CN105796962A - Nerve soothing pharmaceutical composition and preparation method thereof - Google Patents

Nerve soothing pharmaceutical composition and preparation method thereof Download PDF

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CN105796962A
CN105796962A CN201610224446.1A CN201610224446A CN105796962A CN 105796962 A CN105796962 A CN 105796962A CN 201610224446 A CN201610224446 A CN 201610224446A CN 105796962 A CN105796962 A CN 105796962A
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parts
pharmaceutical composition
powder
semen
draconis
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林淑录
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Abstract

The invention provides nerve soothing pharmaceutical composition. The pharmaceutical composition comprises following raw materials: 5-10 parts of cinnabar, 5-10 parts of magnetite, 1-3 parts of dragon bones, 4-8 parts of dens draconis, 1-5 parts of oysters, 1-3 parts of amber, 1-3 parts of pearls, 4-8 parts of spine date seed, 5-10 parts of Chinese arborvitae kernel, 10-15 parts of thinleaf milkwort root, 4-9 parts of tuber fleeceflower stem, 5-10 parts of cortex albiziae, 4-9 parts of wheat, 1-5 parts of husked sorghum, 1-3 parts of Valerian root, 40-50 parts of charcoal, 10-15 parts of ganoderma lucidum, 3-5 parts of Coptis chinensis, 1-3 parts of cape jasmine fruit, 5-10 parts of bezoar and 5-10 parts of lotus plumule. A preparation method of the pharmaceutical composition comprises the following steps: the spine date seed, the Chinese arborvitae kernel, the thinleaf milkwort root, the tuber fleeceflower stem, the cortex albiziae, the wheat, the husked sorghum, the Valerian root, the ganoderma lucidum, the Coptis chinensis, the cape jasmine fruit, the bezoar and the lotus plumule are ground and extracted, an extraction liquid is concentrated and mixed with the charcoal, the cinnabar, the magnetite, the dragon bones, the dens draconis, the oysters, the amber and the pearls, a mixture is dried and ground, and a medicine bag is prepared. The nerve soothing pharmaceutical composition has the characteristics that the raw materials are pure natural, chemical additives are avoided and preparation is simple; the prepared pharmaceutical composition can soothe nerves, guide vital qi of a human body and adjust organism balance.

Description

A kind of pharmaceutical composition for soothing nerves and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for soothing nerves and preparation method thereof.
Background technology
Along with developing rapidly of society now, people's rhythm of life accelerates, and modern's life stress is big, can produce the phenomenon of insomnia, and insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep.Also known as DIMS, cause that difficulty falling asleep, Depth of sleep or frequency be too short for a variety of causes, early awakening and the length of one's sleep not enough or of poor quality etc., be a kind of commonly encountered diseases.The harm of insomnia is apparent from, and from short-term effect, not having enough sleep, what directly affect is work and the study of second day, and lethargy is tired out unable, emotional lability, absent minded.And from the point of long-term development, endanger huge and far-reaching especially: Most patients chronic insomnia, more sleepy more be can't fall asleep, more anxious more can not sleep any more, easily causes anxiety neurosis；Have a sleepless night for a lot of people is all the possibility bringing out certain potential disease simultaneously, such as autonomic nervous dysfunction, is susceptible to suffer from function of nervous system hyperfunction etc., trick heart hyperhidrosis, cardiopalmus, rapid heart beat occur, breathe anxious resistance, muscle contraction, trembles, urgent micturition frequent micturition, chest has constriction, abdominal distention and rush down, pharyngeal hinder sense, hyperhidrosis, the extremity symptom such as do not have power numb；The social nature of man be will also result in great harm by insomnia, owing to being absorbed in the worry for sleep and fear for a long time, people can become suspicious, sensitive, irritability, and it is suitable self-doubt, these certainly will affect its inter personal contact of each side in family and work, thus producing feeling of lonely, sense of defeat.
