CN104922542A - Medicine for treating spleen-lung qi deficiency infantile enuresis and preparation method thereof - Google Patents
Medicine for treating spleen-lung qi deficiency infantile enuresis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating spleen-lung qi deficiency infantile enuresis. The medicine comprises white fungus, companumoea roots, the herb of wilson passionflower, American ginseng, coix seeds, the herb of wight parnassia, water chestnut, reeves shad, roots of caragana sinica, dracontomelon duperreanum, fructus aurantii, camphor roots, shepherd's purse, hairyvein agrimony, stephania sinica diels, mentha haplocalyx, rhizoma cibotii, begonia wilsonii, agaric, codonopsis convolvulacea, bloody clam, Korean pine seeds, sugarcane, pork liver, the roots of franchet peashrub flowers, mandarin fish, arrhenatherum elatius, themeda triandra fruits and acanthopanax. The medicine has the effects of reinforcing lung to replenish qi, invigorating spleen and stomach, benefiting qi, nourishing blood and stably securing the exterior, is mainly used for treating spleen-lung qi deficiency infantile enuresis in an internal and external application mode, achieves curing and healing at the same time, is made of pure natural traditional Chinese medicinal materials, attaches great importance to the overall concept, is high in targeting property and effective in treatment, has few adverse effects, can improve overall immunity, control disease in time and reduce complications, and the like.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind ofly treating medicine of deficiency of both the splenic and pulmonary QI type bed-wetting and preparation method thereof.
Background technology
Enuresis (enuresis), also known as nonorganic enuresis or Functional nocturnal enuresis, means that child does not still independently urinate after 5 years old and urinates wet trousers or bed usually, but without obvious organic diseases because of.Enuresis has two kinds of methods of classifying.The first classification be according to the enuresis occur time and determine, (nighttime sleep and afternoon nap is comprised) when child enuresis occurs in sleep, but can control daytime to urinate, and bladder function is normal, then be called the enuresis nocturna of single symptom, and the enuresis is had when children's regains consciousness daytime, but the pathological changes of impassivity system such as spina bifida, spinal injury etc., be then called the daytime enuresis.The second classification method is referred to as constitutional and secondary enuresis, and so-called constitutional refers to that children's has the enuresis from little to time medical always, and Secondary cases refers to that children's once stopped the enuresis at least 6 months, again the enuresis occurs later.
It is reported, primary enuresis is in the great majority, wherein especially the most common with enuresis nocturna, common with boy, enuresis nocturna person about has half to wet the bed every night, even every night the enuresis 2 ~ 3 times, often enuresis increased frequency after excessive daytime activity, excitement, fatigue or physical disease, the enuresis is more rare in the daytime.Enuresis infant usually accompanies fright at night, sleep-walking, many dynamic or other behavior disorders.
Enuresis is not a kind of disease, but a symptom caused by many reasons, its factor occurred comprises heredity, psychology and society factor, sleep state, bladder function capacity etc.
Pathogenesis:
1. inherited genetic factors enuresis child often has family history, the probability of the monodidymus co-morbid of enzygotic twins higher than dizygotic twins person, parents have enuresis person, in offspring, finding that there is enuresis, person reaches 77%; The 1 people person that has enuresis in father and mother, it is 44% that children suffer from enuresis.But, only there is daytime the child of enuresis to seem to have nothing to do with heredity, and all have the child of the enuresis at those daytimes and night, have obvious male's household heredity factors.Shaffer etc. (1984) find that Positive family history is all very common in primary enuresis and secondary enuresis, illustrate that inherited genetic factors plays a part certain.Some researchs of nearest Denmark confirm that the dominant gene of the enuresis is that this genetics research being found to be enuresis provides further evidence on No. 13 chromosome.
2. the epidemiological study of premature labor enuresis confirms, premature labor is child's the most significant high risk factor of the enuresis in the daytime.These premature infants, except having the enuresis, also often with other problem, as attention deficit hyperactivity disorder, have scholar to point out this may be the cause of spared nerve injury.
3. the father and mother of enuresis child of can not awakening from sleep usually report their children have sleep deeply with the phenomenon being difficult to wake up.In fact enuresis nocturna and Depth of sleep have nothing to do, and the enuresis can occur in sleep any stage, and its subject matter is when filling of bladder, and infant can not awakening from sleep.Whether oneself to wake up night the degree that the phenomenon of urinating with or without being reluctant to get up after urinating, whether other people wake up or oneself wake up and wake up in lavatory and determining awakens according to infant clinically.
4. the stressors that psychology and society factor is strong as the bad experience (parental separation, death, child are separated suddenly with father and mother, are due to illness in hospital or contingency) in child's period, just admission be not suitable with new academic environment etc. all can cause child the critical period controlling to urinate because of mental tension the enuresis.Enuresis child also often has more behavior problem and emotional problem, and as how dynamic, twitch, unsocial, shy, temper is eccentric, and it is reported, in enuresis child, about 10% has attention deficit hyperactivity disorder, and boy is more than girl.
5. the bladder capacity of bladder capacity little enuresis child is little compared with the child of the same age without the enuresis.Each urine volume of normal children is about 10ml/kg, and its urine volume of the children's of enuresis does not reach the capacity of due bladder.In general, average each urine volume of these children is less than 10ml/kg, and on frequent micturition on daytime (> 7 times), have urgent micturition phenomenon, evening, enuresis number of times can be more than 1 time, and urine volume can be more or less.
6. constipation enuresis child often has the problem of constipation, the child of the enuresis in the daytime that common is especially, this is because during constipation, sensation is neural consumingly for the excrement block in ampulla of rectum portion, affect brain and causes the enuresis to the perception filled of bladder.
7. the shortage vasopressin of vasopressin raised at night, made child's hypourocrinia in sleep.Have some only enuresis nocturna child because vasopressin lack normal circadian secretion, cause nocturnal urine volume to increase, exceed the capacity of bladder, cause the enuresis.Infant is the enuresis soon after being everlasting and falling asleep, the time generation enuresis of initial 1/3 of generally sleeping at night, and urine stain is large, urinates as the head of a family wakes infant up, then can without enuresis phenomenon.
Enuresis should emphasize comprehensive treatment, and its content comprises:
1. Psychological support and health education 2. urinary function train 3. behavior therapy (1) to put schedule (2) strengthening (3) progressively to postpone the use of nocturnal awakenings time (4) alarm.4. Drug therapy (1) imipramine: this medicine can reduce enuresis nocturna, main mechanism, for alleviating Depth of sleep, makes enuresis child can aware the overflow of bladder.Imipramine unsuitable for children application in less than 6 years old, before within more than 6 years old, child generally sleeps at night, 1h is oral, and dosage range is each 1.0 ~ 1.5mg/kg.Imipramine untoward reaction is giddy, constipation, cardiopalmus, xerostomia and dim eyesight.As overdose, can cause untoward reaction, symptom is tic, ventricular tachycardia and loss of consciousness.This medicine should not be applied in the enuresis child of those home environment instability.In medication process, when the enuresis correct after, medicine should maintain 6 months, then gradually decrement to drug withdrawal.(2) acetic acid removes amine vassopressin: this is a kind of neurohypophyseal hormone of synthesis, be mainly used in the enuresis child because vasopressin lacks, the bladder capacity of these infants is normal, often have night and (or) daytime the enuresis, nocturnal urine volume increases, and urina sanguinis proportion is low, first amount is per os hora somni 0.2mg, as curative effect significantly can not increase to 0.4mg, stopped using after using 3 months continuously at least 1 week, to assess the need of continual cure.Treatments period need be restricted water supply, generally water restriction amount in 1h to 8h after taking medicine before taking medicine.This medicine can cause headache to minority child, feel sick, have a stomachache or epistaxis.
Traditional Chinese medical science motherland medical science thinks that enuresis system deficiency of kidney-QI, bladder can not restrict the event of urine.Syndrome-classification: deficiency of kidney-QI: the middle enuresis of sleeping, urine volume is many, and urine color is clear, sleep soundly, not easily wakes, pale white complexion, lassitude, coldness of the body with chills.Pale tongue, tongue is white, and deep-slow pulse is unable.Deficiency of both the splenic and pulmonary QI: the middle enuresis of sleeping, frequent micturition and measure many, lusterless complexion, spiritlessness and weakness, inappetence, large loose stool is thin.Tongue is partially light, and moderate pulse is thin.Dampness-heat of the liver: the middle enuresis of sleeping, frequent micturition amount is few, irascible temperament, feverish sensation in the palms and soles, red lip and doing.Red tongue, yellow fur, stringy and rolling pulse.
