CN104873745B - A kind of Chinese medicine that treating insomnia and preparation method - Google Patents

A kind of Chinese medicine that treating insomnia and preparation method Download PDF

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CN104873745B
CN104873745B CN201510308690.1A CN201510308690A CN104873745B CN 104873745 B CN104873745 B CN 104873745B CN 201510308690 A CN201510308690 A CN 201510308690A CN 104873745 B CN104873745 B CN 104873745B
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liver
honey
chinese medicine
treating insomnia
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CN104873745A (en
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滕乐生
吕冰聪
李玉婧
刘艳
逯家辉
孟庆繁
谢晶
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Jilin University
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Jilin University
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Abstract

The invention discloses a kind of Chinese medicine compositions for treating insomnia, mainly by semen ziziphi spinosae, the seed of Oriental arborvitae, Radix Polygalae, cortex albiziae, the vine of multiflower knotweed, lily, keel, amber, mother-of-pearl, rhizoma corydalis, ganoderma lucidum, lotus seeds, jujube, dried longan, the composition such as honey, is made of traditional processing procedure.With mental-tranquilization, benefiting yin arrest sweating, it is calming the liver, clear liver and improve vision, tonifying spleen and stopping diarrhea the effects of, all medicines cooperate with compatibility, can enter the heart channel of Hang-Shaoyin, Liver Channel, have mental-tranquilization, benefiting yin arrest sweating, it is calming the liver, clear liver and improve vision, tonifying spleen and stopping diarrhea the effects of, honey seasoning is added to upset and having a sleepless night has significant curative effect to liver depression forming fire caused by Menopause, and without side-effects, no dependence.