Doctor trained in Western medicine, for the treatment of insomnia, mostly adopts hypnotic sedative class medicine, but this type of medicine has certain risk, and the prescription of traditional Chinese medicine in treating insomnia is then comparatively various, and once withdrawal, then easily recurs.
Therefore in the case of for the frequent neurasthenia of modern, insomnia, develop the sustainable transquilizing medicine composition that a kind of applicable modern uses, simultaneously to human body without health risk, it is possible to fundamentally solve the symptom of neurasthenia, insomnia, it is the encountered a great problems of those skilled in the art.
Summary of the invention
In order to overcome above-mentioned prior art defect, it is an object of the invention to provide pharmaceutical composition for soothing nerves and preparation method thereof, the Chinese crude drug for the treatment of neurasthenia, insomnia is inserted in medicated pillow or places the head of a bed, in conjunction with Chinese medicine combination principle on the basis of ancient prescription, select medicine, nurse one's health total balance of the body by medicine nature slow release, efficiently solve the problems referred to above.
In order to solve above-mentioned technical problem, the present invention takes following technical scheme:
A kind of pharmaceutical composition for soothing nerves, including Cinnabaris, Magnetitum, Os Draconis, Dens Draconis, Concha Ostreae, succinum, Margarita, Semen Ziziphi Spinosae, Semen Platycladi, Radix Polygalae, Caulis Polygoni Multiflori, Herba Albiziae, Semen Tritici aestivi, Sorghum vulgare Pers., Rhizoma et radix valerianae, Linesless charcoal, Ganoderma, Rhizoma Coptidis, Fructus Gardeniae, Calculus Bovis, Plumula Nelumbinis；Described pharmaceutical composition includes following weight parts composition: 5～10 parts of Cinnabaris, Magnetitum 5～10 parts, Os Draconis 1～3 part, Dens Draconis 4～8 parts, Concha Ostreae 1～5 part, succinum 1～3 part, Margarita 1～3 part, Semen Ziziphi Spinosae 4～8 parts, Semen Platycladi 5～10 parts, Radix Polygalae 10～15 parts, Caulis Polygoni Multiflori 4～9 parts, Cortex Albiziae 5～10 parts, Semen Tritici aestivi 4～9 parts, Sorghum vulgare Pers. 1～5 part, Rhizoma et radix valerianae 1～3 part, 40～50 parts of Linesless charcoal, Ganoderma 10～15 parts, Rhizoma Coptidis 3～5 parts, Fructus Gardeniae 1～3 part, Calculus Bovis 5～10 parts.
A kind of pharmaceutical composition for soothing nerves, also includes Plumula Nelumbinis 5～10 parts.
Further, described pharmaceutical composition for soothing nerves optimum weight portion consists of: 8 parts of Cinnabaris, Magnetitum 9 parts, Os Draconis 1 part, Dens Draconis 7 parts, Concha Ostreae 2 parts, succinum 3 parts, Margarita 2 parts, Semen Ziziphi Spinosae 4 parts, Semen Platycladi 10 parts, Radix Polygalae 11 parts, Caulis Polygoni Multiflori 6 parts, Cortex Albiziae 8 parts, Semen Tritici aestivi 9 parts, Sorghum vulgare Pers. 5 parts, Rhizoma et radix valerianae 3 parts, 47 parts of Linesless charcoal, Ganoderma 14 parts, Rhizoma Coptidis 4 parts, Fructus Gardeniae 2 parts, Calculus Bovis 6 parts, Plumula Nelumbinis 7 parts.
Wherein, the primarily serving the purpose of of aforementioned pharmaceutical compositions composition:
Cinnabaris sweet in the mouth, cold nature；Poisonous, GUIXIN warp, can clear away heart-fire relieving convulsion, removing toxic substances of calming the nerves.For palpitation and being susceptible to fright, insomnia and dreamful sleep, epilepsy is gone mad, infantile convulsion, blurring of vision, aphtha, sore throat, sore swollen toxin.
Magnetitum salty in the mouth, property, return liver, the heart, kidney channel, energy suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.For having a dizzy spell, blurring of vision, Hiccough and deaf, palpitation with fear insomnia, asthma of suffering from a deficiency of the kidney.
