CN105535518A - Medicine composition for treating senile liver and kidney deficiency type dizziness and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine composition for treating senile liver and kidney deficiency type dizziness and a preparation method thereof. The medicine composition comprises the following raw medicinal materials: Chinese wolfberry fruits, syzygium aromaticum, sheep livers, rhizoma arisaematis, fiveleaf akebia fruits, a Chinese pyrola herb, dragonflies, fleece-flower roots, an unpleasant swallowwort herb, wilford swallowwort roots, fragrant solomonseal rhizomes, Chinese mahonia, a denseflower bulbophyllum herb, mirabilite, Chinese cynomorium, polyporus cuticularis, a common clubmoss herb, garden balsam stems, Szechwan lovage rhizomes, Chinese horsechestnut fruits, Juncus effusus L, spina date seeds, polygala tenuifolia, lotus seeds and shrubberry rhodiola roots. The medicine composition has the advantages of treating the senile liver and kidney deficiency type dizziness, having the effects of tonifying the liver, tonifying the kidney, nourishing yin, moistening dryness, strengthening brain, regulating menstruation and tranquilizing mind by nourishing the heart, being good in effect and quick in curative effect and enabling the dizziness not to easily relapse by scientifically conditioning a body, being free of toxic and side effects and being suitable for the old to take.

Description

A kind ofly treat dizzy pharmaceutical composition of senile deficiency of yang of liver and kidney type and preparation method thereof

Technical field

The present invention relates to tcm field, particularly a kind ofly treat dizzy pharmaceutical composition of senile deficiency of yang of liver and kidney type and preparation method thereof.

Background technology

Senile megrim is usually expressed as spinning sensation, Balance disorders and sense of imbalance.Feel when patient opens eyes that self rotates, rocks, just as ship by bus.Can not stand during outbreak, symptom is increased with vagal tones such as Nausea and vomiting, tinnitus, perspiration, bradycardia and blood pressure drops, general last for several minutes is to a few hours, sometimes reaching a couple of days is taken in the vestibular system of internal ear, visual system and the proprioreceptor that is positioned at joint when importing the asymmetric information put in place with vestibular ganglion into, can make to be positioned at cerebellum and corticocerebral control axis produces spinning sensation.

Pathogeny and characteristics: 1, vestibular system degenerative change, senile degenerative changes can occur in any position of vestibular system in one or both sides, research confirms that old people vestibular system can occur that otolith device, ampulla ridge and the degeneration of capsule speckle epithelium, balloon membrane are broken, capsule Mylabris Leukopenia 20%, ampulla ridge hair cell reduce 40%, endolymph fluid pipe and endolymph cyst wall calcific deposit and hyaloid just, a series of pathological changes such as vestibule axoneuron minimizing.Due to the information asymmetry imported into, vestibule maincenter can not Correct Analysis and occur dizzy or dizzy sense.2, multisystem pathological changes, balance is maintained by the mutual coordination of visual system, proprioceptive system and vestibular system, wherein vestibular system is most important, but because the differ signal that causes visual system to import maincenter into of eyes dioptric does not import the asymmetric information of maincenter into the proprioceptive system being positioned at large joint after symmetrical or cerebrovascular, what gerontal patient all can be made to produce in various degree is dizzy, so alternatively dizzy is also that the disorder of the organic balanced system of a kind of vision, proprioreceptor and vestibular system shows in the one of body.3, central vertigo is more than peripheral vertigo, it is central disease that senile megrim is about half, 1/4 is peripheral disease damage, show as vestibular hair cells and vestibular ganglion cell regression, someone analyzes 64 senile megrim patients, and wherein cerebral lesion person accounts for 36%, the all pathological changes 35% of vestibule, vestibule central pathological changes 13%, brainstem ischemia 2%, other account for 14%.Secondly the benign locations paroxysmal vertigo (34.3%) that in external Adult Groups, dizzy morbidity is maximum is maincenter paraequilibrium (7.7%) and Meniere (6.6%).4, cerebrovascular disease impact is large, and first the dizzy of old people's burst should consider cerebrovascular disease, because old infarction and cerebral hemorrhage have vertigo symptoms in various degree in early days.It is dizzy that to have be the clinical manifestation of patient Chang You after cerebrovascular.It is dizzy that hypertension, cerebral arteriosclerosis make vestibular system blood supply insufficiency often cause, and ear's symptom often can early than heart and brain symptom.But anoxia is light to the damage ratio cochlea of vestibule, therefore old people has more existing deafness, tinnitus and dizzy generation is relatively less.The cervical vertigo that cervical spondylosis causes sends out the age at 40-66 years old well, and vertebra basal layer blood supply insufficiency is the most common reason of old people.Hypertension, arteriosclerosis or atheromatous plaque are formed and cause posterior inferior cerebellar artery, labyrinthine artery blood supply insufficiency and occur dizzyly can be central or for peripheral.

