CN107875256B

CN107875256B - Zhuang-medicine acupoint application plaster for treating insomnia and manufacturing method thereof

Info

Publication number: CN107875256B
Application number: CN201711175283.3A
Authority: CN
Inventors: 覃骊兰; 蓝毓营; 梁钢; 孙健; 覃甘梅; 谢沛桃; 卢健
Original assignee: Guangxi University of Chinese Medicine
Current assignee: Guangxi gengyang Health Technology Co.,Ltd.
Priority date: 2017-11-22
Filing date: 2017-11-22
Publication date: 2021-05-14
Anticipated expiration: 2037-11-22
Also published as: CN107875256A

Abstract

The invention belongs to the technical field of traditional Chinese medicine patches, and particularly relates to a Zhuang medicine acupoint application patch for treating insomnia and a manufacturing method thereof. The Zhuang medicine acupoint application plaster comprises the following raw materials in parts by weight: 120 portions of spina date seed and 170 portions of platycladi seed, 80 portions to 120 portions of grassleaf sweelflag rhizome, 80 portions to 120 portions of thinleaf milkwort root-bark, 45 portions to 70 portions of cinnabar and 45 portions to 70 portions of dried longan pulp. The invention starts from the modern clinical point, selects self-made ointment (consisting of Zhuang medicine) and corresponding acupuncture points under the guidance of the Zhuang medicine basic theory, and adopts Zhuang medicine acupuncture point application therapy with ethnic characteristics to treat insomnia.

Description

Zhuang-medicine acupoint application plaster for treating insomnia and manufacturing method thereof

Technical Field

The invention relates to a medicinal patch for acupoint application treatment, in particular to a Zhuang medicine acupoint application medicinal patch for treating insomnia and a manufacturing method thereof, and belongs to the technical field of traditional Chinese medicine patches.

Background

The acupoint pasting therapy of Zhuang medicine belongs to the traditional dominant therapy, and the modern is also called as acupoint pharmacotherapy, which is based on the theory of meridian theory, the medicine is ground into fine powder, mixed into paste by water, vinegar, wine, egg white, vegetable oil and the like, or the traditional Chinese medicine is decocted into paste and directly pasted on the acupoint, the internal organs are influenced by the meridian, the internal physiological functions of the organism are excited and adjusted, the whole body adjustment effects of treatment, immunity enhancement and the like are achieved, and the aims of exciting essence and qi, dredging qi and blood, adjusting yin and yang and balancing the blood are fulfilled. Zhuang Yi acupoint application therapy is an important component of traditional medical therapeutics, has a very long development history, and is popularized and applied to nearly hundreds of diseases of internal, external, female, children, five sense organs and skin in various departments at present, especially chronic and intractable diseases. Because of the toxic and side effects of chemical drugs, natural therapy has been advocated internationally, and application therapy is favored by people with the advantages of simplicity, convenience and low cost, and is popular with people, such as the emplastrum capsicum developed by Japan Kabushiki Kaisha.

The acupoint application therapy is the organic combination of acupuncture therapy and drug therapy, and is a comprehensive treatment method integrating meridians, acupoints and drugs. The applied medicine directly acts on the body surface acupuncture points, on one hand, the local blood vessels are expanded, the blood circulation is accelerated, and the effects of promoting blood circulation, removing blood stasis, clearing heat, removing toxicity, relieving pain, diminishing inflammation and improving the nutrition of peripheral tissues are achieved; on the other hand, the medicine can penetrate through skin and hair striae from exterior to interior, and pass through meridians to act on viscera to communicate exterior and interior, thereby exerting strong whole body regulation effect. Factors influencing transdermal penetration of drugs are closely related to intrinsic permeability of skin, in addition to physicochemical properties and pharmacological properties of drugs. Modern medicine has proven that drugs are completely absorbed from the skin. With the increase of toxic and side effects and drug resistance of oral medication, acupoint application therapy is increasingly receiving attention from the same people in the medical field. Transdermal drug delivery has the unique advantages of reducing drug toxicity and side effects, maintaining stable and lasting blood drug concentration and reducing drug administration times without the first pass effect of the liver and the damage of the gastrointestinal tract. The acupoint application therapy proposed according to the meridian theory has the effects of meridians and acupoints and the transdermal absorption dual treatment characteristics of medicines, the medicines stimulate the acupoints to locally generate the relative advantages of medicine concentration, can stimulate the meridian qi, and can strengthen the medicine concentration of a specific part through the absorption and the transmission of tiny blood vessels, thereby expanding the method and the thought for clinically treating various diseases. Moreover, due to the administration at the acupuncture points, the medicinal ingredients influence the physiological functions of multiple layers through the sensory transmission of meridians, and mutual excitation and coordination can be generated among the medicinal ingredients, so that the physiological amplification effect is caused, and the external treatment effect of the medicament is better than the internal treatment effect.

