CN105457005A - Traditional Chinese medicine composition used for treating bronchial asthma and preparation method thereof - Google Patents

Traditional Chinese medicine composition used for treating bronchial asthma and preparation method thereof Download PDF

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CN105457005A
CN105457005A CN201610001294.9A CN201610001294A CN105457005A CN 105457005 A CN105457005 A CN 105457005A CN 201610001294 A CN201610001294 A CN 201610001294A CN 105457005 A CN105457005 A CN 105457005A
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chinese medicine
medicine composition
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treatment
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王林
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Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
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Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract

The invention discloses a traditional Chinese medicine composition used for treating bronchial asthma and a preparation method thereof. The traditional Chinese medicine composition is prepared from ginger, radix angelicae, flower buds of lily magnolia, small centipeda herb, pericarpium citri reticulatae, agilawood, sandalwood, fingered citron, fructus citri, flowers of Prunus mume Sieb. et Zucc., radish seeds, inula flowers, rhizoma cynanchi stauntonii, radix ranunculi ternati, sweet almonds, fructus perillae, radix asteris, common coltsfoot flowers, ginkgoes, thorny elaeagnus leaves, magnetite, cortex albiziae, polygala roots, lucid ganoderma, officinal magnolia bark, hericium erinaceus, rhizoma cynanchi stauntonii, Japanese metaplexis pericarp, linum perenne L. and black nightshade herb. The traditional Chinese medicine composition has the advantages that based on the theory of traditional Chinese medicine, with the main objectives of warming the lung for dispelling cold and resolving sputum for relieving asthma, the traditional Chinese medicine composition is mainly used for treating bronchial asthma, particularly, cold asthma and is capable of taking effect fast, definite in treatment effect, high in safety and free of toxic or side effects, and relapse is not likely to occur.

Description

Chinese medicine composition being used for the treatment of bronchial asthma and preparation method thereof
This case is divisional application, and the denomination of invention of original application is: medicine being used for the treatment of bronchial asthma and preparation method thereof, and the applying date of original application is: 2014-04-23, and the application number of original application is: 201410163338.9.
Technical field
The present invention relates to pharmaceutical technology, particularly relate to a kind of Chinese medicine composition being used for the treatment of bronchial asthma and preparation method thereof.
Background technology
Bronchial asthma (bronchialasthma) is by the various kinds of cell particularly chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte, in susceptible person, this kind of inflammation can cause panting of recurrent exerbation, the symptoms such as tachypnea, uncomfortable in chest and cough, how occurring at night and morning, air flue increases multiple stimulating factor reactivity.
Clinical manifestation: typical bronchial asthma, has premonitory symptom as sneeze, watery nasal discharge before outbreak, cough, uncomfortable in chest etc., as processed not in time, asthma can be there is because bronchial obstruction increases the weight of, severe patient can be forced to take seat or in orthopnea,, even there is cyanosis etc. in dry cough or cough up a large amount of white foam expectorant, but generally can voluntarily or with alleviating voluntarily or with after the treatments such as suppressing panting calming medicine, some patient can again show effect after alleviation a few hours, even causes status asthmaticus.In addition, also there is the asthma of atypical presentation clinically, as cough variant asthma, patient is coughing more than 2 months without obvious inducement, night and morning often show effect, motion, cold airs etc. bring out and increase the weight of, and measurement of bronchial responsiveness has high response, antibiotic or antitussive, expectorant is failed to respond to any medical treatment, and uses bronchial spasmolytic agent or 17-hydroxy-11-dehydrocorticosterone effectively, but need get rid of the other diseases causing cough.
According to the difference with or without anaphylactogen and age of onset, be divided into extrinsic asthma and intrinsic asthma clinically, extrinsic asthma is everlasting childhood, falls ill during teenager, Duo You family allergies, for anaphylaxis, intrinsic asthma is then many without known anaphylactogen, adult onset, without obviously seasonal, rare allergies, may be caused by In vivo infection stove.No matter which kind of asthma, mild can spontaneous remission gradually, and the catabasis is without any symptom or abnormal sign.
At present, treat bronchial asthma many uses agents to treat: (one) adrenomimetic drug medicine is as ephedrine, epinephrine and isoproterenol etc.; (2) theophylline (xanthine) class medicine is as aminophylline; (3) anticholinergic agent: common drug has atropine, scopolamine, 654-2 and ipratropium bromide (ipratropiumbromide) etc.; (4) calcium antagonist: diltiazem grass, verapamil, nifedipine is oral or suck; (5) Adrenal Glucocorticoid.But the side effect of western medical treatment bronchial asthma is more, easily produces untoward reaction, such as, the local side effects of inhaled is: the monilial infection of pars oralis pharyngis, dysphonia and the upper respiratory tract irritable cough occurred once in a while, being used alone bronchodilatation medicine carries out treating comprehensive not, for in, severe asthma, only by using bronchodilators (as β2agonists) even harmful regularly, because β2agonists is without antiinflammatory action, simple symptomatic treatment can cover inflammatory development, airway hyperreactivity is increased the weight of, thus necessary use in conjunction anti-inflammatory drug, if but the more different types of medicine of prolonged application inherently increases the weight of liver while generation drug resistance, the burdens such as the toxin expelling of the internal organs such as kidney, affect organ function, immunity of organisms is caused to decline, even increase the weight of the state of an illness etc.
The traditional Chinese medical science thinks that bronchial asthma belongs to motherland's medical science bronchial wheezing category.Bronchial wheezing is due to retained phlegm volt lung, meets inducement or feels heresy and draw tactile, so that stagnation of phlegm air flue, impairment of purifying and descending function of the lung, the ictal rale asthma illness caused by mental disorder fight.Whistling sound in the throat during outbreak, tachypnea and dyspnea, even failing to lie flat due to dyspnea is main manifestations.
Summary of the invention
Technical problem solved by the invention is, a kind of Chinese medicine composition being used for the treatment of bronchial asthma and preparation method thereof is provided, this Chinese medicine composition is based on warming lung for dispelling cold, resolving phlegm and relieving asthma, and primary treatment bronchial asthma especially cold asthma has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition being used for the treatment of bronchial asthma, wherein, following raw medicinal material is comprised: Rhizoma Zingiberis Recens, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Pericarpium Citri Reticulatae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Citri Sarcodactylis, Fructus Citri, FLOS MUME, Semen Raphani, Flos Inulae, Rhizoma Cynanchi Stauntonii, Radix Ranunculi Ternati, Semen pruni armeniacae, Fructus Perillae, Radix Asteris, Flos Farfarae, Semen Ginkgo, Folium Elaeagni, Magnetitum, Cortex Albiziae and Radix Polygalae.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Rhizoma Zingiberis Recens 10-15 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Flos Magnoliae 10-15 weight portion, Herba Centipedae 15-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Lignum Aquilariae Resinatum 10-15 weight portion, Lignum Santali Albi 10-15 weight portion, Fructus Citri Sarcodactylis 15-20 weight portion, Fructus Citri 10-15 weight portion, FLOS MUME 10-18 weight portion, Semen Raphani 10-15 weight portion, Flos Inulae 10-15 weight portion, Rhizoma Cynanchi Stauntonii 10-20 weight portion, Radix Ranunculi Ternati 10-15 weight portion, Semen pruni armeniacae 15-20 weight portion, Fructus Perillae 10-15 weight portion, Radix Asteris 10-15 weight portion, Flos Farfarae 10-20 weight portion, Semen Ginkgo 3-5 weight portion, Folium Elaeagni 10-15 weight portion, Magnetitum 3-5 weight portion, Cortex Albiziae 10-15 weight portion and Radix Polygalae 10-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Rhizoma Zingiberis Recens 13 weight portion, the Radix Angelicae Dahuricae 15 weight portion, Flos Magnoliae 13 weight portion, Herba Centipedae 17 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Lignum Aquilariae Resinatum 12 weight portion, Lignum Santali Albi 12 weight portion, Fructus Citri Sarcodactylis 18 weight portion, Fructus Citri 12 weight portion, FLOS MUME 14 weight portion, Semen Raphani 12 weight portion, Flos Inulae 12 weight portion, Rhizoma Cynanchi Stauntonii 15 weight portion, Radix Ranunculi Ternati 12 weight portion, Semen pruni armeniacae 18 weight portion, Fructus Perillae 12 weight portion, Radix Asteris 12 weight portion, Flos Farfarae 15 weight portion, Semen Ginkgo 4 weight portion, Folium Elaeagni 13 weight portion, Magnetitum 4 weight portion, Cortex Albiziae 12 weight portion and Radix Polygalae 15 weight portion.
