CN114949108B - Traditional Chinese medicine composition for treating prostatitis and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating prostatitis and preparation method and application thereof Download PDFInfo
- Publication number
- CN114949108B CN114949108B CN202210695104.3A CN202210695104A CN114949108B CN 114949108 B CN114949108 B CN 114949108B CN 202210695104 A CN202210695104 A CN 202210695104A CN 114949108 B CN114949108 B CN 114949108B
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizoma
- chinese medicine
- traditional chinese
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for treating prostatitis, which comprises the following raw material medicines and is prepared by extraction: the solid preparation prepared from the cortex moutan, the rhizoma alismatis, the rhizoma anemarrhenae, the cortex phellodendri, the radix salviae miltiorrhizae, the herba lycopi, the radix paeoniae rubra, the peach kernel and the like by adopting the corresponding preparation method has good effects of nourishing yin, clearing heat, promoting blood circulation, removing blood stasis, tonifying kidney, treating stranguria, clearing heat, promoting qi circulation, removing food retention and treating prostatitis with the syndrome of fire-heat due to yin deficiency.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating prostatitis, a preparation method and application thereof.
Background
Prostatitis refers to acute and chronic inflammation caused by specific and nonspecific infection of the prostate, and thus causes systemic or local symptoms. Prostatitis can be classified into nonspecific bacterial prostatitis, idiopathic bacterial prostatitis (also called prostatosis), specific prostatitis (caused by gonococcus, tubercle bacillus, fungi, parasites, etc.), nonspecific granulomatous prostatitis, prostatitis caused by other pathogens (such as virus, mycoplasma, chlamydia, etc.), prostatic congestion, and prostatodynia. Clinically, the prostates are classified into acute prostatitis and chronic prostatitis, and the acute prostatitis is characterized by sudden fever, aversion to cold, frequent urination, urgent urination, painful urination, perineum and anus pain and the like, and belongs to the category of 'stranguria' or 'stranguria turbidity' in the traditional Chinese medicine. If the acute prostatitis has abscess, the acute prostatitis can be diagnosed as carbuncle and 'crotch' in traditional Chinese medicine, and for the chronic prostatitis, the acute prostatitis has the clinical characteristics of lumbosacral pain, lower abdomen, perineum and testis falling and swelling pain, frequent urination, painful urination or urethra burning sensation, abnormal secretion overflowed in urine, and the chronic prostatitis is characterized by belonging to the categories of 'stranguria turbidity', 'white turbidity', 'overstrain' and the like in traditional Chinese medicine. The middle-period excessive stasis and turbidity blocking type mainly shows that the perineum and the rear urethra are obviously stabbed, the pain is induced to the testis, the penis, the groin or the waist, the urine dribbling is incomplete, the phenomenon of the white urine dribbling is occasional or vanishes, the tongue is dark or has ecchymosis, and the pulse is wiry and astringent. Palpation of the prostate gland, hard texture, normal size or small size or knots and tenderness; the prostate liquid has leucocytes, red blood cells and obviously reduced lecithin corpuscles. The kidney deficiency and blood stasis type symptoms are mainly kidney deficiency and blood stasis type symptoms such as soreness of waist, lumbago, insomnia, seminal emission, premature ejaculation, sexual hypofunction, dribbling urine and white urine. A thick or dark tongue and a deep and weak pulse; the anus means that the prostate is checked for nodules, the central groove becomes shallow, no pressure pain exists, and the small body of the lecithin in the prostate liquid is obviously reduced. In the latter stage, if the symptoms are mainly urination frequency, urination burning heat, spermatorrhea, premature ejaculation, premature urination, dizziness, tinnitus, dry mouth, dry throat, dysphoria with feverish sensation in the chest, and prostatitis of yin deficiency and fire heat type, the disease can occur all the year round, and the disease is sporadic in winter and spring.
According to the analysis, the main cause of the yin deficiency fire heat type prostatitis is excessive sexual intercourse or strong tolerance, kidney essence loss, yin deficiency fire hyperactivity and fire movement, if only clearing heat and promoting diuresis are used, the curative effect is not ideal, so the symptoms and root causes must be treated. Therefore, a traditional Chinese medicine prescription capable of treating both principal and secondary aspect of disease and having obvious curative effect is needed to treat prostatitis.
Disclosure of Invention
The invention aims to: in order to solve the problems, the invention aims to provide a traditional Chinese medicine composition for treating prostatitis, and a preparation method and application thereof.
The technical scheme is as follows: the invention aims at realizing the following scheme:
the traditional Chinese medicine composition for treating prostatitis is prepared from the following raw materials in parts by weight through extraction: 20-26 parts of moutan bark, 10-16 parts of rhizoma alismatis, 12-18 parts of rhizoma anemarrhenae, 8-12 parts of cortex phellodendri, 8-16 parts of radix salviae miltiorrhizae, 10-16 parts of herba lycopi, 10-14 parts of radix paeoniae rubra, 6-10 parts of peach kernel, 10-20 parts of rhizoma acori graminei, 8-16 parts of semen cuscutae, 10-16 parts of radix rehmanniae, 12-18 parts of prepared rehmannia root, 8-14 parts of semen astragali complanati, 8-14 parts of rhizoma dioscoreae septemlobae, 10-16 parts of semen plantaginis, 10-16 parts of polygonum aviculare, 15-20 parts of fringed pink, 8-14 parts of szechwan chinaberry fruit, 12-18 parts of green tangerine peel, 10-16 parts of fennel and 8-12 parts of herba patriniae.
