CN104547556A - Traditional Chinese medicine preparation for treating pediatric epilepsy and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating pediatric epilepsy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating pediatric epilepsy. The traditional Chinese medicine preparation consists of the following raw materials in parts by weight: 3-9 parts of radix ligustici sinensis, 15-30 parts of elaeagnus angustifolia, 3-6 parts of ferula asafetida, 9-15 parts of rhizoma polygonati, 1.5-9 parts of liquorice, 9-27 parts of radix acanthopanacis semticosi, 6-15 parts of semen nelumbinis, 6-20 parts of mulberries, 6-15 parts of Chinese dates, 9-12 parts of hawthorns, 1-3 pats of stigma croci, 6-12 parts of lilium brownii and 5-10 parts of bombyx batryticatus. The invention further discloses a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation for treating pediatric epilepsy is a pure traditional Chinese medicine preparation which is remarkable in curative effect and free of obvious toxic and side effects, can be used for overcoming the problems of relatively high cost due to clinic application of drugs such as carbamazepine and zonisamide tablets at present and relatively large side effects to infant patients due to long-term application, and has the advantages of being quick in effect, definite in curative effect, wide in drug resource and low in cost.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of children epilepsy and preparation method thereof.
Background technology
" epilepsy " or " epilepsy " that namely epilepsy is commonly called as, is the electric discharge of cerebral neuron paroxysmal abnormality, causes a kind of chronic disease of of short duration cerebral disorder.Due to the initial position of paradoxical discharge and the difference of transfer mode, the complicated clinical manifestation of epilepsy is various, can show as paroxysmal movement, sensation, autonomic nerve, consciousness and mental disorder.Epilepsy is found in all age group.Epilepsy in childhood sickness rate is comparatively grown up high, and with advancing age, epilepsy invasion rate decreases.Entering the geratic period (after 65 years old) increases due to cerebrovascular, senile dementia and neurodegenerative diseases, and epilepsy invasion rate is shown in rising again.The pathogenesis of epilepsy is very complicated.Imbalance between central nervous system stimulant and suppression causes epilepsy, and it is main relevant with the change of ion channel neurotransmitter and neurogliocyte.
Because the physiological feature of child is different from adult, nervous function as child is not yet sound, cerebral cortex goes back imperfection to infracortical suppression, dynamic stereotype fails firmly to set up and process of intercentral inhibition goes down, therefore, children's just easily causes strong reaction for comparatively pinprick, and the impact of undesirable element is responsive especially especially to external world.Add the change of epineural, so epilepsy in childhood is different with adult in some aspects.Therefore, when treatment children epilepsy, select the medicine little to brain negative effect, multiple Western medicine should not be applied simultaneously as far as possible, general with a kind of, is no more than at most two kinds.Though western medicine and medical practitioners is controlling the advantage having it in epilepsy, excessively strong inhibitory action can damage cerebral nerve function, has obvious toxic-side effects.As carbamazepine, epilepsy amine etc., generally thoroughly can not effect a radical cure epilepsy, and side effect greatly, easily produce drug dependence, easily cause the side effect such as spirit depressing, dysnoesia.In addition, informal dress epilepsy Western medicine, easily causes drug resistance, wants to keep certain curative effect just must increase dosage, can cause more major injury.
Summary of the invention
For above-mentioned prior art, the object of this invention is to provide a kind of Chinese medicine preparation for the treatment of children epilepsy, rapid-action, drug effect is definite, toxic and side effects is low, infant can safety clothes use.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine preparation of children epilepsy.
The present invention is achieved by the following technical solutions:
Treat a Chinese medicine preparation for children epilepsy, be made up of the crude drug of following weight portion:
Rhizoma Ligustici 3 ~ 9 parts, 15 ~ 30 parts, Fructus Elaeagni Angustifoliae, Resina Ferulae 3 ~ 6 parts, Rhizoma Polygonati 9 ~ 15 parts, 1.5 ~ 9 parts, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 9 ~ 27 parts, 6 ~ 15 parts, Semen Nelumbinis, Fructus Mori 6 ~ 20 parts, 6 ~ 15 parts, Fructus Jujubae, Fructus Crataegi 9 ~ 12 parts, Stigma Croci 1 ~ 3 part, Bulbus Lilii 6 ~ 12 parts, Bombyx Batryticatus 5 ~ 10 parts.