Os Draconis sweet in the mouth, puckery, property is put down；There are calmness, arresting sweating arresting seminal emission, promoting tissue regeneration and ulcer healing.For neurasthenia, cardiopalmus, insomnia, dreaminess, spontaneous perspiration, night sweat, seminal emission, the enuresis, metrorrhagia, leukorrhagia；External control skin infection for a long time burst do not hold back.
Dens Draconis puckery, sweet, cool in nature, GUIXIN, Liver Channel, tranquillizing the mind by relieving convulsion；Clearing heat and relieving fidgetness.Main infantile convulsion；Demented；Severe palpitation；Insomnia and dreamful sleep；Fever of the body is vexed.
Concha Ostreae salty in the mouth, cold nature, return liver, gallbladder, kidney channel, energy tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, metrorrhagia and leukorrhagia of passing out semen, acid regurgitation of having a stomachache.
Succinum sweet in the mouth, property is put down, nontoxic；GUIXIN, liver, small intestinal, bladder, lung, spleen channel, can tranquillizing the mind by relieving convulsion, dissipating blood stasis hemostasis, relieving stranguria by diuresis, removing nebula improving eyesight, main palpitation with fear insomnia, infantile convulsion epilepsy, stranguria with blood hematuria, amenorrhea due to stagnation of blood, puerperal the stagnant stomachache of the stasis of blood, lump in the abdomen, order give birth to hide from view, carbuncle sore tumefacting virus.
Margarita salty in the mouth, cold in nature, return liver, heart channel, energy suppressing the hyperactive liver and subsiding YANG, improving eyesight of calming the frightened.For dizziness of having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.
Semen Ziziphi Spinosae sweet in the mouth, acid, property is put down, and returns liver, gallbladder, heart channel, energy tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, dreaminess of palpitating with fear, body void hyperhidrosis, Tianjin wound is thirsty.
Semen Platycladi is sweet, and property is put down, GUIXIN, kidney, large intestine channel, energy tranquilizing by nourishing the heart, hidroschesis, intestine moistening.Have a sleepless night for fidgets due to deficiency, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.
Radix Polygalae bitter in the mouth, pungent, warm in nature, GUIXIN, kidney, lung meridian, Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Caulis Polygoni Multiflori sweet in the mouth, micro-hardship, property put down, GUIXIN, Liver Channel, can tranquilizing by nourishing the heart, dispel the wind, dredging collateral.Main insomnia；Dreaminess；Blood deficiency general pain；Numbness of the skin；Rheumatic arthralgia；Rubella pruritus.
Cortex Albiziae sweet in the mouth, property are flat, GUIXIN, Liver Channel, resolving depression of calming the nerves, eliminating carbuncle of invigorating blood circulation.Main irritability；Melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury.
Semen Tritici aestivi sweet in the mouth, cool in nature, GUIXIN, spleen, kidney channel, can nourish heart, kidney tonifying, heat extraction, quench the thirst.Main hysteria, dysphoria with smothery sensation, quench one's thirst, let out profit, carbuncle, traumatic hemorrhage, scald.
Sorghum vulgare Pers. sweet in the mouth, cold nature, return lung, stomach, large intestine channel, energy expelling wind and removing dampness, stomach function regulating are calmed the nerves, sore of detoxifying, main malaria cold and heat, muscles and bones contraction urgency, dysentery, uneasy sleeping at night, toxic swelling, dermatitis rhus, chilblain, lyssodexis.
Rhizoma et radix valerianae acrid in the mouth, sweet, warm in nature, can calm the nerves, regulate the flow of vital energy, pain relieving.For neurasthenia, insomnia, hysteria, epilepsy, stomach abdominal distention and pain, lumbago and skelalgia, traumatic injury.