The traditional Chinese medicine composition for treating prostatitis comprises the following raw material medicines in parts by weight and is prepared by extraction: 23 parts of moutan bark, 14 parts of rhizoma alismatis, 14 parts of rhizoma anemarrhenae, 10 parts of cortex phellodendri, 12 parts of radix salviae miltiorrhizae, 13 parts of herba lycopi, 12 parts of radix paeoniae rubra, 8 parts of peach kernel, 15 parts of rhizoma acori graminei, 12 parts of semen cuscutae, 13 parts of radix rehmanniae, 15 parts of prepared rehmannia root, 12 parts of semen astragali complanati, 12 parts of rhizoma dioscoreae, 13 parts of semen plantaginis, 13 parts of polygonum aviculare, 18 parts of herba dianthi, 10 parts of fructus toosendan, 14 parts of green tangerine peel, 13 parts of fennel and 10 parts of herba patriniae.
The traditional Chinese medicine composition for treating prostatitis comprises the following raw material medicines in parts by weight and is prepared by extraction: 20 parts of moutan bark, 16 parts of rhizoma alismatis, 12 parts of rhizoma anemarrhenae, 12 parts of cortex phellodendri, 8 parts of radix salviae miltiorrhizae, 16 parts of herba lycopi, 10 parts of radix paeoniae rubra, 10 parts of peach kernel, 10 parts of rhizoma acori graminei, 16 parts of semen cuscutae, 10 parts of radix rehmanniae, 18 parts of prepared rehmannia root, 8 parts of semen astragali complanati, 14 parts of rhizoma dioscoreae, 10 parts of semen plantaginis, 16 parts of polygonum aviculare, 15 parts of herba dianthi, 14 parts of fructus toosendan, 12 parts of green tangerine orange peel, 16 parts of fennel and 8 parts of herba patriniae.
The traditional Chinese medicine composition for treating prostatitis comprises the following raw material medicines in parts by weight and is prepared by extraction: 26 parts of moutan bark, 10 parts of rhizoma alismatis, 18 parts of rhizoma anemarrhenae, 8 parts of cortex phellodendri, 16 parts of radix salviae miltiorrhizae, 10 parts of herba lycopi, 14 parts of radix paeoniae rubra, 6 parts of peach kernel, 20 parts of rhizoma acori graminei, 8 parts of semen cuscutae, 16 parts of radix rehmanniae, 12 parts of prepared rehmannia root, 14 parts of semen astragali complanati, 8 parts of rhizoma dioscoreae, 16 parts of semen plantaginis, 10 parts of polygonum aviculare, 20 parts of herba dianthus superbus, 8 parts of fructus toosendan, 18 parts of green tangerine orange peel, 10 parts of fennel and 12 parts of herba patriniae.
The preparation method of the traditional Chinese medicine composition for treating prostatitis comprises the following steps: decocting the above materials in water twice, wherein the water amount is 10 times of the total weight of the materials, decocting for 2 hr, and the water amount is 8 times of the total weight of the materials, decocting for 1.5 hr, mixing decoctions, concentrating, spray drying, adding adjuvants, and making into Chinese medicinal preparation.
The traditional Chinese medicine composition for treating prostatitis is prepared from one of granules, tablets and capsules.
The traditional Chinese medicine composition for treating prostatitis is chronic prostatitis.
The traditional Chinese medicine composition for treating prostatitis is yin deficiency and fire heat type chronic prostatitis.
The compositions of the invention may also be in the form of solids, solutions, emulsions, dispersions, micelles, liposomes, and other dosage forms. Excipients which may be used include glucose, lactose, gum acacia, gelatin, mannitol, starch paste, magnesium trisilicate, talc, corn starch, keratin, colloidal silica, potato starch, urea, medium chain triglycerides, dextran, and other carriers suitable for use in preparing formulations, solid, semi-solid or liquid forms. In addition, stabilizers, thickeners and colorants and fragrances may also be used as an aid.
The cortex moutan is dried root bark of Paeonia suffruticosa of Ranunculaceae. Produced in Anhui, sichuan, henan and Shandong provinces. Bitter and pungent, slightly cold, and good effects in clearing heat and cooling blood, promoting blood circulation and removing blood stasis, and removing deficiency heat.
The Alismatis rhizoma is dry tuber of Alismatis rhizoma Alisma orientalis (Sam.) Juzep. The stem and leaf are picked up in winter when they begin to wilt, washed, dried and removed the fibrous root and coarse skin. Sweet and light in taste and cold in nature. Enter kidney and bladder meridians. Induce diuresis and excrete dampness, drain heat, resolve turbidity and reduce lipid. Can be used for treating dysuria, edema, distention, diarrhea, oliguria, dizziness due to phlegm and fluid, stranguria due to heat, and hyperlipidemia.
Rhizoma anemarrhenae is dried rhizome of rhizoma anemarrhenae of Liliaceae. Bitter and cold in nature. It enters lung, stomach and kidney meridians. Clear heat and purge fire, nourish yin and moisten dryness. Can be used for treating febrile polydipsia, lung heat dryness cough, hectic fever due to bone steaming, internal heat diabetes, and constipation due to intestinal dryness.
Cortex Phellodendri is dry bark of cortex Phellodendri Phellodendron chinense Schneid of Rutaceae. It is known as Chuan Bai Huang. Removing bark, removing coarse bark, and sun drying. Bitter in flavor and cold in nature. Enter kidney and bladder meridians. Has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic substances, and treating sore. Can be used for treating damp-heat diarrhea, jaundice, dark urine, itching and leukorrhagia, heat stranguria, tinea pedis, night sweat, spermatorrhea, pyocutaneous disease, swelling and toxin, and eczema. Salted phellodendron bark, cortex Phellodendri, radix Phellodendri, has the effect of nourishing yin to reduce pathogenic fire. Is used for treating night sweat and bone steaming due to yin deficiency and fire excess.