The Chinese medicine preparation for the treatment of children epilepsy of the present invention, preferred prescription is:
Rhizoma Ligustici 6 parts, 22 parts, Fructus Elaeagni Angustifoliae, Resina Ferulae 5 parts, Rhizoma Polygonati 12 parts, 6 parts, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 18 parts, 11 parts, Semen Nelumbinis, Fructus Mori 13 parts, 10 parts, Fructus Jujubae, Fructus Crataegi 11 parts, Stigma Croci 2 parts, Bulbus Lilii 9 parts, Bombyx Batryticatus 7 parts.
Formula of the present invention is according to China theory of TCM, in conjunction with inventor's clinical research for many years, the macroscopic syndrome of Chinese medicine opinion is controlled and the Empirical formula that draws in the refined diagnosis Technology application of modern medicine to clinical experimentation.According to theory of Chinese medical science, in children epilepsy, the spleen being the source of producing phlegm, dysfunction of the spleen in transportation, stops humidogene expectorant, then accumulation and obstruction of sputum, wheezing sound in the throat, and mouth is spat foam; Liver opening at eye, irritability is strongly fragrant, therefore stares at staring eyes, twitches not very, or without tic; Stagnation of QI expectorant is tied, and thinking is covered in resistance, then in a certain state of delirium, absentminded, dementia and idiocy; Contain in phlegm-damp, thus white and greasy fur, stringy and rolling pulse.For the pathogeny of children epilepsy, carry out dialectical composition of prescription, the negative and positive basing oneself upon internal organs regulate, to reach the object for the treatment of both the principal and secondary aspects of a disease.
In medicament composing prescription, Rhizoma Ligustici, Fructus Elaeagni Angustifoliae, Resina Ferulae, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Semen Nelumbinis, Fructus Jujubae, Fructus Crataegi, Stigma Croci, Bulbus Lilii, Bombyx Batryticatus 12 taste medical material are the kind that " Chinese Pharmacopoeia " 2010 version () is recorded, every regulation that its quality is relevant under all meeting each kind item; Fructus Mori are the kind that " Shandong medicinal plants " (Shandong science tech publishing house, version in 1998) is recorded, every regulation that its quality is relevant under all meeting each kind item.
Wherein: Rhizoma Ligustici: pungent, temperature; Dispel the wind, cold expelling, dehumidifying, pain relieving, for anemofrigid cold, mountain peak top pain, rheumatism podomere numbness lead to.
Fructus Elaeagni Angustifoliae: sour, micro-sweet, cool; Invigorating the spleen to arrest diarrhea, strong, calm, regulating menstruation; Cure mainly stomachache, diarrhoea, health vanity, insomnia, cough due to lung-heat, dyspepsia.
Resina Ferulae: sweet, bitter, temperature; Warming the lung for resolving phlegm, lowering the adverse-rising QI to subdue asthma, expelling wind and removing dampness, promoting blood circulation and detumescence, diuresis; For cough, asthma, lithangiuria, nephritis, chronic rheumatic arthritis, pharyngolaryngitis.
Rhizoma Polygonati: sweet is flat; Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying, quench one's thirst for weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat.
Radix Glycyrrhizae: sweet, flat; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, wrist abdomen, the anxious pain of extremity contraction, too fat to move sore, cushion toxicity, strong.
Radix Et Caulis Acanthopanacis Senticosi: pungent, micro-hardship, temperature; Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; , inappetence, soreness of waist and knee joint, insomnia and dreamful sleep weak for deficiency of spleen-YANG and kidneyYANG, body void.
Semen Nelumbinis: sweet, puckery are flat; Spleen antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart; For insufficiency of the spleen chronic diarrhea, seminal emission leukorrhagia, palpitation and insomnia
Fructus Mori: YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, intestine moistening is dry.
Fructus Jujubae: sweet, temperature; Return spleen, stomach, heart channel; Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind; For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Fructus Crataegi: sour, sweet, tepor; Return spleen, stomach, Liver Channel; Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, changes turbid blood fat reducing; For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipemia.
Stigma Croci: sweet is flat; GUIXIN, Liver Channel; Blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization; For amenorrhea and mass in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.
Bulbus Lilii: sweet, cold; GUIXIN, lung meridian; Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization; For deficiency of YIN cough caused by dryness, chronic cough hemoptysis, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.
Bombyx Batryticatus: salty, pungent is flat; Return liver, lung, stomach warp; Endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, dissipating phlegm and resolving masses; For liver-wind folder expectorant, infantile convulsion is twitched, acute infantile convulsion, tetanus, middle air port
, headache due to pathogenic wind-heat, conjunctival congestion pharyngalgia, rubella pruritus, maxillofacial sore mumps.
