CN104984292A

CN104984292A - Medicine composition for treating mycoplasmal pneumonia and preparation method thereof

Info

Publication number: CN104984292A
Application number: CN201510424798.7A
Authority: CN
Inventors: 吴强
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-20
Filing date: 2015-07-20
Publication date: 2015-10-21

Abstract

The invention discloses a medicine composition for treating mycoplasmal pneumonia and a preparation method thereof. The medicine composition comprises the raw materials of lobelia, herbs of threeflower bluebeard, fructus aurantii, great burdock achene, stemona tubers, balloon flowers, meadowrue roots and rhizomes, heartleaf houttuynia herbs, liquorice, Japanese ardisia, Japanese metaplexis, Indian Kalimeris herbs, ginger, thorny elaeagnus fruits, magnetite, Russian boschniakia herbs, bamboo juice, plantain seeds, white mustard seeds, narrow-leaf lepisorus, tabasheer, perilla fruits, agilawood, white mulberry root-bark, raspberries, immature fruits of medicine terminalia, pepperweed seeds, sharpleaf galangal fruits, pennycress, woody hawkbeard roots, wallich eriophyton and lemmaphyllum subrostratum. The medicine composition has the advantages that the effects of clearing away heat through releasing the lungs, regulating the lungs, relieving asthma and reducing phlegm are achieved, meanwhile, the effects of tonifying the kidneys, removing blood stasis, promoting urination and replenishing vital essence to cultivate qi are achieved, the medicine composition takes effect rapidly, is high in effective rate and free of toxic and side effects and has a definite treatment effect, the treatment course is short, and the price is low.

Description

A kind of pharmaceutical composition for the treatment of mycoplasma pneumoniae pneumonia and preparation method thereof

Technical field

The present invention relates to technical field of medicine, particularly a kind of pharmaceutical composition for the treatment of mycoplasma pneumoniae pneumonia and preparation method thereof.

Background technology

Mycoplasma pneumoniae pneumonia is caused from mycoplasma pneumoniae to become main acute pulmonary infection with ID, the pneumonia caused with common bacterias such as streptococcus pneumoniae in clinical manifestation due to this parapneumonia has obvious difference, and beta-lactam antibiotic and sulfa drugs etc. are failed to respond to any medical treatment, therefore again the pneumonia that other atypical pathogens such as itself and legionella pneumophilia, Chlamydia pneumoniae and rickettsia cause is referred to as " primary atypical pneumonia " clinically.Discovered in recent years atypical pathogens especially mycoplasma pneumoniae has been the Main Pathogenic Bacteria of community acquired pneumonia.

The symptom of mycoplasma pneumoniae pneumonia: 2 ~ 3 weeks incubation periods, onset is slow, and about 1/3 case is asymptomatic.Occur with the form of arm-bronchitis, pneumonia, ear drum membrane inflammation etc., and the heaviest with pneumonia.Morbidity just has weak, headache, pharyngalgia, feels cold, generate heat, muscular soreness, loss of appetite, Nausea and vomiting etc., has a headache remarkable.Heating height differs, can up to 39 DEG C.There is obvious respiratory symptom after 2 ~ 3 days, as paroxysmal irritable cough, cough a small amount of sticky expectorant or mucopurulent sputum, sometimes sputum mixed with blood.Generate heat sustainable 2 ~ 3 weeks.Temperature is recovered still can lose cough normally, pain under companion's breastbone, but without chest pain.Mild nasal congestion, watery nasal discharge are shown in health check-up, and pharynx moderate is congested.Ear drum membrane often has hyperemia, and about 15% has myringitis.Lymphonodi cervicales can enlargement.Minority case has maculopapule, erythema or herpes labialis.The general Non Apparent Abnormality sign of chest, about half audible dryness or moist rale, there is a small amount of hydrothorax in about 10% ~ 15% case.The state of an illness is general comparatively light, sometimes can weigh, but seldom dead.Generate heat 3 days to 2 weeks, cough can extend to about 6 weeks.Have 10% recurrence, pneumonia sees same leaf or same leaf, and the cold agglutination titer of a few patients erythrocyte is tired more than 1: 500.Suitable intravascular hemolysis can be had, when haemolysis often sees and brings down a fever, or betide when suffering from cold.Only a few case can occur together nervus centralis symptom, and such as meningitis, meningoencephalitis, mostly occur radiculitis, even Mental Subnormality etc.Hemorrhagic ear drum membrane inflammation, gastroenteritis, arthritis, thrombocytopenic purpura, hemolytic anemia, pericarditis, myocarditis, hepatitis are also found.

The pathogenesis of mycoplasma pneumoniae pneumonia: mycoplasma pneumoniae is between antibacterial and virus, the minimum microorganism that can live on one's own life, size is 200nm.Acellular wall, only by the cell membrane be made up of 3 tunics, often obscure mutually with the l type of antibacterial, both bacterium colonies are similar, can grow and schizogamy, containing rna and dna, through metabolism produce power, to antibiotic sensitive in acellular culture medium.Mycoplasma is the pathogen of animal various diseases, has found 8 types at present, wherein only has mycoplasma pneumoniae certainly to cause a disease to people, mainly respiratory system disease.Well-grown on the agar culture medium of 20% horse serum and yeast, under being incubated at microscope for the first time, visible typical in dome-shaped Fructus Mori shape bacterium colony, transmit fried egg shape after repeatedly going down to posterity.Mycoplasma fermentans glucose, has hemadsorption (hemadsorption) effect, dissolves the erythrocyte of Cavia porcellus, sheep, to tool resistances such as methylene blue, thaliium acetate, penicillins.Finally serological diagnosis need be made.It is by mouth, nasal discharge air-borne transmission, causes and distributes and little popular respiratory tract infection, be mainly seen in Children and teenager, and find now also non-rare in adult, autumn and winter is more.Respiratory tract infection has pharyngitis and bronchitis, and minority involves lung.Mycoplasma pneumonia accounts for more than 1/3 of non-bacterial pneumonia, or 10% of various pneumonia.

The complication of mycoplasma pneumoniae pneumonia: only a few case can occur together nervus centralis symptom, such as meningitis, meningoencephalitis, mostly occur radiculitis, even Mental Subnormality etc.Hemorrhagic ear drum membrane inflammation, gastroenteritis, arthritis, thrombocytopenic purpura, hemolytic anemia, pericarditis, myocarditis, hepatitis are also found.

The traditional Chinese medical science is thought, the disease of this class of mycoplasma pneumonia, and it is marked on lung, and base will at kidney.In other words, seem that cough is pulmonary disease, but essence is suffered from a deficiency of the kidney, lung master exhale, the main suction of kidney, lung governing diffusion, kidney governing inspiration.When the state of an illness is hurried, with lung qi dispersing heat clearing away, relieving asthma, eliminating phlegm for controlling, during disease amelioration with the kidney invigorating, improving inspiration by invigorating kidney-QI, benefit essence, foster the spirit of nobility as controlling.