Chinese medical discrimination, syndrome-classification: wind-yang and up-boring: vertigo and tinnitus, headache and swollen, irritability, insomnia and dreamful sleep, or flushing conjunctival congestion, bitter taste.Red tongue, yellow fur, stringy and rolling pulse.The turbid upper illiteracy of expectorant: heaviness of the head as if it were tightly bandaged, rotates depending on thing, uncomfortable in chestly to do evil, vomiting sputum.Tongue is greasy in vain, stringy and rolling pulse.Deficiency of qi and blood: have a dizzy spell, pale white complexion, god is tired weak, palpitation and sleeplessness.Light red tongue, white and thin fur, weak pulse.The hepatic and renal YIN deficiency: dizzy of a specified duration endlessly visual deterioration, sleeps forgetful less, vexed xerostomia, tinnitus, god is tired weak, soreness of waist and knee.Red tongue, thin fur, stringy and thready pulse.

According to Chinese medical discrimination, can treat to the ill according to different diseases.Therefore, how effective for this specific group of old people, to treat for deficiency of yang of liver and kidney type is dizzy, be the problem to be solved in the present invention.

Summary of the invention

In order to solve the problem, the invention provides and a kind ofly treat dizzy pharmaceutical composition of senile deficiency of yang of liver and kidney type and preparation method thereof.

In order to realize foregoing invention object, the invention provides and a kind ofly treat the dizzy pharmaceutical composition of senile deficiency of yang of liver and kidney type, wherein, obtained by the raw medicinal material of following mass fraction: Fructus Lycii 10-20 weight portion, Flos Caryophylli 15-20 weight portion, Hepar Caprae seu ovis 8-13 weight portion, Rhizoma Arisaematis 2-4 weight portion, Fructus Akebiae 5-10 weight portion, Herba Pyrolae 10-15 weight portion, Aeschna melanictera 8-13 weight portion, Radix Polygoni Multiflori 8-13 weight portion, Radix Tylophorae arenicolae 5-10 weight portion, Radix cynanchi wilfordii 8-13 weight portion, Rhizoma Polygonati Odorati 10-15 weight portion, Mahonia fortunei (Lindl.) Fedde 12-20 weight portion, Herba Bulbophylli Odoratissim 5-10 weight portion, Mirabilitum 8-13 weight portion, Herba Cynomorii 4-8 weight portion, close tree bacterium 4-8 weight portion, Herba Lycopodii 8-13 weight portion, Herba speranskiae tuberculatae 5-8 weight portion, Rhizoma Chuanxiong 6-9 weight portion, Semen Aesculi 8-13 weight portion, Medulla Junci 6-12 weight portion, Semen Ziziphi Spinosae 8-12 weight portion, Radix Polygalae 6-10 weight portion, Semen Nelumbinis 15-20 weight portion and Radix Rhodiolae Dumulosae 10-15 weight portion.

Wherein, the raw medicinal material of following mass fraction is had to obtain: Fructus Lycii 15 weight portion, Flos Caryophylli 17 weight portion, Hepar Caprae seu ovis 10 weight portion, Rhizoma Arisaematis 3 weight portion, Fructus Akebiae 6 weight portion, Herba Pyrolae 12 weight portion, Aeschna melanictera 10 weight portion, Radix Polygoni Multiflori 10 weight portion, Radix Tylophorae arenicolae 8 weight portion, Radix cynanchi wilfordii 10 weight portion, Rhizoma Polygonati Odorati 12 weight portion, Mahonia fortunei (Lindl.) Fedde 17 weight portion, Herba Bulbophylli Odoratissim 7 weight portion, Mirabilitum 10 weight portion, Herba Cynomorii 6 weight portion, close tree bacterium 6 weight portion, Herba Lycopodii 10 weight portion, Herba speranskiae tuberculatae 7 weight portion, Rhizoma Chuanxiong 8 weight portion, Semen Aesculi 10 weight portion, Medulla Junci 8 weight portion, Semen Ziziphi Spinosae 10 weight portion, Radix Polygalae 8 weight portion, Semen Nelumbinis 16 weight portion and Radix Rhodiolae Dumulosae 12 weight portion.

In order to achieve the above object, present invention also offers the preparation method of the dizzy pharmaceutical composition of described treatment senile deficiency of yang of liver and kidney type, comprise the following steps:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes tablet.

Or preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.05 ~ 0.2:0.05 ~ 0.2, incapsulate in housing, obtain capsule by described capsule 's content.

The invention has the beneficial effects as follows: medicine of the present invention, treat senile deficiency of yang of liver and kidney type dizzy, there is effect of the liver and the kidney tonifying, nourshing Yin and drynsessmoistening prescription, brain-strengthening regulating menstruation and tranquilizing by nourishing the heart, by nursing one's health the science of matrix, effective, curative effect is fast, not easily recurs, and have no side effect, applicable old people takes.

