CN106581468A - Preparation method of traditional Chinese medicine capable of treating gastric ulcer - Google Patents

Preparation method of traditional Chinese medicine capable of treating gastric ulcer Download PDF

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CN106581468A
CN106581468A CN201610975012.5A CN201610975012A CN106581468A CN 106581468 A CN106581468 A CN 106581468A CN 201610975012 A CN201610975012 A CN 201610975012A CN 106581468 A CN106581468 A CN 106581468A
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parts
medicine
gastric ulcer
decoction
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姜迪蛟
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Chengdu Ling Xi Luxuries Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965Asparagus, e.g. garden asparagus or asparagus fern
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a preparation method of a traditional Chinese medicine capable of treating gastric ulcer. The method comprises the following steps that the traditional Chinese medicine is prepared from, by weight, 12-16 parts of fructus aurantii, 12-20 parts of sandalwood, 15-19 parts of white atractylodes rhizomes, 10-12 parts of asparagus cochinchinensis, 10-15 parts of pinellia ternata, 10-16 parts of rough melic herb, 6-12 parts of elecampane, 6-10 parts of cloves, 12-16 parts of Chinese yams, 10-18 parts of medicinal cyathula roots, 12-16 parts of myrrh and 8-14 parts of rhizoma picrorhizae. All traditional Chinese bulk pharmaceutical chemicals are soaked with clean water or purified water; the soaked traditional Chinese bulk pharmaceutical chemicals and liquid medicine obtained after soaking of the traditional Chinese bulk pharmaceutical chemicals are added into a medicine boiling container, a lid is added for joint decoction; after decoction is completed, liquid medicine is filtered out, and the obtained liquid medicine is used for oral administration. The method has the advantages that on the basis of cognition of the gastric ulcer symptom mechanism and treatment principle, the direct oral administration method is adopted, tonification and purgation in combination are achieved, and the effects of tonifying the spleen and the stomach, promoting blood circulation to remove blood stasis, tonifying qi and nourishing the stomach are achieved, the quality is easy to control, the stability is good, and no adverse reaction exists basically.

Description

A kind of Chinese medicinal preparation method that can treat gastric ulcer
Technical field
The present invention relates to the field of Chinese medicines, is a kind of Chinese medicinal preparation method that can treat gastric ulcer specifically.
Background technology
Gastric ulcer is a kind of clinical most commonly seen digestive system disease, and patient is mainly shown as that epigastrium is chronic, rule Property pain.The generation of gastric ulcer and heredity, life(Long-term alcohol or to take nonsteroidal antiinflammatory drug, diet irregular), spirit Factor(Psychentonia, anxiety)Relevant, in recent years, research shows, helicobacter pylori infections are that the important of gastric ulcer generation is caused a disease Reason, therefore, when gastric ulcer is treated, Helicobacter pylori Infection is also key.Gastric ulcer easily recurs, and the course of disease is long, to trouble The quality of life of person causes serious impact.And easily there are various complication, such as gastric perforation, gastric cancer in gastric ulcer PD Deng.With the quickening of people's rhythm of life, people's chronic dietary is irregular, psychentonia, overworked, causes gastric ulcer Sickness rate rises year by year, it has also become one of important diseases of serious harm human health.
According to the pathogenic factor and characteristics of incidence of gastric ulcer, the key agents of the western medical treatment of current gastric ulcer are including antiacid Agent(Sodium bicarbonate, sodium hydroxide), proton pump inhibitor(Omeprazole, lansoprazole etc.), H2 receptor blocking agent(Sago is replaced Fourth, ranitidine, Famotidine etc.), gastric mucosa protective agent(Misoprostol etc.), anti-helicobacter pylori class medicine(Metronidazole Deng), but western medical treatment has therapeutic effect undesirable, large side effects, the shortcoming for easily recurring.The traditional Chinese medical science thinks, Mechanism of Gastric Ulcer Basic factor is weakness of the spleen and stomach, and the important pathology link of morbidity is stagnant heat, shows as simulataneous insufficiency and excessive, cold and heat patients w ith peptic ulcer disease wrong more It is miscellaneous.In recent years, for the Chinese traditional treatment of gastric ulcer also gradually causes the concern and attention of people, also occur in that on market more The Chinese medicine preparation for the treatment of gastric ulcer, the such as Radix Astragali build middle ball, Chaihushugan Pill, WEIDE peace capsule, but these Chinese medicine ingredients are complicated, Patient can cause untoward reaction after long-term taking, still.
The content of the invention
It is an object of the invention to provide a kind of evident in efficacy, instant effect, can treating in gastric ulcer of having no side effect Medicament preparation.
The present invention is achieved through the following technical solutions:A kind of Chinese medicinal preparation method that can treat gastric ulcer, including it is following Several steps:
Step S1:In parts by weight, weigh 12 ~ 16 parts of Fructus Aurantii, 12 ~ 20 parts of Lignum Santali Albi, 15 ~ 19 parts of the Rhizoma Atractylodis Macrocephalae, 10 ~ 12 parts of Radix Asparagi, half 10 ~ 15 parts of summer, 10 ~ 16 parts of Herba Melicae Scabrosae, 6 ~ 12 parts of the Radix Aucklandiae, 6 ~ 10 parts of Flos Caryophylli, 12 ~ 16 parts of Rhizoma Dioscoreae, 10 ~ 18 parts of Radix Cyathulae, Myrrha 12 ~ 16 parts, 8 ~ 14 parts of Rhizoma Acori Calami, 10 ~ 16 parts of Lignum Santali Albi;
Step S2:By above-mentioned whole raw material of Chinese medicine medicines, to be soaked 30 minutes with clear water or pure water in advance, water consumption for immersion is 0.9 ~ 1.1L;
Step S3:The liquid medicine of the raw material of Chinese medicine medicine after immersion and its immersion is added in decocting container, is added a cover and is decocted jointly;
Step S4:First make decocting container herb liquid seethe with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 need to be stirred when boiling medicine ~ 3 times;
Step S5:After the completion of decoction, medicinal liquid is leached, obtain medicinal liquid and be endo-medicine.
Described step S3 includes following step:
Step S301:First Fructus Aurantii, Lignum Santali Albi, the Rhizoma Atractylodis Macrocephalae, Radix Asparagi are added in decocting container and are decocted 10 minutes with small fire;
Step S302:The Rhizoma Pinelliae, Herba Melicae Scabrosae, the Radix Aucklandiae, Flos Caryophylli are added in decocting container are again decocted 10 minutes with small fire;
Step S303:Rhizoma Dioscoreae, Radix Cyathulae, Myrrha, Rhizoma Acori Calami are added in decocting container again.
Described step S2 ~ S5 is decoction for the first time, also including step S6:
Second decoction is carried out using 0.7 ~ 0.8L clear water or pure water repeat step S3 ~ S5;
Third time decoction is carried out using 0.5 ~ 0.6L clear water or pure water repeat step S3 ~ S5.
Described first time decocts and carries out two hours, and second decoction is carried out one hour, and third time is decocted and carries out one hour.
Described decocting container is marmite, enamel ware or rustless steel, avoids and uses ironware.
A kind of crude drug pharmacology of Chinese medicine formula that can treat gastric ulcer of the present invention:
Fructus Aurantii:It is warm in nature, bitter in the mouth, pungent, acid.Returns spleen Jing, stomach.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Category QI regulating medicine.
Lignum Santali Albi:It is warm in nature, acrid in the mouth.Return lung Jing, stomach, spleen channel, heart channel.Circulation of qi promoting warming middle-JIAO, appetizing pain relieving.Category QI regulating medicine.
The Rhizoma Atractylodis Macrocephalae:It is warm in nature, sweet in the mouth, hardship.Returns spleen Jing, stomach.It is spleen invigorating, QI invigorating, eliminate dampness and have diuretic effect, hidroschesis, antiabortive.Under category qi-restoratives medicine The Qi-tonifying drug of category classification.
Radix Asparagi:It is cold in nature, sweet in the mouth, hardship.Return lung Jing, kidney channel.Nourishing YIN to relieve dryness, the lung moistening and production of body fluid promoting.The benefit of category qi-restoratives medicine subordinate's classification Cloudy medicine.
The Rhizoma Pinelliae:Warm in nature, acrid in the mouth is poisonous.Returns spleen Jing, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Category is clear The heat clearing and dampness removing medicine of medicine of a warm nature subordinate classification.
Herba Melicae Scabrosae:It is cool in nature, sweet in the mouth.Return through without.Heat clearing away, expelling summer-heat, diuresis.The inducing diuresis to remove edema of category damp-clearing drug subordinate's classification Medicine.
The Radix Aucklandiae:It is warm in nature, acrid in the mouth, hardship.Returns spleen Jing, stomach, large intestine channel, tri-jiao channel, gallbladder meridian.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Category QI regulating medicine.
Flos Caryophylli:Acrid in the mouth, it is warm in nature.Return stomach, spleen channel, kidney channel.Warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.Category drugs for dispelling internal cold.
Rhizoma Dioscoreae:It is mild-natured, sweet in the mouth.Returns spleen Jing, lung meridian, kidney channel.Spleen reinforcing nourishing the stomach, engender liquid and benefic lung, the kidney invigorating arresting seminal emission.Under category qi-restoratives medicine The Qi-tonifying drug of category classification.
Radix Cyathulae:It is mild-natured, sweet in the mouth, slight bitter.Return liver warp, kidney channel.Eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.Category promoting blood circulationization The blood-activating and menstruation-regulating medicinal of stasis of blood medicine subordinate classification.
Myrrha:It is mild-natured, acrid in the mouth, hardship.Thoughts of returning home warp, Liver Channel, spleen channel.Scattered stasis pain, detumescence and promoting granulation.Lower point of drug for invigorating blood circulation and eliminating stasis of category The blood-activating analgesic of class.
Rhizoma Acori Calami:It is warm in nature, it is bitter in the mouth, pungent.Thoughts of returning home warp, Liver Channel, stomach.Stomach warming, anti-inflammatory analgetic.Category digestantss.
The present invention compared with prior art, with advantages below and beneficial effect:
The present invention is to be based on understanding and the Therapeutic Principle to gastric ulcer symptom mechanism, the directly oral method of employing, reinforcement and elimination in combination, With strong taste, blood circulation promoting and blood stasis dispelling, QI invigorating nourishing the stomach effect, evident in efficacy, quality is easily controlled, good stability, substantially invariably Good reaction.
Specific embodiment
The present invention is described in further detail with reference to embodiment, but embodiments of the present invention not limited to this.
Embodiment 1:
A kind of Chinese medicine formula that can treat gastric ulcer, including 12 ~ 16 parts of Fructus Aurantii by weight, 12 ~ 20 parts of Lignum Santali Albi, the Rhizoma Atractylodis Macrocephalae 15 ~ 19 parts, 10 ~ 12 parts of Radix Asparagi, 10 ~ 15 parts of the Rhizoma Pinelliae, 10 ~ 16 parts of Herba Melicae Scabrosae, 6 ~ 12 parts of the Radix Aucklandiae, 6 ~ 10 parts of Flos Caryophylli, Rhizoma Dioscoreae 12 ~ 16 Part, 10 ~ 18 parts of Radix Cyathulae, 12 ~ 16 parts of Myrrha, 8 ~ 14 parts of Rhizoma Acori Calami.
The method of the present embodiment medicine preparation, including following step:
Step S1:In parts by weight, weigh 12 ~ 16 parts of Fructus Aurantii, 12 ~ 20 parts of Lignum Santali Albi, 15 ~ 19 parts of the Rhizoma Atractylodis Macrocephalae, 10 ~ 12 parts of Radix Asparagi, half 10 ~ 15 parts of summer, 10 ~ 16 parts of Herba Melicae Scabrosae, 6 ~ 12 parts of the Radix Aucklandiae, 6 ~ 10 parts of Flos Caryophylli, 12 ~ 16 parts of Rhizoma Dioscoreae, 10 ~ 18 parts of Radix Cyathulae, Myrrha 12 ~ 16 parts, 8 ~ 14 parts of Rhizoma Acori Calami, 10 ~ 16 parts of Lignum Santali Albi;
Step S2:By above-mentioned whole raw material of Chinese medicine medicines, to be soaked 30 minutes with clear water or pure water in advance, water consumption for immersion is 0.9 ~ 1.1L;
Step S3:The liquid medicine of the raw material of Chinese medicine medicine after immersion and its immersion is added in decocting container, is added a cover and is decocted jointly Two hours, dosing included following step:
Step S301:First Fructus Aurantii, Lignum Santali Albi, the Rhizoma Atractylodis Macrocephalae, Radix Asparagi are added in decocting container and are decocted 10 minutes with small fire;
Step S302:The Rhizoma Pinelliae, Herba Melicae Scabrosae, the Radix Aucklandiae, Flos Caryophylli are added in decocting container are again decocted 10 minutes with small fire;
Step S303:Rhizoma Dioscoreae, Radix Cyathulae, Myrrha, Rhizoma Acori Calami are added in decocting container again;
Step S4:First make decocting container herb liquid seethe with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 need to be stirred when boiling medicine ~ 3 times;
Step S5:After the completion of decoction, medicinal liquid is leached, obtain medicinal liquid and be endo-medicine;
Step S6:Second decoction is carried out one hour using 0.7 ~ 0.8L clear water or pure water repeat step S3 ~ S5;
Third time is carried out using 0.5 ~ 0.6L clear water or pure water repeat step S3 ~ S5 to decoct one hour.