In medicament composing prescription of the present invention, each drug component is through dialectical compatibility, and in drug action, mutually assistant helps, play replenishing QI to invigorate the spleen altogether, the resolving depression that eliminates the phlegm, clearing away heart-fire for tranquillization, effect of helping digestion, fundamentally treating both the principal and secondary aspects of a disease is realized to children epilepsy.
Chinese medicine preparation of the present invention can adopt following methods to prepare:
(1) take each Chinese medicinal components by parts by weight in prescription, Bulbus Lilii, Stigma Croci 2 taste medicine be dry, pulverize, cross 200-300 mesh sieve, obtain medicinal powder, for subsequent use;
(2) by Rhizoma Ligustici, Fructus Elaeagni Angustifoliae, Resina Ferulae, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Semen Nelumbinis, Fructus Mori, Fructus Jujubae, Fructus Crataegi, the mixing of Bombyx Batryticatus 11 taste medicine, soak by water 2 times, adds the water of 8-10 times amount for the first time, decocts 2-4 hour; Second time adds the water of 6-8 times amount, and decoct 1-2 hour, merge the decoction liquor of twice and filter, filtrate reduced in volume, recording relative density when being concentrated into 60 DEG C is 1.15-1.25, obtains extractum;
(3) the extractum mixing that medicinal powder step (1) obtained and step (2) obtain, dry, to obtain final product.
The Chinese medicine preparation for the treatment of children epilepsy of the present invention can make the dosage form medically approved, according to a conventional method as capsule, tablet or granule.
Beneficial effect of the present invention:
(1) Chinese medicine preparation for the treatment of children epilepsy of the present invention is pure Chinese medicinal preparation, evident in efficacy, without obvious toxic-side effects; Overcome and use the medicine such as carbamazepine, zonisamide tablet in a large number clinically at present, cost is higher, the problem that life-time service is larger to infant patient's side effect;
(2) instant effect, determined curative effect, medicine source is extensive, with low cost.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, should be noted that following explanation is only to explain the present invention, not limits its content.
Embodiment 1: a kind of Chinese medicine preparation for the treatment of children epilepsy
[prescription] Rhizoma Ligustici 6 parts, 22 parts, Fructus Elaeagni Angustifoliae, Resina Ferulae 5 parts, Rhizoma Polygonati 12 parts, 6 parts, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 18 parts, 11 parts, Semen Nelumbinis, Fructus Mori 13 parts, 10 parts, Fructus Jujubae, Fructus Crataegi 11 parts, Stigma Croci 2 parts, Bulbus Lilii 9 parts, Bombyx Batryticatus 7 parts.
[method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, Bulbus Lilii, Stigma Croci 2 taste medicine be dry, pulverize, and crosses 200-300 mesh sieve, obtains medicinal powder, for subsequent use;
(2) by Rhizoma Ligustici, Fructus Elaeagni Angustifoliae, Resina Ferulae, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Semen Nelumbinis, Fructus Mori, Fructus Jujubae, Fructus Crataegi, the mixing of Bombyx Batryticatus 11 taste medicine, soak by water 2 times, adds the water of 9 times amount for the first time, decocts 3 hours; Second time adds the water of 7 times amount, and decoct 1.5 hours, merge the decoction liquor of twice and filter, filtrate reduced in volume, recording relative density when being concentrated into 60 DEG C is 1.20, obtains extractum;
(3) the extractum mixing that medicinal powder step (1) obtained and step (2) obtain, dry, to obtain final product.
The Chinese medicine preparation for the treatment of children epilepsy of the present invention can make the granule medically approved according to a conventional method, and the specification of granule is 3.5g/ bag, and usage and dosage is: every day 2 times, each 1 bag.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of children epilepsy
[prescription] Rhizoma Ligustici 3 parts, 15 parts, Fructus Elaeagni Angustifoliae, Resina Ferulae 3 parts, Rhizoma Polygonati 9 parts, 1.5 parts, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 9 parts, 6 parts, Semen Nelumbinis, Fructus Mori 6 parts, 6 parts, Fructus Jujubae, Fructus Crataegi 9 parts, Stigma Croci 1 part, Bulbus Lilii 6 parts, Bombyx Batryticatus 5 parts.