Current western medical treatment method is: 1, general treatment respiratory tract isolation, has a rest, supplies enough moisture and nutrition.Symptomatic treatment: avoid with Salicylates in case haemolysis.Generally select and have slowly and the antipyretic analgesic of dauer effect, as to acetyl phenol, carbasalate calcium, rely ammonia than woods, Radix Bupleuri etc., be aided with Physical temperature-lowering during high heat.Preventing phlegm from forming and stopping coughing.Remove nasal secretion, keep respiratory passage unblocked.Aerosolizable suction if desired.2, antibacterial therapy: clinical first-selected erythromycin 30 ~ 50mg/ (kg d), points 4 times oral, adult 1.5g/d, and points 3 times oral, 2 ~ 3 weeks courses for the treatment of.Macrolide new drug, as Roxithromycin, gastrointestinal side-effect is few, and body-fluid concentration is high, and cell-penetrating power is strong, long half time, and consumption is little, 5mg ~ 10mg/ (kgd), and points 2 times oral.New drug azithromycin capsule first dose of 10mg/ (kgd), later 5mg/ (kgd), once oral, within 5 days, be a course for the treatment of.Because of long half time, still sustainable 1 week of drug effect after drug withdrawal.Also norfloxacin or each 0.4g of ciprofloxacin is selected, 2 times/d, 5 ~ 7 days courses for the treatment of.Above-mentioned western medicine side effect is: gastrointestinal reaction, hepatic injury, allergic drug eruption, medicine heat, central nervous system toxicity, photosensitivity reaction, cardiac toxicity etc.

The suitable antibacterials of early application can mitigation symptoms and shorten the course of disease, Macrolide antibacterials be first-selection, as erythromycin, Roxithromycin and azithromycin.Fluoroquinolones is as levofloxacin, Gatifloxacin and Moxifloxacin etc., and Tetracyclines is also for the treatment of mycoplasma pneumoniae pneumonia.General 2 ~ 3 weeks of the course for the treatment of.Use western medicine mycoplasma pneumoniae pneumonia not only treatment time long, and side effect is by force, affects the growth of child, therefore finds successful, short treating period and the medicine had no side effect is problem demanding prompt solution.From traditional medicine, find active active drug that is strong, that have no side effect become the new way solving this problem.

Summary of the invention

Technical problem to be solved by this invention is, a kind of pharmaceutical composition for the treatment of mycoplasma pneumoniae pneumonia and preparation method thereof is provided, the present invention has benefiting QI and nourishing blood, effect of regulating qi-flowing for strengthening spleen and warming and recuperating the kidney-YANG, have the effect of strong muscles and bones, liver and kidney tonifying and bone strengthening pain relieving concurrently, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition for the treatment of mycoplasma pneumoniae pneumonia, wherein, following raw medicinal material is comprised: Herba Lobeliae Sessilifoliae, Herba Caryopteridis Terniflorae, Fructus Aurantii, Fructus Arctii, Radix Platycodonis, Radix et Rhizoma Thalictri, Herba Houttuyniae, Radix Glycyrrhizae, Herba Ardisiae Japonicae, Rhizoma Zingiberis Recens, Fructus Elaeagni, Magnetitum, Herba Boschniakiae Rossicae, Succus Bambusae, Semen Plantaginis, Semen Sinapis Albae, halberd Ye Wawei, Fructus Perillae, Lignum Aquilariae Resinatum, Cortex Mori, Fructus Rubi, Fructus chebulae immaturus, Semen Lepidii (Semen Descurainiae), Fructus Alpiniae Oxyphyllae, Herba Thlaspis, Radix Crepidis Ligneae and dominoes Herba pteridii latiusculi.

In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 3 ~ 5 parts, Herba Caryopteridis Terniflorae 10 ~ 20 parts, Fructus Aurantii 15 ~ 35 parts, Fructus Arctii 12 ~ 22 parts, Radix Platycodonis 11 ~ 31 parts, Radix et Rhizoma Thalictri 15 ~ 45 parts, Herba Houttuyniae 14 ~ 34 parts, 10 ~ 20 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 12 ~ 36 parts, 10 ~ 20 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 12 ~ 38 parts, Magnetitum 10 ~ 20 parts, Herba Boschniakiae Rossicae 11 ~ 32 parts, Succus Bambusae 10 ~ 30 parts, Semen Plantaginis 15 ~ 35 parts, Semen Sinapis Albae 10 ~ 20 parts, halberd Ye Wawei 12 ~ 32 parts, Fructus Perillae 10 ~ 20 parts, Lignum Aquilariae Resinatum 14 ~ 28 parts, Cortex Mori 15 ~ 35 parts, Fructus Rubi 10 ~ 22 parts, Fructus chebulae immaturus 15 ~ 30 parts, Semen Lepidii (Semen Descurainiae) 10 ~ 40 parts, Fructus Alpiniae Oxyphyllae 10 ~ 20 parts, Herba Thlaspis 10 ~ 35 parts, Radix Crepidis Ligneae 10 ~ 22 parts and dominoes Herba pteridii latiusculi 10 ~ 30 parts.

In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 3 parts, Herba Caryopteridis Terniflorae 12 parts, Fructus Aurantii 16 parts, Fructus Arctii 22 parts, Radix Platycodonis 30 parts, Radix et Rhizoma Thalictri 42 parts, Herba Houttuyniae 33 parts, 15 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 34 parts, 15 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 35 parts, Magnetitum 14 parts, Herba Boschniakiae Rossicae 30 parts, Succus Bambusae 20 parts, Semen Plantaginis 35 parts, Semen Sinapis Albae 12 parts, halberd Ye Wawei 28 parts, Fructus Perillae 15 parts, Lignum Aquilariae Resinatum 20 parts, Cortex Mori 35 parts, Fructus Rubi 16 parts, Fructus chebulae immaturus 20 parts, Semen Lepidii (Semen Descurainiae) 30 parts, Fructus Alpiniae Oxyphyllae 13 parts, Herba Thlaspis 32 parts, Radix Crepidis Ligneae 22 parts and dominoes Herba pteridii latiusculi 26 parts.

In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 4 parts, Herba Caryopteridis Terniflorae 16 parts, Fructus Aurantii 32 parts, Fructus Arctii 22 parts, Radix Platycodonis 14 parts, Radix et Rhizoma Thalictri 42 parts, Herba Houttuyniae 33 parts, 15 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 28 parts, 17 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 35 parts, Magnetitum 13 parts, Herba Boschniakiae Rossicae 24 parts, Succus Bambusae 18 parts, Semen Plantaginis 26 parts, Semen Sinapis Albae 15 parts, halberd Ye Wawei 30 parts, Fructus Perillae 14 parts, Lignum Aquilariae Resinatum 23 parts, Cortex Mori 32 parts, Fructus Rubi 20 parts, Fructus chebulae immaturus 30 parts, Semen Lepidii (Semen Descurainiae) 40 parts, Fructus Alpiniae Oxyphyllae 16 parts, Herba Thlaspis 33 parts, Radix Crepidis Ligneae 17 parts and dominoes Herba pteridii latiusculi 27 parts.

In described pharmaceutical composition, each raw medicinal material also comprises: Pericarpium Metaplexis, Herba Kalimeridis, the Radix Stemonae, polished rod fine jade and Concretio Silicea Bambusae.