Detailed description of the invention

The invention provides and a kind ofly treat the dizzy pharmaceutical composition of senile deficiency of yang of liver and kidney type, wherein, following raw medicinal material is comprised: Fructus Lycii, Flos Caryophylli, Hepar Caprae seu ovis, Rhizoma Arisaematis, Fructus Akebiae, Herba Pyrolae, Aeschna melanictera, Radix Polygoni Multiflori, Radix Tylophorae arenicolae, Radix cynanchi wilfordii, Rhizoma Polygonati Odorati, Mahonia fortunei (Lindl.) Fedde, Herba Bulbophylli Odoratissim, Mirabilitum, Herba Cynomorii, conjunction tree bacterium, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Chuanxiong, Semen Aesculi, Medulla Junci, Semen Ziziphi Spinosae, Radix Polygalae, Semen Nelumbinis and Radix Rhodiolae Dumulosae.Ingredients scientific matching, reaches the object that the senile deficiency of yang of liver and kidney type for the treatment of is dizzy, has good effect.

The pharmacology of various raw medicinal material is as follows:

Fructus Lycii: [nature and flavor] are sweet is flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." [return through] enters liver, kidney channel.1. " book on Chinese herbal medicine converges and says ": " enter few cloudy, the meridian of Foot-JUE YIN of foot." 2. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, heart channel of Hand-Shaoyin." 3. " key medicine divides agent ": " enters liver, stomach two warp, double enter lung meridian." [function cures mainly] nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.

Flos Caryophylli: [nature and flavor] are pungent, temperature.1. " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." 2. " detailed outline ": " is pungent, heat." [return through] enters stomach, spleen, kidney channel.1. Materia Medica of Decoction: " start with lunar, bright, the shaoyin channel of foot sun." 2. " Thunder God concocts property of medicine solution ": " enters lung, spleen, stomach, kidney four warp." [function cures mainly] warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, tinea disease.1. " property of medicine opinion ": " control cold air stomachache." 2. " Haiyao Bencao, Oversea Materia Medica ": " main air infantile malnutrition is hidden, and bone groove labor is smelly.Control gas, black moustache is sent out, parasite killing, treats five hemorrhoid, wards off evil and uncharms.Control milk headdress flower, only multicolored fulminant dysentery, healthy energy, only cardiac and abdominal pain." 3. " Japan hanako materia medica ": " controls implication, regurgitation, treats kidney qi, sensation of gas rushing, pain over the perineum, tonifying YANG, and warm waist knee joint, kill alcoholism, disappear mass beside the umbilicus, except consumptive disease with cold nature." 4. " Kaibao Bencao ": " warming the spleen stomach, only cholera.(controlling) stops up swollen, and pathogenic wind toxic is all swollen, and tooth infantile malnutrition is hidden." 5. " book on Chinese herbal medicine cover bamboo fish trap ": " only gas make a mistake, QI rising in reverse order." 6. " detailed outline ": " controls the empty sound of vomiting, and vomiting and diarrhea in children, variola insufficiency of stomach is greyish white not to be sent out." 7. " book on Chinese herbal medicine just ": " fast gas of warming middle-JIAO.Control part of the body cavity above the diaphragm housing the heart and lungs singultus, except cold syndrome of the stomach dysentery, seven emotions five are strongly fragrant." 8. " book on Chinese herbal medicine converges ": " treats the thoracic obstruction, pain over the perineum, warm vaginal orifice." 9. " medical center bun want ": " tonifying liver, the profit gate of vitality, warming the stomach, go invasion by pathogenic cold, eliminating the pathogens from the lung, loose rheumatism."

Hepar Caprae seu ovis: [nature and flavor] sweetness and bitterness is cool.1. Tang Materia Medica: " property is cold." 2. " detailed outline ": " is bitter, cold, nontoxic." 3. " occupying diet promise with breath ": " is sweet, cool." [return through] " former machine opens micro-": " enters Liver Channel." [function cures mainly] beneficial blood, tonifying liver, tomorrow.Control blood deficiency and yellow complexion weakness and emaciation, hepatasthenia dim eyesight is dim-sighted, nyctalopia, and optic atrohic blindness is hidden from view.

Rhizoma Arisaematis: [nature and flavor] are bitter, pungent, temperature.[return through] returns lung, liver, spleen channel.[function cures mainly] drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.