The Saviae Miltiorrhizae radix is dry root and rhizome of Saviae Miltiorrhizae radix Salvia miltiorrhiza bge of Labiatae. Collected in spring and autumn, removed sediment, and dried. Distributed throughout most regions of the country. Has effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and resolving carbuncle. Can be used for treating chest pain, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease.
Herba Lycopi is dry aerial part of Labiatae plant Pachyrhizus hirsutus Turcz. Harvesting and sun drying in summer and autumn when the stem and leaf are luxuriant. Distributed in most areas of China. Has effects of promoting blood circulation, regulating menstruation, removing blood stasis, resolving carbuncle, inducing diuresis and relieving swelling. It can be used for treating menoxenia, amenorrhea, dysmenorrhea, puerperal abdominal pain due to blood stasis, sore, carbuncle, toxic swelling, edema, and ascites.
The radix Paeoniae Rubra is dried root of Paeonia lactiflora Pallas or Paeonia suffruticosa of Ranunculaceae. Collected in spring and autumn, removed rhizome, fibrous root and sediment, and dried in the sun. Bitter and slightly cold. Enter liver meridian. Has effects of clearing heat, cooling blood, promoting blood circulation, and removing blood stasis.
Semen Persicae is dry mature seed of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch of Rosaceae. Harvesting after the fruits are ripe, removing pulp and core shells, taking out seeds, and sun-drying. Is cultivated in all places of the country. Has effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, relieving cough and asthma. Can be used for treating amenorrhea dysmenorrhea, abdominal mass, pulmonary abscess, acute appendicitis, traumatic injury, constipation due to intestinal dryness, cough and asthma.
Grass-like perennial herb of Gramineae, araceae, acorus, its rhizome has odor. Has effects in eliminating dampness, stimulating appetite, inducing resuscitation, eliminating phlegm, refreshing mind, and improving intelligence. Can be used for treating gastric fullness, hunger, vomiting, dysentery, unconsciousness, epilepsy, amnesia, and deafness. Regulating qi-flowing, promoting blood circulation, dispelling pathogenic wind, and removing dampness. It can be used for treating epilepsy, phlegm syncope, fever, unconsciousness, amnesia, deafness due to qi obstruction, vexation, gastralgia, abdominal pain, arthralgia due to wind-cold-dampness, carbuncle, swelling and toxic materials, and traumatic injury.
Semen Cuscutae is dried mature seed of south semen Cuscutae Cuscuta australis R.Br. Or Cuscuta chinensis lam. Of Convolvulaceae. Has effects of invigorating liver and kidney, stopping nocturnal emission, reducing urination, preventing miscarriage, improving eyesight, relieving diarrhea, and dispelling pathogenic wind and speckle. Is often used for treating liver and kidney deficiency, soreness of waist and knees, impotence, spermatorrhea, enuresis, frequent urination, kidney deficiency, fetal leakage, fetal movement disorder, dizziness and tinnitus, spleen and kidney deficiency and diarrhea; it is used for treating vitiligo.
Fresh or dried root tuber of rehmannia glutinosa Libosch of Scrophulariaceae. Digging in autumn, removing head, fibrous root and silt, and fresh; or baking rehmanniae radix slowly until it is about eight times dry. The former is known as fresh rehmannia root, the latter is known as Sheng Di Huang. Radix rehmanniae: clear heat and cool blood, nourish yin and promote the production of body fluid. Can be used for treating pyretic diseases, deep-red tongue, polydipsia, yin deficiency, internal heat, bone steaming, internal heat, diabetes, hematemesis, epistaxis, and macula. Prepared rehmannia root: nourishing yin and replenishing blood, replenishing essence and replenishing marrow. Can be used for treating deficiency of liver-yin and kidney-yin, soreness of waist and knees, hectic fever due to bone steaming, night sweat, spermatorrhea, internal heat, diabetes, blood deficiency, sallow complexion, palpitation, menoxenia, metrorrhagia, blood stasis, dizziness, tinnitus, and premature graying of hair and beard.
Semen astragali Complanati is seed of Astragalus membranaceus (Fisch.) bge. Or Astragalus membranaceus (Fisch.) bge. Var. Sinensis (. In the late autumn and early winter, the fruits are cut off when the fruits are ripe and not cracked, the seeds are removed after sun drying, impurities are removed, and then sun drying is carried out. The main functions are as follows: tonify liver, tonify kidney, improve eyesight, arrest spontaneous emission. For treating liver and kidney deficiency, soreness of waist and knees, dizziness, spermatorrhea, premature ejaculation, frequent urination, enuresis, hematuria, and leukorrhagia. (1) Materia medica derived meaning: tonifying kidney. (2) Compendium, compendium: tonify kidney, treat lumbago, release essence, deficiency and fatigue. (3) The materia medica is from new: tonify kidney, strengthen yin, benefit essence and improve eyesight. For treating leukorrhagia, anal fistula and yin-directed bolus. It can secure essence. (4) Medicine codification: kidney-strengthening water, purging pathogenic dampness, and eliminating symptoms of hemorrhoids and fistula. (5) Medical mirror about meeting ]: to prevent enuresis, induce hematuria and reduce urination. (6) Original asking of materia medica: for consumptive lung disease, kidney cold, profuse urine, drowsiness, improving eyesight and growing muscle. It is also indicated for wind-toxin attack of liver and kidney.