Description

A kind of Chinese medicine that treating insomnia and preparation method
Technical field:
The present invention discloses a kind of Chinese medicine for treating insomnia, while additionally providing the preparation method of the Chinese medicine, belongs to Chinese medicine system Medicine technical field.
Technical background:
Insomnia be often referred to patient sleeping time and (or) quality it is inadequate, influence next day study, live, work, health With a kind of subjective experience of mood, including can not fall asleep or cannot keep sleep state, often awakening and (or) morning wake up too early, sleep Dormancy depth or frequency are too short.It can cause the feeling of fatigue of people, uneasiness, general malaise, listless, delay of response, headache, memory Do not collect medium symptom, seriously will lead to schizophrenia, common clinical type has: Primary sleep disorders, secondary sleep disturbance, Pseudoinsomnia., there are environment reason, individual factors, body reason, mental element, emotional factor etc. in common the reason of leading to insomnia. According to Traditional Chinese medical theory, predominantly internal organs are in disorder the reason of insomnia, the enriching yin function of the temperature of the especially heart positive function and kidney It can coordinate, deficiency of qi and blood, imbalance of yin and yang etc..
Climacteric insomnia is that climacteric ovarian estrogen secretion gradually decreases and pituitary gonadotropic hormone increases, and causes nerve Endocrine a period of time sexual maladjustment, the imbalance of hypothalamic-pituitary-ovarian axis feedback system and function disorder of autonomic nervous system, generate The main reason for depression, anxiety disorder, these often generate insomnia.Patient can be treated using the dialectical compatibility of traditional Chinese medicine, Comprehensively regulating viscera function, Yin Yang balancing emotion regulation, while cooperating certain self-control can gradually rehabilitation.
Nowadays treatment, which is had a sleepless night, is mostly used Western medicine, such as hypnotic, tranquilizer etc., but since tranquilizer makes patient's passive sleep more, There are many adverse reactions, dizzy brain rises within such as second day, absent minded, DOMS, failure of memory, loss of appetite etc., Since drug is metabolized through liver kidney, long-term use can cause to bear to liver kidney, and some meetings cause liver enlargement, hepatalgia, albumen Urine, blood urine etc., and will cause the dependence of body and psychology, it is also easy to produce withdrawal reaction, is not suitable for long-term treatment.Modern life Pressure living is big, and rhythm of life is fast, and exercise machine can be lacked, and local environment is seriously polluted, and body and mind is all tired, mends in addition without good sleep Physical strength is filled, the disease of other life threatenings is easily caused, therefore treats insomnia and has become extremely urgent one of task.
Summary of the invention:
The present invention provides a kind of Chinese medicine for treating insomnia, has apparent clinical effectiveness to treatment insomnia, and without poison Side effect and dependence.
The present invention further discloses a kind of preparation methods of Chinese medicine for treating insomnia, are suitable for industrialized production.
A kind of Chinese medicine for treating insomnia of the present invention, it is characterised in that be made by ratio of weight and the number of copies of following drug :
Semen ziziphi spinosae 15 ~ 30, the seed of Oriental arborvitae 5 ~ 10, Radix Polygalae 3 ~ 6, cortex albiziae 8 ~ 14, the vine of multiflower knotweed 9 ~ 15, lily 15 ~ 20, keel 10 ~ 15, amber 1.5 ~ 5, mother-of-pearl 15 ~ 25, rhizoma corydalis 1.5 ~ 5, ganoderma lucidum 10 ~ 15, lotus seeds 5 ~ 10, jujube 5 ~ 10, dried longan 5 ~ 10, Honey 20 ~ 30.
A kind of Chinese medicine for treating insomnia of the present invention, optimum ratio are as follows:
Semen ziziphi spinosae 20, the seed of Oriental arborvitae 8, Radix Polygalae 4, cortex albiziae 12, the vine of multiflower knotweed 13, lily 17, keel 13, amber 3, mother-of-pearl 20, rhizoma corydalis 3, ganoderma lucidum 12, lotus seeds 7, jujube 7, dried longan 7, honey 25.
A kind of preparation method of Chinese medicine for treating insomnia of the present invention, comprising the following steps:
It weighing each herbal medicine according to the above ratio, removes impurity, 3 ~ 5 times of doses are decocted in water for oral dose, and fried 3 times, every time 60 ~ 120 Minute fried completion, merges and decocts, and honey is added to obtain the final product.
Various dosage forms can also be made up in Chinese medicine composition of the invention of this field customary preparation methods, as capsule, Tablet, granule, pill etc..
Usage and dosage: 10 ~ 15g every time takes orally 3 times a day.
Indication: insomnia, liver depression forming fire card.
Side's solution of drug of the present invention is as follows:
