CN103536687B - A kind of health product improving sleep - Google Patents

Abstract

The invention discloses a kind of health product improving sleep, containing Radix Puerariae in the formula of the present invention, with Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi compatibility, it then follows the principle of tcm treatment according to syndrome differentiation, each taste medicine of formula complements each other, and has the effect of the sleep that improves significantly; Except improving the effect of sleep, to the patient with cardiovascular and cerebrovascular diseases such as hypertension, hyperlipidemia, hyperglycemia and migraine, its disease also can be alleviated, for some middle-aged and elderly people, can also contribute to the diseases such as treatment alzheimer disease, dysnoesia, poor memory, metabolism difference.

Description

A kind of health product improving sleep

Technical field

The present invention relates to a kind of health product, specifically a kind of health product improving sleep, belong to field of health care products.

Background technology

Relevant research shows: there is following harm when not having enough sleep: (1) affects the creative thinking of brain: as extended sleep deficiency can affect the creative thinking of brain and processes the ability of things; (2) teen-age growth promoter is affected: the secretion of teen-age growth promoter and growth hormone has certain relation, and the secretion of growth hormone is closely related with sleep, people has a big growth hormone secretion peak after sleeping soundly, there is again several little secretion peak subsequently, and at non-sleep state, growth hormone secretion reduces; (3) cutaneous health: sufficient sleep can make the skin of people obtain good metabolism, do not have enough sleep and the capillary of skin stasis of blood can be caused stagnant, circulation is obstructed, the cell making skin can not get the nutrition of abundance, thus accelerating the aging of skin, skin color is made to seem dark and gloomy and pale, it is easy to black eye blackout and wrinkle occur; (4) cause that disease occurs: often do not have enough sleep or sleep disordered, the proper splitting of cell can be affected, people's mood worry can be made anxious, immunity reduces, thus can cause that all diseases occur, as neurasthenia, flu, gastrointestinal disease etc. possibly even produce the sudden change of cancerous cell and cause the generation of cancer; (5) cause obesity: do not have enough sleep and can cause the decline of human body internal diabetes lipoprotein concentration, the rising of appetite hormone concentration in human body can be caused simultaneously.

There is the different pressures from each side in social life due to people, therefore, sleeping problems have had become as a phenomenon general in " subhealth state " crowd. For more and more general sleeping problems, it has been developed that the health product for improving sleep, or be main component with Chinese medicine, have with Western medicine for main component, and along with the development of the progress of technology and technique, the dosage form of health product also emerges in an endless stream, such as oral liquid, tablet, electuary, decoction pieces etc.

Such as, patent ZL200910040342.5 discloses a kind of tablet improving sleep, and its active component is made up of the raw material of following weight ratio: Cortex Albiziae 15-20, Semen Platycladi 20-25, Radix Polygalae 10-15G, Os Draconis 10-15, Concha Ostreae 15-20, Bulbus Lilii 20-25, Fructus Jujubae 15-20, Caulis Polygoni Multiflori 15-20, Caulis Polygoni Multiflori 15-20, Radix Scrophulariae 5-10, Radix Salviae Miltiorrhizae 10-20, Rhizoma Gastrodiae 5-10, Semen arachidis hypogaeae 10-15, Cinnabaris 1-3;Patent CN1171620C discloses a kind of health food improving sleep, and it is to be prepared from by Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, the Radix Paeoniae Alba, Ganoderma, Radix Ginseng; Patent CN101019980B disclose a kind of have Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Radix Platycodonis, Colla Corii Asini, Radix Polygalae, Semen Platycladi, Radix Glycyrrhizae Preparata, Bulbus Lilii, the Radix Paeoniae Alba to make invigorating the heart and spleen, nourishing blood to tranquillize the mind improvement sleep oral liquid; Disclosed in patent CN100562327C a kind of for health food improving sleep and preparation method thereof, its described health product are respectively through alcohol extraction, reduced vacuum concentration, the dry dry high powder preparing Fructus Schisandrae Chinensis, Herb Gynostemmae Pentaphylli, Radix Et Caulis Acanthopanacis Senticosi, Semen Ziziphi Spinosae extract by walnut oil, Fructus Schisandrae Chinensis, Herb Gynostemmae Pentaphylli, Radix Et Caulis Acanthopanacis Senticosi, Semen Ziziphi Spinosae, then make after mixing homogeneously with walnut oil.