The insomnia is difficult to fall asleep, easy to wake up and early wake up in the middle of sleep, low sleep quality, obviously reduced sleep time, and the serious patients still do not sleep all night. Long-term insomnia is easy to cause distraction, fatigue and weakness, even headache, dreaminess, hyperhidrosis and hypomnesis, and can also cause a series of clinical symptoms and induce some psychosomatic diseases, and the insomnia is one of typical symptoms of senile depression. For insomnia, the traditional Chinese medicine has certain curative effect after oral administration, but is not easy to accept or persist by patients, and the medical cost is higher. Western medicines have quick response, but have certain toxic and side effects, are easy to relapse after being stopped taking the medicine, have the defects of drug resistance, addiction and the like, and are limited in clinical use. The study on insomnia is a difficult point and a hot point in the medical field at present, the pathogenesis of insomnia in modern medicine is not completely clarified, and a treatment method with direct strong pertinence to insomnia is not available. The Zhuang-Yi acupoint application therapy is a non-drug therapy which is distributed in the vast Zhuang-nationality areas, is a common therapy without harm, is very suitable for old and young weak bodies, particularly for people who are not liable to take medicines, and can not take medicines, while insomnia patients are mostly seen in the old, are often unwilling to take medicines and dislike to treat, and is particularly suitable for acupoint application therapy for the patients. In the wide Zhuang nationality, the Zhuang medicine acupoint application therapy has good curative effect on treating various diseases, has the characteristics of simplicity, convenience, cheapness and effectiveness, and is worthy of being popularized and applied to developing countries with the same economic level, especially to the eastern union countries.

Disclosure of Invention

The invention aims to provide a Zhuang medicine acupoint application plaster for treating insomnia by an acupoint application mode and a manufacturing method and a using method thereof, and aims to provide the Zhuang medicine acupoint application plaster for treating insomnia by adopting a Zhuang medicine acupoint application method with national characteristics and self-made ointment (consisting of Zhuang medicine) and corresponding acupoints under the guidance of the Zhuang medicine basic theory from the modern clinical point. The Zhuang medicine acupoint application plaster prepared by the invention directly absorbs the medicine from the acupoints and enters the organism in the using process, the meridian acupoint effect, the traditional Chinese medicine pharmacological effect and the transdermal permeation promoting effect are mutually superposed, the effect is directly obvious, and the medicine composition mainly aims at calming the heart and soothing the nerves, so that the Zhuang medicine acupoint application plaster is effective to insomnia with different symptoms and has wide adaptability.

In order to achieve the purpose, the invention adopts the following technical scheme:

a Zhuang medicine acupoint application plaster for treating insomnia comprises the following raw materials in parts by weight:

120 portions of spina date seed and 170 portions of platycladi seed, 80 portions to 120 portions of grassleaf sweelflag rhizome, 80 portions to 120 portions of thinleaf milkwort root-bark, 45 portions to 70 portions of cinnabar and 45 portions to 70 portions of dried longan pulp.

Preferably, the Zhuang medicine acupoint application plaster for treating insomnia comprises the following raw materials in parts by weight:

160 parts of spina date seed 140, 160 parts of platycladi seed 140, 90-100 parts of rhizoma acori graminei, 90-110 parts of polygala tenuifolia, 45-55 parts of cinnabar and 50-60 parts of arillus longan.

The invention also provides a manufacturing method of the Zhuang medicine acupoint application plaster for treating insomnia, which comprises the following specific steps: grinding the raw materials in parts by weight, adding pharmaceutically acceptable adjuvants such as water and Mel, concocting into paste, kneading into unguent with diameter of unitary coin, making into medicinal core, and fixing the medicinal core with medical adhesive plaster to obtain the final product.

The invention relates to a Zhuang medicine acupoint application medicine patch for treating insomnia, which comprises the following application methods: the medicine patch is applied to the acupuncture points of a patient for routine disinfection, and then the medicine patch is pasted on seven acupuncture points of Fengfu, Dazhui, Shenque, Xinshu, Taixi, Neiguan and Yongquan; wherein, the Xinshu point, the Taixi point, the Neiguan point and the Yongquan point are pasted on two sides 1 time a day for 6 to 12 hours each time, and the pasting time is 2 to 4 weeks.