In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 3 ~ 5 parts, Herba Caryopteridis Terniflorae 10 ~ 20 parts, Fructus Aurantii 15 ~ 35 parts, Fructus Arctii 12 ~ 22 parts, Radix Platycodonis 11 ~ 31 parts, Radix et Rhizoma Thalictri 15 ~ 45 parts, Herba Houttuyniae 14 ~ 34 parts, 10 ~ 20 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 12 ~ 36 parts, 10 ~ 20 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 12 ~ 38 parts, Magnetitum 10 ~ 20 parts, Herba Boschniakiae Rossicae 11 ~ 32 parts, Succus Bambusae 10 ~ 30 parts, Semen Plantaginis 15 ~ 35 parts, Semen Sinapis Albae 10 ~ 20 parts, halberd Ye Wawei 12 ~ 32 parts, Fructus Perillae 10 ~ 20 parts, Lignum Aquilariae Resinatum 14 ~ 28 parts, Cortex Mori 15 ~ 35 parts, Fructus Rubi 10 ~ 22 parts, Fructus chebulae immaturus 15 ~ 30 parts, Semen Lepidii (Semen Descurainiae) 10 ~ 40 parts, Fructus Alpiniae Oxyphyllae 10 ~ 20 parts, Herba Thlaspis 10 ~ 35 parts, Radix Crepidis Ligneae 10 ~ 22 parts, dominoes Herba pteridii latiusculi 10 ~ 30 parts, Pericarpium Metaplexis 13 ~ 26 parts, Herba Kalimeridis 11 ~ 21 parts, the Radix Stemonae 3 ~ 4 parts, 14 ~ 28 parts, polished rod fine jade and Concretio Silicea Bambusae 10 ~ 40 parts.

In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 4 parts, Herba Caryopteridis Terniflorae 16 parts, Fructus Aurantii 32 parts, Fructus Arctii 22 parts, Radix Platycodonis 14 parts, Radix et Rhizoma Thalictri 42 parts, Herba Houttuyniae 33 parts, 15 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 28 parts, 17 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 35 parts, Magnetitum 13 parts, Herba Boschniakiae Rossicae 24 parts, Succus Bambusae 18 parts, Semen Plantaginis 26 parts, Semen Sinapis Albae 15 parts, halberd Ye Wawei 30 parts, Fructus Perillae 14 parts, Lignum Aquilariae Resinatum 23 parts, Cortex Mori 32 parts, Fructus Rubi 20 parts, Fructus chebulae immaturus 30 parts, Semen Lepidii (Semen Descurainiae) 40 parts, Fructus Alpiniae Oxyphyllae 16 parts, Herba Thlaspis 33 parts, Radix Crepidis Ligneae 17 parts, dominoes Herba pteridii latiusculi 27 parts, Pericarpium Metaplexis 16 parts, Herba Kalimeridis 13 parts, the Radix Stemonae 3 parts, 25 parts, polished rod fine jade and Concretio Silicea Bambusae 36 parts.

When the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:

The first step, each for described pharmaceutical composition raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, is ground into powder subsequently, makes dried cream powder;

Second step, adds the dextrin of cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times, makes granule in the dried cream powder obtained, and in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described pharmaceutical composition is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described pharmaceutical composition raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

When the dosage form of described pharmaceutical composition is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described pharmaceutical composition raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85% ~ 95%, reflux 4 ~ 6 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 400 order ~ 500 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

The invention has the beneficial effects as follows: tool lung qi dispersing of the present invention heat clearing away, reason lung, the effect of relievining asthma and reducing phlegm, has the effect of the kidney invigorating, blood stasis dispelling diuretic and beneficial intensive culture gas concurrently, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

Detailed description of the invention

The present invention is with lung qi dispersing heat clearing away, reason lung, relieving asthma and reduce phlegm as primary treatment principle, treatment mycoplasma pneumoniae pneumonia, wherein, following raw medicinal material is comprised: Herba Lobeliae Sessilifoliae, Herba Caryopteridis Terniflorae, Fructus Aurantii, Fructus Arctii, the Radix Stemonae, Radix Platycodonis, Radix et Rhizoma Thalictri, Herba Houttuyniae, Radix Glycyrrhizae, Herba Ardisiae Japonicae, Pericarpium Metaplexis, Herba Kalimeridis, Rhizoma Zingiberis Recens, Fructus Elaeagni, Magnetitum, Herba Boschniakiae Rossicae, Succus Bambusae, Semen Plantaginis, Semen Sinapis Albae, halberd Ye Wawei, Concretio Silicea Bambusae, Fructus Perillae, Lignum Aquilariae Resinatum, Cortex Mori, Fructus Rubi, Fructus chebulae immaturus, Semen Lepidii (Semen Descurainiae), Fructus Alpiniae Oxyphyllae, Herba Thlaspis, Radix Crepidis Ligneae, polished rod fine jade and dominoes Herba pteridii latiusculi.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Herba Thlaspis: nature and flavor: herb: bitter, sweet, flat.Seed: pungent, bitter, tepor.Cure mainly: herb: heat-clearing and toxic substances removing, inducing diuresis and reducing edema, and middle appetizing.

Halberd Ye Wawei: source: fern Polypodiaceae halberd Ye Wawei Lepisorus waltonii (Ching) Ching, is used as medicine with spore.Nature and flavor: bitter, sweet, flat.Cure mainly: relieving stranguria by diuresis, eliminating heat from the lung.Cure mainly oedema due to nephritis, urinary tract infection, calculus of urethra, cough due to lung-heat, spitting of blood, bronchial asthma, the diseases such as pharyngolaryngitis.

Dominoes Herba pteridii latiusculi: nature and flavor: micro-bitter, sweet, flat.Nontoxic.Cure mainly: clearing away heat and promoting diuresis, relieving restlessness, lung heat clearing gas.Cure mainly and drench the drop difficulty in urination, heat syndrome cough, vexed.

Polished rod fine jade: another name: Herba Lycianthis Biflorae grass.Source: Labiatae Herba Lycianthis Biflorae grass platymiscium Eriophyton wallichii Benth Eriophyton wallichii Benth., with all herbal medicine.Nature and flavor: bitter, cold.Cure mainly: heat-clearing and toxic substances removing.For pneumonia, dysentery, pasture and water are poisoning, alimentary toxicosis.

Radix Crepidis Ligneae: source: " choosing of Yunnan Chinese herbal medicine ".Nature and flavor: " choosing of Yunnan Chinese herbal medicine ": " micro-sweetness and bitterness, cool." curing mainly: 1. " choosing of Yunnan Chinese herbal medicine ": " nourishing the lung to arrest cough, heat-clearing and toxic substances removing, helps digestion and regulates the flow of vital energy, lactogenic.Control bronchitis, pneumonia, carbuncle, infantile malnutrition, hypogalactia, conjunctivitis." 2. " Kunming conventional medical herbs among the people ": " tonify deficiency.Controlling body deadhead swoons unable."

Fructus chebulae immaturus: nature and flavor: bitter, micro-sweet, puckery, cool.Cure mainly: clearing away heat and promoting production of body fluid, liyan jiedu.For chronic pharyngolaryngitis, hoarseness, dry laryngopharynx.

Fructus Alpiniae Oxyphyllae: source: " must book on Chinese herbal medicine be joined ".Nature and flavor: pungent, temperature.Gui Jing: enter spleen, kidney channel.Cure mainly: warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Control cold air stomachache, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.

Fructus Rubi: source: Collective Notes to the Canon of Materia medica.Nature and flavor: sweet acid are flat.1. " not Lu ": " sweet in the mouth is flat, nontoxic." 2. " a thousand pieces of gold dietetic therapy ": " sweet in the mouth is pungent, flat." 3. " property of medicine opinion ": " slight fever, sweet in the mouth is pungent." 4. the Meng numerous: " sour in the mouth." return through: " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enters liver, kidney two warp." cure mainly: invigorating the liver and kidney, urine reducing, supporing yang, controlling nocturnal emission with astringent drugs, improving eyesight.

