CN104940696A - Medicine for treating liver meridian damp-heat type infantile enuresis and preparation method thereof - Google Patents

Abstract

The invention discloses medicine for treating liver meridian damp-heat type infantile enuresis. The medicine comprises the crude medicinal materials of glossy privet fruit, szechwan Chinaberry fruit, trillium tschonoskii maxim, lithospermum, tall rattlesnake plantain herb, hippuris vulgaris, citron, oroxylum indicum, bergamot, radix isatidis, dark plum, herba inulae, hedyotis diffusa, stephania sinica diels, dayflower, evodia lepta, liquorice, calamint, gnaphalium tranzschelii, Chinese aralis roots, saxifraga stolonifera, adina pilulifera, ash bark, cicada slough, corn, spina date seeds, ashycoloured ironweed herb, mimosa pudica, polemonium caeruleum and semen boitae. The medicine has the effects of soothing the liver and the gallbladder, cooling and reducing internal heat, clearing dampness and eliminating heat, and cultivating qi and soothing the nerves, and mainly treats liver meridian damp-heat type infantile enuresis. The medicine treats infantile enuresis internally and externally and treats both symptoms and root causes, the pure natural Chinese herbal medicinal materials are adopted, attention to the holism concept is paid, targeting is high, the curative effect is remarkable, effect taking is quick, adverse reactions are fewer, whole immunity can be improved, the illness state is controlled in time, and complications are reduced.

Description

A kind ofly treat medicine of ascites of liver meridian damp-heat type bed-wetting and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind ofly treating medicine of ascites of liver meridian damp-heat type bed-wetting and preparation method thereof.

Background technology

Enuresis (enuresis), also known as nonorganic enuresis or Functional nocturnal enuresis, means that child does not still independently urinate after 5 years old and urinates wet trousers or bed usually, but without obvious organic diseases because of.Enuresis has two kinds of methods of classifying.The first classification be according to the enuresis occur time and determine, (nighttime sleep and afternoon nap is comprised) when child enuresis occurs in sleep, but can control daytime to urinate, and bladder function is normal, then be called the enuresis nocturna of single symptom, and the enuresis is had when children's regains consciousness daytime, but the pathological changes of impassivity system such as spina bifida, spinal injury etc., be then called the daytime enuresis.The second classification method is referred to as constitutional and secondary enuresis, and so-called constitutional refers to that children's has the enuresis from little to time medical always, and Secondary cases refers to that children's once stopped the enuresis at least 6 months, again the enuresis occurs later.

It is reported, primary enuresis is in the great majority, wherein especially the most common with enuresis nocturna, common with boy, enuresis nocturna person about has half to wet the bed every night, even every night the enuresis 2 ~ 3 times, often enuresis increased frequency after excessive daytime activity, excitement, fatigue or physical disease, the enuresis is more rare in the daytime.Enuresis infant usually accompanies fright at night, sleep-walking, many dynamic or other behavior disorders.

Enuresis is not a kind of disease, but a symptom caused by many reasons, its factor occurred comprises heredity, psychology and society factor, sleep state, bladder function capacity etc.

Pathogenesis:

1. inherited genetic factors enuresis child often has family history, the probability of the monodidymus co-morbid of enzygotic twins higher than dizygotic twins person, parents have enuresis person, in offspring, finding that there is enuresis, person reaches 77%; The 1 people person that has enuresis in father and mother, it is 44% that children suffer from enuresis.But, only there is daytime the child of enuresis to seem to have nothing to do with heredity, and all have the child of the enuresis at those daytimes and night, have obvious male's household heredity factors.Shaffer etc. (1984) find that Positive family history is all very common in primary enuresis and secondary enuresis, illustrate that inherited genetic factors plays a part certain.Some researchs of nearest Denmark confirm that the dominant gene of the enuresis is that this genetics research being found to be enuresis provides further evidence on No. 13 chromosome.

2. the epidemiological study of premature labor enuresis confirms, premature labor is child's the most significant high risk factor of the enuresis in the daytime.These premature infants, except having the enuresis, also often with other problem, as attention deficit hyperactivity disorder, have scholar to point out this may be the cause of spared nerve injury.

3. the father and mother of enuresis child of can not awakening from sleep usually report their children have sleep deeply with the phenomenon being difficult to wake up.In fact enuresis nocturna and Depth of sleep have nothing to do, and the enuresis can occur in sleep any stage, and its subject matter is when filling of bladder, and infant can not awakening from sleep.Whether oneself to wake up night the degree that the phenomenon of urinating with or without being reluctant to get up after urinating, whether other people wake up or oneself wake up and wake up in lavatory and determining awakens according to infant clinically.

4. the stressors that psychology and society factor is strong as the bad experience (parental separation, death, child are separated suddenly with father and mother, are due to illness in hospital or contingency) in child's period, just admission be not suitable with new academic environment etc. all can cause child the critical period controlling to urinate because of mental tension the enuresis.Enuresis child also often has more behavior problem and emotional problem, and as how dynamic, twitch, unsocial, shy, temper is eccentric, and it is reported, in enuresis child, about 10% has attention deficit hyperactivity disorder, and boy is more than girl.

5. the bladder capacity of bladder capacity little enuresis child is little compared with the child of the same age without the enuresis.Each urine volume of normal children is about 10ml/kg, and its urine volume of the children's of enuresis does not reach the capacity of due bladder.In general, average each urine volume of these children is less than 10ml/kg, and on frequent micturition on daytime (> 7 times), have urgent micturition phenomenon, evening, enuresis number of times can be more than 1 time, and urine volume can be more or less.

6. constipation enuresis child often has the problem of constipation, the child of the enuresis in the daytime that common is especially, this is because during constipation, sensation is neural consumingly for the excrement block in ampulla of rectum portion, affect brain and causes the enuresis to the perception filled of bladder.

7. the shortage vasopressin of vasopressin raised at night, made child's hypourocrinia in sleep.Have some only enuresis nocturna child because vasopressin lack normal circadian secretion, cause nocturnal urine volume to increase, exceed the capacity of bladder, cause the enuresis.Infant is the enuresis soon after being everlasting and falling asleep, the time generation enuresis of initial 1/3 of generally sleeping at night, and urine stain is large, urinates as the head of a family wakes infant up, then can without enuresis phenomenon.

Enuresis should emphasize comprehensive treatment, and its content comprises:

1. Psychological support and health education 2. urinary function train 3. behavior therapy (1) to put schedule (2) strengthening (3) progressively to postpone the use of nocturnal awakenings time (4) alarm.4. Drug therapy (1) imipramine: this medicine can reduce enuresis nocturna, main mechanism, for alleviating Depth of sleep, makes enuresis child can aware the overflow of bladder.Imipramine unsuitable for children application in less than 6 years old, before within more than 6 years old, child generally sleeps at night, 1h is oral, and dosage range is each 1.0 ~ 1.5mg/kg.Imipramine untoward reaction is giddy, constipation, cardiopalmus, xerostomia and dim eyesight.As overdose, can cause untoward reaction, symptom is tic, ventricular tachycardia and loss of consciousness.This medicine should not be applied in the enuresis child of those home environment instability.In medication process, when the enuresis correct after, medicine should maintain 6 months, then gradually decrement to drug withdrawal.(2) acetic acid removes amine vassopressin: this is a kind of neurohypophyseal hormone of synthesis, be mainly used in the enuresis child because vasopressin lacks, the bladder capacity of these infants is normal, often have night and (or) daytime the enuresis, nocturnal urine volume increases, and urina sanguinis proportion is low, first amount is per os hora somni 0.2mg, as curative effect significantly can not increase to 0.4mg, stopped using after using 3 months continuously at least 1 week, to assess the need of continual cure.Treatments period need be restricted water supply, generally water restriction amount in 1h to 8h after taking medicine before taking medicine.This medicine can cause headache to minority child, feel sick, have a stomachache or epistaxis.