Ganoderma sweet in the mouth, property is put down, nontoxic；Return lung, the heart, spleen, kidney channel, can replenishing QI and blood, tranquilizing mind, strengthening the spleen and stomach.Main asthenia, cardiopalmus, insomnia, dizziness, spiritlessness and weakness, chronic cough asthma, coronary heart disease, silicosis, tumor.
Rhizoma Coptidis bitter in the mouth, cold in nature, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, energy heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomitting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle；External treatment eczema, eczema, auditory meatus is suppurated.
Fructus Gardeniae bitter in the mouth, cold in nature, GUIXIN, lung, tri-jiao channel, energy pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles；External treatment bruise pain.
Calculus Bovis sweet in the mouth, cool in nature, GUIXIN, Liver Channel, can clear away heart-fire, eliminating phlegm, have one's ideas straightened out, cool liver, endogenous wind stopping, removing toxic substances.For calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.
Its adsorption of Linesless charcoal, enables pharmaceutical composition slow release.
Wherein, the medicine of above-mentioned interpolation act as:
Plumula Nelumbinis bitter in the mouth, cold in nature, GUIXIN, kidney channel, energy clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, unsmoothing the sperm and stopping bleeding.For heat attacking the pericardium, unconsciousness and delirium, disarmony between the heart and kidney, insomnia seminal emission, heat in blood is spitted blood.
Further object is that the preparation method that described a kind of pharmaceutical composition for soothing nerves is provided, comprise the following steps:
The first step; by described Semen Ziziphi Spinosae 4～8 parts, Semen Platycladi 5～10 parts, Radix Polygalae 10～15 parts, Caulis Polygoni Multiflori 4～9 parts, Cortex Albiziae 5～10 parts, Semen Tritici aestivi 4～9 parts, Sorghum vulgare Pers. 1～5 part, Rhizoma et radix valerianae 1～3 part, Ganoderma 10～15 parts, Rhizoma Coptidis 3～5 parts, Fructus Gardeniae 1～3 part, Calculus Bovis 5～10 parts, Plumula Nelumbinis 5～10 parts; co-grinding, powder is standby；
Second step, by powder extracting in water in the first step, filters, and extracting solution is standby；
3rd step, by 40～50 parts of Linesless charcoal, 5～10 parts of Cinnabaris, Magnetitum 5～10 parts, Os Draconis 1～3 part, Dens Draconis 4～8 parts, Concha Ostreae 1～5 part, succinum 1～3 part, 1～3 part of mix homogeneously of Margarita, is ground into powder；
4th step, is condensed into thick paste by extracting solution heating in second step, and mixes with powder in the 3rd step, be packaged into product after dry, pulverize.；
Further, in the first step, the condition of described co-grinding is: the powder after medicinal mixture pulverizing crosses 10 mesh sieves.
Further, in second step, the condition of described extraction is: powder in (1) is added the water of gross weight 6～9 times, extracts 2～3 hours under 100 DEG C of conditions.
Further, in the third step, the condition of described pulverizing is: the powder after medicinal mixture pulverizing crosses 80 mesh sieves.
Further, in the 4th step, the condition of described heating concentration is: when normal pressure 60 DEG C～70 DEG C, concentrated solution is concentrated into the thick paste that relative density is 1.30～1.35.
Further, in the 4th step, described dry condition is: dry when normal pressure 60 DEG C～70 DEG C.
Further, in the 4th step, the condition of described pulverizing is: the powder after pulverizing crosses 10 mesh sieves.
The invention have the advantage that
The Chinese crude drug for the treatment of neurasthenia, insomnia is inserted in medicated pillow or places the head of a bed, in conjunction with Chinese medicine combination principle on the basis of ancient prescription, select medicine, total balance of the body is nursed one's health by medicine nature slow release, there is raw material pure natural, without chemical addition agent, make simple feature, the pharmaceutical composition of preparation can not only tranquilizing by nourishing the heart, additionally it is possible to adjust function of human body balance, the problem fundamentally solving neurasthenia, insomnia.
Detailed description of the invention
Specific embodiments of the invention given below, are used for the present invention is described in further detail.