Lignum Aquilariae Resinatum: source: " not Lu ".Nature and flavor: arduous, temperature.1. " not Lu ": " tepor." 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter in the mouth, temperature, nontoxic." 3. " Japan hanako materia medica ": " acrid in the mouth, heat, nontoxic." 4. " detailed outline ": " is chewed fragrant and sweet person's property and is put down, and pungent person is hot in nature." return through: enter kidney, spleen, stomach warp.Cure mainly: sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI.Control QI rising in reverse order to pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.

Semen Sinapis Albae: source: Tang Materia Medica.Nature and flavor: pungent, temperature.Cure mainly: promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.Control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.

Herba Boschniakiae Rossicae: another name: Herba Cistanches.Nature and flavor: sweet, salty, temperature.Cure mainly: kidney invigorating and YANG supporting, loosening bowel to relieve constipation.For impotence due to deficiency of the kidney, chills and pain of the waist and kness, dryness of the intestine constipation.

Magnetitum: nature and flavor: salty, cold.Gui Jing: return liver, the heart, kidney channel.Cure mainly: suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.For having a dizzy spell, blurring of vision, Hiccough and deaf, palpitation with fear insomnia, asthma of suffering from a deficiency of the kidney.

Fructus Elaeagni: source: Collective Notes to the Canon of Materia medica.Nature and flavor: acid is wet are flat.1. " Huatuo's Zhongzang classic ": " sour and astringent." 2. horse bowl " cuisine canon ": " sweet in the mouth." 3. " detailed outline ": " acid, flat, nontoxic." cure mainly: control dysentery, quench one's thirst, breath with cough.1. Ma Wan " cuisine canon ": " tonification the five internal organs." 2. " vegetation is side just ": " heat clearing away and restlessness relieving, quenches one's thirst." " modern Practical Chinese medicinal ": " restrains, and antidiarrheal, controls dysentery." 4. " Fujian traditional herbal medicine ": " stops blooding, and treats dysentery." 5. Jinhua " conventional Chinese herbal folk proved recipe a collection of selected materials ": " astringing to arrest diarrhea, relieving cough and asthma.Control dyspepsia, hernia, breath with cough, metrorrhagia, osteomyelitis, hemorrhoid, lumbar strain."

Herba Kalimeridis: source: supplement to the Herbal.Nature and flavor: pungent are cool.1. " praise and help book on Chinese herbal medicine ": be " pungent, flat, nontoxic." 2. " beautiful Chinese catalpa medicine solution ": " bitter in the mouth is pungent, and gas is put down." 3. " occupying diet spectrum with breath ": " Gan Xin is cool." return through: 1. " detailed outline ": " enters positive bright blood system." 2. " jade seizes medicine solution ": " start with lunar lung, liver channel of foot-Jueyin." cure mainly: removing heat from blood, heat clearing away, dampness removing, removing toxic substances.Control haematemesis, epistaxis, dysentery, wound hemorrhage, malaria, jaundice, edema, stranguria with turbid discharge, pharyngalgia, sore throat, hemorrhoid, carbuncle, erysipelas, venom.

Pericarpium Metaplexis: source: " modern Practical Chinese medicinal ".Nature and flavor: " decoction pieces is newly joined ": " salty, flat." cure mainly: removing heat from the lung and dissipating phlegm.Control cough with copious phlegm, dyspnea and cough due to the lung-wind syndrome with phlegm, pertussis, frightened sick, measles without adequate eruption.1. " decoction pieces is newly joined ": " softening the hard mass, reduces phlegm, lung heat clearing.Control dyspnea and cough due to the lung-wind syndrome with phlegm, arresting convulsion epilepsy." 2. " medical material compilation of data ": " controls infantile measles." 3. Jiangxi " medical herbs handbook ": " controls dyspnea and cough due to the lung-wind syndrome with phlegm, bleeding due to trauma." 4. " Chinese herbal medicine is commonly used in Shanghai ": " reduces phlegm, and cough-relieving, relievings asthma, and controls cough with copious phlegm, asthma, pertussis, and measles is sent out not smooth thoroughly, fever and cough."

Herba Ardisiae Japonicae: nature and flavor: pungent is flat.Cure mainly: relieving cough and resolving phlegm, removing toxic substances of dispeling the wind, promoting blood circulation and stopping pain.For bronchitis, lobar pneumonia, infantile pneumonia, pulmonary tuberculosis, hepatitis, dysentery, acute nephritis, urinary tract infection, stimulates the menstrual flow, traumatic injury, bones and muscles pain due to rheumatism; Skin itching is controlled in external, dermatitis rhus.

Herba Houttuyniae: nature and flavor: pungent, is slightly cold.Gui Jing: return lung meridian.Cure mainly: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.

Radix et Rhizoma Thalictri: nature and flavor: bitter, cold.Cure mainly: heat clearing and damp drying, eliminating fire and detoxication.For enteritis, dysentery, jaundice, conjunctival congestion and swelling pain.

The Radix Stemonae: nature and flavor: sweet, bitter, tepor.Gui Jing: return lung meridian.Slightly poisonous.Cure mainly: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendal pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.

Fructus Arctii: nature and flavor: pungent, bitter, cold.Gui Jing: attach to the lung and stomach meridians.Cure mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.

Herba Caryopteridis Terniflorae: nature and flavor: pungent, temperature.Cure mainly: deliver cold expelling, lung qi dispersing cough-relieving, promoting blood flow to regulate menstruation.For cold cough, chronic bronchitis, pertussis, stimulates the menstrual flow, puerperal abdonimal pain; Knife injury is controlled in external, burn and scald, venom.

Herba Lobeliae Sessilifoliae: nature and flavor: pungent is flat.Slightly poisonous.Cure mainly: dispersing lung-QI and dissipating phlegm, heat-clearing and toxic substances removing, inducing diuresis to remove edema.For bronchitis, cirrhotic ascites, edema; Venom is controlled in external, and honeybee stings, carbuncle furuncle.

Fructus Aurantii: bitter, acrid, cold, returns spleen, stomach, liver, the heart three warp.Dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.1. " property of medicine opinion ": control rubella all over, dislike and itch, main hemorrhoidal hamorrhage haemorrhoids, stagnation of QI in chest and abdomen in flesh as numb bean, the swollen void of two sides of body, pass diaphragm is congested.2. " Japan hanako materia medica ": spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.Control regurgitation, cholera dysentery, helps digestion, and broken crux mass beside the umbilicus, five types of dysphagia, except wind improving eyesight and lung qi edema, sharp intestine and small intestine, skin is itched.Swollen can the processing of hemorrhoid is pressed.3. " Kaibao Bencao ": main air is itched paralysis, easing joint movement, consumptive disease is coughed, and back of the body arm is bored and listless, loosely stays knot, chest and diaphragm expectorant stagnant, and relieve oedema or abdominal distension through diuresis or purgation, full, the large hemorrhoidal hamorrhage of relieving distension, peace stomach, only wind bitterly.4. " pearl sac ": dispelling the stagnated QI, gas unfavorable in lung is let out.5. " medicine origin ": " curing mainly secret formula " cloud, broken hardness in the epigastrium painful abdominal mass, profit is gas in the heart, reduces phlegm, and 6. help digestion " detailed outline ": control tenesmus.

Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mending five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." herbal classic " is said: " main chest and hypochondrium as lancination, abdominal distention, borborygmus are faint, gas of throbbing with fear in terror "." Japan hanako materia medica " is said: " mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant for all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, broken lump in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat ".Modern pharmacological research shows, Radix Platycodonis has and eliminates the phlegm and antitussive effect; Hypoglycemic activity; Suppress gastric secretion and antiulcer action; Antiinflammatory action; Calmness, analgesia and refrigeration function.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian.Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Rhizoma Zingiberis Recens: pungent, sweet, warm.Attach to the lung and stomach meridians.Relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, warming stomach for dispelling cold, warming the lung to eliminate phlegm, preventing or arresting vomiting.

Fructus Perillae: nature and flavor: pungent, temperature.Gui Jing: return lung meridian.Cure mainly: sending down the abnormal ascending QI expectorant, relieving asthma, intestine moistening.QI rising in reverse order is stopped up, cough and asthma, dryness of the intestine constipation for expectorant.

Succus Bambusae: sweetness and bitterness, cold; Enter the heart, stomach warp.Clear away heart-fire the fire of lung stomach, has eliminating phlegm to moisturize, the effect of arresting convulsion.Be mainly used in controlling middle wind-phlegm fan, lung-heat expectorant is stopped up, infantile convulsion, epilepsy, high fever excessive thirst, restlessness during pregnancy, tetanus.Essentials of Matea Medica: " pathogenic wind expelling pathogenic fire reducing, moisturizes row expectorant, and nourish blood tonifying YIN, sharp key tomorrow.Control apoplexy locked mouth, the large heat of expectorant fan, puerperal tetanus is demented, and unhappiness is quenched one's thirst, spontaneous sweating due to deficientcy of blood." " book on Chinese herbal medicine is new again ": " clearing away heart-fire, fall liver-fire, reduce phlegm and quench the thirst, antipyretic relieving restlessness, controls toothache, bright eyes." fire of the lung stomach that clears away heart-fire has eliminating phlegm to moisturize, the effect of arresting convulsion.Be mainly used in controlling middle wind-phlegm fan, lung-heat expectorant is stopped up, infantile convulsion, epilepsy, high fever excessive thirst, restlessness during pregnancy, tetanus.Succus Bambusae sweet in the mouth delays, and can have large hot person except the deficiency of YIN, Great Cold, person sayed its merit also, non-with gas speech, good fortune with could, if say not so, people eats Radix Crotalariae szemoensis since the childhood to the old, can no one because of Radix Crotalariae szemoensis cold and ill, also, condition is false in the fire person of forming for the liquid of drop and Radix Crotalariae szemoensis, how to tremble with fear so very.

Concretio Silicea Bambusae: sweet, cold; Enter the heart, liver, lung meridian.Function clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.Phlegm-heat cough." Japan hanako materia medica ": " control middle wind-phlegm stop up, acute aphasia in silence, convulsive seizure induced by terror in children and epilepsy expectorant." " Kaibao Bencao ": " main infantile convulsion sky hangs, and relieving palpitation improving eyesight, goes all wind heat, treats incised wound hemostasis, nourishes the five internal organs." function clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.Phlegm-heat cough.Fungus Zhuhuang water decoction extract 2-3.1g/kg subcutaneous injection, has good analgesic activity to mice acetic acid zest pain.Fungus Zhuhuang polysaccharide SB1 and SB2, through pharmacology preliminary test, has certain curative effect to hepatitis, and can dramatically and extend blood plasma recalcification time, in blood coagulation tests, this medicine can extend clotting time, may extend relevant with recalcification time.

Cortex Mori: Gan Han, enters lung meridian.Expelling phlegm for arresting cough, lets out lung diuretic.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly damaging the spleen and stomach, five kinds of over strain, six types of severe debility disease, weakness and emaciation, metrorrhagia, pulse disappeared, tonify deficiency, QI invigorating.Leaf: main except cold and heat, perspires." " Mingyi Bielu ": " nontoxic.Master goes aqueous vapor in lung, only hemoptysis, and heat is thirsty, edema, and abdominal distention, sets out swollen, dredging water passages, goes in vain very little, can stitch gold wound." " Japan hanako materia medica ": " and temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards.Expectorant is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea." function eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.Cortex Mori decoct gavage rabbit, Cortex Mori water extract or n-butanol extract are to rat oral gavage or lumbar injection.All have diuresis, all there is increase urine volume and sodium, Zhongli's and chloride output.Isolate moranoline from Cortex Mori, and confirm that it has hypoglycemic activity.Cortex Mori water extraction has suppression to be used as to get thing to the swollen feet caused by Oral Administration in Rats or injection on Carrageenan and glucosan.

Semen Lepidii (Semen Descurainiae): pungent, bitter, cold; Return lung meridian, heart channel, Liver Channel, stomach warp, urinary bladder channel.Function eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma, inducing diuresis to remove edema, lets out by heresy.

Embodiment 1 granule

The manufacturing process of granule of the present invention is: get Herba Lobeliae Sessilifoliae 30g, Herba Caryopteridis Terniflorae 120g, Fructus Aurantii 160g, Fructus Arctii 220g, Radix Platycodonis 300g, Radix et Rhizoma Thalictri 420g, Herba Houttuyniae 330g, Radix Glycyrrhizae 150g, Herba Ardisiae Japonicae 340g, Rhizoma Zingiberis Recens 150g, Fructus Elaeagni 350g, Magnetitum 140g, Herba Boschniakiae Rossicae 300g, Succus Bambusae 200g, Semen Plantaginis 350g, Semen Sinapis Albae 120g, halberd Ye Wawei 280g, Fructus Perillae 150g, Lignum Aquilariae Resinatum 200g, Cortex Mori 350g, Fructus Rubi 160g, Fructus chebulae immaturus 200g, Semen Lepidii (Semen Descurainiae) 300g, Fructus Alpiniae Oxyphyllae 130g, Herba Thlaspis 320g, Radix Crepidis Ligneae 220g and dominoes Herba pteridii latiusculi 260g,

Embodiment 2 capsule

The manufacturing process of capsule of the present invention is: get Herba Lobeliae Sessilifoliae 40g, Herba Caryopteridis Terniflorae 160g, Fructus Aurantii 320g, Fructus Arctii 220g, Radix Platycodonis 140g, Radix et Rhizoma Thalictri 420g, Herba Houttuyniae 330g, Radix Glycyrrhizae 150g, Herba Ardisiae Japonicae 280g, Rhizoma Zingiberis Recens 170g, Fructus Elaeagni 350g, Magnetitum 130g, Herba Boschniakiae Rossicae 240g, Succus Bambusae 180g, Semen Plantaginis 260g, Semen Sinapis Albae 150g, halberd Ye Wawei 300g, Fructus Perillae 140g, Lignum Aquilariae Resinatum 230g, Cortex Mori 320g, Fructus Rubi 200g, Fructus chebulae immaturus 300g, Semen Lepidii (Semen Descurainiae) 400g, Fructus Alpiniae Oxyphyllae 160g, Herba Thlaspis 330g, Radix Crepidis Ligneae 170g and dominoes Herba pteridii latiusculi 270g,