Because doctor trained in Western medicine one side medicine is cured the symptoms, not the disease, fundamentally cannot change the basic disease of bed-wetting, moreover the toxic and side effects of Western medicine is larger, therefore, has bad precipitation toxin impact for children and youth.Compared with doctor trained in Western medicine, Chinese medicine has better effect.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of medicine, has effect of invigorating the lung and benefiting vital QI, foster spleen stomach invigorating, benefiting qi and nourishing blood, steady middle consolidating superficial resistance, cures mainly deficiency of both the splenic and pulmonary QI type bed-wetting.The present invention treats bed-wetting, internal and external application, effects a permanent cure while controlling table, and adopts natural Chinese medicines material, great attention to whole idea, targeting is comparatively strong, and evident in efficacy, untoward reaction is less, can overall immunity be improved, timely symptom management simultaneously, reduce the generation etc. of complication.
For solving the problems of the technologies described above, the invention provides a kind of medicine for the treatment of deficiency of both the splenic and pulmonary QI type bed-wetting, comprise following raw medicinal material: Tremella, Radix Campanumoeae, swallow tail, Radix Panacis Quinquefolii, Semen Coicis, Herba Parnassiae Wightianae, Corm Eleocharitis, Macrura reevesii, Radix Caraganae Sinicae, Fructus Dracontomeli Duperreani, Fructus Aurantii, Radix Cinnamomi Camphorae, Herba Capsellae, Herba Agrimoniae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Menthae Rotundifoliae, Rhizoma Cibotii, Rhizoma Begoniae Willsonii, Auricularia, Radix Codonopsis Convolvulaceae, Carnis Arca inflata, Semen pini koraiensis, Caulis Sacchari sinensis, Hepar Sus domestica, Radix Caraganae Franchetianae, Siniperca chuatsi, the Radix Astragali, Herba avenae fatuae, Herba Themedae japonicae fruit and Radix Et Caulis Acanthopanacis Senticosi.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Tremella 15-25 weight portion, Radix Campanumoeae 10-15 weight portion, swallow tail 5-10 weight portion, Radix Panacis Quinquefolii 4-8 weight portion, Semen Coicis 10-14 weight portion, Herba Parnassiae Wightianae 7-13 weight portion, Corm Eleocharitis 8-14 weight portion, Macrura reevesii 5-9 weight portion, Radix Caraganae Sinicae 8-13 weight portion, Fructus Dracontomeli Duperreani 4-7 weight portion, Fructus Aurantii 10-15 weight portion, Radix Cinnamomi Camphorae 10-20 weight portion, Herba Capsellae 15-20 weight portion, Herba Agrimoniae 6-12 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5-10 weight portion, Herba Menthae Rotundifoliae 15-20 weight portion, Rhizoma Cibotii 4-8 weight portion, Rhizoma Begoniae Willsonii 4-7 weight portion, Auricularia 10-20 weight portion, Radix Codonopsis Convolvulaceae 5-10 weight portion, Carnis Arca inflata 3-6 weight portion, Semen pini koraiensis 10-15 weight portion, Caulis Sacchari sinensis 10-20 weight portion, Hepar Sus domestica 5-10 weight portion, Radix Caraganae Franchetianae 6-10 weight portion, Siniperca chuatsi 5-9 weight portion, Radix Astragali 15-20 weight portion, Herba avenae fatuae 10-20 weight portion, Herba Themedae japonicae fruit 6-15 weight portion and Radix Et Caulis Acanthopanacis Senticosi 15-20 weight portion.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Tremella 15-20 weight portion, Radix Campanumoeae 10-15 weight portion, swallow tail 5-10 weight portion, Radix Panacis Quinquefolii 4-8 weight portion, Semen Coicis 10-14 weight portion, Herba Parnassiae Wightianae 7-10 weight portion, Corm Eleocharitis 8-14 weight portion, Macrura reevesii 5-9 weight portion, Radix Caraganae Sinicae 8-10 weight portion, Fructus Dracontomeli Duperreani 4-7 weight portion, Fructus Aurantii 10-15 weight portion, Radix Cinnamomi Camphorae 15-20 weight portion, Herba Capsellae 15-20 weight portion, Herba Agrimoniae 6-12 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5-10 weight portion, Herba Menthae Rotundifoliae 15-20 weight portion, Rhizoma Cibotii 4-8 weight portion, Rhizoma Begoniae Willsonii 4-7 weight portion, Auricularia 15-20 weight portion, Radix Codonopsis Convolvulaceae 5-10 weight portion, Carnis Arca inflata 3-6 weight portion, Semen pini koraiensis 10-15 weight portion, Caulis Sacchari sinensis 15-20 weight portion, Hepar Sus domestica 5-10 weight portion, Radix Caraganae Franchetianae 6-10 weight portion, Siniperca chuatsi 5-9 weight portion, Radix Astragali 15-20 weight portion, Herba avenae fatuae 10-15 weight portion, Herba Themedae japonicae fruit 6-10 measures part and Radix Et Caulis Acanthopanacis Senticosi 15-20 weight portion.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Tremella 18 weight portion, Radix Campanumoeae 12 weight portion, swallow tail 7 weight portion, Radix Panacis Quinquefolii 5 weight portion, Semen Coicis 12 weight portion, Herba Parnassiae Wightianae 12 weight portion, Corm Eleocharitis 12 weight portion, Macrura reevesii 6 weight portion, Radix Caraganae Sinicae 10 weight portion, Fructus Dracontomeli Duperreani 5 weight portion, Fructus Aurantii 12 weight portion, Radix Cinnamomi Camphorae 15 weight portion, Herba Capsellae 17 weight portion, Herba Agrimoniae 8 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 7 weight portion, Herba Menthae Rotundifoliae 17 weight portion, Rhizoma Cibotii 6 weight portion, Rhizoma Begoniae Willsonii 6 weight portion, Auricularia 16 weight portion, Radix Codonopsis Convolvulaceae 7 weight portion, Carnis Arca inflata 6 weight portion, Semen pini koraiensis 13 weight portion, Caulis Sacchari sinensis 16 weight portion, Hepar Sus domestica 7 weight portion, Radix Caraganae Franchetianae 8 weight portion, Siniperca chuatsi 7 weight portion, the Radix Astragali 17 weight portion, Herba avenae fatuae 13 weight portion, Herba Themedae japonicae fruit 8 weight portions and Radix Et Caulis Acanthopanacis Senticosi 16 weight portion.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Tremella 18 weight portion, Radix Campanumoeae 12 weight portion, swallow tail 6 weight portion, Radix Panacis Quinquefolii 6 weight portion, Semen Coicis 12 weight portion, Herba Parnassiae Wightianae 8 weight portion, Corm Eleocharitis 12 weight portion, Macrura reevesii 6 weight portion, Radix Caraganae Sinicae 9 weight portion, Fructus Dracontomeli Duperreani 5 weight portion, Fructus Aurantii 12 weight portion, Radix Cinnamomi Camphorae 16 weight portion, Herba Capsellae 17 weight portion, Herba Agrimoniae 8 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 6 weight portion, Herba Menthae Rotundifoliae 16 weight portion, Rhizoma Cibotii 6 weight portion, Rhizoma Begoniae Willsonii 6 weight portion, Auricularia 16 weight portion, Radix Codonopsis Convolvulaceae 6 weight portion, Carnis Arca inflata 5 weight portion, Semen pini koraiensis 12 weight portion, Caulis Sacchari sinensis 18 weight portion, Hepar Sus domestica 6 weight portion, Radix Caraganae Franchetianae 7 weight portion, Siniperca chuatsi 6 weight portion, the Radix Astragali 18 weight portion, Herba avenae fatuae 12 weight portion, Herba Themedae japonicae fruit 7 amount parts and Radix Et Caulis Acanthopanacis Senticosi 18 weight portion.