The specific application method and the cautions of the Zhuang medicine acupoint application plaster for treating insomnia are as follows:

the patient is administered with conventional disinfection at acupuncture points, and the plaster is applied to FENGFU, DAZHUI, XINSHU acupuncture point (SHUANG), TAIXI acupuncture point (SHUANG), SHENQUE acupuncture point, NEIGUAN acupuncture point (SHUANG), and YONGQUAN acupuncture point (SHUANG), 1 time per day for 6-12 hr for 2-4 weeks.

And (3) operation specification: the patient without any special disease should be in a comfortable position, which is usually in a sitting or lying position. The acupoint selection is carried out according to the acupoint selection method of 'Zhuang-Yi acupuncture & moxibustion in China', the acupoint application is fully exposed, sweat is wiped off by a cotton ball, then 75% alcohol is used for disinfection, and after the skin is dried, the medicinal plaster is pasted to the corresponding acupoint.

Observation and nursing after acupoint application: the product has little irritation to skin, rarely causes discomfort or damage to skin, and can be stopped in time and treated according to symptoms if individual people are allergic to the product. During the application process, the applied part is immediately stopped if blister appears, and the applied material is removed. If large bubbles appear, the bottom of the small bubbles can be broken by a disinfection needle tool to discharge liquid in the bubbles; if the water bubbles are broken, the bag is disinfected and then wrapped by a piece of sterile gauze to prevent local infection. A small number of patients can have reddish local skin after being pasted, the pigmentation and mild pruritus are normal reactions, the curative effect is not influenced, and the treatment is not needed; if the local skin has itching and even pain, the sticking material should be taken down immediately and the patient is prevented from scratching, the patient can recover from the itching, and the tea oil can be smeared on the local part without smearing other anti-inflammatory medicines. The applied medicine should be fixed to prevent displacement or falling off, and local skin cleaning should be performed after the application is finished. Generally, the fabric can be cleaned by clean water at a proper temperature, and the soft cotton fabric can be lightly wiped. It is not suitable for scrubbing with irritant substances and hard cloth.

Note that: during application, people should fast spicy, greasy, frozen and uncooked food. It is not suitable for exposure to sunlight, soaking in cold water, swimming or doing strenuous activities for a long time during application. Avoid excessive sweating and prevent the applied medicine from falling off. Follow the instructions of the doctors to treat and strive to develop good living habits and maintain a good and optimistic mood.

The following are the medicinal material sources of the invention:

semen Ziziphi Spinosae, which is Rhamnaceae plant cortex ChoerospondiatisZiziphus jujuba Mill. var. spinosa （Bunge）Hu ex H.F. ChowDrying the mature seeds. Sweet, sour and mild in nature and taste. Master and slaveTreating: restlessness due to deficiency can lead to insomnia; palpitations, palpitation, spontaneous sweating due to asthenia, night sweat, body fluid consumption and thirst. Pharmacological effects are sedative and hypnotic effects, the spina date seed decoction is orally taken or injected into the abdominal cavity of a rat to calm and sleep, and the spina date seed can show the effects no matter in daytime or at night, in normal state or in coffee due to excitation state; ② analgesic, anticonvulsant and cooling function, hot plate method proves that 5 g/kg of spina date seed decoction has analgesic function when injected into abdominal cavity of mice, and has cooling function when injected or orally taken for mice, but can not antagonize experimental shock. (iii) an effect on the cardiovascular system,

spina date seed can cause continuous blood pressure reduction and heart conduction block. Discussion of each family: 1. compendium (compendium): spina date seed is sweet and moist, so the spine date seed is used for treating the symptoms of insomnia due to gallbladder deficiency, polydipsia and sweating due to deficiency; unprocessed for treating gallbladder heat and good sleep. All herbs that are full of jueyin and shaoyang are also specialized in the family of heart-mind and regulating the principle. 2. The book of medical science: the jujube kernel, semen Ziziphi Spinosae, mainly tonifies and the skin benefits heart blood, its qi turns into slightly warm when stir-fried to be fragrant, so it can penetrate heart qi to warm and help heart spirit. It is essential to treat mental bitterness and impairment of blood, mental deficiency, mental disability, palpitation, absentmindedness, amnesia, sweating, polydipsia due to mental fatigue. The fragrance is taken to warm the liver and the gallbladder, and if the gallbladder is deficient and blood is poor, the patient feels restless and sleepless, so that the liver and the gallbladder are full of blood, the five internal organs are calm and the patient sleeps to be calm; for excess heat in the gallbladder, it is mostly used for sleeping, and unprocessed to smooth qi. Because it is sweet and fried to be fragrant, and fragrant to enter spleen, it can enliven spleen yin, so it is indicated for chronic diarrhea and spleen injury due to anxiety.

