CN103301400A - Traditional Chinese medicinal composition for treating chronic atrophic gastritis and preparation method of traditional Chinese medicinal composition - Google Patents

Abstract

The invention discloses a traditional Chinese medicinal composition for treating chronic atrophic gastritis. The traditional Chinese medicinal composition is prepared from the following crude medicines in parts by weight: 40 parts of radix pseudostellariae, 50 parts of dendrobe, 5 parts of pseudo-ginseng, 40 parts of curcuma zedoary, 40 parts of radix curcumae, 20 parts of radix paeoniae alba, 40 parts of oldenlandia diffusa, 45 parts of dandelion, 45 parts of sculellaria barbata, 10 parts of mangnolia officinalis, 7 parts of agastache rugosus, 7 parts of eupatorium, 7 parts of pericarpium citri reticulatae, 8 parts of pinellia ternata, 8 parts of costus root, 8 parts of fructus amomi, 8 parts of cattail pollen, 8 parts of trogopterus dung, 4 parts of liquorice, 10 parts of cassia twig, 10 parts of caulis bambusae in taeniam, 30 parts of reed rhizome, 10 parts of bitter orange, 10 parts of radix ophiopogonis and 20 parts of honeysuckle. The traditional Chinese medicinal composition is rational in formula, and various traditional Chinese medicines take a synergistic action to enhance therapeutic effect which, in comparison with Western medicine, is more excellent; the traditional Chinese medicinal composition treats both symptoms and root causes, and is high in cure rate, low in recurrence rate, light in irritation to stomach; the composition relieves body burden.

Description

A kind of Chinese medicine composition and preparation method for the treatment of chronic atrophic gastritis

Technical field

The invention belongs to technical field of Chinese medicines, specifically a kind of Chinese medicine composition and preparation method for the treatment of chronic atrophic gastritis.

Background technology

In digestive system disease, gastritis is comparatively common disease, account for clinical patient affected by inspection's 13%, and sickness rate raises along with the increase at age, gastric epithelial after the infringement of suffering repeatedly so that intrinsic body of gland atrophy or the disappearance of mucosa, produce pathological changes, the normal companion of serious atrophic gastritis sees that intestinal epithelial metaplasia or atypical hyperplasia are arranged, might develop into gastric cancer, gastric mucosa atrophy is intestinal epithelial metaplasia atypical hyperplasia gastric cancer one by one one by one one by one, be considered to a kind of progressive process that gastric cancer occurs, so people are called a kind of of disease before the Stomach Carcinomas with atrophic gastritis in recent years.

Chronic atrophic gastritis is a kind of commonly encountered diseases, refers to that gastric mucosa loss of function atrophy and change are living, often involves cardia, reduce with the forfeiture of G cell and gastrin secretion, also can involve body of stomach, with the forfeiture of secreting acid gland, cause gastric acid, the minimizing of pepsin and endogenous factors.

The medicine that is used for the treatment of chronic atrophic gastritis has many kinds; Generally be divided into Chinese medicine and Western medicine, adopt the western medicine chronic atrophic gastritis, side effect is larger, and larger to the infringement of human body, therapeutic effect is undesirable; Because Chinese medicine has little, the eutherapeutic characteristics of side effect, therefore favored by people.

Summary of the invention

The problem to be solved in the present invention is for above problem, provides the cure rate high relapse rate low a kind of Chinese medicine composition and preparation method for the treatment of chronic atrophic gastritis.

For addressing the above problem, the technical solution adopted in the present invention is:

A kind of Chinese medicine composition for the treatment of chronic atrophic gastritis is got the crude drug of following parts by weight: 40 parts of Radix Pseudostellariaes, 50 parts of Herba Dendrobiis, 5 parts of Radix Notoginseng, 40 parts of Rhizoma Curcumae, 40 parts of Radix Curcumaes, 20 parts of the Radix Paeoniae Albas, 40 parts of Herba Hedyotidis Diffusaes, 45 parts of Herba Taraxacis, 45 parts of Herba Scutellariae Barbataes, 10 parts of Cortex Magnoliae Officinalis, 7 parts of Herba Pogostemoniss, 7 parts of Herba Eupatoriis, 7 parts of Pericarpium Citri Reticulataes, 8 parts of the Rhizoma Pinelliaes, 8 parts of the Radix Aucklandiae, 8 parts of Fructus Amomis, 8 parts of Pollen Typhaes, 8 parts of Oletum Trogopteroris, 4 parts in Radix Glycyrrhizae; 10 parts of Ramulus Cinnamomi, 10 parts of Caulis Bambusae In Taenia, 30 parts of Rhizoma Phragmitiss, 10 parts of Fructus Aurantiis, 10 parts of Radix Ophiopogonis, 20 parts of Flos Loniceraes.