Fructus Akebiae: [nature and flavor] are sweet, cold.1. the Meng numerous: " flat." 2. " feeding habits book on Chinese herbal medicine ": " is cold, nontoxic." 3. " Traditional Chinese Medicine in Sichuan will ": " is warm in nature flat, and bitter and puckery flavor is pungent, nontoxic." [function cures mainly] liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp, and uterus drops.1. Cui Yu stannum " cuisine canon ": " going of food light (expectorant) water, only red white lower profit." 2. the Meng numerous: " thick the intestines and stomach, makes us eating, and lower three is burnt, and except bad odor, and son food is better." " leads to the twelve regular channels." 3. supplement to the Herbal: " sharp defecation, Xuan Tong, goes dysphoria with smothery sensation, and making us of food is not lend oneself to worry and anxiety, quenches the thirst, the therapeutic method to keep the adverse QI flowing downwards." 4. " feeding habits book on Chinese herbal medicine ": " main appetite heat-blockage, the not lower food of regurgitation, except three burnt exopathogenic heat." 5. " book on Chinese herbal medicine converges and says ": " cooks it with mulse, controls a mouthful hematodiarrhoea of keeping silent." 6. " Nanjing traditional herbal medicine ": " controls lumbago." 7. " Traditional Chinese Medicine in Sichuan will ": " is soothing the liver, receives kidney qi.Control bladder hernia, spit blood." 8. " pharmacognosy ": " promoting the circulation of QI, invigorates blood circulation, parasite killing, removing toxic substances, pain relieving.For stomachache due to hyperactive liver-QI attacking the stomach, hypochondriac pain, the diseases such as menstrual pain." 9. " Shaanxi Chinese herbal medicine ": " Shugan Yishen, invigorating the spleen and regulating the stomach.

Herba Pyrolae: [nature and flavor] sweetness and bitterness, temperature.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature flat, acrid in the mouth." 2. " Shaanxi Chinese herbal medicine ": " is pained, flat." 3. " Shanxi Chinese herbal medicine ": " is sweet, temperature." [return through] " Zhiwu Mingshi Tukao ": " enters liver, kidney two warp." expelling wind and removing dampness, promoting blood flow to regulate menstruation, controls weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, traumatic hemorrhage for [function cures mainly] tonify deficiency, kidney tonifying.

Aeschna melanictera: [another name] Anax parthenope Selys, green Aeschna melanictera [source] Insecta Odonata dragonfly section Anax parthenope Selys, is used as medicine with dry adult.[habitats distribution] is in all parts of the country.[function cures mainly] the kidney invigorating and essence nourishing, removing toxic substances, cough-relieving.

Radix Polygoni Multiflori: [nature and flavor] are bitter sweet puckery, tepor.1. " Radix Polygoni Multiflori record ": " sweet in the mouth, temperature, nontoxic." 2. " Kaibao Bencao ": " bitter and puckery flavor, tepor, nontoxic." 3. " book on Chinese herbal medicine converges and says ": " raw use gas is trembled with fear, and property is held back, poisonous; Make ripe temperature, nontoxic." [return through] enters liver, kidney channel.1. " detailed outline ": " sufficient the moon of fainting, few the moon." 2. " book on Chinese herbal medicine is through separating ": " enters the Gallbladder Channel of Foot-Shaoyang, triple energizer meridian, heart channel of Hand-Shaoyin, kidney meridian." 3. " book on Chinese herbal medicine is new again ": " enters spleen, lung, kidney three warp." [function cures mainly] tonifying liver, kidney tonifying, nourishes blood, and dispels the wind.

Radix Tylophorae arenicolae: [nature and flavor] are pungent is flat.1. " vegetation is side just ": " pungent, temperature." 2. " Shaanxi Chinese herbal medicine ": " sweet in the mouth is micro-pungent, and property is put down." [function cures mainly] the kidney invigorating, spleen invigorating, removing toxic substances.Control chronic consumptive disease chronic cough, edema, leucorrhea, menoxenia, scrofula, skin ulcer scabies.1. " vegetation is side just ": " tonification reinforcing YIN-essence, removing toxic substances.The labor that cures the wound chronic cough, edema due to deficiency, infections labor, Serpentis, worm, mad dog wound." 2. " classifying herbal ": " pastes son of itching, loose poison, and logical hernia, only nose bleeding, control woman leucorrhea dizzy, is coated with scabies." 3. " conventional glossary of Herbs and Drugs among the people ": " relieves the pain, and detoxification, controls scrofula, stimulating milk secretion, cough-relieving." 4. " Shaanxi Chinese herbal medicine ": " enriching yin and nourishing kidney, invigorating the spleen and benefiting QI, regulating menstruation and activating blood.Control menoxenia, deficiency of YIN leucorrhea."

Radix cynanchi wilfordii: [nature and flavor] are " Kweiyang medicinal herbs among the people " 1.: " sweetness and bitterness, flat, nontoxic." 2. " Shaanxi Chinese herbal medicine ": " Gan Weixin is flat." [function cures mainly] yin nourishing tonify deficiency, strengthening the spleen to promote digestion.Control deficient impairment caused by overstrain, dysentery, infantile malnutrition, have a stomachache glutted, leucorrhea, skin ulcer tinea.