Experimental technique in following embodiment, if no special instructions, is conventional method.Medicinal raw material used in following embodiment, reagent material etc., if no special instructions, be commercially available purchase product.
Embodiment 1
A kind of pharmaceutical composition for soothing nerves
Raw material forms: (unit: g)
Cinnabaris 80, Magnetitum 90, Os Draconis 10, Dens Draconis 70, Concha Ostreae 20, succinum 30, Margarita 20, Semen Ziziphi Spinosae 40, Semen Platycladi 100, Radix Polygalae 110, Caulis Polygoni Multiflori 60, Cortex Albiziae 80, Semen Tritici aestivi 90, Sorghum vulgare Pers. 50, Rhizoma et radix valerianae 30, Linesless charcoal 470, Ganoderma 140, Rhizoma Coptidis 40, Fructus Gardeniae 20, Calculus Bovis 60, Plumula Nelumbinis 70.
It is prepared via a method which:
(1) weigh Semen Ziziphi Spinosae, Semen Platycladi, Radix Polygalae, Caulis Polygoni Multiflori, Cortex Albiziae, Semen Tritici aestivi, Sorghum vulgare Pers., Rhizoma et radix valerianae, Ganoderma, Rhizoma Coptidis, Fructus Gardeniae, Calculus Bovis, Plumula Nelumbinis on request, cross 10 mesh sieves after co-grinding, obtain powder 890g.
(2) powder in (1) is added the water of 7.5kg, extract 2.5 hours under 100 DEG C of conditions.
(3) by Cinnabaris, Magnetitum, Os Draconis, Dens Draconis, Concha Ostreae, succinum, Margarita, Linesless charcoal mix homogeneously, it is ground into powder 790g.
(4) by (2) when normal pressure 67 DEG C, concentrated solution is concentrated into the thick paste that relative density is 1.32, and mixes with powder in (3), dry when normal pressure 67 DEG C, obtain solids 924g.
(5) solids in (4) is pulverized, cross 10 mesh sieves, obtain powder 924g, powder is dispensed into Bu Baonei, often wrap 6g, obtain product 154 and wrap.
Embodiment 2
A kind of pharmaceutical composition for soothing nerves
Raw material forms: (unit: g)
Cinnabaris 50, Magnetitum 50, Os Draconis 10, Dens Draconis 40, Concha Ostreae 10, succinum 10, Margarita 10, Semen Ziziphi Spinosae 40, Semen Platycladi 50, Radix Polygalae 100, Caulis Polygoni Multiflori 40, Cortex Albiziae 50, Semen Tritici aestivi 40, Sorghum vulgare Pers. 10, Rhizoma et radix valerianae 10, Linesless charcoal 400, Ganoderma 100, Rhizoma Coptidis 30, Fructus Gardeniae 10, Calculus Bovis 50, Plumula Nelumbinis 50.
It is prepared via a method which:
(1) weigh Semen Ziziphi Spinosae, Semen Platycladi, Radix Polygalae, Caulis Polygoni Multiflori, Cortex Albiziae, Semen Tritici aestivi, Sorghum vulgare Pers., Rhizoma et radix valerianae, Ganoderma, Rhizoma Coptidis, Fructus Gardeniae, Calculus Bovis, Plumula Nelumbinis on request, cross 10 mesh sieves after co-grinding, obtain powder 580g.
(2) powder in (1) is added the water of 3.48kg, extract 2 hours under 100 DEG C of conditions.
(3) by Cinnabaris, Magnetitum, Os Draconis, Dens Draconis, Concha Ostreae, succinum, Margarita, Linesless charcoal mix homogeneously, it is ground into powder 580g.
(4) by (2) when normal pressure 60 DEG C, concentrated solution is concentrated into the thick paste that relative density is 1.30, and mixes with powder in (3), dry when normal pressure 60 DEG C, obtain solids 667g.
(5) solids in (4) is pulverized, cross 10 mesh sieves, obtain powder 666g, powder is dispensed into Bu Baonei, often wrap 6g, obtain product 111 and wrap.