[method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, Bulbus Lilii, Stigma Croci 2 taste medicine be dry, pulverize, and crosses 200-300 mesh sieve, obtains medicinal powder, for subsequent use;
(2) by Rhizoma Ligustici, Fructus Elaeagni Angustifoliae, Resina Ferulae, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Semen Nelumbinis, Fructus Mori, Fructus Jujubae, Fructus Crataegi, the mixing of Bombyx Batryticatus 11 taste medicine, soak by water 2 times, adds the water of 8 times amount for the first time, decocts 2 hours; Second time adds the water of 6 times amount, and decoct 1 hour, merge the decoction liquor of twice and filter, filtrate reduced in volume, recording relative density when being concentrated into 60 DEG C is 1.15, obtains extractum;
(3) the extractum mixing that medicinal powder step (1) obtained and step (2) obtain, dry, to obtain final product.
The Chinese medicine preparation for the treatment of children epilepsy of the present invention can make the granule medically approved according to a conventional method, and the specification of granule is 3.5g/ bag, and usage and dosage is: every day 2 times, each 1 bag.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of children epilepsy
[prescription] Rhizoma Ligustici 9 parts, 30 parts, Fructus Elaeagni Angustifoliae, Resina Ferulae 6 parts, Rhizoma Polygonati 15 parts, 9 parts, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 27 parts, 15 parts, Semen Nelumbinis, Fructus Mori 20 parts, 15 parts, Fructus Jujubae, Fructus Crataegi 12 parts, Stigma Croci 3 parts, Bulbus Lilii 12 parts, Bombyx Batryticatus 10 parts.
[method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, Bulbus Lilii, Stigma Croci 2 taste medicine be dry, pulverize, and crosses 200-300 mesh sieve, obtains medicinal powder, for subsequent use;
(2) by Rhizoma Ligustici, Fructus Elaeagni Angustifoliae, Resina Ferulae, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Semen Nelumbinis, Fructus Mori, Fructus Jujubae, Fructus Crataegi, the mixing of Bombyx Batryticatus 11 taste medicine, soak by water 2 times, adds the water of 10 times amount for the first time, decocts 4 hours; Second time adds the water of 8 times amount, and decoct 2 hours, merge the decoction liquor of twice and filter, filtrate reduced in volume, recording relative density when being concentrated into 60 DEG C is 1.25, obtains extractum;
(3) the extractum mixing that medicinal powder step (1) obtained and step (2) obtain, dry, to obtain final product.
The Chinese medicine preparation for the treatment of children epilepsy of the present invention can make the granule medically approved according to a conventional method, and the specification of granule is 3.5g/ bag, and usage and dosage is: every day 2 times, each 1 bag.
Clinical data
One, physical data:
Chinese medicine preparation of the present invention be applied to clinical observation case 156 example, wherein, male children patient 72 example, Female Children patient be 84 example, age 1-12 year.
Two, diagnostic criteria and criterion of therapeutical effect:
(1) diagnostic criteria: according to " epileptics guideline of clinical investigations treated by Chinese medicine (new drug) ", the clinical manifestation of children epilepsy is: unexpected tumbling down during outbreak, in a certain state of delirium, accumulation and obstruction of sputum, wheezing sound in the throat, mouth is spat foam, twitches not very, or absentminded and without tic, stare at staring eyes, dementia and idiocy, white and greasy fur, stringy and rolling pulse.
(2) curative effect determinate standard
Curative effect determinate standard is as follows:
1. effective: outbreak controls completely or seizure frequency reduces more than 90%;
2. effective: seizure frequency reduces 60% ~ 90%;
3. invalid: clinical symptoms and sign are without improvement.
Three, clinical testing procedure:
(1) case grouping
Selected case history is divided at random test group 78 example, matched group 78 example.
(2) dosage regimen
Test group takes granule prepared by the embodiment of the present invention 1, oral, every day 2 times, each 1 bag; Matched group takes Carbamazepine Tablets (Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd., the accurate word of traditional Chinese medicines: H31020443), oral, each 0.2g, 3 times on the 1st; Within 30 days, be a course for the treatment of, observe 3 courses for the treatment of.
Four, clinical treatment outcome and model case
(1) clinical therapeutic efficacy
The therapeutic effect of test group and matched group is in table 1.Result shows, the overall clinical efficacy rate of test group is 94.9%, is better than matched group.Show Chinese medicine composition determined curative effect of the present invention.