A kind of preparation method for the treatment of the Chinese medicine composition of chronic atrophic gastritis may further comprise the steps:

1) gets Herba Dendrobii, Radix Notoginseng, the Radix Paeoniae Alba, Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Scutellariae Barbatae, Cortex Magnoliae Officinalis, Herba Pogostemonis, Herba Eupatorii, the Rhizoma Pinelliae, the Radix Aucklandiae, Fructus Amomi, Pollen Typhae, Oletum Trogopterori, Radix Glycyrrhizae, Ramulus Cinnamomi, Caulis Bambusae In Taenia, Rhizoma Phragmitis, Radix Ophiopogonis, the Flos Lonicerae of above-mentioned weight portion, the decocting that adds 10 times of total raw material medicine weight boils, leach medicinal liquid, get medicinal liquid A;

After Radix Pseudostellariae, Rhizoma Curcumae, Radix Curcumae, Pericarpium Citri Reticulatae, the Fructus Aurantii of 2) getting above-mentioned weight portion extracted volatile oil respectively, the decocting that medicinal residues add up 5 times of crude drug weight boiled, and decoction liquor is centrifugal, gets supernatant, gets extracting solution B;

3) merge above-mentioned medicinal liquid A and extracting solution B, stir, get extracting solution C after the filtration;

When 4) extracting solution C being heated to 70 degrees centigrade, add step 2) volatile oil that makes, stir, make medicine.

Radix Pseudostellariae, Herba Dendrobii, Radix Notoginseng, Rhizoma Curcumae, Fructus Amomi, Ramulus Cinnamomi, Radix Ophiopogonis, Flos Lonicerae had the effect that strengthens the spleen and stomach; Radix Curcumae has the analgesic effect, the Radix Paeoniae Alba, Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Scutellariae Barbatae, the effect of heat-clearing and toxic substances removing, warming the meridian and promoting blood circulation; Cortex Magnoliae Officinalis, Herba Pogostemonis, Herba Eupatorii, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, the Radix Aucklandiae, Pollen Typhae, Oletum Trogopterori, Radix Glycyrrhizae; Effect pleasant, hemostatic analgesia that Caulis Bambusae In Taenia, Rhizoma Phragmitis have.

Through clinical trial, the present embodiment has good curative effect to the treatment chronic atrophic gastritis, is difficult for recurrence, and has no side effect, and does not develop immunity to drugs, and be 15 days each course for the treatment of, can cure after taking 2 to 3 courses for the treatment of, and cure rate reaches more than 83%, and relapse rate is lower.

The rational compatibility of the present invention's process, the synergism of each Chinese medicine, therapeutic effect is remarkable, compares with using Western medicine, is better than Western medicine, takes stopgap measures and effects a permanent cure, and cure rate is high, and relapse rate is low, and treatment by Chinese herbs is less to the zest of stomach, alleviates body burden.

The specific embodiment

Embodiment, a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis is got the crude drug of following parts by weight: Radix Pseudostellariae 40 grams, Herba Dendrobii 50 grams, Radix Notoginseng 5 grams, Rhizoma Curcumae 40 grams, Radix Curcumae 40 grams, the Radix Paeoniae Alba 20 grams, Herba Hedyotidis Diffusae 40 grams, Herba Taraxaci 45 grams, Herba Scutellariae Barbatae 45 grams, Cortex Magnoliae Officinalis 10 grams, Herba Pogostemonis 7 grams, Herba Eupatorii 7 grams, Pericarpium Citri Reticulatae 7 grams, the Rhizoma Pinelliae 8 grams, the Radix Aucklandiae 8 grams, Fructus Amomi 8 grams, Pollen Typhae 8 grams, Oletum Trogopterori 8 grams, Radix Glycyrrhizae 4 grams; Ramulus Cinnamomi 10 grams, Caulis Bambusae In Taenia 10 grams, Rhizoma Phragmitis 30 grams, Fructus Aurantii 10 grams, restrain Radix Ophiopogonis 10, Flos Lonicerae 20 grams.