Embodiment 3
A kind of pharmaceutical composition for soothing nerves
Raw material forms: (unit: g)
Cinnabaris 100, Magnetitum 100, Os Draconis 30, Dens Draconis 80, Concha Ostreae 50, succinum 30, Margarita 30, Semen Ziziphi Spinosae 80, Semen Platycladi 100, Radix Polygalae 150, Caulis Polygoni Multiflori 90, Cortex Albiziae 100, Semen Tritici aestivi 90, Sorghum vulgare Pers. 50, Rhizoma et radix valerianae 30, Linesless charcoal 500, Ganoderma 150, Rhizoma Coptidis 50, Fructus Gardeniae 30, Calculus Bovis 100, Plumula Nelumbinis 100.
It is prepared via a method which:
(1) weigh Semen Ziziphi Spinosae, Semen Platycladi, Radix Polygalae, Caulis Polygoni Multiflori, Cortex Albiziae, Semen Tritici aestivi, Sorghum vulgare Pers., Rhizoma et radix valerianae, Ganoderma, Rhizoma Coptidis, Fructus Gardeniae, Calculus Bovis, Plumula Nelumbinis on request, cross 10 mesh sieves after co-grinding, obtain powder 1120g.
(2) powder in (1) is added the water of 10.08kg, extract 3 hours under 100 DEG C of conditions.
(3) by Cinnabaris, Magnetitum, Os Draconis, Dens Draconis, Concha Ostreae, succinum, Margarita, Linesless charcoal mix homogeneously, it is ground into powder 920g.
(4) by (2) when normal pressure 70 DEG C, concentrated solution is concentrated into the thick paste that relative density is 1.30, and mixes with powder in (3), dry when normal pressure 70 DEG C, obtain solids 1088g.
(5) solids in (4) is pulverized, cross 10 mesh sieves, obtain powder 1086g, powder is dispensed into Bu Baonei, often wrap 6g, obtain product 181 and wrap.
Embodiment 4
A kind of pharmaceutical composition for soothing nerves
Raw material forms: (unit: g)
Cinnabaris 75, Magnetitum 75, Os Draconis 20, Dens Draconis 60, Concha Ostreae 30, succinum 20, Margarita 20, Semen Ziziphi Spinosae 60, Semen Platycladi 75, Radix Polygalae 125, Caulis Polygoni Multiflori 65, Cortex Albiziae 75, Semen Tritici aestivi 65, Sorghum vulgare Pers. 30, Rhizoma et radix valerianae 20, Linesless charcoal 450, Ganoderma 125, Rhizoma Coptidis 40, Fructus Gardeniae 20, Calculus Bovis 75, Plumula Nelumbinis 75.
It is prepared via a method which:
(1) weigh Semen Ziziphi Spinosae, Semen Platycladi, Radix Polygalae, Caulis Polygoni Multiflori, Cortex Albiziae, Semen Tritici aestivi, Sorghum vulgare Pers., Rhizoma et radix valerianae, Ganoderma, Rhizoma Coptidis, Fructus Gardeniae, Calculus Bovis, Plumula Nelumbinis on request, cross 10 mesh sieves after co-grinding, obtain powder 850g.
(2) powder in (1) is added the water of 6375g, extract 2.5 hours under 100 DEG C of conditions.
(3) by Cinnabaris, Magnetitum, Os Draconis, Dens Draconis, Concha Ostreae, succinum, Margarita, Linesless charcoal mix homogeneously, it is ground into powder 750g.
(4) by (2) when normal pressure 65 DEG C, concentrated solution is concentrated into the thick paste that relative density is 1.33, and mixes with powder in (3), dry when normal pressure 65 DEG C, obtain solids 880g.
(5) solids in (4) is pulverized, cross 10 mesh sieves, obtain powder 880g, powder is dispensed into Bu Baonei, often wrap 8g, obtain product 110 and wrap.