Along with social senilization is increasingly severe, the sleeping problems of middle-aged and elderly people have been also affected by concern. Existing this kind of health product, the rare Chinese medicine material adding class of nourishing in formula having, such as Ganoderma, Radix Panacis Quinquefolii, Radix Ginseng etc., it is expensive, but having little effect, this series products is taken and improper is also resulted in some potential danger, as metabolism crosses slow or too fast, blood pressure lifting suddenly etc.; Have be then have employed tens, the Chinese crude drug of 20 kind, complex, preparation technology is loaded down with trivial details, there is extracts active ingredients not exclusively or the deficiency etc. cut of uncertain therapeutic efficacy.

Summary of the invention

Present invention aim at for the deficiencies in the prior art, it is provided that a kind of health product improving sleep, containing Radix Puerariae in its formula, with Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi compatibility, following the principle of tcm treatment according to syndrome differentiation, each taste medicine of formula complements each other, and has the effect of the sleep that improves significantly; Except improving the effect of sleep, to the patient with cardiovascular and cerebrovascular diseases such as hypertension, hyperlipidemia, hyperglycemia and migraine, its disease also can be alleviated, for some middle-aged and elderly people, can also contribute to the diseases such as treatment alzheimer disease, dysnoesia, poor memory, metabolism difference.

For solving the problems referred to above, the technical solution adopted in the present invention is: a kind of health product improving sleep, is made up of the raw material of following parts by weight or its extract: Arillus Longan 3-50 part, Semen Ziziphi Spinosae 2-50 part, Radix Puerariae 1-10 part, Radix Polygalae 0.5-20 part, Semen Platycladi 0.5-20 part.

The weight proportion of preferred each raw material or its extract is: Arillus Longan 3-32 part, Semen Ziziphi Spinosae 2-35 part, Radix Puerariae 1-8 part, Radix Polygalae 0.5-15 part, Semen Platycladi 0.5-10 part.

Preferred Radix Puerariae extract is Radix Puerariae isoflavone.

Described health food adopts common process to add adjuvant required during the different preparation of preparation, makes soft capsule, hard capsule, granule, tablet or oral liquid.

The preparation method of the health product improving sleep function of the present invention, it is possible to be using water as solvent, Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi carried out jointly the heat extraction of 2-3 time, then filters, it is thus achieved that extracting solution, then mix with Radix Puerariae extract.

Described Radix Puerariae extract is preferably Radix Puerariae isoflavone or the commercially available Radix Puerariae isoflavone that extract by solvents obtains.

The preparation method of the health product improving sleep function of the present invention, it is also possible to using water as solvent, Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi are carried out jointly the heat extraction of 2-3 time, then filter, it is thus achieved that extracting solution, concentration, make efflux of solids extractum, then with fluid extract and Radix Puerariae mixing granulation.

The preparation method of the health product improving sleep function of the present invention, can also be respectively adopted traditional extracting method, as decocting method, reflux extraction, percolation etc. obtain the extract of each taste raw material in formula, then mix according still further to described proportioning, adopt the conventional fabrication process of preparation again, add adjuvant such as emulsifying agent, disintegrating agent, binding agent, regulator etc. and prepare into the health promoting product of pharmaceutically acceptable different dosage form.

The effect acting on or playing of the main component of the present invention is as follows:

(1) Arillus Longan, another name: Fructus Alpiniae Oxyphyllae, ratio order, Fructus Litchi slave, sub-Fructus Litchi, wooden round, black horse pearl, swallow ovum, shark tear, circle eye, honey spleen, unit's eye meat etc., Sapindaceae (Sapindaceae) Euphoria (Dimocarpus), Arillus Longan sweet in the mouth is warm in nature, GUIXIN, spleen channel, suitable in syndrome of deficiency of both heart and spleen and qi-blood deficiency syndrome patient, treatment asthenia is frail, insomnia, forgetful, palpitation with fear, palpitation with a distress feeling, have a guilty conscience dizzy effect significantly, and Arillus Longan contains protein, fat, saccharide, organic acid, crude fibre and multivitamin and mineral etc. Arillus Longan can anti-lipid peroxidation and improve activities of antioxidant enzymes, point out it to have certain anti-aging effects; The effects such as Arillus Longan has raising body's immunity, it is suppressed that tumor cell, blood fat reducing, increases coronary artery blood flow, enhancing body quality;

(2) Semen Ziziphi Spinosae, calls Semen Ziziphi Spinosae, Fructus Choerospondiatis, Semen Ziziphi Spinosae, nature and flavor: sweet, puts down; Gui Jing: heart channel; Spleen channel; Liver Channel; Gallbladder meridian, function: mind tranquilizing and the heart calming; Nourishing the liver; Arresting sweating, cures mainly: restlessness of asrhenia type and insomnia; Palpitation with fear palpitation with a distress feeling; Body void spontaneous perspiration, night sweat. Semen Ziziphi Spinosae nourishing the liver, mind calming, calm the nerves, arresting sweating. Effect: have calmness, hypnosis, analgesia, anticonvulsant action; There is certain hypotensive effect; Uterus there is excitation; For deficiency of YIN-blood, severe palpitation, insomnia forgetfulness; Body void hyperhidrosis;