A kind of preparation method for the treatment of the Chinese medicine composition of chronic atrophic gastritis may further comprise the steps:

1) gets Herba Dendrobii, Radix Notoginseng, the Radix Paeoniae Alba, Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Scutellariae Barbatae, Cortex Magnoliae Officinalis, Herba Pogostemonis, Herba Eupatorii, the Rhizoma Pinelliae, the Radix Aucklandiae, Fructus Amomi, Pollen Typhae, Oletum Trogopterori, Radix Glycyrrhizae, Ramulus Cinnamomi, Caulis Bambusae In Taenia, Rhizoma Phragmitis, Radix Ophiopogonis, the Flos Lonicerae of above-mentioned weight, the decocting that adds 10 times of total raw material medicine weight boils, leach medicinal liquid, get medicinal liquid A;

After Radix Pseudostellariae, Rhizoma Curcumae, Radix Curcumae, Pericarpium Citri Reticulatae, the Fructus Aurantii of 2) getting above-mentioned weight extracted volatile oil respectively, the decocting that medicinal residues add up 5 times of crude drug weight boiled, and decoction liquor is centrifugal, gets supernatant, gets extracting solution B;

3) merge above-mentioned medicinal liquid A and extracting solution B, stir, get extracting solution C after the filtration;

When 4) extracting solution C being heated to 70 degrees centigrade, add step 2) volatile oil that makes, stir, make medicine.

The medicine that makes is divided into two parts, and a minute morning and evening takes, and 15 days is a course for the treatment of, and can fully recover general 2-3 course for the treatment of, and period in a medicine is avoided pungent meat or fish,

For further investigating clinical efficacy and the safety of the present embodiment medicine, we have selected the case of 300 routine chronic gastritiss that the treatment curative effect of medicine of the present invention is carried out clinical trial.

The patient of 300 routine chronic atrophic gastritis is divided into two groups at random, every group of 150 examples.In the matched group, male's 81 examples, women's 69 examples; 30～40 years old age, 20 examples, 41～50 years old 51 example, 51～60 years old 48 example, 61～70 years old 28 example, 3 examples more than 70 years old; In the treatment group, male's 85 examples, women's 65 examples; 30～40 years old age, 18 examples, 41～50 years old 52 example, 51～60 years old 45 example, 61～70 years old 29 example, 6 examples more than 70 years old.

Two groups of cases are Epidemiological Analysis by statistics at aspects such as sex, age, the courses of disease, has comparability.

Matched group adopts appropriate exercise, and rational diet adopts traditional Western medicine to treat; The oral medicine of the present invention for the treatment of group divides to take night and morning, and takes 3 courses for the treatment of.

Criterion of therapeutical effect: cure: clinical symptoms, sign disappear, the gastritis transference cure, and stomach is comfortable, has no adverse reaction.Produce effects: clinical symptoms, sign obviously alleviate, and the gastritis symptom obviously alleviates, and the symptom such as have a stomach-ache obviously alleviates, and hemogram is normal.Effectively: clinical symptoms, sign alleviate, the gastritis sx↓.Invalid: clinical symptoms, sign are not improved.Relapse rate: the probability that within 1 year, recurs again after curing.Curative effect comparision result such as table one after two groups of cases are treated.

Table one

Group

The example number

Cure n(%)

Produce effects n(%)

Effective n(%)

Invalid n(%)

Relapse rate n(%)

Matched group

150

100（66.7）

120（80.0）

130（86.7）

20（13.3）

20（33.3）

Treatment group

150

125（83.3）

145（96. 7）

148（98.7）

2（1.33）

13（8.7）

By above-mentioned contrast, can find out and use treatment by Chinese herbs chronic atrophic gastritis of the present invention, therapeutic effect is remarkable, compares with using Western medicine, is better than Western medicine, takes stopgap measures and effects a permanent cure, and cure rate is high, and relapse rate is low, and treatment by Chinese herbs is less to the zest of stomach, alleviates body burden.

The present invention has good curative effect to the treatment chronic atrophic gastritis, is difficult for recurrence, and has no side effect, and does not develop immunity to drugs, and be 15 days each course for the treatment of, can cure after taking 2 to 3 courses for the treatment of, and cure rate reaches more than 83.3%, and relapse rate is lower, only is about 8.7%.