Embodiment 5
A kind of pharmaceutical composition for soothing nerves
Raw material forms: (unit: g)
Cinnabaris 70, Magnetitum 70, Os Draconis 25, Dens Draconis 65, Concha Ostreae 35, succinum 25, Margarita 25, Semen Ziziphi Spinosae 65, Semen Platycladi 70, Radix Polygalae 120, Caulis Polygoni Multiflori 60, Cortex Albiziae 70, Semen Tritici aestivi 60, Sorghum vulgare Pers. 35, Rhizoma et radix valerianae 25, Linesless charcoal 455, Ganoderma 120, Rhizoma Coptidis 45, Fructus Gardeniae 25, Calculus Bovis 70, Plumula Nelumbinis 70.
It is prepared via a method which:
(1) weigh Semen Ziziphi Spinosae, Semen Platycladi, Radix Polygalae, Caulis Polygoni Multiflori, Cortex Albiziae, Semen Tritici aestivi, Sorghum vulgare Pers., Rhizoma et radix valerianae, Ganoderma, Rhizoma Coptidis, Fructus Gardeniae, Calculus Bovis, Plumula Nelumbinis on request, cross 10 mesh sieves after co-grinding, obtain powder 835g.
(2) powder in (1) is added the water of 6680g, extract 2 hours under 100 DEG C of conditions.
(3) by Cinnabaris, Magnetitum, Os Draconis, Dens Draconis, Concha Ostreae, succinum, Margarita, Linesless charcoal mix homogeneously, it is ground into powder 770g.
(4) by (2) when normal pressure 66 DEG C, concentrated solution is concentrated into the thick paste that relative density is 1.33, and mixes with powder in (3), dry when normal pressure 66 DEG C, obtain solids 896g.
(5) solids in (4) is pulverized, cross 10 mesh sieves, obtain powder 896g, powder is dispensed into Bu Baonei, often wrap 8g, obtain product 112 and wrap.
Experimental example
(1) physical data
200 example neurastheniacs were carried out clinical observation, 20 to 65 years old ages in 2013 by the present inventor so far, and main manifestations is: easily excited, mental easily tired, headache, sleep disorder, secondary anxiety etc..The course of disease at least 3 months, has the feature of recurrent fluctuations or delay, and the every secondary undulation of the state of an illness is how relevant with Nervous and Mental Factors.
(2) Therapeutic Method: with the product of the present embodiment 1, place even, observe situation after 30 days.
(3) efficacy assessment standard
Cure: easily excited under normal circumstances, mental easily tired, headache, sleep disorder, the transference cure such as secondary anxiety, full of vitality, energetic, have rosy cheeks.
Effective: clinical symptoms is clearly better or major part disappears, and energy recovers, and the mental status takes a turn for the better.
Invalid: Clinical symptom and sign is without improvement.
(4) therapeutic effect:
In above-mentioned treatment, treating insomniac 200 example by the present invention, effective 184 examples of result, obvious effective rate is 92%, effective 12 examples, and effective percentage is 6%, invalid 4 examples, and total effective rate is 98%.
These are only the preferred embodiments of the present invention and experimental example, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.All within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (10)

1. a pharmaceutical composition for soothing nerves; it is characterized in that, described pharmaceutical composition includes Cinnabaris, Magnetitum, Os Draconis, Dens Draconis, Concha Ostreae, succinum, Margarita, Semen Ziziphi Spinosae, Semen Platycladi, Radix Polygalae, Caulis Polygoni Multiflori, Herba Albiziae, Semen Tritici aestivi, Sorghum vulgare Pers., Rhizoma et radix valerianae, Linesless charcoal, Ganoderma, Rhizoma Coptidis, Fructus Gardeniae, Calculus Bovis, Plumula Nelumbinis；Described pharmaceutical composition includes following weight parts composition: 5～10 parts of Cinnabaris, Magnetitum 5～10 parts, Os Draconis 1～3 part, Dens Draconis 4～8 parts, Concha Ostreae 1～5 part, succinum 1～3 part, Margarita 1～3 part, Semen Ziziphi Spinosae 4～8 parts, Semen Platycladi 5～10 parts, Radix Polygalae 10～15 parts, Caulis Polygoni Multiflori 4～9 parts, Cortex Albiziae 5～10 parts, Semen Tritici aestivi 4～9 parts, Sorghum vulgare Pers. 1～5 part, Rhizoma et radix valerianae 1～3 part, 40～50 parts of Linesless charcoal, Ganoderma 10～15 parts, Rhizoma Coptidis 3～5 parts, Fructus Gardeniae 1～3 part, Calculus Bovis 5～10 parts.