Traditional Chinese medical science motherland medical science thinks that enuresis system deficiency of kidney-QI, bladder can not restrict the event of urine.Syndrome-classification: deficiency of kidney-QI: the middle enuresis of sleeping, urine volume is many, and urine color is clear, sleep soundly, not easily wakes, pale white complexion, lassitude, coldness of the body with chills.Pale tongue, tongue is white, and deep-slow pulse is unable.Deficiency of both the splenic and pulmonary QI: the middle enuresis of sleeping, frequent micturition and measure many, lusterless complexion, spiritlessness and weakness, inappetence, large loose stool is thin.Tongue is partially light, and moderate pulse is thin.Dampness-heat of the liver: the middle enuresis of sleeping, frequent micturition amount is few, irascible temperament, feverish sensation in the palms and soles, red lip and doing.Red tongue, yellow fur, stringy and rolling pulse.

Because doctor trained in Western medicine one side medicine is cured the symptoms, not the disease, fundamentally cannot change the basic disease of bed-wetting, moreover the toxic and side effects of Western medicine is larger, therefore, has bad precipitation toxin impact for children and youth.Compared with doctor trained in Western medicine, Chinese medicine has better effect.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of medicine, has soothing liver-QI benefit gallbladder, refrigerantly to reduce internal heat, damp eliminating heat extraction, effect of calming the nerves of fostering the spirit of nobility, and cures mainly ascites of liver meridian damp-heat type bed-wetting.The present invention treats bed-wetting, internal and external application, effects a permanent cure while controlling table, and adopt natural Chinese medicines material, effective, curative effect is fast, do not recur, there is no toxic and side effects, great attention to whole idea, targeting is stronger, evident in efficacy, untoward reaction is less, can improve overall immunity simultaneously, timely symptom management, reduces the generation etc. of complication.

For solving the problems of the technologies described above, the invention provides a kind of medicine for the treatment of ascites of liver meridian damp-heat type bed-wetting, comprise following raw medicinal material: Fructus Ligustri Lucidi, Fructus Toosendan, Rhizoma Trillii Tschonoskii, Radix Arnebiae (Radix Lithospermi), Herba Goodyerae Procerae, Herba Hippuridis Vulgaris, Fructus Citri, Semen Oroxyli, Fructus Citri Sarcodactylis, Radix Isatidis, Fructus Mume, Herba Inulae, Herba Hedyotidis Diffusae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Commelinae, Foliumet Ramulus Evodiae, Radix Glycyrrhizae, Herba Clinopodii Polycephali, Herba Gnaphalii uliginosi, Radix araliae chinensis (Cortex Araliae Chinensis), Herba Saxifragae, Ramulus et Folium Adinae Piluliferae, Cortex Fraxini, Periostracum Cicadae, Semen setariae, Semen Ziziphi Spinosae, Herba Vernoniae Cinereae, Herba Mimosae Pudicae, Radix Polemonii Liniflori and Semen Platycladi.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Ligustri Lucidi 10-15 weight portion, Fructus Toosendan 2-4 weight portion, Rhizoma Trillii Tschonoskii 12-23 weight portion, Radix Arnebiae (Radix Lithospermi) 10-20 weight portion, Herba Goodyerae Procerae 7-13 weight portion, Herba Hippuridis Vulgaris 8-15 weight portion, Fructus Citri 10-15 weight portion, Semen Oroxyli 5-10 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Radix Isatidis 15-25 weight portion, Fructus Mume 7-12 weight portion, Herba Inulae 1-3 weight portion, Herba Hedyotidis Diffusae 10-20 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 15-20 weight portion, Herba Commelinae 7-13 weight portion, Foliumet Ramulus Evodiae 10-20 weight portion, Radix Glycyrrhizae 15-25 weight portion, Herba Clinopodii Polycephali 6-12 weight portion, Herba Gnaphalii uliginosi 10-20 weight portion, Radix araliae chinensis (Cortex Araliae Chinensis) 2-4 weight portion, Herba Saxifragae 1-3 weight portion, Ramulus et Folium Adinae Piluliferae 2-5 weight portion, Cortex Fraxini 6-13 weight portion, Periostracum Cicadae 8-14 weight portion, Semen setariae 6-13 weight portion, Semen Ziziphi Spinosae 10-15 weight portion, Herba Vernoniae Cinereae 15-20 weight portion, Herba Mimosae Pudicae 3-5 weight portion, Radix Polemonii Liniflori 10-20 weight portion and Semen Platycladi 8-15 weight portion.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Ligustri Lucidi 10-15 weight portion, Fructus Toosendan 2-4 weight portion, Rhizoma Trillii Tschonoskii 16-23 weight portion, Radix Arnebiae (Radix Lithospermi) 10-16 weight portion, Herba Goodyerae Procerae 7-13 weight portion, Herba Hippuridis Vulgaris 8-15 weight portion, Fructus Citri 10-15 weight portion, Semen Oroxyli 5-10 weight portion, Fructus Citri Sarcodactylis 15-20 weight portion, Radix Isatidis 15-20 weight portion, Fructus Mume 7-12 weight portion, Herba Inulae 1-3 weight portion, Herba Hedyotidis Diffusae 15-20 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 15-20 weight portion, Herba Commelinae 7-13 weight portion, Foliumet Ramulus Evodiae 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, Herba Clinopodii Polycephali 6-12 weight portion, Herba Gnaphalii uliginosi 15-20 weight portion, Radix araliae chinensis (Cortex Araliae Chinensis) 2-4 weight portion, Herba Saxifragae 1-3 weight portion, Ramulus et Folium Adinae Piluliferae 2-5 weight portion, Cortex Fraxini 6-13 weight portion, Periostracum Cicadae 8-14 weight portion, Semen setariae 6-13 weight portion, Semen Ziziphi Spinosae 10-15 weight portion, Herba Vernoniae Cinereae 15-20 weight portion, Herba Mimosae Pudicae 3-5 weight portion, Radix Polemonii Liniflori 15-20 weight portion and Semen Platycladi 8-15 weight portion.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Ligustri Lucidi 13 weight portion, Fructus Toosendan 3 weight portion, Rhizoma Trillii Tschonoskii 17 weight portion, Radix Arnebiae (Radix Lithospermi) 18 weight portion, Herba Goodyerae Procerae 9 weight portion, Herba Hippuridis Vulgaris 12 weight portion, Fructus Citri 12 weight portion, Semen Oroxyli 7 weight portion, Fructus Citri Sarcodactylis 15 weight portion, Radix Isatidis 18 weight portion, Fructus Mume 10 weight portion, Herba Inulae 2 weight portion, Herba Hedyotidis Diffusae 15 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 18 weight portion, Herba Commelinae 12 weight portion, Foliumet Ramulus Evodiae 15 weight portion, Radix Glycyrrhizae 16 weight portion, Herba Clinopodii Polycephali 8 weight portion, Herba Gnaphalii uliginosi 15 weight portion, Radix araliae chinensis (Cortex Araliae Chinensis) 3 weight portion, Herba Saxifragae 2 weight portion, Ramulus et Folium Adinae Piluliferae 3 weight portion, Cortex Fraxini 8 weight portion, Periostracum Cicadae 10 weight portion, Semen setariae 8 weight portion, Semen Ziziphi Spinosae 13 weight portion, Herba Vernoniae Cinereae 17 weight portion, Herba Mimosae Pudicae 3 weight portion, Radix Polemonii Liniflori 15 weight portion and Semen Platycladi 10 weight portion.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Ligustri Lucidi 12 weight portion, Fructus Toosendan 2 weight portion, Rhizoma Trillii Tschonoskii 18 weight portion, Radix Arnebiae (Radix Lithospermi) 13 weight portion, Herba Goodyerae Procerae 9 weight portion, Herba Hippuridis Vulgaris 12 weight portion, Fructus Citri 12 weight portion, Semen Oroxyli 7 weight portion, Fructus Citri Sarcodactylis 16 weight portion, Radix Isatidis 17 weight portion, Fructus Mume 10 weight portion, Herba Inulae 1 weight portion, Herba Hedyotidis Diffusae 16 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 17 weight portion, Herba Commelinae 9 weight portion, Foliumet Ramulus Evodiae 12 weight portion, Radix Glycyrrhizae 17 weight portion, Herba Clinopodii Polycephali 9 weight portion, Herba Gnaphalii uliginosi 16 weight portion, Radix araliae chinensis (Cortex Araliae Chinensis) 3 weight portion, Herba Saxifragae 2 weight portion, Ramulus et Folium Adinae Piluliferae 4 weight portion, Cortex Fraxini 8 weight portion, Periostracum Cicadae 9 weight portion, Semen setariae 10 weight portion, Semen Ziziphi Spinosae 12 weight portion, Herba Vernoniae Cinereae 16 weight portion, Herba Mimosae Pudicae 3 weight portion, Radix Polemonii Liniflori 16 weight portion and Semen Platycladi 10 weight portion.