In order to achieve the above object, present invention also offers the preparation method of described medicine, wherein, the dosage form of described medicine is granule, and its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.07 ~ 0.09Mpa, relative density is the mastic of 1.14 ~ 1.17, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
Wherein, the dosage form of described medicine is oral solutions, and its preparation method is:
The first step, Radix Panacis Quinquefolii, Semen Coicis, Herba Parnassiae Wightianae and Corm Eleocharitis are mixed in proportion, be that the methanol of 80% ~ 90% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, pulverized 300-400 order powdered a, the quality of the methanol added is 2 ~ 6 times of first step mixture quality;
Second step, is mixed in proportion surplus stock medical material, pulverizes 300-400 order powdered b;
3rd step, adds the distilled water of the powder b quality 3 ~ 6 times obtained relative to second step, decocts 2 ~ 4 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make concentration reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, drying, obtains and gets dry extract, and pulverizes 300-400 order powdered c;
4th step, mixes powder a and powder c, adds the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stirs, boils, cooling, and filter, subpackage, namely sterilizing obtains oral solutions.
Wherein, the dosage form of described medicine is honey refining pill, and its preparation method is:
Step 1: get crude drug and add 85-95% soak with ethanol 0.5-1.5 hour of 3-5 times amount, heating extraction 1-2 time, each 0.5-1.0 hour, filter to obtain extracting solution and medicinal residues, merge extractive liquid, be the ultrafiltration post ultrafiltration of 38000-84000 again through the molecular weight that dams, ultrafiltration decompression removing ethanol, during simmer down to 85-92 DEG C, relative density is the extractum of 1.03, becomes component 1; Step 2: the medicinal residues that step 1 obtains add 2-3 times amount water soaking 1.0-2.0 hour, extracts 1 time, is the extractum of 1.1, as component 2 by relative density during extracting solution heating under reduced pressure simmer down to 80-90 DEG C for 1.0-1.5 hour; Step 4: component 1, component 2 are mixed, adds and is twisted into honey refining pill relative to the Mel of mixture 2 times amount.
Wherein, the dosage form of described medicine is: tablet, film coated tablet, sugar coated tablet, soft capsule drop, suck agent, granule, enteric coated tablet, electuary, honey pill agent, oral liquid, solution, sublimed preparation, suppository, syrup, injection, powder, liniment, spray, drop, patch and liniment.
The invention has the beneficial effects as follows: the present invention has effect of invigorating the lung and benefiting vital QI, foster spleen stomach invigorating, benefiting qi and nourishing blood, steady middle consolidating superficial resistance, cures mainly deficiency of both the splenic and pulmonary QI type bed-wetting.The present invention treats bed-wetting, internal and external application, effects a permanent cure while controlling table, and adopts natural Chinese medicines material, great attention to whole idea, targeting is comparatively strong, and evident in efficacy, untoward reaction is less, can overall immunity be improved, timely symptom management simultaneously, reduce the generation etc. of complication.
Detailed description of the invention
The present invention treats deficiency of both the splenic and pulmonary QI type bed-wetting, there is effect of invigorating the lung and benefiting vital QI, foster spleen stomach invigorating, benefiting qi and nourishing blood, steady middle consolidating superficial resistance, select following raw medicinal material: Tremella, Radix Campanumoeae, swallow tail, Radix Panacis Quinquefolii, Semen Coicis, Herba Parnassiae Wightianae, Corm Eleocharitis, Macrura reevesii, Radix Caraganae Sinicae, Fructus Dracontomeli Duperreani, Fructus Aurantii, Radix Cinnamomi Camphorae, Herba Capsellae, Herba Agrimoniae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Menthae Rotundifoliae, Rhizoma Cibotii, Rhizoma Begoniae Willsonii, Auricularia, Radix Codonopsis Convolvulaceae, Carnis Arca inflata, Semen pini koraiensis, Caulis Sacchari sinensis, Hepar Sus domestica, Radix Caraganae Franchetianae, Siniperca chuatsi, the Radix Astragali, Herba avenae fatuae, Herba Themedae japonicae fruit and Radix Et Caulis Acanthopanacis Senticosi.
Wherein, Tremella, Radix Campanumoeae, swallow tail, Radix Panacis Quinquefolii, Semen Coicis, Herba Parnassiae Wightianae, Corm Eleocharitis, Macrura reevesii invigorating the lung and benefiting vital QI; Radix Caraganae Sinicae, Fructus Dracontomeli Duperreani, Fructus Aurantii, Radix Cinnamomi Camphorae, Herba Capsellae, Herba Agrimoniae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Menthae Rotundifoliae support spleen stomach invigorating; Rhizoma Cibotii, Rhizoma Begoniae Willsonii, Auricularia, Radix Codonopsis Convolvulaceae, Carnis Arca inflata, Semen pini koraiensis, Caulis Sacchari sinensis, Hepar Sus domestica, Radix Caraganae Franchetianae, Siniperca chuatsi benefiting qi and nourishing blood; The Radix Astragali, Herba avenae fatuae, Herba Themedae japonicae fruit, the steady middle consolidating superficial resistance of Radix Et Caulis Acanthopanacis Senticosi.
The pharmacology of each raw medicinal material is as follows:
Tremella: [nature and flavor] are sweet is flat.[function cures mainly] invigorating the lung and benefiting vital QI, nourishing YIN to relieve dryness.For body is empty after being ill, chronic cough of deficiency lung, sputum mixed with blood, metrorrhagia, constipation, hypertension, sclerosis of blood vessels.
Radix Campanumoeae: [nature and flavor] are sweet is flat.[function cures mainly] invigorating the spleen and replenishing QI, the lung moistening and production of body fluid promoting.Weak for the deficiency of vital energy, insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, infantile malnutrition, milk is rare.
Swallow tail: [nature and flavor] are bitter, micro-sweet, temperature.[function cures mainly] invigorating the lung and benefiting vital QI, antiinflammatory, sterilization.Cure mainly dysentery, pulmonary tuberculosis, bronchitis.Drop into manure pit sump and kill maggot, wriggler.
Radix Panacis Quinquefolii: [nature and flavor] sweet micro-hardship is cool.1. " Bencao Congxin ": " bitter micro-sweet, cold." 2. " book on Chinese herbal medicine is new again ": " sweet in the mouth is pungent, cool in nature, nontoxic." [return through] " book on Chinese herbal medicine is new again ": " enters the heart, lung, kidney three warp." [function cures mainly] lung benefiting is cloudy, clear asthenic fire, promoting the production of body fluid to quench thirst.Control deficiency of the lung chronic cough, lose blood, dry throat and mouth, deficiency-heat is tired of tired.1. " Bencao Congxin ": " tonifying the lung pathogenic fire reducing, born fluid, relieving restlessness is tired.Empty and have fiery person suitable." 2. " property of medicine is examined ": " nourishing YIN is brought down a fever.Processed with Rhizoma Zingiberis Recens QI invigorating, righting gas.It is prosperous that " 3. " book on Chinese herbal medicine is new again ": " controls lung-fire, and cough with copious phlegm, the deficiency of vital energy breathes out to breathe heavily, and loses blood, impairment caused by overstrain, and controlling nocturnal emission with astringent drugs is calmed the nerves, and produces all void." 4. " book on Chinese herbal medicine asks former ": " lung heat clearing kidney, cool heart spleen, with pathogenic fire reducing, is relieved summer heat, is relieved the effect of alcohol." 8. " Records of Tradition Chinese and Western Medicine in Combination ": " can subsidize edema caused by disorder of QI, and can tonification blood system."
Semen Coicis: [nature and flavor] are sweet, light, cool.[return through] returns spleen, stomach, lung meridian.[function cures mainly] spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Herba Parnassiae Wightianae: [nature and flavor] are sweet, temperature.1. " Kweiyang medicinal herbs among the people ": " Xin Gan, temperature, nontoxic." 2. " Traditional Chinese Medicine in Sichuan will ": " is warm in nature.Lightly seasoned, nontoxic." [function cures mainly] is controlled cough and is spitted blood, traumatic injury, leucorrhea, eczema.1. " Kweiyang medicinal herbs among the people ": " tonifying the lung and stopping cough.Control women leucorrhea, traumatic injury." 2. " Traditional Chinese Medicine in Sichuan will ": " tonify deficiency QI invigorating, diuretic dehumidifies.Control women leucorrhea.Cough is spitted blood and damp and hot sore."