Rhizoma Dioscoreae Septemlobae is dried rhizome of Dioscorea septemloba Dioscorea septemloba Thunbt of Dioscoreaceae and Dioscorea zingiberensis Dioscorea hypoglauca Palibin of Dioscoreaceae. Collected in autumn and winter, removed fibrous root, cleaned, sliced and dried in the sun. Bitter in flavor and flat in taste. Enter kidney and stomach meridians. Remove dampness and turbid pathogen, dispel wind and remove arthralgia. Can be used for treating stranguria due to plaster, turbid urine, leukorrhagia, rheumatalgia, joint disorder, and lumbago and gonalgia.
Semen plantaginis is dried mature seed of Plantago asiatica Plantago asiatica L or Plantaginaceae plant Plantago asiatica Willd. Harvesting the ears when the seeds are ripe in summer and autumn, sun-drying, rubbing out the seeds, and removing impurities. Sweet in flavor and cold in nature. Enter liver, kidney, lung and small intestine meridians. Clear heat, induce diuresis, treat stranguria, excrete dampness, stop diarrhea, improve eyesight, eliminate phlegm. Can be used for treating stranguria due to heat, edema, distention, diarrhea due to summer-heat and dampness, conjunctival congestion, swelling and pain, and cough due to phlegm-heat.
Herba Polygoni Avicularis is dry aerial part of herba Polygoni Avicularis Polygonum aviculare L. Harvesting in summer when the leaves are luxuriant, removing roots and impurities, and sun-drying. Bitter in flavor and slightly cold in nature. Enter bladder meridian. Induce diuresis to treat stranguria, kill parasites and relieve itching. It is used for treating stranguria due to heat, oliguria with reddish urine, abdominal pain due to accumulation of parasites, skin eczema, pruritus vulvae, leukorrhagia, etc.
The herba Dianthi is dry aerial part of herba Dianthi Dianthus superbus L or Dianthus chinensis L of herba Dianthi of Caryophyllaceae. Harvesting in summer and autumn, removing impurities, and drying. Bitter in flavor and cold in nature. It enters heart and small intestine meridians. Has effects of promoting urination, treating stranguria, promoting blood circulation, and dredging channels. Is used for treating heat stranguria, blood stranguria, urolithiasis, difficult urination, dribbling and pain, and amenorrhea and yin stasis.
Fructus Toosendan is dried mature fruit of Melia toosendan of Meliaceae. Harvesting in winter, removing impurities, and drying. Bitter and cold in nature. Enter liver, small intestine and bladder meridians. Liver soothing, heat expelling, qi moving, pain relieving, and insect killing effects. Is used for treating liver depression transforming into fire, chest and hypochondrium, abdominal distention and pain, hernia pain, and abdominal pain due to accumulation of parasites.
The green tangerine peel is the peel of dried young fruit or immature fruit of Citrus reticulata Blanco Citrus reticulata Blanco and its cultivar. Bitter and pungent in flavor and warm in nature. It enters liver, gallbladder and stomach meridians. Has effects of dispersing stagnated liver qi, removing qi stagnation, and resolving food stagnation. Can be used for treating chest and hypochondrium distending pain, hernia pain, hyperplasia of mammary glands, acute mastitis, food stagnation, qi stagnation, and abdominal distention and pain.
Fennel is a dried ripe fruit of Foeniculum vulgare Foeniculum vuLgare Mill. Harvesting plants when the autumn fruits are primarily ripe, sun-drying, beating the fruits, and removing impurities. Pungent and warm in nature. It enters liver, kidney, spleen and stomach meridians. Has effects of dispelling cold, relieving pain, regulating qi-flowing and regulating stomach. The salted fructus Foeniculi has effects of warming kidney, dispelling cold and relieving pain. Can be used for treating cold hernia abdominal pain, testicle tenesmus, dysmenorrhea, lower abdomen crymodynia, abdominal distention and pain, anorexia, emesis and diarrhea. Salt fennel is used for treating hernia abdominal pain, testicle deflection and tenesmus, and menstrual cold abdominal pain.
Herba Patriniae is dried whole plant of Patrinia villosa (L.) Bai of Patriniaceae. Cool in nature, pungent and bitter in flavor. Has effects of clearing heat and detoxicating, eliminating phlegm and expelling pus, and is commonly used for treating acute appendicitis, pulmonary abscess, dysentery, postpartum abdominal pain due to blood stasis, carbuncle and furuncle.
The beneficial effects are that:
1. the traditional Chinese medicine composition is used for treating prostatitis from five aspects, namely, the traditional Chinese medicine composition nourishes yin and clears heat, the prostatitis is repeatedly used for treating for a long time and is not healed, and chronic prostatitis is dragged, such as excessive sexual intercourse or strong-tolerance, kidney essence loss, yin deficiency and fire excess and fire delusions; secondly, the blood circulation is activated to remove blood stasis, and the blood is blocked due to the obstruction of collaterals caused by long-term Yu Bu clear damp-heat; thirdly, tonifying kidney and treating stranguria, hyposexuality, impotence and premature ejaculation caused by kidney deficiency; fourthly, clearing heat and promoting diuresis, and the prostate is left due to damp-heat evil, so that the prostate fluid is secreted more and excreted poorly; it is a five-element qi-moving and stagnation-removing herb, and chronic prostatitis often causes qi stagnation and blood stasis.
