CN104367913A

CN104367913A - Pharmaceutical composition for treating superficial gastritis as well as preparation method thereof

Info

Publication number: CN104367913A
Application number: CN201410595173.2A
Authority: CN
Inventors: 张恩荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-10-30
Filing date: 2014-10-30
Publication date: 2015-02-25

Abstract

The invention relates to a pharmaceutical composition for treating superficial gastritis as well as a preparation method thereof. The pharmaceutical composition is prepared from the following traditional Chinese medicinal materials in parts by weight: Kadsura coccinea, erythrina indica, holly roots, ovateleaf holly barks, longan tree loranthaceae tea, parasitic sand pear trees, water banyan wood parasitic tea, beautiful millettia roots, arrowleaf abelmoschus roots, perny false fairybells rhizome, Chinese fan palms, robbers in the greenwoods, Clausena excavata Burm., dried tangerine, solanum lyratum, Chinese lobelia, sculellaria barbata, oldenlandia diffusa, hairyvein agrimony, agastache rugosus and dendrobe. The pharmaceutical composition provided by the invention can be used for treating clinical symptoms such as discomfort and dull pain of middle upper abdomen, burning pain, flautulence, inappetence, eructation, acid regurgitation, nausea and the like caused by superficial gastritis.

Description

Pharmaceutical composition for the treatment of superficial gastritis and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines for the treatment of, be specifically related to pharmaceutical composition for the treatment of superficial gastritis and preparation method thereof.

Background technology

The disease of chronic superficial gastritis to be gastric mucosa be chronic superficial inflammation, is digestive system commonly encountered diseases, belongs to the one in chronic gastritis.Can because being addicted to drink, drinking espresso, bile reflux, or cause because of helicobacter pylori infections etc.Patient can have indigestion symptom in various degree, as epigastric discomfort, dull pain after taking food, companion's belch, feel sick, pantothenic acid, occasionally have vomiting.

The paathogenic factor of superficial gastritis is not yet completely clear so far, and the wherein clearer and more definite cause of disease has: 1. antibacterial, virus and toxin.2. smoking.3. medicine, some drugs, as Salicylic Acid Formulations, 17-hydroxy-11-dehydrocorticosterone, Folium Digitalis Purpureae, indometacin, Phenylbutazone etc., can cause chronic gastric mucosa lesions.4. irritable food.5. circulation and metabolic dysfunction.6. bile or Duodenal reflux.7. helicobacter pylori (Hp) infects.8. psychological factor.

Chronic superficial gastritis clinical manifestation is:

1. upper abdominal pain.Most common sympton is Upper abdominal pain, and most of chronic superficial gastritis patient has this symptom.Epigastrium pain majority is irregular, has nothing to do with diet.Pain is generally diffusivity epigastrium causalgia, dull pain, distending pain etc.Usually because eaten cold drinks and snachs, hard food, pungent or other irritable foods and exacerbation of symptoms, minority is relevant with climate change.

2. abdominal distention.Chronic superficial gastritis patient has abdominal distention more.Usually because gastric retention food, emptying delay, caused by dyspepsia.

3. belch.Patient has belch.Show that gastric gas increases, discharge through esophagus, make Abdeminal pain respite.

4. Repeated Hemorrhage is common sympton.Cause of bleeding is that a kind of gastric mucosa acute inflammation concurrent on chronic superficial gastritis basis changes.

5. other.Inappetence, acid regurgitation, Nausea and vomiting, weak, constipation or diarrhoea etc.

6. sign.Have upper abdomen tenderness during inspection, small number of patients can be become thin and anemia.

Conventional Therapeutic Method has:

1. eliminate the cause of disease

2. Drug therapy

(1) the conventional medicine of gastric mucosa medicine is protected to have colloidal bismuth subcitrate (CBS), sucralfate, dioctahedral smectite, Marzulene-S, gel aluminum hydroxide, gastric Mucin and gavirin tablet etc.

(2) gastrointestinal motility function medicament Abdeminal pain metoclopramide or domperidone etc. is adjusted.Have the hiccups, abdominal distention or have reflux phenomenon to be main person, available medicine for stomach dynamic, as metoclopramide, dompendone, not husky Billy.

(3) if antibiotic gastroscopy finds Helicobacter pylori, should antibiotic be taken, clarithromycin, amoxicillin etc., have and remove the effect of Hp, generally can select two kinds, normal and gastric mucosa protective agent and antacid use in conjunction.

(4) medicine that antacid is conventional has cimetidine, ranitidine, famotidine, sodium bicarbonate (sodium bicarbonate), magnesium hydroxide, gel aluminum hydroxide, gavirin tablet etc.

(5) analgesic Upper abdominal pain is good to eat compared with severe one takes atropine, probanthine, Semen daturae tablet or 654-2, to reduce gastric acid secretion and to alleviate colic symptoms.

(6) also available digestant as pancreatin, yeast tablet, lactasinum, flatulence relieving tablet etc.Also can with acid suppression medicine as safe stomach U.S., ranitidine, famotidine etc. if any acid regurgitation phenomenon.Prevent bile reflux from can take hydrotalcite, cholestyramine to adsorb gallbladder juice; Have the hematemesis person of having blood in stool, cimetidine is oral.

Summary of the invention

The object of this invention is to provide a kind of pharmaceutical composition for the treatment of superficial gastritis;

Another object of the present invention is to provide a kind of preparation method for the treatment of the pharmaceutical composition of superficial gastritis.

The object of the invention is by following technical scheme realize:

The pharmaceutical composition for the treatment of superficial gastritis of the present invention, it is prepared from by the raw material of following weight portion:

Caulis Kadsurae Coccineae 25-35 part, erythrina indica 25-35 part, Flos Ilicis Asprellae 25-35 part, Cortex Ilicis Rotundae 25-35 part, longan parasitic tea 25-35 part, parasitic 25-35 part set by Nashi Pear, the parasitic tea 25-35 part of water banyan wood, Millettia Speciosa 15-25 part, Radix Abelmoschi Sagittifolii 15-25 part, Rhizoma disporopsis pernyi 15-25 part, Semen livistonae chinensis 15-25 part, Semen Alpiniae Katsumadai 15-25 part, Clausena excavata Burm.f. 15-25 part, Pericarpium Citri Reticulatae 15-25 part, Herba Solani Lyrati 15-25 part, Herba Lobeliae Chinensis 8-15 part, Herba Scutellariae Barbatae 8-15 part, Herba Hedyotidis Diffusae 8-15 part, Herba Agrimoniae 8-15 part, Herba Pogostemonis 8-15 part, Herba Dendrobii 8-15 part,

Preferably, be prepared from by the raw material of following weight portion:

Caulis Kadsurae Coccineae 30 parts, erythrina indica 30 parts, Flos Ilicis Asprellae 30 parts, Cortex Ilicis Rotundae 30 parts, the parasitic tea 30 parts of longan, parasitic 30 parts of Nashi Pear tree, water banyan wood parasitic tea 30 parts, Millettia Speciosa 20 parts, Radix Abelmoschi Sagittifolii 20 parts, Rhizoma disporopsis pernyi 20 parts, Semen livistonae chinensis 20 parts, Semen Alpiniae Katsumadai 20 parts, Clausena excavata Burm.f. 20 parts, Pericarpium Citri Reticulatae 20 parts, Herba Solani Lyrati 20 parts, Herba Lobeliae Chinensis 10 parts, Herba Scutellariae Barbatae 10 parts, Herba Hedyotidis Diffusae 10 parts, Herba Agrimoniae 10 parts, Herba Pogostemonis 10 parts, Herba Dendrobii 10 parts.

Below crude drug source and the primary efficacy of Chinese medicine preparation of the present invention:

Caulis Kadsurae Coccineae: bright red southern five tastes Kadsura coccinea (Lem.) the A. C. Smith of Magnoliaceae Kadsura, is used as medicine with root or rattan.[nature and flavor] are pungent; Micro-hardship; Warm in nature.[function cures mainly] promoting the circulation of QI to relieve pain, dispelling, collateral-activating, dissipating blood stasis for subsidence of swelling.For taste-blindness rate, chronic gastritis, acute gastroenteritis, rheumatic arthritis, treating swelling and pain by traumatic injury, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain.

Erythrina indica: Latin literary fame Erythrina variegata Linn..The fallen leaves arbor of pulse family, Erythrina.Leaves, bark and tree root can be used as medicine.[nature and flavor with return through] are bitter, pungent, flat.Antiinflammatory, antipyretic, dispel the wind, dampness removing, pain relieving.There is antipyretic and effect that is diuresis.

Flos Ilicis Asprellae: Aquifoliaceae Holly Folium Mume Ilicis Purpureae Ilex asprella (Hook. et Arn .) Champ. ex Benth., be used as medicine with root, leaf.The whole year can adopt, and clean section is dried.Another name: select and claim star, ilex asprella, native Radix Glycyrrhizae, mountain Radix Mume, false Armeniaca mume Sieb., white point scale, TianXing wood, Ilex asprella (Hook. et Arn.) Champ. ex Benth., Radix Ilicis Asprellae tea, bitter prunus mume (sieb.) sieb.et zucc., mountain prunus mume (sieb.) sieb.et zucc., some gradations marked on the beam of steelyard, Folium Mume Ilicis Purpureae, native Radix Glycyrrhizae.[nature and flavor] are bitter, sweet, cool.[function with cure mainly] heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst.For flu, high hot excessive thirst, tonsillitis, pharyngolaryngitis, tracheitis, pertussis, enteritis, dysentery, infectious hepatitis, wild gill fungus, arsenic poisoning.For herbal tea primary raw material; Traumatic injury is controlled in leaf external, carbuncle furuncle and phyma poison.

Cortex Ilicis Rotundae: be the dry bark of holly plant Ilex rotunda Thunb. Ilex rotunda Thumb..Summer, Qiu Erji strip, and dry.[nature and flavor with return through] are bitter, cold.Return lung, stomach, large intestine, Liver Channel.[function with cure mainly] heat-clearing and toxic substances removing, dampness removing pain relieving.For heat-damp in summer heating, laryngopharynx swelling and pain, damp-heat dysentery, abdominal distention, rheumatic arthralgia, eczema, furuncle, traumatic injury.

Longan is parasitic: another name Arillus Longan tree is parasitic, and circle eye tree is parasitic, and first meat tree is parasitic.[nature and flavor with return through] mildly bitter flavor, puckery, property is put down.Enter the heart, liver, stomach warp.[function with cure mainly] tranquilizing by nourishing the heart, antiinflammatory, invigorates blood circulation, removing food stagnancy eliminating stagnation, and control fidgets due to deficiency and sleep, gastric abscess, the traumatic injury stasis of blood is amassed.

Nashi Pear tree is parasitic: another name pear tree is parasitic, and pear wood is parasitic.Meridian distribution of property and flavor: puckery is cool.Enter lung, stomach, Liver Channel.Function cures mainly: promoting the production of body fluid to quench thirst, removing heat-phlegm, nourishing the lung to arrest cough, lowering the adverse-rising QI to subdue asthma.Control dryness of the lung heat cough, asthma, metrorrhagia, cough expectorant holds blood under the arm.

Water banyan tree is parasitic: another name water father-in-law wood is parasitic, and wine father-in-law wood is parasitic, and Flos Cleistocalycis Operculati is parasitic.[nature and flavor with return through] are bitter, puckery, are slightly cold.Water banyan tree is parasitic: another name water father-in-law wood is parasitic, and wine father-in-law wood is parasitic, and Flos Cleistocalycis Operculati is parasitic.[nature and flavor with return through] are bitter, puckery, are slightly cold.Enter lung, large intestine channel.[function with cure mainly] eliminating summer-heat from the exterior, clearing heat and expelling damp, detoxicating and fighting cancer.Cure mainly summer-heat cold, hygropyretic dysentery, icterohepatitis, gastric cancer, hemorrhoid.

Millettia Speciosa: call pig's feet large bamboo hat with a conical crown and broad brim, Jin Zhonggen, Radix Millettiae Speciosae, hang upside down Jin Zhong, energetically potato.For pulse family pulse family Millettia plant, beautiful millettia Millettia specisoa Champ..Millettia Speciosa is used as medicine with root, and Main Ingredients and Appearance is protein, starchiness and alkaloid etc.[meridian distribution of property and flavor] is sweet, flat.Return lung, kidney channel.The lung moistening of [function cures mainly] tonify deficiency, strong muscle is active.For lumbar muscle strain, rheumatic arthritis, controls lung-heat, cough due to deficiency of the lung, pulmonary tuberculosis, chronic bronchitis, chronic hepatitis, seminal emission, leucorrhea.

Radix Abelmoschi Sagittifolii: having another name called Fructus Citri Sarcodactylis ginseng, Rhizoma Gymnadeniae, is the dry tuber of orchid Rhizoma Gymnadeniae.Warm in nature, profit, sweet in the mouth.Have and tonify Qi of the kidney, spermatogenesis lung moistening, consolidate effect of health preserving, strong human body.Can repercussive pain relieving, control traumatic injury, spleen reinforcing lung moistening, calm the nerves relieving convulsion, QI invigorating pain relieving, physical weakness, neurasthenia, impairment caused by overstrain, cough, asthma etc. can be cured.

Rhizoma disporopsis pernyi: be the rhizome of the false cantonese fairy bells of liliaceous plant sword-like leave.Disporopsis pernyi (Hua) Diels [Aulisconema pernyi Hua; Disporopsis arisanensis Hayata] [nature and flavor] sweet, flat.[function cures mainly] nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst, controls menoxenia, impairment caused by overstrain rheumatalgia, and void coughs many skewers, puerperal asthenia, polyuria at night or seminal emission lumbago.

Semen livistonae chinensis: be again flabellum certain herbaceous plants with big flowers, Livistona chinensis R.Br., the root of Palmae Livistona plant Semen livistonae chinensis Livistona chinensis (Jacq.) R. Br..[function cures mainly] pain relieving, treats various pain.[nature and flavor] sweet in the mouth; Puckery; Property is put down.

Semen Alpiniae Katsumadai: another name Hainan Alpinia japonica (Thunb.) Miq., Alpinia henryi, Fructus Alpinia Japanicae, false Fructus Amomi.Latin literary fame Alpinia hainanensis K. Schum. Zingiberaceae, Alpinia plants are the fruit of zingiberaceous plant shellflower.[function cures mainly] dry temperature cold relieving, expectorant preventing the attack (or recurrence) of malaria, spleen invigorating warming the stomach.Stagnant, dyspepsia, vomiting and diarrhoea is interrupted for trusted subordinate's cold type of pain, distension and fullness of the chest and abdomen, expectorant.Also often do flavoring agent use, have appetizing effect.

Clausena excavata Burm.f.: Rutaceae clausena plant Clausena excavata Burm.f. Clausena excavata Burm. f. [function cures mainly] is antipyretic, removing toxic substances, admittedly lung meridian, and being dispelling the wind and dampness pathogens, arthritis good medicine, can going miasma, control stomachache, is also one of antidote for snake bites of venom.

Pericarpium Citri Reticulatae: be the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Harvesting ripe fruit, strips peel, dries or cold drying.[nature and flavor with return through] are bitter, pungent, temperature.Return lung, spleen channel.[function with cure mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.

Herba Solani Lyrati: be Solanaceae activity of Solanum Lyratum Thunb Solanum lyratum Thunb. [S. dulcamara L. var. lyratum (Thunb.) Sieb. et Zucc., S. Dulcamara L. var. pubescens Blume, S.Dulcamara L. var. chinense Dunal], with all herbal medicine.Hardship, is slightly cold.Slightly poisonous.Enter liver, stomach warp.Heat-clearing and toxic substances removing, inducing diuresis and reducing edema, anticancer.For cold, fever, acute mastitis, malignant boil, jaundice due to damp-heat, ascites, leucorrhea, oedema due to nephritis; Carbuncle furuncle and phyma poison is controlled in external.

Herba Lobeliae Chinensis: be the dry herb of Campanulaceae Herba Lobeliae Chinensis Lobelia chinensis Lour..Pungent, flat.GUIXIN, small intestinal, lung meridian.Inducing diuresis to remove edema, heat-clearing and toxic substances removing.For extensive abdominal edema, face foot edema, carbuncle furuncle, snake bite and insect sting; Advanced schistosomiasis ascites.

Herba Scutellariae Barbatae: be the dry herb of labiate Herba Scutellariae Barbatae Scutellaria barbata Don [S. rivularis Wall].Pungent, bitter, cold.Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.

Herba Hedyotidis Diffusae: be the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.].Sweet, light, cool.Enter stomach, large intestine, small intestine meridian.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.

Herba Agrimoniae: be the dry aerial parts of rosaceous plant Radix Agrimoniae Agrimonia pilosa Ledeb..Bitter, puckery, flat.GUIXIN, Liver Channel.Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.

Herba Pogostemonis: formal name used at school: Agastache rugosa (Fisch. et Mey.) O. Ktze.; Have another name called: blending, grey announcement, mountain Fructus Foeniculi etc., belong to tubular flower order, Labiatae herbaceos perennial.[nature and flavor with return through] are pungent, tepor.Return spleen, stomach, lung meridian.[function with cure mainly] eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, uncomfortable in chestly do not relax, cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.

Herba Dendrobii: be orchid Dendrobium nobile Dendrobium nobile Lindl., Dendrobium chrysotoxum Dendrobium chrysotoxum Lindl. or the cultivation product of Dendrobium fimbriatum Hook. Dendrobium fimbriatum Hook. and the fresh or dry stem of congener allied species thereof.The whole year all can gather, and fresh user removes root and silt; After dry user gathers, removing impurity, slightly scald or softened by baking, then stranding limit, limit is baked with boiled water, rubs with the hands clean to sheath, dry.[nature and flavor with return through] are sweet, are slightly cold.Return stomach, kidney channel.[function with cure mainly] reinforcing stomach reg fluid, nourishing YIN and clearing away heat.For calentura Tianjin wound, xerostomia excessive thirst, deficiency of stomach-Yin, lack of appetite is retched, and deficiency-heat is not moved back after being ill, hyperactivity of fire caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, poor vision, and muscles and bones flaccidity is soft.

Another aspect of the present invention there is provided the preparation method of the active component of pharmaceutical composition of the present invention, and the method is the ethanol extraction adopting water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:

Scheme one: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains active component.

Scheme two: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.

Scheme three: get whole medical material, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 4-10 of medical material total amount doubly, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.

The pharmaceutical composition for the treatment of superficial gastritis of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, syrup etc.

Pharmaceutically acceptable carrier of the present invention includes but not limited to following:

Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.

Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.

Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.

Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.

Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.

Correctives: sucrose, monosaccharide, aromatic etc.

Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.

Spleen and stomach damp-heat type patient retention of damp-heat in the interior, heat clearing away easily helps wet, the easy heat-dissipating of damp eliminating, so treatment is got up more thorny, it is slower often to get effect.In the selection of medicine, the product selecting eliminating damp-heat should be noted, be cautious use of the medicine of fragrant dry damp eliminating and the agent of heavy dose of heat-clearing and toxic substances removing.

Caulis Kadsurae Coccineae energy promoting flow of QI and blood of the present invention, reducing swelling and alleviating pain; Erythrina indica anti-inflammatory analgetic; Flos Ilicis Asprellae heat-clearing and toxic substances removing, antiinflammatory; Cortex Ilicis Rotundae heat-clearing and toxic substances removing, dampness removing pain relieving; The parasitic tranquilizing by nourishing the heart of longan, antiinflammatory, invigorates blood circulation, removing food stagnancy eliminating stagnation; Parasitic removing heat-phlegm set by Nashi Pear; Water banyan sets parasitic clearing heat and expelling damp, detoxicating and fighting cancer; The lung moistening of Millettia Speciosa tonify deficiency, strong muscle is active; Radix Abelmoschi Sagittifolii is tonified Qi of the kidney, consolidate foster body; Rhizoma disporopsis pernyi nourishing YIN and moistening the lung; Semen livistonae chinensis astringing to arrest bleeding; Hidroschesis; The dry temperature cold relieving of Semen Alpiniae Katsumadai, expectorant preventing the attack (or recurrence) of malaria, spleen invigorating warming the stomach; Clausena excavata Burm.f. is antipyretic, removing toxic substances, admittedly lung meridian; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Herba Solani Lyrati: heat-clearing and toxic substances removing, inducing diuresis and reducing edema; Herba Lobeliae Chinensis inducing diuresis to remove edema; Herba Scutellariae Barbatae blood stasis dispelling diuresis; Herba Hedyotidis Diffusae inducing diuresis to remove edema, promoting blood circulation and stopping pain; Herba Agrimoniae astringing to arrest bleeding; Herba Pogostemonis eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting; Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Full side collocation is scientific and reasonable, meets System of Chinese medicine, mutually works in coordination with, such that Chinese medicine of the present invention has good clearing away heat and eliminating dampness, spleen invigorating is regulated the flow of vital energy, stomach function regulating blood stasis dispelling effect.

A kind of pharmaceutical composition for the treatment of superficial gastritis provided by the invention has the following advantages:

1, pharmaceutical composition provided by the invention can effectively treat damp-heat type superficial gastritis, and total effective rate is 95.0%, and therapeutic effect compared with prior art has significant difference (P<0.05).

The symptoms such as 2, pharmaceutical composition provided by the invention is when being used for the treatment of superficial gastritis, can significantly eliminate within a short period of time or slow down middle epigastric discomfort, middle upper abdomen dull pain, burning pain, glutted, inappetence, belch, pantothenic acid, nauseating, reduce patient suffering.

3, pharmaceutical composition preparation method of the present invention is simple, is applicable to basic medical unit or producer's production in enormous quantities.

Detailed description of the invention

The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1:

Get Caulis Kadsurae Coccineae 30g, erythrina indica 30g, Flos Ilicis Asprellae 30g, Cortex Ilicis Rotundae 30g, the parasitic tea 30g of longan, parasitic 30g set by Nashi Pear, the parasitic tea 30g of water banyan wood, Millettia Speciosa 20g, Radix Abelmoschi Sagittifolii 20g, Rhizoma disporopsis pernyi 20g, Semen livistonae chinensis 20g, Semen Alpiniae Katsumadai 20g, Clausena excavata Burm.f. 20g, Pericarpium Citri Reticulatae 20g, Herba Solani Lyrati 20g, Herba Lobeliae Chinensis 10g, Herba Scutellariae Barbatae 10g, Herba Hedyotidis Diffusae 10g, Herba Agrimoniae 10g, Herba Pogostemonis 10g, Herba Dendrobii 10g, extracting in water 2 times, twice amount of water is respectively 10 times of medical material gross weight, 8 times, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.

Embodiment 2:

Get Caulis Kadsurae Coccineae 25g, erythrina indica 25g, Flos Ilicis Asprellae 25g, Cortex Ilicis Rotundae 25g, the parasitic tea 25g of longan, parasitic 25g set by Nashi Pear, the parasitic tea 25g of water banyan wood, Millettia Speciosa 15g, Radix Abelmoschi Sagittifolii 15g, Rhizoma disporopsis pernyi 15g, Semen livistonae chinensis 15g, Semen Alpiniae Katsumadai 15g, Clausena excavata Burm.f. 15g, Pericarpium Citri Reticulatae 15g, Herba Solani Lyrati 15g, Herba Lobeliae Chinensis 8g, Herba Scutellariae Barbatae 8g, Herba Hedyotidis Diffusae 8g, Herba Agrimoniae 8g, Herba Pogostemonis 8g, Herba Dendrobii 8g, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times of medical material total amount, 8 times, 4 times, 3 hours respectively extraction time, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 60 DEG C, relative density is the extractum of 1.25, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.

Embodiment 3:

Get Caulis Kadsurae Coccineae 25g, erythrina indica 35g, Flos Ilicis Asprellae 25g, Cortex Ilicis Rotundae 35g, the parasitic tea 25g of longan, parasitic 35g set by Nashi Pear, the parasitic tea 25g of water banyan wood, Millettia Speciosa 15g, Radix Abelmoschi Sagittifolii 25g, Rhizoma disporopsis pernyi 15g, Semen livistonae chinensis 25g, Semen Alpiniae Katsumadai 15g, Clausena excavata Burm.f. 25g, Pericarpium Citri Reticulatae 15g, Herba Solani Lyrati 25g, Herba Lobeliae Chinensis 8g, Herba Scutellariae Barbatae 15g, Herba Hedyotidis Diffusae 8g, Herba Agrimoniae 15g, Herba Pogostemonis 8g, Herba Dendrobii 15g, extracting in water 3 times, three amount of water are equivalent to 12 times of medical material gross weight respectively, 8 times, 6 times, 3 hours respectively each extraction time, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, add ethanol, alcohol content is made to be 40%, leave standstill 24 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.10, add 3 times that purified water ad pond om is medical material gross weight, fill, obtain mixture of the present invention.

Embodiment 4:

Get Caulis Kadsurae Coccineae 35g, erythrina indica 25g, Flos Ilicis Asprellae 35g, Cortex Ilicis Rotundae 25g, the parasitic tea 35g of longan, parasitic 25g set by Nashi Pear, the parasitic tea 35g of water banyan wood, Millettia Speciosa 15g, Radix Abelmoschi Sagittifolii 25g, Rhizoma disporopsis pernyi 15g, Semen livistonae chinensis 25g, Semen Alpiniae Katsumadai 15g, Clausena excavata Burm.f. 25g, Pericarpium Citri Reticulatae 15g, Herba Solani Lyrati 25g, Herba Lobeliae Chinensis 8g, Herba Scutellariae Barbatae 15g, Herba Hedyotidis Diffusae 8g, Herba Agrimoniae 15g, Herba Pogostemonis 8g, Herba Dendrobii 15g, with alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times of medical material total amount, 8 times, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.

Embodiment 5:

Get Caulis Kadsurae Coccineae 30g, erythrina indica 25g, Flos Ilicis Asprellae 30g, Cortex Ilicis Rotundae 25g, the parasitic tea 30g of longan, parasitic 25g set by Nashi Pear, the parasitic tea 30g of water banyan wood, Millettia Speciosa 15g, Radix Abelmoschi Sagittifolii 20g, Rhizoma disporopsis pernyi 15g, Semen livistonae chinensis 20g, Semen Alpiniae Katsumadai 15g, Clausena excavata Burm.f. 20g, Pericarpium Citri Reticulatae 15g, Herba Solani Lyrati 20g, Herba Lobeliae Chinensis 10g, Herba Scutellariae Barbatae 8g, Herba Hedyotidis Diffusae 10g, Herba Agrimoniae 8g, Herba Pogostemonis 10g, Herba Dendrobii 8g, extracting in water 3 times, three amount of water are respectively 12 times of medical material gross weight, 8 times, 6 times, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, obtained capsule.

Embodiment 6:

Get Caulis Kadsurae Coccineae 35g, erythrina indica 35g, Flos Ilicis Asprellae 35g, Cortex Ilicis Rotundae 35g, the parasitic tea 35g of longan, parasitic 35g set by Nashi Pear, the parasitic tea 35g of water banyan wood, Millettia Speciosa 25g, Radix Abelmoschi Sagittifolii 25g, Rhizoma disporopsis pernyi 25g, Semen livistonae chinensis 25g, Semen Alpiniae Katsumadai 25g, Clausena excavata Burm.f. 25g, Pericarpium Citri Reticulatae 25g, Herba Solani Lyrati 25g, Herba Lobeliae Chinensis 15g, Herba Scutellariae Barbatae 15g, Herba Hedyotidis Diffusae 15g, Herba Agrimoniae 15g, Herba Pogostemonis 15g, Herba Dendrobii 15g, extracting in water 2 times, each amount of water is equivalent to 12 times of medical material gross weight respectively, 10 times, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, add ethanol, alcohol content is made to be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, add adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule.

Embodiment 7:

Take Caulis Kadsurae Coccineae 30g, erythrina indica 30g, Flos Ilicis Asprellae 30g, Cortex Ilicis Rotundae 30g, the parasitic tea 30g of longan, Nashi Pear set parasitic 30g, water banyan wood parasitic tea 30g, Millettia Speciosa 20g, Radix Abelmoschi Sagittifolii 20g, Rhizoma disporopsis pernyi 20g, Semen livistonae chinensis 20g, Semen Alpiniae Katsumadai 20g, Clausena excavata Burm.f. 20g, Pericarpium Citri Reticulatae 20g, Herba Solani Lyrati 20g, Herba Lobeliae Chinensis 10g, Herba Scutellariae Barbatae 10g, Herba Hedyotidis Diffusae 10g, Herba Agrimoniae 10g, Herba Pogostemonis 10g, Herba Dendrobii 10g, clean, dry, pulverizing, obtains powder of the present invention.

Clinical treatment is summed up

1 clinical data

1.1 physical data enter the routine patient of group 80, and be all diagnosed as chronic superficial gastritis through electronic gastroscope and pathologic finding, Chinese medical discrimination is syndrome of dampness-heat of spleen and stomach.

Be divided into 2 groups at random, often organize each 40 examples, treatment group man 32 example, female 18 example; Age 22-55 year, 38 years old; Course of disease 0.5-6.Matched group man 34 example, female 16 example; Age 20-54 year, 37 years old; Course of disease 0.5-6.The aspects such as two groups of sexes, age, the course of disease, clinical syndrome integral, gastric mucosal erosion through statistical procedures, difference there are no significant meaning (P>0.05).

1.2 Western medicine diagnose standards formulate diagnostic criteria with reference to " combination of Chinese and Western medicine diagnosis and treatment project (draft) of chronic gastritis ": (1) has middle epigastric discomfort, middle upper abdomen dull pain, and burning pain is glutted, without obvious rhythmicity, heavier after general feed; The symptoms such as next has inappetence, belch, pantothenic acid, nauseating.(2) gastroscope and pathological criteria is met.

1.3 tcm diagnosis standards are with reference to syndrome of dampness-heat of spleen and stomach standard in " new Chinese medicine guideline of clinical investigations (trying) " and " combination of Chinese and Western medicine diagnosis and treatment project (draft) of chronic gastritis ": main syndromes: (1) gastral cavilty is scorching hot, distending pain (2) bitter taste halitosis or xerostomia (3) gastral cavity abdomen painful abdominal mass vexed, thirst but no desire to drink (4) red tongue, limit point is dark red, yellow fur is thick or greasy, slippery and rapid pulse or moisten number.

2 Therapeutic Method

Treatment group: give the embodiment of the present invention 1 syrup, each 30ml, every day 2 times.

Matched group: rabeprazole enteric coated capsule, hydrotalcite tablet, domperidone tablet, the treatments such as Fosfalugel (Yamanouchi), by different symptoms, independent or cooperation administration, all gives routine dose.

All treat after 2 weeks for two groups and carry out efficacy determination and contrast.Treatments period, all requires to avoid pungent greasy food, ban on opium-smoking and the opium trade wine.

3 efficacy evaluations and statistical method

3.1 clinical therapeutic effect of syndrome are drafted with reference to " gastrointestinal disease TCM syndrome evaluation table ": asymptomatic is 0 point; Symptom is comparatively light, does not affect routine work and life is 3 points; Symptom is obvious, and some effects routine work and life are 5 points; Serious symptom, obviously affects routine work and life, and needing Drug therapy to alleviate is 7 points.Syndrome integral sum × 100% before curative effect scoring=(before treating, after syndrome integral sum-treatment, syndrome integral is total)/treatment.

Clinical recovery: syndrome disappears substantially, reduces and reaches more than 95%;

Effective: syndrome comparatively treats front improvement, reduce and reach 76-95%;

Effective: syndrome comparatively treats front improvement, reduce and reach 50-75%;

Invalid: syndrome without improvement, or is improved not obvious, reduce only less than 50%.

3.2 statistical methods adopt SPSS to carry out statistical analysis, enumeration data X 2 test.

The clinical therapeutic effect of syndrome of 4 result two groups is in table 1.

The table 1 liang clinical therapeutic effect of syndrome of group compares

Group	Number of cases	Clinical recovery	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	40	26	6	6	2	95.0 ^*
Matched group	40	21	4	6	9	77.5

Note: compare with matched group, * P<0.05

After two groups of patient treatments, clinical syndrome all has clear improvement, but the total effective rate for the treatment of group compares with matched group, and difference is very significant (P<0.05), points out that pharmaceutical composition effect of the present invention is excellent existing western medicine technology.Clinical recovery patient, follows up a case by regular visits in year in tracking, has no recurrence.

5 discuss

The treatment of current doctor trained in Western medicine to chronic gastritis is confined to eradicate on Hp and symptomatic treatment more, but increasing clinical practice shows, eradicates Hp merely, can not solve the slight illness of numerous patients completely.The applicant, according to a large amount of clinical experience for the treatment of this disease for many years, sums up pharmaceutical composition of the present invention, and when treating damp-heat type superficial gastritis, onset is rapid, evident in efficacy, and prognosis is not easily recurred, and eradicates effect more satisfactory.

Interpretation of result: treatment group of the present invention and matched group all have good curative effect treating damp-heat type superficial gastritis, but treatment group compares with matched group significant difference, total effective rate of the present invention is more excellent compared with matched group, has significant difference (P<0.05).It can thus be appreciated that medicine composite for curing damp-heat type superficial gastritis Be very effective of the present invention is better than prior art.

Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims

1. treat the pharmaceutical composition of superficial gastritis, it is characterized in that it is prepared from by the raw material of following weight portion: Caulis Kadsurae Coccineae 25-35 part, erythrina indica 25-35 part, Flos Ilicis Asprellae 25-35 part, Cortex Ilicis Rotundae 25-35 part, longan parasitic tea 25-35 part, parasitic 25-35 part set by Nashi Pear, the parasitic tea 25-35 part of water banyan wood, Millettia Speciosa 15-25 part, Radix Abelmoschi Sagittifolii 15-25 part, Rhizoma disporopsis pernyi 15-25 part, Semen livistonae chinensis 15-25 part, Semen Alpiniae Katsumadai 15-25 part, Clausena excavata Burm.f. 15-25 part, Pericarpium Citri Reticulatae 15-25 part, Herba Solani Lyrati 15-25 part, Herba Lobeliae Chinensis 8-15 part, Herba Scutellariae Barbatae 8-15 part, Herba Hedyotidis Diffusae 8-15 part, Herba Agrimoniae 8-15 part, Herba Pogostemonis 8-15 part, Herba Dendrobii 8-15 part.

2. pharmaceutical composition according to claim 1, is characterized in that it is prepared from by the raw material of following weight portion: Caulis Kadsurae Coccineae 30 parts, erythrina indica 30 parts, Flos Ilicis Asprellae 30 parts, Cortex Ilicis Rotundae 30 parts, the parasitic tea 30 parts of longan, parasitic 30 parts of Nashi Pear tree, water banyan wood parasitic tea 30 parts, Millettia Speciosa 20 parts, Radix Abelmoschi Sagittifolii 20 parts, Rhizoma disporopsis pernyi 20 parts, Semen livistonae chinensis 20 parts, Semen Alpiniae Katsumadai 20 parts, Clausena excavata Burm.f. 20 parts, Pericarpium Citri Reticulatae 20 parts, Herba Solani Lyrati 20 parts, Herba Lobeliae Chinensis 10 parts, Herba Scutellariae Barbatae 10 parts, Herba Hedyotidis Diffusae 10 parts, Herba Agrimoniae 10 parts, Herba Pogostemonis 10 parts, Herba Dendrobii 10 parts.

3. pharmaceutical composition as claimed in claim 1 or 2, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.

4. pharmaceutical composition as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains described active component.

5. pharmaceutical composition as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, adds ethanol, makes alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.

6. pharmaceutical composition as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, with 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.

7. treat the pharmaceutical composition of superficial gastritis, prepared into acceptable carrier in pharmaceuticals industry by the pharmaceutical composition for the treatment of superficial gastritis described in claim 1 or 2.