Corm Eleocharitis: [nature and flavor] are sweet, cold.1. " not Lu ": " bitter but sweet flavor, is slightly cold, nontoxic." 2. " detailed outline ": " is sweet, and be slightly cold cunning, nontoxic." 3. " medical center bun is wanted ": " is sweet salty, cold sliding." 4. " book on Chinese herbal medicine asks former ": " slightly sweet flavor, cold in nature, nontoxic." [return through] enters lung, stomach warp.1. " beautiful Chinese catalpa medicine solution): " enter spleen of Foot-Taiyin, liver channel of foot-Jueyin." 2. " must join book on Chinese herbal medicine ": " enters Foot yangming Channel." 3. " book on Chinese herbal medicine is looked for the truth ": " enters liver, stomach, large intestine." 4. " book on Chinese herbal medicine is new again ": " enters the heart, liver, lung three warp." [function cures mainly] heat clearing away, reduces phlegm, removing food stagnancy.Control angry disease to quench one's thirst, jaundice, pyretic stranguria, mass in the abdomen, conjunctival congestion, chew larynx and swell and ache, wart.1. " not Lu ": " mainly quench one's thirst, numbness heat, hankers, QI invigorating." 2. the Meng numerous: " pathogenic wind expelling poison, except stagnancy of pathogens in chest steam; Can make powder food, improve visual and auditory acuity, quenches the thirst, the subcutaneous ulcer that disappears Huang." 3. " Japan hanako materia medica ": " whetting the appetite." 4. " daily book on Chinese herbal medicine ": " lower five types of stranguria, rushes down gastric heat." 5. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls heat in the abdomen expectorant, large intestine hematochezia." 6. " book on Chinese herbal medicine compilation ": " treats five kinds of diaphragm gas, and disappear dyspepsia, should eat it after meal." 7. " detailed outline ": " main dysentery, hematochezia, metrorrhagia.It is damp and hot that " 8. " herbal classic is met former ": " controls drinker lung stomach, and sound is unclear." 9. " northern inkstone food rule ": " water chestnut starch: clear away heart-fire, open nebula." 10. " book on Chinese herbal medicine is new again ": " clearing heart fire, the cool liver of tonifying the lung, eliminate indigestion and phlegm, removing mass is stagnant, sharp store blood."
Macrura reevesii: [nature and flavor] sweet in the mouth; Property is put down.[return through] spleen; Lung meridian.[function cures mainly] strengthening the spleen and tonifying the lung; Line water detumescence.Main asthenia; Chronic cough; Edema.
Radix Caraganae Sinicae: nature and flavor toil is flat.1. " vegetation is side just ": " bitter." 2. " classifying herbal ": ' is lightly seasoned." 3. " Fujian traditional herbal medicine ": " toil, tepor." 4. " Traditional Chinese Medicine in Sichuan will ": " property is put down, and sweet in the mouth is micro-pungent, nontoxic." [return through] " Traditional Chinese Medicine in Sichuan will ": " enters lung, spleen two warp." [function cures mainly] lung heat clearing strengthening the spleen, blood circulation and channel invigorating.Control deficient consumptive fever, cough, hypertension, women leucorrhea, metrorrhagia, arthragra, traumatic injury.1. " detailed outline is picked up any lost article from the road ": " control traumatic injury, cough.Warm muscles and bones, treat gout, performance chases after wind and invigorates blood circulation, promoting blood circulation of holding concurrently, and disappear knot poison." 2. " Zhiwu Mingshi Tukao ": " removes the peel, and boils Cor Sus domestica, except consumptive disease disease." " mends muscles and bones." 3. " Kaibao Bencao ": " lung heat clearing strengthening the spleen.Control dizziness, cough, asthma, infirmities and diseases, epistaxis." 4. " Guizhou side's medicine among the people collection ": " stimulates the menstrual flow, diuresis.Control pouring disease, leucorrhea.Again can lactogenic." 5. " Traditional Chinese Medicine in Sichuan will ": " strengthening the spleen and stomach.Control deficient consumptive fever, the diseases such as prolapse of the uterus."
Fructus Dracontomeli Duperreani: [nature and flavor] acid is cool.[function cures mainly] strengthening the spleen to promote digestion, promoting the production of body fluid to quench thirst.Cure mainly dyspepsia, inappetence, calentura is thirsty.Rotten skin ulcer is controlled in external, decubital ulcer.
Fructus Aurantii: [nature and flavor] toil is cool.1. Lei Gong's Treatise on Preparation and Broiling of Materia Medica: " arduous.The acid of " 2. " Kaibao Bencao ": " bitter in the mouth, is slightly cold, nontoxic." 3. " medicine origin ": " gas is trembled with fear, bitter in the mouth." [return through] enters lung, spleen, large intestine channel.1. " Thunder God concocts property of medicine solution ": " enter lung, liver, stomach, large intestine four warp." 2. " medicineization justice ": " enters lung, spleen, stomach, large intestine four warp." [function cures mainly] dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.1. " property of medicine opinion ": " control rubella all over, dislike and itch, main hemorrhoidal hamorrhage haemorrhoids, stagnation of QI in chest and abdomen in flesh as numb bean, the swollen void of two sides of body, pass diaphragm is congested." 2. " Japan hanako materia medica ": " spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.Control regurgitation, cholera dysentery, helps digestion, and broken crux mass beside the umbilicus, five types of dysphagia, except wind improving eyesight and lung qi edema, sharp intestine and small intestine, skin is itched.Swollen can the processing of hemorrhoid is pressed."
Radix Cinnamomi Camphorae: [nature and flavor] 1. " classify herbal ": " pungent, nontoxic." 2. " Kweiyang medicinal herbs among the people ": " is pungent, temperature, nontoxic." [return through] " Traditional Chinese Medicine in Sichuan will ": " enters liver, spleen two warp." [function cures mainly] vital energy regualting and blood circulation-promoting, except rheumatism.Control vomiting and dirarrhea, trusted subordinate's distending pain, rheumatic arthralgia, traumatic injury, scabies pruritus.1. " classify herbal ": " control all pain due to disorder of QI, reason numbness, pleasant, and cholera vomiting." 2. " Guizhou side's medicine among the people collection ": " dispelling the wind and dampness pathogens pain, traumatic injury." 3. " Kweiyang medicinal herbs among the people ": " regulates the flow of vital energy, promoting the circulation of blood, stomach invigorating.Control gastropathy, bones and muscles pain, bromhidrosis, sweaty foot."
Herba Capsellae: nature and flavor are sweet is flat.1. " not Lu ": " sweet in the mouth, temperature, nontoxic." 2. " a thousand pieces of gold dietetic therapy ": " sweet-puckery flavor, temperature, nontoxic." 3. " daily book on Chinese herbal medicine ": " acrid-sweet flavor is cool flat." [return through] 1. " must join book on Chinese herbal medicine ": " enters meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine brief points ": " few the moon of starting with, lunar, meridian of Foot-JUE YIN." [function cures mainly] and spleen, diuretic, hemostasis, improving eyesight.Control dysentery, edema, gonorrhea, chyluria, spit blood, have blood in stool, metrorrhagia, menorrhagia, conjunctival congestion and pain of eye.
Herba Agrimoniae: [nature and flavor] toil is flat.1. 《 Lv Cliff rock book on Chinese herbal medicine ": " acrid in the mouth is puckery, temperature, nontoxic." 2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " slightly warm in nature, bitter and puckery flavor." 3. " the SHENGCAO property of medicine is standby to be wanted ": " taste is sweet, and property is put down." [return through] enters lung, liver, spleen channel.[function cures mainly] stops blooding, stomach invigorating.Control spitting of blood, spit blood, hematuria, has blood in stool, dysentery, bleeding not during menses, and impairment caused by overstrain takes off power, carbuncle, traumatic injury, wound hemorrhage.
Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae): [nature and flavor] Guangzhou army " conventional Chinese herbal medicine handbook ": " bitter, cold." [function cures mainly] heat-clearing and toxic substances removing, benefiting stomach and stopping pain, dissipating blood stasis for subsidence of swelling.Control exogenous cough, pharyngalgia, aphtha of the mouth and tongue, vomiting and diarrhoea, dysentery, stomachache, swollen ulcer drug, traumatic injury.
Herba Menthae Rotundifoliae: [nature and flavor] " Chongqing medical herbs ": " acrid in the mouth, cool in nature, nontoxic." [function cures mainly] falls apart wind heat, detumescence poison.Control Common Cold, peratodynia, epistaxis, conjunctival congestion, furuncle furuncle.1. " classify herbal ": " remove wind, improving eyesight, loose expectorant, clearing heat in QI system." 2. " Traditional Chinese Medicine in Sichuan will ": " stomach invigorating emesis.Control peratodynia; External is coated with foot life and chaps." 3. " catalogue planted by Guizhou medicine ": " wind dispelling, heat radiation, hemostasis, detumescence poison.Control black furuncle, eye red, relapsing fever, nose is hidden, total numbness, children's's furuncle, nose bleeding, Common Cold."
Rhizoma Cibotii: [nature and flavor] are bitter sweet, temperature.1. " herbal classic ": " bitter in the mouth is flat." 2. " WU Pu Bencao ": " paulownia monarch, Yellow Emperor, a legendary ruler, qi primary, Thunder God, Bian Que: sweet, nontoxic.Li Shi: temperature." 3. " property of medicine opinion "; " bitter in the mouth is pungent, slight fever." [return through] enters liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter kidney, bladder two warp." 2. " book on Chinese herbal medicine is looked for the truth ": " enters liver, kidney." 3. " book on Chinese herbal medicine is new again ": " enters the heart, liver, kidney three warp." [function cures mainly] invigorating the liver and kidney, except rheumatism, strong waist foot, sharp joint.Control back ache, gonalgia flaccidity of the lower limbs, cold-damp general arthralgia, lose and drown, frequent micturition, seminal emission, leucorrhea.1. " herbal classic ": " main back is strong, machine-operated emergency, general arthralgia cold-damp, gonalgia.Quite sharp old man." 2. " not Lu ": " treats that losing drowns does not save, and man's flaccidity of the lower limbs lumbago, ailment said due to cold or exposure drenches dew, weak breath order Dark, hard ridge, sharp pitching, woman's damaging the spleen and stomach, and joint is heavy." 3. " property of medicine opinion ": " controls man woman poison wind weak foot, and pathogen arthralgia chiefly caused by damp pathogen, kidney qi is weak, tonification man, stricture of vagina muscles and bones." 4. " detailed outline ": " strong Liver and kidney, strong bone, controls wind void." 5. " beautiful Chinese catalpa medicine solution ": " lets out wet cold removing, plays flaccidity pain relieving, lets out kidney liver dampness, consciousness restoring, bone and muscle strengthening, controls lumbago knee joint pain, and the swollen lower limb of foot is weak, seminal emission foul leukorrhea." 6. " detailed outline is picked up any lost article from the road ": " golden Rhizoma Cibotii only all skin ulcer blood goes out, and control insensitive impediment, black person parasite killing is more imitated." 7. " book on Chinese herbal medicine is new again ": " hard kidney nourishes blood, QI invigorating."
Rhizoma Begoniae Willsonii: [nature and flavor] are sweet, bitter is flat.[function cures mainly] air making-up and spleen enlivening, nourishes blood, stops blooding.Weak after being ill, cough spitting of blood, dysfunctional uterine hemorrhage, leucorrhea.
Auricularia: [nature and flavor] are sweet, flat.[function cures mainly] fills blood, lung moistening, hemostasis.For Qi and blood deficiency, extremity are twitched, cough due to deficiency of the lung, spitting of blood, spit blood, epistaxis, metrorrhagia, hypertension, constipation.
Radix Codonopsis Convolvulaceae: [nature and flavor] sweet, micro-hardship, tepor.[function cures mainly] invigorating QI and blood, the lung moistening and production of body fluid promoting.For anemia, spontaneous perspiration, deficiency of lung-YIN is coughed, neurasthenia.
Carnis Arca inflata: [nature and flavor] are sweet, temperature.1. " not Lu ": " hide sweet, flat, nontoxic." 2. " food furuncle book on Chinese herbal medicine ": " is cold." 3. " product remittance essence is wanted ": " salty in the mouth, warm in nature, nontoxic." [function cures mainly] enriches blood, warming middle-JIAO, stomach invigorating.Control blood deficiency scabies numbness, stomachache, dyspepsia, dysentery pus and blood.1. " not Lu ": " main scabies numbness lets out dysentery, passing stool with blood and pus." 2. " Treatise on Dietetic Therapy ": " moistening five ZANG-organs, controls and quenches one's thirst, joint." 3. supplement to the Herbal: " controls trusted subordinate's cold air, spinal column cold wind, sharp the five internal organs, stomach invigorating." 4. " four tones of standard Chinese pronunciation book on Chinese herbal medicine ": " warming middle-JIAO helps digestion, and plays sun." 5. " Japan hanako materia medica ": " beneficial color." 6. " medical center bun is wanted ": " reinforcing the heart blood, dissipating blood stasis blood, relieving restlessness relieving alcoholic intoxication, the expectorant of broken knot."
Semen pini koraiensis: [nature and flavor] are sweet, temperature.1. " Haiyao Bencao, Oversea Materia Medica ": " sweet in the mouth, temperature, nontoxic greatly." 2. " Kaibao Bencao ": " sweet in the mouth, little temperature, nontoxic." 3. " beautiful Chinese catalpa medicine solution ": " sweet in the mouth is pungent, and gas is put down." [return through] enters liver, lung, large intestine channel.1. " beautiful Chinese catalpa medicine solution ": " enter spleen of Foot-Taiyin, the bright large intestine of hands sun, the few cloudy heart of hands, liver channel of foot-Jueyin." 2. " key medicine divides agent ": " enters lung, large intestine channel." [function cures mainly] nutrient solution, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., lung moistening, and laxation, controls migratory arthralgia, dizziness, cough caused by dryness, spits blood, constipation.1. " Haiyao Bencao, Oversea Materia Medica ": " main all wind, warming intestines and stomach." 2. " Japan hanako materia medica ": ", by migratory arthralgia cold, weakness with emaciation weak breath, tonifying for the deficiency, moistens skin, fertile the five internal organs." 3. " Kaibao Bencao ": " main joint wind, dizziness, removes dead flesh, bleaches, aproll gas, and moistening five ZANG-organs is not hungry." 4. amplification on Canon of Materia Medica: " and Semen Platycladi are ruled together constipation due to insufficiency." 5. " detailed outline ": " lung moistening, controls dryness accumulated in the stomach and intestine cough." 6. " explaining abstruseness of the canon of materia medica ": " lung benefiting antitussive, benefiting qi and nourishing blood, intestine moistening is quenched the thirst, and warming middle-JIAO searches wind." 7. " book on Chinese herbal medicine is new again ": " lung moistening spleen invigorating, holds back cough, emesis blood."
Caulis Sacchari sinensis: [nature and flavor] are sweet, cold.1. " not Lu ": " sweet, flat, nontoxic." 2. " Japan hanako materia medica ": " is cold." 3. " this sketch of the southern regions of the Yunnan Province is said ": " abnormal smells from the patient is sweet, and cold nature is nontoxic." 4. " detailed outline ": " is sweet puckery, flat, nontoxic." [return through] enters lung, stomach warp.1. " Bencao Jingshu ": " start with, foot lunar, Foot yangming Channel." 2. " book on Chinese herbal medicine is newly organized ": " enters spleen, lung, intestine and small intestine." 3. " book on Chinese herbal medicine is new again ": " enters liver, spleen two warp." [function cures mainly] disappears heat, and promote the production of body fluid, the therapeutic method to keep the adverse QI flowing downwards, moisturizes.Control calentura Tianjin wound, restlessness and thirst, regurgitation is vomitted, xeropulmonary cough, constipation due to dry stool.And alcoholic intoxication.1. " not Lu ": " the main therapeutic method to keep the adverse QI flowing downwards and in, help taste, sharp large intestine." 2. " Treatise on Dietetic Therapy ": " main QI invigorating, the therapeutic method to keep the adverse QI flowing downwards of holding concurrently." 3. " Japan hanako materia medica ": " sharp intestine and small intestine, lower diarrhea due to disorder of qi, spleen reinforcing, expectorant is quenched the thirst, except vexed heat."