The inventor clinically forms the overall analysis of the chronic prostatitis, analyzes the current situation of treating the yin deficiency fire heat type chronic prostatitis, recognizes the understanding on the basis of 'clearing heat and promoting diuresis', and repeatedly researches and determines the prescription according to clinical medication if the inventor starts with clearing heat and promoting diuresis and is more deficient. In the formula, cortex moutan, rhizoma alismatis, rhizoma anemarrhenae and cortex phellodendri are taken as principal drugs for nourishing yin and clearing heat, the root of red-rooted salvia, herba lycopi, radix paeoniae rubra and peach kernel are taken as ministerial drugs for activating blood and dissolving stasis, and rhizoma acori graminei, semen cuscutae, radix rehmanniae, prepared rehmannia root, semen astragali complanati, rhizoma dioscoreae septemlobae and semen plantaginis are taken as ministerial drugs for tonifying kidney and treating stranguria; akebia stem, semen plantaginis, polygonum aviculare and fringed pink are used as adjuvant drugs for clearing heat and promoting diuresis, and szechwan chinaberry fruit, green tangerine peel, common fennel fruit and herba patriniae are used as guiding drugs for promoting qi circulation and removing stagnation. The whole formula has the effects of nourishing yin, clearing heat, promoting blood circulation, removing blood stasis, tonifying kidney, treating stranguria, clearing heat, promoting diuresis, promoting qi circulation, and removing stagnation, and has good effect on yin deficiency and fire heat type chronic prostatitis.
2. Experimental results show that the invention is applicable to standard strains: staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, and clinically isolated strains: staphylococcus aureus, escherichia coli and pseudomonas aeruginosa have antibacterial effects, and the antibacterial effect of the embodiment 1 is close to that of a positive medicine, so that the formula is reasonable, and the effect is better.
3. Experimental results show that the group 2 of the traditional Chinese medicine composition provided by the invention can reduce ear swelling of mice caused by the balm oil, and has a significant difference (P < 0.05) compared with a physiological saline group, which indicates that the traditional Chinese medicine composition provided by the invention has an obvious anti-inflammatory effect.
4. Experimental results show that the traditional Chinese medicine composition can remarkably inhibit the increase of capillary permeability of mice caused by acetic acid (P is less than 0.05), and has the effects of inhibiting inflammatory exudation and resisting inflammation, and has good effect.
Detailed Description
The above-described matters of the present invention will be further described in detail by way of examples, but it should not be construed that the scope of the above-described subject matter of the present invention is limited to the following examples, and all techniques realized based on the above-described matters of the present invention are within the scope of the present invention.
Example 1: 23 parts of cortex moutan, 14 parts of rhizoma alismatis, 14 parts of rhizoma anemarrhenae, 10 parts of cortex phellodendri, 12 parts of radix salviae miltiorrhizae, 13 parts of herba lycopi, 12 parts of radix paeoniae rubra, 8 parts of peach kernel, 15 parts of rhizoma acori graminei, 12 parts of semen cuscutae, 13 parts of radix rehmanniae, 15 parts of prepared rehmannia root, 12 parts of semen astragali complanati, 12 parts of rhizoma dioscoreae, 13 parts of semen plantaginis, 13 parts of polygonum aviculare, 18 parts of fringed pink, 10 parts of szechwan chinaberry fruit, 14 parts of green tangerine orange peel, 13 parts of fennel and 10 parts of herba patriniae, and the steps of water decoction are taken for two times, wherein the water adding amount is 10 times of the total weight of the medicinal materials, the water adding amount is 2 hours, the water adding amount for the second time is 8 times of the total weight of the medicinal materials, the water adding is 1.5 hours, the decoction liquid is combined, concentrated, spray dried, and the proper amount of starch is added, and tabletting is carried out.
Example 2: 20 parts of cortex moutan, 16 parts of rhizoma alismatis, 12 parts of rhizoma anemarrhenae, 12 parts of cortex phellodendri, 8 parts of radix salviae miltiorrhizae, 16 parts of herba lycopi, 10 parts of radix paeoniae rubra, 10 parts of peach kernel, 10 parts of rhizoma acori graminei, 16 parts of semen cuscutae, 10 parts of radix rehmanniae, 18 parts of prepared rehmannia root, 8 parts of semen astragali complanati, 14 parts of rhizoma dioscoreae, 10 parts of semen plantaginis, 16 parts of polygonum aviculare, 15 parts of fringed pink, 14 parts of fructus toosendan, 12 parts of green tangerine peel, 16 parts of fennel and 8 parts of herba patriniae, and the water is added for decoction twice, wherein the water adding amount is 10 times of the total weight of the medicinal materials, the decoction is 2 hours, the water adding amount for the second time is 8 times of the total weight of the medicinal materials, the decoction is 1.5 hours, the decoction is combined, concentrated, spray dried, and the right amount of dextrin is added, and hard capsules are filled.
Example 3: 26 parts of cortex moutan, 10 parts of rhizoma alismatis, 18 parts of rhizoma anemarrhenae, 8 parts of cortex phellodendri, 16 parts of radix salviae miltiorrhizae, 10 parts of herba lycopi, 14 parts of radix paeoniae rubra, 6 parts of peach kernel, 20 parts of rhizoma acori graminei, 8 parts of semen cuscutae, 16 parts of radix rehmanniae, 12 parts of prepared rehmannia root, 14 parts of semen astragali complanati, 8 parts of rhizoma dioscoreae, 16 parts of semen plantaginis, 10 parts of polygonum aviculare, 20 parts of fringed pink, 8 parts of fructus toosendan, 18 parts of green tangerine orange peel, 10 parts of fennel and 12 parts of herba patriniae, and the preparation method comprises the steps of decocting the raw materials twice with water, wherein the water adding amount is 10 times of the total weight of the medicinal materials, decocting the raw materials for 2 hours, the water adding amount of the second time is 8 times of the total weight of the medicinal materials, decocting the raw materials for 1.5 hours, merging the decoction, concentrating, spray drying, and crushing the dried extract powder, and preparing the granule.