Described Chinese medicine composition also comprises following raw medicinal material: Ganoderma, Cortex Magnoliae Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Rhizoma Cynanchi Stauntonii, Pericarpium Metaplexis, Iinum peerenne L. and Herba Solani Nigri.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Rhizoma Zingiberis Recens 10-15 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Flos Magnoliae 10-15 weight portion, Herba Centipedae 15-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Lignum Aquilariae Resinatum 10-15 weight portion, Lignum Santali Albi 10-15 weight portion, Fructus Citri Sarcodactylis 15-20 weight portion, Fructus Citri 10-15 weight portion, FLOS MUME 10-18 weight portion, Semen Raphani 10-15 weight portion, Flos Inulae 10-15 weight portion, Rhizoma Cynanchi Stauntonii 10-20 weight portion, Radix Ranunculi Ternati 10-15 weight portion, Semen pruni armeniacae 15-20 weight portion, Fructus Perillae 10-15 weight portion, Radix Asteris 10-15 weight portion, Flos Farfarae 10-20 weight portion, Semen Ginkgo 3-5 weight portion, Folium Elaeagni 10-15 weight portion, Magnetitum 3-5 weight portion, Cortex Albiziae 10-15 weight portion, Radix Polygalae 10-18 weight portion, Ganoderma 10-20 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Hericium erinaceus (Bull. Ex Fr.) Pers. 15-20 weight portion, Rhizoma Cynanchi Stauntonii 15-20 weight portion, Pericarpium Metaplexis 15-20 weight portion, Iinum peerenne L. 10-15 weight portion and Herba Solani Nigri 15-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Rhizoma Zingiberis Recens 13 weight portion, the Radix Angelicae Dahuricae 15 weight portion, Flos Magnoliae 13 weight portion, Herba Centipedae 17 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Lignum Aquilariae Resinatum 12 weight portion, Lignum Santali Albi 12 weight portion, Fructus Citri Sarcodactylis 18 weight portion, Fructus Citri 12 weight portion, FLOS MUME 14 weight portion, Semen Raphani 12 weight portion, Flos Inulae 12 weight portion, Rhizoma Cynanchi Stauntonii 15 weight portion, Radix Ranunculi Ternati 12 weight portion, Semen pruni armeniacae 18 weight portion, Fructus Perillae 12 weight portion, Radix Asteris 12 weight portion, Flos Farfarae 15 weight portion, Semen Ginkgo 4 weight portion, Folium Elaeagni 13 weight portion, Magnetitum 4 weight portion, Cortex Albiziae 12 weight portion, Radix Polygalae 15 weight portion, Ganoderma 15 weight portion, Cortex Magnoliae Officinalis 17 weight portion, Hericium erinaceus (Bull. Ex Fr.) Pers. 17 weight portion, Rhizoma Cynanchi Stauntonii 18 weight portion, Pericarpium Metaplexis 18 weight portion, Iinum peerenne L. 12 weight portion and Herba Solani Nigri 17 weight portion.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the Chinese medicine composition of bronchial asthma, the dosage form of described Chinese medicine composition is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
The dosage form of described Chinese medicine composition is oral liquid, and its preparation method comprises the following steps:
The first step, by Pericarpium Citri Reticulatae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Citri Sarcodactylis, Fructus Citri, FLOS MUME and Semen Raphani mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 4 times, each 3 ~ 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.36 ~ 1.38, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 8 times of water gagings, boils 3 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.34;
3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 60 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
The invention has the beneficial effects as follows: Chinese medicine Chinese medicine composition of the present invention, utilize the theory of Chinese medical science that China is traditional, based on warming lung for dispelling cold, resolving phlegm and relieving asthma, primary treatment bronchial asthma especially cold asthma has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition being used for the treatment of bronchial asthma, wherein, following raw medicinal material is comprised: Rhizoma Zingiberis Recens, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Pericarpium Citri Reticulatae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Citri Sarcodactylis, Fructus Citri, FLOS MUME, Semen Raphani, Flos Inulae, Rhizoma Cynanchi Stauntonii, Radix Ranunculi Ternati, Semen pruni armeniacae, Fructus Perillae, Radix Asteris, Flos Farfarae, Semen Ginkgo, Folium Elaeagni, Magnetitum, Cortex Albiziae and Radix Polygalae; Preferably, Chinese medicine composition also comprises following raw medicinal material: Ganoderma, Cortex Magnoliae Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Rhizoma Cynanchi Stauntonii, Pericarpium Metaplexis, Iinum peerenne L. and Herba Solani Nigri.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Rhizoma Zingiberis Recens: Rhizoma Zingiberis Recens refers to the tuber stem of ginger, calls purple Rhizoma Zingiberis Recens, Rhizoma Zingiberis Recens, fresh ginger, old ginger.Warm in nature, its distinctive " gingerol " energy stimulating gastrointestinal mucosa, make gastrointestinal redness, digestion power strengthens, and effectively can treat the abdominal distention, stomachache, diarrhoea, vomiting etc. of eating cold and cool food and too much causing.After eating Rhizoma Zingiberis Recens, people has the sensation of body heat, this is because it can distend the blood vessels, blood circulation is accelerated, and impels pore with it to open, so not only the unnecessary torrid zone can be walked, also the pathogenic bacteria in body, cold are together taken out of simultaneously.When health has eaten cold and cool thing, be subject to drench with rain or stay in air-conditioned room long afterwards, eaten Rhizoma Zingiberis Recens and just can eliminate in time because human body is trembled with fear the various discomforts remake.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel." Japan hanako materia medica ": " control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, scabies, desolation, pain relieving granulation promoting, go face Shao-defect scar." Compendium of Material Medica: " control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, married woman's blood dizziness due to wind pathogen is transported, bleeding urine, and regurgitation of food from the stomach tells food; Solution arsenic poison, snakebite, cutter arrow incised wound." function expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifying are sensible, detumescence and apocenosis.Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet Sheng chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, venom.Can improve microcirculation in human body, promote skin metabolism, and the water soluble ingredient of the Radix Angelicae Dahuricae has vasoconstrictor effects, the Coumarins composition byak-angelicin of the Radix Angelicae Dahuricae has dilating effect to coronary vasodilator.