Rhizoma Polygonati Odorati: [nature and flavor] are sweet, flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " WU Pu Bencao ": " legendary god of farming: bitter; Paulownia monarch, Thunder God, Bian Que: sweet, nontoxic; Yellow Emperor, a legendary ruler: pungent." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sweet and slightly bitter taste, the flat tepor of property." 4. " pharmacognosy ": " sweet in the mouth, cold nature." [return through] enters lung, stomach warp.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter spleen." 2. " explaining abstruseness of the canon of materia medica ": " enters kidney." [function cures mainly] yin nourishing, moisturizes, relieving restlessness, quenches the thirst.

Mahonia fortunei (Lindl.) Fedde: [nature and flavor] are bitter, cold.[function cures mainly] leaf: nourishing YIN and clearing away heat.Cure mainly pulmonary tuberculosis, flu.Root, stem: heat-clearing and toxic substances removing.Cure mainly bacillary dysentery, acute smooth gastritis, infectious hepatitis, pneumonia, pulmonary tuberculosis, bronchitis, laryngopharynx swelling and pain.Eye conjunctivitis is controlled in external, carbuncle furuncle and phyma poison, burn.

Herba Bulbophylli Odoratissim: [nature and flavor] are sweet light, cool.1. " Kunming conventional medical herbs among the people ": " taste is micro-sour and astringent, and property is put down." 2. " choosing of Yunnan Chinese herbal medicine ": " is sweet light, cool." [function cures mainly] moistening the lung and resolving phlegm, promoting the circulation of QI to relieve pain.Control pulmonary tuberculosis, spitting of blood, chronic tracheitis, chronic pharyngitis, hernia pain, menoxenia, fracture.1. " Kunming conventional medical herbs among the people ": " wind-damp dispelling, active, circulation of qi promoting, pain relieving." 2. " choosing of Yunnan Chinese herbal medicine ": " synthetism antiinflammatory, moistening the lung and resolving phlegm.Control fracture, pulmonary tuberculosis, spitting of blood, chronic tracheitis, pneumonia convalescent period, chronic pharyngitis, menoxenia." 3. " catalogue planted by Guizhou medicine ": " clearing heat and moistening dryness, promoting the production of body fluid to quench thirst."

Mirabilitum: [nature and flavor] are arduous salty, cold.1. " herbal classic ": " bitter in the mouth, cold." 2. " not Lu ": " be pungent, Great Cold, nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is salty." [return through] enters stomach, large intestine channel.1. " book on Chinese herbal medicine is looked for the truth ": " enter intestinal, stomach, double enter kidney." 2. " book on Chinese herbal medicine brief points ": " starts with, lunar, the Yangming Channel of foot." [function cures mainly] purges heat, and moisturizes, softening the hard mass.Control excess-heat to stagnate, abdominal distention constipation, retention of phlegm gathers, conjunctival congestion and swelling pain, sore throat, carbuncle.

Herba Cynomorii: [nature and flavor] are sweet, temperature.1. amplification on Canon of Materia Medica: " sweet." 2. " detailed outline ": " is sweet, temperature, nontoxic." 3. " book on Chinese herbal medicine is looked for the truth ": " is sweet salty, warm in nature." 4. " Ningxia Chinese herbal medicine handbook ": " is sweet puckery, prevents." [return through] enters liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter kidney channel." 2. " beautiful Chinese catalpa medicine solution ": " enters liver channel of foot-Jueyin." 3. " book on Chinese herbal medicine is looked for the truth ": " enters kidney, large intestine." [function cures mainly] the kidney invigorating intestine moistening.Control sexual impotence, hematuria, blood depletion constipation, waist knee flaccidity.1. " Amplification on Materia Medica addendum ": " nourishing YIN gas.Control void and constipation due to dry stool is used." 2. " detailed outline ": " moisturizes nourishing muscle and tendon.Control flaccidity weak."

Close tree bacterium: [nature and flavor] are sweet; Flat.[function cures mainly] is pleasant; Benefit god; Dispel the wind; Antitumor.Main gastropathy; Leprosy; Tumor.

Herba Lycopodii: [nature and flavor] toil, temperature.1. supplement to the Herbal: " bitter in the mouth is pungent, temperature, nontoxic." 2. " book on Chinese herbal medicine asks former): " sweet puckery, flat." [return through] " Traditional Chinese Medicine in Sichuan will ": " enters liver,spleen,kidney three warp." [function cures mainly] expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation.Control anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, edema, traumatic injury.

Herba speranskiae tuberculatae: [nature and flavor] are " book on Chinese herbal medicine is original " 1.: " sweet in the mouth is nontoxic." 2. " Chinese medicinal herbal ": " is pungent, temperature." [function cures mainly] dispels the wind, and dehumidifying, relaxing muscles and tendons, invigorates blood circulation, pain relieving.Dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness, skin ulcer tinea toxic swelling.