Example 4: pharmacodynamics research of the traditional Chinese medicine composition for treating prostatitis
1. Medicine and reagent: in the traditional Chinese medicine composition examples 1, 2 and 3, the medicinal material extract is subjected to spray drying, and distilled water is used for preparing the concentration required by a suspension solution (0.2 g crude drug/ml calculated by crude drug). Qianjin Kang Enbei Qianliekang, produced by pharmaceutical Co., ltd., weight of each tablet is 0.57g (0.5 g containing rape pollen), lot 20200801.
2. Animals: ICR mice, provided by the university of Nanjing traditional Chinese medicine laboratory animal center, qualification certificate: threo 2018040.
3. Strains and viruses: standard strain: staphylococcus aureus, escherichia coli, pseudomonas aeruginosa (28001), provided by the department of health microbiology; clinical isolation of strains: staphylococcus aureus, escherichia coli and pseudomonas aeruginosa are identified by the microbiological laboratory of the people's hospitals in Jiangsu province.
4. Antibacterial effect of the Chinese medicinal composition
Taking nutrient broth (6 hr culture) as 10 -3 Diluting for experiments, adding 1mL of bacterial liquid into a sterilization culture dish (diameter 9 cm), pouring 20mL of nutrient agar culture medium (dissolved and cooled to 45 ℃), rotating and uniformly mixing, punching 3 holes on the agar plate by using a sterilization steel tube (with outer diameter of 6 mm) after solidification, taking out the culture medium in the holes by using sterile forceps, adding 0.05m1 of different example 1 medicines (1.00 g/mL) into each hole, culturing for 20 hours (37 ℃), taking out and measuring the diameter of a fungus ring, carrying out each experiment twice, and taking an average value, wherein the results are shown in tables 1 and 2.
TABLE 1 diameter (mm) of inhibition zone of the present invention on standard strain (plate hole punching method)
Group of | Staphylococcus aureus | Coli bacterium | Pseudomonas aeruginosa |
The front column Kang Zu | 15.0 | 18.0 | 16.0 |
Example 1 group | 19.0 | 20.0 | 21.0 |
TABLE 2 diameter (mm) of inhibition zone of clinically isolated strains of the invention (plate hole punching method)
Group of | Staphylococcus aureus | Coli bacterium | Pseudomonas aeruginosa |
The front column Kang Zu | 26.5 | 21.0 | 18.5 |
Example 1 group | 25.0 | 20.0 | 21.0 |
Experimental results show that the invention is applicable to standard strains: staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, and clinically isolated strains: staphylococcus aureus, escherichia coli and pseudomonas aeruginosa have antibacterial effects, and the antibacterial effect of the embodiment 1 is close to that of a positive medicine, so that the formula is reasonable, and the effect is better.
5. Research on influence of traditional Chinese medicine composition on ear swelling of mice
Male mice (26-30 g) were randomly divided into three groups, 10 in each group, namely example 2 group (20 g/kg), prostacyclin group (20 g/kg), physiological saline group (20 ml/kg), and administered by stomach irrigation, 1 time per day, 3 days continuously, 30min after last administration, 0.05ml of 2% croton oil was applied to both sides of left ear of the mice, and after 4h, the mice were sacrificed by removing vertebrae, and left and right ears were cut. Then, the round lugs were removed from the same positions with a punch (diameter: 9 mm), and the weight of the shells was calculated by weighing with a torsion balance, and the results are shown in Table 3.
TABLE 3 Effect of the invention on ear swelling in mice (X.+ -. S) due to croton oil
Group of | Quantity of | Ear swelling degree (mg) |
Physiological saline group | 10 | 12.5±3.7 |
The front column Kang Zu | 10 | 9.6±3.2* |
Example 2 group | 10 | 7.8±4.1* |
* P < 0.05P <0.01 compared to saline group
Experimental results show that the group 2 of the traditional Chinese medicine composition provided by the invention can reduce ear swelling of mice caused by the balm oil, and has a significant difference (P < 0.05) compared with a physiological saline group, which indicates that the traditional Chinese medicine composition provided by the invention has an obvious anti-inflammatory effect.
6. The influence of the Chinese medicinal composition on the increase of the capillary permeability of the abdominal cavity of the mouse
Taking 50 mice, weighing 18-22 g, randomly dividing the mice into 3 groups, namely a blank control group, a prostate health positive drug control group, a group of the invention of the embodiment 3, and then each group is given with a corresponding composition of the invention (the oral gastric lavage dosage is 20 g/kg/d), wherein the positive control group is given with gastric lavage prostate health 20g/kg/d; the blank control group was given an equal volume of physiological saline 1 time per day with a volume of 20ml/kg for 3 consecutive days, 1h after the last administration, each group of mice was given 0.5% by intravenous injection of Evan's blue physiological saline solution 0.1ml/10g body weight, then immediately and intraperitoneally 0.6% by acetic acid 0.2 ml/1, after 20min, the mice were sacrificed by cervical vertebrae removal, the abdominal cavity was dissected, washed several times with 5ml physiological saline, the wash was collected to a volume of 10ml, centrifuged at 1000rpm x 5min, the supernatant was taken, OD values were measured at 590nm of the spectrophotometer, and differences between the groups were compared. The results are shown in Table 4.
TABLE 4 Effect of the invention on acetic acid-induced increases in capillary permeability in the abdominal cavity of mice (X.+ -. S)
Group of | Quantity of | OD value |
Physiological saline group | 10 | 0.421±0.074 |
The front column Kang Zu | 10 | 0.332±0.064* |
Example 3 group | 10 | 0.282±0.052* |
Note that: p <0.05, P <0.01 compared to saline group
The results in table 4 show that: the traditional Chinese medicine composition can obviously inhibit the increase of capillary permeability of mice caused by acetic acid (P is less than 0.05), and has the effects of inhibiting inflammatory exudation and resisting inflammation, and has good effect.
