described weight, Fructus Bruceae, Caulis Arcangelisiae, Folium Eucalypti Robustae, Herba Senecionis Scandentis, comospore Fructus glochidionis puberi(Herba Glochidii Puberi), Herba Menthae and step 1, with 8 times of water gagings, extract 3 times (2 hours, 1.5 hours, 1 hour) merging filtrate respectively, filter, standby.
Step 3, get the extracting solution of step 1 and step 2, merge, be evaporated to the clear paste of relative density 1.30, add ethanol, make to contain the alcohol amount and reach about 65%, be positioned over cool place 12 hours, get supernatant, reclaim ethanol to there not being the alcohol flavor, standby.
Step 4, get step 3 extracting solution, be diluted to 5 times of amounts of crude drug with water for injection, stir, adjusting pH is 7, is distributed into bottle, promptly.
Embodiment 4: the suppository for preparing Chinese medicine composition of the present invention
Prescription:
Rhizoma Paridis 18-22g Fructus Bruceae 18-22g Caulis Arcangelisiae 28-32g
Folium Eucalypti Robustae 28-32g Fructus Cnidii 25-28g carefully spends Radix Stemonae 22-38g
Herba Senecionis Scandentis 28-32g comospore Fructus glochidionis puberi(Herba Glochidii Puberi) 32-45g Herba Menthae 28-32g.
Prepare extracting solution by step 1-3 in the described method of embodiment 1-3, the conventional adjuvant that adds suppository after drying under reduced pressure or the spray drying is prepared into suppository according to a conventional method.
Embodiment 5: the ointment for preparing Chinese medicine composition of the present invention
Prescription:
Rhizoma Paridis 15-25g Fructus Bruceae 15-25g Caulis Arcangelisiae 25-35g
Folium Eucalypti Robustae 25-35g Fructus Cnidii 20-30g carefully spends Radix Stemonae 20-30g
Herba Senecionis Scandentis 25-35g comospore Fructus glochidionis puberi(Herba Glochidii Puberi) 30-40g Herba Menthae 25-35g.
Prepare extracting solution by step 1-3 in the described method of embodiment 1-3, the conventional adjuvant that adds ointment after drying under reduced pressure or the spray drying is prepared into ointment according to a conventional method.
Embodiment 6: make colpitic animal model
After the female adult white mice spay, injection estrogen makes animal be in lasting false rutting period.The vaginal wall of laboratory animal increases owing to the epithelium glycogen, mucous hyperemia, and hypersecretion, pudendum is moistening, and the Glucose Liquid washing vagina with 10% changes vagina pH value and environment, can improve the adhesive capacity of Candida albicans bacterial strain and vaginal wall cell.
Experimental bacteria: the reference culture at clinical genital candidiasis patient institute's strain separated or medical mycology preservation center.Recover virulence through white mice earlier before the test.
Reagent: 10% urethane aqueous solution of ester, absolute ether (white mice anesthesia is used), diethylstilbestrol injection 2mg/mL.
Anesthesia: animal is weighed before the test, invests the high lumbar injection 10% urethane ester solution of equal rank by 10mL/kg, and animal is in narcotism after several minutes.White mice can be used etherization.
Spay: after the anesthesia, the animal outside of belly makes progress, and extremity fully launch, and centre is done longitudinal incision in 1cm place, pubis top, separate the abdominal wall muscle layer, open the abdominal cavity, find ovary to both sides, use the stitching thread ligation along the bottom, uterus, excision is closed the abdominal cavity, layer-by-layer suture after the hemostasis.
Injection estrogen: after the animal recovery, intramuscular injection diethylstilbestrol 0.5mL, white mice 0.1mL.In injection 1 week of back, the animal pudendum is moistening, and vaginal secretions increases, for being in false rutting period.Viewing duration is with 10% G/W washing vagina.