In order to solve the problem, present invention also offers the preparation method of described medicine, wherein, the dosage form of described medicine is tablet, and its preparation method is:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 350 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.01 ~ 0.1 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.001 ~ 0.01 times of magnesium stearate, granulate, tabletting, makes.

Wherein, the dosage form of described medicine is capsule, and its preparation method is:

The first step, is mixed in proportion described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.1 ~ 0.5:0.1 ~ 0.5, incapsulate in housing, obtain capsule by described capsule 's content.

Wherein, the dosage form of described medicine is injection, and its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 96%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 20g ~ 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding and get final product.

Wherein, the dosage form of described medicine is: tablet, film coated tablet, sugar coated tablet, soft capsule drop, suck agent, granule, enteric coated tablet, electuary, honey pill agent, oral liquid, solution, sublimed preparation, suppository, syrup, injection, powder, liniment, spray, drop, patch and liniment.

The invention has the beneficial effects as follows: soothing liver-QI of the present invention benefit gallbladder, refrigerantly to reduce internal heat, damp eliminating heat extraction, effect of calming the nerves of fostering the spirit of nobility, cure mainly ascites of liver meridian damp-heat type bed-wetting.The present invention treats bed-wetting, internal and external application, effects a permanent cure while controlling table, and adopt natural Chinese medicines material, effective, curative effect is fast, do not recur, there is no toxic and side effects, great attention to whole idea, targeting is stronger, evident in efficacy, untoward reaction is less, can improve overall immunity simultaneously, timely symptom management, reduces the generation etc. of complication.

Detailed description of the invention

The present invention treats ascites of liver meridian damp-heat type bed-wetting, there is soothing liver-QI benefit gallbladder, refrigerantly to reduce internal heat, damp eliminating heat extraction, effect of calming the nerves of fostering the spirit of nobility, select following raw medicinal material: Fructus Ligustri Lucidi, Fructus Toosendan, Rhizoma Trillii Tschonoskii, Radix Arnebiae (Radix Lithospermi), Herba Goodyerae Procerae, Herba Hippuridis Vulgaris, Fructus Citri, Semen Oroxyli, Fructus Citri Sarcodactylis, Radix Isatidis, Fructus Mume, Herba Inulae, Herba Hedyotidis Diffusae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Commelinae, Foliumet Ramulus Evodiae, Radix Glycyrrhizae, Herba Clinopodii Polycephali, Herba Gnaphalii uliginosi, Radix araliae chinensis (Cortex Araliae Chinensis), Herba Saxifragae, Ramulus et Folium Adinae Piluliferae, Cortex Fraxini, Periostracum Cicadae, Semen setariae, Semen Ziziphi Spinosae, Herba Vernoniae Cinereae, Herba Mimosae Pudicae, Radix Polemonii Liniflori and Semen Platycladi.

Wherein, Fructus Ligustri Lucidi, Fructus Toosendan, Rhizoma Trillii Tschonoskii, Radix Arnebiae (Radix Lithospermi), Herba Goodyerae Procerae, Herba Hippuridis Vulgaris, Fructus Citri, Semen Oroxyli, Fructus Citri Sarcodactylis soothing liver-QI benefit gallbladder; Radix Isatidis, Fructus Mume, Herba Inulae, Herba Hedyotidis Diffusae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Commelinae, Foliumet Ramulus Evodiae, Radix Glycyrrhizae, Herba Clinopodii Polycephali is refrigerant reduces internal heat; Herba Gnaphalii uliginosi, Radix araliae chinensis (Cortex Araliae Chinensis), Herba Saxifragae, Ramulus et Folium Adinae Piluliferae, Cortex Fraxini, Periostracum Cicadae, Semen setariae damp eliminating heat extraction; Semen Ziziphi Spinosae, Herba Vernoniae Cinereae, Herba Mimosae Pudicae, Radix Polemonii Liniflori, Semen Platycladi are fostered the spirit of nobility and are calmed the nerves.Ingredients scientific matching, realize, to the treatment of ascites of liver meridian damp-heat type bed-wetting, reaching treating both the principal and secondary aspects of a disease, curative effect is very good.

Be the pharmacology of each medical material below:

Fructus Ligustri Lucidi: [nature and flavor] are bitter sweet, flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." [return through] enters liver, kidney channel.1. " Bencao Jingshu ": " enter meridian of Foot-SHAO YIN." 2. " book on Chinese herbal medicine is new again ": " enters liver, lung, kidney three warp." [function cures mainly] invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.1. " herbal classic ": " main invigorating middle warmer, settling five organs support spirit, except hundred diseases.Clothes fertilizer of a specified duration is strong." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " black palpus of hair color, strong rigidity of soft tissues power, takes wind of enriching blood more." 3. " detailed outline ": " reinforcing YIN-essence, strong waist knee joint, improving eyesight." 4. " Bencao Jingshu ": " removing heat from blood, beneficial blood." 5. " book on Chinese herbal medicine just ": " yin nourishing gas, Pingyin fire, separates dysphoria with smothery sensation hectic fever due to YIN-deficiency, and only sweating due to debility, quenches one's thirst, and stranguria with turbid discharge, and metrorrhagia, has blood in stool, hematuria, the erosion of vulva, anal fistula pain.Also clearing away liver-fire, can improving eyesight arresting lacrimation." 3. " book on Chinese herbal medicine is new again ": " replenishing YIN to strengthen the kidney, QI invigorating soothing liver-QI.Control lumbago and skelalgia, stimulate the menstrual flow and blood."

