CN105327066A - Method for preparing traditional Chinese medicinal composition for treating postpartum hypogalactia - Google Patents
Method for preparing traditional Chinese medicinal composition for treating postpartum hypogalactia Download PDFInfo
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Abstract
The invention discloses a method for preparing a traditional Chinese medicinal composition for treating postpartum hypogalactia, and belongs to the technical field of medicines. The method specifically comprises the following steps: crushing the following raw materials, namely dried fruits of liquidambar formosana hance, radix bupleuri, immature bitter orange, cyperus rotundus, loofah sponge, dandelion, spina gleditsiae and mangnolia officinalis, decocting the crushed raw materials with water, filtering, merging the filtrate, concentrating, and preparing the concentrate into thick paste, so that the traditional Chinese medicinal composition provided by the invention is obtained. The traditional Chinese medicinal composition prepared by the method disclosed by the invention is strong in synergistic effect, high in safety, short in treatment course, and high in efficiency; the traditional Chinese medicinal composition can be prepared into commonly used medicinal preparations, which are easy to carry, convenient to take and facilitate industrialized application.
Description
Technical field
The invention belongs to medical art, particularly a kind of method preparing the Chinese medicine composition for the treatment of puerperal hypogalactia.
Background technology
In the postpartum breastfeeding phase, mammary gland is without galactopoiesis, or lactation amount is few, the person that can not meet feeding infant, claims puerperal hypogalactia.Puerpera generally point is just starting there is galactopoiesis in puerperium 2-3 days, but amount is few, and now milk is normal phenomenon less.After having spent 2-3 days, breast just increases gradually, and becomes hard full, pain and generating heat, and sometimes also there will be slight body temperature raises, and then milk just should be more and more.If at this moment though breast is swollen, milk is also little, or breast is not swollen, milk drop all without, then claim hypogalactia.Its reason main with physical weakness, spirit depressing, do not have enough sleep, nutrition is not good enough or suckling method is improper relevant.
The traditional Chinese medical science is referred to as " puerperal hypogalactia ", " lack of lactation after delivery " etc.Therefore the traditional Chinese medical science thinks that hypogalactia of lying-in woman is many because of caused by deficiency of qi and blood, stagnation of QI due to depression of the liver.Its pathogeny one is change source deficiency, and two is that the stasis of blood is stagnant not all right.Common typing has deficient qi and blood, irritability stasis.
Weak type of qi and blood main syndromes: puerperal, breast was few, even completely without, milk is rare clearly, soft breast, and without sensation of fullness, refreshing tired lack of appetite, lusterless complexion, light red tongue, tongue is few, thready and weak pulse.Syndrome analysis: deficient qi and blood, milk source is not enough, agalactia can under, therefore breast less or completely without; Mammary gland is hollow, therefore soft breast, without sensation of fullness; Insufficiency of vital energy and blood, yang-energy is depressed, dysfunction of the spleen in transportation, therefore refreshing tired lack of appetite; Deficiency of vital energy insufficiency of blood, can not go up honor, then lusterless complexion.Light red tongue, tongue is few, thready and weak pulse, is levying of insufficiency of vital energy and blood.Therapeutic rules: benefiting qi and nourishing blood, helps with lactogenesis.
Irritability stasis type main syndromes: puerperal, milk was puckery few, dense thick, or agalactia, the hard pain of mammary swelling, depressed emotion, breast side of body feeling of distension and oppression, inappetence, or slight fever, body of the tongue is normal, yellow and thin fur, stringy and thready pulse or stringy and rapid pulse.Syndrome analysis: feelings will is not relaxed, depression of liver-QI, functional activity of QI being not smooth, newborn arteries and veins is retarded by silt, and causes and makes that milk does not draw and milk is puckery few; Human milk silt, then hard, the pain of mammary swelling, milk is dense thick; The liver pulse cloth side of body rib, irritability stasis, loses a surname Yu and reaches, then breast side of body feeling of distension and oppression; Depression of liver-QI, then depressed emotion; Wood Yu Ke soil, dysfunction of the spleen in transportation, then inappetence; Breast becomes silted up with the passing of time heat-transformation, then slight fever.Body of the tongue is normal, yellow and thin fur, stringy and thready pulse or stringy and rapid pulse, is levying of stagnation of QI due to depression of the liver or heat-transformation.Therapeutic rules: dispersing the stagnated live-QI to relieve the stagnation of QI, active lactogenesis.