Inoculation: after about 1 week, with the experimental strain of cultivating 48 hours, be made into the bacterium liquid of 1.0 * 10 6 power CFU/mL with isotonic saline solution, every animal is with capillary burette intravaginal inoculation 0.1mL.The pudendum redness appears in animal after about 3 days, and secretions obviously increases, and severe patient can be seen white coagulum shape secretions and discharge from vagina.
Embodiment 7. Chinese medicine compositions of the present invention are to the irritant test of vaginal mucosa
(1) medicine: the Chinese medicine composition of making by embodiment 1-5.
8 of the animal models of (2) animal: embodiment 6 preparations, body weight 2.0 ± 0.2kg.
(3) method: animal is divided into two groups at random, 4 every group.Chinese medicine composition of the present invention is injected administration treated animal vagina, and matched group gives the distilled water with volume, once a day, successive administration 7 days is observed part and general reaction, 24 hours execution animals after the last administration, take out vagina tissue, carry out outward appearance and histopathologic examination.
(4) result: two treated animals there is no unusual systemic reaction after the administration, and external genital does not have phenomenons such as hyperemia, redness, vagina tissue and mucosa pinkiness or lavender, do not see hyperemia is arranged, irritant reaction such as redness.The tissue slice mirror is observed down, does not see that Chinese medicine composition group of the present invention and matched group have pathological change, and test shows that Chinese medicine composition of the present invention does not have bad stimulation to vaginal mucosa.
The observation of curative effect of embodiment 8 Chinese medicine compositions of the present invention
Observe the curative effect of using traditional Chinese medicine composition for treating vaginitis of the present invention, cervicitis.
Method: 102 routine vaginitis patients are divided into experimental group and matched group at random, experimental group 51 examples, matched group 51 examples, the external wash liquid demibain of the Chinese medicine composition of Application Example 1-5 preparation or suppository or ointment, the scorching clean demibain of commercially available woman are treated respectively.
Diagnostic criteria: with reference to the clinical diagnosis standard, and light with the symptom calibration, in, severe.
Therapeutic Method: experimental group is sent into vagina deep indwelling taking-up after 6-8 hour with Chinese medicine composition washing liquid morning and evening washing vagina of the present invention or with suppository, ointment.Stop other western medicines in treatment during the treatment.
The present invention clinically, obtain curative effect preferably, in 51 routine vaginitiss and cervicitis patient, used medicine liquid washing after 5 days, cure 40 examples, cure rate accounts for 78.4%, 10 examples that take a turn for the better, and obvious effective rate accounts for 19.6%, total effective rate is 98.0%, invalid 1 example, inefficiency accounts for 2%, no difference of science of statistics between washing liquid and suppository, ointment group.The matched group cure rate is that 60.0%, two group of cure rate relatively has significant difference (P＜0.05).
Conclusion: traditional Chinese medicine composition for treating vaginitis of the present invention and cervicitis, at anti-inflammation simultaneously, regulate the intravaginal environment, improve the vaginal mucosa resistance, evident in efficacy.In addition, as seen, Chinese medicine composition itching-relieving action of the present invention is especially obvious in the clinical observation, and antipruritic effect was fast after the patient reacted medication, and it is comfortable that the part is felt.Chinese medicine composition of the present invention is not found toxic and side effects in using, and is the good medicine of prevention and treatment gynecological inflammation, is worthy of popularization.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (11)
1. Chinese medicine composition for the treatment of gynecological inflammation, its crude drug is counted with weight portion:
Rhizoma Paridis 15-25 part Fructus Bruceae 15-25 part Caulis Arcangelisiae 25-35 part
Folium Eucalypti Robustae 25-35 part Fructus Cnidii 20-30 part is carefully spent Radix Stemonae 20-30 part
Herba Senecionis Scandentis 25-35 part comospore Fructus glochidionis puberi(Herba Glochidii Puberi) 30-40 part Herba Menthae 25-35 part.
2. Chinese medicine composition according to claim 1 is characterized in that described gynecological inflammation comprises vaginitis, cervicitis, pelvic inflammatory disease.