2. pharmaceutical composition according to claim 1, it is characterised in that described pharmaceutical composition also includes the Plumula Nelumbinis that weight portion is 5～10 parts.
3. pharmaceutical composition according to claim 1; it is characterized in that, described pharmaceutical composition is made up of following weight parts: 8 parts of Cinnabaris, Magnetitum 9 parts, Os Draconis 1 part, Dens Draconis 7 parts, Concha Ostreae 2 parts, succinum 3 parts, Margarita 2 parts, Semen Ziziphi Spinosae 4 parts, Semen Platycladi 10 parts, Radix Polygalae 11 parts, Caulis Polygoni Multiflori 6 parts, Cortex Albiziae 8 parts, Semen Tritici aestivi 9 parts, Sorghum vulgare Pers. 5 parts, Rhizoma et radix valerianae 3 parts, 47 parts of Linesless charcoal, Ganoderma 14 parts, Rhizoma Coptidis 4 parts, Fructus Gardeniae 2 parts, Calculus Bovis 6 parts, Plumula Nelumbinis 7 parts.
4. the pharmaceutical composition for soothing nerves made according to claim 2, its manufacture method is:
The first step, by described Semen Ziziphi Spinosae 4～8 parts, Semen Platycladi 5～10 parts, Radix Polygalae 10～15 parts, Caulis Polygoni Multiflori 4～9 parts, Cortex Albiziae 5～10 parts, Semen Tritici aestivi 4～9 parts, Sorghum vulgare Pers. 1～5 part, Rhizoma et radix valerianae 1～3 part, Ganoderma 10～15 parts, Rhizoma Coptidis 3～5 parts, Fructus Gardeniae 1～3 part, Calculus Bovis 5～10 parts, Plumula Nelumbinis 5～10 parts; co-grinding, powder is standby；
Second step, by powder extracting in water in the first step, filter, extracting solution is standby；
3rd step, by 40～50 parts of Linesless charcoal, 5～10 parts of Cinnabaris, Magnetitum 5～10 parts, Os Draconis 1～3 part, Dens Draconis 4～8 parts, Concha Ostreae 1～5 part, succinum 1～3 part, 1～3 part of mix homogeneously of Margarita, be ground into powder；
4th step, extracting solution heating in second step is condensed into thick paste, and mixes with powder in the 3rd step, after dry, pulverize, be packaged into product.
5. preparation method according to claim 4, it is characterised in that in the first step, the condition of described co-grinding is: the powder after medicinal mixture pulverizing crosses 10 mesh sieves.
6. preparation method according to claim 4, it is characterised in that in second step, the condition of described extraction is: powder in the first step adds the water of gross weight 6～9 times, extracts 2～3 hours under 100 DEG C of conditions.
7. preparation method according to claim 4, it is characterised in that in the third step, the condition of described pulverizing is: the powder after medicinal mixture pulverizing crosses 80 mesh sieves.
8. preparation method according to claim 4, it is characterised in that in the 4th step, the condition of described heating concentration is: when normal pressure 60 DEG C～70 DEG C, concentrated solution is concentrated into the thick paste that relative density is 1.30～1.35.
9. preparation method according to claim 4, it is characterised in that in the 4th step, described dry condition is: dry when normal pressure 60 DEG C～70 DEG C.
10. preparation method according to claim 4, it is characterised in that in the 4th step, the condition of described pulverizing is: the powder after pulverizing crosses 10 mesh sieves.
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