Flos Magnoliae: pungent, warm, nontoxic.Attach to the lung and stomach meridians.Dispersing wind and cold, clearing the nasal passage." detailed outline ": " nasal abscess after nasal sinusitis, allergic rhinitis, stuffy nose, nasal abscess and pox, and with grinding into powder, enter Moschus a little, Bulbus Allii Fistulosi is dipped into for several times." " Mingyi Bielu ": " stuffy nose relieving plug, tears go out for warming middle-JIAO expelling pathogenic factors from muscles, sharp nine orifices, control swelling of the face and draw toothache, and dizziness, body are several as person on car and boat." for headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.
Herba Centipedae: dispersing wind-cold, clearing the nasal passage, cough-relieving, removing toxic substances.Compendium of Material Medica: " loose conjunctival congestion is swollen for removing toxic substances, improving eyesight, nebula, and deaf, headache olic acid, controls Tan Nve Snore clam, have a stuffy nose obstructed, and plug breath is from falling, and loose skin ulcer swells again." this savors decoct 25-50% has inhibitory action to tubercule bacillus.This product volatile oil and ethanol extract part have cough-relieving, eliminate the phlegm, antiasthmatic effect.Brevelin display has inhibitory action to rat Walker sarcoma, and the derivant of some Helenalin also shows active anticancer.The hot water extract of Herba Centipedae provides significant antiallergic activity through passive cutaneous anaphylaxis test performance.Arnicolidec, 6-O-Senecioylplenolin, Aurantiamideacetate and three flavone compound Quercetins-3 of obtaining is separated by the methanol soluble part of the chloroform extract of Herba Centipedae, 3 dimethyl esters, Quercetin 3-methyl ester and apigenin all show stronger antiallergic activity.
Pericarpium Citri Reticulatae: nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Therefore Pericarpium Citri Reticulatae has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three large on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can support spleen, pungently can be amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and the gas of middle Jiao passes through, and the gas of three Jiao is also sprung up thereupon.Three Jiao are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, upper and the heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, wet throughout whole body.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold, can control abundant expectoration cough with asthma, and gas is stopped up food and stopped; Say from the heart, then pungent happy gas, hardship lets out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; Say from liver, then pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver be strongly fragrant heat, drink is stopped eating stagnant; Say from kidney, then pungent profit kidney is dry, and hardship is let out kidney and wet, gentle kidney qi, so it can control life fire deficiency, and indigestion.Certainly, all explanations are all relevant with spleen with wet, so its property of medicine effect performance leeway is larger, all can use in general activating QI to eliminate phlegm side.Have hypotensive effect slowly to anesthetized rabbit, cat, dog intravenous injection, its decompression principle is owing to directly acting on vascular smooth muscle.
Lignum Aquilariae Resinatum: pungent, bitter, temperature; Return spleen, stomach, kidney, lung meridian." Japan hanako materia medica ": " in tune, tonifying five ZANG-organs, nourishing essence and tonifying YANG, warm waist knee joint, uncharm gas.Ending tendon transfer, vomiting and diarrhoea, cold air, broken disease addiction, (controlling) cold wind is benumbed, and joint is not appointed, and wet wind skin is itched, cardiac and abdominal pain, diarrhea due to disorder of qi." Compendium of Material Medica: " control heat in the upper and cold in the lower, QI rising in reverse order is panted, and asthenia of the large intestine closes, urine qi stranguria, man's cold sperm." " book on Chinese herbal medicine is newly organized ": " feeble QI temperature, sun is also, nontoxic for Lignum Aquilariae Resinatum, acrid in the mouth.Enter the gate of vitality.Mend fire mutually, press down cloudy supporing yang, support all gas, exceedingly high ability, control vomiting and diarrhoea, draw Zang Shengong under kidney fire, the gas of peace vomiting, on lead in heart, be the quality goods of heart kidney handing-over.Again temperature and not hot, can commonly use with Yiyang person also." function sending down the abnormal ascending QI warming middle-JIAO, warming the kidney is supporing yang.Control QI rising in reverse order to pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.Decocting wine sinks liquid and obviously to slow down the mice intestine movement that neostigmine causes, and presents smooth muscle spasmolysis effect.Lignum Aquilariae Resinatum benzene extraction component obviously can extend the length of one's sleep of mice hexobarbital to mouse stomach.
Lignum Santali Albi: pungent, temperature; Return spleen, stomach, the heart, lung meridian; Row heart warming middle-JIAO, appetizing pain relieving.External application can antiinflammatory be gone to swell, Glycerin; Smouldering can sterilizing, drives pestilence and wards off epidemic disease.The Oleum Santali albi extracted from sandalwood is pharmaceutically also having been widely used, there is the multi-efficiencies such as refrigerant, convergence, heart tonifying, nourishing, greasy skin, can be used to treatment bile sick, the disease such as cystitis, gonorrhea and stomachache, heating, vomiting, effective especially to be full of cracks, rich and honour hands, black speck, the mosquito disease such as to bite, be exactly to controlling dermopathic important medicine since time immemorial.Strengthen gastrointestinal peristalsis, the secretion of facilitating digestion liquid.Lignum Santali Albi liquid, to isolated frog heart perfusion, in negative inotropic action, has antagonism to decoction for Resuscitation, the poisoning caused arrhythmia of Cortex Acanthopancis; Oleum Santali albi has diuresis; Inhibitory action is had to dysentery bacterium, tubercule bacillus.
Fructus Citri Sarcodactylis: pungent, bitter, sour, temperature; Return liver, spleen, lung meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " Fructus Citri Sarcodactylis disappears cold syndrome of the stomach expectorant, controls gastric qi pain, the only cold pain in face, and middle circulation of qi promoting for tonifying liver warming the stomach, anti-nausea." " book on Chinese herbal medicine is new again ": " control gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass controls dysphagia and regurgitation, eliminating mass abdominal mass scrofula." liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.Limettin contained by this product shrinks guinea-pig isolated trachea caused by histamine, has antagonism; Show there is certain antiallergic activity in the isolated ileum segments in guinea pigs of Ovum Gallus domesticus album sensitization and isolated tracheal test.This product ethanol extract has obvious inhibitory action to rat, rabbits infestines, and intravenous administration also has same inhibitory action to anesthetized cat, rabbit at body intestinal tube.Fructus Citri Sarcodactylis ethanol extract significantly can increase the coronary flow of guinea pig isolated heart and improve the hypoxia-bearing capability of mice; Protective effect is had to the myocardial ischemia that rat causes because of pituitrin.