3. Chinese medicine composition according to claim 1 is characterized in that, its crude drug is counted with weight portion:
30 parts of 20 portions of Caulis Arcangelisiaes of 20 parts of Fructus Bruceaes of Rhizoma Paridis
25 parts of 25 parts thin flower Radixs Stemonae of 30 parts of Fructus Cnidiis of Folium Eucalypti Robustae
30 parts of 35 portions of Herba Menthaes of 30 parts of comospore Fructus glochidionis puberi(Herba Glochidii Puberi)s of Herba Senecionis Scandentis.
4. the clinical dosage form of each described Chinese medicine composition of claim 1-3.
5. clinical dosage form according to claim 4 is characterized in that, it is a washing liquid.
6. preparation method for the treatment of the Chinese medicine composition of gynecological inflammation comprises following steps:
Step 1: the Fructus Cnidii and the 20-30 part of getting the 20-30 weight portion carefully spend the Radix Stemonae to pulverize, alcohol reflux, and extracting solution filters, and gets filtrate recycling ethanol to there not being the alcohol flavor, and medicinal residues are standby;
Step 2: get 15-25 weight portion Rhizoma Paridis, 15-25 weight portion Fructus Bruceae, 25-35 weight portion Caulis Arcangelisiae, 25-35 weight portion Folium Eucalypti Robustae, 25-35 weight portion Herba Senecionis Scandentis, 30-40 weight portion comospore Fructus glochidionis puberi(Herba Glochidii Puberi), 25-35 weight portion Herba Menthae and step 1 gained medicinal residues, extracting in water 3 times, filter behind the merge extractive liquid,, get filtrate for later use;
Step 3: get step 1 and step 2 gained filtrate, merge, be concentrated into the clear paste of relative density 1.30, precipitate with ethanol is got supernatant and is reclaimed ethanol to there not being the alcohol flavor.
7. preparation method according to claim 6, it is characterized in that, described step 1 is specially: the Fructus Cnidii and the 20-30 part of getting the 20-30 weight portion carefully spend the Radix Stemonae to pulverize, soak with ethanol with 70-90% is spent the night, heating and refluxing extraction 2 times, each 1.5 hours, merge extractive liquid,, filter filtrate recycling ethanol to there not being the alcohol flavor, medicinal residues are standby.
8. preparation method according to claim 6, it is characterized in that, described step 2 is specially gets 15-25 weight portion Rhizoma Paridis, 15-25 weight portion Fructus Bruceae, 25-35 weight portion Caulis Arcangelisiae, 25-35 weight portion Folium Eucalypti Robustae, 25-35 weight portion Herba Senecionis Scandentis, 30-40 weight portion comospore Fructus glochidionis puberi(Herba Glochidii Puberi), 25-35 weight portion Herba Menthae and step 1 gained medicinal residues, extract merge extractive liquid, respectively 3 times with 6 times of water gagings, filter filtrate for later use.
9. preparation method according to claim 6 is characterized in that, described step 3 is specially gets step 1 and the merging of step 2 gained filtrate, be evaporated to the clear paste of relative density 1.30, add ethanol and make and contain the alcohol amount and reach 75%, placed 12 hours, get supernatant, reclaim ethanol to there not being the alcohol flavor.
10. according to the Chinese medicine composition of the described preparation method of claim 6-9 preparation.
11. a washing liquid for the treatment of gynecological inflammation is characterized in that, with the described Chinese medicine composition thin up of claim 10 4-6 doubly, adjusts pH and be 5-7 promptly.
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| CN102600307B (en) * | 2012-03-16 | 2014-07-23 | 蒋勇 | Topical Chinese medicinal composition for treating Weil's disease |
| CN103520593B (en) * | 2013-10-03 | 2015-06-24 | 青岛市市立医院 | Chinese herba preparation for treating trichomonas vaginitis and preparation method thereof |
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