Hepar Sus domestica: [nature and flavor] sweetness and bitterness, temperature.1. " a thousand pieces of gold dietetic therapy "; " bitter, flat, nontoxic." 2. " Bencao Tujing ": " temperature." 3. " occupying diet spectrum with breath ": " sweetness and bitterness, temperature." [return through] " detailed outline ": " enters liver." [function cures mainly] tonifying liver, nourishes blood, improving eyesight.Control blood deficiency and yellow complexion, nyctalopia, conjunctival congestion, edema, beriberi.1. " a thousand pieces of gold dietetic therapy ": " main improving eyesight." 2. supplement to the Herbal: " main beriberi.Hollow, cut and give birth to, enter it with Rhizoma Zingiberis Recens vinegar, let out when micro-.If first dysentery, does not namely take." 3. " dietitian's heart mirror ": " flatulence of harnessing the river is full, edema." 4. " herbal classic is met former ": " controls proctoptosis." 5. " book on Chinese herbal medicine is new again ": " treating the liver wind."
Radix Caraganae Franchetianae: [nature and flavor] property is put down, sweet and slightly bitter taste.[function cures mainly] expelling wind and activating blood circulation, pain relieving, diuresis, QI invigorating kidney tonifying.Treating rheumatic arthritis, traumatic injury, galactopoiesis is not enough, edema, dysmenorrhea.
Siniperca chuatsi: [nature and flavor] are sweet, flat.1. " Treatise on Dietetic Therapy ": " flat, slightly poison." 2. " Kaibao Bencao ": " sweet in the mouth is flat, nontoxic." [return through] " book on Chinese herbal medicine is looked for the truth ": " enters spleen, stomach." [function cures mainly] fills blood, strengthening the spleen stomach.Control asthenia weakness and emaciation, hemorrhoidal hamorrhage rushes down blood.1. " Treatise on Dietetic Therapy ": " mend labor, strengthening the spleen stomach." 2. " Japan hanako materia medica ": " QI invigorating, controls hemorrhoidal hamorrhage and rushes down blood.Stagnant blood in " 3. " Kaibao Bencao ": " main abdomen, physical strength profiting, makes us fertile strong, goes small worm in abdomen." 4. " occupying diet spectrum with breath ": " nourishes blood, and tonify deficiency labor, kills labor worm, and disappear stagnant blood, fortune diet."
The Radix Astragali: [nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Herba avenae fatuae: [nature and flavor] are sweet is flat.[function cures mainly] astringing to arrest bleeding, strengthening superficial resistance to stop perspiration.For spitting blood, metrorrhagia, leucorrhea, has blood in stool, spontaneous perspiration, night sweat.
Herba Themedae japonicae fruit: [nature and flavor] sweet in the mouth; Property is put down.[function cures mainly] consolidating superficial resistance arresting sweating.Main night sweat.
Radix Et Caulis Acanthopanacis Senticosi: [nature and flavor] pungent, micro-hardship, temperature.[return through] returns spleen, kidney, heart channel.[function cures mainly] replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Described medicine is preferably only obtained by above-mentioned medical material.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 granule
Formula: 16 parts, Tremella, Radix Campanumoeae 12 parts, 6 parts, swallow tail, Radix Panacis Quinquefolii 5 parts, Semen Coicis 12 parts, Herba Parnassiae Wightianae 12 parts, Corm Eleocharitis 9 parts, Macrura reevesii 6 parts, Radix Caraganae Sinicae 12 parts, Fructus Dracontomeli Duperreani 6 parts, Fructus Aurantii 12 parts, Radix Cinnamomi Camphorae 12 parts, 16 parts, Herba Capsellae, Herba Agrimoniae 8 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 7 parts, Herba Menthae Rotundifoliae 17 parts, Rhizoma Cibotii 7 parts, Rhizoma Begoniae Willsonii 5 parts, 12 parts, Auricularia, Radix Codonopsis Convolvulaceae 6 parts, Carnis Arca inflata 6 parts, Semen pini koraiensis 12 parts, Caulis Sacchari sinensis 15 parts, 6 parts, Hepar Sus domestica, Radix Caraganae Franchetianae 7 parts, Siniperca chuatsi 6 parts, the Radix Astragali 16 parts, Herba avenae fatuae 12 parts, Herba Themedae japonicae fruit 8 parts and Radix Et Caulis Acanthopanacis Senticosi 17 parts.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 times, mixture is the ethanol of 85%, be heated to boiling reflux 3 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.15, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.2 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.
Embodiment 2 oral solutions
Formula: 18 parts, Tremella, Radix Campanumoeae 12 parts, 7 parts, swallow tail, Radix Panacis Quinquefolii 5 parts, Semen Coicis 12 parts, Herba Parnassiae Wightianae 12 parts, Corm Eleocharitis 12 parts, Macrura reevesii 6 parts, Radix Caraganae Sinicae 10 parts, Fructus Dracontomeli Duperreani 5 parts, Fructus Aurantii 12 parts, Radix Cinnamomi Camphorae 15 parts, 17 parts, Herba Capsellae, Herba Agrimoniae 8 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 7 parts, Herba Menthae Rotundifoliae 17 parts, Rhizoma Cibotii 6 parts, Rhizoma Begoniae Willsonii 6 parts, 16 parts, Auricularia, Radix Codonopsis Convolvulaceae 7 parts, Carnis Arca inflata 6 parts, Semen pini koraiensis 13 parts, Caulis Sacchari sinensis 16 parts, 7 parts, Hepar Sus domestica, Radix Caraganae Franchetianae 8 parts, Siniperca chuatsi 7 parts, the Radix Astragali 17 parts, Herba avenae fatuae 13 parts, Herba Themedae japonicae fruit 8 parts and Radix Et Caulis Acanthopanacis Senticosi 16 parts.
Its preparation method comprises the following steps:
The first step, Radix Panacis Quinquefolii, Semen Coicis, Herba Parnassiae Wightianae and Corm Eleocharitis are mixed in proportion, be that the methanol of 85% is as solvent with determining alcohol, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, pulverized 350 order powdered a, the quality of the methanol added is 4 times of first step mixture quality;
Second step, is mixed in proportion surplus stock medical material, pulverizes 350 order powdered b;
3rd step, adds the distilled water of the powder b quality 5 times obtained relative to second step, decocts 3 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 3 times, decoct 2 hours, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 volume, add the ethanol that determining alcohol is 90%, make concentration reach 80%, leave standstill 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, pulverized 350 order powdered c;
4th step, mixes powder a and powder c, adds the distilled water relative to powder quality 4 times amount, the sucrose of 0.3 times, the sodium benzoate of 0.01 times, stirs, boils, cooling, and filter, subpackage, namely sterilizing obtains oral solutions.
Embodiment 3 honey refining pill
Formula: 18 parts, Tremella, Radix Campanumoeae 12 parts, 6 parts, swallow tail, Radix Panacis Quinquefolii 6 parts, Semen Coicis 12 parts, Herba Parnassiae Wightianae 8 parts, Corm Eleocharitis 12 parts, Macrura reevesii 6 parts, Radix Caraganae Sinicae 9 parts, Fructus Dracontomeli Duperreani 5 parts, Fructus Aurantii 12 parts, Radix Cinnamomi Camphorae 16 parts, 17 parts, Herba Capsellae, Herba Agrimoniae 8 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 6 parts, Herba Menthae Rotundifoliae 16 parts, Rhizoma Cibotii 6 parts, Rhizoma Begoniae Willsonii 6 parts, 16 parts, Auricularia, Radix Codonopsis Convolvulaceae 6 parts, Carnis Arca inflata 5 parts, Semen pini koraiensis 12 parts, Caulis Sacchari sinensis 18 parts, 6 parts, Hepar Sus domestica, Radix Caraganae Franchetianae 7 parts, Siniperca chuatsi 6 parts, the Radix Astragali 18 parts, Herba avenae fatuae 12 parts, Herba Themedae japonicae fruit 7 amount parts and Radix Et Caulis Acanthopanacis Senticosi 18 parts.