Fructus Citri: acrid in the mouth, sweet, nontoxic." explaining abstruseness of the canon of materia medica ": " gas of the reason part of the body cavity above the diaphragm housing the heart and lungs, preventing or arresting vomiting is inverse, feed, spleen invigorating." " book on Chinese herbal medicine is new again ": " suppressing the hyperactive liver Shu Yu, reason lung qi, stimulate the menstrual flow diuretic, controls waist beriberi." function depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, dehumidifying and in.Cure mainly the therapeutic method to keep the adverse QI flowing downwards, except mind expectorant water.Boil wine to drink, control mental disorder cough.Decoct water, control pain due to disorder of QI under the heart.Root leaf is skin-deep same.These product are pungent can manage it loose, and the catharsis of bitter energy, enters Liver Channel and can unclog and readjust irritability and pain relieving.The strongly fragrant distending pain in the chest and hypochondrium for the treatment of the liver, gas perfume (or spice) is amusing, and pungent row hardship is let out, and enters taste with promoting the circulation of QI to alleviate the stagnation in middle-JIAO.With the abdominal distention controlling stagnation of QI in spleen and stomach, bitter dry the falling of these product is let out with preventing phlegm from forming and stopping coughing, and pungent row enters lung and the chest stuffiness relieving of regulating the flow of vital energy.With controlling abundant expectoration, cough, uncomfortable in chest etc.Hesperidin contained by these product to Cavia porcellus for want of vitamin C and cause eyes bulbar conjunctiva intravascular cells cohesion and capillary resistance reduce be improved effect, the cohesion of horse blood cell can be reduced.Hesperidin has prevention cold injury and suppresses the aldehyde reductase effect of rat lens.Obacunone has the effect strengthening isolated rabbit intestinal tension force and amplitude.
FLOS MUME: sour and astringent, flat.Return liver, stomach, lung meridian.Supplementary Amplifications of the Compendium of Materia Medica: " " all sorts of flowers mirror ": powder for improving appetite is evil, and food of cooking congee, help the gas of sun clearly to rise, distillation point tea, promoting the production of body fluid to quench thirst, expelling summer-heat is washed tired." soothing liver-QI, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizzy, scrofula.Stomachache due to hyperactive liver-QI attacking the stomach.The circulation of qi promoting of this product fragrance enters liver stomach, and energy dispersing the stagnated live-QI to relieve the stagnation of QI, is amusing, regulating the flow of Qi and the middle Jiao.
Semen Raphani: property is put down, acrid in the mouth, sweet; Return lung, spleen, stomach warp.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, belch, heavy after dysentery, cough with copious phlegm, dyspnea with rapid and short breath fullness in the chest.Breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots.Enter spleen, stomach, lung meridian, can help digestion de-swelling, and effect is remarkable, has the title of " rush wall fall wall ".Clinical habit is used for the treatment of real (eat, wet, stagnate) card.But these product are not only the de-swellings that helps digestion, and to deficiency syndrome with it, obtain effect also good, because of its property peace, its abnormal smells from the patient is not high again, and what without the fraud of victory partially, can not be limited to " rush wall fall wall " says there is the suspicion of dispelling the stagnated QI (being having a surplus of flat gas actually), and gives it up.Semen Raphani water extract has significant inhibitory action to staphylococcus and escherichia coli etc., and water extract has obvious hypotensive effect, for anesthetized rabbit, cat and dog, animal blood pressure all can be caused during intravenous injection to decline.
Flos Inulae: salty, warm; Enter lung, liver, stomach warp.Function expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water." herbal classic ": " main stagnation of QI, fullness in the hypochondrium, palpitation with fear.Dewater, remove cold and heat between the five internal organs, invigorating middle warmer, the therapeutic method to keep the adverse QI flowing downwards." " property of medicine opinion ": " main rib side of body gas, lower cold and heat edema, cures mainly bladder retained water, goes by large abdomen, appetizing, the inverse not lower food of preventing or arresting vomiting." cure mainly expectorant knot in the heart, the lower distension of the side of body, cough with asthma, singultus, saliva as shellac varnish, epigastric oppression Ying, eructation unrelieved, extensive abdominal edema.
Rhizoma Cynanchi Stauntonii: pungent, bitter, tepor; Return lung meridian.Tang Materia Medica: " Rhizoma Cynanchi Stauntonii, Ye Siliu, or like Flos Genkwa, height of seedling chi is permitted, on the desert of a raw small piece of land surrounded by water, continent.Root is white, is longer than Herba Asari, sweet in the mouth.Custom takes with wine stain, Zhu Shangqi.Not raw shortcut.The present uses climing survivor, bitter in the mouth, and non-real also." " herbal classic is met former ": " Rhizoma Cynanchi Stauntonii, comparatively Radix Cynanchi Atrati is slightly warm, and comparatively Herba Asari is slightly flat.Specially search edema due to wind pathogen in lung key, if non-Radix Cynanchi Atrati is salty-cold, specially let out lung, stomach scorching, also do not alter like the pungent of Herba Asari, can control kidney, liver heavy cold also." lowering the adverse-rising QI to resolve phlegm, cough-relieving.Cough with copious phlegm, asthma.This product slightly warm in nature and not dry strong, is longer than and eliminates the phlegm, fall lung qi with flat cough with asthma.No matter genus is cold belongs to heat, Exogenous and internal injuries, chronic cough of newly coughing all available it.Cough with asthma belongs to the deficiency of vital energy and does not return first person, should not apply.Fry Rhizoma Cynanchi Stauntonii slow fire to heat, fry to strong yellow, micro-Jiao, taking-up cools.Stir-fry retrodeviates in warming lung for dispelling cold, preventing phlegm from forming and stopping coughing, is used for cold-phlegm or phlegm-damp, cough with asthma.
Radix Ranunculi Ternati: sweet, pungent, tepor.Return liver, lung meridian.Dissipating phlegm and resolving masses, removing toxic substances and promoting subsidence of swelling.Cure mainly scrofula sucutaneous nodule, furuncle, worm venom, migraine, malaria, toothache.Pulmonary tuberculosis, tuberculous lymphadenitis, lymphadenitis, pharyngolaryngitis.For the mechanism of Radix Ranunculi Ternati anti-tubercle bacillus, Zhan Li etc. adopt reverse transcriptional PCR sxemiquantitative (QC-RT-PCR) method and PCR method, Radix Ranunculi Ternati effective ingredient Seynuns Kugelann lactone (Tern) have been carried out to the research of anti-tubercle bacillus molecular immunology mechanism.Result shows that Tern may inducing peripheral blood vessel GLS high level gene expression, kills pathogenic bacterium MBT in born of the same parents, and in dose dependent, to drug resistance with untreated lunger's induced levels no significant difference.Zhang Jiahua etc. adopt cell counting and 3H-Tdr incorporation methods anyway, and compare with homoharringtonine, and indicating eryside all has certain lethal effect to various leukaemia.
Semen pruni armeniacae: property is put down, and sweet in the mouth, enters lung, large intestine two warp." modern Practical Chinese medicinal ": " have moistness, tool laxative effective for oral administration, and have the effect of nourishing.Dressing is made, in protective effect when external is usually used in exfoliation.The wide stomach of " " Traditional Chinese Medicine in Sichuan will ": " energy lung moistening, expelling phlegm for arresting cough.Control cough due to consumptive disease asthma, trusted subordinate against vexed, especially with control dryness, void cough the most suitable." lung moistening is relievingd asthma.Control asthenia cough with asthma, dryness of the intestine constipation.Relatively moisten, control the cough of the deficiency of the lung dryness of the lung.Due to the nutritional labeling such as Semen Armeniacae Amarum rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum.Wherein the content of carotene is only second to Fructus Mangifera Indicae in fruit, and Semen pruni armeniacae is called anticancer fruit by people.Semen pruni armeniacae contains abundant fatty oil, has the effect reducing cholesterol, and therefore, Semen pruni armeniacae has good effect to control cardiovascular system diseases.