Fructus Toosendan: [nature and flavor] are bitter, cold.[return through] returns liver, small intestinal, urinary bladder channel.[function cures mainly] soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.

Rhizoma Trillii Tschonoskii: nature and flavor sweet, acrid, warm.1. " Shaanxi Chinese herbal medicine ": " sweet in the mouth is micro-pungent, warm in nature." 2. " Shennongjia Chinese herbal medicine ": " is sweet light, flat." [function cures mainly] dispels the wind, and soothing liver-QI is invigorated blood circulation, hemostasis.Control hypertension, dizzy headache, injury and bone fracture, lumbago and skelalgia, traumatic hemorrhage.1. " Shaanxi Chinese herbal medicine ": " hemostasis, analgesia, granulation promoting, except rheumatism, detumescence poison.Control traumatic hemorrhage, various lumbago, impairment caused by overstrain, traumatic injury, innominate toxic swelling." 2. " Zhejiang natural resources of Chinese medicinal materials register ": " dispels the wind, and divergence zone is mended." 3. " refreshing clothes hanger Chinese herbal medicine ": " dispel the wind soothing liver-QI, hemostasia and promoting granulation."

Radix Arnebiae (Radix Lithospermi): [nature and flavor] are bitter, cold.1. " herbal classic ": " bitter, cold." 2. " not Lu ": " be nontoxic." 3. " property of medicine opinion ": " is sweet, flat." 4. " detailed outline ": " is sweet salty, cold." [return through] enters percardium, Liver Channel.1. " detailed outline ": " enter percardium, Liver Channel blood system." 2. Lei Gong's Treatise on Preparation and Broiling of Materia Medica: " enters the heart, small intestinal two warp." 3. " Bencao Jingshu ": " enters few cloudy, the moon of fainting of foot." [function cures mainly] removing heat from blood, invigorates blood circulation, heat clearing away, removing toxic substances.Control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.1. " herbal classic ": " main trusted subordinate's pathogen, five types of jaundice, invigorating the spleen and replenishing QI, sharp nine orifices, waterway." 2. " not Lu ": " treats abdomen swelling completely pain.To close cream, treat children's's skin ulcer and face acne." 3. " property of medicine opinion ": " controls malignant boil, Guo tinea.Disease when " 4. " Bencao Tujing ": " cures the wound cold, sends out skin ulcer rash and does not go out person, make medicine, make it send with this." 5. " detailed outline ": " controls macule, pox poison, promoting blood circulation and cooling blood, sharp large intestine." 6. " medical center bun is wanted ": " reinforcing the heart, soothing liver-QI, dissipating blood stasis, invigorates blood circulation." 7. " Jilin Chinese herbal medicine ": " treats constipation, hematuria." 8. " Shaanxi Chinese herbal medicine ": " controls burn, dermatitis, eczema, urinary tract infection."

Herba Goodyerae Procerae: [nature and flavor] toil, temperature.1. " Zhiwu Mingshi Tukao ": " warm in nature, bitter in the mouth is nontoxic." 2. Chengdu " conventional herbtherapy handbook ": " is warm in nature, and bitter in the mouth is pungent." [function cures mainly] expelling wind and removing dampness, tonifying the blood and stretching the tendon.Control anemofrigid-damp arthralgia, hemiplegia.1. " Zhiwu Mingshi Tukao ": " nourish blood, soothing liver-QI, QI invigorating, nourishing kidney.Enter muscle to dispel the wind, dehumidify to the marrow." 2. " conventional glossary of Herbs and Drugs among the people ": " controls arthralgia, and rheumatism is benumbed."

Herba Hippuridis Vulgaris: [nature and flavor] micro-sweet, bitter, cold.[function cures mainly] antitussive, soothing liver-QI, cooling blood for hemostasis, YIN nourishing and the production of body fluid promoting, deep steaming.Cure mainly high hot excessive thirst, tuberculosis is coughed, the hot hectic fever due to YIN-deficiency of consumptive disease, pain in the hypochondrium, gastroenteritis etc.Stem, leaf external control traumatic hemorrhage.

Fructus Citri: [nature and flavor] are pungent, bitter, sour, temperature.[return through] returns liver, spleen, lung meridian.[function cures mainly] liver-smoothing, qi-regulating, alleviating distention in middle-JIAO, reduces phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavity abdomen feeling of fullness, vomiting eructation, abundant expectoration is coughed.

Semen Oroxyli: [nature and flavor] are bitter, sweet, cool.[return through] returns lung, liver, stomach warp.[function cures mainly] removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach.For cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach.

Fructus Citri Sarcodactylis: [nature and flavor] arduous acid, temperature.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature, sweet in the mouth is micro-pungent." 2. " detailed outline ": " is sad, nontoxic." 8. " herbal classic is met former ": " is arduous sweet, temperature, nontoxic." [return through] enters liver, stomach warp.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter liver, stomach two warp." 2. " book on Chinese herbal medicine is new again ": " enters liver, spleen, stomach three warp." 3. " book on Chinese herbal medicine brief points ": " starts with, meridian of Foot-TAI YIN." [function cures mainly] regulates the flow of vital energy, and reduces phlegm.Treat for stomachache, coerce swollen, vomiting, dysphagic, phlegm retention cough with asthma, and can relieve the effect of alcohol.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold syndrome of the stomach that disappears expectorant, controls gastric qi pain for tonifying liver warming the stomach, anti-nausea.The only cold pain in face, and middle circulation of qi promoting." 2. " detailed outline ": " boils beverage, controls mental disorder cough.Decoct soup, control pain due to disorder of QI under the heart." 3. " herbal classic is met former ": " be broken stagnant gas specially.Control after under dysentery heavy, get old person and use it." 4. " book on Chinese herbal medicine is new again ": " controls gas soothing liver-QI, and stomach function regulating reduces phlegm, removing mass, controls dysphagia and regurgitation, eliminating mass abdominal mass scrofula." 5. " occupying diet spectrum with breath ": " stomach eliminating phlegm of waking up, ward off evil, neutralize the effect of alcoholic drinks, help digestion pain relieving."

Radix Isatidis: [nature and flavor] are bitter, cold.1. " book on Chinese herbal medicine is stated ": " bitter, cold, nontoxic." 2. " classifying herbal ": " is cool." [return through] " book on Chinese herbal medicine is just read ": " enters liver, stomach blood system." [function cures mainly] heat clearing away, removing toxic substances, removing heat from blood.Control influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, pyretic toxicity sends out speckle, and coma tells nosebleed, pharyngeal swelling, mumps, acute catarrhal conjunctivitis, skin ulcer rash, and crimson tongue is purple dark, sore throat, scarlet fever, major part pestilence, carbuncle; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.