Its preparation method comprises the following steps:
Step 1: get 85% soak with ethanol 0.5 hour, heating extraction 2 times that crude drug adds 4 times amount, each 1.0 hours, filter to obtain extracting solution and medicinal residues, merge extractive liquid, be the ultrafiltration post ultrafiltration of 38000-84000 again through the molecular weight that dams, ultrafiltration decompression removing ethanol, during simmer down to 92 DEG C, relative density is the extractum of 1.03, becomes component 1; Step 2: the medicinal residues that step 1 obtains add 3 times amount water soaking 2.0 hours, extracts 1 time, is the extractum of 1.1, as component 2 by relative density during extracting solution heating under reduced pressure simmer down to 90 DEG C for 1.5 hours; Step 4: component 1, component 2 are mixed, adds and is twisted into honey refining pill relative to the Mel of mixture 2 times amount.
Toxicity test
1. acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 1 is dissolved in water, (concentration is 8g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 40g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>40g crude drug/kg of the present invention, every day, maximum dosage-feeding was 80g crude drug/kg/ day.Clinical drug dosage of the present invention be 5g crude drug/day/people, adult body weight in 60KG, average dosage is 0.083g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage medicine of the present invention is 964 times of quantity.Therefore drug anesthesia Acute toxicity of the present invention is low, clinical drug safety.
2. cumulative toxicity test: test method: select 20 healthy mices, female, each 10 of hero, with the oral solutions of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Medicine of the present invention is described, does not there is cumulative toxicity.
Clinical trial
Case selection: during selecting in March ,-2013 in March, 2012, affected children ranges totally 200 examples of the qi-deficiency of spleen and stomach bed-wetting of certain children's hospital's diagnosis and treatment.Wherein, man 113 example, female 87 example, 5 years old-8 years old age 110 example, 8 years old-10 years old 60 example, 11-15 year
30example.Be divided into four groups at random, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group.Four groups of infants comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.
Diagnostic criteria:
The enuresis refers to more than 5 years old child, can not Autonomous Control urinate, bed wetter after often falling asleep.
Diagnosis basis
1, sleep is comparatively dark, not easily wakes up, wets the bed every night or every several days, and very then a nocturia bed for several times.
2, age of onset is more than 5 one full year of life.
3, urine routine and urine cultivate discovery how without exception.
4, x-ray takes the photograph sheet inspection, and part infant can find that there is spina bifida occulta, urinary system x-ray radiography its textural anomaly visible.
5, deficiency of both the splenic and pulmonary QI: the middle enuresis of sleeping, frequent micturition and measure many, lusterless complexion, spiritlessness and weakness, inappetence, large loose stool is thin.Tongue is partially light, and moderate pulse is thin.
Therapeutic Method:
Embodiment 1 group: this group uses the granule of embodiments of the invention 1 to treat.Granule to be dissolved in the water or in milk, the amount of gavaging be 1.5g crude drug amount/time, gavage 2 times on the one, January is a course for the treatment of, treats 2 courses for the treatment of.
Embodiment 2 groups: this group uses the oral solutions of embodiments of the invention 1 to treat.Every day 2 times, each 2.5ml, oral.January is a course for the treatment of, treats 2 courses for the treatment of.
Embodiment 3 groups: this group uses the honey of embodiments of the invention 1 refining pill to treat.Every day 2 times, each 1 ball, namely single dose is 2.5g.January is a course for the treatment of, treats 2 courses for the treatment of.
Matched group: this group uses acetic acid to go amine vassopressin to treat.10 ~ 40ug/d, uses before sleeping.Within 5 days, be a course for the treatment of, treat 2 courses for the treatment of.
The standard of curative effect evaluation:
Cure: the not enuresis again after controlling.
Take a turn for the better: enuresis number of times reduces, and can wake and urinate in sleep.
Do not heal: the enuresis is unchanged.
Therapeutic outcome
Table 1 is the treatment situation contrast of each group
| Group | Cure | Take a turn for the better | Do not heal |
| Embodiment 1 group | 48（96%） | 2（4%） | 0（0%） |
| Embodiment 2 groups | 49（98%） | 1（2%） | 0（0%） |
| Embodiment 3 groups | 49（98%） | 1（2%） | 0（0%） |
| Matched group | 20（40%） | 8（16%） | 22（44%） |
As can be seen from Table 1, the treatment situation of three embodiment groups is better than the therapeutic effect of matched group, it can thus be appreciated that medicine of the present invention, at treatment deficiency of both the splenic and pulmonary QI type bed-wetting, therapeutic effect is good, determined curative effect.
Table 2 is the treatment time contrast of the healing of each group
| Group | Healing number | First course for the treatment of | Second course for the treatment of |
| Embodiment 1 group | 48 | 20（41.7%） | 28（58.3%） |
| Embodiment 2 groups | 49 | 28（57.1%） | 21（42.9%） |
| Embodiment 3 groups | 49 | 27（55.1%） | 22（44.9%） |
| Matched group | 20 | 5（25%） | 15（75%） |
As can be seen from Table 2, the healing number that first course for the treatment of of three embodiment groups cures is higher than matched group, it can thus be appreciated that medicine of the present invention, at treatment qi-deficiency of spleen and stomach bed-wetting, treatment speed is fast, instant effect.
Model case: children's hospital of Shandong Province accepts the boy baby of diagnosis and treatment, 8 years old, suffers from bed-wetting 1 year.Symptoms is: the middle enuresis of sleeping, frequent micturition and measure many, and lusterless complexion, spiritlessness and weakness, inappetence, large loose stool is thin.Tongue is partially light, and moderate pulse is thin, is qi-deficiency of spleen and stomach.The oral solutions of embodiments of the invention 1 is used to treat.Every day 2 times, each 2.5ml, oral.January is a course for the treatment of, treats 2 courses for the treatment of.In therapeutic process, do not occur other untoward reaction, 2 courses for the treatment of are carried out in treatment, cure.Later stage follows up half a year, does not recur.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. treat the medicine of deficiency of both the splenic and pulmonary QI type bed-wetting for one kind, it is characterized in that, comprise following raw medicinal material: Tremella, Radix Campanumoeae, swallow tail, Radix Panacis Quinquefolii, Semen Coicis, Herba Parnassiae Wightianae, Corm Eleocharitis, Macrura reevesii, Radix Caraganae Sinicae, Fructus Dracontomeli Duperreani, Fructus Aurantii, Radix Cinnamomi Camphorae, Herba Capsellae, Herba Agrimoniae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Menthae Rotundifoliae, Rhizoma Cibotii, Rhizoma Begoniae Willsonii, Auricularia, Radix Codonopsis Convolvulaceae, Carnis Arca inflata, Semen pini koraiensis, Caulis Sacchari sinensis, Hepar Sus domestica, Radix Caraganae Franchetianae, Siniperca chuatsi, the Radix Astragali, Herba avenae fatuae, Herba Themedae japonicae fruit and Radix Et Caulis Acanthopanacis Senticosi.
2. medicine as claimed in claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Tremella 15-25 weight portion, Radix Campanumoeae 10-15 weight portion, swallow tail 5-10 weight portion, Radix Panacis Quinquefolii 4-8 weight portion, Semen Coicis 10-14 weight portion, Herba Parnassiae Wightianae 7-13 weight portion, Corm Eleocharitis 8-14 weight portion, Macrura reevesii 5-9 weight portion, Radix Caraganae Sinicae 8-13 weight portion, Fructus Dracontomeli Duperreani 4-7 weight portion, Fructus Aurantii 10-15 weight portion, Radix Cinnamomi Camphorae 10-20 weight portion, Herba Capsellae 15-20 weight portion, Herba Agrimoniae 6-12 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5-10 weight portion, Herba Menthae Rotundifoliae 15-20 weight portion, Rhizoma Cibotii 4-8 weight portion, Rhizoma Begoniae Willsonii 4-7 weight portion, Auricularia 10-20 weight portion, Radix Codonopsis Convolvulaceae 5-10 weight portion, Carnis Arca inflata 3-6 weight portion, Semen pini koraiensis 10-15 weight portion, Caulis Sacchari sinensis 10-20 weight portion, Hepar Sus domestica 5-10 weight portion, Radix Caraganae Franchetianae 6-10 weight portion, Siniperca chuatsi 5-9 weight portion, Radix Astragali 15-20 weight portion, Herba avenae fatuae 10-20 weight portion, Herba Themedae japonicae fruit 6-15 weight portion and Radix Et Caulis Acanthopanacis Senticosi 15-20 weight portion.