Example 5: clinical test data of the traditional Chinese medicine composition for treating yin deficiency fire heat type prostatitis
General data of subjects: the traditional Chinese medicine composition disclosed by the invention is used for treating 100 cases of yin deficiency and fire heat type chronic prostatitis, and is used for treating all men in the age of 48 years for the elderly and 25 years for the least.
Diagnostic criteria: it is mainly manifested by frequent urination, urination burning, spermatorrhea, premature ejaculation, premature urination with white urine or with blood essence, dizziness, tinnitus, dry mouth and throat, dysphoria with feverish sensation in the chest, red tongue with little coating, and thready and rapid pulse. The prostate gland is not large in volume, which indicates that the prostate is irregular, hard in texture and free from tenderness. Examination of the prostatic fluid can reveal leukocytosis, and the lecithin corpuscles are obviously reduced or eliminated.
Efficacy evaluation criteria: and (3) curing: after treatment, the bacterial culture result of the prostatic fluid is negative, microscopic examination shows that WBC is lower than 10/HP, and patients have no subjective symptoms; the method is effective: after treatment, the bacterial culture result of the prostatic fluid is negative, and microscopic examination shows that WBC is lower than 10/HP, and the subjective symptoms of patients are obviously improved; invalidation: after treatment, the bacterial culture result of the prostatic fluid is positive, and microscopic examination shows that WBC is more than 10/HP, and the subjective symptoms of the patients are not improved.
The treatment method comprises the following steps: the usage amount is as follows: the granule prepared in the embodiment 3 of the invention has the usage and dosage of 2 bags each time, each bag is 10g, the granule is taken with warm water 3 times a day, one week is a treatment course, and the total treatment course is 4.
The experimental results are shown in Table 5.
Table 5 statistics of the effects of each group
Curative effect | Healing | Effective and effective | Invalidation of | Total effective rate |
70 | 25 | 5 | 95% |
In conclusion, the traditional Chinese medicine composition has remarkable effects of treating yin deficiency and fire heat type chronic prostatitis when the traditional Chinese medicine composition is used for treating the rules of treatment of yin deficiency and heat clearing, blood circulation activating, blood stasis removing, kidney tonifying, stranguria treating, heat clearing, dampness removing, qi activating and stagnation removing.
The present invention is, of course, not limited to the above-described embodiments, and one skilled in the art can make equivalent modifications or substitutions without departing from the spirit of the invention, which are intended to be included in the scope of the present invention as defined in the appended claims.
Claims (6)
1. The traditional Chinese medicine composition for treating prostatitis is characterized by being prepared from the following raw materials in parts by weight through extraction: 20-26 parts of moutan bark, 10-16 parts of rhizoma alismatis, 12-18 parts of rhizoma anemarrhenae, 8-12 parts of cortex phellodendri, 8-16 parts of radix salviae miltiorrhizae, 10-16 parts of herba lycopi, 10-14 parts of radix paeoniae rubra, 6-10 parts of peach kernel, 10-20 parts of rhizoma acori graminei, 8-16 parts of semen cuscutae, 10-16 parts of radix rehmanniae, 12-18 parts of prepared rehmannia root, 8-14 parts of semen astragali complanati, 8-14 parts of rhizoma dioscoreae septemlobae, 10-16 parts of semen plantaginis, 10-16 parts of polygonum aviculare, 15-20 parts of fringed pink, 8-14 parts of szechwan chinaberry fruit, 12-18 parts of green tangerine peel, 10-16 parts of fennel and 8-12 parts of herba patriniae.
2. The traditional Chinese medicine composition for treating prostatitis according to claim 1 is characterized by being prepared from the following raw materials in parts by weight through extraction: 23 parts of moutan bark, 14 parts of rhizoma alismatis, 14 parts of rhizoma anemarrhenae, 10 parts of cortex phellodendri, 12 parts of radix salviae miltiorrhizae, 13 parts of herba lycopi, 12 parts of radix paeoniae rubra, 8 parts of peach kernel, 15 parts of rhizoma acori graminei, 12 parts of semen cuscutae, 13 parts of radix rehmanniae, 15 parts of prepared rehmannia root, 12 parts of semen astragali complanati, 12 parts of rhizoma dioscoreae, 13 parts of semen plantaginis, 13 parts of polygonum aviculare, 18 parts of herba dianthi, 10 parts of fructus toosendan, 14 parts of green tangerine peel, 13 parts of fennel and 10 parts of herba patriniae.
3. The traditional Chinese medicine composition for treating prostatitis according to claim 1 is characterized by being prepared from the following raw materials in parts by weight through extraction: 20 parts of moutan bark, 16 parts of rhizoma alismatis, 12 parts of rhizoma anemarrhenae, 12 parts of cortex phellodendri, 8 parts of radix salviae miltiorrhizae, 16 parts of herba lycopi, 10 parts of radix paeoniae rubra, 10 parts of peach kernel, 10 parts of rhizoma acori graminei, 16 parts of semen cuscutae, 10 parts of radix rehmanniae, 18 parts of prepared rehmannia root, 8 parts of semen astragali complanati, 14 parts of rhizoma dioscoreae, 10 parts of semen plantaginis, 16 parts of polygonum aviculare, 15 parts of herba dianthi, 14 parts of fructus toosendan, 12 parts of green tangerine orange peel, 16 parts of fennel and 8 parts of herba patriniae.