In prescription of the present invention: semen ziziphi spinosae is mild-natured, it is sweet in flavor, the heart channel of Hang-Shaoyin, Liver Channel can be entered, the function with mental-tranquilization, benefiting yin arrest sweating Effect;The seed of Oriental arborvitae, it is mild-natured, sweet in flavor, the heart channel of Hang-Shaoyin, kidney channel, large intestine channel can be entered, have effects that mental-tranquilization, relax bowel and defecation;Radix Polygalae is micro- Temperature, acrid flavour are bitter, can enter lung channel, the heart channel of Hang-Shaoyin, have effects that antitoxic heart-soothing and sedative, eliminating the phlegm are had one's ideas straightened out;Cortex albiziae is mild-natured, sweet in flavor, can enter the heart channel of Hang-Shaoyin, Liver Channel has effects that tranquilizing the mind relieve stagnation, activating blood circulation and reducing swelling;The vine of multiflower knotweed, it is mild-natured, sweet in flavor, the heart channel of Hang-Shaoyin, Liver Channel can be entered, have mental-tranquilization, The effect of dredging collateral wind-dispelling;Lily cold nature, sweet-bitter flavor can enter the heart channel of Hang-Shaoyin, lung channel, have effects that moistening lung to arrest cough, clearing away the heart fire and tranquillizing;Dragon It is bone cold nature, sweet in flavor, the heart channel of Hang-Shaoyin, Liver Channel can be entered, there is arresting convulsion to calm the nerves, calming the liver effect;Amber is mild-natured, sweet in flavor, can enter the heart Through, Liver Channel, bladder meridian, have effects that arresting convulsion calm the nerves, promoting blood circulation to remove blood stasis;Mother-of-pearl is the nacre of shell-fish shell, property It is cold, taste is salty, can enter Liver Channel, the heart channel of Hang-Shaoyin, have effects that it is calming the liver, clear liver and improve vision;Rhizoma corydalis is warm-natured, acrid flavour is bitter, can enter Liver Channel, Stomach meridian has effects that blood-activating and qi-promoting, analgesic are calmed the nerves;Ganoderma lucidum sweet-bitter flavor, mild-natured, return heart, lung, liver, the spleen channel;Can mental-tranquilization, Support lung QI invigorating, Qi management and blood stasis, nourishing liver and spleen;Lotus seeds soothe the nerves, and have the function of clearing heat-fire, and conduce to sleep;As benefit Beneficial medicine, tonifying spleen and stopping diarrhea, kidney-nourishing arresting seminal emission, mental-tranquilization;Flavones that jujube contains, glycoside A have calm, hypnosis and decompression work With nourishing blood and tranquilization being played, the effect of liver soothing and depression relief;Longan contains the elements such as a large amount of iron, potassium, can promote hemoglobin again Palpitaition, palpitation, insomnia, amnesia caused by giving birth to treat because of anaemia;All medicines cooperate with compatibility, can enter the heart channel of Hang-Shaoyin, Liver Channel, have nourishing heart peace Mind, benefiting yin arrest sweating, it is calming the liver, clear liver and improve vision, tonifying spleen and stopping diarrhea the effects of, addition honey seasoning, to caused by Menopause Liver depression forming fire, upsets and having a sleepless night has significant curative effect, and without side-effects, no dependence.
The positive effect of the present invention is: selected for the pathogenesis of insomnia based on China's traditional Chinese medical theory Pure Chinese herbal medicine prescription is made drug by science, has treating both manifestation and root cause of disease, controls benefit and synchronizes, and mental-tranquilization, benefiting yin arrest sweating is put down The effect that liver checking exuberance of yang, calming the liver kidney tonifying and clearing heat-fire conduce to sleep;Rapid-action with short treating period, toxic side effect is small, and expense is low The features such as.
Specific embodiment:
The present invention will be further described combined with specific embodiments below.
Embodiment 1
15 grams of semen ziziphi spinosae, 10 grams of the seed of Oriental arborvitae, 3 grams of Radix Polygalae, 14 grams of cortex albiziae, 9 grams of the vine of multiflower knotweed, 16 grams of lily, 10 grams of keel, 1.5 grams of amber, 20 grams of mother-of-pearl, 3 grams of rhizoma corydalis, 13 grams of ganoderma lucidum, 5 grams of lotus seeds, 5 ~ 10 grams of jujube, 5 ~ 10 grams of dried longan, honey 20 grams.It weighs each herbal medicine according to the above ratio, removes impurity, being decocted in water for oral dose for 5 times of doses fried 3 times, is decocted for 60 ~ 120 minutes every time System is completed, and is merged and is decocted, and honey is added to obtain the final product.
Embodiment 2