The first step, is mixed in proportion each for described pharmaceutical composition raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 350 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.3:0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Embodiment 3 tablet

The manufacturing process of tablet of the present invention is: get Herba Lobeliae Sessilifoliae 40g, Herba Caryopteridis Terniflorae 160g, Fructus Aurantii 320g, Fructus Arctii 220g, Radix Platycodonis 140g, Radix et Rhizoma Thalictri 420g, Herba Houttuyniae 330g, Radix Glycyrrhizae 150g, Herba Ardisiae Japonicae 280g, Rhizoma Zingiberis Recens 170g, Fructus Elaeagni 350g, Magnetitum 130g, Herba Boschniakiae Rossicae 240g, Succus Bambusae 180g, Semen Plantaginis 260g, Semen Sinapis Albae 150g, halberd Ye Wawei 300g, Fructus Perillae 140g, Lignum Aquilariae Resinatum 230g, Cortex Mori 320g, Fructus Rubi 200g, Fructus chebulae immaturus 300g, Semen Lepidii (Semen Descurainiae) 400g, Fructus Alpiniae Oxyphyllae 160g, Herba Thlaspis 330g, Radix Crepidis Ligneae 170g, dominoes Herba pteridii latiusculi 270g, Pericarpium Metaplexis 160g, Herba Kalimeridis 130g, Radix Stemonae 30g, polished rod fine jade 250g and Concretio Silicea Bambusae 360g,

The first step, is mixed in proportion each for described pharmaceutical composition raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 90%, reflux 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 92% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 3 hours, pulverize, sieve, obtain 450 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.15 times, 0.3 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.04 times of magnesium stearate, granulate, tabletting, makes.

Acute toxicity test: application NIH mice 40, S recovery from illness F level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 3 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Pharmaceutical composition clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage pharmaceutical composition of the present invention is 745 times of quantity.Therefore pharmaceutical composition acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: the granule of the embodiment of the present invention 1 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical composition of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical composition of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Cumulative toxicity test is reported: test method: select 20 healthy mices, female, each 10 of hero, with the capsule of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m0g/k0gBW (five dosage is 500,750,1100,1700,2500m0g/k0gBW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/100gBW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.

Clinical data:

Case selection: the 200 routine mycoplasma pneumoniae pneumonia patients selecting in October, 2013 to 2014 year outpatient service in October or be in hospital, age 3-12 year, average (5.67 ± 3.77) year, before being in hospital the course of disease be (7.10 ± 2.88) year; Rabat (or lung CT) shows two lung stigma lamellar 7 examples, side lung field is large lamellar shade 157 example, side lung field is large lamellar shade companion's pleural thickening or a small amount of hydrothorax 36 example, Granules in Treating group, capsule treatment group, tablet in treatment group and matched group are divided at random to 200 routine patients, each experimental group 50 people, above-mentioned Gender, the age, be in hospital before the course of disease, rabat (or lung CT) order of severity etc. after statistical analysis, the equal not statistically significant of difference, has comparability.

Diagnostic criteria:

Western medicine diagnose standard: with reference to " all good fortune Chinese bush cherry practical paidonosologies " ^[3]7th edition formulation: heating, pattern of fever is indefinite, long period paroxysmal cough or productive cough, and infant can have dyspnea etc.; Leukocyte counts and classification normally or are slightly increased mostly; Pulmonary haves a medical check-up most without obvious positive sign, and minority is heard and in moist rale; Blood mycoplasma antibody positive, chest film inspection has obvious change, and comparatively sign is remarkable.

Standards of Chinese Medical Syndrome Differentiation: compile " Pediatrics of Chinese Medicine (cuing open for 7 years) " by the hero of biography with reference to Wang ^[4]interior pneumonia asthma is coughed, fever and irritability, and cough is breathed, flaring of nares out of breath, wheezing sound in the throat, and flushed complexion is thirsty, distending pain uncomfortable in chest, general leaf sputum, red tongue, yellow and greasy fur, stringy and rolling pulse.

Therapeutic Method:

In medication therapy groups:

Granules in Treating group: use the embodiment of the present invention 1 to prepare granule, every day 3 times, once a bag, every bag of 6g every 7 days is 1 course for the treatment of;

Capsule treatment group: take the embodiment of the present invention 2 prepare capsule, every day 3 times, one time 1, within every 7 days, be a course for the treatment of;

Tablet in treatment group: use the embodiment of the present invention 3 prepare tablet, every day 3 times, one time 1, within every 7 days, be a course for the treatment of.

Matched group: take Erythromycin Ethylsuccinate Tablets, every day 2 times, a 800mg every 7 days is a course for the treatment of.

The standard of curative effect evaluation:

Comprehensive therapeutic effect evaluation criteria to be coughed efficacy assessment standard and " new Chinese medicine guideline of clinical investigations " formulation with reference to " Chinese medical disease Standardization of diagnosis and curative effect TCM Pediatrics disease Standardization of diagnosis and curative effect " interior pneumonia asthma that State Administration of Traditional Chinese Medicine 1994 issues:

Recovery from illness: 1. breathe and recover normal (frequency of respiration per minute is in range of normal value); 2. auscultation of lung tremble sound disappear; 3. X ray examination pneumonia shade absorbs (two lung fields are clear); 4. Respirovirus detects negative; 5. the minimizing of primary symptom integration is greater than 90%.Effective: 1. to breathe and recover normal (frequency of respiration per minute is in range of normal value); 2. auscultation of lung tremble sound disappear; 3. X ray examination pneumonia shade basic absorption (two lung fields are without point lamellar confusing shadows); 4. Respirovirus detects negative; 5. primary symptom integration reduces < 90%, is greater than 67%.Effective: 1. infant breathes basic recovery normal (frequency of respiration per minute is no more than corresponding age Upper Limit of Normal Value 10 times); 2. auscultation of lung tremble sound reduce; 3. X ray examination pulmonary shadow part absorbs; 4. Respirovirus detects negative; 5. primary symptom integration reduces < 67%, is greater than 33%.Invalid: shape sign is without significant change or increase the weight of, primary symptom integration reduces < 33%.Note: disease integration reduces front integration × 100% of percentage rate=(treat front integration one and treat rear integration)/treatment

Primary symptom and time disease:

Primary symptom: heat, cough, expectorant heap soil or fertilizer over and around the roots, tachypnea, flaring of nares, asthma, auscultation of lung, the full breast sheet of X line;

Secondary disease: cold, dark purple, color, god, perspiration, thirsty, appetite, Nausea and vomiting, stool, urine, extremity, picture of the tongue, fingerprint.

Primary and secondary disease scale score standard:

Primary symptom:

Heating: < 37.2 DEG C 0 point; 37.3 ~ 38.4 DEG C 2 points; 38.5 ~ 39.4 DEG C 4 points; >=39.5 DEG C 6 points.

Cough: without cough 0 point; Even work, often coughs monophone 2 points; Battle array is done, and often coughs several sound 4 points; Hacking cough, often coughs many sound, causes vomiting, affects work and rest 6 points.

Expectorant is stopped up: without 0 point, expectorant; Expectorant sound is had, few 2 points, expectorant time in larynx; In larynx, expectorant is neighed, yellow 4 points of expectorant; In larynx, expectorant is shouted, many 6 points of expectorant Huang amount.