4. The traditional Chinese medicine composition for treating prostatitis according to claim 1 is characterized by being prepared from the following raw materials in parts by weight through extraction: 26 parts of moutan bark, 10 parts of rhizoma alismatis, 18 parts of rhizoma anemarrhenae, 8 parts of cortex phellodendri, 16 parts of radix salviae miltiorrhizae, 10 parts of herba lycopi, 14 parts of radix paeoniae rubra, 6 parts of peach kernel, 20 parts of rhizoma acori graminei, 8 parts of semen cuscutae, 16 parts of radix rehmanniae, 12 parts of prepared rehmannia root, 14 parts of semen astragali complanati, 8 parts of rhizoma dioscoreae, 16 parts of semen plantaginis, 10 parts of polygonum aviculare, 20 parts of herba dianthus superbus, 8 parts of fructus toosendan, 18 parts of green tangerine orange peel, 10 parts of fennel and 12 parts of herba patriniae.
5. The traditional Chinese medicine composition for treating prostatitis according to any one of claims 1 to 4, wherein the preparation method comprises the following steps: decocting the above materials in water twice, wherein the water amount is 10 times of the total weight of the materials, decocting for 2 hr, and the water amount is 8 times of the total weight of the materials, decocting for 1.5 hr, mixing decoctions, concentrating, spray drying, adding adjuvants, and making into Chinese medicinal preparation.
6. The traditional Chinese medicine composition for treating prostatitis according to claim 5, wherein the dosage form of the traditional Chinese medicine preparation is one of granules, tablets and capsules.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210695104.3A CN114949108B (en) | 2022-06-20 | 2022-06-20 | Traditional Chinese medicine composition for treating prostatitis and preparation method and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210695104.3A CN114949108B (en) | 2022-06-20 | 2022-06-20 | Traditional Chinese medicine composition for treating prostatitis and preparation method and application thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN114949108A CN114949108A (en) | 2022-08-30 |
CN114949108B true CN114949108B (en) | 2023-07-28 |
Family
ID=82963930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210695104.3A Active CN114949108B (en) | 2022-06-20 | 2022-06-20 | Traditional Chinese medicine composition for treating prostatitis and preparation method and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114949108B (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103070995A (en) * | 2012-12-30 | 2013-05-01 | 李江 | Traditional Chinese medicine for curing prostatitis |
CN107184767A (en) * | 2017-05-31 | 2017-09-22 | 马国坚 | Formula and pharmaceutical methods that a kind of field pennycress Chinese herbal medicine is cured the disease |
-
2022
- 2022-06-20 CN CN202210695104.3A patent/CN114949108B/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN114949108A (en) | 2022-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101954011B (en) | Chinese medicinal preparation for treating urethritis | |
CN104383134A (en) | Traditional Chinese medicine preparation for treating phlebotomized wound infection and production method of traditional Chinese medicine preparation | |
CN106421673A (en) | Traditional Chinese medicine composition for treating HPV (human papillomavirus) infection and preparation method thereof | |
CN109549958B (en) | Composition for treating hormone-dependent dermatitis and preparation method thereof | |
CN112546178A (en) | Traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease and preparation method thereof | |
CN114949108B (en) | Traditional Chinese medicine composition for treating prostatitis and preparation method and application thereof | |
CN104840596A (en) | Traditional Chinese medicine for treating qi-blood deficient cervical carcinoma and preparation method of traditional Chinese medicine | |
CN103055078B (en) | Traditional Chinese medicine for treating ascites hepatoma and preparation method thereof | |
CN104998197A (en) | Traditional Chinese medicine composition for treating liver cancer | |
CN104984292A (en) | Medicine composition for treating mycoplasmal pneumonia and preparation method thereof | |
CN104758900A (en) | Traditional Chinese medicine for treating acute pancreatitis | |
CN103386101B (en) | Traditional Chinese medicine preparation for nonspecific cystitis treatment and preparation method thereof | |
CN107823303B (en) | Zhuang-nationality-medicine external fumigation-washing soup for treating haemorrhoids | |
CN105709101A (en) | Traditional Chinese medicine preparation for treating blepharitis ciliaris and preparation method thereof | |
CN106902306B (en) | Traditional Chinese medicine for treating kidney deficiency and blood stasis type benign prostatic hyperplasia bladder detrusor dysfunction and preparation method thereof | |
CN104940752A (en) | Chinese medicine preparation for treating vulva ulcer and preparing method thereof | |
CN104940617A (en) | Traditional Chinese medicine for treatment of qi-stagnation and blood stasis type chronic pyelonephritis and preparation method | |
CN104547715A (en) | Traditional Chinese medicine for treating stomach heat abundant accumulation type acute mastitis and preparation method thereof | |
CN104257871B (en) | Scorching pharmaceutical composition of the acute lymphatic meshwork of type and preparation method thereof is accumulate for treating damp and hot poison | |
CN103656355B (en) | Medicine being used for the treatment of swine paratyphoid and preparation method thereof | |
CN107753800A (en) | A kind of Chinese medicine composition for treating chronic pelvic inflammatory disease and preparation method thereof | |
CN106237206A (en) | A kind of Chinese medicine preparation treating tumor and preparation method thereof | |
CN105012789A (en) | Composition for treating cervical cancer and preparation method thereof | |
CN104383467A (en) | Traditional Chinese medicine for treating liver-qi depression type cervical cancer and preparation method of traditional Chinese medicine | |
CN103520403B (en) | Traditional Chinese medicine for treating type II diabetes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Huang Yuyu Inventor after: Tang Liang Inventor after: Hu Fang Inventor after: Chen Ting Inventor before: Tang Liang Inventor before: Hu Fang Inventor before: Chen Ting |
|
GR01 | Patent grant | ||
GR01 | Patent grant |