Embodiment 2:
Including 12 parts of Fructus Aurantii by weight, 20 parts of Lignum Santali Albi, 15 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Asparagi, 15 parts of the Rhizoma Pinelliae, 10 parts of Herba Melicae Scabrosae, wood Fragrant 6 parts, 6 parts of Flos Caryophylli, 16 parts of Rhizoma Dioscoreae, 18 parts of Radix Cyathulae, 12 parts of Myrrha, 14 parts of Rhizoma Acori Calami.
Embodiment 3:
Including 16 parts of Fructus Aurantii by weight, 20 parts of Lignum Santali Albi, 15 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Asparagi, 13 parts of the Rhizoma Pinelliae, 14 parts of Herba Melicae Scabrosae, wood Fragrant 10 parts, 9 parts of Flos Caryophylli, 16 parts of Rhizoma Dioscoreae, 15 parts of Radix Cyathulae, 16 parts of Myrrha, 10 parts of Rhizoma Acori Calami.
Embodiment 4:
Including 13 parts of Fructus Aurantii by weight, 16 parts of Lignum Santali Albi, 17 parts of the Rhizoma Atractylodis Macrocephalae, 11 parts of Radix Asparagi, 14 parts of the Rhizoma Pinelliae, 12 parts of Herba Melicae Scabrosae, wood Fragrant 11 parts, 8 parts of Flos Caryophylli, 13 parts of Rhizoma Dioscoreae, 14 parts of Radix Cyathulae, 13 parts of Myrrha, 11 parts of Rhizoma Acori Calami.
Toxicology test:
Acute toxicity test:
Experimental observation, because measuring LD50, therefore has carried out the measure of maximum dosage-feeding.Chinese medicine compound prepared by embodiment 1 Mixture is dissolved in sterile saline, is configured to solution gavage mice, is as a result shown, is given birth to medicine maximum administration concentration 9.65 Medicine/ml, maximum administered volume 50ml/kg was administered twice in 24 hours to mouse stomach, and mice maximum dosage-feeding is 763.25g There is not untoward reaction and death, each internal organs no abnormality seen of anatomic observation in crude drug/kg, animal.
Long term toxicity test:
This test applies SD rats 80, Chinese medicine compound mixture prepared by embodiment 1 to be dissolved in sterile saline, configures Into solution gavage, if matched group and 24g, 35g, 49g crude drug/kg dosage groups, continuous gavage is administered 12 weeks, in the observation present invention Impact of the drug composition to animal indices.Result of the test shows, successive administration 12 weeks, and the Chinese medicine composition of the present invention is to big Body weight, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index of Mus etc. have no significant effect;Blood biochemical 12 Item index determining result, 12 weeks low dose group BiLi values of administration are higher than matched group(P<0.05);Low dose group, middle dose group TP value Higher than matched group(P<0.05), but within normal physiologic range, other indexs compare no significant difference with matched group.Recover Phase, each administration group indices measured value compared equal no significant difference with matched group.The each internal organs gross examination of skeletal muscle no abnormality seen of each group.
The clinical statisticses data of various patients w ith peptic ulcer diseases is directed to using medicine of the present invention:
Through the Clinical practice of 50 patients, wherein male patient 27, female patient 23, medication age object 20 ~ 50 years old.Wherein most It is little 21 years old, maximum 49 years old, 28 years old mean age.
Zhang, man, people from Jiangsu, 48 years old, gastroscopy the year before be multiple gastric ulcer, clinical symptoms based on having a stomach-ache, Recently the pain increased, and emits to back, both sides of the chest and chest, and taking the medicines such as ranitidine, Losec can make remission, but be discontinued Recur immediately afterwards, patient takes the present invention and has a stomach-ache alleviations after ten days, stool is normal, is emotionally stable, spirit is preferable.Continuous medication three Recheck after the individual course for the treatment of, ulcer healing, it is certainly modern good to continue medication after treatment one month.
The above, is only presently preferred embodiments of the present invention, not does any pro forma restriction to the present invention, it is every according to According to any simple modification, equivalent variations that the technical spirit of the present invention is made to above example, the protection of the present invention is each fallen within Within the scope of.

Claims (5)

1. a kind of Chinese medicinal preparation method that can treat gastric ulcer, it is characterised in that:Including following step:
Step S1:In parts by weight, weigh 12 ~ 16 parts of Fructus Aurantii, 12 ~ 20 parts of Lignum Santali Albi, 15 ~ 19 parts of the Rhizoma Atractylodis Macrocephalae, 10 ~ 12 parts of Radix Asparagi, half 10 ~ 15 parts of summer, 10 ~ 16 parts of Herba Melicae Scabrosae, 6 ~ 12 parts of the Radix Aucklandiae, 6 ~ 10 parts of Flos Caryophylli, 12 ~ 16 parts of Rhizoma Dioscoreae, 10 ~ 18 parts of Radix Cyathulae, Myrrha 12 ~ 16 parts, 8 ~ 14 parts of Rhizoma Acori Calami;
Step S2:By above-mentioned whole raw material of Chinese medicine medicines, to be soaked 30 minutes with clear water or pure water in advance, water consumption for immersion is 0.9 ~ 1.1L;
Step S3:The liquid medicine of the raw material of Chinese medicine medicine after immersion and its immersion is added in decocting container, is added a cover and is decocted jointly;
Step S4:First make decocting container herb liquid seethe with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 need to be stirred when boiling medicine ~ 3 times;
Step S5:After the completion of decoction, medicinal liquid is leached, obtain medicinal liquid and be endo-medicine.
2. a kind of Chinese medicinal preparation method that can treat gastric ulcer according to claim 1, it is characterised in that:Described step Rapid S3 includes following step:
Step S301:First Fructus Aurantii, Lignum Santali Albi, the Rhizoma Atractylodis Macrocephalae, Radix Asparagi are added in decocting container and are decocted 10 minutes with small fire;
Step S302:The Rhizoma Pinelliae, Herba Melicae Scabrosae, the Radix Aucklandiae, Flos Caryophylli are added in decocting container are again decocted 10 minutes with small fire;
Step S303:Rhizoma Dioscoreae, Radix Cyathulae, Myrrha, Rhizoma Acori Calami are added in decocting container again.
3. a kind of Chinese medicinal preparation method that can treat gastric ulcer according to claim 1, it is characterised in that:Described step Rapid S2 ~ S5 is decoction for the first time, also including step S6:
Second decoction is carried out using 0.7 ~ 0.8L clear water or pure water repeat step S3 ~ S5;
Third time decoction is carried out using 0.5 ~ 0.6L clear water or pure water repeat step S3 ~ S5.
4. a kind of Chinese medicinal preparation method that can treat gastric ulcer according to claim 3, it is characterised in that:Described Once decocting is carried out two hours, and second decoction is carried out one hour, and third time is decocted and carries out one hour.
5. a kind of Chinese medicinal preparation method that can treat gastric ulcer according to claim 1, it is characterised in that:Described decocts Medicine container is marmite, enamel ware or rustless steel, avoids and uses ironware.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468857A (en) * 2017-08-29 2017-12-15 成都泠汐尚品科技有限公司 A kind of Chinese medicinal preparation method that can treat gastric ulcer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101199809A (en) * 2007-12-19 2008-06-18 牟秉芳 Chinese medicine prescription oral administration for treating gastric ulcer
CN104225378A (en) * 2014-09-25 2014-12-24 刘会焕 Traditional Chinese medicine composition for treating stomach ulcer and preparation method of traditional Chinese medicine composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101199809A (en) * 2007-12-19 2008-06-18 牟秉芳 Chinese medicine prescription oral administration for treating gastric ulcer
CN104225378A (en) * 2014-09-25 2014-12-24 刘会焕 Traditional Chinese medicine composition for treating stomach ulcer and preparation method of traditional Chinese medicine composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468857A (en) * 2017-08-29 2017-12-15 成都泠汐尚品科技有限公司 A kind of Chinese medicinal preparation method that can treat gastric ulcer

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