18 grams of semen ziziphi spinosae, 8 grams of the seed of Oriental arborvitae, 3 grams of Radix Polygalae, 10 grams of cortex albiziae, 10 grams of the vine of multiflower knotweed, 20 grams of lily, 15 grams of keel, 1.5 grams of amber, 18 grams of mother-of-pearl, 1.5 grams of rhizoma corydalis, 10 grams of ganoderma lucidum, 10 grams of lotus seeds, 8 grams of jujube, 10 grams of dried longan, honey 20 Gram.Weigh each herbal medicine according to the above ratio, remove impurity, 4 times of doses are decocted in water for oral dose, fried 3 times, every time 60 ~ 120 minutes it is fried It completes, merges and decoct, honey is added to obtain the final product.
Embodiment 3
20 grams of semen ziziphi spinosae, 8 grams of the seed of Oriental arborvitae, 4 grams of Radix Polygalae, 12 grams of cortex albiziae, 13 grams of the vine of multiflower knotweed, 17 grams of lily, 13 grams of keel, 3 grams of amber, 20 grams of mother-of-pearl, 3 grams of rhizoma corydalis, 12 grams of ganoderma lucidum, 7 grams of lotus seeds, 7 grams of jujube, 7 grams of dried longan, 25 grams of honey.By upper The ratio of stating weighs each herbal medicine, removes impurity, and 5 times of doses are decocted in water for oral dose, and fried 3 times, fried completion in 60 ~ 120 minutes every time is closed And decoct, honey is added to obtain the final product.
Embodiment 4
25 grams of semen ziziphi spinosae, 6 grams of the seed of Oriental arborvitae, 6 grams of Radix Polygalae, 12 grams of cortex albiziae, 13 grams of the vine of multiflower knotweed, 20 grams of lily, 13 grams of keel, 5 grams of amber, 15 grams of mother-of-pearl, 5 grams of rhizoma corydalis, 15 grams of ganoderma lucidum, 8 grams of lotus seeds, 5 grams of jujube, 8 grams of dried longan, 25 grams of honey.By upper The ratio of stating weighs each herbal medicine, removes impurity, and 3 times of doses are decocted in water for oral dose, and fried 3 times, fried completion in 60 ~ 120 minutes every time is closed And decoct, honey is added to obtain the final product.
Embodiment 5
30 grams of semen ziziphi spinosae, 5 grams of the seed of Oriental arborvitae, 3 grams of Radix Polygalae, 12 grams of cortex albiziae, 14 grams of the vine of multiflower knotweed, 15 grams of lily, 10 grams of keel, 3 grams of amber, 20 grams of mother-of-pearl, 5 grams of rhizoma corydalis, 10 grams of ganoderma lucidum, 10 grams of lotus seeds, 10 grams of jujube, 8 grams of dried longan, 30 grams of honey.It presses Aforementioned proportion weighs each herbal medicine, removes impurity, and 5 times of doses are decocted in water for oral dose, and fried 3 times, fried completion in 60 ~ 120 minutes every time, Merge and decoct, honey is added to obtain the final product.
The curative effect of drug of the present invention is further proved by specific clinical case:
Case 1:
Mr. Wang, female, 46 years old, high school mathematics teacher, the form master need to read and make comments hundred parts of examination papers or operation daily, the heavy burden of family, Pressure is larger, often difficulty falling asleep, cannot reach deep sleep, and daily sleeping time is short, is often accompanied by nightmare, causes to work by day Deficient in energy, evening mood is irritated, Sleep hyperhidrosis, seriously affects life, belongs to menopause symptom.1 system through the embodiment of the present invention Standby drug therapy, the state of an illness is improved after 20 days, gather colour, and sleep degree is deepened after 40 days, no nightmare, base after 60 days This recovery from illness is easily fallen asleep, and is slept after sleep long and deep, daytime is full of vitality, and mood also improves therewith, now still adheres to taking daily With often participation outdoor sports in addition, entire people youthens vibrant.Effect of follow-up visit by telephone after 2 months, insomnia do not occur again, It is discontinued.
Case 2
Pacifying certain, female 20 years old, has a sleepless night 5 years, and with dizziness, vomiting, body is cold, it trembles, fatigue, dimly red tongue, whitish tongue, wiry and rolling pulse. The drug therapy of 2 preparations through the embodiment of the present invention, the state of an illness is improved after 20 days, gather colour, and night, which sleeps, to improve, bitter taste, tongue Matter is red, whitish tongue, and deep wiry pulse is sliding;It has a sleepless night and disappears after continual cure 40 days, red tongue body, whitish tongue, wiry and rolling pulse.Effect of follow-up visit by telephone after 2 months, Insomnia does not occur again, has been discontinued.
Case 3
Zhang, female 43 years old, have a sleepless night 5 months, can fall asleep, sleep daily 2-3 hours after medication (zopiclone), and eye is dry, tongue Matter is dark, whitish tongue, veins string.The drug therapy of 3 preparations through the embodiment of the present invention, the state of an illness is improved after 15 days, gather colour, is lost It sleeps and mitigates, dry is bitter, and the tongue nature stasis of blood is dark, and whitish tongue is greasy dry, wiry and rolling pulse.It has a sleepless night and is obviously improved after continual cure 40 days, dark tongue quality, body omits Greatly, whitish tongue is greasy, veins string.Effect of follow-up visit by telephone after 2 months, insomnia do not occur again, have been discontinued.