3. medicine as claimed in claim 1 or 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Tremella 15-20 weight portion, Radix Campanumoeae 10-15 weight portion, swallow tail 5-10 weight portion, Radix Panacis Quinquefolii 4-8 weight portion, Semen Coicis 10-14 weight portion, Herba Parnassiae Wightianae 7-10 weight portion, Corm Eleocharitis 8-14 weight portion, Macrura reevesii 5-9 weight portion, Radix Caraganae Sinicae 8-10 weight portion, Fructus Dracontomeli Duperreani 4-7 weight portion, Fructus Aurantii 10-15 weight portion, Radix Cinnamomi Camphorae 15-20 weight portion, Herba Capsellae 15-20 weight portion, Herba Agrimoniae 6-12 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5-10 weight portion, Herba Menthae Rotundifoliae 15-20 weight portion, Rhizoma Cibotii 4-8 weight portion, Rhizoma Begoniae Willsonii 4-7 weight portion, Auricularia 15-20 weight portion, Radix Codonopsis Convolvulaceae 5-10 weight portion, Carnis Arca inflata 3-6 weight portion, Semen pini koraiensis 10-15 weight portion, Caulis Sacchari sinensis 15-20 weight portion, Hepar Sus domestica 5-10 weight portion, Radix Caraganae Franchetianae 6-10 weight portion, Siniperca chuatsi 5-9 weight portion, Radix Astragali 15-20 weight portion, Herba avenae fatuae 10-15 weight portion, Herba Themedae japonicae fruit 6-10 measures part and Radix Et Caulis Acanthopanacis Senticosi 15-20 weight portion.
4. the medicine as described in any one of claims 1 to 3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Tremella 18 weight portion, Radix Campanumoeae 12 weight portion, swallow tail 7 weight portion, Radix Panacis Quinquefolii 5 weight portion, Semen Coicis 12 weight portion, Herba Parnassiae Wightianae 12 weight portion, Corm Eleocharitis 12 weight portion, Macrura reevesii 6 weight portion, Radix Caraganae Sinicae 10 weight portion, Fructus Dracontomeli Duperreani 5 weight portion, Fructus Aurantii 12 weight portion, Radix Cinnamomi Camphorae 15 weight portion, Herba Capsellae 17 weight portion, Herba Agrimoniae 8 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 7 weight portion, Herba Menthae Rotundifoliae 17 weight portion, Rhizoma Cibotii 6 weight portion, Rhizoma Begoniae Willsonii 6 weight portion, Auricularia 16 weight portion, Radix Codonopsis Convolvulaceae 7 weight portion, Carnis Arca inflata 6 weight portion, Semen pini koraiensis 13 weight portion, Caulis Sacchari sinensis 16 weight portion, Hepar Sus domestica 7 weight portion, Radix Caraganae Franchetianae 8 weight portion, Siniperca chuatsi 7 weight portion, the Radix Astragali 17 weight portion, Herba avenae fatuae 13 weight portion, Herba Themedae japonicae fruit 8 weight portions and Radix Et Caulis Acanthopanacis Senticosi 16 weight portion.
5. the medicine as described in any one of Claims 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Tremella 18 weight portion, Radix Campanumoeae 12 weight portion, swallow tail 6 weight portion, Radix Panacis Quinquefolii 6 weight portion, Semen Coicis 12 weight portion, Herba Parnassiae Wightianae 8 weight portion, Corm Eleocharitis 12 weight portion, Macrura reevesii 6 weight portion, Radix Caraganae Sinicae 9 weight portion, Fructus Dracontomeli Duperreani 5 weight portion, Fructus Aurantii 12 weight portion, Radix Cinnamomi Camphorae 16 weight portion, Herba Capsellae 17 weight portion, Herba Agrimoniae 8 weight portion, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 6 weight portion, Herba Menthae Rotundifoliae 16 weight portion, Rhizoma Cibotii 6 weight portion, Rhizoma Begoniae Willsonii 6 weight portion, Auricularia 16 weight portion, Radix Codonopsis Convolvulaceae 6 weight portion, Carnis Arca inflata 5 weight portion, Semen pini koraiensis 12 weight portion, Caulis Sacchari sinensis 18 weight portion, Hepar Sus domestica 6 weight portion, Radix Caraganae Franchetianae 7 weight portion, Siniperca chuatsi 6 weight portion, the Radix Astragali 18 weight portion, Herba avenae fatuae 12 weight portion, Herba Themedae japonicae fruit 7 amount parts and Radix Et Caulis Acanthopanacis Senticosi 18 weight portion.
6. the medicine as described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is granule, and its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.07 ~ 0.09Mpa, relative density is the mastic of 1.14 ~ 1.17, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
7. the medicine as described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is oral solutions, and its preparation method is:
The first step, Radix Panacis Quinquefolii, Semen Coicis, Herba Parnassiae Wightianae and Corm Eleocharitis are mixed in proportion, be that the methanol of 80% ~ 90% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, pulverized 300-400 order powdered a, the quality of the methanol added is 2 ~ 6 times of first step mixture quality;
Second step, is mixed in proportion surplus stock medical material, pulverizes 300-400 order powdered b;
3rd step, adds the distilled water of the powder b quality 3 ~ 6 times obtained relative to second step, decocts 2 ~ 4 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make concentration reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, drying, obtains and gets dry extract, and pulverizes 300-400 order powdered c;
4th step, mixes powder a and powder c, adds the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stirs, boils, cooling, and filter, subpackage, namely sterilizing obtains oral solutions.
8. a preparation method for the medicine described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is honey refining pill, and its preparation method is:
Step 1: get crude drug and add 85-95% soak with ethanol 0.5-1.5 hour of 3-5 times amount, heating extraction 1-2 time, each 0.5-1.0 hour, filter to obtain extracting solution and medicinal residues, merge extractive liquid, be the ultrafiltration post ultrafiltration of 38000-84000 again through the molecular weight that dams, ultrafiltration decompression removing ethanol, during simmer down to 85-92 DEG C, relative density is the extractum of 1.03, becomes component 1; Step 2: the medicinal residues that step 1 obtains add 2-3 times amount water soaking 1.0-2.0 hour, extracts 1 time, is the extractum of 1.1, as component 2 by relative density during extracting solution heating under reduced pressure simmer down to 80-90 DEG C for 1.0-1.5 hour; Step 4: component 1, component 2 are mixed, adds and is twisted into honey refining pill relative to the Mel of mixture 2 times amount.
9. the medicine as described in any one of claim 1 to 5, it is characterized in that, the dosage form of described medicine is: tablet, film coated tablet, sugar coated tablet, soft capsule drop, suck agent, granule, enteric coated tablet, electuary, honey pill agent, oral liquid, solution, sublimed preparation, suppository, syrup, injection, powder, liniment, spray, drop, patch and liniment.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105412780A (en) * | 2015-11-26 | 2016-03-23 | 苏吉永 | Traditional Chinese medicine for treating spleen-lung qi deficiency type child enuresis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078578A (en) * | 2009-12-01 | 2011-06-01 | 付志成 | Traditional Chinese medicine composition for treating enuresis due to spleen-lung vital energy deficiency |
| CN104435614A (en) * | 2014-12-24 | 2015-03-25 | 周连才 | Pharmaceutical composition for treating infantile enuresis |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078578A (en) * | 2009-12-01 | 2011-06-01 | 付志成 | Traditional Chinese medicine composition for treating enuresis due to spleen-lung vital energy deficiency |
| CN104435614A (en) * | 2014-12-24 | 2015-03-25 | 周连才 | Pharmaceutical composition for treating infantile enuresis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412780A (en) * | 2015-11-26 | 2016-03-23 | 苏吉永 | Traditional Chinese medicine for treating spleen-lung qi deficiency type child enuresis |
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