Rhizoma Chuanxiong: [nature and flavor] are pungent, temperature.[return through] returns liver, gallbladder, pericardium channel.[function cures mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.

Semen Aesculi: [nature and flavor] are sweet, temperature.[return through] returns liver, stomach warp.[function cures mainly] regulating the flow of QI to ease the stomach, and stomach and alleviating pain.

Medulla Junci: [nature and flavor] are sweet, light, are slightly cold.[return through] GUIXIN, lung, small intestine meridian.[function cures mainly] clearing away heart-fire, diuresis.For vexed insomnia, the puckery pain of oliguria, aphtha of the mouth and tongue.

Semen Ziziphi Spinosae: [nature and flavor] are sweet is flat.1. " herbal classic ": " sour in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. amplification on Canon of Materia Medica: " tepor." 4. principle of Correct Diet: " sour in the mouth is sweet, flat." [return through] enters the heart, spleen, liver, gallbladder meridian.1. " detailed outline ": " sufficient the moon of fainting, few sun." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen, liver, gallbladder four warp." [function cures mainly] nourishing the liver, mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.

Radix Polygalae: [nature and flavor] are bitter, pungent, warm.[return through] GUIXIN, kidney, lung meridian.[function cures mainly] to be calmed the nerves Fructus Alpiniae Oxyphyllae, is eliminated the phlegm, detumescence.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.

Semen Nelumbinis: [nature and flavor] are sweet, puckery are flat.[return through] returns spleen, kidney, heart channel.[function cures mainly] spleen reinforcing antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.

Radix Rhodiolae Dumulosae: [nature and flavor] sweet puckery micro-hardship, temperature.[function cures mainly] the kidney invigorating, tranquilizing by nourishing the heart, regulating menstruation and activating blood, improving eyesight.Control asthenia, hectic fever due to YIN-deficiency consumptive fever, emaciation due to chronic blood stasis, menoxenia, has a dizzy spell.

The present invention preferably only has above raw medicinal material to obtain.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 oral solutions

Proportioning: Fructus Lycii 10g, Flos Caryophylli 15g, Hepar Caprae seu ovis 8g, Rhizoma Arisaematis 2g, Fructus Akebiae 5g, Herba Pyrolae 10g, Aeschna melanictera 8g, Radix Polygoni Multiflori 8g, Radix Tylophorae arenicolae 5g, Radix cynanchi wilfordii 8g, Rhizoma Polygonati Odorati 10g, Mahonia fortunei (Lindl.) Fedde 12g, Herba Bulbophylli Odoratissim 5g, Mirabilitum 8g, Herba Cynomorii 4g, conjunction tree bacterium 4g, Herba Lycopodii 8g, Herba speranskiae tuberculatae 5g, Rhizoma Chuanxiong 6g, Semen Aesculi 8g, Medulla Junci 6g, Semen Ziziphi Spinosae 8g, Radix Polygalae 6g, Semen Nelumbinis 15g and Radix Rhodiolae Dumulosae 10g.

Its preparation method is:

The first step, Radix Polygoni Multiflori, Radix Tylophorae arenicolae, Radix cynanchi wilfordii and Rhizoma Polygonati Odorati are mixed in proportion, be that the methanol of 75% is as solvent with determining alcohol, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 4 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into powder;

3rd step, adds the distilled water of the powder quality 4 times obtained relative to second step, decocts 3 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 3 times, decoct 1 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 volume, add the ethanol that determining alcohol is 90%, make concentration reach 75%, leave standstill 12 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to powder quality 3 times amount, the sucrose of 0.1 times, the sodium benzoate of 0.01 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral solutions.

Embodiment 2 tablet

Proportioning: Fructus Lycii 20g, Flos Caryophylli 20g, Hepar Caprae seu ovis 13g, Rhizoma Arisaematis 4g, Fructus Akebiae 10g, Herba Pyrolae 15g, Aeschna melanictera 13g, Radix Polygoni Multiflori 13g, Radix Tylophorae arenicolae 10g, Radix cynanchi wilfordii 13g, Rhizoma Polygonati Odorati 15g, Mahonia fortunei (Lindl.) Fedde 20g, Herba Bulbophylli Odoratissim 10g, Mirabilitum 13g, Herba Cynomorii 8g, conjunction tree bacterium 8g, Herba Lycopodii 13g, Herba speranskiae tuberculatae 8g, Rhizoma Chuanxiong 9g, Semen Aesculi 13g, Medulla Junci 12g, Semen Ziziphi Spinosae 12g, Radix Polygalae 10g, Semen Nelumbinis 20g and Radix Rhodiolae Dumulosae 15g.

Its preparation method is:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 350 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.1 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.01 times of magnesium stearate, granulate, tabletting, makes tablet.