Semen Platycladi (Platycladi, arborvitae, Cupressaceae)Platycladus orientalis （L.） FrancoThe dried mature kernels of (1). [ MAIN COMPONENT ] contains a large amount of fatty oil, a small amount of volatile oil, and saponin. [ PROPERTIES AND FLAVOUR ] sweet and neutral. It enters heart, kidney and large intestine meridians. [ main effects ]: 1. heart tonifying and blood nourishing: can be used for treating palpitation, vexation, insomnia, excessive anxiety, and heart and spleen injury due to blood deficiency and heart nourishing; 2. loosening bowel to relieve constipation: can be used for treating constipation due to intestinal dryness caused by yin deficiency and blood deficiency; 3. night sweat and spontaneous perspiration: can be used for treating yin deficiency and hyperhidrosis, such as<Bairen pill>. Preferably: it is suitable for patients with malnutrition of heart-mind, palpitation, insomnia, spermatorrhea, and night sweat; it is suitable for the elderly with chronic constipation. Baizi ren is mild in nature, not cold, not dry, sweet in taste and tonicPungent and moist with fragrant smell, it can penetrate heart and kidney, benefit spleen and stomach, and is suitable for nourishing. At present, the traditional Chinese medicine field generally considers that the semen boitae has the functions of nourishing the liver, calming the heart, soothing the nerves and arresting sweating, and can treat symptoms such as dysphoria, insomnia, palpitation due to fright, spontaneous sweating and night sweat. The modern pharmacology proves that the platycladi seed has the effects of tranquilizing and hypnotizing. The Chinese medicine argues that the semen boitae is sweet and sour in taste and mild in nature. Can nourish heart and liver, and has certain curative effect on mild insomnia. In clinic, the semen boitae is adopted to treat insomnia, and the remarkable and ideal curative effect can be achieved on mild or severe insomnia.

Rhizoma acori graminei is the rhizome of acorus gramineus soland of the Araceae family, the mineral name of the latin plant and animal is:Acorus tatarinowii Schott。the functional indications are as follows: resolve dampness, stimulate appetite, induce resuscitation, eliminate phlegm, refresh mind and promote intelligence. Can be used for treating epigastric fullness, inappetence, dysentery, coma, epilepsy, amnesia, and deafness. Regulating qi, promoting blood circulation, dispelling pathogenic wind, and removing dampness. It can be used for treating epilepsy, phlegm syncope, fever, coma, amnesia, qi block, deafness, vexation, gastralgia, abdominal pain, arthralgia due to wind-cold-dampness, superficial infection, toxic swelling, and traumatic injury. Pharmacological effects 1. effects on the central nervous system: the rhizoma acori graminei has a sedative effect, and the decoction or the volatile oil can reduce the spontaneous activity of the mice and relieve the attacking behavior of the mice fed in a single cage; can also prolong sleep time caused by pentobarbital sodium, and has synergistic effect on pentobarbital sodium with subthreshold hypnotic dose. The rhizoma acori graminei decoction has a certain antagonistic effect on mice convulsion caused by pentamtetranitrogen, the rhizoma acori graminei volatile oil has a strong cooling effect on the mice, and the tablet prepared from the rhizoma acori graminei rhizome water extract has a good curative effect when being clinically used for treating epilepsy and other nervous system diseases; 2. effect on the cardiovascular system: the rhizoma acori graminei volatile oil (beta-asarone) has the effect of dilating the coronary vessels of the guinea pig at a certain concentration; 3. action on digestive system: the rhizoma acori graminei decoction can promote secretion of digestive juice and stop abnormal fermentation of stomach and intestine by oral administration, and has the function of relieving smooth muscle spasm of intestinal canal, and the asarone in the rhizoma acori graminei can resist excitation of isolated intestinal canal caused by barium chloride; 4. particularly antifungal effect.