Fructus Perillae: pungent, temperature.Return lung, spleen channel.Can relieving the exterior syndrome by diaphoresis, regulating the flow of QI to ease the stomach, solving toxin of fish and crab.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen, fish Eriocheir sinensis is poisoning.Folium Perillae acrid in the mouth warm in nature, have induce sweat, cold expelling, the effect of regulating the flow of vital energy and seeking.Be applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Folium Perillae Herb all has very high nutritive value, and it has low sugar, high microsteping, high carotene, high mineral element etc.Containing perillaldehyde, perilla alcohol, menthone, menthol, eugenol, ergomaketon etc. in volatile oil.Defying age element SOD in every milligram of Folium Perillae content up to 106.2 micrograms.Find after deliberation, the each position of Folium Perillae evenly has good antitumaous effect, especially stronger with the effect in blade, oleanolic acid is wherein a kind of very strong natural anti-cancer agent, there is the effect of prophylaxis of tumours, there is again the effect of antiinflammatory, calmness, heart tonifying, diuresis, enhancing immunity, blood fat reducing and resistance growth of cancer cells.Folium Perillae can diaphoresis cold expelling to separate pathogenic factor in the exterior, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, resolving depression preventing or arresting vomiting, therefore doublely to wind and cold table disease see symptoms of emesis uncomfortable in chest, use this product, be very suitable; Or the smooth symptom of the stagnation of QI is had without table disease, also can be used for a surname logical.
Radix Asteris: warm in nature, bitter in the mouth, pungent.Nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.Cure mainly cough, deficiency of the lung chronic cough, consumptive lung disease lung abscess, coughs vomiting bloody pus, dysuria.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.Be used for the treatment of chronic cough asthma.From Radix Asteris, isolated epifriedelanol has certain antitumaous effect to ehrlich carcinoma, anesthetized rabbit gavages decoct 1 g/kg, have remarkable phlegm-dispelling functions (respiratory tract secretory volume algoscopy), act on sustainable more than 4 hours, crude extract is oral also to be had significantly increasing action rat trachea secretions.In vitro tests has certain inhibitory action to escherichia coli, dysentery bacterium (Song Nei Shi), Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus and vibrio cholera etc.
Flos Farfarae: acrid in the mouth, warm in nature; Return lung meridian." Japan hanako materia medica ": " relieving restlessness, benefit labor is bad, stopping coughing and removing phlegm, and pulmonary fistula is spitted blood, and palpitation with fear of having a guilty conscience, washes liver improving eyesight and apoplexy for profit cardiopulmonary, beneficial the five internal organs." " book on Chinese herbal medicine take advantage of refined half brave ": " Flos Farfarae with controlling cough with dyspnea, kindly breathing heavily, sore throat, because kidney is bitter dry and cold physique drink is cold, begin suitable by being attacked by pathogenic dampness in autumn person.Or burning hot punishment gold, or withering lung lobes with stuffy lung-QI, probably benefit disappears to sparkle and injures." preventing phlegm from forming and stopping coughing.There is the antitussive therapeutic method to keep the adverse QI flowing downwards, the function that lung moistening is eliminated the phlegm.For cough, asthma, consumptive lung disease, coughs the diseases such as blood of spitting.Flower is containing sterols, globulariacitrin, hyperin, triterpenoid saponin, tannin, wax, volatile oil and taraxanthins such as faradiols.Leaf is containing bitterness glycoside 2.63%, gallic acid, gum elastic sample material, dextrin, mucus, inulin, plant sterol, stearic acid and tripalmitin, tartaric acid, malic acid, Nulomoline, choline, Hydrocarbon and Saponin.Collective Notes to the Canon of Materia medica: " Semen Armeniacae Amarum is for making.Obtain Radix Asteris good.Dislike Fructus Gleditsia, Sal Nitri, Radix Scrophulariae.Fear Bulbus Fritillariae Uninbracteatae, Flos Magnoliae, Herba Ephedrae, Radix Scutellariae, Rhizoma Coptidis, Radix Astragali, Herba Celosiae argenteae.”
Semen Ginkgo: ginkgo nut is commonly called as Semen Ginkgo.Property is put down, and sweet in the mouth is pained; Enter lung, kidney channel.Astringe the lung gas, relieving asthma and cough, leukorrhagia stopping is turbid, urine reducing, disinfection.Cure mainly asthma, phlegmatic cough, nocturnal emission, leucorrhea, nebulousurine, infantile diarrhea, malnutrition due to parasitic infestation, hemorrhoidal hamorrhage dysentery, gonorrhea, frequent micturition, and the disease such as scabies, dermatitis rhus, in vain tumor wind.The ginkgolic acid contained in Semen Ginkgo, bilobol, the experiment proved that antibacterial and bactericidal action, can be used for treating respiratory tract infectious disease.Semen Ginkgo water logging agent has inhibitory action in various degree to various fungus, can antipruritic treatment tinea.Ginkgolic acid contained in Semen Ginkgo episperm and bilobol etc., have the effect of anti-mycobacterium tuberculosis.Modern medicine study finds that numerous Semen Ginkgo has the effect of shrinking sphincter vesicae.For bed-wetting, deficiency of vital energy frequent micturition, leukorrhagia nebulousurine, the diseases such as seminal emission is not solid, have the effect of auxiliary treatment.Containing shikimic acid, ginkegetin, isoginkgetin, sterol etc. in Folium Ginkgo, being used for the treatment of the disease such as hypertension and coronary heart diseases and angina pectoris, cerebral vasospasm, hypercholesterolemia in recent years has certain effect.
Folium Elaeagni: acid is flat, nontoxic.Control cough and asthma, hemoptysis, carbuncle, traumatic hemorrhage.Treatment asthma Folium Elaeagni dries, and slow fire is fried to micro-Huang, grinds into powder for subsequent use.Take 1 money with hot rice water at every turn, each 1 time sooner or later, continuous 15 days, can several weeks be taken if desired.Compendium of Material Medica: " the ruined leaf of Pu controls the side of breathing with cough, and goes out " Huatuo's Zhongzang classic ", notably also imitates.Cloud has people to suffer to breathe heavily 30 years, clothes more.After notably taking medicine, on breast, raw little urticaria is had an itch, be then recovered also.Void very adds Radix Ginseng decile, name powder for clearing lung-heat.On the whole it is all got sour and astringent, the merit ear of convergence lung qi dissipation.”
Magnetitum: Xin Xian is flat, nontoxic; Enter kidney channel, Liver Channel, lung meridian." Japan hanako materia medica ": " control eye dusk, muscles and bones is thin and weak, mends five kinds of strain and seven kinds of impairment, except irritated, and detumescence poison." " Mingyi Bielu ": " support kidney to hide, bone strengthening gas, beneficial smart relieving restlessness, gets round by bribery, subduing inflammation scrofula, and neck core is had sore throat, pediatric epilepsy scared." function suppressing the hyperactive liver and subsiding YANG, calm the nerves relieving convulsion, hearing-improing and eyesight improving, helping inspiration to relieve asthma.Main dizzy order flower, deafness, tinnitus, palpitation with fear, insomnia, dyspnea of suffering from a deficiency of the kidney.After rat intravenous injection, hemoglobin level in animal blood, erythrocyte and leukocyte count can be made to increase, blood coagulation time extends and plasma fibrin degrading activity increases, and neutrophil phagocytosis reaction simultaneously increases.Magnetitum concocts rear calmness and anticonvulsant action obviously strengthens.