Embodiment 3 capsule

Proportioning: Fructus Lycii 15g, Flos Caryophylli 17g, Hepar Caprae seu ovis 10g, Rhizoma Arisaematis 3g, Fructus Akebiae 6g, Herba Pyrolae 12g, Aeschna melanictera 10g, Radix Polygoni Multiflori 10g, Radix Tylophorae arenicolae 8g, Radix cynanchi wilfordii 10g, Rhizoma Polygonati Odorati 12g, Mahonia fortunei (Lindl.) Fedde 17g, Herba Bulbophylli Odoratissim 7g, Mirabilitum 10g, Herba Cynomorii 6g, conjunction tree bacterium 6g, Herba Lycopodii 10g, Herba speranskiae tuberculatae 7g, Rhizoma Chuanxiong 8g, Semen Aesculi 10g, Medulla Junci 8g, Semen Ziziphi Spinosae 10g, Radix Polygalae 8g, Semen Nelumbinis 16g and Radix Rhodiolae Dumulosae 12g.

Its preparation method is:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 350 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.1:0.1, incapsulate in housing, obtain capsule by described capsule 's content.

The toxicity test of medicine

1. acute toxicity test: with the pharmaceutical composition of the embodiment of the present invention 1 for object, gives white mouse large enteral dispensing, observes 7 for 100 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, the present invention does not have toxic action and untoward reaction, and clinical practice is safe and reliable.

2. long term toxicity test: the pharmaceutical composition of the embodiment of the present invention 3 presses 13,30 and 40g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical trial

Case selection: during selecting in February ,-2014 in February, 2013, old people's totally 200 examples that the senile deficiency of yang of liver and kidney type of certain central hospital's diagnosis and treatment is dizzy.Wherein, man 102 example, female 98 example, 50 years old-60 years old age 75 example, 60 years old-70 years old 65 example, 70-75 year 60example.Be divided into four groups at random, often organize 50 people, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group.Four groups of patients comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.

Diagnostic criteria:

1) have a dizzy spell, rotate depending on thing, the lighter closes order and namely stops, and severe one, as ship by bus, very then falls forward.

2) nausea and vomiting can be accompanied, nystagmus, Hiccough and deaf, sweating, pale complexion etc.

3) chronic onset increases the weight of gradually, or Acute onset, or recurrent exerbation.

4) measuring blood pressure, pigment of having a blood test, red blood cell count(RBC) and electrocardiogram, electric audiometry, brainstem evoked potential, electronystagmogram and cervical X-ray take the photograph sheet, and transcranial doppler etc. help clarifies a diagnosis, and has ready conditions and does CT, magnetic resonance examination.

5) should note except tumor, serious blood sick etc.

6) deficiency of yang of liver and kidney type: dizzy of a specified duration endlessly visual deterioration, sleeps forgetful less, vexed xerostomia, tinnitus, god is tired weak, soreness of waist and knee.Red tongue, thin fur, stringy and thready pulse.

Therapeutic Method:

Embodiment 1 group: this group uses the oral solutions of embodiments of the invention 1 to treat.Each oral 5ml, 3 times on the one 5 days is a course for the treatment of, treats 3 courses for the treatment of.

Embodiment 2 groups: this group uses the tablet of embodiments of the invention 2 to treat.Oral 2 at every turn, 3 times on the one 5 days is a course for the treatment of, treats 3 courses for the treatment of.

Embodiment 3 groups: this group uses the capsule of embodiments of the invention 3 to treat.Oral 2 at every turn, 3 times on the one 5 days is a course for the treatment of, treats 3 courses for the treatment of.

Matched group: this group uses betahistine mesylate tablet to treat.Oral: each 1 ~ 2,2 ~ 4 times on the 1st.Intramuscular injection: 12 ~ 4mg, 2 times on the 1st.Within 5 days, be a course for the treatment of, treat 3 courses for the treatment of.

Efficacy evaluation

Cure: symptom, sign and regarding assay room check normal.

Take a turn for the better: symptom and sign alleviate, and lab testing is improved.

Do not heal: symptom is without change.

Therapeutic outcome

Table 1 is the treatment situation contrast of each group

As can be seen from Table 1, the treatment situation of three embodiment groups is better than the therapeutic effect of matched group, it can thus be appreciated that medicine of the present invention, dizzy in the senile deficiency of yang of liver and kidney type for the treatment of, therapeutic effect is good, determined curative effect.

Table 2 is the treatment time contrast of the healing of each group

Group	Healing number	First course for the treatment of	Second course for the treatment of	3rd course for the treatment of
					Embodiment 1 group	50	7（14%）	19（38%）	24（48%）
Embodiment 2 groups	50	8（16%）	21（42%）	21（42%）
					Embodiment 3 groups	50	8（16%）	20（40%）	22（44%）
Matched group	38	2（5.3%）	8（21.1%）	28（73.6%）

As can be seen from Table 2, the healing number that first course for the treatment of of three embodiment groups cures is higher than matched group, it can thus be appreciated that medicine of the present invention, dizzy in the senile deficiency of yang of liver and kidney type for the treatment of, treatment speed is fast, instant effect.