Polygala tenuifolia Willd is dried root of Polygala tenuifolia Willd or Polygala sibirica L. Bitter, pungent and warm in property and flavor, and mainly functions as follows: induce tranquilization and promote intelligence, dispel phlegm and resolve swelling. Can be used for treating insomnia, dreaminess, amnesia, pavor, absentmindedness, expectoration, skin and external diseases, swelling and pain of breast caused by imbalance between heart-yang and kidney-yin. Pharmacological action 1. phlegm eliminating action; 2. sedation and anticonvulsant: cortex et radix Polygalae root bark, whole root of cortex et radix Polygalae without wood core, and wood core of root have synergistic effect on barbiturates; 3. edema and diuresis; 4. bacteriostasis: the 10% polygala tenuifolia decoction measured by a paper method has an inhibiting effect on pneumococci; 5. hemolysis: polygala tenuifolia and Platycodon grandiflorum, similar to each other, contain saponins and also have the effect of dissolving erythrocytes. Discussion of each family 1, Shen nong Ben Cao Jing: mainly cough up and hurting middle energizer, tonify deficiency, eliminate pathogenic qi, benefit nine orifices, benefit wisdom, improve hearing and eyesight, not forget, strengthen strength. 2. The book Ben Cao Jing Ji Zhu: killing Tianxiong and Fu Zi poison. 3. The miscellaneous records of famous physicians: heart-qi securing, palpitation stopping, essence replenishing, heart-qi and diaphragm qi removing, heat in skin, and yellow complexion. 4. Treatise on herb Property: it is indicated for amnesia, strengthening yang and regulating the flow of qi and dream.

Cinnabar, a sulfide mineral cinnabar, mainly contains mercuric sulfide (HgS). Latin plant animal mineral name: cinnabar, Cinnabar, mainly contains Mercuric sulfide (Mercuric sulfide HgS) with a mercury content of 85.41%, but is often mixed with realgar, apatite, asphalt and other impurities. Nature, flavor and meridian tropism: sweet and slightly cold. Has little toxicity. It enters heart meridian. The functional indications are as follows: tranquilizing the heart; clearing away heat and toxic materials; improving eyesight. Mainly cause mania; palpitations; restlessness; insomnia; vertigo; dizziness; pyogenic infections; sores and ulcers. Pharmacological action 1. the product has sedative and hypnotic effects. 2. It can be used for external application for killing bacteria and parasites on skin. 3. Effect on digestive system: the artificial cinnabar can be used for feeding rabbit with stomach of 0.1-0.2g/kg, and can increase total nitrogen discharged from urine and body weight. Discussion of each house 1. this book of changes: nourishing spirit, calming soul, tonifying qi and improving eyesight. 2. The bibliography: promoting blood circulation, relieving restlessness, quenching thirst, replenishing vital essence, refreshing mind, caring skin, relieving abdominal pain, and removing toxic substance, qi and scabies. 3. Compendium of Dansha, Polygala tenuifolia and Long Gu, etc. for nourishing heart-qi; nourishing heart blood like Dang Gui and Dan Shen; nourishing kidney like wolfberry fruit and rehmannia root; nourishing spleen together with Magnolia officinalis and fructus Zanthoxyli; together with nan xing and Chuan Wu, they can dispel wind. Has the functions of improving eyesight, preventing miscarriage, detoxifying, sweating, and having actions with assistance, which cannot be seen all the time.

Arillus longan is aril arillus longan Dimocarpus longan Lour. Harvesting mature fruits in summer and autumn, drying, removing shells and cores, and drying in the sun until the fruits are dry and sticky. The functional indications are as follows: tonify heart and spleen, tonify qi and blood, and induce tranquilization. For asthenia, insomnia, amnesia, palpitation, and severe palpitation. Discussion of each family: 1. the book of medical science: longan, longan and semen euryales can tonify yin and blood, and when blood is lost from the upper part, the spleen-invigorating decoction, lotus seed and semen euryales can tonify spleen yin, so that spleen can tonify blood and enter meridians. For example, if the mind is tired, the heart meridian has less blood, so that the Sheng Di and Mai Dong can nourish the heart blood. Also, the prepared rhizome of rehmannia and Chinese angelica root, radix rehmanniae and Chinese angelica root, radix Angelicae sinensis have the effect of nourishing liver blood due to muscle and bone strain overstrain and liver deficiency. 2. The book Jing: the five internal organs are mainly responsible for pathogenic qi, calm mind and anorexia, and can strengthen soul and improve intelligence after long-term administration. 4. The Yunnan herbal medicine: nourish blood and induce tranquilization, promote mentality and arrest sweating, stimulate appetite and benefit spleen.