Fructus Mume: [nature and flavor] acid, temperature.1. " herbal classic ": " sour in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. " Japan hanako materia medica ": " warms up, nontoxic." 4. " medicine origin ": " gas is trembled with fear, sour in the mouth." [return through] enters liver, spleen, lung, large intestine channel.1. Wang Haogu: " enter spleen, lung two through blood system." 2. " Thunder God concocts property of medicine solution ": " enters lung, kidney two warp." 3. " Bencao Jingshu ": " enters liver." 4. " medicineization justice ": " enters lung, stomach, large intestine three warp." [function cures mainly] convergence is promoted the production of body fluid, relieving colic caused by ascaris anthelmintic.Control chronic cough, deficiency-heat excessive thirst, chronic malaria, chronic diarrhea, dysentery, has blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.

Herba Inulae: [nature and flavor] are salty, temperature.1. " Suzhou this product medical material ": " salty toil, temperature." 2. " Traditional Chinese Medicine in Sichuan will ": " salty in the mouth, warm in nature." [return through] " Traditional Chinese Medicine in Sichuan will ": " enters lung, large intestine two warp." [function cures mainly] dispersing wind and cold, reduce phlegm drink, detumescence poison.Control cough due to wind and cold, latent fluid-retention phlegm dyspnea, distending pain in the hypochondrium, furuncle, toxic swelling.1. " Japan hanako materia medica ": " only incised wound blood." 2. " detailed outline ": " controls furuncle swelling toxin." 3. " classifying herbal ": " is controlled children's's salt and coughs, and salt is shouted, and rushes rice juice clothes." 4. " Tian Bao book on Chinese herbal medicine ": " lung heat clearing heat extraction, cold expelling reduces internal heat.Stopping vomiting is breathed with cough and is coughed, and tells nosebleed, has one's ideas straightened out treating stranguria." 5. " Nanjing medicinal herbs among the people ": " Seedling: damp eliminating, draws out pus by applying a plaster to the affected part, and detumescence, disperses." 6. " Traditional Chinese Medicine in Sichuan will ": " relieving cough and resolving phlegm, Dingchuan is except drink.Control heart spleen latent fluid-retention, distending pain in the hypochondrium, expectorant knot in lung, saliva is as shellac varnish, and pathogenic wind arthralgia chiefly caused by damp pathogen." 7. " Shaanxi Chinese herbal medicine ": " has relaxing muscles and tendons to promote blood circulation effect."

Herba Hedyotidis Diffusae: nature and flavor are sweet, light, cool.[return through] enters stomach, large intestine, small intestine meridian.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.

Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae): [nature and flavor] Guangzhou army " conventional Chinese herbal medicine handbook ": " bitter, cold." [function cures mainly] heat-clearing and toxic substances removing, benefiting stomach and stopping pain, dissipating blood stasis for subsidence of swelling.Control exogenous cough, pharyngalgia, aphtha of the mouth and tongue, vomiting and diarrhoea, dysentery, stomachache, swollen ulcer drug, traumatic injury.1. Guangzhou army " conventional Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing, eliminating stasis to stop pain.Control stomach and duodenum to burst hemorrhoid pain, treating swelling and pain by traumatic injury, neuralgia, toothache, acute gastroenteritis, bacillary dysentery, upper respiratory tract infection, pharyngalgia." 2. " conventional Chinese herbal medicine color atlas ": " benefiting stomach and stopping pain, subduing swelling and detoxicating." 3. Guangzhou air force " conventional Chinese herbal medicine handbook ": " controls pulmonary tuberculosis, carbuncle skin ulcer, abscess, dyspepsia, stomatitis." 4. " mountain of papers Chinese herbal medicine ": " treats for stomachache, abdominal distention, diarrhoea, malaria." 5. Nanchuan " conventional Chinese herbal medicine handbook ": " controls boil on the nape opposite the mouth and burn."

Herba Commelinae: nature and flavor are sweet, light, cold.[return through] returns lung, stomach, small intestine meridian.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema.For anemopyretic cold, hyperpyrexia, laryngopharynx swelling and pain, edema oliguria, the puckery pain of pyretic stranguria, carbuncle furunculosis.

Foliumet Ramulus Evodiae: [nature and flavor] are bitter, cold.[function cures mainly] heat-clearing and toxic substances removing, eliminating stasis to stop pain.Prevent and treat influenza, epidemic cerebrospinal meningitis, encephalitis B, heatstroke, cure cold high heat, tonsillitis, pharyngolaryngitis, lung abscess, pneumonia, malaria, rheumatic arthritis, sciatica, lumbago and skelalgia, stomachache, icterohepatitis, Gelsemium elegans Benth. (Herba Gelsemii Elegantis) is poisoning.Osteopatia sprain is controlled in external, worm venom, carbuncle furuncle and phyma poison, trauma infection contamination, eczema, dermatitis.

Radix Glycyrrhizae: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Herba Clinopodii Polycephali: [nature and flavor] are pungent, bitter, cool.[function cures mainly] wind and heat dispersing, removing toxic substances dysentery relieving, hemostasis.For flu, heatstroke, dysentery, hepatitis; Furuncle swelling toxin, skin pruritus, traumatic hemorrhage are controlled in external.

Herba Gnaphalii uliginosi: [nature and flavor] are " Chinese herbal medicine handbook is commonly used in northeast " 1.: " sweet, flat." 2. " plateau Chinese herbal treatment handbook ": " is sweet, is slightly cold." [return through] " plateau Chinese herbal treatment handbook ": " enters lung, intestine and small intestine warp.", in tune, blood pressure lowering, the skin ulcer that disappears swells for [function cures mainly] relieving cough and resolving phlegm, damp eliminating.Control cough and asthma, bones and muscles pain, hygropyretic dysentery, gastric ulcer, hypertension, carbuncle pyogenic infections from tumour or sore.

Radix araliae chinensis (Cortex Araliae Chinensis): [nature and flavor] are pungent is flat.1. supplement to the Herbal: " pungent, flat." 2. " vegetation is side just ": " is bitter, is slightly cold." 3. " Kweiyang medicinal herbs among the people ": " is sweet, cold, nontoxic." [function cures mainly] wind-damp dispelling, diuresis, dissipating blood stasis blood, detumescence poison.Treating rheumatic arthritis, oedema due to nephritis, cirrhotic ascites, acute, chronic hepatitis, stomachache, stranguria with turbid discharge, metrorrhagia, traumatic injury, scrofula, carbuncle.

Herba Saxifragae: [nature and flavor] are 《 Lv Cliff rock book on Chinese herbal medicine 1. ": " cool in nature." 2. " detailed outline ": " micro-toil, cold." [function cures mainly] dispels the wind, heat clearing away, removing pathogenic heat from blood and toxic substance from the body.Control rubella; Eczema, otitis media, erysipelas, cough is spitted blood, lung abscess, metrorrhagia, haemorrhoids.

Ramulus et Folium Adinae Piluliferae: [nature and flavor] are bitter is flat.1. " Fujian traditional herbal medicine ": " bitter, flat." 2. " Luchuan book on Chinese herbal medicine ": " is sweet light, is slightly cold." 3. " Nanning City's medicine will ": " is puckery." [function cures mainly] clearing away heat-damp and promoting diuresis, repercussive analgesic therapy, hemostasia and promoting granulation.Control dysentery, enteritis, damp and hot edema, carbuncle sore tumefacting virus, eczema, rotten foot, ulcer being unable to heal, wound hemorrhage.1. " Li Shi grass is secret ": " control injury by metallic tools, year rotten foot sore of a specified duration, smash skin, leaf, on net for catching birds or fish." 2. " Fujian traditional herbal medicine ": " leaf or flower: hemostasis of drawing out pus by applying a plaster to the affected part is Incised wound medicine." 3. " Luchuan book on Chinese herbal medicine ": " branch, leaf: eliminating inflammation and expelling toxin removing the necrotic tissue.Control skin infections poison, carbuncle sore ulceration." 4. " Nanning City's medicine will ": " restrains, parasite killing.Control eczema, scabies, acute diseases such as cholera and sunstroke worm foot." 5. Guangzhou army " conventional Chinese herbal medicine handbook ": " controls dysentery, acute gastroenteritis (with flowers and fruits); Traumatic injury, fracture (with leaf)."