Table 1. test group and matched group comparitive study
(2) model case:
Case 1, Lee, female, 6 years old.Whole-body muscle spasm, loss of consciousness, two are turned over, spits out white foams, larynx shouts a shout, and tongue sometimes can be had to bite and incontinence of urination and defecation.Outbreak continues 1-5 minute or longer, and outbreak proceeds to lethargy after stopping, and often tells headache, malaise, absentminded after waking up.Be diagnosed as epilepsy in childhood through tcm diagnosis, after 2 courses for the treatment of of Chinese medicine preparation adopting the embodiment of the present invention 1 to prepare, symptom is clearly better, and after continuing to take 2 courses for the treatment of, cures, follows up a case by regular visits to 1 year, have no recurrence.
Case 2, Zhao so-and-so, man, 3 years old, body part clonospasm, show effect every day 3 ~ 4 times, each 5 ~ 15 minutes, be diagnosed as epilepsy in childhood through tcm diagnosis, after 1 course for the treatment of of Chinese medicine preparation adopting the embodiment of the present invention 1 to prepare, symptom obviously alleviates, and after continuing to take 1 course for the treatment of, cures, follow up a case by regular visits to 1 year, have no recurrence.
Claims (3)
1. treat a Chinese medicine preparation for children epilepsy, it is characterized in that, be made up of the crude drug of following weight portion:
Rhizoma Ligustici 3 ~ 9 parts, 15 ~ 30 parts, Fructus Elaeagni Angustifoliae, Resina Ferulae 3 ~ 6 parts, Rhizoma Polygonati 9 ~ 15 parts, 1.5 ~ 9 parts, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 9 ~ 27 parts, 6 ~ 15 parts, Semen Nelumbinis, Fructus Mori 6 ~ 20 parts, 6 ~ 15 parts, Fructus Jujubae, Fructus Crataegi 9 ~ 12 parts, Stigma Croci 1 ~ 3 part, Bulbus Lilii 6 ~ 12 parts, Bombyx Batryticatus 5 ~ 10 parts.
2. a kind of Chinese medicine preparation for the treatment of children epilepsy as claimed in claim 1, is characterized in that, be made up of the crude drug of following weight portion:
Rhizoma Ligustici 6 parts, 22 parts, Fructus Elaeagni Angustifoliae, Resina Ferulae 5 parts, Rhizoma Polygonati 12 parts, 6 parts, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 18 parts, 11 parts, Semen Nelumbinis, Fructus Mori 13 parts, 10 parts, Fructus Jujubae, Fructus Crataegi 11 parts, Stigma Croci 2 parts, Bulbus Lilii 9 parts, Bombyx Batryticatus 7 parts.
3. the Chinese medicine preparation preparation method for the treatment of children epilepsy as claimed in claim 1 or 2, is characterized in that, comprise the steps:
(1) take each Chinese medicinal components by parts by weight in prescription, Bulbus Lilii, Stigma Croci 2 taste medicine be dry, pulverize, cross 200-300 mesh sieve, obtain medicinal powder, for subsequent use;
(2) by Rhizoma Ligustici, Fructus Elaeagni Angustifoliae, Resina Ferulae, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Semen Nelumbinis, Fructus Mori, Fructus Jujubae, Fructus Crataegi, the mixing of Bombyx Batryticatus 11 taste medicine, soak by water 2 times, adds the water of 8-10 times amount for the first time, decocts 2-4 hour; Second time adds the water of 6-8 times amount, and decoct 1-2 hour, merge the decoction liquor of twice and filter, filtrate reduced in volume, recording relative density when being concentrated into 60 DEG C is 1.15-1.25, obtains extractum;
(3) the extractum mixing that medicinal powder step (1) obtained and step (2) obtain, dry, to obtain final product.
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| CN104857247A (en) * | 2015-06-04 | 2015-08-26 | 赵景岩 | Traditional Chinese medicine for treating spleen-deficiency and phlegm-damp type pediatric epilepsy, and preparation method thereof |
| CN111068002A (en) * | 2019-12-16 | 2020-04-28 | 付友彬 | A Chinese medicinal composition for treating epilepsy, and its preparation method |
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| JP2010095545A (en) * | 2010-02-01 | 2010-04-30 | Teikoku Seiyaku Co Ltd | Method of keeping cinnamic aldehyde content |
| CN102949581A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Pure traditional Chinese medicine composition used for easing epilepsy and calming nerves and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857247A (en) * | 2015-06-04 | 2015-08-26 | 赵景岩 | Traditional Chinese medicine for treating spleen-deficiency and phlegm-damp type pediatric epilepsy, and preparation method thereof |
| CN111068002A (en) * | 2019-12-16 | 2020-04-28 | 付友彬 | A Chinese medicinal composition for treating epilepsy, and its preparation method |
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