For the Therapeutic Method of puerperal hypogalactia, mainly contain dietetic therapy, acupuncture, massage, Chinese medicinal formulae, armarium auxiliary suction, milk ejection etc., being generally used is Dietotherapy method among the people, can not for cause of disease diagnosis and treatment, and curative effect is definite not.Existing lactogenic Chinese patent medicine has lactogenesis electuary, stimulating milk secretion spring loose, but these pharmaceutical formulations are complicated, and how containing rare medicinal herbs, expensive, have impact on it and apply.
Summary of the invention
The invention provides that a kind of raw material is easy to get, formula is simple, the Chinese medicine composition of rapid-action, eutherapeutic treatment puerperal hypogalactia, be made up of following eight taste Raw material processings: Fructus Liquidambaris, Radix Bupleuri, Fructus Aurantii Immaturus, Rhizoma Cyperi, Retinervus Luffae Fructus, Herba Taraxaci, Spina Gleditsiae, Cortex Magnoliae Officinalis.
Preferably, a kind of Chinese medicine composition for the treatment of puerperal hypogalactia, be made up of the Raw material processing of following weight parts:
Fructus Liquidambaris 4-12 part, Radix Bupleuri 4-12 part, Fructus Aurantii Immaturus 4-12 part, Rhizoma Cyperi 4-12 part, Retinervus Luffae Fructus 4-12 part, Herba Taraxaci 4-12 part, Spina Gleditsiae 1-4 part, Cortex Magnoliae Officinalis 2-6 part.
Preferably, the Chinese medicine composition for the treatment of puerperal hypogalactia, be made up of the Raw material processing of following weight parts:
Fructus Liquidambaris 8 parts, Radix Bupleuri 8 parts, Fructus Aurantii Immaturus 6 parts, Rhizoma Cyperi 8 parts, Retinervus Luffae Fructus 8 parts, Herba Taraxaci 6 parts, Spina Gleditsiae 2 parts, Cortex Magnoliae Officinalis 4 parts.
Preferably, the Chinese medicine composition for the treatment of puerperal hypogalactia, be made up of the Raw material processing of following weight parts:
Fructus Liquidambaris 12 parts, Radix Bupleuri 6 parts, Fructus Aurantii Immaturus 6 parts, Rhizoma Cyperi 6 parts, Retinervus Luffae Fructus 12 parts, Herba Taraxaci 8 parts, Spina Gleditsiae 2 parts, Cortex Magnoliae Officinalis 6 parts.
Present invention also offers a kind of method preparing the Chinese medicine composition for the treatment of puerperal hypogalactia, specifically comprise the steps:
After the Fructus Liquidambaris of above-mentioned weight portion, Radix Bupleuri, Fructus Aurantii Immaturus, Rhizoma Cyperi, Retinervus Luffae Fructus, Herba Taraxaci, Spina Gleditsiae, each raw material pulverizing of Cortex Magnoliae Officinalis, add soak by water 2-3 time of medical material gross weight 6-12 times amount, each 0.5-2 hour, filter cleaner extracting juice merges, and when the filtrate after merging is concentrated into 60 DEG C, relative density is the thick paste of 1.15-1.30.
Those skilled in the art directly can be used as medicine on obtained thick paste basis to take or add on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.As the oral drugs of the solid dosage form such as conventional tablet (dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent tablet), capsule (hard capsule, soft capsule), granule, pill (drop pill), powder can be made, the oral drugs of the liquid forms such as syrup, oral liquid, water preparation, mixture, decoction also can be made.Therefore, in this pharmaceutical composition except effective ingredient, pharmaceutically acceptable adjuvant can also be contained.Preferably, pharmaceutical composition of the present invention conveniently preparation technology be prepared into capsule, syrup or tablet etc.
Meridian distribution of property and flavor and the function of crude drug of the present invention cure mainly:
Fructus Liquidambaris: property is bitter is flat; Return liver, kidney channel.Can dispelling, collateral-activating, diuretic stimulates the menstrual flow, for arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Radix Bupleuri: property is bitter, is slightly cold; Return liver, gallbladder meridian; Can reconciling superficies and interior, soothing the liver, yang invigorating, for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Fructus Aurantii Immaturus: property is bitter, pungent, sour, temperature; Return spleen, stomach warp; Can dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm, stops, feeling of fullness distending pain in stagnant, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.
Rhizoma Cyperi: pungent, the micro-hardship of property, micro-sweet, flat; Return liver, spleen, tri-jiao channel; Can promoting QI circulation for relieving depression, menstruction regulating and pain relieving, for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Retinervus Luffae Fructus: property is sweet is flat; Return lung, stomach, Liver Channel; Can dredging collateral, invigorate blood circulation, dispel the wind, for arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.
Herba Taraxaci: property is bitter, sweet, cold; Return liver, stomach warp; Can heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Spina Gleditsiae: property is pungent, temperature; Can search wind, draw out pus by applying a plaster to the affected part, detumescence, evacuation of pus, controls carbuncle, sore, leprosy, tinea skin ulcer, placenta retention.1. " Bencao Tujing ": " rice vinegar is endured tender pricker and done dense decocting, with deposited skin ulcer tinea.It is up that " 2. Yang Shiying: " can draw all medicines, controls part of the body cavity above the diaphragm housing the heart and lungs disease." 3. " detailed outline ": " controls carbuncle, acute mastitis, scrofula caused by pathogenic wind malignant boil, retention of placenta, parasite killing." 4. " Traditional Chinese Medicine in Sichuan will ": " controls pityriasis rosea rash, and can lactogenesis."
Cortex Magnoliae Officinalis: property is bitter, pungent, temperature; Return spleen, stomach, lung, large intestine channel; Can dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full, and for humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
The side of Chinese medicine composition of the present invention separates:
The present invention treats Fructus Liquidambaris in the Chinese medicine composition of puerperal hypogalactia and to pass through the twelve regular channels, mainly returns Liver Channel, has depressed liver-energy dispersing and QI regulating resolving depression, and blood stasis dispelling stimulates the menstrual flow the merit of stimulating milk secretion, thus can treat amenorrhea caused by married woman's depression of liver-QI, puerperal galactostasis or distending pain of the breast etc.The pungent row hardship of Radix Bupleuri is let out, and property is apt to bar and is reached irritability, dispersing the stagnated live-QI to relieve the stagnation of QI, therefore availablely controls the liver failing to maintain the normal flow of QI, the distending pain of the breast caused by the strongly fragrant resistance of mechanism of qi, and the gas of the clear sun of Radix Bupleuri energy elevate a turnable ladder taste, availablely controls deficiency of QI in middle-JIAO.The pungent row hardship of Fructus Aurantii Immaturus is fallen, and kind dispelling the stagnated QI is except painful abdominal mass, and consumer product dredge stasis, controls eating accumulation, gastral cavity abdomen feeling of fullness distending pain, and trifoliate orange and Cortex Magnoliae Officinalis: Cortex Magnoliae Officinalis toil temperature, can dampness expectorant, and the therapeutic method to keep the adverse QI flowing downwards is except expiring.Two medicine compatibilities, can strengthen promoting QI to circulate and dispersing the agglomeration of the pathogens, and expectorant is except full effect.Rhizoma Cyperi acrid in the mouth, micro-hardship, micro-sweet and property are put down, and enter Liver Channel, and pungent energy passes through, the pent-up of kind loose irritability, bitter can catharsis, with the perverse and unreasonable manner of suppressing the hyperactive liver gas, micro-sweet emergency is the key medicine of dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, for stagnation of QI due to depression of the liver, menoxenia, dysmenorrhea, distending pain of the breast etc.Retinervus Luffae Fructus energy the meridian dredging, and blood vessels, be good at dispelling wind and removing obstruction in the collateral, and can control married woman's stagnation of QI-blood in puerperal, galactostasis, acute mastitis swells and ache.The drop-down of Herba Taraxaci bitter in the mouth energy, the heat clearing away of cold energy, loose stagnant gas of holding concurrently is the good merchantable brand of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, is apt to control all cards of inside and outside pyretic toxicity carbuncle sore, double stimulating milk secretion of stimulating the menstrual flow, again for treating acute mastitis good medicine.Spina Gleditsiae removes air slaking expectorant, and relieve internal heat counteracting toxic substances, " Traditional Chinese Medicine in Sichuan will ": control pityriasis rosea rash, and can lactogenesis.Cortex Magnoliae Officinalis acrid in the mouth and main row fall apart, and dredge promoting the circulation of QI machine, circulation of qi promoting de-swelling, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, can control seven emotions pent-up.Full side shares can dispersing the stagnated live-QI to relieve the stagnation of QI, and active lactogenesis, is used for the treatment of emotional stress, stagnation of QI impairing the liver, and the newborn arteries and veins caused by stagnation of QI due to depression of the liver is obstructed, the diseases such as galactozemia.
The present invention also asks protection aforementioned pharmaceutical compositions at preparation treatment puerperal hypogalactia, the purposes particularly in preparation treatment irritability stasis type puerperal hypogalactia medicine.
The present invention has cheap compared with existing medicine.Raw material is easy to get, and synergism is strong, and dosage is few, and safety is high, short treating period, effective percentage advantages of higher, and the present invention can be prepared into conventional pharmaceutical preparation, is easy to carry, and taking convenience, is easy to commercial application.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
embodiment 1
The each raw material of the present invention is taken: Fructus Liquidambaris 8 parts, Radix Bupleuri 8 parts, Fructus Aurantii Immaturus 6 parts, Rhizoma Cyperi 8 parts, Retinervus Luffae Fructus 8 parts, Herba Taraxaci 6 parts, Spina Gleditsiae 2 parts, Cortex Magnoliae Officinalis 4 parts by following weight portion.
embodiment 2
The each raw material of the present invention is taken: Fructus Liquidambaris 9 parts, Radix Bupleuri 12 parts, Fructus Aurantii Immaturus 12 parts, Rhizoma Cyperi 12 parts, Retinervus Luffae Fructus 12 parts, Herba Taraxaci 12 parts, Spina Gleditsiae 4 parts, Cortex Magnoliae Officinalis 6 parts by following weight portion.
embodiment 3
The each raw material of the present invention is taken: Fructus Liquidambaris 4 parts, Radix Bupleuri 8 parts, Fructus Aurantii Immaturus 4 parts, Rhizoma Cyperi 4 parts, Retinervus Luffae Fructus 12 parts, Herba Taraxaci 6 parts, Spina Gleditsiae 4 parts, Cortex Magnoliae Officinalis 4 parts by following weight portion.
embodiment 4
The each raw material of the present invention is taken: Fructus Liquidambaris 8 parts, Radix Bupleuri 4 parts, Fructus Aurantii Immaturus 4 parts, Rhizoma Cyperi 4 parts, Retinervus Luffae Fructus 8 parts, Herba Taraxaci 12 parts, Spina Gleditsiae 2 parts, Cortex Magnoliae Officinalis 6 parts by following weight portion.
embodiment 5
The each raw material of the present invention is taken: Fructus Liquidambaris 12 parts, Radix Bupleuri 6 parts, Fructus Aurantii Immaturus 6 parts, Rhizoma Cyperi 6 parts, Retinervus Luffae Fructus 12 parts, Herba Taraxaci 8 parts, Spina Gleditsiae 2 parts, Cortex Magnoliae Officinalis 6 parts by following weight portion.
The preparation method of embodiment 1-5 is as follows: after taking Fructus Liquidambaris, Radix Bupleuri, Fructus Aurantii Immaturus, Rhizoma Cyperi, Retinervus Luffae Fructus, Herba Taraxaci, Spina Gleditsiae, Cortex Magnoliae Officinalis pulverizing according to above-mentioned weight portion respectively, add the soak by water 2 times of medical material gross weight 10 times amount, each 1 hour, filter cleaner extracting juice merges, and when the filtrate after merging is concentrated into 60 DEG C, relative density is the thick paste of 1.15-1.30.Those skilled in the art directly can be used as medicine and be taken or add acceptable adjuvant on pharmaceutics and be prepared into the conventional oral formulations such as capsule, syrup or tablet on obtained thick paste basis.
When using medicine composite for curing puerperal hypogalactia of the present invention, when taking prepared oral formulations, every day 2 times, amounting to crude drug each serving dosage is 2.0-3.0g.
clinical data:
1, case selection:
Select hospital for obstetrics ward and outpatient clinic meet irritability stasis type puerperal hypogalactia (irritability stasis: puerperal milk very less or completely without, milk is thick, and the hard and pain of mammary swelling.Depressed emotion is discomfort, distending pain in the chest and hypochondrium, loss of appetite, or has slight fever.Dimly red tongue or sharp limit red, yellow and thin fur, stringy and thready pulse or stringy and rapid pulse.) diagnostic criteria patient 270 example.Patient age 22-36 year, 28.2 years old mean age, the shortest person of the course of disease 5 days, most elder 35 days, average 14 days.Patient is divided into three groups at random: treatment group 1, treatment group 2 and matched group, often organizes each 90 routine patients.The course of disease, the degrees of symptoms of three groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group 1 takes the capsule prepared by the embodiment of the present invention 1 prescription and preparation method, oral, every day 2 times, and each 1 time sooner or later, each 4 (containing crude drug 2g), warm water delivery service after meal, serve on 3-7 days.
Treatment group 2 takes the capsule prepared by the embodiment of the present invention 5 prescription and preparation method, oral, every day 2 times, and each 1 time sooner or later, each 4 (containing crude drug 2g), warm water delivery service after meal, serve on 3-7 days.
Matched group gives stimulating milk secretion spring loose (each 30 grams of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Trichosanthis, Radix Paeoniae Alba, Radix Rehmanniae, Radix Bupleuri, Pericarpium Citri Reticulatae Viride, Radix Rhapontici, Radix Platycodonis, Caulis Akebiae, the Radix Angelicae Dahuricae, each 15 grams of Medulla Tetrapanacis, Squama Manis 45 grams, Semen Vaccariae 90 grams, 7.5 grams, Radix Glycyrrhizae) treatment.Serve on 3-7 days.
3, efficacy determination:
Cure: galactopoiesis is normal, can normal suckling.
Take a turn for the better: galactopoiesis increases, or galactopoiesis is normal, but the few inadequate feeding infant of amount.
Do not heal: galactopoiesis is without change.
4, therapeutic outcome:
See table 1
Table 1 result of the test
Note:
*represent compared with matched group, P < 0.05.
After treatment of control group, total effective rate is 92.2%, average total effective rate after treatment group treatment is 99.45%, and the medicine prepared by embodiment 1 prescription is all effective to all patients for the treatment of group 1, after three groups of cases treatments, total effective rate comparing differences have statistical significance difference to have statistical significance (P < 0.05).Illustrate that treatment group curative effect is better than matched group.Namely illustrate that the Chinese medicine composition prepared by preparation method of the present invention equally can reach the loose therapeutic effect of stimulating milk secretion spring after not using the rare Chinese medicines such as Squama Manis, be even obviously better than the therapeutic effect that stimulating milk secretion spring is loose.
In safety evaluatio, the routine blood test before and after treatment group patient consumes, routine urinalysis, liver function, renal function, electrocardiogram etc. inspections do not find obvious exception.
Illustrate that using traditional Chinese medicine composition for treating puerperal hypogalactia of the present invention particularly to treat belongs to irritability stasis type puerperal hypogalactia determined curative effect, treating both the principal and secondary aspects of a disease thus, safe and reliable, the effective ways that can be used as treatment irritability stasis type puerperal hypogalactia are promoted the use of in clinical.
Claims (3)
1. prepare the method for the Chinese medicine composition for the treatment of puerperal hypogalactia for one kind, it is characterized in that, comprise the following steps: after raw material Fructus Liquidambaris 4-12 part of following weight parts, Radix Bupleuri 4-12 part, Fructus Aurantii Immaturus 4-12 part, Rhizoma Cyperi 4-12 part, Retinervus Luffae Fructus 4-12 part, Herba Taraxaci 4-12 part, Spina Gleditsiae 1-4 part, Cortex Magnoliae Officinalis 2-6 part are pulverized, add soak by water 2-3 time of medical material gross weight 6-12 times amount, each 0.5-2 hour, filter cleaner extracting juice merges, and when the filtrate after merging is concentrated into 60 DEG C, relative density is the thick paste of 1.15-1.30, obtains described Chinese medicine composition.
2. the method for the Chinese medicine composition of preparation treatment puerperal hypogalactia as claimed in claim 1, is characterized in that: the weight portion of described raw material is Fructus Liquidambaris 8 parts, Radix Bupleuri 8 parts, Fructus Aurantii Immaturus 6 parts, Rhizoma Cyperi 8 parts, Retinervus Luffae Fructus 8 parts, Herba Taraxaci 6 parts, Spina Gleditsiae 2 parts, Cortex Magnoliae Officinalis 4 parts.
3. the method for the Chinese medicine composition of preparation treatment puerperal hypogalactia as claimed in claim 1, is characterized in that: the weight portion of described raw material is Fructus Liquidambaris 12 parts, Radix Bupleuri 6 parts, Fructus Aurantii Immaturus 6 parts, Rhizoma Cyperi 6 parts, Retinervus Luffae Fructus 12 parts, Herba Taraxaci 8 parts, Spina Gleditsiae 2 parts, Cortex Magnoliae Officinalis 6 parts.
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| CN105770731A (en) * | 2016-03-09 | 2016-07-20 | 张洪美 | Traditional Chinese medicine composition for treating phlegm-damp stasis type postnatal lactation lack |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105770731A (en) * | 2016-03-09 | 2016-07-20 | 张洪美 | Traditional Chinese medicine composition for treating phlegm-damp stasis type postnatal lactation lack |
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Application publication date: 20160217 |