Cortex Albiziae: sweet, flat; Enter the heart, Liver Channel." Japan hanako materia medica ": " soft extracts, subduing inflammation reuniting the fractured tendons and bones." Shennong's Herbal: " Herba Albiziae, sweet in the mouth is put down.Main settling five organs, sharp will, makes us happy carefree ... raw mountain valley." administration of antiallergic Cortex Albiziae decoct rat oral gavage can suppress its peritoneal mast cells retting conditions, in vitro tests also has similar effect.Cortex Albiziae decoct can obviously suppress antigen (horse serum) to the sensitization process of rat and antibody generation process.Cortex Albiziae is the bark of leguminous plant Herba Albiziae, Cortex Albiziae another name close confused skin, night platform skin, Herba Albiziae veneer, Cortex Albiziae has resolving depression of calming the nerves, the effect of eliminating carbuncle of invigorating blood circulation, Cortex Albiziae have treatment irritability, melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury effect.
Radix Polygalae: bitter, pungent, tepor; GUIXIN, kidney, lung meridian.Shennong's Herbal: ", except pathogen, sharp nine orifices, Fructus Alpiniae Oxyphyllae is intelligent, normal hearing and eyesight, does not forget, strong will times power for main cough with dyspnea damaging the spleen and stomach, tonifying for the deficiency." " Japan hanako materia medica ": " the frightened black mole of main diaphragm gas, longue meat, helps muscles and bones, and married woman's blood is kept silent aphonia, convulsive seizure induced by terror in children." Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Epilepsy mania and irritation, spasm is twitched, skin sore.Modern pharmacological research shows, comparatively skin zone is low for Radix Polygalae xylem haemolysis.Full Radix Polygalae, Radix Polygalae skin, the Radix Polygalae heart all can strengthen syngignoscism when same dosage; Anticonvulsant action is the strongest with full Radix Polygalae, and Radix Polygalae skin takes second place, and the Radix Polygalae heart is invalid; With Radix Polygalae skin the most by force, full Radix Polygalae is taken second place, and the Radix Polygalae heart is the most weak for haemolysis and anxious poison experiment; Full Radix Polygalae compares phlegm-dispelling functions with Radix Polygalae (core removed) and does not weaken.
Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Cortex Magnoliae Officinalis: Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively causes saliva, gastric secretion, gastrointestinal peristalsis to accelerate, and has stomach invigorating digestion-aid effect; The checking of resisting pathogenic microbes acting body exterior-excess is bright, and Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis; Decoct has inhibitory action to Bufo siccus isolated heart. magnocurarine drug administration by injection, having obvious hypotensive effect lower than during muscle relaxant amount, this effect can not by antihistaminic institute antagonism, the blood pressure lowering of Bolos intravenous administration is held time and is about 10 ~ 15 minutes, and the blood pressure lowering of intramuscular administration is held time, and can reach more than 1 hour.The tincture hydrotrope of Flos Magnoliae Officinalis all has hypotensive effect to anesthetized cat, the quiet note of rabbit or intramuscular injection, and can make increased heart rate.
Hericium erinaceus (Bull. Ex Fr.) Pers.: sweet; Flat.Enter spleen, stomach warp.Function cures mainly: strengthening the spleen and nourishing the stomach; Calm the nerves; Anticancer.Main body void is weak; Dyspepsia; Insomnia; Gastroduodenal ulcer; Chronic gastritis; Digestive tract tumor.
Rhizoma Cynanchi Stauntonii: pungent, bitter, tepor.Return lung meridian.Function cures mainly: sending down the abnormal ascending QI, expectorant, cough-relieving.Stop up real for lung qi, cough with copious phlegm, fullness in the chest dyspnea with rapid respiration.
Pericarpium Metaplexis: sweet in the mouth, pungent, property are put down.Return lung; Kidney channel.Function cures mainly: removing heat from the lung and dissipating phlegm; Dissipating blood stasis stops blooding.Main cough with copious phlegm; Asthma; Pertussis; Infantile convulsion; Measles without adequate eruption; Traumatic injury; Traumatic hemorrhage.
Iinum peerenne L.: have the effect restored menstrual flow and invigorated blood circulation, for controlling uterus blood stasis, amenorrhea, physical weakness.
Herba Solani Nigri: bitter, cold.Function cures mainly: heat clearing away, and removing toxic substances, invigorates blood circulation, detumescence.Control furuncle, carbuncle, erysipelas, osteopatia sprain, chronic tracheitis, acute nephritis.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Rhizoma Zingiberis Recens 10-15 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Flos Magnoliae 10-15 weight portion, Herba Centipedae 15-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Lignum Aquilariae Resinatum 10-15 weight portion, Lignum Santali Albi 10-15 weight portion, Fructus Citri Sarcodactylis 15-20 weight portion, Fructus Citri 10-15 weight portion, FLOS MUME 10-18 weight portion, Semen Raphani 10-15 weight portion, Flos Inulae 10-15 weight portion, Rhizoma Cynanchi Stauntonii 10-20 weight portion, Radix Ranunculi Ternati 10-15 weight portion, Semen pruni armeniacae 15-20 weight portion, Fructus Perillae 10-15 weight portion, Radix Asteris 10-15 weight portion, Flos Farfarae 10-20 weight portion, Semen Ginkgo 3-5 weight portion, Folium Elaeagni 10-15 weight portion, Magnetitum 3-5 weight portion, Cortex Albiziae 10-15 weight portion and Radix Polygalae 10-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Rhizoma Zingiberis Recens 13 weight portion, the Radix Angelicae Dahuricae 15 weight portion, Flos Magnoliae 13 weight portion, Herba Centipedae 17 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Lignum Aquilariae Resinatum 12 weight portion, Lignum Santali Albi 12 weight portion, Fructus Citri Sarcodactylis 18 weight portion, Fructus Citri 12 weight portion, FLOS MUME 14 weight portion, Semen Raphani 12 weight portion, Flos Inulae 12 weight portion, Rhizoma Cynanchi Stauntonii 15 weight portion, Radix Ranunculi Ternati 12 weight portion, Semen pruni armeniacae 18 weight portion, Fructus Perillae 12 weight portion, Radix Asteris 12 weight portion, Flos Farfarae 15 weight portion, Semen Ginkgo 4 weight portion, Folium Elaeagni 13 weight portion, Magnetitum 4 weight portion, Cortex Albiziae 12 weight portion and Radix Polygalae 15 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Rhizoma Zingiberis Recens 10-15 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Flos Magnoliae 10-15 weight portion, Herba Centipedae 15-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Lignum Aquilariae Resinatum 10-15 weight portion, Lignum Santali Albi 10-15 weight portion, Fructus Citri Sarcodactylis 15-20 weight portion, Fructus Citri 10-15 weight portion, FLOS MUME 10-18 weight portion, Semen Raphani 10-15 weight portion, Flos Inulae 10-15 weight portion, Rhizoma Cynanchi Stauntonii 10-20 weight portion, Radix Ranunculi Ternati 10-15 weight portion, Semen pruni armeniacae 15-20 weight portion, Fructus Perillae 10-15 weight portion, Radix Asteris 10-15 weight portion, Flos Farfarae 10-20 weight portion, Semen Ginkgo 3-5 weight portion, Folium Elaeagni 10-15 weight portion, Magnetitum 3-5 weight portion, Cortex Albiziae 10-15 weight portion, Radix Polygalae 10-18 weight portion, Ganoderma 10-20 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Hericium erinaceus (Bull. Ex Fr.) Pers. 15-20 weight portion, Rhizoma Cynanchi Stauntonii 15-20 weight portion, Pericarpium Metaplexis 15-20 weight portion, Iinum peerenne L. 10-15 weight portion and Herba Solani Nigri 15-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Rhizoma Zingiberis Recens 13 weight portion, the Radix Angelicae Dahuricae 15 weight portion, Flos Magnoliae 13 weight portion, Herba Centipedae 17 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Lignum Aquilariae Resinatum 12 weight portion, Lignum Santali Albi 12 weight portion, Fructus Citri Sarcodactylis 18 weight portion, Fructus Citri 12 weight portion, FLOS MUME 14 weight portion, Semen Raphani 12 weight portion, Flos Inulae 12 weight portion, Rhizoma Cynanchi Stauntonii 15 weight portion, Radix Ranunculi Ternati 12 weight portion, Semen pruni armeniacae 18 weight portion, Fructus Perillae 12 weight portion, Radix Asteris 12 weight portion, Flos Farfarae 15 weight portion, Semen Ginkgo 4 weight portion, Folium Elaeagni 13 weight portion, Magnetitum 4 weight portion, Cortex Albiziae 12 weight portion, Radix Polygalae 15 weight portion, Ganoderma 15 weight portion, Cortex Magnoliae Officinalis 17 weight portion, Hericium erinaceus (Bull. Ex Fr.) Pers. 17 weight portion, Rhizoma Cynanchi Stauntonii 18 weight portion, Pericarpium Metaplexis 18 weight portion, Iinum peerenne L. 12 weight portion and Herba Solani Nigri 17 weight portion.