Cortex Fraxini: [nature and flavor] are bitter, puckery, cold.[return through] returns liver, gallbladder, large intestine channel.[function cures mainly] heat clearing and damp drying, astringent therapy, improving eyesight.For hematodiarrhoea, have loose bowels, leucorrhea with red and white discharge, conjunctival congestion and swelling pain, the raw nebula film of order.

Periostracum Cicadae: [nature and flavor] are sweet, cold.[return through] returns lung, Liver Channel.[function cures mainly] falls apart wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.

Semen setariae: [nature and flavor] are sweet salty, cool.Old Semen setariae: bitter, cold.1. " not Lu ": " salty in the mouth, is slightly cold, nontoxic.Old Semen setariae: bitter in the mouth." 2. amplification on Canon of Materia Medica: " old Semen setariae: property is cold." 3. " detailed outline ": " degree of saltiness." 4. essentials of Matea Medica: " is sweet salty, is slightly cold." 5. " Luchuan book on Chinese herbal medicine ": " is sweet, flat." [returning through] 1. " book on Chinese herbal medicine is looked for the truth ": " specially enters kidney, double enter spleen, stomach." 2. " book on Chinese herbal medicine brief points ": " enters that brothers are lunar, shaoyin channel." [function cures mainly] and in, kidney tonifying, heat extraction, removing toxic substances.Control taste deficiency-heat, regurgitation is vomitted, and quenches one's thirst, has loose bowels.Old Semen setariae: dysentery relieving, separates unhappy.

Semen Ziziphi Spinosae: [nature and flavor] are sweet is flat.1. " herbal classic ": " sour in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. amplification on Canon of Materia Medica: " tepor." 4. principle of Correct Diet: " sour in the mouth is sweet, flat." [return through] enters the heart, spleen, liver, gallbladder meridian.1. " detailed outline ": " sufficient the moon of fainting, few sun." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen, liver, gallbladder four warp." [function cures mainly] nourishing the liver, mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.

Herba Vernoniae Cinereae: [nature and flavor] " Guangdong Chinese medicine " II: " cool in nature, lightly seasoned, one says bitter in the mouth, cool in nature." [function cures mainly] heat clearing away, dehumidifying, removing toxic substances.Control fever caused by exogenous pathogens, acute icterohepatitis, damp-heat diarrhea, furuncle swelling toxin.1. " south of the Five Ridges gather medicinal herbs record ": " control fever caused by exogenous pathogens, except damp and hot." 2. " Guangdong Chinese medicine " II: " heat-clearing and toxic substances removing, detumescence and drawing out poison, evacuation of pus.Control damp-heat diarrhea, and control breast ulcer, venom." 3. Guangzhou army " conventional Chinese herbal medicine handbook ": " liver heat removing is brought down a fever, calmness of calming the nerves.Cure cold heating, cough, acute icterohepatitis, neurasthenia, insomnia, children's's nocturia, furuncle swelling toxin."

Herba Mimosae Pudicae: nature and flavor are sweet, puckery, cool.[function cures mainly] clearing away heat and promoting diuresis, preventing phlegm from forming and stopping coughing, ataralgesia.For flu, infantile hyperpyrexia, acute conjunctivitis, bronchitis, gastritis, enteritis, urinary system calculus, malaria, neurasthenia; Treating swelling and pain by traumatic injury is controlled in external, sore swollen toxin.

Radix Polemonii Liniflori: [nature and flavor] are bitter; Flat [return through] lung; The heart; Liver; Spleen; Stomach warp.[function cures mainly] reduces phlegm; Calm the nerves; Hemostasis.Main cough with copious phlegm; Epilepsy; Insomnia; Spitting of blood; Nosebleed is bent; Spit blood; Have blood in stool; Menorrhagia.

Semen Platycladi: [nature and flavor] are sweet is flat.[return through] GUIXIN, kidney, large intestine channel.[function cures mainly] tranquilizing by nourishing the heart, hidroschesis, intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.

Described medicine preferably only has said medicine to obtain.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet

Formula: Fructus Ligustri Lucidi 12 parts, Fructus Toosendan 3 parts, Rhizoma Trillii Tschonoskii 15 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, Herba Goodyerae Procerae 8 parts, Herba Hippuridis Vulgaris 9 parts, Fructus Citri 12 parts, Semen Oroxyli 6 parts, Fructus Citri Sarcodactylis 12 parts, Radix Isatidis 22 parts, Fructus Mume 8 parts, Herba Inulae 2 parts, Herba Hedyotidis Diffusae 17 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 15 parts, Herba Commelinae 8 parts, Foliumet Ramulus Evodiae 12 parts, 23 parts, Radix Glycyrrhizae, Herba Clinopodii Polycephali 8 parts, Herba Gnaphalii uliginosi 15 parts, Radix araliae chinensis (Cortex Araliae Chinensis) 3 parts, Herba Saxifragae 2 parts, Ramulus et Folium Adinae Piluliferae 3 parts, Cortex Fraxini 8 parts, Periostracum Cicadae 12 parts, Semen setariae 8 parts, Semen Ziziphi Spinosae 12 parts, Herba Vernoniae Cinereae 17 parts, Herba Mimosae Pudicae 3 parts, Radix Polemonii Liniflori 14 parts and Semen Platycladi 12 parts.

Its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 350 ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.1 times, 0.05 times of lactose, the starch of 0.1 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.005 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2 capsule

Formula: Fructus Ligustri Lucidi 13 parts, Fructus Toosendan 3 parts, Rhizoma Trillii Tschonoskii 17 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, Herba Goodyerae Procerae 9 parts, Herba Hippuridis Vulgaris 12 parts, Fructus Citri 12 parts, Semen Oroxyli 7 parts, Fructus Citri Sarcodactylis 15 parts, Radix Isatidis 18 parts, Fructus Mume 10 parts, Herba Inulae 2 parts, Herba Hedyotidis Diffusae 15 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 18 parts, Herba Commelinae 12 parts, Foliumet Ramulus Evodiae 15 parts, 16 parts, Radix Glycyrrhizae, Herba Clinopodii Polycephali 8 parts, Herba Gnaphalii uliginosi 15 parts, Radix araliae chinensis (Cortex Araliae Chinensis) 3 parts, Herba Saxifragae 2 parts, Ramulus et Folium Adinae Piluliferae 3 parts, Cortex Fraxini 8 parts, Periostracum Cicadae 10 parts, Semen setariae 8 parts, Semen Ziziphi Spinosae 13 parts, Herba Vernoniae Cinereae 17 parts, Herba Mimosae Pudicae 3 parts, Radix Polemonii Liniflori 15 parts and Semen Platycladi 10 parts.

Its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 90%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.1:0.1, incapsulate in housing, obtain capsule by described capsule 's content.