The pharmacological functions of the components of the invention are as follows:

semen Ziziphi Spinosae can be used for treating vexation and insomnia; palpitations and palpitations; spontaneous perspiration and night sweat due to asthenia, and has tranquilizing and hypnotic effects; semen Platycladi has effects of nourishing liver, calming heart, tranquilizing mind, and arresting sweating, and can be used for treating vexation, insomnia, palpitation due to fright, spontaneous perspiration, and night sweat; rhizoma Acori Graminei has effects of eliminating dampness, promoting appetite, inducing resuscitation, eliminating phlegm, refreshing mind and improving intelligence; cortex et radix Polygalae has tranquilizing and intelligence improving, expectorant, repercussive, tranquilizing, and anticonvulsive effects; cinnabaris has effects of tranquilizing mind, clearing away heat and toxic materials, improving eyesight, tranquilizing mind, and improving sleep, and can kill skin bacteria and parasites when used externally; longan pulp can nourish heart and spleen, tonify qi and blood, and induce tranquilization. The invention comprehensively utilizes the effects of calming the heart, soothing the nerves, tranquilizing, hypnotizing and the like of all the medicines, prepares a medicinal patch (consisting of Zhuang medicine) under the guidance of the Zhuang medicine basic theory, and treats the insomnia by adopting the Zhuang medicine acupoint application therapy with national characteristics. Through the action of the medicines and the corresponding acupuncture points, the Zhuang medicine acupuncture point application plaster prepared by the invention directly absorbs the medicines from the acupuncture points and enters the organism in the using process, the meridian acupoint effect, the traditional Chinese medicine pharmacological effect and the transdermal permeation promoting effect are mutually superposed, the effect is directly obvious, and the aim of effectively treating insomnia is achieved.

The invention has the beneficial effects that:

1. from the modern clinical point of view, the invention selects self-made ointment (consisting of Zhuang medicine) and corresponding acupuncture points under the guidance of Zhuang medicine basic theory, and adopts Zhuang medicine acupuncture point pasting therapy with national characteristics to treat insomnia. The Zhuang-medicine acupoint application plaster for treating insomnia disclosed by the invention is directly pasted on the acupoints of a human body through medicines, directly stimulates the acupoints through the medicines, is absorbed into an organism from the acupoints, and can effectively treat insomnia by mutually superposing the meridian acupoint effect, the traditional Chinese medicine pharmacological effect and the transdermal permeation promoting effect, so that the effect is directly and obviously. Moreover, the adoption of the medicinal plaster avoids the defect that the spleen and the stomach are damaged by oral medicines to a certain extent, and is particularly suitable for the weak bodies of the old and the young. Moreover, the composition of the medicine mainly aims at calming heart and soothing nerves, so the medicine is effective to insomnia with different syndromes, and has wide application. For the sub-health state of insomnia, the method plays an advantage of internal and external co-treatment in the prevention and treatment of diseases, and most groups are willing to accept the method.

2. The Zhuang medicine acupoint application plaster for treating insomnia is prepared from common Zhuang medicines, has rich medicine sources, low price and small dosage, can reduce the economic burden of patients, can save a large amount of medicinal materials, and is cheap and frugal; the compatibility and the preparation of the acupoint application are simple and convenient, special medical equipment and instruments are not needed, and the acupoint application can be used at any time by study and is convenient for clinical popularization and family use. In addition, the use of the medicine is relatively safe, even if some skin irritation reaction occurs in clinical application, symptomatic treatment can be given in time, the symptoms disappear quickly, and the medicine can be used continuously.

3. Compared with the defects of the conventional method for treating insomnia by adopting oral traditional Chinese medicines or western medicines, the Zhuang medicine acupoint application patch prepared by the invention has the advantages of obvious effect on treating insomnia, low cost, high safety and more acceptable treatment mode; the technical scheme of the invention is adopted to treat insomnia, is a convenient, rapid and effective treatment method for treating insomnia, widens the treatment thought of insomnia, and arranges the experience of treating insomnia by using Zhuang medicine acupoint application therapy.

Drawings

FIG. 1 is a schematic structural diagram of a medical adhesive plaster used for manufacturing a Zhuang-nationality acupoint application patch for treating insomnia, wherein the medical adhesive plaster comprises an anti-sticking layer 1, an anti-seepage ring 2, a controlled release cotton 3, an anti-seepage layer 4, a white non-woven adhesive cloth 5.

Detailed Description

Example 1

120 parts of spina date seed, 120 parts of platycladi seed, 80 parts of rhizoma acori graminei, 80 parts of polygala tenuifolia, 45 parts of cinnabar and 45 parts of arillus longan.

The manufacturing method of the Zhuang medicine acupoint application plaster for treating insomnia comprises the following steps: grinding the above raw materials, mixing with appropriate amount of water and a little Mel to obtain paste, kneading into unguent with diameter of unitary coin, making into medicine core, and fixing the medicine core with medical adhesive plaster (wound dressing manufactured by 3L medical products group GmbH in Jiangxi).