When the dosage form of Chinese medicine composition is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
When the dosage form of Chinese medicine composition is oral liquid, its preparation method comprises the following steps:
The first step, by Pericarpium Citri Reticulatae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Citri Sarcodactylis, Fructus Citri, FLOS MUME and Semen Raphani mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 4 times, each 3 ~ 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.36 ~ 1.38, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 8 times of water gagings, boils 3 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.34;
3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 60 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 tablet
Embodiments provide a kind of Chinese medicine composition being used for the treatment of bronchial asthma, the parts by weight of its each raw medicinal material are: Rhizoma Zingiberis Recens 13 weight portion, the Radix Angelicae Dahuricae 15 weight portion, Flos Magnoliae 13 weight portion, Herba Centipedae 17 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Lignum Aquilariae Resinatum 12 weight portion, Lignum Santali Albi 12 weight portion, Fructus Citri Sarcodactylis 18 weight portion, Fructus Citri 12 weight portion, FLOS MUME 14 weight portion, Semen Raphani 12 weight portion, Flos Inulae 12 weight portion, Rhizoma Cynanchi Stauntonii 15 weight portion, Radix Ranunculi Ternati 12 weight portion, Semen pruni armeniacae 18 weight portion, Fructus Perillae 12 weight portion, Radix Asteris 12 weight portion, Flos Farfarae 15 weight portion, Semen Ginkgo 4 weight portion, Folium Elaeagni 13 weight portion, Magnetitum 4 weight portion, Cortex Albiziae 12 weight portion and Radix Polygalae 15 weight portion.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 85%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 350 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.2 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.
Embodiment 2 oral liquid
Embodiments provide a kind of Chinese medicine composition being used for the treatment of bronchial asthma, the parts by weight of its each raw medicinal material are: Rhizoma Zingiberis Recens 13 weight portion, the Radix Angelicae Dahuricae 15 weight portion, Flos Magnoliae 13 weight portion, Herba Centipedae 17 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Lignum Aquilariae Resinatum 12 weight portion, Lignum Santali Albi 12 weight portion, Fructus Citri Sarcodactylis 18 weight portion, Fructus Citri 12 weight portion, FLOS MUME 14 weight portion, Semen Raphani 12 weight portion, Flos Inulae 12 weight portion, Rhizoma Cynanchi Stauntonii 15 weight portion, Radix Ranunculi Ternati 12 weight portion, Semen pruni armeniacae 18 weight portion, Fructus Perillae 12 weight portion, Radix Asteris 12 weight portion, Flos Farfarae 15 weight portion, Semen Ginkgo 4 weight portion, Folium Elaeagni 13 weight portion, Magnetitum 4 weight portion, Cortex Albiziae 12 weight portion, Radix Polygalae 15 weight portion, Ganoderma 15 weight portion, Cortex Magnoliae Officinalis 17 weight portion, Hericium erinaceus (Bull. Ex Fr.) Pers. 17 weight portion, Rhizoma Cynanchi Stauntonii 18 weight portion, Pericarpium Metaplexis 18 weight portion, Iinum peerenne L. 12 weight portion and Herba Solani Nigri 17 weight portion.
Its preparation method comprises the following steps:
The first step, by Pericarpium Citri Reticulatae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Citri Sarcodactylis, Fructus Citri, FLOS MUME and Semen Raphani mixing, add relative to mixture 7 times amount determining alcohol be 90% alcohol reflux 2 ~ 4 times, each 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times of water gagings, boils 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.33;
3rd step, the described mastic mixing that the first step, second step are obtained, 75 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 36 hours, and refrigerated storage temperature is 5 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.004; The time of described heat treated is 75 minutes, and temperature is 160 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
Toxicity test
Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore Chinese medicine Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: by the Oral Liquid On Mice of the embodiment of the present invention 2 by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data
Case selection: fetch the patient coming from the routine bronchial asthma of the court patient 240, man 108 example, female 132 example, age 21-68 year, 40.7 years old mean age, the course of disease 6 months-15 years.240 routine patient armies are diagnosed as bronchial asthma, and all go to a doctor in stage of attack, disease time is 2-10 days.240 routine patients are divided into three groups at random, are respectively embodiment group 1, embodiment group 2 and matched group, often organize 80 people.Between each experimental group in the physical data such as sex, age, disease degree without obvious significant difference, there is comparability.
Diagnostic criteria: 1, the panting of recurrent exerbation, dyspnea, uncomfortable in chest or cough, how with to contact allergen, cold air, physical chemistry sexual stimulus, viral upper respiratory tract infection or motion etc. relevant; 2, during outbreak at two lung audible and be dispersed in or diffusivity, to breathe wheezing sound mutually, expiratory phase prolongation; 3, atypical symptom (as without obviously panting or sign) should at least possess with the next item down test positive: a, brinchial provocation test or exercise test are positive, b, the Bronchodilatation test positive (one second forced expiratory volume (FEV 1) increase by more than 15%, and FEV 1increase, absolute value > 200ml), c, maximal expiratory flow (PEF) be aberration rate or day and night fluctuation rate>=20% in day; Panting 4, caused by other diseases, uncomfortable in chest or cough.
Therapeutic Method:
Embodiment group 1: the tablet taking the embodiment of the present invention 1, every day 3 times, each 37 days is a course for the treatment of;
Embodiment group 2: the oral liquid taking the embodiment of the present invention 2, every day 3 times, each 10ml 7 days is a course for the treatment of;
Matched group: oral hydrochloride ambroxol oral liquid, every day 2 times, each 10ml 7 days is a course for the treatment of.