(3) Radix Puerariae, nature and flavor are sweet pungent, flat, Gui Jing: enter spleen, stomach warp; Tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling, function cures mainly: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, and relieving restlessness is temperature only, and cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf; Modern medicine study shows: hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease are had certain curative effect by the isoflavonoid puerarin in Radix Puerariae;

(4) Radix Polygalae, another name: Polygala amara, spine aster, spine garden, Caulis et Folium Polygalae Tenuifoliae root bark, Herba Ceratophylli Demeersi root bark etc., warm in nature, bitter in the mouth, pungent, tepor, GUIXIN, kidney, lung meridian, the function there is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, epilepsy mania and irritation, spasm is twitched, skin sore, breast swell and pain;

(5) Semen Platycladi, another name: Semen Platycladi, Bai Ren, cedar seed, Bai Shi, Cacumen Platycladi core, Bai Mai, Semen Platycladi cream, Cedar, property is sweet, and taste is put down, and GUIXIN, kidney, large intestine channel cure mainly tranquilizing by nourishing the heart, loosening bowel to relieve constipation. For diseases such as restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine constipation.

The present invention provides the benefit that relative to prior art:

(1) inventive formulation is simple, compatibility is reasonable, follow the principle of tcm treatment according to syndrome differentiation, the each taste medicine of formula complements each other, and proves through animal experiment, has the effect of the sleep that improves significantly, human non-toxic is harmless, being improved the health-care effect of immunity, the safety of product is high, and the customary preparation methods of the available preparation medically approved prepares into the health product improving sleep of different dosage form;

(2) owing to formula have employed Radix Puerariae or its extract, wherein contain more than 20 kind of isoflavones components, Radix Puerariae glycoside, triterpenes, alkaloid and other active component, hence in so that these health product are also applied for having hypertension, hyperlipidemia, the patient of the cardiovascular and cerebrovascular disease such as hyperglycemia and migraine, after taking certain course for the treatment of, above-mentioned patient sleeps is effect improved all right, its disease also can be mitigated, for some middle-aged and elderly people, except its sleep disorder can be improved, can also contribute to treatment alzheimer disease, dysnoesia, poor memory, the diseases such as metabolism difference.

Detailed description of the invention

By the examples below the present invention being described in further details, these embodiments are only used for the present invention is described, do not limit the scope of the invention.

Embodiment 1 is adopted the following step to prepare the health product (oral liquid) of the present invention by following raw material:

(1) raw material is prepared as follows: Arillus Longan 300g, Semen Ziziphi Spinosae 200g, Radix Puerariae 100g, Radix Polygalae 50g, Semen Platycladi 50g;

(2) prepared by extracting solution: the weight proportion of preferred each raw material or its extract is: Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi are collectively disposed in extraction pot, adds the water of raw medicinal material weight 5 times, after soaking 1 hour, heating, to 100 DEG C, keeps decocting 1 hour at this temperature, filters, obtain and extract filtrate for the first time, again in extraction pot, add the water of raw medicinal material weight 5 times, soak 1 hour, heating is to 95 DEG C, keep decocting 2 hours at this temperature, filter, it is thus achieved that second time extracts filtrate; Mixing with Radix Puerariae extract, Radix Puerariae isoflavone adopts extract by solvents to obtain again;

(3) the extracting solution mixture obtained is mixed homogeneously with Radix Puerariae isoflavone, prop up fill according to 10ml/, then through high-temp sterilizing, can be prepared by oral liquid.

Embodiment 2 is adopted the following step to prepare the health product (granule) of the present invention by following raw material:

(1) raw material is prepared as follows: Arillus Longan 80g, Semen Ziziphi Spinosae 40g, Radix Puerariae 60g, Radix Polygalae 100g, Semen Platycladi 100g;

(2) prepared by extracting solution: Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi are collectively disposed in extraction pot, adds the water of raw medicinal material weight 4 times, soaks 2 hours, heating, to 100 DEG C, keeps decocting 1 hour at this temperature, filters, obtain and extract filtrate for the first time, again in extraction pot, add the water of raw medicinal material weight 5 times, soak 1 hour, heating is to 100 DEG C, keep decocting 2 hours at this temperature, filter, obtain second time and extract filtrate;

(3) twice extracting solution is merged, be under 70 DEG C of conditions in temperature, vacuum 0.06Mpa, being concentrated into that solid-liquid ratio focuses on when measuring under 55 DEG C of conditions is 1.15 acquisition fluid extracts;

(4) Radix Puerariae is clean, dried, carry out coarse pulverization, cross 16 mesh sieves, obtain coarse powder;

(5) fluid extract and Radix Puerariae coarse powder adopt common process carry out granulating, dry, granulate, mix, subpackage, to obtain final product.