Embodiment 3 injection

Formula: Fructus Ligustri Lucidi 12 parts, Fructus Toosendan 2 parts, Rhizoma Trillii Tschonoskii 18 parts, Radix Arnebiae (Radix Lithospermi) 13 parts, Herba Goodyerae Procerae 9 parts, Herba Hippuridis Vulgaris 12 parts, Fructus Citri 12 parts, Semen Oroxyli 7 parts, Fructus Citri Sarcodactylis 16 parts, Radix Isatidis 17 parts, Fructus Mume 10 parts, Herba Inulae 1 part, Herba Hedyotidis Diffusae 16 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 17 parts, Herba Commelinae 9 parts, Foliumet Ramulus Evodiae 12 parts, 17 parts, Radix Glycyrrhizae, Herba Clinopodii Polycephali 9 parts, Herba Gnaphalii uliginosi 16 parts, Radix araliae chinensis (Cortex Araliae Chinensis) 3 parts, Herba Saxifragae 2 parts, Ramulus et Folium Adinae Piluliferae 4 parts, Cortex Fraxini 8 parts, Periostracum Cicadae 9 parts, Semen setariae 10 parts, Semen Ziziphi Spinosae 12 parts, Herba Vernoniae Cinereae 16 parts, Herba Mimosae Pudicae 3 parts, Radix Polemonii Liniflori 16 parts and Semen Platycladi 10 parts.

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 1 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 96%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 36 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 30g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding and get final product.

Toxicity test

1. acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 8g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 40g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>40g crude drug/kg of the present invention, every day, maximum dosage-feeding was 80g crude drug/kg/ day.Clinical drug dosage of the present invention be 5g crude drug/day/people, adult body weight in 60KG, average dosage is 0.083g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage medicine of the present invention is 964 times of quantity.Therefore drug anesthesia Acute toxicity of the present invention is low, clinical drug safety.

2. cumulative toxicity test: test method: select 20 healthy mices, female, each 10 of hero, with the injection of the embodiment of the present invention 3 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Medicine of the present invention is described, does not there is cumulative toxicity.

Clinical trial

Case selection: during selecting in May ,-2013 in May, 2012, affected children ranges totally 200 examples of the ascites of liver meridian damp-heat type bed-wetting of certain children's hospital's diagnosis and treatment.Wherein, man 115 example, female 85 example, 5 years old-8 years old age 115 example, 8 years old-10 years old 65 example, 11-15 year 20example.Be divided into four groups at random, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group.Four groups of infants comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.

Diagnostic criteria:

The enuresis refers to more than 5 years old child, can not Autonomous Control urinate, bed wetter after often falling asleep.

Diagnosis basis

1, sleep is comparatively dark, not easily wakes up, wets the bed every night or every several days, and very then a nocturia bed for several times.

2, age of onset is more than 5 one full year of life.

3, urine routine and urine cultivate discovery how without exception.

4, x-ray takes the photograph sheet inspection, and part infant can find that there is spina bifida occulta, urinary system x-ray radiography its textural anomaly visible.

5, ascites of liver meridian damp-heat type: the middle enuresis of sleeping, frequent micturition amount is few, irascible temperament, feverish sensation in the palms and soles, red lip and doing.Red tongue, yellow fur, stringy and rolling pulse.

Therapeutic Method:

Embodiment 1 group: this group uses the tablet of embodiments of the invention 1 to treat.Tablet dose to be dissolved in the water or in milk, the amount of gavaging be 1.5g crude drug amount/time, gavage 2 times on the one, January is a course for the treatment of, treats 2 courses for the treatment of.

Embodiment 2 groups: this group uses the capsule of embodiments of the invention 2 to treat.Every day 2 times, sooner or later each once, each 1 oral.January is a course for the treatment of, treats 2 courses for the treatment of.

Embodiment 3 groups: this group uses the injection of embodiments of the invention 3 to treat.Every day 1 time, each intramuscular injection 2.5ml.January is a course for the treatment of, treats 2 courses for the treatment of.

Matched group: this group uses acetic acid to go amine vassopressin to treat.10 ~ 40ug/d, uses before sleeping.January is a course for the treatment of, treats 2 courses for the treatment of.

The standard of curative effect evaluation:

Cure: the not enuresis again after controlling.

Take a turn for the better: enuresis number of times reduces, and can wake and urinate in sleep.

Do not heal: the enuresis is unchanged.

Therapeutic outcome

Table 1 is the treatment situation contrast of each group

Group	Cure	Take a turn for the better	Do not heal
				Embodiment 1 group	49（98%）	1（2%）	0（0%）
Embodiment 2 groups	50（100%）	0（0%）	0（0%）
				Embodiment 3 groups	50（100%）	0（0%）	0（0%）
Matched group	20（40%）	10（20%）	20（40%）

As can be seen from Table 1, the treatment situation of three embodiment groups is better than the therapeutic effect of matched group, it can thus be appreciated that medicine of the present invention, at treatment ascites of liver meridian damp-heat type bed-wetting, therapeutic effect is good, determined curative effect.

Table 2 is the treatment time contrast of the healing of each group

Group	Healing number	First course for the treatment of	Second course for the treatment of
				Embodiment 1 group	49	24（49%）	25（51%）
Embodiment 2 groups	50	29（58%）	21（42%）
				Embodiment 3 groups	50	28（56%）	22（44%）
Matched group	20	8（40%）	12（60%）

As can be seen from Table 2, the healing number that first course for the treatment of of three embodiment groups cures is higher than matched group, it can thus be appreciated that medicine of the present invention, at treatment ascites of liver meridian damp-heat type bed-wetting, treatment speed is fast, instant effect.

Model case: children's hospital of Shandong Province accepts the boy of diagnosis and treatment, 9 years old, suffers from bed-wetting half a year.Symptoms is: the middle enuresis of sleeping, and frequent micturition amount is few, irascible temperament, feverish sensation in the palms and soles, red lip and doing.Red tongue, yellow fur, stringy and rolling pulse is ascites of liver meridian damp-heat type.The tablet of embodiments of the invention 1 is used to treat.Tablet dose to be dissolved in the water or in milk, the amount of gavaging be 1.5g crude drug amount/time, gavage 2 times on the one, January is a course for the treatment of, treats 2 courses for the treatment of.January is a course for the treatment of, treats 2 courses for the treatment of.In therapeutic process, do not occur other untoward reaction, 2 courses for the treatment of are carried out in treatment, cure.Later stage follows up half a year, does not recur.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. treat the medicine of ascites of liver meridian damp-heat type bed-wetting for one kind, it is characterized in that, comprise following raw medicinal material: Fructus Ligustri Lucidi, Fructus Toosendan, Rhizoma Trillii Tschonoskii, Radix Arnebiae (Radix Lithospermi), Herba Goodyerae Procerae, Herba Hippuridis Vulgaris, Fructus Citri, Semen Oroxyli, Fructus Citri Sarcodactylis, Radix Isatidis, Fructus Mume, Herba Inulae, Herba Hedyotidis Diffusae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Commelinae, Foliumet Ramulus Evodiae, Radix Glycyrrhizae, Herba Clinopodii Polycephali, Herba Gnaphalii uliginosi, Radix araliae chinensis (Cortex Araliae Chinensis), Herba Saxifragae, Ramulus et Folium Adinae Piluliferae, Cortex Fraxini, Periostracum Cicadae, Semen setariae, Semen Ziziphi Spinosae, Herba Vernoniae Cinereae, Herba Mimosae Pudicae, Radix Polemonii Liniflori and Semen Platycladi.