Some patients were healing case is as follows:

The field, the woman, 52 years old, suffer from chronic atrophic gastritis, be distending pain, dull pain, dull pain, severe pain or angor during outbreak, the scorching hot or noisy discomfort of the conscious gastral cavilty of patient section.Loss of appetite usually appears, even without appetite, though or appetite feed aftersensation gastral cavilty section's distension discomfort or dyspepsia are arranged, give the present embodiment after 2 courses for the treatment of, patient's transference cure, recovery from illness, so far recurrence.

Jiang, man, 32 years old, suffer from chronic atrophic gastritis, gastral cavilty section distension is uncomfortable, and some patients feel that there is the sense of obstruction in the vexed or gastral cavilty section of stomach painful abdominal mass, abdominal part, side of body flank, chest are also felt distension, and belch is frequent, the scorching hot or noisy discomfort of the conscious gastral cavilty of patient section, loss of appetite usually appears, even without appetite, give the present embodiment after 3 courses for the treatment of, patient's transference cure, recovery from illness, so far not recurrence.

The river, woman 45 years old suffers from chronic atrophic gastritis, the scorching hot or noisy discomfort of the conscious gastral cavilty of patient section, loss of appetite usually occurs, even without appetite, stomach severe pain or angor during outbreak give the present embodiment after 2 courses for the treatment of, patient's transference cure, recovery from illness, so far not recurrence.

Weigh certain, man 50 years old suffers from chronic atrophic gastritis, scorching hot or the noisy discomfort of the conscious gastral cavilty of patient section, loss of appetite usually appears, even without appetite, stomach severe pain or angor during outbreak, abdominal part, side of body flank, chest are also felt distension, belch is frequent, gives the present embodiment after 3 courses for the treatment of, patient's transference cure, recovery from illness, so far not recurrence.

Claims (2)

1. a Chinese medicine composition for the treatment of chronic atrophic gastritis is characterized in that: the crude drug of getting following parts by weight: 40 parts of Radix Pseudostellariaes, 50 parts of Herba Dendrobiis, 5 parts of Radix Notoginseng, 40 parts of Rhizoma Curcumae, 40 parts of Radix Curcumaes, 20 parts of the Radix Paeoniae Albas, 40 parts of Herba Hedyotidis Diffusaes, 45 parts of Herba Taraxacis, 45 parts of Herba Scutellariae Barbataes, 10 parts of Cortex Magnoliae Officinalis, 7 parts of Herba Pogostemoniss, 7 parts of Herba Eupatoriis, 7 parts of Pericarpium Citri Reticulataes, 8 parts of the Rhizoma Pinelliaes, 8 parts of the Radix Aucklandiae, 8 parts of Fructus Amomis, 8 parts of Pollen Typhaes, 8 parts of Oletum Trogopteroris, 4 parts in Radix Glycyrrhizae; 10 parts of Ramulus Cinnamomi, 10 parts of Caulis Bambusae In Taenia, 30 parts of Rhizoma Phragmitiss, 10 parts of Fructus Aurantiis, 20 parts of 10 parts of Radix Ophiopogonis and Flos Loniceraes.

2. the preparation method of the Chinese medicine composition of a kind for the treatment of chronic atrophic gastritis as claimed in claim 1 is characterized in that: may further comprise the steps

1) gets Herba Dendrobii, Radix Notoginseng, the Radix Paeoniae Alba, Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Scutellariae Barbatae, Cortex Magnoliae Officinalis, Herba Pogostemonis, Herba Eupatorii, the Rhizoma Pinelliae, the Radix Aucklandiae, Fructus Amomi, Pollen Typhae, Oletum Trogopterori, Radix Glycyrrhizae, Ramulus Cinnamomi, Caulis Bambusae In Taenia, Rhizoma Phragmitis, Radix Ophiopogonis and the Flos Lonicerae of above-mentioned weight portion, the decocting that adds 10 times of weight portions of total raw material medicine boils, leach medicinal liquid, get medicinal liquid A;

Radix Pseudostellariae, Rhizoma Curcumae, Radix Curcumae, Pericarpium Citri Reticulatae, the Fructus Aurantii of 2) getting above-mentioned weight portion are extracted respectively volatile oil, and the decocting that medicinal residues add up 5 times of weight portions of crude drug boils, and decoction liquor is centrifugal, gets supernatant, gets extracting solution B;

3) merge above-mentioned medicinal liquid A and extracting solution B, stir, get extracting solution C after the filtration;

When 4) extracting solution C being heated to 70 degrees centigrade, add step 2) volatile oil that makes, stir, make medicine.