The strong medicine acupoint application medicine patch for treating insomnia comprises the following application methods: applying the patch to seven acupoints, such as Fengfu, Dazhui, Shenque, Xinshu, Taixi, Neiguan and Yongquan, for conventional disinfection; wherein, the Xinshu point, the Taixi point, the Neiguan point and the Yongquan point are pasted on two sides 1 time a day for 6 hours each time, and the pasting time is 4 weeks.

Example 2

140 parts of spina date seed, 135 parts of platycladi seed, 100 parts of rhizoma acori graminei, 100 parts of polygala tenuifolia, 55 parts of cinnabar and 60 parts of arillus longan.

The manufacturing method of the Zhuang medicine acupoint application plaster for treating insomnia comprises the following steps: grinding the raw materials in parts by weight, mixing a proper amount of water and a little honey into paste, rubbing into ointment with the diameter of a unitary coin, preparing the ointment into a medicine core for later use, and fixing the medicine core by using a medical adhesive plaster to prepare the medicine plaster.

The strong medicine acupoint application medicine patch for treating insomnia comprises the following application methods: the patient is sterilized at the acupuncture points by routine, and the plaster is applied to Fengfu, Dazhui, Xinshu acupuncture points (double), Taixi acupuncture points (double), Shenque acupuncture point, Neiguan acupuncture point (double) and Yongquan acupuncture point (double) 1 time a day for 8 hours each time, and the application time is 3 weeks.

Example 3

150 parts of spina date seed, 150 parts of platycladi seed, 100 parts of rhizoma acori graminei, 100 parts of polygala tenuifolia, 50 parts of cinnabar and 50 parts of arillus longan.

The manufacturing method of the Zhuang medicine acupoint application plaster for treating insomnia comprises the following steps: grinding the above raw materials, adding appropriate amount of water and a little Mel, concocting into paste, kneading into unitary coin-sized ointment, making into medicine core, and fixing the medicine core with medical adhesive plaster (wound dressing manufactured by Jiangxi 3L medical products group GmbH) to obtain the final product.

The strong medicine acupoint application medicine patch for treating insomnia comprises the following application methods: applying the patch to seven acupoints, such as Fengfu, Dazhui, Shenque, Xinshu, Taixi, Neiguan and Yongquan, for conventional disinfection; wherein, the Xinshu point, the Taixi point, the Neiguan point and the Yongquan point are pasted on two sides 1 time a day for 12 hours each time, and the pasting time is 4 weeks.

Example 4

170 parts of spina date seed, 170 parts of platycladi seed, 120 parts of rhizoma acori graminei, 120 parts of polygala tenuifolia, 70 parts of cinnabar and 70 parts of arillus longan.

The manufacturing method of the Zhuang medicine acupoint application plaster for treating insomnia comprises the following steps: grinding the raw materials in parts by weight, adding pharmaceutically acceptable adjuvants such as water and Mel, concocting into paste, kneading into unitary coin-sized ointment, making into medicine core, and fixing the medicine core with medical adhesive plaster (wound dressing produced by Jiangxi 3L medical products group Co., Ltd.) to obtain the final product.

The strong medicine acupoint application medicine patch for treating insomnia comprises the following application methods: applying the patch to seven acupoints, such as Fengfu, Dazhui, Shenque, Xinshu, Taixi, Neiguan and Yongquan, for conventional disinfection; wherein, the Xinshu point, the Taixi point, the Neiguan point and the Yongquan point are pasted on two sides 1 time a day for 12 hours each time, and the pasting time is 2 weeks.

Example 5

155 parts of spina date seed, 150 parts of platycladi seed, 95 parts of rhizoma acori graminei, 100 parts of polygala tenuifolia, 50 parts of cinnabar and 55 parts of arillus longan.

The strong medicine acupoint application medicine patch for treating insomnia comprises the following application methods: the patient is administered with conventional disinfection at acupuncture points, and the plaster is applied to FENGFU, DAZHUI, XINSHU acupuncture point (SHUANG), TAIXI acupuncture point (SHUANG), SHENQUE acupuncture point, NEIGUAN acupuncture point (SHUANG), and YONGQUAN acupuncture point (SHUANG), 1 time per day for 12 hr, and the application time is 4 weeks.

Application effects

To further illustrate the effect of the Zhuang medicine acupoint application plaster for treating insomnia, the inventor performed clinical tests by using the Zhuang medicine acupoint application plaster for treating insomnia prepared in example 3 of the present invention, specifically, the following conditions were:

(1) the adopted medicine patch is as follows: the Zhuang-medicine acupoint application plaster for treating insomnia prepared in the embodiment 3 of the invention.