The standard of curative effect evaluation: the bronchial asthma curative effect judging standard formulated with reference to national asthma meeting.Clinical cure: symptoms of asthma complete incidence graph, has mild episode even if even, does not need medication to alleviate; Effective: asthma attack obviously alleviates before comparatively treating, idol diastole bronchus Chinese medicine composition or use this Serial Prescription medicine and alleviate and pant; Take a turn for the better: symptoms of asthma alleviates to some extent, but still often needs traditional Chinese medicine composition for treating; Invalid: after treatment, symptom and sign is without improving or increasing the weight of.
Therapeutic outcome:
See table 1 and table 2, as can be seen from Table 1, adopt traditional Chinese medicine composition for treating bronchial asthma of the present invention, relative to Chinese medicine composition on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt traditional Chinese medicine composition for treating bronchial asthma of the present invention, relative to Chinese medicine compositions, treatment the course for the treatment of on significantly shorten.
After each experimental group of table 1 treats 8 courses for the treatment of respectively, Clinical efficacy comparison is routine
Group Number of cases Clinical cure Effective Take a turn for the better Invalid Cure and obvious effective rate Total effective rate
Embodiment group 1 80 34 36 10 0 （70）87.5% 100%
Embodiment group 2 80 35 37 8 0 （72）90.0% 100%
Matched group 80 11 33 29 7 （44）55.0% 91.25%
The each experimental group of table 2 treats clinical cure and effective number and time comparative example (%) after 8 courses for the treatment of respectively
Group Number of cases 1-3 the course for the treatment of 4-6 the course for the treatment of 7-8 the course for the treatment of
Embodiment group 1 70 8（11.4%） 38（54.3%） 24（34.3%）
Embodiment group 2 72 9（12.5%） 39（54.2%） 24（33.3%）
Matched group 44 2（4.5%） 19（43.2%） 23（52.3%）
According to the clinical statistics in above table, Chinese medicine composition provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Simultaneously to each experimental group clinical cure and effective follow-up of patients's half a year, result is added up, 70 examples in embodiment group 1, and 34 examples of healing are without recurrence, and have 1 example recurrence in 36 effective examples, relapse rate is 1.4%; 72 examples in embodiment group 2 are without recurrence, and in matched group 44 example, have 1 example recurrence in 11 examples of healing, have 4 example recurrences in 33 effective examples, relapse rate is 11.4%.
Model case: together certain, female, 63 years old, dyspnea and uncomfortable in chest, coughed after getting up morning comparatively serious, it is many that above-mentioned symptom continues half a year, medical difficulty of a few days ago panting, at two lung audible and be dispersed in or diffusivity, to breathe wheezing sound mutually during outbreak, expiratory phase extends, and brinchial provocation test or the exercise test positive are diagnosed as bronchial asthma disease.Taking the oral liquid of the embodiment of the present invention 2, every day 3 times, each 10ml, 7 days is a course for the treatment of, takes two courses for the treatment of continuously, clinical recovery, follows up a case by regular visits to and do not recur half a year.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (5)

1. one kind is used for the treatment of the Chinese medicine composition of bronchial asthma, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Rhizoma Zingiberis Recens, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Pericarpium Citri Reticulatae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Citri Sarcodactylis, Fructus Citri, FLOS MUME, Semen Raphani, Flos Inulae, Rhizoma Cynanchi Stauntonii, Radix Ranunculi Ternati, Semen pruni armeniacae, Fructus Perillae, Radix Asteris, Flos Farfarae, Semen Ginkgo, Folium Elaeagni, Magnetitum, Cortex Albiziae, Radix Polygalae, Ganoderma, Cortex Magnoliae Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Rhizoma Cynanchi Stauntonii, Pericarpium Metaplexis, Iinum peerenne L. and Herba Solani Nigri.
2. the Chinese medicine composition being used for the treatment of bronchial asthma according to claim 1, is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Rhizoma Zingiberis Recens 10-15 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Flos Magnoliae 10-15 weight portion, Herba Centipedae 15-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Lignum Aquilariae Resinatum 10-15 weight portion, Lignum Santali Albi 10-15 weight portion, Fructus Citri Sarcodactylis 15-20 weight portion, Fructus Citri 10-15 weight portion, FLOS MUME 10-18 weight portion, Semen Raphani 10-15 weight portion, Flos Inulae 10-15 weight portion, Rhizoma Cynanchi Stauntonii 10-20 weight portion, Radix Ranunculi Ternati 10-15 weight portion, Semen pruni armeniacae 15-20 weight portion, Fructus Perillae 10-15 weight portion, Radix Asteris 10-15 weight portion, Flos Farfarae 10-20 weight portion, Semen Ginkgo 3-5 weight portion, Folium Elaeagni 10-15 weight portion, Magnetitum 3-5 weight portion, Cortex Albiziae 10-15 weight portion, Radix Polygalae 10-18 weight portion, Ganoderma 10-20 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Hericium erinaceus (Bull. Ex Fr.) Pers. 15-20 weight portion, Rhizoma Cynanchi Stauntonii 15-20 weight portion, Pericarpium Metaplexis 15-20 weight portion, Iinum peerenne L. 10-15 weight portion and Herba Solani Nigri 15-20 weight portion.
3. the Chinese medicine composition being used for the treatment of bronchial asthma according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Rhizoma Zingiberis Recens 13 weight portion, the Radix Angelicae Dahuricae 15 weight portion, Flos Magnoliae 13 weight portion, Herba Centipedae 17 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Lignum Aquilariae Resinatum 12 weight portion, Lignum Santali Albi 12 weight portion, Fructus Citri Sarcodactylis 18 weight portion, Fructus Citri 12 weight portion, FLOS MUME 14 weight portion, Semen Raphani 12 weight portion, Flos Inulae 12 weight portion, Rhizoma Cynanchi Stauntonii 15 weight portion, Radix Ranunculi Ternati 12 weight portion, Semen pruni armeniacae 18 weight portion, Fructus Perillae 12 weight portion, Radix Asteris 12 weight portion, Flos Farfarae 15 weight portion, Semen Ginkgo 4 weight portion, Folium Elaeagni 13 weight portion, Magnetitum 4 weight portion, Cortex Albiziae 12 weight portion, Radix Polygalae 15 weight portion, Ganoderma 15 weight portion, Cortex Magnoliae Officinalis 17 weight portion, Hericium erinaceus (Bull. Ex Fr.) Pers. 17 weight portion, Rhizoma Cynanchi Stauntonii 18 weight portion, Pericarpium Metaplexis 18 weight portion, Iinum peerenne L. 12 weight portion and Herba Solani Nigri 17 weight portion.
4. the preparation method being used for the treatment of the Chinese medicine composition of bronchial asthma according to any one of claim 1-3, is characterized in that, the dosage form of described Chinese medicine composition is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
5. the preparation method being used for the treatment of the Chinese medicine composition of bronchial asthma according to any one of claim 1-4, is characterized in that, the dosage form of described Chinese medicine composition is oral liquid, and its preparation method comprises the following steps:
The first step, by Pericarpium Citri Reticulatae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Citri Sarcodactylis, Fructus Citri, FLOS MUME and Semen Raphani mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 4 times, each 3 ~ 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.36 ~ 1.38, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 8 times of water gagings, boils 3 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.34;
3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 60 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
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