Tachypnea: breathe steadily, number of times in corresponding age range of normal value 0 point; Exceed corresponding age Upper Limit of Normal Value and be less than or equal to 10 beats/min, without flaring of nares, three depressions sign 2 points; Exceed corresponding age Upper Limit of Normal Value 11 ~ 20 beats/min, and/or be interrupted and breathe heavily and suppress, flaring of nares, three depressions sign 4 points; Exceed corresponding age Upper Limit of Normal Value and be more than or equal to 21 beats/min, and/or continue to breathe heavily and suppress, flaring of nares, three depressions sign 6 points.

Asthma, cyanosis: nothing, 0 point; Slightly breathe heavily, 2 points; Asthma is obvious, without cyanosis 4 points; Significantly, cyanosis of the lips and nails, needs oxygen uptake 6 points in asthma.

Auscultation of lung: clear 0 point of respiratory murmur; Respiratory murmur reduces, coarse, or hear and in wet sound 2 points of trembling; In the pulmonary of side, thin wet sound and/or the sound 4 points of stridulating a little of trembling; In the pulmonary of both sides, thin wet sound and/or the sound 6 points of significantly stridulating of trembling.

The full rabat of X line: clear 0 point of two lung fields; Enhanced lung markings, increase thick, disorderly 2 points; Point lamellar confusing shadows, to be confined within 2 leaves 4 points; Point lamellar confusing shadows, 3 leaves and above 6 points.

With primary symptom integration for foundation, draft slight: 8 ~ 16 points, moderate: 17 ~ 26 points, severe: 27 ~ 36 points.

Secondary disease:

Aversion to cold: 0 point of nothing; 1 point of aversion to wind; 2 points of aversion to cold.

Cyanosis: 0 point of nothing; 1 point of lip dark purple; 2 points of lips, refer to cyanosis.

Complexion: 0 point normal; 1 point of few China; 2 points of flushing, in vain light.

Spirit: 0 point normal; 1 point of agitation; 2 points of spiritlessness and weakness.

Perspire: 0 point normal; 1 point of slight perspiration; 2 points of hyperhidrosis wet clothing.

Thirsty: 0 point of nothing; 1 point slightly thirsty; 2 points of thirsty polydipsia.

Appetite: 0 point normal; 1 point of poor appetite; 2 points of foods of not pursuing progress.

Nausea and vomiting: 0 point of nothing; Feel sick for 1 point; 2 points of nausea and vomiting.

Stool: 0 point normal; 1 point of dry stool; 2 points of stool are rare.

Urine: 0 point normal; 1 point of Huang is few.

Extremity: 0 point normal; Owe temperature for 1 point; 2 points cool.

Body of the tongue: 0 point normal; 1 sub-prime is red; 2 sub-primes are light red.

Tongue fur: 0 point in vain thin; 1 point of BOHUANG; 2 points of Huangs are greasy; 3 potted flower strippings.

Pulse condition (fingerprint): 0 point floating tight (red); 1 point of floating number (purple); 2 points of sliding numbers (purple stagnant); 3 points thin (light).

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy mycoplasma pneumoniae pneumonia of the present invention, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy mycoplasma pneumoniae pneumonia of the present invention, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	Number of cases	Recovery from illness number	Effective number	Significant figure	Invalid number	Effective percentage (%)
							Granules in Treating group	50	42	4	2	2	96％
Capsule treatment group	50	45	3	1	1	98％
							Tablet in treatment group	50	48	2	0	0	100％
Matched group	50	11	20	12	7	86％

Table 2 Four composition is fully recovered after not treating 4 courses for the treatment of, effective and efficiently individual quantity time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of	4th course for the treatment of
						Granules in Treating group	48	10（20.8％）	11（22.9％）	13（27.1％）	14（29.2％）
Capsule treatment group	49	10（20.4％）	12（24.5％）	13（26.5％）	14（28.6％）
						Tablet in treatment group	50	11（22％）	12（24％）	13（26％）	14（28％）
Matched group	43	1（2.3％）	3（7％）	5（11.6％）	34（79.1％）

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Simultaneously to 147 examples for the treatment of group recovery from illness, effective and efficiently individual quantity and matched group recovery from illness, effective and effective 43 routine follow-up of patients 1 year half, result is added up, in Granules in Treating group 48 example, recovery from illness and effective 46 examples are all without recurrence, 1 case relapsed in effective 2 examples, and relapse rate is 2.1%; In capsule treatment group 49 example, recovery from illness and effective 48 examples are all without recurrence, 1 case relapsed in effective 1 example, and relapse rate is 2.0%; In tablet in treatment group 50 example recovery from illness and effective 50 in all without recur, relapse rate is 0%; In matched group recovery from illness, effective and efficiently individual quantity 43 example, all without recurrence in 11 examples of fully recovering, in effective 31 routine patients, recur 7 examples, recur 9 routine in effective 12 routine patients, relapse rate 37.2%; Above-mentioned recurrence refer to patient outcomes reach effective or effectively after, in 1 year half of following up a case by regular visits to, obviously there is the symptom before treatment.

Model case: Liu, male, 6 years old, Cangzhou, Hebei institute of traditional Chinese medicine, because having shiver with cold, heating, weak, the sticky expectorant of headache, purulent sputum to go to a doctor, nasopharynx part and conjunctival congestion on inspection, edema, have cervical lymph node enlargement, erythra, auscultation of lung can have fine rales, x line rabat, for lung marking increases, many patches confusing shadows, pulmonary parenchyma has polymorphic infiltration shape, common with inferior lobe, Serological testing: detect mycoplasma pneumoniae antigen, be diagnosed as mycoplasma pneumonia.Take the granule of pharmaceutical composition embodiment 1 of the present invention, every day 3 times, once a bag, every bag of 6g, medication is cured a course for the treatment of substantially, continues medication two weeks and cures, follow up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the pharmaceutical composition of mycoplasma pneumoniae pneumonia for one kind, it is characterized in that, comprise following raw medicinal material: Herba Lobeliae Sessilifoliae, Herba Caryopteridis Terniflorae, Fructus Aurantii, Fructus Arctii, Radix Platycodonis, Radix et Rhizoma Thalictri, Herba Houttuyniae, Radix Glycyrrhizae, Herba Ardisiae Japonicae, Rhizoma Zingiberis Recens, Fructus Elaeagni, Magnetitum, Herba Boschniakiae Rossicae, Succus Bambusae, Semen Plantaginis, Semen Sinapis Albae, halberd Ye Wawei, Fructus Perillae, Lignum Aquilariae Resinatum, Cortex Mori, Fructus Rubi, Fructus chebulae immaturus, Semen Lepidii (Semen Descurainiae), Fructus Alpiniae Oxyphyllae, Herba Thlaspis, Radix Crepidis Ligneae and dominoes Herba pteridii latiusculi.