2. medicine as claimed in claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Ligustri Lucidi 10-15 weight portion, Fructus Toosendan 2-4 weight portion, Rhizoma Trillii Tschonoskii 12-23 weight portion, Radix Arnebiae (Radix Lithospermi) 10-20 weight portion, Herba Goodyerae Procerae 7-13 weight portion, Herba Hippuridis Vulgaris 8-15 weight portion, Fructus Citri 10-15 weight portion, Semen Oroxyli 5-10 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Radix Isatidis 15-25 weight portion, Fructus Mume 7-12 weight portion, Herba Inulae 1-3 weight portion, Herba Hedyotidis Diffusae 10-20 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 15-20 weight portion, Herba Commelinae 7-13 weight portion, Foliumet Ramulus Evodiae 10-20 weight portion, Radix Glycyrrhizae 15-25 weight portion, Herba Clinopodii Polycephali 6-12 weight portion, Herba Gnaphalii uliginosi 10-20 weight portion, Radix araliae chinensis (Cortex Araliae Chinensis) 2-4 weight portion, Herba Saxifragae 1-3 weight portion, Ramulus et Folium Adinae Piluliferae 2-5 weight portion, Cortex Fraxini 6-13 weight portion, Periostracum Cicadae 8-14 weight portion, Semen setariae 6-13 weight portion, Semen Ziziphi Spinosae 10-15 weight portion, Herba Vernoniae Cinereae 15-20 weight portion, Herba Mimosae Pudicae 3-5 weight portion, Radix Polemonii Liniflori 10-20 weight portion and Semen Platycladi 8-15 weight portion.

3. medicine as claimed in claim 1 or 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Ligustri Lucidi 10-15 weight portion, Fructus Toosendan 2-4 weight portion, Rhizoma Trillii Tschonoskii 16-23 weight portion, Radix Arnebiae (Radix Lithospermi) 10-16 weight portion, Herba Goodyerae Procerae 7-13 weight portion, Herba Hippuridis Vulgaris 8-15 weight portion, Fructus Citri 10-15 weight portion, Semen Oroxyli 5-10 weight portion, Fructus Citri Sarcodactylis 15-20 weight portion, Radix Isatidis 15-20 weight portion, Fructus Mume 7-12 weight portion, Herba Inulae 1-3 weight portion, Herba Hedyotidis Diffusae 15-20 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 15-20 weight portion, Herba Commelinae 7-13 weight portion, Foliumet Ramulus Evodiae 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, Herba Clinopodii Polycephali 6-12 weight portion, Herba Gnaphalii uliginosi 15-20 weight portion, Radix araliae chinensis (Cortex Araliae Chinensis) 2-4 weight portion, Herba Saxifragae 1-3 weight portion, Ramulus et Folium Adinae Piluliferae 2-5 weight portion, Cortex Fraxini 6-13 weight portion, Periostracum Cicadae 8-14 weight portion, Semen setariae 6-13 weight portion, Semen Ziziphi Spinosae 10-15 weight portion, Herba Vernoniae Cinereae 15-20 weight portion, Herba Mimosae Pudicae 3-5 weight portion, Radix Polemonii Liniflori 15-20 weight portion and Semen Platycladi 8-15 weight portion.

4. the medicine as described in any one of claims 1 to 3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Ligustri Lucidi 13 weight portion, Fructus Toosendan 3 weight portion, Rhizoma Trillii Tschonoskii 17 weight portion, Radix Arnebiae (Radix Lithospermi) 18 weight portion, Herba Goodyerae Procerae 9 weight portion, Herba Hippuridis Vulgaris 12 weight portion, Fructus Citri 12 weight portion, Semen Oroxyli 7 weight portion, Fructus Citri Sarcodactylis 15 weight portion, Radix Isatidis 18 weight portion, Fructus Mume 10 weight portion, Herba Inulae 2 weight portion, Herba Hedyotidis Diffusae 15 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 18 weight portion, Herba Commelinae 12 weight portion, Foliumet Ramulus Evodiae 15 weight portion, Radix Glycyrrhizae 16 weight portion, Herba Clinopodii Polycephali 8 weight portion, Herba Gnaphalii uliginosi 15 weight portion, Radix araliae chinensis (Cortex Araliae Chinensis) 3 weight portion, Herba Saxifragae 2 weight portion, Ramulus et Folium Adinae Piluliferae 3 weight portion, Cortex Fraxini 8 weight portion, Periostracum Cicadae 10 weight portion, Semen setariae 8 weight portion, Semen Ziziphi Spinosae 13 weight portion, Herba Vernoniae Cinereae 17 weight portion, Herba Mimosae Pudicae 3 weight portion, Radix Polemonii Liniflori 15 weight portion and Semen Platycladi 10 weight portion.

5. the medicine as described in any one of Claims 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Ligustri Lucidi 12 weight portion, Fructus Toosendan 2 weight portion, Rhizoma Trillii Tschonoskii 18 weight portion, Radix Arnebiae (Radix Lithospermi) 13 weight portion, Herba Goodyerae Procerae 9 weight portion, Herba Hippuridis Vulgaris 12 weight portion, Fructus Citri 12 weight portion, Semen Oroxyli 7 weight portion, Fructus Citri Sarcodactylis 16 weight portion, Radix Isatidis 17 weight portion, Fructus Mume 10 weight portion, Herba Inulae 1 weight portion, Herba Hedyotidis Diffusae 16 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 17 weight portion, Herba Commelinae 9 weight portion, Foliumet Ramulus Evodiae 12 weight portion, Radix Glycyrrhizae 17 weight portion, Herba Clinopodii Polycephali 9 weight portion, Herba Gnaphalii uliginosi 16 weight portion, Radix araliae chinensis (Cortex Araliae Chinensis) 3 weight portion, Herba Saxifragae 2 weight portion, Ramulus et Folium Adinae Piluliferae 4 weight portion, Cortex Fraxini 8 weight portion, Periostracum Cicadae 9 weight portion, Semen setariae 10 weight portion, Semen Ziziphi Spinosae 12 weight portion, Herba Vernoniae Cinereae 16 weight portion, Herba Mimosae Pudicae 3 weight portion, Radix Polemonii Liniflori 16 weight portion and Semen Platycladi 10 weight portion.

6. the medicine as described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is tablet, and its preparation method is:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 350 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.01 ~ 0.1 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.001 ~ 0.01 times of magnesium stearate, granulate, tabletting, makes.

7. the medicine as described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is capsule, and its preparation method is:

The first step, is mixed in proportion described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.1 ~ 0.5:0.1 ~ 0.5, incapsulate in housing, obtain capsule by described capsule 's content.

8. a preparation method for the medicine described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is injection, and its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 96%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 20g ~ 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding and get final product.

9. the medicine as described in any one of claim 1 to 5, it is characterized in that, the dosage form of described medicine is: tablet, film coated tablet, sugar coated tablet, soft capsule drop, suck agent, granule, enteric coated tablet, electuary, honey pill agent, oral liquid, solution, sublimed preparation, suppository, syrup, injection, powder, liniment, spray, drop, patch and liniment.