Table 3 is recurrence and side effect contrast (toxic and side effects rate=side effect number/total number of persons, relapse rate=recurrence number/clinical cure number) of each group

Group	Toxic and side effects incidence rate	Relapse rate
			Embodiment 1 group	0（0%）	0（0%）
Embodiment 2 groups	0（0%）	0（0%）
			Embodiment 3 groups	0（0%）	0（0%）
Matched group	3（6%）	1（2.63%）

As can be seen from Table 3, the toxic and side effects of three embodiment groups and recurrence number result are all better than matched group.It can thus be appreciated that Drug therapy of the present invention senile deficiency of yang of liver and kidney type is dizzy, does not have toxic and side effects, does not recur.

Model case: institute of traditional Chinese medicine of Shandong Province accepts a patient of diagnosis and treatment, 60 years old, suffers from deficiency of yang of liver and kidney type dizzy 1 year half.The capsule of embodiments of the invention 3 is used to treat.Oral 2 at every turn, 3 times on the one 5 days is a course for the treatment of, treats 3 courses for the treatment of.In therapeutic process, do not occur other untoward reaction, 3 courses for the treatment of are carried out in treatment, cure.Later stage follows up half a year, does not recur.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (4)

1. treat the dizzy pharmaceutical composition of senile deficiency of yang of liver and kidney type for one kind, it is characterized in that, obtained by the raw medicinal material of following mass fraction: Fructus Lycii 10-20 weight portion, Flos Caryophylli 15-20 weight portion, Hepar Caprae seu ovis 8-13 weight portion, Rhizoma Arisaematis 2-4 weight portion, Fructus Akebiae 5-10 weight portion, Herba Pyrolae 10-15 weight portion, Aeschna melanictera 8-13 weight portion, Radix Polygoni Multiflori 8-13 weight portion, Radix Tylophorae arenicolae 5-10 weight portion, Radix cynanchi wilfordii 8-13 weight portion, Rhizoma Polygonati Odorati 10-15 weight portion, Mahonia fortunei (Lindl.) Fedde 12-20 weight portion, Herba Bulbophylli Odoratissim 5-10 weight portion, Mirabilitum 8-13 weight portion, Herba Cynomorii 4-8 weight portion, close tree bacterium 4-8 weight portion, Herba Lycopodii 8-13 weight portion, Herba speranskiae tuberculatae 5-8 weight portion, Rhizoma Chuanxiong 6-9 weight portion, Semen Aesculi 8-13 weight portion, Medulla Junci 6-12 weight portion, Semen Ziziphi Spinosae 8-12 weight portion, Radix Polygalae 6-10 weight portion, Semen Nelumbinis 15-20 weight portion and Radix Rhodiolae Dumulosae 10-15 weight portion.

2. the pharmaceutical composition that treatment according to claim 1 senile deficiency of yang of liver and kidney type is dizzy, it is characterized in that, the raw medicinal material of following mass fraction is had to obtain: Fructus Lycii 15 weight portion, Flos Caryophylli 17 weight portion, Hepar Caprae seu ovis 10 weight portion, Rhizoma Arisaematis 3 weight portion, Fructus Akebiae 6 weight portion, Herba Pyrolae 12 weight portion, Aeschna melanictera 10 weight portion, Radix Polygoni Multiflori 10 weight portion, Radix Tylophorae arenicolae 8 weight portion, Radix cynanchi wilfordii 10 weight portion, Rhizoma Polygonati Odorati 12 weight portion, Mahonia fortunei (Lindl.) Fedde 17 weight portion, Herba Bulbophylli Odoratissim 7 weight portion, Mirabilitum 10 weight portion, Herba Cynomorii 6 weight portion, close tree bacterium 6 weight portion, Herba Lycopodii 10 weight portion, Herba speranskiae tuberculatae 7 weight portion, Rhizoma Chuanxiong 8 weight portion, Semen Aesculi 10 weight portion, Medulla Junci 8 weight portion, Semen Ziziphi Spinosae 10 weight portion, Radix Polygalae 8 weight portion, Semen Nelumbinis 16 weight portion and Radix Rhodiolae Dumulosae 12 weight portion.

3. the pharmaceutical composition that treatment according to claim 1 and 2 senile deficiency of yang of liver and kidney type is dizzy, it is characterized in that, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes tablet.

4. a preparation method for the pharmaceutical composition that the senile deficiency of yang of liver and kidney of the treatment described in any one of claims 1 to 3 type is dizzy, is characterized in that, comprise the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.05 ~ 0.2:0.05 ~ 0.2, incapsulate in housing, obtain capsule by described capsule 's content.