Embodiment 3 is adopted the following step to prepare the health product (capsule) of the present invention by following raw material:

(1) raw material is prepared as follows: Arillus Longan 100g, Semen Ziziphi Spinosae 100g, Radix Puerariae 20g, Radix Polygalae 40g, Semen Platycladi 40g;

(2) prepared by extracting solution: Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi are collectively disposed in extraction pot, adds the water of raw medicinal material weight 4 times, soaks 1 hour, heating, to 100 DEG C, keeps decocting 1 hour at this temperature, filters, obtain and extract filtrate for the first time, again in extraction pot, add the water of raw medicinal material weight 4 times, soak 1 hour, heating is to 100 DEG C, keep decocting 2 hours at this temperature, filter, obtain second time and extract filtrate; Adding the water of raw medicinal material weight 4 times, soak 0.5 hour, heating, to 100 DEG C, keeps decocting 1 hour at this temperature, filters, it is thus achieved that third time extracts filtrate;

(3) three extracting solution are merged, be under 80 DEG C of conditions in temperature, vacuum 0.05Mpa, being concentrated into that solid-liquid ratio focuses on when measuring under 50 DEG C of conditions is 1.2 acquisition fluid extracts;

(4) Radix Puerariae is clean, dried, carry out coarse pulverization, cross 14 mesh sieves, obtain coarse powder;

(5) adopt common process to carry out mixing granulation, add Pulvis Talci, magnesium stearate fluid extract and Radix Puerariae coarse powder, fill and make hard capsule preparation.

Claims (2)

1. the health product improving sleep, it is characterised in that: adopted health-care product particle agent prepared by the following step by following raw material:

(1) raw material is prepared as follows: Arillus Longan 80g, Semen Ziziphi Spinosae 40g, Radix Puerariae 60g, Radix Polygalae 100g, Semen Platycladi 100g;

(2) prepared by extracting solution: Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi are collectively disposed in extraction pot, adds the water of raw medicinal material weight 4 times, soaks 2 hours, heating, to 100 DEG C, keeps decocting 1 hour at this temperature, filters, obtain and extract filtrate for the first time, again in extraction pot, add the water of raw medicinal material weight 5 times, soak 1 hour, heating is to 100 DEG C, keep decocting 2 hours at this temperature, filter, obtain second time and extract filtrate;

(3) twice extracting solution is merged, be under 70 DEG C of conditions in temperature, vacuum 0.06Mpa, being concentrated into that solid-liquid ratio focuses on when measuring under 55 DEG C of conditions is 1.15 acquisition fluid extracts;

(4) Radix Puerariae is clean, dried, carry out coarse pulverization, cross 16 mesh sieves, obtain coarse powder;

(5) fluid extract and Radix Puerariae coarse powder adopt common process carry out granulating, dry, granulate, mix, subpackage, to obtain final product.

2. the health product improving sleep, it is characterised in that: adopted health product capsule prepared by the following step by following raw material:

(1) raw material is prepared as follows: Arillus Longan 100g, Semen Ziziphi Spinosae 100g, Radix Puerariae 20g, Radix Polygalae 40g, Semen Platycladi 40g;

(2) prepared by extracting solution: Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi are collectively disposed in extraction pot, adds the water of raw medicinal material weight 4 times, soaks 1 hour, heating, to 100 DEG C, keeps decocting 1 hour at this temperature, filters, obtain and extract filtrate for the first time, again in extraction pot, add the water of raw medicinal material weight 4 times, soak 1 hour, heating is to 100 DEG C, keep decocting 2 hours at this temperature, filter, obtain second time and extract filtrate; Adding the water of raw medicinal material weight 4 times, soak 0.5 hour, heating, to 100 DEG C, keeps decocting 1 hour at this temperature, filters, it is thus achieved that third time extracts filtrate;

(3) three extracting solution are merged, be under 80 DEG C of conditions in temperature, vacuum 0.05Mpa, being concentrated into that solid-liquid ratio focuses on when measuring under 50 DEG C of conditions is 1.2 acquisition fluid extracts;

(4) Radix Puerariae is clean, dried, carry out coarse pulverization, cross 14 mesh sieves, obtain coarse powder;

(5) adopt common process to carry out mixing granulation, add Pulvis Talci, magnesium stearate fluid extract and Radix Puerariae coarse powder, fill and make hard capsule preparation.