(2) The application method comprises the following steps: the medicine patch is applied to the acupuncture points of a patient for conventional disinfection, and is fixed by being stuck on Fengfu, Dazhui, Xinshu acupuncture points (double), Taixi acupuncture points (double), Shenque acupuncture point, Neiguan acupuncture point (double) and Yongquan acupuncture point (double), 1 time every day and 12 hours every time for 1 month (28 days) of treatment.

(3) The invention carries out clinical effect observation, randomly selects 90 cases of middle-aged and elderly depression and insomnia hospitalized patients in a high mountain with pointed peaks Shanxi city Hospital in Guangxi Bingdu, and divides the patients into three clinical effect observation groups according to a random method. The first group is acupoint application treatment group (treatment group), 30 cases; the second group is a treatment group combining acupoint application and conventional western medicines (combined treatment group), 30 cases; the third group is a western medicine conventional treatment control group (control group), 30 cases. The western medicine group adopts: buspirone tablet, manufacturer: jiangsu Enhua pharmaceutical industry, Inc. Batch number: 20130201. the usage and dosage are as follows: it is administered orally at night before sleep, 2 tablets each time, 1 time daily. The treatment period is 1 month. The acupoint application treatment group adopts the Zhuang medicine acupoint application plaster for treating insomnia and the corresponding application method which are prepared in the embodiment 3 of the invention.

(4) And (3) analyzing test results and data:

comparison of clinical overall efficacy after three groups of treatments: the total effective rate of the acupoint application group is 86.7%, the total effective rate of the combined western medicine group is 96.6%, the total effective rate of the western medicine control group is 83.3%, and the comparison of the three groups has obvious difference (P is less than 0.01). The effect of treating the insomnia caused by depression of the middle-aged and the elderly by adopting the Zhuang medicine acupoint application plaster for treating the insomnia and the corresponding application method is definite.

The clinical symptoms before and after treatment are compared, and the obvious difference (P is less than 0.01) exists before and after the acupoint application treatment group.

The analysis of the single symptom of insomnia improved by the acupoint application therapy comprises the following steps: according to the clinical research results, the symptoms (physical signs) of the western medicine combination, such as difficult sleep, easy sleep, difficult sleep all night, emotional disorder and the like, are obviously improved, and the difference is obvious (P is less than 0.05) compared with other two groups. The acupoint application group and the western medicine control group respectively relieve the symptoms to different degrees, but have no significant difference (P > 0.05). The Zhuang medicine acupoint application plaster for treating insomnia and the corresponding acupoint application therapy have the effect of relieving symptoms related to depression and insomnia.

Analysis of relevant indexes NA and (5-HT) of depression and insomnia improvement by acupoint application therapy: the research shows that after the acupoint application group is treated by one course of treatment, the NA is not significantly different from the NA before and after (5-HT) (P is greater than 0.05), but the index concentration tends to increase.

As can be seen from the above, the Zhuang medicine acupoint application plaster for treating insomnia and the corresponding acupoint application method have obvious effect on treating insomnia.

Claims

1. A Zhuang medicine acupoint application plaster for treating insomnia is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight:

120 portions of spina date seed and 170 portions of platycladi seed, 80 portions to 120 portions of rhizoma acori graminei, 80 portions to 120 portions of polygala tenuifolia, 45 portions to 70 portions of cinnabar and 45 portions to 70 portions of arillus longan;

the Zhuang medicine acupoint application plaster for treating insomnia is prepared by the following steps: grinding the raw materials in parts by weight, adding appropriate amount of water and Mel, concocting into paste, kneading into unguent with diameter of unitary coin, making into medicinal core, and fixing the medicinal core with medical adhesive plaster to obtain medicinal patch;

the specific application method of the Zhuang medicine acupoint application plaster for treating insomnia comprises the following steps:

the patient is administered with conventional disinfection at acupuncture points, and the plaster is applied to Fengfu, Dazhui, Xinyu, Taixi, Shenque, Neiguan and Yongquan acupuncture points, wherein the Xinyu, Taixi, Neiguan and Yongquan acupuncture points are applied on both sides for 1 time per day, 6-12 hours per time and 2-4 weeks.

2. The Zhuang medicine acupoint application patch for treating insomnia as claimed in claim 1, wherein: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 160 parts of spina date seed 140, 160 parts of platycladi seed 140, 90-100 parts of rhizoma acori graminei, 90-110 parts of polygala tenuifolia, 45-55 parts of cinnabar and 50-60 parts of arillus longan.