Claims (3)

1. a kind of Chinese medicine for treating insomnia, it is characterised in that be following drug by ratio of weight and the number of copies made of:
Semen ziziphi spinosae 15 ~ 30, the seed of Oriental arborvitae 5 ~ 10, Radix Polygalae 3 ~ 6, cortex albiziae 8 ~ 14, the vine of multiflower knotweed 9 ~ 15, lily 15 ~ 20, keel 10 ~ 15, Amber 1.5 ~ 5, mother-of-pearl 15 ~ 25, rhizoma corydalis 1.5 ~ 5, ganoderma lucidum 10 ~ 15, lotus seeds 5 ~ 10, jujube 5 ~ 10, dried longan 5 ~ 10, bee Honey 20 ~ 30.
2. a kind of Chinese medicine for treating insomnia according to claim 1, it is characterised in that be by following drug in parts by weight Than manufactured:
Semen ziziphi spinosae 20, the seed of Oriental arborvitae 8, Radix Polygalae 4, cortex albiziae 12, the vine of multiflower knotweed 13, lily 17, keel 13, amber 3, mother-of-pearl 20 prolong Hu rope 3, ganoderma lucidum 12, lotus seeds 7, jujube 7, dried longan 7, honey 25.
3. a kind of preparation method of Chinese medicine for treating insomnia according to claim 1 or 2, comprising the following steps:
Each herbal medicine is weighed according to the above ratio, removes impurity, the decocting of 3 ~ 5 times of doses is added in the other medicines except honey Clothes, fried 3 times, honey is added in fried completion in 60 ~ 120 minutes every time, collecting decoction to obtain the final product.
CN201510308690.1A 2015-06-09 2015-06-09 A kind of Chinese medicine that treating insomnia and preparation method Expired - Fee Related CN104873745B (en)

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CN107536991A (en) * 2016-06-28 2018-01-05 西安交通大学第附属医院 A kind of compound medicine for treating insomnia and preparation method thereof
CN107375729A (en) * 2017-06-30 2017-11-24 禹州市合同泰药业有限公司 A kind of prepared slices of Chinese crude drugs for treating insomnia and preparation method thereof
EP4110363A1 (en) * 2020-02-26 2023-01-04 Industrial Technology Research Institute Composition for modulating intestinal permeability and/or treating and/or preventing leaky gut related diseases, and method for modulating intestinal permeability and/or treating and/or preventing leaky gut related diseases
JP7287937B2 (en) * 2020-02-26 2023-06-06 財團法人工業技術研究院 Composition used for regulation of intestinal permeability and/or treatment and/or prevention of intestinal wall leakage-related diseases
US11701399B2 (en) 2020-02-26 2023-07-18 Industrial Technology Research Institute Composition for modulating intestinal permeability and/or treating and/or preventing leaky gut related diseases, and method for modulating intestinal permeability and/or treating and/or preventing leaky gut related diseases
CN111759921B (en) * 2020-08-27 2021-10-15 段素社 Traditional Chinese medicine decoction for treating insomnia

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CN1528402A (en) * 2003-10-13 2004-09-15 张华贵 Tonic soporific liquid
CN101053433A (en) * 2007-04-30 2007-10-17 陈江 Mind-easing sedative beverage
CN104666836A (en) * 2013-11-29 2015-06-03 陕西康乐中医药养生研究院 Traditional Chinese medicine for relieving insomnia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1528402A (en) * 2003-10-13 2004-09-15 张华贵 Tonic soporific liquid
CN101053433A (en) * 2007-04-30 2007-10-17 陈江 Mind-easing sedative beverage
CN104666836A (en) * 2013-11-29 2015-06-03 陕西康乐中医药养生研究院 Traditional Chinese medicine for relieving insomnia

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