2. the pharmaceutical composition for the treatment of mycoplasma pneumoniae pneumonia according to claim 1, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 3 ~ 5 parts, Herba Caryopteridis Terniflorae 10 ~ 20 parts, Fructus Aurantii 15 ~ 35 parts, Fructus Arctii 12 ~ 22 parts, Radix Platycodonis 11 ~ 31 parts, Radix et Rhizoma Thalictri 15 ~ 45 parts, Herba Houttuyniae 14 ~ 34 parts, 10 ~ 20 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 12 ~ 36 parts, 10 ~ 20 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 12 ~ 38 parts, Magnetitum 10 ~ 20 parts, Herba Boschniakiae Rossicae 11 ~ 32 parts, Succus Bambusae 10 ~ 30 parts, Semen Plantaginis 15 ~ 35 parts, Semen Sinapis Albae 10 ~ 20 parts, halberd Ye Wawei 12 ~ 32 parts, Fructus Perillae 10 ~ 20 parts, Lignum Aquilariae Resinatum 14 ~ 28 parts, Cortex Mori 15 ~ 35 parts, Fructus Rubi 10 ~ 22 parts, Fructus chebulae immaturus 15 ~ 30 parts, Semen Lepidii (Semen Descurainiae) 10 ~ 40 parts, Fructus Alpiniae Oxyphyllae 10 ~ 20 parts, Herba Thlaspis 10 ~ 35 parts, Radix Crepidis Ligneae 10 ~ 22 parts and dominoes Herba pteridii latiusculi 10 ~ 30 parts.

3. the pharmaceutical composition for the treatment of mycoplasma pneumoniae pneumonia according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 3 parts, Herba Caryopteridis Terniflorae 12 parts, Fructus Aurantii 16 parts, Fructus Arctii 22 parts, Radix Platycodonis 30 parts, Radix et Rhizoma Thalictri 42 parts, Herba Houttuyniae 33 parts, 15 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 34 parts, 15 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 35 parts, Magnetitum 14 parts, Herba Boschniakiae Rossicae 30 parts, Succus Bambusae 20 parts, Semen Plantaginis 35 parts, Semen Sinapis Albae 12 parts, halberd Ye Wawei 28 parts, Fructus Perillae 15 parts, Lignum Aquilariae Resinatum 20 parts, Cortex Mori 35 parts, Fructus Rubi 16 parts, Fructus chebulae immaturus 20 parts, Semen Lepidii (Semen Descurainiae) 30 parts, Fructus Alpiniae Oxyphyllae 13 parts, Herba Thlaspis 32 parts, Radix Crepidis Ligneae 22 parts and dominoes Herba pteridii latiusculi 26 parts.

4. the pharmaceutical composition of the treatment mycoplasma pneumoniae pneumonia according to any one of claim 1-3, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 4 parts, Herba Caryopteridis Terniflorae 16 parts, Fructus Aurantii 32 parts, Fructus Arctii 22 parts, Radix Platycodonis 14 parts, Radix et Rhizoma Thalictri 42 parts, Herba Houttuyniae 33 parts, 15 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 28 parts, 17 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 35 parts, Magnetitum 13 parts, Herba Boschniakiae Rossicae 24 parts, Succus Bambusae 18 parts, Semen Plantaginis 26 parts, Semen Sinapis Albae 15 parts, halberd Ye Wawei 30 parts, Fructus Perillae 14 parts, Lignum Aquilariae Resinatum 23 parts, Cortex Mori 32 parts, Fructus Rubi 20 parts, Fructus chebulae immaturus 30 parts, Semen Lepidii (Semen Descurainiae) 40 parts, Fructus Alpiniae Oxyphyllae 16 parts, Herba Thlaspis 33 parts, Radix Crepidis Ligneae 17 parts and dominoes Herba pteridii latiusculi 27 parts.

5. the pharmaceutical composition of the treatment mycoplasma pneumoniae pneumonia according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, each raw medicinal material also comprises: Pericarpium Metaplexis, Herba Kalimeridis, the Radix Stemonae, polished rod fine jade and Concretio Silicea Bambusae.

6. the pharmaceutical composition of the treatment mycoplasma pneumoniae pneumonia according to any one of claim 1-5, is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 3 ~ 5 parts, Herba Caryopteridis Terniflorae 10 ~ 20 parts, Fructus Aurantii 15 ~ 35 parts, Fructus Arctii 12 ~ 22 parts, Radix Platycodonis 11 ~ 31 parts, Radix et Rhizoma Thalictri 15 ~ 45 parts, Herba Houttuyniae 14 ~ 34 parts, 10 ~ 20 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 12 ~ 36 parts, 10 ~ 20 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 12 ~ 38 parts, Magnetitum 10 ~ 20 parts, Herba Boschniakiae Rossicae 11 ~ 32 parts, Succus Bambusae 10 ~ 30 parts, Semen Plantaginis 15 ~ 35 parts, Semen Sinapis Albae 10 ~ 20 parts, halberd Ye Wawei 12 ~ 32 parts, Fructus Perillae 10 ~ 20 parts, Lignum Aquilariae Resinatum 14 ~ 28 parts, Cortex Mori 15 ~ 35 parts, Fructus Rubi 10 ~ 22 parts, Fructus chebulae immaturus 15 ~ 30 parts, Semen Lepidii (Semen Descurainiae) 10 ~ 40 parts, Fructus Alpiniae Oxyphyllae 10 ~ 20 parts, Herba Thlaspis 10 ~ 35 parts, Radix Crepidis Ligneae 10 ~ 22 parts, dominoes Herba pteridii latiusculi 10 ~ 30 parts, Pericarpium Metaplexis 13 ~ 26 parts, Herba Kalimeridis 11 ~ 21 parts, the Radix Stemonae 3 ~ 4 parts, 14 ~ 28 parts, polished rod fine jade and Concretio Silicea Bambusae 10 ~ 40 parts.

7. the pharmaceutical composition of the treatment mycoplasma pneumoniae pneumonia according to any one of claim 1-6, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Herba Lobeliae Sessilifoliae 4 parts, Herba Caryopteridis Terniflorae 16 parts, Fructus Aurantii 32 parts, Fructus Arctii 22 parts, Radix Platycodonis 14 parts, Radix et Rhizoma Thalictri 42 parts, Herba Houttuyniae 33 parts, 15 parts, Radix Glycyrrhizae, Herba Ardisiae Japonicae 28 parts, 17 parts, Rhizoma Zingiberis Recens, Fructus Elaeagni 35 parts, Magnetitum 13 parts, Herba Boschniakiae Rossicae 24 parts, Succus Bambusae 18 parts, Semen Plantaginis 26 parts, Semen Sinapis Albae 15 parts, halberd Ye Wawei 30 parts, Fructus Perillae 14 parts, Lignum Aquilariae Resinatum 23 parts, Cortex Mori 32 parts, Fructus Rubi 20 parts, Fructus chebulae immaturus 30 parts, Semen Lepidii (Semen Descurainiae) 40 parts, Fructus Alpiniae Oxyphyllae 16 parts, Herba Thlaspis 33 parts, Radix Crepidis Ligneae 17 parts, dominoes Herba pteridii latiusculi 27 parts, Pericarpium Metaplexis 16 parts, Herba Kalimeridis 13 parts, the Radix Stemonae 3 parts, 25 parts, polished rod fine jade and Concretio Silicea Bambusae 36 parts.

8. the preparation method of the pharmaceutical composition of the treatment mycoplasma pneumoniae pneumonia according to any one of claim 1-7, is characterized in that, when the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:

9. the preparation method of the pharmaceutical composition of the treatment mycoplasma pneumoniae pneumonia according to any one of claim 1-7, is characterized in that, when the dosage form of described pharmaceutical composition is capsule, its preparation method comprises the following steps:

10. the preparation method of the pharmaceutical composition of the treatment mycoplasma pneumoniae pneumonia according to any one of claim 1-7, is characterized in that, when the dosage form of described pharmaceutical composition is tablet, its preparation method comprises the following steps: