CN101579507B

CN101579507B - Medicine for treating gall stones and preparation method thereof

Info

Publication number: CN101579507B
Application number: CN2009100740170A
Authority: CN
Inventors: 路正平
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-03-23
Filing date: 2009-03-23
Publication date: 2011-06-15
Anticipated expiration: 2029-03-23
Also published as: CN101579507A

Abstract

A medicine for treating gall stones is prepared by the following steps: processed pangolin, leech, earthworm, corydalis tuber and semen plantaginis are mixed with spora lygodii, desmodium, salvia miltiorrhiza, red paeony root, white paeony root, radix curcumae, costus root, radix scutellariae, radix isatidis, green rangerine peel, dried orange peel and liquorice; then water is added for decoctingthe mixture, and decocted liquid is filtered to be concentrated into extract; at last, the extract is dried and pulverized to be put into capsules, so that the medicine of the invention is obtained. The medicine of the invention has the efficacies of clearing heat, promoting diuresis, and removing retention and gall stones; the medicine of the invention is used for treating gall stones, and can bring the effect that gall stones gradually become small so as to be expelled out of bodies. Through clinical observation, the total effective rate of the medicine is 90.0%.

Description

A kind of medicine for the treatment of cholelithiasis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of calculus, particularly relating to a kind of is the medicine of the treatment cholelithiasis of feedstock production with Chinese medicine.The invention still further relates to the preparation method of this medicine.

Background technology

Biliary Calculi disease is meant that biliary system comprises that the disease of calculus takes place at any position of gallbladder and bile duct.Cholelithiasis is divided into cholelithiasis, choledocholithiasis and calculus of intrahepatic duct by the position, be divided into cholesterol calculus, bile pigment calculus (comprising melanin calculus and brown pigment calculus) and mixed calculus by composition, the branch of infectious calculus, metabolic calculus, retention calculus, mixed calculus is then arranged by the cause of disease.Although the pathogenesis of heterogeneity calculus is different with predilection site, its Clinical symptoms is similar.80% cholelithiasis patient is the silence calculus, can not have seizure of disease all the life.But the author that sends out that biliary colic was arranged had 75% case to show effect once more in 2 years, and the sickness rate of annual severe complication (cholecystitis, cholangitis, the property pancreatitis of gallbladder source, gallstone intestinal obstruction, gallbladder, common bile duct fistula, carcinoma of gallbladder) is 1～2%.

Mainly be operative therapy to Iithiasic treatment at present, its shortcoming is to cause very big misery to patient, and the high and easily recurrence of expense has wound in various degree even can cause a lot of sequela patient simultaneously.The normal calculus medicine that uses has danshitong capsules, lithagogue infusion and uralyt, its shortcoming be Time of Administration long, absorb slowly and don't lasting, particularly also be subjected to the restriction of stone location, size, what and composition.Chinese medicine calculus not only toxic and side effects is little, and drug effect is remarkable.The advantage and the characteristic of performance Chinese medicine, Iithiasic Chinese medicine medicine is treated in further investigation and exploitation, can improve patient's quality of life, for extensive patients brings glad tidings, has the wide development prospect.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of cholelithiasis, this medicine has clearing away heat-damp and promoting diuresis, removing food stagnancy calculi dissolving effect, is used for the treatment of cholelithiasis, can make maximum sizeization little, and progressively excrete.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Spora Lygodii 10～25 Herba Lysimachiaes 10～25

Squama Manis 3～8 Hirudos 2～5

Pheretima 5～10 Rhizoma Corydalis 8～18

Radix Salviae Miltiorrhizae 8～25 Radix Paeoniae Rubra 8～18

The Radix Paeoniae Alba 10～25 Radix Curcumaes 8～15

Radix Aucklandiae (Radix Vladimiriae) 8～13 Radix Scutellariaes 8～13

Radix Isatidis 8～13 Semen Plantaginiss 13～25

Pericarpium Citri Reticulatae Viride 8～13 Pericarpium Citri Reticulataes 8～13

Radix Glycyrrhizae 2～3.

Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.

The concrete preparation method of medicine of the present invention being made capsule is:

Squama Manis is fried to golden yellow in the sand that scalds heat, soaked drying with vinegar slightly; Hirudo is fried to little yellow airing after the spray vinegar in the Pulvis Talci that scalds heat; Pheretima is fried to little yellow airing after the spray vinegar; Rhizoma Corydalis is fried to little yellow airing after the spray vinegar; Semen Plantaginis is fried to the little Huang of explosion, airing.

The Squama Manis, Hirudo, Pheretima, Rhizoma Corydalis, the Semen Plantaginis that cook are mixed with Spora Lygodii, Herba Lysimachiae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Curcumae, Radix Aucklandiae (Radix Vladimiriae), Radix Scutellariae, Radix Isatidis, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, decoct with water 2～4 times, each 1～2 hour, collecting decoction filters, and being condensed into relative density is the clear paste of 1.15～1.18 (65～70 ℃), after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, sterilization is made capsule in incapsulating.

Calculus belongs to categories such as " hypochondriac pain ", " yellow cellulitis " in motherland's medical science, eating and drinking without temperance, disorder of emotion, cold temperature is uncomfortable, surfeit is greasy or malnutrition due to parasitic infestation etc. all can cause the formation of calculus, and clearing away heat-damp and promoting diuresis, removing food stagnancy fossil are answered in treatment.In the prescription of the present invention, Squama Manis, Hirudo promoting blood circulation and detumescence; Herba Lysimachiae, Spora Lygodii, the Endothelium Corneum Gigeriae Galli calculus heavily fortified point that disappears; The Radix Curcumae regulating QI to relieve pain; Pheretima heat clearing away, collateral dredging, diuresis; Rhizoma Corydalis promoting blood circulation to remove blood stasis, promoting the circulation of QI pain relieving; Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Paeoniae Alba stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire; Radix Aucklandiae (Radix Vladimiriae) promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach; Radix Scutellariae, Radix Isatidis heat clearing and damp drying, eliminating fire and detoxication, hemostasis; The Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria; The soothing the liver dispelling the stagnated QI of Pericarpium Citri Reticulatae Viride, removing food stagnancyization stagnate; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, and clearing away heat-damp and promoting diuresis, removing food stagnancy fossil are used for the treatment of cholelithiasis, can make calculus little by bigization, get rid of external.

Pharmaceutical dosage form of the present invention is a capsule, and the patient is easy to take, and takes safety, has overcome the shortcoming that traditional western medical treatment wound is big, subject range is little, has reduced the patient suffering, is more suitable for using in old, incompatibility operator.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 120 routine cholelithiasis patients that the curative effect of medicine of the present invention has been carried out clinical observation.

120 routine cases are divided into two groups at random, every group 60 example.Male 26 examples in the matched group, women 34 examples; Cholelithiasis 28 examples wherein, choledocholith 22 examples, hepatolith 10 examples.Male 28 examples in the treatment group, women 32 examples; Cholelithiasis 28 examples wherein, choledocholith 22 examples, hepatolith 10 examples.All cases are all diagnosed with reference to the diagnostic criteria of cholelithiasis in " new Chinese medicine clinical research guideline ".

The oral proglumide 400mg of matched group, vitamin K3 4mg, the concurrent infection person takes the circumstances into consideration to use antibiotic.The treatment group adopts medicine of the present invention to treat.2 weeks were 1 course of treatment, took 2 courses of treatment altogether.

Criterion of therapeutical effect is drafted with reference to " clinical disease diagnosis standard ".Recovery from illness: after medication 1～2 course of treatment, clinical symptoms, sign all disappear, and the ultrasound diagnosis calculus disappears.Produce effects: after medication 1～2 course of treatment, clinical symptoms, sign obviously alleviate, and the ultrasound diagnosis calculus reduces more than 50%.Effectively: after medication 1～2 course of treatment, clinical symptoms, sign alleviate, and the ultrasound diagnosis calculus reduces below 50%.Invalid: after medication 1～2 course of treatment, clinical symptoms, sign do not have obvious improvement, and the ultrasound diagnosis calculus does not have significant change.

Curative effect comparative result after two groups of cases are treated sees Table 1.

Curative effect after the table 1 liang group case treatment relatively

The specific embodiment

Embodiment 1

Get Squama Manis 100g and put into the sand that scalds heat and fry to being golden yellow, fully be puffed to shortcake and easily take out during porphyrize, spraying into vinegar while hot soaks slightly, pulls drying for standby out; Take out when Hirudo 60g is put into the extremely little yellow of Pulvis Talci stir-fry of scalding heat, then sprayed with vinegar, airing takes the dish out of the pot; 200g puts into marmite with Pheretima, fries to little yellow, sprays with vinegar, and airing takes the dish out of the pot; 200g puts into marmite with Rhizoma Corydalis, fries to little yellow, then sprays with vinegar, and airing takes the dish out of the pot; Airing when frying to the little Huang of explosion with marmite Semen Plantaginis 300g.

The above-mentioned Squama Manis that cooks, Hirudo, Pheretima, Rhizoma Corydalis, Semen Plantaginis are mixed with Spora Lygodii 300g, Herba Lysimachiae 300g, Radix Salviae Miltiorrhizae 300g, Radix Paeoniae Rubra 200g, Radix Paeoniae Alba 300g, Radix Curcumae 200g, Radix Aucklandiae (Radix Vladimiriae) 200g, Radix Scutellariae 200g, Radix Isatidis 200g, Pericarpium Citri Reticulatae Viride 200g, Pericarpium Citri Reticulatae 200g, Radix Glycyrrhizae 50g, decoct with water 3 times, each 1 hour, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.15 (70 ℃), after 50 ℃ of dryings, be ground into 120 purpose medicated powder, capsule is made in sterilization.

Embodiment 2

Get Squama Manis 80g and put into the sand that scalds heat and fry to being golden yellow, fully be puffed to shortcake and easily take out during porphyrize, spraying into vinegar while hot soaks slightly, pulls drying for standby out; Take out when Hirudo 50g is put into the extremely little yellow of Pulvis Talci stir-fry of scalding heat, then sprayed with vinegar, airing takes the dish out of the pot; 100g puts into marmite with Pheretima, fries to little yellow, sprays with vinegar, and airing takes the dish out of the pot; 180g puts into marmite with Rhizoma Corydalis, fries to little yellow, then sprays with vinegar, and airing takes the dish out of the pot; Airing when frying to the little Huang of explosion with marmite Semen Plantaginis 250g.

The above-mentioned Squama Manis that cooks, Hirudo, Pheretima, Rhizoma Corydalis, Semen Plantaginis are mixed with Spora Lygodii 250g, Herba Lysimachiae 250g, Radix Salviae Miltiorrhizae 250g, Radix Paeoniae Rubra 180g, Radix Paeoniae Alba 250g, Radix Curcumae 180g, Radix Aucklandiae (Radix Vladimiriae) 130g, Radix Scutellariae 130g, Radix Isatidis 130g, Pericarpium Citri Reticulatae Viride 130g, Pericarpium Citri Reticulatae 130g, Radix Glycyrrhizae 30g, decoct with water 3 times, each 2 hours, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.18 (70 ℃), after 50 ℃ of dryings, be ground into 120 purpose medicated powder, capsule is made in sterilization.

Claims

1. medicine for the treatment of cholelithiasis is to be crude drug by following parts by weight of traditional Chinese medicines:

Spora Lygodii 10～25 Herba Lysimachiaes 10～25

Squama Manis 3～8 Hirudos 2～5

Pheretima 5～10 Rhizoma Corydalis 8～18

Radix Salviae Miltiorrhizae 8～25 Radix Paeoniae Rubra 8～18

The Radix Paeoniae Alba 10～25 Radix Curcumaes 8～15

Radix Aucklandiae (Radix Vladimiriae) 8～13 Radix Scutellariaes 8～13

Radix Isatidis 8～13 Semen Plantaginiss 13～25

Radix Glycyrrhizae 2～3

Squama Manis is fried to golden yellow in the sand that scalds heat, soaked drying with vinegar slightly; Hirudo is fried to little yellow airing after the spray vinegar in the Pulvis Talci that scalds heat; Pheretima is fried to little yellow airing after the spray vinegar; Rhizoma Corydalis is fried to little yellow airing after the spray vinegar; Semen Plantaginis is fried to the little Huang of explosion, airing;

The Squama Manis, Hirudo, Pheretima, Rhizoma Corydalis, the Semen Plantaginis that cook are mixed with Spora Lygodii, Herba Lysimachiae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Curcumae, Radix Aucklandiae (Radix Vladimiriae), Radix Scutellariae, Radix Isatidis, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, decoct with water 2～4 times, each 1～2 hour, collecting decoction filters, and is condensed into 65～70 ℃ of relative densities and is 1.15～1.18 clear paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, sterilization is made capsule in incapsulating.